Thomas Jefferson University

David G Edwards

TitleAssoc Prof CHP
InstitutionThomas Jefferson University
DepartmentNursing - Undergraduate
Address25 North College Ave.
Newark DE 19716
Phone302-831-3363
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    R21DK077306     (EDWARDS, DAVID G)Aug 1, 2007 - Jul 31, 2010
    NIH
    Oxidative Stress and Vascular Function in Chronic Kidney Disease
    Role: Principal Investigator
    R15DK080469     (EDWARDS, DAVID G)Aug 1, 2008 - Jul 31, 2010
    NIH
    Microvascular Function in Chronic Kidney Disease
    Role: Principal Investigator
    R01HL104106     (FARQUHAR, WILLIAM B)Sep 7, 2011 - Jun 30, 2022
    NIH
    VASCULAR EFFECTS OF DIETARY SALT IN HUMANS WITH SALT-RESISTANT BP
    Role: Co-Principal Investigator
    R01HL113514     (EDWARDS, DAVID G)Jul 15, 2013 - Jun 30, 2017
    NIH
    Exercise and Vascular Function in Chronic Kidney Disease
    Role: Principal Investigator
    P20GM113125     (EDWARDS, DAVID G)May 15, 2016 - May 31, 2026
    NIH
    Center of Biomedical Research Excellence in Cardiovascular Health
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Romberger NT, Stock JM, Patik JC, McMillan RK, Lennon SL, Edwards DG, Farquhar WB. Inverse salt sensitivity in normotensive adults: role of demographic factors. J Hypertens. 2023 Mar 10. PMID: 36928305.
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    2. Kirkman DL, Ramick MG, Muth BJ, Stock JM, Townsend RR, Edwards DG. Sex differences in microvascular function and arterial hemodynamics in nondialysis chronic kidney disease. Am J Physiol Heart Circ Physiol. 2022 12 01; 323(6):H1130-H1136. PMID: 36269643.
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    3. Shenouda N, Patik JC, Edwards DG. Reflecting on the Blood Pressure Lowering Effects of Inorganic Nitrate Supplementation in Patients with Type 2 Diabetes. Am J Hypertens. 2022 Jun 21. PMID: 35728074.
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    4. Nathaniel S, McGinty S, Witman MAH, Edwards DG, Farquhar WB, Hosmane V, Wenner MM. Impact of angiotensin receptor-neprilysin inhibition on vascular function in heart failure with reduced ejection fraction: A pilot study. Physiol Rep. 2022 Mar; 10(5):e15209. PMID: 35246960.
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    5. Nathaniel S, McGinty S, Witman MA, Edwards DG, Farquhar WB, Hosmane V, Wenner MM. A new lead: Sacubitril-valsartan's unique benefit in HFrEF could lie with sympathoinhibition. Auton Neurosci. 2022 Mar; 238:102949. PMID: 35131171.
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    6. Stock JM, Chelimsky G, Edwards DG, Farquhar WB. Dietary sodium and health: How much is too much for those with orthostatic disorders? Auton Neurosci. 2022 Jan 20; 238:102947. PMID: 35131651.
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    7. Shoemaker LN, Haigh KM, Kuczmarski AV, McGinty SJ, Welti LM, Hobson JC, Edwards DG, Feinberg RF, Wenner MM. ETB receptor-mediated vasodilation is regulated by estradiol in young women. Am J Physiol Heart Circ Physiol. 2021 09 01; 321(3):H592-H598. PMID: 34415188.
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    8. Stock JM, Chirinos JA, Edwards DG. Lower-body dynamic exercise reduces wave reflection in healthy young adults. Exp Physiol. 2021 Aug; 106(8):1720-1730. PMID: 33999464.
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    9. Patik JC, Stock JM, Shenouda N, Chouramanis NV, Mehrer JD, Chirinos JA, Edwards DG. Pulsatile load and wasted pressure effort are reduced following an acute bout of aerobic exercise. J Appl Physiol (1985). 2021 07 01; 131(1):184-191. PMID: 33982596.
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    10. Kirkman DL, Robinson AT, Rossman MJ, Seals DR, Edwards DG. Mitochondrial contributions to vascular endothelial dysfunction, arterial stiffness, and cardiovascular diseases. Am J Physiol Heart Circ Physiol. 2021 05 01; 320(5):H2080-H2100. PMID: 33834868.
