Thomas Jefferson University

Wayne Lau

TitleProfessor
InstitutionThomas Jefferson University
DepartmentEmergency Medicine
Address1020 Sansom St.
Philadelphia PA 19107
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Gan L, Zhao J, Yao P, Christopher TA, Lopez B, Lau WB, Koch W, Gao E, Ma X, Wang Y. Adipocyte-derived small extracellular vesicles exacerbate diabetic ischemic heart injury by promoting oxidative stress and mitochondrial-mediated cardiomyocyte apoptosis. Redox Biol. 2024 Dec 09; 79:103443. PMID: 39740363.
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    2. Du Y, Duan Y, Zhao J, Liu C, Zhang Z, Zhang J, Meng Z, Wang X, Lau WB, Xie D, Lopez BL, Christopher TA, Gao E, Koch WW, Liu H, Liu D, Ma XL, Gu G, Wang Y. Dysfunctional APPL1-Mediated Epigenetic Regulation in Diabetic Vascular Injury. Arterioscler Thromb Vasc Biol. 2023 Oct 05. PMID: 37795615.
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    3. Li QY, Lin XL, Li FQ, Cheng ZC, Tian JY, Zhao DH, Lau WB, Liu JH, Fan Q. A Chinese scoring system for predicting successful retrograde collateral traverse in patients with chronic?total coronary occlusion. BMC Cardiovasc Disord. 2023 07 29; 23(1):380. PMID: 37516887.
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    4. Meng Z, Liang B, Wu Y, Liu C, Wang H, Du Y, Gan L, Gao E, Lau WB, Christopher TA, Lopez BL, Koch WJ, Ma X, Zhao F, Wang Y, Zhao J. Hypoadiponectinemia-induced upregulation of microRNA449b downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury in diabetic mice. J Mol Cell Cardiol. 2023 Jul 10; 182:1-14. PMID: 37437402.
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    5. Meng Z, Zhang Z, Zhao J, Liu C, Yao P, Zhang L, Xie D, Lau WB, Tsukuda J, Christopher TA, Lopez B, Zhu D, Liu D, Zhang JR, Gao E, Ischiropoulos H, Koch W, Ma X, Wang Y. Nitrative Modification of Caveolin-3: A Novel Mechanism of Cardiac Insulin Resistance and a Potential Therapeutic Target Against Ischemic Heart Failure in Prediabetic Animals. Circulation. 2023 Mar 08. PMID: 36883479.
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    6. Zhang YQ, Zhang YW, Dai JL, Li C, Wang WQ, Zhang HF, Lau WB, Wang XM, Liu XG, Li R. Serum CTRP9 and high-molecular weight adiponectin are associated with ischemic stroke. BMC Neurol. 2022 Nov 15; 22(1):429. PMID: 36380279.
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    7. Zhu D, Zhang Z, Zhao J, Liu D, Gan L, Lau WB, Xie D, Meng Z, Yao P, Tsukuda J, Christopher TA, Lopez BL, Gao E, Koch WJ, Wang Y, Ma XL. Targeting Adiponectin Receptor 1 Phosphorylation Against Ischemic Heart Failure. Circ Res. 2022 May 25; 101161CIRCRESAHA121319976. PMID: 35611695.
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    8. Zhang H, Peng L, Wang Y, Zhao W, Lau WB, Wang Y, Li Y, Du Y, Li L, Huang Y, Nie S, Qin Y, Ma X, Wei Y. Extracellular vesicle-derived miR-144 as a novel mechanism for chronic intermittent hypoxia-induced endothelial dysfunction. Theranostics. 2022; 12(9):4237-4249. PMID: 35673562.
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    9. Zhang YQ, Fan S, Wang WQ, Lau WB, Dai JL, Zhang HF, Wang XM, Liu XG, Li R. Hyperlipidemic plasma molecules bind and inhibit adiponectin activity. J Diabetes Investig. 2022 Jan 12. PMID: 35023319.
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    10. Wang Y, Lau WB, Ma X. "Know Diabetes by Heart": role of adipocyte-cardiomyocyte communications. Med Rev (Berl). 2021 Oct; 1(1):14-17. PMID: 37724081.
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    11. Zhao J, Lin X, Sun H, Zhao D, Ma Q, Lau WB, Cheng Z, Li F, Liu J, Fan Q. lncRNA NONHSAT069381 and NONHSAT140844 Increase in Aging Human Blood, Regulating Cardiomyocyte Apoptosis. Oxid Med Cell Longev. 2021; 2021:9465300. PMID: 34336120.
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    12. Gao X, Du Y, Lau WB, Li Y, Zhu S, Ma XL. Atg16L1 as a Novel Biomarker and Autophagy Gene for Diabetic Retinopathy. J Diabetes Res. 2021; 2021:5398645. PMID: 33791389.
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    13. Liu D, Gu G, Gan L, Yan W, Zhang Z, Yao P, Zhu D, Lau WB, Xie D, Wu S, Meng Z, Tsukuda J, Christopher T, Lopez B, Zhao J, Gao E, Koch W, Ma XL, Wang Y. Identification of a CTRP9 C-Terminal polypeptide capable of enhancing bone-derived mesenchymal stem cell cardioprotection through promoting angiogenic exosome production. Redox Biol. 2021 May; 41:101929. PMID: 33714738.
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    14. Guo H, Ma K, Hao W, Jiao Y, Li P, Chen J, Xu C, Xu FJ, Lau WB, Du J, Ma XL, Li Y. mir15a/mir16-1 cluster and its novel targeting molecules negatively regulate cardiac hypertrophy. Clin Transl Med. 2020 Dec; 10(8):e242. PMID: 33377640.
