Shey-Shing Sheu

TitleProfessor
InstitutionThomas Jefferson University
DepartmentCenter for Translational Medic
Address1025 Walnut St.
Philadelphia PA 19107
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Federico M, la Fuente S, Palomeque J, Sheu SS. The role of mitochondria in metabolic disease: a special emphasis on the heart dysfunction. J Physiol. 2021 May 01. PMID: 33932959.
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    2. Wang W, Sheu SS. Unsolved mysteries and controversies of mitochondria in the heart - A virtual special issue in JMCC: Part IV. J Mol Cell Cardiol. 2020 Nov 20; 151:72-73. PMID: 33221273.
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    3. Hurst S, Gonnot F, Dia M, Crola Da Silva C, Gomez L, Sheu SS. Phosphorylation of cyclophilin D at serine 191 regulates mitochondrial permeability transition pore opening and cell death after ischemia-reperfusion. Cell Death Dis. 2020 Aug 19; 11(8):661. PMID: 32814770.
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    4. Wang W, Sheu SS. Unsolved mysteries and controversies of mitochondria in the heart- A Virtual Special Issue in JMCC: Part III. J Mol Cell Cardiol. 2020 Jun 27. PMID: 32603737.
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    5. Wang W, Sheu SS. Unsolved mysteries and controversies of mitochondria in the heart - A virtual special issue in JMCC: Part II. J Mol Cell Cardiol. 2020 Jun; 143:162. PMID: 32473158.
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    6. Wang W, Sheu SS. Unsolved mysteries and controversies of mitochondria in the heart - A virtual special issue in JMCC. J Mol Cell Cardiol. 2020 Apr 18. PMID: 32311414.
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    7. Lee H, Smith SB, Sheu SS, Yoon Y. The short variant of optic atrophy 1 (OPA1) improves cell survival under oxidative stress. J Biol Chem. 2020 Apr 03. PMID: 32245890.
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    8. Hu Q, Zhang H, Gutierrez Cortes N, Wu D, Wang P, Zhang J, Mattison JA, Smith E, Bettcher LF, Wang M, Lakatta EG, Sheu SS, Wang W. Increased Drp1 Acetylation by Lipid Overload Induces Cardiomyocyte Death and Heart Dysfunction. Circ Res. 2020 Jan 03. PMID: 31896304.
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    9. Tian R, Colucci WS, Arany Z, Bachschmid MM, Ballinger SW, Boudina S, Bruce JE, Busija DW, Dikalov S, Dorn GW, Galis ZS, Gottlieb RA, Kelly DP, Kitsis RN, Kohr MJ, Levy D, Lewandowski ED, McClung JM, Mochly-Rosen D, O'Brien KD, O'Rourke B, Park JY, Ping P, Sack MN, Sheu SS, Shi Y, Shiva S, Wallace DC, Weiss RG, Vernon HJ, Wong R, Schwartz Longacre L. Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure—A Report from the 2018 National Heart, Lung, and Blood Institute Workshop Circulation. 2019 Oct 01; 140(14):1205-1216. PMID: 31769940.
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    10. Dirksen RT, Wang W, Sheu SS. Introduction. Arch Biochem Biophys. 2019 Jul 15; 669:31. PMID: 31112707.
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    11. Hurst S, Baggett A, Csordas G, Sheu SS. SPG7 targets the m-AAA protease complex to process MCU for uniporter assembly, Ca2+ influx, and regulation of mitochondrial permeability transition pore opening. J Biol Chem. 2019 Jul 12; 294(28):10807-10818. PMID: 31097542.
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    12. Fernandez-Sanz C, De la Fuente S, Sheu SS. Mitochondrial Ca2+ concentrations in live cells: quantification methods and discrepancies. FEBS Lett. 2019 May 06. PMID: 31058316.
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    13. De la Fuente S, Sheu SS. SR-mitochondria communication in adult cardiomyocytes: A close relationship where the Ca2+ has a lot to say. Arch Biochem Biophys. 2019 Mar 15; 663:259-268. PMID: 30685253.