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    11. Shenouda N, Stock JM, Patik JC, Chirinos JA, Edwards DG. Personalized physiologic flow waveforms improve wave reflection estimates compared to triangular flow waveforms in adults. Am J Physiol Heart Circ Physiol. 2021 05 01; 320(5):H1802-H1812. PMID: 33710924.
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    12. Hoopes EK, D'Agata MN, Berube FR, Ranadive SM, Patterson F, Farquhar WB, Edwards DG, Witman MA. Consistency where it counts: Sleep regularity is associated with circulating white blood cell count in young adults. Brain Behav Immun Health. 2021 May; 13:100233. PMID: 34589748.
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    13. Patik JC, Lennon SL, Farquhar WB, Edwards DG. Mechanisms of Dietary Sodium-Induced Impairments in Endothelial Function and Potential Countermeasures. Nutrients. 2021 Jan 19; 13(1). PMID: 33477837.
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    14. Kirkman DL, Ramick MG, Muth BJ, Stock JM, Townsend RR, Edwards DG. A randomized trial of aerobic exercise in chronic kidney disease: evidence for blunted cardiopulmonary adaptations. Ann Phys Rehabil Med. 2020 Dec 11; 101469. PMID: 33316435.
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    15. Ramick MG, Kirkman DL, Stock JM, Muth BJ, Farquhar WB, Chirinos JA, Doulias PT, Ischiropoulos H, Edwards DG. The effect of dietary nitrate on exercise capacity in chronic kidney disease: a randomized controlled pilot study. Nitric Oxide. 2021 Jan 01; 106:17-23. PMID: 33080411.
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    16. Hoopes EK, Berube FR, D'Agata MN, Patterson F, Farquhar WB, Edwards DG, Witman MAH. Sleep Duration Regularity, But Not Sleep Duration, is Associated with Microvascular Function in College Students. Sleep. 2020 Sep 09. PMID: 32905591.
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    17. Stock JM, Chouramanis NV, Chirinos JA, Edwards DG. Dynamic and Isometric Handgrip Exercise Increase Wave Reflection in Healthy Young Adults. J Appl Physiol (1985). 2020 Aug 27. PMID: 32853105.
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    18. Kuczmarski AV, Shoemaker LN, Hobson JC, Edwards DG, Wenner MM. Altered endothelial ETB receptor expression in postmenopausal women. Am J Physiol Heart Circ Physiol. 2020 Jul 01; 319(1):H242-H247. PMID: 32559137.
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    19. Babcock MC, Robinson AT, Migdal KU, Watso JC, Martens CR, Edwards DG, Pescatello LS, Farquhar WB. High Salt Intake Augments Blood Pressure Responses During Submaximal Aerobic Exercise. J Am Heart Assoc. 2020 May 18; 9(10):e015633. PMID: 32406312.
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    20. Shenouda N, Ramick MG, Lennon SL, Farquhar WB, Edwards DG. High dietary sodium augments vascular tone and attenuates low-flow mediated constriction in salt-resistant adults. Eur J Appl Physiol. 2020 Apr 18. PMID: 32306153.
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    21. Babcock MC, Robinson AT, Watso JC, Migdal KU, Martens CR, Edwards DG, Pescatello LS, Farquhar WB. Salt Loading Blunts Central and Peripheral Postexercise Hypotension. Med Sci Sports Exerc. 2019 Oct 09. PMID: 31609296.
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    22. Guers JJ, Farquhar WB, Edwards DG, Lennon SL. Voluntary Wheel Running Attenuates Salt-Induced Vascular Stiffness Independent of Blood Pressure. Am J Hypertens. 2019 Aug 11. PMID: 31401651.
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    23. Ramick MG, Brian MS, Matthews EL, Patik JC, Seals DR, Lennon SL, Farquhar WB, Edwards DG. Apocynin and Tempol Ameliorate Dietary Sodium-Induced Declines in Cutaneous Microvascular Function in Salt Resistant Humans. Am J Physiol Heart Circ Physiol. 2019 May 10. PMID: 31074652.
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    24. Robinson AT, Edwards DG, Farquhar WB. The Influence of Dietary Salt Beyond Blood Pressure. Curr Hypertens Rep. 2019 Apr 25; 21(6):42. PMID: 31025198.
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    25. Katulka EK, Hirt AE, Kirkman DL, Edwards DG, Witman MAH. Altered vascular function in chronic kidney disease: evidence from passive leg movement. Physiol Rep. 2019 Apr; 7(8):e14075. PMID: 31016878.
