Thomas Jefferson University

Shey-Shing Sheu

TitleProfessor
InstitutionThomas Jefferson University
DepartmentCenter for Translational Medic
Address1020 Locust St.
Philadelphia PA 19107
Phone215-503-5152
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Bernardi P, Gerle C, Halestrap AP, Jonas EA, Karch J, Mnatsakanyan N, Pavlov E, Sheu SS, Soukas AA. Identity, structure, and function of the mitochondrial permeability transition pore: controversies, consensus, recent advances, and future directions. Cell Death Differ. 2023 08; 30(8):1869-1885. PMID: 37460667.
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    2. Nichtov? Z, Fernandez-Sanz C, De La Fuente S, Yuan Y, Hurst S, Lanvermann S, Tsai HY, Weaver D, Baggett A, Thompson C, Bouchet-Marquis C, V?rnai P, Seifert EL, Dorn GW, Sheu SS, Csord?s G. Enhanced Mitochondria-SR Tethering Triggers Adaptive Cardiac Muscle Remodeling. Circ Res. 2023 05 26; 132(11):e171-e187. PMID: 37057625.
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    3. Yoon Y, Lee H, Federico M, Sheu SS. Non-conventional mitochondrial permeability transition: Its regulation by mitochondrial dynamics. Biochim Biophys Acta Bioenerg. 2023 01 01; 1864(1):148914. PMID: 36063902.
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    4. Eyenga P, Rey B, Eyenga L, Sheu SS. Regulation of Oxidative Phosphorylation of Liver Mitochondria in Sepsis. Cells. 2022 05 10; 11(10). PMID: 35626633.
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    5. Bou-Teen D, Fernandez-Sanz C, Miro-Casas E, Nichtova Z, Bonzon-Kulichenko E, Cas?s K, Inserte J, Rodriguez-Sinovas A, Benito B, Sheu SS, V?zquez J, Ferreira-Gonz?lez I, Ruiz-Meana M. Defective dimerization of FoF1-ATP synthase secondary to glycation favors mitochondrial energy deficiency in cardiomyocytes during aging. Aging Cell. 2022 03; 21(3):e13564. PMID: 35233924.
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    6. Wang P, Xu S, Xu J, Xin Y, Lu Y, Zhang H, Zhou B, Xu H, Sheu SS, Tian R, Wang W. Elevated MCU Expression by CaMKIIdB Limits Pathological Cardiac Remodeling. Circulation. 2022 04 05; 145(14):1067-1083. PMID: 35167328.
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    7. Bruno NE, Nwachukwu JC, Hughes DC, Srinivasan S, Hawkins R, Sturgill D, Hager GL, Hurst S, Sheu SS, Bodine SC, Conkright MD, Nettles KW. Activation of Crtc2/Creb1 in skeletal muscle enhances weight loss during intermittent fasting. FASEB J. 2021 12; 35(12):e21999. PMID: 34748223.
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    8. Federico M, De la Fuente S, Palomeque J, Sheu SS. The role of mitochondria in metabolic disease: a special emphasis on heart dysfunction. J Physiol. 2021 07; 599(14):3477-3493. PMID: 33932959.
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    9. Eyenga P, Roussel D, Rey B, Ndille P, Teulier L, Eyenga F, Romestaing C, Morel J, Gueguen-Chaignon V, Sheu SS. Mechanical ventilation preserves diaphragm mitochondrial function in a rat sepsis model. Intensive Care Med Exp. 2021 Apr 07; 9(1):19. PMID: 33825987.
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    10. Neginskaya MA, Pavlov EV, Sheu SS. Electrophysiological properties of the mitochondrial permeability transition pores: Channel diversity and disease implication. Biochim Biophys Acta Bioenerg. 2021 03 01; 1862(3):148357. PMID: 33359307.
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    11. Wang W, Sheu SS. Unsolved mysteries and controversies of mitochondria in the heart - A virtual special issue in JMCC: Part IV. J Mol Cell Cardiol. 2021 02; 151:72-73. PMID: 33221273.
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    12. Hurst S, Gonnot F, Dia M, Crola Da Silva C, Gomez L, Sheu SS. Phosphorylation of cyclophilin D at serine 191 regulates mitochondrial permeability transition pore opening and cell death after ischemia-reperfusion. Cell Death Dis. 2020 08 19; 11(8):661. PMID: 32814770.
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    13. Wang W, Sheu SS. Unsolved mysteries and controversies of mitochondria in the heart- A Virtual Special Issue in JMCC: Part III. J Mol Cell Cardiol. 2020 07; 144:A1-A2. PMID: 32603737.
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    14. Wang W, Sheu SS. Unsolved mysteries and controversies of mitochondria in the heart - A virtual special issue in JMCC: Part II. J Mol Cell Cardiol. 2020 06; 143:162. PMID: 32473158.
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    15. Wang W, Sheu SS. Unsolved mysteries and controversies of mitochondria in the heart - A virtual special issue in JMCC. J Mol Cell Cardiol. 2020 05; 142:137. PMID: 32311414.
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    16. Lee H, Smith SB, Sheu SS, Yoon Y. The short variant of optic atrophy 1 (OPA1) improves cell survival under oxidative stress. J Biol Chem. 2020 05 08; 295(19):6543-6560. PMID: 32245890.
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    17. Hu Q, Zhang H, Guti?rrez Cort?s N, Wu D, Wang P, Zhang J, Mattison JA, Smith E, Bettcher LF, Wang M, Lakatta EG, Sheu SS, Wang W. Increased Drp1 Acetylation by Lipid Overload Induces Cardiomyocyte Death and Heart Dysfunction. Circ Res. 2020 02 14; 126(4):456-470. PMID: 31896304.