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    14. Miller BA, Wang J, Song J, Zhang XQ, Hirschler-Laszkiewicz I, Shanmughapriya S, Tomar D, Rajan S, Feldman AM, Madesh M, Sheu SS, Cheung JY. Trpm2 enhances physiological bioenergetics and protects against pathological oxidative cardiac injury: Role of Pyk2 phosphorylation. J Cell Physiol. 2019 Jan 13. PMID: 30637731.
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    15. De La Fuente S, Lambert JP, Nichtova Z, Fernandez Sanz C, Elrod JW, Sheu SS, Csordás G. Spatial Separation of Mitochondrial Calcium Uptake and Extrusion for Energy-Efficient Mitochondrial Calcium Signaling in the Heart. Cell Rep. 2018 Sep 18; 24(12):3099-3107.e4. PMID: 30231993.
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    16. Wang P, Fernandez-Sanz C, Wang W, Sheu SS. Why don't mice lacking the mitochondrial Ca2+ uniporter experience an energy crisis? J Physiol. 2018 Sep 15. PMID: 30218574.
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    17. Eyenga P, Roussel D, Morel J, Rey B, Romestaing C, Gueguen-Chaignon V, Sheu SS, Viale JP. Time course of liver mitochondrial function and intrinsic changes in oxidative phosphorylation in a rat model of sepsis. Intensive Care Med Exp. 2018 Sep 05; 6(1):31. PMID: 30187255.
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    18. Jhun BS, O-Uchi J, Adaniya SM, Mancini TJ, Cao JL, King ME, Landi AK, Ma H, Shin M, Yang D, Xu X, Yoon Y, Choudhary G, Clements RT, Mende U, Sheu SS. Protein kinase D activation induces mitochondrial fragmentation and dysfunction in cardiomyocytes. J Physiol. 2018 Mar 01; 596(5):827-855. PMID: 29313986.
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    19. Wang W, Fernandez-Sanz C, Sheu SS. Regulation of mitochondrial bioenergetics by the non-canonical roles of mitochondrial dynamics proteins in the heart. Biochim Biophys Acta. 2017 Sep 14. PMID: 28918113.
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    20. Mishra J, Jhun BS, Hurst S, O-Uchi J, Csordás G, Sheu SS. The Mitochondrial Ca2+ Uniporter: Structure, Function, and Pharmacology. Handb Exp Pharmacol. 2017 Feb 14. PMID: 28194521.
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    21. Zhang H, Wang P, Bisetto S, Yoon Y, Chen Q, Sheu SS, Wang W. A novel fission-independent role of dynamin-related protein 1 in cardiac mitochondrial respiration. Cardiovasc Res. 2016 Oct 29. PMID: 27794519.
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    22. De La Fuente S, Fernandez-Sanz C, Vail C, Agra EJ, Holmstrom K, Sun J, Mishra J, Williams D, Finkel T, Murphy E, Joseph SK, Sheu SS, Csordás G. Strategic Positioning and Biased Activity of the Mitochondrial Calcium Uniporter in Cardiac Muscle. J Biol Chem. 2016 Oct 28; 291(44):23343-23362. PMID: 27637331.
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    23. Hurst S, Hoek J, Sheu SS. Mitochondrial Ca2+ and regulation of the permeability transition pore. J Bioenerg Biomembr. 2017 Feb; 49(1):27-47. PMID: 27497945.
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    24. Wang W, Gong G, Wang X, Wei-LaPierre L, Cheng H, Dirksen R, Sheu SS. Mitochondrial Flash: Integrative Reactive Oxygen Species and pH Signals in Cell and Organelle Biology. Antioxid Redox Signal. 2016 Sep 20; 25(9):534-49. PMID: 27245241.
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    25. Jhun BS, Mishra J, Monaco S, Fu D, Jiang W, Sheu SS, O-Uchi J. The mitochondrial Ca2+ uniporter: regulation by auxiliary subunits and signal transduction pathways. Am J Physiol Cell Physiol. 2016 Jul 1; 311(1):C67-80. PMID: 27122161.
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    26. Gong G, Liu X, Zhang H, Sheu SS, Wang W. Mitochondrial flash as a novel biomarker of mitochondrial respiration in the heart. Am J Physiol Heart Circ Physiol. 2015 Oct; 309(7):H1166-77. PMID: 26276820.