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    26. Guers JJ, Kasecky-Lardner L, Farquhar WB, Edwards DG, Lennon SL. VOLUNTARY WHEEL RUNNING PREVENTS SALT-INDUCED ENDOTHELIAL DYSFUNCTION: ROLE OF OXIDATIVE STRESS. J Appl Physiol (1985). 2018 Dec 20. PMID: 30571282.
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    27. Sebzda KN, Kuczmarski AV, Pohlig RT, Lennon SL, Edwards DG, Wenner MM. Ovarian hormones modulate endothelin-1 receptor responses in young women. Microcirculation. 2018 Oct; 25(7):e12490. PMID: 29999581.
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    28. Babcock MC, Brian MS, Watso JC, Edwards DG, Stocker SD, Wenner MM, Farquhar WB. Alterations in dietary sodium intake affects cardiovagal baroreflex sensitivity. Am J Physiol Regul Integr Comp Physiol. 2018 Jun 27. PMID: 29949407.
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    29. Kirkman DL, Muth BJ, Stock JM, Townsend RR, Edwards DG. Cardiopulmonary exercise testing reveals subclinical abnormalities in chronic kidney disease. Eur J Prev Cardiol. 2018 Jan 01; 2047487318777777. PMID: 29808762.
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    30. Kirkman DL, Muth BJ, Ramick MG, Townsend RR, Edwards DG. Role of mitochondria-derived reactive oxygen species in microvascular dysfunction in chronic kidney disease. Am J Physiol Renal Physiol. 2018 Mar 01; 314(3):F423-F429. PMID: 29117995.
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    31. Patterson F, Grandner MA, Malone SK, Rizzo A, Davey A, Edwards DG. Sleep as a Target for Optimized Response to Smoking Cessation Treatment. Nicotine Tob Res. 2017 Oct 23. PMID: 29069464.
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    32. Matthews EL, Brian MS, Edwards DG, Stocker SD, Wenner MM, Farquhar WB. Blood pressure responses to dietary sodium: Association with autonomic cardiovascular function in normotensive adults. Auton Neurosci. 2017 12; 208:51-56. PMID: 28802637.
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    33. Muth BJ, Brian MS, Chirinos JA, Lennon SL, Farquhar WB, Edwards DG. Central systolic blood pressure and aortic stiffness response to dietary sodium in young and middle-aged adults. J Am Soc Hypertens. 2017 Oct; 11(10):627-634. PMID: 28830669.
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    34. Wenner MM, Sebzda KN, Kuczmarski AV, Pohlig RT, Edwards DG. ETB receptor contribution to vascular dysfunction in postmenopausal women. Am J Physiol Regul Integr Comp Physiol. 2017 Jul 01; 313(1):R51-R57. PMID: 28438762.
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    35. Guers JJ, Prisby RD, Edwards DG, Lennon-Edwards SL. INTERMITTENT PARATHYROID HORMONE ADMINISTRATION ATTENUATES ENDOTHELIAL DYSFUNCTION IN OLD RATS. J Appl Physiol (1985). 2016 Nov 4; jap.00348.2016. PMID: 27815368.
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    36. Matthews EL, Brian MS, Coyle DE, Edwards DG, Stocker SD, Wenner MM, Farquhar WB. Peripheral venous distension elicits a blood pressure raising reflex in young and middle-aged adults. Am J Physiol Regul Integr Comp Physiol. 2016 Jun 1; 310(11):R1128-33. PMID: 27053648.
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    37. Martens CR, Kirkman DL, Edwards DG. The Vascular Endothelium in Chronic Kidney Disease: A Novel Target for Aerobic Exercise. Exerc Sport Sci Rev. 2016 Jan; 44(1):12-9. PMID: 26509484.
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    38. Matthews EL, Brian MS, Ramick MG, Lennon-Edwards S, Edwards DG, Farquhar WB. High dietary sodium reduces brachial artery flow-mediated dilation in humans with salt-sensitive and salt-resistant blood pressure. J Appl Physiol (1985). 2015 Jun 15; 118(12):1510-5. PMID: 26078434.
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    39. Farquhar WB, Edwards DG, Jurkovitz CT, Weintraub WS. Dietary sodium and health: more than just blood pressure. J Am Coll Cardiol. 2015 Mar 17; 65(10):1042-50. PMID: 25766952.