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    18. Tian R, Colucci WS, Arany Z, Bachschmid MM, Ballinger SW, Boudina S, Bruce JE, Busija DW, Dikalov S, Dorn GW, Galis ZS, Gottlieb RA, Kelly DP, Kitsis RN, Kohr MJ, Levy D, Lewandowski ED, McClung JM, Mochly-Rosen D, O'Brien KD, O'Rourke B, Park JY, Ping P, Sack MN, Sheu SS, Shi Y, Shiva S, Wallace DC, Weiss RG, Vernon HJ, Wong R, Schwartz Longacre L. Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure?A Report from the 2018 National Heart, Lung, and Blood Institute Workshop Circulation. 2019 10 01; 140(14):1205-1216. PMID: 31769940.
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    19. Fernandez-Sanz C, De la Fuente S, Sheu SS. Mitochondrial Ca2+ concentrations in live cells: quantification methods and discrepancies. FEBS Lett. 2019 07; 593(13):1528-1541. PMID: 31058316.
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    20. Dirksen RT, Wang W, Sheu SS. Introduction. Arch Biochem Biophys. 2019 07 15; 669:31. PMID: 31112707.
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    21. Hurst S, Baggett A, Csordas G, Sheu SS. SPG7 targets the m-AAA protease complex to process MCU for uniporter assembly, Ca2+ influx, and regulation of mitochondrial permeability transition pore opening. J Biol Chem. 2019 07 12; 294(28):10807-10818. PMID: 31097542.
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    22. De la Fuente S, Sheu SS. SR-mitochondria communication in adult cardiomyocytes: A close relationship where the Ca2+ has a lot to say. Arch Biochem Biophys. 2019 03 15; 663:259-268. PMID: 30685253.
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    23. Miller BA, Wang J, Song J, Zhang XQ, Hirschler-Laszkiewicz I, Shanmughapriya S, Tomar D, Rajan S, Feldman AM, Madesh M, Sheu SS, Cheung JY. Trpm2 enhances physiological bioenergetics and protects against pathological oxidative cardiac injury: Role of Pyk2 phosphorylation. J Cell Physiol. 2019 Sep; 234(9):15048-15060. PMID: 30637731.
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    24. Wang P, Fernandez-Sanz C, Wang W, Sheu SS. Why don't mice lacking the mitochondrial Ca2+ uniporter experience an energy crisis? J Physiol. 2020 04; 598(7):1307-1326. PMID: 30218574.
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    25. De La Fuente S, Lambert JP, Nichtova Z, Fernandez Sanz C, Elrod JW, Sheu SS, Csord?s G. Spatial Separation of Mitochondrial Calcium Uptake and Extrusion for Energy-Efficient Mitochondrial Calcium Signaling in the Heart. Cell Rep. 2018 09 18; 24(12):3099-3107.e4. PMID: 30231993.
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    26. Eyenga P, Roussel D, Morel J, Rey B, Romestaing C, Gueguen-Chaignon V, Sheu SS, Viale JP. Time course of liver mitochondrial function and intrinsic changes in oxidative phosphorylation in a rat model of sepsis. Intensive Care Med Exp. 2018 Sep 05; 6(1):31. PMID: 30187255.
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    27. Jhun BS, O-Uchi J, Adaniya SM, Mancini TJ, Cao JL, King ME, Landi AK, Ma H, Shin M, Yang D, Xu X, Yoon Y, Choudhary G, Clements RT, Mende U, Sheu SS. Protein kinase D activation induces mitochondrial fragmentation and dysfunction in cardiomyocytes. J Physiol. 2018 03 01; 596(5):827-855. PMID: 29313986.
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    28. Wang W, Fernandez-Sanz C, Sheu SS. Regulation of mitochondrial bioenergetics by the non-canonical roles of mitochondrial dynamics proteins in the heart. Biochim Biophys Acta Mol Basis Dis. 2018 May; 1864(5 Pt B):1991-2001. PMID: 28918113.
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    29. Mishra J, Jhun BS, Hurst S, O-Uchi J, Csord?s G, Sheu SS. The Mitochondrial Ca2+ Uniporter: Structure, Function, and Pharmacology. Handb Exp Pharmacol. 2017; 240:129-156. PMID: 28194521.
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    30. Zhang H, Wang P, Bisetto S, Yoon Y, Chen Q, Sheu SS, Wang W. A novel fission-independent role of dynamin-related protein 1 in cardiac mitochondrial respiration. Cardiovasc Res. 2017 02; 113(2):160-170. PMID: 27794519.
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    31. De La Fuente S, Fernandez-Sanz C, Vail C, Agra EJ, Holmstrom K, Sun J, Mishra J, Williams D, Finkel T, Murphy E, Joseph SK, Sheu SS, Csord?s G. Strategic Positioning and Biased Activity of the Mitochondrial Calcium Uniporter in Cardiac Muscle. J Biol Chem. 2016 10 28; 291(44):23343-23362. PMID: 27637331.
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    32. Hurst S, Hoek J, Sheu SS. Mitochondrial Ca2+ and regulation of the permeability transition pore. J Bioenerg Biomembr. 2017 Feb; 49(1):27-47. PMID: 27497945.
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    33. Wang W, Gong G, Wang X, Wei-LaPierre L, Cheng H, Dirksen R, Sheu SS. Mitochondrial Flash: Integrative Reactive Oxygen Species and pH Signals in Cell and Organelle Biology. Antioxid Redox Signal. 2016 09 20; 25(9):534-49. PMID: 27245241.