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    15. Gan L, Xie D, Lau WB, Ma XL, Wang Y. Response by Gan et al to Letter Regarding Article, "Small Extracellular Microvesicles Mediated Pathological Communications Between Dysfunctional Adipocytes and Cardiomyocytes as a Novel Mechanism Exacerbating Ischemia/Reperfusion Injury in Diabetic Mice". Circulation. 2020 Aug 18; 142(7):e99-e100. PMID: 32804566.
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    16. Jia G, Meng Z, Liu C, Ma X, Gao J, Liu J, Guo R, Yan Z, Christopher T, Lopez B, Liu W, Dai H, Lau WB, Jiao X, Zhao J, Wang ZX, Cao J, Wang Y. Nicotine induces cardiac toxicity through blocking mitophagic clearance in young adult rat. Life Sci. 2020 Sep 15; 257:118084. PMID: 32663572.
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    17. Xu L, Gimple RC, Lau WB, Lau B, Fei F, Shen Q, Liao X, Li Y, Wang W, He Y, Feng M, Bu H, Wang W, Zhou S. THE PRESENT AND FUTURE OF THE MASS SPECTROMETRY-BASED INVESTIGATION OF THE EXOSOME LANDSCAPE. Mass Spectrom Rev. 2020 May 29. PMID: 32469100.
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    18. Liu J, Meng Z, Gan L, Guo R, Gao J, Liu C, Zhu D, Liu D, Zhang L, Zhang Z, Xie D, Jiao X, Lau WB, Lopez BL, Christopher TA, Ma X, Cao J, Wang Y. C1q/TNF-related protein 5 contributes to diabetic vascular endothelium dysfunction through promoting Nox-1 signaling. Redox Biol. 2020 Feb 24; 101476. PMID: 32122792.
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    19. Yan W, Lin C, Guo Y, Chen Y, Du Y, Lau WB, Xia Y, Zhang F, Su R, Gao E, Wang Y, Li C, Liu R, Ma XL, Tao L. N-Cadherin Overexpression Mobilizes the Protective Effects of Mesenchymal Stromal Cells Against Ischemic Heart Injury Through A ?-Catenin Dependent Manner. Circ Res. 2020 Feb 21. PMID: 32079489.
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    20. Zhang Y, Liu C, Liu J, Guo R, Yan Z, Liu W, Lau WB, Jiao X, Cao J, Xu K, Jia Y, Ma X, Wang Y. Implications of C1q/TNF-related protein superfamily in patients with coronary artery disease. Sci Rep. 2020 Jan 21; 10(1):878. PMID: 31965030.
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    21. Xie D, Zhao J, Guo R, Jiao L, Zhang Y, Lau WB, Lopez B, Christopher T, Gao E, Cao J, Ma X, Wang Y. Sevoflurane Pre-conditioning Ameliorates Diabetic Myocardial Ischemia/Reperfusion Injury Via Differential Regulation of p38 and ERK. Sci Rep. 2020 Jan 08; 10(1):23. PMID: 31913350.
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    22. Du Y, Wang X, Li LY, Hao W, Zhang H, Li Y, Qin Y, Nie S, Christopher T, Lopez B, Wang Y, Lau WB, Wei YX, Ma XL. miRNA-Mediated Suppression of a Cardioprotective Cardiokine as a Novel Mechanism Exacerbating Post-MI Remodeling by Sleep Breathing Disorders. Circ Res. 2019 Nov 07. PMID: 31694459.
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    23. Chen Z, Zhang P, Xu Y, Yan J, Liu Z, Lau WB, Lau B, Li Y, Zhao X, Wei Y, Zhou S. Surgical stress and cancer progression: the twisted tango. Mol Cancer. 2019 Sep 02; 18(1):132. PMID: 31477121.
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    24. Guo R, Gan L, Lau WB, Yan Z, Xie D, Gao E, Christopher TA, Lopez BL, Ma X, Wang Y. Withaferin A Prevents Myocardial Ischemia/Reperfusion Injury by Upregulating AMP-Activated Protein Kinase-Dependent B-Cell Lymphoma2 Signaling. Circ J. 2019 Jul 25; 83(8):1726-1736. PMID: 31217391.
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    25. Li J, Wilson J, Lau WB. A case report of case report pursuit by medical student. MedEdPublish (2016). 2019; 8:73. PMID: 38089374.
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    26. Du Y, Li X, Yu H, Yan L, Lau WB, Zhang S, Qin Y, Wang W, Ma X, Liu H, Fu M. Activation of T Lymphocytes as a Novel Mechanism in Beta1-Adrenergic Receptor Autoantibody-Induced Cardiac Remodeling. Cardiovasc Drugs Ther. 2019 Feb 12. PMID: 30747396.
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    27. Yan Z, Guo R, Gan L, Lau WB, Cao X, Zhao J, Ma X, Christopher TA, Lopez BL, Wang Y. Withaferin A inhibits apoptosis via activated Akt-mediated inhibition of oxidative stress. Life Sci. 2018 Oct 15; 211:91-101. PMID: 30213729.
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    28. Yang Q, Yang Y, Zhou N, Tang K, Lau WB, Lau B, Wang W, Xu L, Yang Z, Huang S, Wang X, Yi T, Zhao X, Wei Y, Wang H, Zhao L, Zhou S. Epigenetics in ovarian cancer: premise, properties, and perspectives. Mol Cancer. 2018 Jul 31; 17(1):109. PMID: 30064416.