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    40. Edwards DG, Farquhar WB. Vascular effects of dietary salt. Curr Opin Nephrol Hypertens. 2015 Jan; 24(1):8-13. PMID: 25415615.
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    41. Kirkman DL, Lennon-Edwards S, Edwards DG. The importance of exercise for chronic kidney disease patients. J Ren Nutr. 2014 Nov; 24(6):e51-3. PMID: 25443547.
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    42. Kuczmarski JM, Martens CR, Kim J, Lennon-Edwards SL, Edwards DG. Cardiac function is preserved following 4 weeks of voluntary wheel running in a rodent model of chronic kidney disease. J Appl Physiol (1985). 2014 Sep 1; 117(5):482-91. PMID: 25059238.
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    43. Martens CR, Kuczmarski JM, Kim J, Guers JJ, Brennan Harris M, Lennon-Edwards S, Edwards DG. Voluntary wheel running augments aortic l-arginine transport and endothelial function in rats with chronic kidney disease. Am J Physiol Renal Physiol. 2014 Aug 15; 307(4):F418-26. PMID: 24966085.
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    44. Lennon-Edwards S, Allman BR, Schellhardt TA, Ferreira CR, Farquhar WB, Edwards DG. Lower potassium intake is associated with increased wave reflection in young healthy adults. Nutr J. 2014; 13:39. PMID: 24775098.
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    45. DuPont JJ, Ramick MG, Farquhar WB, Townsend RR, Edwards DG. NADPH oxidase-derived reactive oxygen species contribute to impaired cutaneous microvascular function in chronic kidney disease. Am J Physiol Renal Physiol. 2014 Jun 15; 306(12):F1499-506. PMID: 24761000.
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    46. Martens CR, Kuczmarski JM, Lennon-Edwards S, Edwards DG. Impaired L-arginine uptake but not arginase contributes to endothelial dysfunction in rats with chronic kidney disease. J Cardiovasc Pharmacol. 2014 Jan; 63(1):40-8. PMID: 24084210.
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    47. Kirkman DL, Edwards DG, Lennon-Edwards S. Exercise as an Adjunct Therapy In Chronic Kidney Disease. Renal Nutr Forum. 2014; 33(4):1-8. PMID: 26069463.
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    48. Greaney JL, Matthews EL, Boggs ME, Edwards DG, Duncan RL, Farquhar WB. Exaggerated exercise pressor reflex in adults with moderately elevated systolic blood pressure: role of purinergic receptors. Am J Physiol Heart Circ Physiol. 2014 Jan; 306(1):H132-41. PMID: 24163081.
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    49. Kuczmarski JM, Martens CR, Lennon-Edwards SL, Edwards DG. Cardiac function and tolerance to ischemia-reperfusion injury in chronic kidney disease. Nephrol Dial Transplant. 2014 Aug; 29(8):1514-24. PMID: 24151020.
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    50. Greaney JL, Schwartz CE, Edwards DG, Fadel PJ, Farquhar WB. The neural interaction between the arterial baroreflex and muscle metaboreflex is preserved in older men. Exp Physiol. 2013 Oct; 98(10):1422-31. PMID: 23733520.
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    51. DuPont JJ, Greaney JL, Wenner MM, Lennon-Edwards SL, Sanders PW, Farquhar WB, Edwards DG. High dietary sodium intake impairs endothelium-dependent dilation in healthy salt-resistant humans. J Hypertens. 2013 Mar; 31(3):530-6. PMID: 23263240.
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    52. Greaney JL, Dupont JJ, Lennon-Edwards SL, Sanders PW, Edwards DG, Farquhar WB. Dietary sodium loading impairs microvascular function independent of blood pressure in humans: role of oxidative stress. J Physiol. 2012 Nov 1; 590(Pt 21):5519-28. PMID: 22907057.
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    53. Edwards DG. Exercise and diseased kidneys: are they compatible? J Physiol. 2011 Dec 15; 589(Pt 24):5897. PMID: 22174132.
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    54. Dupont JJ, Farquhar WB, Townsend RR, Edwards DG. Ascorbic acid or L-arginine improves cutaneous microvascular function in chronic kidney disease. J Appl Physiol. 2011 Dec; 111(6):1561-7. PMID: 21885796.
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    55. Wenner MM, Edwards DG, Ray CA, Rose WC, Gardner TJ, Stillabower M, Farquhar WB. Celecoxib does not alter cardiovascular and renal function during dietary salt loading. Clin Exp Pharmacol Physiol. 2011 Aug; 38(8):543-9. PMID: 21631568.