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    27. O-Uchi J, Sorenson J, Jhun BS, Mishra J, Hurst S, Williams K, Sheu SS, Lopes CM. Isoform-specific dynamic translocation of PKC by a1-adrenoceptor stimulation in live cells. Biochem Biophys Res Commun. 2015 Aug 12. PMID: 26277396.
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    28. Fujiwara K, Sheu SS. Mitochondrial dynamics regulate neointima formation. Cardiovasc Res. 2015 May 1; 106(2):175-7. PMID: 25800033.
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    29. Pan S, Wang N, Bisetto S, Yi B, Sheu SS. Downregulation of adenine nucleotide translocator 1 exacerbates tumor necrosis factor-a-mediated cardiac inflammatory responses. Am J Physiol Heart Circ Physiol. 2015 Jan 1; 308(1):H39-48. PMID: 25380814.
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    30. Cheng H, Wang W, Wang X, Sheu SS, Dirksen RT, Dong MQ. Cheng et al. reply. Nature. 2014 Oct 22; 514(7523):E14-5. PMID: 25341791.
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    31. Jakob R, Beutner G, Sharma VK, Duan Y, Gross RA, Hurst S, Jhun BS, O-Uchi J, Sheu SS. Molecular and functional identification of a mitochondrial ryanodine receptor in neurons. Neurosci Lett. 2014 Jul 11; 575:7-12. PMID: 24861510.
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    32. O-Uchi J, Jhun BS, Xu S, Hurst S, Raffaello A, Liu X, Yi B, Zhang H, Gross P, Mishra J, Ainbinder A, Kettlewell S, Smith GL, Dirksen RT, Wang W, Rizzuto R, Sheu SS. Adrenergic signaling regulates mitochondrial Ca2+ uptake through Pyk2-dependent tyrosine phosphorylation of the mitochondrial Ca2+ uniporter Antioxid Redox Signal. 2014 May 7. PMID: 24800979.
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    33. Eyenga P, Roussel D, Morel J, Rey B, Romestaing C, Teulier L, Sheu SS, Goudable J, Négrier C, Viale JP. Early septic shock induces loss of oxidative phosphorylation yield plasticity in liver mitochondria. J Physiol Biochem. 2014 Jun; 70(2):285-96. PMID: 24570093.
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    34. O-Uchi J, Ryu SY, Jhun BS, Hurst S, Sheu SS. Mitochondrial Ion Channels/Transporters as Sensors and Regulators of Cellular Redox Signaling. Antioxid Redox Signal. 2014 Feb 3. PMID: 24180309.
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    35. Sokolova N, Pan S, Provazza S, Beutner G, Vendelin M, Birkedal R, Sheu SS. ADP Protects Cardiac Mitochondria under Severe Oxidative Stress. PLoS One. 2013; 8(12):e83214. PMID: 24349464.
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    36. O-Uchi J, Jhun BS, Hurst S, Bisetto S, Gross P, Chen M, Kettlewell S, Park J, Oyamada H, Smith GL, Murayama T, Sheu SS. Overexpression of ryanodine receptor type 1 enhances mitochondrial fragmentation and Ca2+-induced ATP production in cardiac H9c2 myoblasts. Am J Physiol Heart Circ Physiol. 2013 Dec; 305(12):H1736-51. PMID: 24124188.
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    37. Chen M, Sato PY, Chuprun JK, Peroutka RJ, Otis NJ, Ibetti J, Pan S, Sheu SS, Gao E, Koch WJ. Prodeath signaling of g protein-coupled receptor kinase 2 in cardiac myocytes after ischemic stress occurs via extracellular signal-regulated kinase-dependent heat shock protein 90-mediated mitochondrial targeting. Circ Res. 2013 Apr 12; 112(8):1121-34. PMID: 23467820.
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    38. Wei-Lapierre L, Gong G, Gerstner BJ, Ducreux S, Yule DI, Pouvreau S, Wang X, Sheu SS, Cheng H, Dirksen RT, Wang W. Respective Contribution of Mitochondrial Superoxide and pH to Mitochondria-targeted Circularly Permuted Yellow Fluorescent Protein (mt-cpYFP) Flash Activity. J Biol Chem. 2013 Apr 12; 288(15):10567-77. PMID: 23457298.