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    34. Jhun BS, Mishra J, Monaco S, Fu D, Jiang W, Sheu SS, O-Uchi J. The mitochondrial Ca2+ uniporter: regulation by auxiliary subunits and signal transduction pathways. Am J Physiol Cell Physiol. 2016 07 01; 311(1):C67-80. PMID: 27122161.
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    35. Gomez L, Thiebaut PA, Paillard M, Ducreux S, Abrial M, Crola Da Silva C, Durand A, Alam MR, Van Coppenolle F, Sheu SS, Ovize M. The SR/ER-mitochondria calcium crosstalk is regulated by GSK3? during reperfusion injury. Cell Death Differ. 2015 Nov; 22(11):1890. PMID: 26434983.
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    36. Gong G, Liu X, Zhang H, Sheu SS, Wang W. Mitochondrial flash as a novel biomarker of mitochondrial respiration in the heart. Am J Physiol Heart Circ Physiol. 2015 Oct; 309(7):H1166-77. PMID: 26276820.
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    37. O-Uchi J, Sorenson J, Jhun BS, Mishra J, Hurst S, Williams K, Sheu SS, Lopes CM. Isoform-specific dynamic translocation of PKC by a1-adrenoceptor stimulation in live cells. Biochem Biophys Res Commun. 2015 Sep 25; 465(3):464-70. PMID: 26277396.
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    38. Gomez L, Thiebaut PA, Paillard M, Ducreux S, Abrial M, Crola Da Silva C, Durand A, Alam MR, Van Coppenolle F, Sheu SS, Ovize M. The SR/ER-mitochondria calcium crosstalk is regulated by GSK3? during reperfusion injury. Cell Death Differ. 2016 Feb; 23(2):313-22. PMID: 26206086.
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    39. Fujiwara K, Sheu SS. Mitochondrial dynamics regulate neointima formation. Cardiovasc Res. 2015 May 01; 106(2):175-7. PMID: 25800033.
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    40. Pan S, Wang N, Bisetto S, Yi B, Sheu SS. Downregulation of adenine nucleotide translocator 1 exacerbates tumor necrosis factor-a-mediated cardiac inflammatory responses. Am J Physiol Heart Circ Physiol. 2015 Jan 01; 308(1):H39-48. PMID: 25380814.
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    41. Cheng H, Wang W, Wang X, Sheu SS, Dirksen RT, Dong MQ. Cheng et al. reply. Nature. 2014 Oct 23; 514(7523):E14-5. PMID: 25341791.
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    42. O-Uchi J, Jhun BS, Xu S, Hurst S, Raffaello A, Liu X, Yi B, Zhang H, Gross P, Mishra J, Ainbinder A, Kettlewell S, Smith GL, Dirksen RT, Wang W, Rizzuto R, Sheu SS. Adrenergic signaling regulates mitochondrial Ca2+ uptake through Pyk2-dependent tyrosine phosphorylation of the mitochondrial Ca2+ uniporter. Antioxid Redox Signal. 2014 Aug 20; 21(6):863-79. PMID: 24800979.
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    43. Jakob R, Beutner G, Sharma VK, Duan Y, Gross RA, Hurst S, Jhun BS, O-Uchi J, Sheu SS. Molecular and functional identification of a mitochondrial ryanodine receptor in neurons. Neurosci Lett. 2014 Jul 11; 575:7-12. PMID: 24861510.
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    44. Eyenga P, Roussel D, Morel J, Rey B, Romestaing C, Teulier L, Sheu SS, Goudable J, N?grier C, Viale JP. Early septic shock induces loss of oxidative phosphorylation yield plasticity in liver mitochondria. J Physiol Biochem. 2014 Jun; 70(2):285-96. PMID: 24570093.
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    45. O-Uchi J, Ryu SY, Jhun BS, Hurst S, Sheu SS. Mitochondrial ion channels/transporters as sensors and regulators of cellular redox signaling. Antioxid Redox Signal. 2014 Aug 20; 21(6):987-1006. PMID: 24180309.
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    46. Sokolova N, Pan S, Provazza S, Beutner G, Vendelin M, Birkedal R, Sheu SS. ADP protects cardiac mitochondria under severe oxidative stress. PLoS One. 2013; 8(12):e83214. PMID: 24349464.
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    47. O-Uchi J, Jhun BS, Hurst S, Bisetto S, Gross P, Chen M, Kettlewell S, Park J, Oyamada H, Smith GL, Murayama T, Sheu SS. Overexpression of ryanodine receptor type 1 enhances mitochondrial fragmentation and Ca2+-induced ATP production in cardiac H9c2 myoblasts. Am J Physiol Heart Circ Physiol. 2013 Dec; 305(12):H1736-51. PMID: 24124188.
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    48. Chen M, Sato PY, Chuprun JK, Peroutka RJ, Otis NJ, Ibetti J, Pan S, Sheu SS, Gao E, Koch WJ. Prodeath signaling of G protein-coupled receptor kinase 2 in cardiac myocytes after ischemic stress occurs via extracellular signal-regulated kinase-dependent heat shock protein 90-mediated mitochondrial targeting. Circ Res. 2013 Apr 12; 112(8):1121-34. PMID: 23467820.
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    49. Wei-LaPierre L, Gong G, Gerstner BJ, Ducreux S, Yule DI, Pouvreau S, Wang X, Sheu SS, Cheng H, Dirksen RT, Wang W. Respective contribution of mitochondrial superoxide and pH to mitochondria-targeted circularly permuted yellow fluorescent protein (mt-cpYFP) flash activity. J Biol Chem. 2013 Apr 12; 288(15):10567-77. PMID: 23457298.