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    29. Zhao D, Feng P, Sun Y, Qin Z, Zhang Z, Tan Y, Gao E, Lau WB, Ma X, Yang J, Yu S, Xu X, Yi D, Yi W. Cardiac-derived CTRP9 protects against myocardial ischemia/reperfusion injury via calreticulin-dependent inhibition of apoptosis. Cell Death Dis. 2018 Jun 20; 9(7):723. PMID: 29925877.
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    30. Chengsupanimit T, Sundaram B, Lau WB, Keith SW, Kane GC. Clinical characteristics of patients with pulmonary infarction - A retrospective review. Respir Med. 2018 Jun; 139:13-18. PMID: 29857996.
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    31. Zhao L, Huang S, Mei S, Yang Z, Xu L, Zhou N, Yang Q, Shen Q, Wang W, Le X, Lau WB, Lau B, Wang X, Yi T, Zhao X, Wei Y, Warner M, Gustafsson JÅ, Zhou S. Pharmacological activation of estrogen receptor beta augments innate immunity to suppress cancer metastasis. Proc Natl Acad Sci U S A. 2018 Apr 17; 115(16):E3673-E3681. PMID: 29592953.
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    32. Zhao L, Wang W, Huang S, Yang Z, Xu L, Yang Q, Zhou X, Wang J, Shen Q, Wang C, Le X, Feng M, Zhou N, Lau WB, Lau B, Yao S, Yi T, Wang X, Zhao X, Wei Y, Zhou S. The RNA binding protein SORBS2 suppresses metastatic colonization of ovarian cancer by stabilizing tumor-suppressive immunomodulatory transcripts. Genome Biol. 2018 Mar 16; 19(1):35. PMID: 29548303.
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    33. Jia L, Fan J, Cui W, Liu S, Li N, Lau WB, Ma X, Du J, Nie S, Wei Y. Endothelial Cell-Derived Microparticles from Patients with Obstructive Sleep Apnea Hypoxia Syndrome and Coronary Artery Disease Increase Aortic Endothelial Cell Dysfunction. Cell Physiol Biochem. 2017; 43(6):2562-2570. PMID: 29130961.
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    34. Yan W, Guo Y, Tao L, Lau WB, Gan L, Yan Z, Guo R, Gao E, Wong GW, Koch WL, Wang Y, Ma XL. C1q/Tumor Necrosis Factor-Related Protein-9 Regulates the Fate of Implanted Mesenchymal Stem Cells and Mobilizes Their Protective Effects Against Ischemic Heart Injury via Multiple Novel Signaling Pathways. Circulation. 2017 Nov 28; 136(22):2162-2177. PMID: 28978553.
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    35. Wang Y, Liang B, Lau WB, Du Y, Guo R, Yan Z, Gan L, Yan W, Zhao J, Gao E, Koch W, Ma XL. Restoring diabetes-induced autophagic flux arrest in ischemic/reperfused heart by ADIPOR (adiponectin receptor) activation involves both AMPK-dependent and AMPK-independent signaling. Autophagy. 2017; 13(11):1855-1869. PMID: 28825851.
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    36. Yan Z, Zhao J, Gan L, Zhang Y, Guo R, Cao X, Lau WB, Ma X, Wang Y. CTRP3 is a novel biomarker for diabetic retinopathy and inhibits HGHL-induced VCAM-1 expression in an AMPK-dependent manner. PLoS One. 2017; 12(6):e0178253. PMID: 28632765.
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    37. Lau WB, Ohashi K, Wang Y, Ogawa H, Murohara T, Ma XL, Ouchi N. Role of Adipokines in Cardiovascular Disease. Circ J. 2017 Jun 23; 81(7):920-928. PMID: 28603178.
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    38. Wang Y, Ma XL, Lau WB. Cardiovascular Adiponectin Resistance: The Critical Role of Adiponectin Receptor Modification. Trends Endocrinol Metab. 2017 Jul; 28(7):519-530. PMID: 28473178.
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    39. Wang H, Tao L, Ambrosio A, Yan W, Summer R, Lau WB, Wang Y, Ma X. T-cadherin deficiency increases vascular vulnerability in T2DM through impaired NO bioactivity. Cardiovasc Diabetol. 2017 Jan 19; 16(1):12. PMID: 28103886.
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    40. Zhao L, Ji G, Le X, Wang C, Xu L, Feng M, Zhang Y, Yang H, Xuan Y, Yang Y, Lei L, Yang Q, Lau WB, Lau B, Chen Y, Deng X, Yao S, Yi T, Zhao X, Wei Y, Zhou S. Long Noncoding RNA LINC00092 Acts in Cancer-Associated Fibroblasts to Drive Glycolysis and Progression of Ovarian Cancer. Cancer Res. 2017 Mar 15; 77(6):1369-1382. PMID: 28087599.
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    41. Wang K, Yuan Y, Liu X, Lau WB, Zuo L, Wang X, Ma L, Jiao K, Shang J, Wang W, Ma X, Liu H. Cardiac Specific Overexpression of Mitochondrial Omi/HtrA2 Induces Myocardial Apoptosis and Cardiac Dysfunction. Sci Rep. 2016 Dec 07; 6:37927. PMID: 27924873.
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    42. Yang Y, Zhao L, Lei L, Lau WB, Lau B, Yang Q, Le X, Yang H, Wang C, Luo Z, Xuan Y, Chen Y, Deng X, Xu L, Feng M, Yi T, Zhao X, Wei Y, Zhou S. LncRNAs: the bridge linking RNA and colorectal cancer. Oncotarget. 2016 Nov 24. PMID: 27888635.