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    39. O-Uchi J, Komukai K, Kusakari Y, Morimoto S, Kawai M, Jhun BS, Hurst S, Hongo K, Sheu SS, Kurihara S. Alpha1-adrenenoceptor stimulation inhibits cardiac excitation-contraction coupling through tyrosine phosphorylation of beta1-adrenoceptor. Biochem Biophys Res Commun. 2013 Apr 5; 433(2):188-93. PMID: 23454381.
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    40. Sheu SS, Dirksen RT, Pugh EN. Perspectives on: SGP symposium on mitochondrial physiology and medicine: mitochondria take center stage. J Gen Physiol. 2012 Jun; 139(6):391-3. PMID: 22641633.
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    41. O-Uchi J, Pan S, Sheu SS. Perspectives on: SGP symposium on mitochondrial physiology and medicine: molecular identities of mitochondrial Ca2+ influx mechanism: updated passwords for accessing mitochondrial Ca2+-linked health and disease. J Gen Physiol. 2012 Jun; 139(6):435-43. PMID: 22641638.
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    42. Sheu SS, Dirksen RT, Pugh EN. The 65th Symposium of the Society for General Physiologists: energizing research in mitochondrial physiology and medicine. J Gen Physiol. 2011 Dec; 138(6):563-7. PMID: 22124113.
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    43. Csordás G, Várnai P, Golenár T, Sheu SS, Hajnóczky G. Calcium transport across the inner mitochondrial membrane: molecular mechanisms and pharmacology. Mol Cell Endocrinol. 2012 Apr 28; 353(1-2):109-13. PMID: 22123069.
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    44. Hom JR, Quintanilla RA, Hoffman DL, de Mesy Bentley KL, Molkentin JD, Sheu SS, Porter GA. The permeability transition pore controls cardiac mitochondrial maturation and myocyte differentiation. Dev Cell. 2011 Sep 13; 21(3):469-78. PMID: 21920313.
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    45. Huang Z, Zhang W, Fang H, Zheng M, Wang X, Xu J, Cheng H, Gong G, Wang W, Dirksen RT, Sheu SS. Response to "A critical evaluation of cpYFP as a probe for superoxide". Free Radic Biol Med. 2011 Nov 15; 51(10):1937-40. PMID: 21925593.
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    46. Pan S, Ryu SY, Sheu SS. Distinctive characteristics and functions of multiple mitochondrial Ca2+ influx mechanisms. Sci China Life Sci. 2011 Aug; 54(8):763-9. PMID: 21786199.
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    47. Wei L, Salahura G, Boncompagni S, Kasischke KA, Protasi F, Sheu SS, Dirksen RT. Mitochondrial superoxide flashes: metabolic biomarkers of skeletal muscle activity and disease. FASEB J. 2011 Sep; 25(9):3068-78. PMID: 21646399.
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    48. Porter GA, Hom J, Hoffman D, Quintanilla R, de Mesy Bentley K, Sheu SS. Bioenergetics, mitochondria, and cardiac myocyte differentiation. Prog Pediatr Cardiol. 2011 May; 31(2):75-81. PMID: 21603067.
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    49. Ryu SY, Beutner G, Kinnally KW, Dirksen RT, Sheu SS. Single channel characterization of the mitochondrial ryanodine receptor in heart mitoplasts. J Biol Chem. 2011 Jun 17; 286(24):21324-9. PMID: 21524998.
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    50. Hom J, Yu T, Yoon Y, Porter G, Sheu SS. Regulation of mitochondrial fission by intracellular Ca2+ in rat ventricular myocytes. Biochim Biophys Acta. 2010 Jun-Jul; 1797(6-7):913-21. PMID: 20347716.
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    51. Ryu SY, Beutner G, Dirksen RT, Kinnally KW, Sheu SS. Mitochondrial ryanodine receptors and other mitochondrial Ca2+ permeable channels. FEBS Lett. 2010 May 17; 584(10):1948-55. PMID: 20096690.