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    50. O-Uchi J, Komukai K, Kusakari Y, Morimoto S, Kawai M, Jhun BS, Hurst S, Hongo K, Sheu SS, Kurihara S. Alpha1-adrenenoceptor stimulation inhibits cardiac excitation-contraction coupling through tyrosine phosphorylation of beta1-adrenoceptor. Biochem Biophys Res Commun. 2013 Apr 05; 433(2):188-93. PMID: 23454381.
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    51. Sheu SS, Dirksen RT, Pugh EN. Perspectives on: SGP symposium on mitochondrial physiology and medicine: mitochondria take center stage. J Gen Physiol. 2012 Jun; 139(6):391-3. PMID: 22641633.
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    52. O-Uchi J, Pan S, Sheu SS. Perspectives on: SGP symposium on mitochondrial physiology and medicine: molecular identities of mitochondrial Ca2+ influx mechanism: updated passwords for accessing mitochondrial Ca2+-linked health and disease. J Gen Physiol. 2012 Jun; 139(6):435-43. PMID: 22641638.
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    53. Sheu SS, Dirksen RT, Pugh EN. The 65th Symposium of the Society for General Physiologists: energizing research in mitochondrial physiology and medicine. J Gen Physiol. 2011 Dec; 138(6):563-7. PMID: 22124113.
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    54. Csord?s G, V?rnai P, Golen?r T, Sheu SS, Hajn?czky G. Calcium transport across the inner mitochondrial membrane: molecular mechanisms and pharmacology. Mol Cell Endocrinol. 2012 Apr 28; 353(1-2):109-13. PMID: 22123069.
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    55. Hom JR, Quintanilla RA, Hoffman DL, de Mesy Bentley KL, Molkentin JD, Sheu SS, Porter GA. The permeability transition pore controls cardiac mitochondrial maturation and myocyte differentiation. Dev Cell. 2011 Sep 13; 21(3):469-78. PMID: 21920313.
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    56. Huang Z, Zhang W, Fang H, Zheng M, Wang X, Xu J, Cheng H, Gong G, Wang W, Dirksen RT, Sheu SS. Response to "A critical evaluation of cpYFP as a probe for superoxide". Free Radic Biol Med. 2011 Nov 15; 51(10):1937-40. PMID: 21925593.
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    57. Pan S, Ryu SY, Sheu SS. Distinctive characteristics and functions of multiple mitochondrial Ca2+ influx mechanisms. Sci China Life Sci. 2011 Aug; 54(8):763-9. PMID: 21786199.
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    58. Wei L, Salahura G, Boncompagni S, Kasischke KA, Protasi F, Sheu SS, Dirksen RT. Mitochondrial superoxide flashes: metabolic biomarkers of skeletal muscle activity and disease. FASEB J. 2011 Sep; 25(9):3068-78. PMID: 21646399.
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    59. Porter GA, Hom J, Hoffman D, Quintanilla R, de Mesy Bentley K, Sheu SS. Bioenergetics, mitochondria, and cardiac myocyte differentiation. Prog Pediatr Cardiol. 2011 May; 31(2):75-81. PMID: 21603067.
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    60. Ryu SY, Beutner G, Kinnally KW, Dirksen RT, Sheu SS. Single channel characterization of the mitochondrial ryanodine receptor in heart mitoplasts. J Biol Chem. 2011 Jun 17; 286(24):21324-9. PMID: 21524998.
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    61. Hom J, Yu T, Yoon Y, Porter G, Sheu SS. Regulation of mitochondrial fission by intracellular Ca2+ in rat ventricular myocytes. Biochim Biophys Acta. 2010 Jun-Jul; 1797(6-7):913-21. PMID: 20347716.
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    62. Ryu SY, Beutner G, Dirksen RT, Kinnally KW, Sheu SS. Mitochondrial ryanodine receptors and other mitochondrial Ca2+ permeable channels. FEBS Lett. 2010 May 17; 584(10):1948-55. PMID: 20096690.
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    63. Kalifa L, Beutner G, Phadnis N, Sheu SS, Sia EA. Evidence for a role of FEN1 in maintaining mitochondrial DNA integrity. DNA Repair (Amst). 2009 Oct 02; 8(10):1242-9. PMID: 19699691.
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    64. Hom J, Sheu SS. Morphological dynamics of mitochondria--a special emphasis on cardiac muscle cells. J Mol Cell Cardiol. 2009 Jun; 46(6):811-20. PMID: 19281816.
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    65. Ingraham CA, Burwell LS, Skalska J, Brookes PS, Howell RL, Sheu SS, Pinkert CA. NDUFS4: creation of a mouse model mimicking a Complex I disorder. Mitochondrion. 2009 Jun; 9(3):204-10. PMID: 19460290.
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    66. Gunter TE, Sheu SS. Characteristics and possible functions of mitochondrial Ca(2+) transport mechanisms. Biochim Biophys Acta. 2009 Nov; 1787(11):1291-308. PMID: 19161975.
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    67. Feissner RF, Skalska J, Gaum WE, Sheu SS. Crosstalk signaling between mitochondrial Ca2+ and ROS. Front Biosci (Landmark Ed). 2009 01 01; 14(4):1197-218. PMID: 19273125.
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    68. Sheu SS, Wang W, Cheng H, Dirksen RT. Superoxide flashes: illuminating new insights into cardiac ischemia/reperfusion injury. Future Cardiol. 2008 Nov 01; 4(6):551-554. PMID: 19649173.