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    43. Zhang F, Zhao S, Yan W, Xia Y, Chen X, Wang W, Zhang J, Gao C, Peng C, Yan F, Zhao H, Lian K, Lee Y, Zhang L, Lau WB, Ma X, Tao L. Branched Chain Amino Acids Cause Liver Injury in Obese/Diabetic Mice by Promoting Adipocyte Lipolysis and Inhibiting Hepatic Autophagy. EBioMedicine. 2016 Nov; 13:157-167. PMID: 27843095.
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    44. He Y, Zou L, Zhou Y, Hu H, Yao R, Jiang Y, Lau WB, Yuan T, Huang W, Zeng Z, Cao Y. Adiponectin ameliorates the apoptotic effects of paraquat on alveolar type ? cells via improvements in mitochondrial function. Mol Med Rep. 2016 Jul; 14(1):746-52. PMID: 27220901.
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    45. Luo Z, Wang Q, Lau WB, Lau B, Xu L, Zhao L, Yang H, Feng M, Xuan Y, Yang Y, Lei L, Wang C, Yi T, Zhao X, Wei Y, Zhou S. Tumor microenvironment: The culprit for ovarian cancer metastasis? Cancer Lett. 2016 Jul 28; 377(2):174-82. PMID: 27131957.
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    46. Zhao L, Yu C, Zhou S, Lau WB, Lau B, Luo Z, Lin Q, Yang H, Xuan Y, Yi T, Zhao X, Wei Y. Epigenetic repression of PDZ-LIM domain-containing protein 2 promotes ovarian cancer via NOS2-derived nitric oxide signaling. Oncotarget. 2016 Jan 12; 7(2):1408-20. PMID: 26593252.
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    47. Wang W, Lau WB, Wang Y, Ma X, Li R. Reduction of CTRP9, a novel anti-platelet adipokine, contributes to abnormal platelet activity in diabetic animals. Cardiovasc Diabetol. 2016; 15(1):6. PMID: 26754066.
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    48. Yang H, Lau WB, Lau B, Xuan Y, Zhou S, Zhao L, Luo Z, Lin Q, Ren N, Zhao X, Wei Y. A mass spectrometric insight into the origins of benign gynecological disorders. Mass Spectrom Rev. 2017 May; 36(3):450-470. PMID: 26633258.
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    49. Liu MD, Ning WD, Wang RC, Chen W, Yang Y, Lin Y, Hu DH, Lau WB, Qu Y. Low-Dose Versus Standard-Dose Tissue Plasminogen Activator in Acute Ischemic Stroke in Asian Populations: A Meta-Analysis. Medicine (Baltimore). 2015 Dec; 94(52):e2412. PMID: 26717400.
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    50. Liu GZ, Liang B, Lau WB, Wang Y, Zhao J, Li R, Wang X, Yuan Y, Lopez BL, Christopher TA, Xiao C, Ma XL, Wang Y. High glucose/High Lipids impair vascular adiponectin function via inhibition of caveolin-1/AdipoR1 signalsome formation. Free Radic Biol Med. 2015 Dec; 89:473-85. PMID: 26453924.
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    51. Yalamanchili S, Lau WB. A Curious Case of Cold Ludwig's Angina. J Emerg Med. 2015 Oct; 49(4):e121-2. PMID: 26149804.
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    52. Yang Y, Hu W, Jiang S, Wang B, Li Y, Fan C, Di S, Ma Z, Lau WB, Qu Y. The emerging role of adiponectin in cerebrovascular and neurodegenerative diseases. Biochim Biophys Acta. 2015 Sep; 1852(9):1887-94. PMID: 26118345.
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    53. Zhang Y, Zhao J, Li R, Lau WB, Yuan YX, Liang B, Li R, Gao EH, Koch WJ, Ma XL, Wang YJ. AdipoRon, the first orally active adiponectin receptor activator, attenuates postischemic myocardial apoptosis through both AMPK-mediated and AMPK-independent signalings. Am J Physiol Endocrinol Metab. 2015 Aug 1; 309(3):E275-82. PMID: 26037251.
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    54. Yao R, Cao Y, He YR, Lau WB, Zeng Z, Liang ZA. Adiponectin attenuates lung fibroblasts activation and pulmonary fibrosis induced by paraquat. PLoS One. 2015; 10(5):e0125169. PMID: 25945502.
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    55. Yang J, Li L, Shang JY, Cai L, Song L, Zhang SL, Li H, Li X, Lau WB, Ma XL, Liu HR. Angiotensin II type 1 receptor autoantibody as a novel regulator of aldosterone independent of preeclampsia. J Hypertens. 2015 May; 33(5):1046-56. PMID: 25693057.
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    56. Yuan Y, Lau WB, Su H, Sun Y, Yi W, Du Y, Christopher T, Lopez B, Wang Y, Ma XL. C1q-TNF-related protein-9, a novel cardioprotetcive cardiokine, requires proteolytic cleavage to generate a biologically active globular domain isoform. Am J Physiol Endocrinol Metab. 2015 May 15; 308(10):E891-8. PMID: 25783894.
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    57. Wang Y, Gao E, Lau WB, Wang Y, Liu G, Li JJ, Wang X, Yuan Y, Koch WJ, Ma XL. G-protein-coupled receptor kinase 2-mediated desensitization of adiponectin receptor 1 in failing heart. Circulation. 2015 Apr 21; 131(16):1392-404. PMID: 25696921.
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    58. Xuan Y, Yang H, Zhao L, Lau WB, Lau B, Ren N, Hu Y, Yi T, Zhao X, Zhou S, Wei Y. MicroRNAs in colorectal cancer: Small molecules with big functions. Cancer Lett. 2015 May 1; 360(2):89-105. PMID: 25524553.