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    52. Kalifa L, Beutner G, Phadnis N, Sheu SS, Sia EA. Evidence for a role of FEN1 in maintaining mitochondrial DNA integrity. DNA Repair (Amst). 2009 Oct 2; 8(10):1242-9. PMID: 19699691.
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    53. Hom J, Sheu SS. Morphological dynamics of mitochondria--a special emphasis on cardiac muscle cells. J Mol Cell Cardiol. 2009 Jun; 46(6):811-20. PMID: 19281816.
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    54. Ingraham CA, Burwell LS, Skalska J, Brookes PS, Howell RL, Sheu SS, Pinkert CA. NDUFS4: creation of a mouse model mimicking a Complex I disorder. Mitochondrion. 2009 Jun; 9(3):204-10. PMID: 19460290.
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    55. Gunter TE, Sheu SS. Characteristics and possible functions of mitochondrial Ca(2+) transport mechanisms. Biochim Biophys Acta. 2009 Nov; 1787(11):1291-308. PMID: 19161975.
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    56. Feissner RF, Skalska J, Gaum WE, Sheu SS. Crosstalk signaling between mitochondrial Ca2+ and ROS. Front Biosci. 2009; 14:1197-218. PMID: 19273125.
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    57. Sheu SS, Wang W, Cheng H, Dirksen RT. Superoxide flashes: illuminating new insights into cardiac ischemia/reperfusion injury. Future Cardiol. 2008 Nov 1; 4(6):551-554. PMID: 19649173.
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    58. Daubert JP, Sheu SS. Mystery of biphasic defibrillation waveform efficacy is it calcium? J Am Coll Cardiol. 2008 Sep 2; 52(10):836-8. PMID: 18755346.
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    59. Wang W, Fang H, Groom L, Cheng A, Zhang W, Liu J, Wang X, Li K, Han P, Zheng M, Yin J, Wang W, Mattson MP, Kao JP, Lakatta EG, Sheu SS, Ouyang K, Chen J, Dirksen RT, Cheng H. Superoxide flashes in single mitochondria. Cell. 2008 Jul 25; 134(2):279-90. PMID: 18662543.
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    60. Mao W, Iwai C, Liu J, Sheu SS, Fu M, Liang CS. Darbepoetin alfa exerts a cardioprotective effect in autoimmune cardiomyopathy via reduction of ER stress and activation of the PI3K/Akt and STAT3 pathways. J Mol Cell Cardiol. 2008 Aug; 45(2):250-60. PMID: 18586265.
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    61. Yu T, Sheu SS, Robotham JL, Yoon Y. Mitochondrial fission mediates high glucose-induced cell death through elevated production of reactive oxygen species. Cardiovasc Res. 2008 Jul 15; 79(2):341-51. PMID: 18440987.
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    62. Liu J, Mao W, Iwai C, Fukuoka S, Vulapalli R, Huang H, Wang T, Sharma VK, Sheu SS, Fu M, Liang CS. Adoptive passive transfer of rabbit beta1-adrenoceptor peptide immune cardiomyopathy into the Rag2-/- mouse: participation of the ER stress. J Mol Cell Cardiol. 2008 Feb; 44(2):304-14. PMID: 18155231.
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    63. Duan Y, Gross RA, Sheu SS. Ca2+-dependent generation of mitochondrial reactive oxygen species serves as a signal for poly(ADP-ribose) polymerase-1 activation during glutamate excitotoxicity. J Physiol. 2007 Dec 15; 585(Pt 3):741-58. PMID: 17947304.
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    64. Hom JR, Gewandter JS, Michael L, Sheu SS, Yoon Y. Thapsigargin induces biphasic fragmentation of mitochondria through calcium-mediated mitochondrial fission and apoptosis. J Cell Physiol. 2007 Aug; 212(2):498-508. PMID: 17443673.
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    65. Mao W, Fukuoka S, Iwai C, Liu J, Sharma VK, Sheu SS, Fu M, Liang CS. Cardiomyocyte apoptosis in autoimmune cardiomyopathy: mediated via endoplasmic reticulum stress and exaggerated by norepinephrine. Am J Physiol Heart Circ Physiol. 2007 Sep; 293(3):H1636-45. PMID: 17545481.