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    69. Daubert JP, Sheu SS. Mystery of biphasic defibrillation waveform efficacy is it calcium? J Am Coll Cardiol. 2008 Sep 02; 52(10):836-8. PMID: 18755346.
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    70. Wang W, Fang H, Groom L, Cheng A, Zhang W, Liu J, Wang X, Li K, Han P, Zheng M, Yin J, Wang W, Mattson MP, Kao JP, Lakatta EG, Sheu SS, Ouyang K, Chen J, Dirksen RT, Cheng H. Superoxide flashes in single mitochondria. Cell. 2008 Jul 25; 134(2):279-90. PMID: 18662543.
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    71. Mao W, Iwai C, Liu J, Sheu SS, Fu M, Liang CS. Darbepoetin alfa exerts a cardioprotective effect in autoimmune cardiomyopathy via reduction of ER stress and activation of the PI3K/Akt and STAT3 pathways. J Mol Cell Cardiol. 2008 Aug; 45(2):250-60. PMID: 18586265.
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    72. Yu T, Sheu SS, Robotham JL, Yoon Y. Mitochondrial fission mediates high glucose-induced cell death through elevated production of reactive oxygen species. Cardiovasc Res. 2008 Jul 15; 79(2):341-51. PMID: 18440987.
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    73. Liu J, Mao W, Iwai C, Fukuoka S, Vulapalli R, Huang H, Wang T, Sharma VK, Sheu SS, Fu M, Liang CS. Adoptive passive transfer of rabbit beta1-adrenoceptor peptide immune cardiomyopathy into the Rag2-/- mouse: participation of the ER stress. J Mol Cell Cardiol. 2008 Feb; 44(2):304-14. PMID: 18155231.
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    74. Duan Y, Gross RA, Sheu SS. Ca2+-dependent generation of mitochondrial reactive oxygen species serves as a signal for poly(ADP-ribose) polymerase-1 activation during glutamate excitotoxicity. J Physiol. 2007 Dec 15; 585(Pt 3):741-58. PMID: 17947304.
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    75. Hom JR, Gewandter JS, Michael L, Sheu SS, Yoon Y. Thapsigargin induces biphasic fragmentation of mitochondria through calcium-mediated mitochondrial fission and apoptosis. J Cell Physiol. 2007 Aug; 212(2):498-508. PMID: 17443673.
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    76. Mao W, Fukuoka S, Iwai C, Liu J, Sharma VK, Sheu SS, Fu M, Liang CS. Cardiomyocyte apoptosis in autoimmune cardiomyopathy: mediated via endoplasmic reticulum stress and exaggerated by norepinephrine. Am J Physiol Heart Circ Physiol. 2007 Sep; 293(3):H1636-45. PMID: 17545481.
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    77. Venkatesh K, Chivatakarn O, Sheu SS, Giger RJ. Molecular dissection of the myelin-associated glycoprotein receptor complex reveals cell type-specific mechanisms for neurite outgrowth inhibition. J Cell Biol. 2007 May 07; 177(3):393-9. PMID: 17470639.
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    78. Altschafl BA, Beutner G, Sharma VK, Sheu SS, Valdivia HH. The mitochondrial ryanodine receptor in rat heart: a pharmaco-kinetic profile. Biochim Biophys Acta. 2007 Jul; 1768(7):1784-95. PMID: 17499575.
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    79. Lin L, Sharma VK, Sheu SS. Mechanisms of reduced mitochondrial Ca2+ accumulation in failing hamster heart. Pflugers Arch. 2007 Jun; 454(3):395-402. PMID: 17387508.
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    80. Maekawa N, Abe J, Shishido T, Itoh S, Ding B, Sharma VK, Sheu SS, Blaxall BC, Berk BC. Inhibiting p90 ribosomal S6 kinase prevents (Na+)-H+ exchanger-mediated cardiac ischemia-reperfusion injury. Circulation. 2006 May 30; 113(21):2516-23. PMID: 16717153.
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    81. Anders MW, Robotham JL, Sheu SS. Mitochondria: new drug targets for oxidative stress-induced diseases. Expert Opin Drug Metab Toxicol. 2006 Feb; 2(1):71-9. PMID: 16863469.
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    82. Shoshan-Barmatz V, Israelson A, Brdiczka D, Sheu SS. The voltage-dependent anion channel (VDAC): function in intracellular signalling, cell life and cell death. Curr Pharm Des. 2006; 12(18):2249-70. PMID: 16787253.
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    83. Sheu SS, Nauduri D, Anders MW. Targeting antioxidants to mitochondria: a new therapeutic direction. Biochim Biophys Acta. 2006 Feb; 1762(2):256-65. PMID: 16352423.
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    84. Brdiczka DG, Zorov DB, Sheu SS. Mitochondrial contact sites: their role in energy metabolism and apoptosis. Biochim Biophys Acta. 2006 Feb; 1762(2):148-63. PMID: 16324828.
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    85. Beutner G, Sharma VK, Lin L, Ryu SY, Dirksen RT, Sheu SS. Type 1 ryanodine receptor in cardiac mitochondria: transducer of excitation-metabolism coupling. Biochim Biophys Acta. 2005 Nov 10; 1717(1):1-10. PMID: 16246297.
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    86. Watanabe T, Suzuki J, Yamawaki H, Sharma VK, Sheu SS, Berk BC. Losartan metabolite EXP3179 activates Akt and endothelial nitric oxide synthase via vascular endothelial growth factor receptor-2 in endothelial cells: angiotensin II type 1 receptor-independent effects of EXP3179. Circulation. 2005 Sep 20; 112(12):1798-805. PMID: 16172287.