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    59. Yao R, Zhou Y, He Y, Jiang Y, Liu P, Ye L, Zheng Z, Lau WB, Cao Y, Zeng Z. Adiponectin protects against paraquat-induced lung injury by attenuating oxidative/nitrative stress. Exp Ther Med. 2015 Jan; 9(1):131-136. PMID: 25452788.
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    60. He Q, Pu J, Yuan A, Lau WB, Gao E, Koch WJ, Ma XL, He B. Activation of Liver-X-Receptor a But Not Liver-X-Receptor ß Protects Against Myocardial Ischemia/Reperfusion Injury. Circ Heart Fail. 2014 Nov; 7(6):1032-41. PMID: 25277999.
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    61. Yu Q, Zhou N, Nan Y, Zhang L, Li Y, Hao X, Xiong L, Lau WB, Ma XL, Wang H, Gao F. Effective glycaemic control critically determines insulin cardioprotection against ischaemia/reperfusion injury in anaesthetized dogs. Cardiovasc Res. 2014 Jul 15; 103(2):238-47. PMID: 24845581.
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    62. Liu S, Nie H, Huang W, Liu X, Luo L, Lau WB, Cao Y. Characteristics of patients who leave the emergency department without being seen: The first report in China. Emerg Med Australas. 2014 Jun; 26(3):243-8. PMID: 24712718.
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    63. Fan Q, Chen L, Cheng S, Li F, Lau WB, Wang le F, Liu JH. Aging Aggravates Nitrate-Mediated ROS/RNS Changes. Oxid Med Cell Longev. 2014; 2014:376515. PMID: 24790702.
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    64. Wei W, Lau WB, Chen Y, Hu X, Nie H. Severe lactic acidosis and acute hepatic and renal insufficiency due to fenaminosulf poisoning. Clin Toxicol (Phila). 2014 Apr; 52(4):446-7. PMID: 24649893.
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    65. Zhang M, Yang M, Liu LP, Lau WB, Gao H, Xin MK, Su LX, Wang J, Cheng SJ, Fan Q, Liu JH. BMP-2 Overexpression Augments Vascular Smooth Muscle Cell Motility by Upregulating Myosin Va via Erk Signaling. Oxid Med Cell Longev. 2014; 2014:294150. PMID: 24790701.
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    66. Yang X, Wang F, Lau WB, Zhang S, Zhang S, Liu H, Ma XL. Autoantibodies Isolated from Preeclamptic Patients Induce Endothelial Dysfunction via Interaction with the Angiotensin II AT1 Receptor. Cardiovasc Toxicol. 2014 Mar; 14(1):21-9. PMID: 24122090.
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    67. Wang Y, Wang X, Lau WB, Yuan Y, Booth D, Li JJ, Scalia R, Preston K, Gao E, Koch W, Ma XL. Adiponectin Inhibits Tumor Necrosis Factor-a-Induced Vascular Inflammatory Response via Caveolin-Mediated Ceramidase Recruitment and Activation. Circ Res. 2014 Feb 28; 114(5):792-805. PMID: 24397980.
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    68. Zhang Y, Wang XL, Zhao J, Wang YJ, Lau WB, Yuan YX, Gao EH, Koch WJ, Ma XL. Adiponectin inhibits oxidative/nitrative stress during myocardial ischemia and reperfusion via PKA signaling. Am J Physiol Endocrinol Metab. 2013 Dec; 305(12):E1436-43. PMID: 24129398.
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    69. Fan Q, Huang ZM, Boucher M, Shang X, Zuo L, Brinks H, Lau WB, Zhang J, Chuprun JK, Gao E. Inhibition of Fas-associated death domain-containing protein (FADD) protects against myocardial ischemia/reperfusion injury in a heart failure mouse model. PLoS One. 2013; 8(9):e73537. PMID: 24058479.
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    70. Sun Y, Yi W, Yuan Y, Lau WB, Yi D, Wang X, Wang Y, Su H, Wang X, Gao E, Koch WJ, Ma XL. C1q/Tumor Necrosis Factor-Related Protein-9, a Novel Adipocyte-Derived Cytokine, Attenuates Adverse Remodeling in the Ischemic Mouse Heart via Protein Kinase A Activation. Circulation. 2013 Sep 10; 128(26 Suppl 1):S113-20. PMID: 24030394.
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    71. Zhao J, Wang F, Zhang Y, Jiao L, Lau WB, Wang L, Liu B, Gao E, Koch WJ, Ma XL, Wang Y. Sevoflurane Preconditioning Attenuates Myocardial Ischemia/Reperfusion Injury via Caveolin-3-Dependent Cyclooxygenase-2 Inhibition. Circulation. 2013 Sep 10; 128(26 Suppl 1):S121-9. PMID: 24030395.
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    72. Wang Y, Li X, Wang X, Lau W, Wang Y, Xing Y, Zhang X, Ma X, Gao F. Ginsenoside Rd attenuates myocardial ischemia/reperfusion injury via Akt/GSK-3ß signaling and inhibition of the mitochondria-dependent apoptotic pathway. PLoS One. 2013; 8(8):e70956. PMID: 23976968.
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    73. Li H, Bian Y, Zhang N, Guo J, Wang C, Lau WB, Xiao C. Intermedin protects against myocardial ischemia-reperfusion injury in diabetic rats. Cardiovasc Diabetol. 2013; 12:91. PMID: 23777472.