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    66. Venkatesh K, Chivatakarn O, Sheu SS, Giger RJ. Molecular dissection of the myelin-associated glycoprotein receptor complex reveals cell type-specific mechanisms for neurite outgrowth inhibition. J Cell Biol. 2007 May 7; 177(3):393-9. PMID: 17470639.
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    67. Altschafl BA, Beutner G, Sharma VK, Sheu SS, Valdivia HH. The mitochondrial ryanodine receptor in rat heart: a pharmaco-kinetic profile. Biochim Biophys Acta. 2007 Jul; 1768(7):1784-95. PMID: 17499575.
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    68. Lin L, Sharma VK, Sheu SS. Mechanisms of reduced mitochondrial Ca2+ accumulation in failing hamster heart. Pflugers Arch. 2007 Jun; 454(3):395-402. PMID: 17387508.
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    69. Maekawa N, Abe J, Shishido T, Itoh S, Ding B, Sharma VK, Sheu SS, Blaxall BC, Berk BC. Inhibiting p90 ribosomal S6 kinase prevents (Na+)-H+ exchanger-mediated cardiac ischemia-reperfusion injury. Circulation. 2006 May 30; 113(21):2516-23. PMID: 16717153.
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    70. Anders MW, Robotham JL, Sheu SS. Mitochondria: new drug targets for oxidative stress-induced diseases. Expert Opin Drug Metab Toxicol. 2006 Feb; 2(1):71-9. PMID: 16863469.
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    71. Sheu SS, Nauduri D, Anders MW. Targeting antioxidants to mitochondria: a new therapeutic direction. Biochim Biophys Acta. 2006 Feb; 1762(2):256-65. PMID: 16352423.
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    72. Brdiczka DG, Zorov DB, Sheu SS. Mitochondrial contact sites: their role in energy metabolism and apoptosis. Biochim Biophys Acta. 2006 Feb; 1762(2):148-63. PMID: 16324828.
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    73. Beutner G, Sharma VK, Lin L, Ryu SY, Dirksen RT, Sheu SS. Type 1 ryanodine receptor in cardiac mitochondria: transducer of excitation-metabolism coupling. Biochim Biophys Acta. 2005 Nov 10; 1717(1):1-10. PMID: 16246297.
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    74. Watanabe T, Suzuki J, Yamawaki H, Sharma VK, Sheu SS, Berk BC. Losartan metabolite EXP3179 activates Akt and endothelial nitric oxide synthase via vascular endothelial growth factor receptor-2 in endothelial cells: angiotensin II type 1 receptor-independent effects of EXP3179. Circulation. 2005 Sep 20; 112(12):1798-805. PMID: 16172287.
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    75. Itoh S, Lemay S, Osawa M, Che W, Duan Y, Tompkins A, Brookes PS, Sheu SS, Abe J. Mitochondrial Dok-4 recruits Src kinase and regulates NF-kappaB activation in endothelial cells. J Biol Chem. 2005 Jul 15; 280(28):26383-96. PMID: 15855164.
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    76. Brookes PS, Yoon Y, Robotham JL, Anders MW, Sheu SS. Calcium, ATP, and ROS: a mitochondrial love-hate triangle. Am J Physiol Cell Physiol. 2004 Oct; 287(4):C817-33. PMID: 15355853.
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    77. He X, Liu Y, Sharma V, Dirksen RT, Waugh R, Sheu SS, Min W. ASK1 associates with troponin T and induces troponin T phosphorylation and contractile dysfunction in cardiomyocytes. Am J Pathol. 2003 Jul; 163(1):243-51. PMID: 12819028.
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    78. Kriscenski-Perry E, Durham HD, Sheu SS, Figlewicz DA. Synergistic effects of low level stressors in an oxidative damage model of spinal motor neuron degeneration. Amyotroph Lateral Scler Other Motor Neuron Disord. 2002 Sep; 3(3):151-7. PMID: 12495577.
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    79. Alano CC, Beutner G, Dirksen RT, Gross RA, Sheu SS. Mitochondrial permeability transition and calcium dynamics in striatal neurons upon intense NMDA receptor activation. J Neurochem. 2002 Feb; 80(3):531-8. PMID: 11905998.
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