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    87. Itoh S, Lemay S, Osawa M, Che W, Duan Y, Tompkins A, Brookes PS, Sheu SS, Abe J. Mitochondrial Dok-4 recruits Src kinase and regulates NF-kappaB activation in endothelial cells. J Biol Chem. 2005 Jul 15; 280(28):26383-96. PMID: 15855164.
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    88. Brookes PS, Yoon Y, Robotham JL, Anders MW, Sheu SS. Calcium, ATP, and ROS: a mitochondrial love-hate triangle. Am J Physiol Cell Physiol. 2004 Oct; 287(4):C817-33. PMID: 15355853.
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    89. He X, Liu Y, Sharma V, Dirksen RT, Waugh R, Sheu SS, Min W. ASK1 associates with troponin T and induces troponin T phosphorylation and contractile dysfunction in cardiomyocytes. Am J Pathol. 2003 Jul; 163(1):243-51. PMID: 12819028.
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    90. Kriscenski-Perry E, Durham HD, Sheu SS, Figlewicz DA. Synergistic effects of low level stressors in an oxidative damage model of spinal motor neuron degeneration. Amyotroph Lateral Scler Other Motor Neuron Disord. 2002 Sep; 3(3):151-7. PMID: 12495577.
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    91. Alano CC, Beutner G, Dirksen RT, Gross RA, Sheu SS. Mitochondrial permeability transition and calcium dynamics in striatal neurons upon intense NMDA receptor activation. J Neurochem. 2002 Feb; 80(3):531-8. PMID: 11905998.
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    92. S?nchez JA, Garc?a MC, Sharma VK, Young KC, Matlib MA, Sheu SS. Mitochondria regulate inactivation of L-type Ca2+ channels in rat heart. J Physiol. 2001 Oct 15; 536(Pt 2):387-96. PMID: 11600674.
      Citations:    
    93. DeCory HH, Piech-Dumas KM, Sheu SS, Federoff HJ, Anders MW. Efflux of glutathione conjugate of monochlorobimane from striatal and cortical neurons. Drug Metab Dispos. 2001 Oct; 29(10):1256-62. PMID: 11560867.
      Citations:    
    94. Beutner G, Sharma VK, Giovannucci DR, Yule DI, Sheu SS. Identification of a ryanodine receptor in rat heart mitochondria. J Biol Chem. 2001 Jun 15; 276(24):21482-8. PMID: 11297554.
      Citations:    
    95. Sharma VK, Ramesh V, Franzini-Armstrong C, Sheu SS. Transport of Ca2+ from sarcoplasmic reticulum to mitochondria in rat ventricular myocytes. J Bioenerg Biomembr. 2000 Feb; 32(1):97-104. PMID: 11768767.
      Citations:    
    96. H?ser J, Blatter LA, Sheu SS. Mitochondrial calcium in heart cells: beat-to-beat oscillations or slow integration of cytosolic transients? J Bioenerg Biomembr. 2000 Feb; 32(1):27-33. PMID: 11768759.
      Citations:    
    97. Sheu SS, Sharma VK. Rapid report: a novel technique for quantitative measurement of free Ca2+ concentration in rat heart mitochondria. J Physiol. 1999 Jul 15; 518 ( Pt 2):577-84. PMID: 10381602.
      Citations:    
    98. Colecraft HM, Egamino JP, Sharma VK, Sheu SS. Signaling mechanisms underlying muscarinic receptor-mediated increase in contraction rate in cultured heart cells. J Biol Chem. 1998 Nov 27; 273(48):32158-66. PMID: 9822693.
      Citations:    
    99. Ramesh V, Sharma VK, Sheu SS, Franzini-Armstrong C. Structural proximity of mitochondria to calcium release units in rat ventricular myocardium may suggest a role in Ca2+ sequestration. Ann N Y Acad Sci. 1998 Sep 16; 853:341-4. PMID: 10603975.
      Citations:    
    100. Greene JG, Sheu SS, Gross RA, Greenamyre JT. 3-Nitropropionic acid exacerbates N-methyl-D-aspartate toxicity in striatal culture by multiple mechanisms. Neuroscience. 1998 May; 84(2):503-10. PMID: 9539220.
      Citations:    
    101. Chen CH, Shyu PW, Wu SJ, Sheu SS, Desnick RJ, Hsiao KJ. Identification of a novel point mutation (S65T) in alpha-galactosidase A gene in Chinese patients with Fabry disease. Mutations in brief no. 169. Online. Hum Mutat. 1998; 11(4):328-30. PMID: 9554750.
      Citations:    
    102. Peng TI, Jou MJ, Sheu SS, Greenamyre JT. Visualization of NMDA receptor-induced mitochondrial calcium accumulation in striatal neurons. Exp Neurol. 1998 Jan; 149(1):1-12. PMID: 9454610.
      Citations:    
    103. Dhalla NS, Xu YJ, Sheu SS, Tappia PS, Panagia V. Phosphatidic acid: a potential signal transducer for cardiac hypertrophy. J Mol Cell Cardiol. 1997 Nov; 29(11):2865-71. PMID: 9405162.
      Citations:    
    104. Wang DX, Sheu SS, Sharma VK, Rubin L, Journet M, Kende AS, Abood LG. [3H]benzylpempidine, a new radioligand for probing a putative channel site on nicotinic cholinergic receptors. Life Sci. 1997; 60(15):1271-7. PMID: 9096244.
      Citations:    
    105. Sharma VK, Colecraft HM, Rubin LE, Sheu SS. Does mammalian heart contain only the M2 muscarinic receptor subtype? Life Sci. 1997; 60(13-14):1023-9. PMID: 9121343.