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    74. Zhang Y, Zhao J, Lau WB, Jiao LY, Liu B, Yuan Y, Wang X, Gao E, Koch WJ, Ma XL, Wang Y. Tumor Necrosis Factor-a and Lymphotoxin-a Mediate Myocardial Ischemic Injury via TNF Receptor 1, but Are Cardioprotective When Activating TNF Receptor 2. PLoS One. 2013; 8(5):e60227. PMID: 23704873.
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    75. Bai K, Wang K, Li X, Wang J, Zhang J, Song L, Wang J, Zhang S, Lau WB, Ma X, Liu H. Autoantibody against angiotensin AT1 receptor from preeclamptic patients enhances collagen-induced human platelet aggregation. Acta Biochim Biophys Sin (Shanghai). 2013 Sep; 45(9):749-55. PMID: 23681235.
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    76. Wang W, Xing W, Zhang H, Ding M, Shang L, Lau WB, Wang X, Li R. Reduced high-molecular-weight adiponectin is an independent risk factor for cardiovascular lesions in hypercholesterolaemic patients. Clin Endocrinol (Oxf). 2013 Apr; 78(4):539-44. PMID: 22612653.
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    77. Lei S, Li H, Xu J, Liu Y, Gao X, Wang J, Ng KF, Lau WB, Ma XL, Rodrigues B, Irwin MG, Xia Z. Hyperglycemia-Induced Protein Kinase C ß2 Activation Induces Diastolic Cardiac Dysfunction in Diabetic Rats by Impairing Caveolin-3 Expression and Akt/eNOS Signaling. Diabetes. 2013 Jul; 62(7):2318-28. PMID: 23474486.
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    78. Yan W, Zhang H, Liu P, Wang H, Liu J, Gao C, Liu Y, Lian K, Yang L, Sun L, Guo Y, Zhang L, Dong L, Lau WB, Gao E, Gao F, Xiong L, Wang H, Qu Y, Tao L. Impaired mitochondrial biogenesis due to dysfunctional adiponectin-AMPK-PGC-1a signaling contributing to increased vulnerability in diabetic heart. Basic Res Cardiol. 2013 May; 108(3):329. PMID: 23460046.
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    79. Wang Y, Zhao J, Zhang Y, Lau WB, Jiao LY, Liu B, Yuan Y, Wang X, Tao L, Gao E, Koch WJ, Ma XL. Differential regulation of TNF receptor 1 and receptor 2 in adiponectin expression following myocardial ischemia. Int J Cardiol. 2013 Oct 3; 168(3):2201-6. PMID: 23465561.
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    80. Gilmore T, O'Malley GF, Lau WB, Vann DR, Bromberg A, Martin A, Gibbons A, Rimmer E. A Comparison of the Prevalence of Lead-Contaminated Imported Chinese Ceramic Dinnerware Purchased Inside Versus Outside Philadelphia's Chinatown. J Med Toxicol. 2013 Mar; 9(1):16-20. PMID: 22492164.
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    81. Lau WB, Zhang Y, Zhao J, Liu B, Wang X, Yuan Y, Christopher TA, Lopez B, Gao E, Koch WJ, Ma XL, Wang Y. Lymphotoxin-a is a novel adiponectin expression suppressor following myocardial ischemia/reperfusion. Am J Physiol Endocrinol Metab. 2013 Mar; 304(6):E661-7. PMID: 23360826.
      Citations:    
    82. Pei H, Qu Y, Lu X, Yu Q, Lian K, Liu P, Yan W, Liu J, Ma Y, Liu Y, Li C, Li W, Lau WB, Zhang H, Tao L. Cardiac-derived adiponectin induced by long-term insulin treatment ameliorates myocardial ischemia/reperfusion injury in type 1 diabetic mice via AMPK signaling. Basic Res Cardiol. 2013 Jan; 108(1):322. PMID: 23262803.
      Citations:    
    83. Su H, Yuan Y, Wang XM, Lau WB, Wang Y, Wang X, Gao E, Koch WJ, Ma XL. Inhibition of CTRP9, a novel and cardiac-abundantly expressed cell survival molecule, by TNFa-initiated oxidative signaling contributes to exacerbated cardiac injury in diabetic mice. Basic Res Cardiol. 2013 Jan; 108(1):315. PMID: 23212557.
      Citations:    
    84. Chao XD, Ma YH, Luo P, Cao L, Lau WB, Zhao BC, Han F, Liu W, Ning WD, Su N, Zhang L, Zhu J, Fei Z, Qu Y. Up-regulation of Heme oxygenase-1 attenuates brain damage after cerebral ischemia via simultaneous inhibition of superoxide production and preservation of NO bioavailability. Exp Neurol. 2013 Jan; 239:163-9. PMID: 23059458.
      Citations:    
    85. Yi W, Sun Y, Yuan Y, Lau WB, Zheng Q, Wang X, Wang Y, Shang X, Gao E, Koch WJ, Ma XL. C1q/tumor necrosis factor-related protein-3, a newly identified adipokine, is a novel antiapoptotic, proangiogenic, and cardioprotective molecule in the ischemic mouse heart. Circulation. 2012 Jun 26; 125(25):3159-69. PMID: 22653084.
      Citations:    
    86. Fan Q, Chen M, Fang X, Lau WB, Xue L, Zhao L, Zhang H, Liang YH, Bai X, Niu HY, Ye J, Chen Q, Yang X, Liu M. Aging might augment reactive oxygen species (ROS) formation and affect reactive nitrogen species (RNS) level after myocardial ischemia/reperfusion in both humans and rats. Age (Dordr). 2013 Aug; 35(4):1017-26. PMID: 22580631.