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    56. Kuczmarski JM, Darocki MD, DuPont JJ, Sikes RA, Cooper CR, Farquhar WB, Edwards DG. Effect of moderate-to-severe chronic kidney disease on flow-mediated dilation and progenitor cells. Exp Biol Med (Maywood). 2011 Sep 1; 236(9):1085-92. PMID: 21791552.
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    57. Martens CR, Edwards DG. Peripheral vascular dysfunction in chronic kidney disease. Cardiol Res Pract. 2011; 2011:267257. PMID: 21637718.
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    58. DuPont JJ, Farquhar WB, Edwards DG. Intradermal microdialysis of hypertonic saline attenuates cutaneous vasodilatation in response to local heating. Exp Physiol. 2011 Jul; 96(7):674-80. PMID: 21571814.
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    59. Delaney EP, Greaney JL, Edwards DG, Rose WC, Fadel PJ, Farquhar WB. Exaggerated sympathetic and pressor responses to handgrip exercise in older hypertensive humans: role of the muscle metaboreflex. Am J Physiol Heart Circ Physiol. 2010 Nov; 299(5):H1318-27. PMID: 20802135.
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    60. Greaney JL, Ray CA, Prettyman AV, Edwards DG, Farquhar WB. Influence of increased plasma osmolality on sympathetic outflow during apnea. Am J Physiol Regul Integr Comp Physiol. 2010 Oct; 299(4):R1091-6. PMID: 20660106.
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    61. Edwards DG, Roy MS, Prasad RY. Wave reflection augments central systolic and pulse pressures during facial cooling. Am J Physiol Heart Circ Physiol. 2008 Jun; 294(6):H2535-9. PMID: 18408124.
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    62. Young CN, Prasad RY, Fullenkamp AM, Stillbower ME, Farquhar WB, Edwards DG. Ultrasound assessment of popliteal vein compliance during a short deflation protocol. J Appl Physiol. 2008 May; 104(5):1374-80. PMID: 18309095.
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    63. Edwards DG, Mastin CR, Kenefick RW. Wave reflection and central aortic pressure are increased in response to static and dynamic muscle contraction at comparable workloads. J Appl Physiol. 2008 Feb; 104(2):439-45. PMID: 18079263.
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    64. Heffernan KS, Edwards DG, Rossow L, Jae SY, Fernhall B. External mechanical compression reduces regional arterial stiffness. Eur J Appl Physiol. 2007 Dec; 101(6):735-41. PMID: 17849144.
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    65. Heffernan KS, Jae SY, Edwards DG, Kelly EE, Fernhall B. Arterial stiffness following repeated Valsalva maneuvers and resistance exercise in young men. Appl Physiol Nutr Metab. 2007 Apr; 32(2):257-64. PMID: 17486167.
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    66. Pierce GL, Magyari PM, Aranda JM, Edwards DG, Hamlin SA, Hill JA, Braith RW. Effect of heart transplantation on skeletal muscle metabolic enzyme reserve and fiber type in end-stage heart failure patients. Clin Transplant. 2007 Jan-Feb; 21(1):94-100. PMID: 17302597.
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    67. Gosztyla AE, Edwards DG, Quinn TJ, Kenefick RW. The impact of different pacing strategies on five-kilometer running time trial performance. J Strength Cond Res. 2006 Nov; 20(4):882-6. PMID: 17149992.
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    68. Edwards DG, Gauthier AL, Hayman MA, Lang JT, Kenefick RW. Acute effects of cold exposure on central aortic wave reflection. J Appl Physiol. 2006 Apr; 100(4):1210-4. PMID: 16223975.
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    69. Edwards DG, Lang JT. Augmentation index and systolic load are lower in competitive endurance athletes. Am J Hypertens. 2005 May; 18(5 Pt 1):679-83. PMID: 15882551.
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    70. Edwards DG, Schofield RS, Magyari PM, Nichols WW, Braith RW. Effect of exercise training on central aortic pressure wave reflection in coronary artery disease. Am J Hypertens. 2004 Jun; 17(6):540-3. PMID: 15177529.
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    71. Schofield RS, Schuler BT, Edwards DG, Aranda JM, Hill JA, Nichols WW. Amplitude and timing of central aortic pressure wave reflections in heart transplant recipients. Am J Hypertens. 2002 Sep; 15(9):809-15. PMID: 12219877.
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