      Citations:    
    106. Jou MJ, Peng TI, Sheu SS. Histamine induces oscillations of mitochondrial free Ca2+ concentration in single cultured rat brain astrocytes. J Physiol. 1996 Dec 01; 497 ( Pt 2):299-308. PMID: 8961176.
      Citations:    
    107. Sharma VK, Colecraft HM, Wang DX, Levey AI, Grigorenko EV, Yeh HH, Sheu SS. Molecular and functional identification of m1 muscarinic acetylcholine receptors in rat ventricular myocytes. Circ Res. 1996 Jul; 79(1):86-93. PMID: 8925573.
      Citations:    
    108. Shu KH, Lu YS, Chang CH, Yang CR, Chan LP, Cheng CH, Sheu SS, Hsu JH, Lian JD. Transplant glomerulopathy--a clinicopathological study. Transplant Proc. 1996 Jun; 28(3):1527-8. PMID: 8658771.
      Citations:    
    109. Wu MJ, Shu KH, Chan LP, Lu YS, Cheng CH, Sheu SS, Hsu YH, Lian JD. Long-term clinical and morphological evaluation of primary membranoproliferative glomerulonephritis. Zhonghua Yi Xue Za Zhi (Taipei). 1996 Jan; 57(1):34-41. PMID: 8820034.
      Citations:    
    110. Sparagna GC, Gunter KK, Sheu SS, Gunter TE. Mitochondrial calcium uptake from physiological-type pulses of calcium. A description of the rapid uptake mode. J Biol Chem. 1995 Nov 17; 270(46):27510-5. PMID: 7499209.
      Citations:    
    111. Meyers MB, Pickel VM, Sheu SS, Sharma VK, Scotto KW, Fishman GI. Association of sorcin with the cardiac ryanodine receptor. J Biol Chem. 1995 Nov 03; 270(44):26411-8. PMID: 7592856.
      Citations:    
    112. Garcia MC, Sanchez JA, Sharma VK, Sheu SS. Extracellular heparin inhibits Ca2+ transients and contraction in mammalian cardiac myocytes. Pflugers Arch. 1995 Nov; 431(1):84-90. PMID: 8584421.
      Citations:    
    113. Shu KH, Lu YS, Chen CH, Sheu SS, Chan LP, Lian JD. Serum immunoglobulin E in primary IgA nephropathy. Clin Nephrol. 1995 Aug; 44(2):86-90. PMID: 8529314.
      Citations:    
    114. Arreola J, Dirksen RT, Perez-Cornejo P, Piech KM, Sheu SS. Autonomic modulation of action potential and tension in guinea pig papillary muscles. Eur J Pharmacol. 1994 Dec 27; 271(2-3):309-17. PMID: 7705431.
      Citations:    
    115. Sheu SS, Chan LP, Liao SC, Hsiao KJ, Shu KH, Lu YS, Cheng CH, Lian JD. Fabry's disease: clinical, pathologic and biochemical manifestations in two Chinese males. Zhonghua Yi Xue Za Zhi (Taipei). 1994 Nov; 54(5):368-72. PMID: 7834562.
      Citations:    
    116. Hsu JY, Shu KH, Chan LP, Lu YS, Cheng CH, Sheu SS, Lian JD. The clinicopathological spectrum of renal amyloidosis. Zhonghua Yi Xue Za Zhi (Taipei). 1994 Oct; 54(4):230-9. PMID: 7982133.
      Citations:    
    117. Wang DX, Lerner-Marmarosh N, Sheu SS, Sharma V, Jou MJ, Abood LG. Differences in ligand binding and phosphoinositide turnover between M1 muscarinic receptor gene transfected cells and mouse and rat brain membranes. Pharmacol Biochem Behav. 1994 Oct; 49(2):405-11. PMID: 7824557.
      Citations:    
    118. Sheu SS, Jou MJ. Mitochondrial free Ca2+ concentration in living cells. J Bioenerg Biomembr. 1994 Oct; 26(5):487-93. PMID: 7896764.
      Citations:    
    119. Gunter TE, Gunter KK, Sheu SS, Gavin CE. Mitochondrial calcium transport: physiological and pathological relevance. Am J Physiol. 1994 Aug; 267(2 Pt 1):C313-39. PMID: 8074170.
      Citations:    
    120. Sheu SS, Shu KH, Lu YS, Chan LP, Lian JD. Primary IgA nephropathy: a nine-year clinicopathologic study in the Veterans General Hospital-Taichung. Zhonghua Yi Xue Za Zhi (Taipei). 1993 Jun; 51(6):407-14. PMID: 8281486.
      Citations:    
    121. Borzak S, Reers M, Arruda J, Sharma VK, Sheu SS, Smith TW, Marsh JD. Na+ efflux mechanisms in ventricular myocytes: measurement of [Na+]i with Na(+)-binding benzofuran isophthalate. Am J Physiol. 1992 Sep; 263(3 Pt 2):H866-74. PMID: 1415613.
      Citations:    
    122. Jahnel U, Nawrath H, Shieh RC, Sharma VK, Williford DJ, Sheu SS. Modulation of cytosolic free calcium concentration by alpha 1-adrenoceptors in rat atrial cells. Naunyn Schmiedebergs Arch Pharmacol. 1992 Jul; 346(1):88-93. PMID: 1357558.
      Citations:    
    123. Christie A, Sharma VK, Sheu SS. Mechanism of extracellular ATP-induced increase of cytosolic Ca2+ concentration in isolated rat ventricular myocytes. J Physiol. 1992 Jan; 445:369-88. PMID: 1323668.