      Citations:    
    87. Zhang S, Zhang X, Yang L, Yan Z, Yan L, Tian J, Li X, Song L, Wang L, Yang X, Zheng R, Lau WB, Ma X, Liu H. Increased susceptibility to metabolic syndrome in adult offspring of angiotensin type 1 receptor autoantibody-positive rats. Antioxid Redox Signal. 2012 Sep 1; 17(5):733-43. PMID: 22304458.
      Citations:    
    88. Wang Y, Wang X, Jasmin JF, Lau WB, Li R, Yuan Y, Yi W, Chuprun K, Lisanti MP, Koch WJ, Gao E, Ma XL. Essential role of caveolin-3 in adiponectin signalsome formation and adiponectin cardioprotection. Arterioscler Thromb Vasc Biol. 2012 Apr; 32(4):934-42. PMID: 22328772.
      Citations:    
    89. Pu J, Yuan A, Shan P, Gao E, Wang X, Wang Y, Lau WB, Koch W, Ma XL, He B. Cardiomyocyte-expressed farnesoid-X-receptor is a novel apoptosis mediator and contributes to myocardial ischaemia/reperfusion injury. Eur Heart J. 2013 Jun; 34(24):1834-45. PMID: 22307460.
      Citations:    
    90. Hennessey A, Setyono DA, Lau WB, Fields JM. A patient with a large pulmonary saddle embolus eluding both clinical gestalt and validated decision rules. Ann Emerg Med. 2012 Jun; 59(6):521-3. PMID: 22153968.
      Citations:    
    91. Su H, Lau WB, Ma XL. Hypoadiponectinaemia in diabetes mellitus type 2: molecular mechanisms and clinical significance. Clin Exp Pharmacol Physiol. 2011 Dec; 38(12):897-904. PMID: 21916932.
      Citations:    
    92. Zheng Q, Yuan Y, Yi W, Lau WB, Wang Y, Wang X, Sun Y, Lopez BL, Christopher TA, Peterson JM, Wong GW, Yu S, Yi D, Ma XL. C1q/TNF-related proteins, a family of novel adipokines, induce vascular relaxation through the adiponectin receptor-1/AMPK/eNOS/nitric oxide signaling pathway. Arterioscler Thromb Vasc Biol. 2011 Nov; 31(11):2616-23. PMID: 21836066.
      Citations:    
    93. Liu S, Yin T, Wei X, Yi W, Qu Y, Liu Y, Wang R, Lian K, Xia C, Pei H, Sun L, Ma Y, Lau WB, Gao E, Koch WJ, Wang H, Tao L. Downregulation of adiponectin induced by tumor necrosis factor a is involved in the aggravation of posttraumatic myocardial ischemia/reperfusion injury. Crit Care Med. 2011 Aug; 39(8):1935-43. PMID: 21499085.
      Citations:    
    94. Li S, Zhu J, Zhang W, Chen Y, Zhang K, Popescu LM, Ma X, Lau WB, Rong R, Yu X, Wang B, Li Y, Xiao C, Zhang M, Wang S, Yu L, Chen AF, Yang X, Cai J. Signature microRNA expression profile of essential hypertension and its novel link to human cytomegalovirus infection. Circulation. 2011 Jul 12; 124(2):175-84. PMID: 21690488.
      Citations:    
    95. Liang H, Hou H, Yi W, Yang G, Gu C, Lau WB, Gao E, Ma X, Lu Z, Wei X, Pei J, Yi D. Increased expression of pigment epithelium-derived factor in aged mesenchymal stem cells impairs their therapeutic efficacy for attenuating myocardial infarction injury. Eur Heart J. 2013 Jun; 34(22):1681-90. PMID: 21606086.
      Citations:    
    96. Ma Y, Liu Y, Liu S, Qu Y, Wang R, Xia C, Pei H, Lian K, Yin T, Lu X, Sun L, Yang L, Cao Y, Lau WB, Gao E, Wang H, Tao L. Dynamic alteration of adiponectin/adiponectin receptor expression and its impact on myocardial ischemia/reperfusion in type 1 diabetic mice. Am J Physiol Endocrinol Metab. 2011 Sep; 301(3):E447-55. PMID: 21586697.
      Citations:    
    97. Lau WB, Tao L, Wang Y, Li R, Ma XL. Systemic adiponectin malfunction as a risk factor for cardiovascular disease. Antioxid Redox Signal. 2011 Oct 1; 15(7):1863-73. PMID: 21091079.
      Citations:    
    98. Yi W, Sun Y, Gao E, Wei X, Lau WB, Zheng Q, Wang Y, Yuan Y, Wang X, Tao L, Li R, Koch W, Ma XL. Reduced cardioprotective action of adiponectin in high-fat diet-induced type II diabetic mice and its underlying mechanisms. Antioxid Redox Signal. 2011 Oct 1; 15(7):1779-88. PMID: 21091073.
      Citations:    
    99. Wang LL, Zhao JL, Lau WB, Zhang YQ, Qiao ZD, Wang YJ. Estradiol pretreatment attenuated nicotine-induced endothelial cell apoptosis via estradiol functional membrane receptor. Int Immunopharmacol. 2011 Jun; 11(6):675-82. PMID: 21262190.
      Citations:    
    100. Li R, Lau WB, Ma XL. Adiponectin resistance and vascular dysfunction in the hyperlipidemic state. Acta Pharmacol Sin. 2010 Oct; 31(10):1258-66. PMID: 20802503.