      Citations:    
    124. Arreola J, Dirksen RT, Shieh RC, Williford DJ, Sheu SS. Ca2+ current and Ca2+ transients under action potential clamp in guinea pig ventricular myocytes. Am J Physiol. 1991 Aug; 261(2 Pt 1):C393-7. PMID: 1651654.
      Citations:    
    125. Sheu SS, Sharma VK, Korth M, Moscucci A, Dirksen RT, Jou MJ. Receptor-mediated inotropic effect in heart. Role of sodium-calcium exchange. Ann N Y Acad Sci. 1991; 639:398-407. PMID: 1664703.
      Citations:    
    126. Vamvakas S, Sharma VK, Sheu SS, Anders MW. Perturbations of intracellular calcium distribution in kidney cells by nephrotoxic haloalkenyl cysteine S-conjugates. Mol Pharmacol. 1990 Oct; 38(4):455-61. PMID: 2233687.
      Citations:    
    127. Enyeart JJ, Dirksen RT, Sharma VK, Williford DJ, Sheu SS. Antipsychotic pimozide is a potent Ca2+ channel blocker in heart. Mol Pharmacol. 1990 May; 37(5):752-7. PMID: 2160063.
      Citations:    
    128. Dirksen RT, Sheu SS. Modulation of ventricular action potential by alpha 1-adrenoceptors and protein kinase C. Am J Physiol. 1990 Mar; 258(3 Pt 2):H907-11. PMID: 2156457.
      Citations:    
    129. Williford DJ, Sharma VK, Korth M, Sheu SS. Spatial heterogeneity of intracellular Ca2+ concentration in nonbeating guinea pig ventricular myocytes. Circ Res. 1990 Jan; 66(1):241-8. PMID: 2295141.
      Citations:    
    130. Sheu SS. Cytosolic sodium concentration regulates contractility of cardiac muscle. Basic Res Cardiol. 1989; 84 Suppl 1:35-45. PMID: 2818459.
      Citations:    
    131. Korth M, Sharma VK, Sheu SS. Stimulation of muscarinic receptors raises free intracellular Ca2+ concentration in rat ventricular myocytes. Circ Res. 1988 Jun; 62(6):1080-7. PMID: 3383357.
      Citations:    
    132. Zalups RK, Sheu SS. Effects of forskolin on intracellular sodium activity in resting and stimulated cardiac Purkinje fibers from sheep. J Mol Cell Cardiol. 1987 Sep; 19(9):887-96. PMID: 3430640.
      Citations:    
    133. Sheu SS, Sharma VK, Korth M. Voltage-dependent effects of isoproterenol on cytosolic Ca concentration in rat heart. Am J Physiol. 1987 Apr; 252(4 Pt 2):H697-703. PMID: 2436488.
      Citations:    
    134. Enyeart JJ, Sheu SS, Hinkle PM. Dihydropyridine modulators of voltage-sensitive Ca2+ channels specifically regulate prolactin production by GH4C1 pituitary tumor cells. J Biol Chem. 1987 Mar 05; 262(7):3154-9. PMID: 2434497.
      Citations:    
    135. Sheu SS, Sharma VK, Uglesity A. Na+-Ca2+ exchange contributes to increase of cytosolic Ca2+ concentration during depolarization in heart muscle. Am J Physiol. 1986 Apr; 250(4 Pt 1):C651-6. PMID: 3963177.
      Citations:    
    136. Sheu SS, Lederer WJ. Lidocaine's negative inotropic and antiarrhythmic actions. Dependence on shortening of action potential duration and reduction of intracellular sodium activity. Circ Res. 1985 Oct; 57(4):578-90. PMID: 2412723.
      Citations:    
    137. Sheu SS, Fozzard HA. Na/Ca exchange in the intact cardiac cell. J Gen Physiol. 1985 Mar; 85(3):476-8. PMID: 3989504.
      Citations:    
    138. Sheu SS, Sharma VK, Banerjee SP. Measurement of cytosolic free calcium concentration in isolated rat ventricular myocytes with quin 2. Circ Res. 1984 Dec; 55(6):830-4. PMID: 6499138.
      Citations:    
    139. Lado MG, Sheu SS, Fozzard HA. Effects of tonicity on tension and intracellular sodium and calcium activities in sheep heart. Circ Res. 1984 May; 54(5):576-85. PMID: 6723001.
      Citations:    
    140. Eisner DA, Lederer WJ, Sheu SS. The role of intracellular sodium activity in the anti-arrhythmic action of local anaesthetics in sheep Purkinje fibres. J Physiol. 1983 Jul; 340:239-57. PMID: 6310096.
      Citations:    
    141. Sheu SS, Fozzard HA. Transmembrane Na+ and Ca2+ electrochemical gradients in cardiac muscle and their relationship to force development. J Gen Physiol. 1982 Sep; 80(3):325-51. PMID: 6292328.
      Citations:    
    142. Cohen CJ, Fozzard HA, Sheu SS. Increase in intracellular sodium ion activity during stimulation in mammalian cardiac muscle. Circ Res. 1982 May; 50(5):651-62. PMID: 7074728.
      Citations:    
    143. Sheu SS, Korth M, Lathrop DA, Fozzard HA. Intra- and extracellular K+ and Na+ activities and resting membrane potential in sheep cardiac purkinje strands. Circ Res. 1980 Nov; 47(5):692-700. PMID: 7418129.
      Citations:    
    144. Fozzard HA, Sheu SS. Intracellular potassium and sodium activities of chick ventricular muscle during embryonic development. J Physiol. 1980 Sep; 306:579-86. PMID: 7463378.
      Citations:    
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