      Citations:    
    101. Yin T, Hou R, Liu S, Lau WB, Wang H, Tao L. Nitrative inactivation of thioredoxin-1 increases vulnerability of diabetic hearts to ischemia/reperfusion injury. J Mol Cell Cardiol. 2010 Sep; 49(3):354-61. PMID: 20497906.
      Citations:    
    102. Wang XL, Lau WB, Yuan YX, Wang YJ, Yi W, Christopher TA, Lopez BL, Liu HR, Ma XL. Methylglyoxal increases cardiomyocyte ischemia-reperfusion injury via glycative inhibition of thioredoxin activity. Am J Physiol Endocrinol Metab. 2010 Aug; 299(2):E207-14. PMID: 20460580.
      Citations:    
    103. Wei X, Yi W, Chen W, Ma X, Lau WB, Wang H, Yi D. Clinical outcomes with the epicholorohydrin-modified porcine aortic heart valve: a 15-year follow-up. Ann Thorac Surg. 2010 May; 89(5):1417-24. PMID: 20417754.
      Citations:    
    104. Yuan Y, Jiao X, Lau WB, Wang Y, Christopher TA, Lopez BL, Ramachandrarao SP, Tao L, Ma XL. Thioredoxin glycation: A novel posttranslational modification that inhibits its antioxidant and organ protective actions. Free Radic Biol Med. 2010 Aug 1; 49(3):332-8. PMID: 20416371.
      Citations:    
    105. Li R, Xu M, Wang X, Wang Y, Lau WB, Yuan Y, Yi W, Wei X, Lopez BL, Christopher TA, Wang XM, Ma XL. Reduced vascular responsiveness to adiponectin in hyperlipidemic rats--mechanisms and significance. J Mol Cell Cardiol. 2010 Sep; 49(3):508-15. PMID: 20303976.
      Citations:    
    106. Chen G, Lai W, Liu F, Mao Q, Tu F, Wen J, Xiao H, Zhang JC, Zhu T, Chen B, Hu ZY, Li RM, Liang Z, Nie H, Yan H, Yang BX, Du Q, Huang WX, Jiang YW, Kwan AS, Song L, Wu CM, Xiang T, Xu HW, Lau WB, Song HB, Wen CB, Yao ZH, Zhang L, Zeng J, Dai YE, Lopez BL, Zheng JQ, Zhou J, Christopher TA, Ma XL, Yu H, Xu LL, Guo Q, Song ZP, Volinn E, Kryger K, Cao Y, Ge H, Liu H, Luo CZ, Tao W, Zuo YX, Liu J. The dragon strikes: lessons from the Wenchuan earthquake. Anesth Analg. 2010 Mar 1; 110(3):908-15. PMID: 20185667.
      Citations:    
    107. Nie H, Tang SY, Lau WB, Zhang JC, Jiang YW, Lopez BL, Ma XL, Cao Y, Christopher TA. Triage during the week of the Sichuan earthquake: a review of utilized patient triage, care, and disposition procedures. Injury. 2011 May; 42(5):515-20. PMID: 20153857.
      Citations:    
    108. Wang Y, Lau WB, Gao E, Tao L, Yuan Y, Li R, Wang X, Koch WJ, Ma XL. Cardiomyocyte-derived adiponectin is biologically active in protecting against myocardial ischemia-reperfusion injury. Am J Physiol Endocrinol Metab. 2010 Mar; 298(3):E663-70. PMID: 20028965.
      Citations:    
    109. Dai JY, Dou KF, Wang CH, Zhao P, Lau WB, Tao L, Wu YM, Tang J, Jiang JL, Chen ZN. The interaction of HAb18G/CD147 with integrin alpha6beta1 and its implications for the invasion potential of human hepatoma cells. BMC Cancer. 2009; 9:337. PMID: 19775453.
      Citations:    
    110. Wang Y, Tao L, Yuan Y, Lau WB, Li R, Lopez BL, Christopher TA, Tian R, Ma XL. Cardioprotective effect of adiponectin is partially mediated by its AMPK-independent antinitrative action. Am J Physiol Endocrinol Metab. 2009 Aug; 297(2):E384-91. PMID: 19470831.
      Citations:    
    111. Luan R, Liu S, Yin T, Lau WB, Wang Q, Guo W, Wang H, Tao L. High glucose sensitizes adult cardiomyocytes to ischaemia/reperfusion injury through nitrative thioredoxin inactivation. Cardiovasc Res. 2009 Jul 15; 83(2):294-302. PMID: 19276128.
      Citations:    
    112. Wang Y, Gao E, Tao L, Lau WB, Yuan Y, Goldstein BJ, Lopez BL, Christopher TA, Tian R, Koch W, Ma XL. AMP-activated protein kinase deficiency enhances myocardial ischemia/reperfusion injury but has minimal effect on the antioxidant/antinitrative protection of adiponectin. Circulation. 2009 Feb 17; 119(6):835-44. PMID: 19188503.
      Citations:    
    113. Jiao XY, Gao E, Yuan Y, Wang Y, Lau WB, Koch W, Ma XL, Tao L. INO-4885 [5,10,15,20-tetra[N-(benzyl-4'-carboxylate)-2-pyridinium]-21H,23H-porphine iron(III) chloride], a peroxynitrite decomposition catalyst, protects the heart against reperfusion injury in mice. J Pharmacol Exp Ther. 2009 Mar; 328(3):777-84. PMID: 19033557.
      Citations:    
    114. Liu HR, Tao L, Gao E, Qu Y, Lau WB, Lopez BL, Christopher TA, Koch W, Yue TL, Ma XL. Rosiglitazone inhibits hypercholesterolaemia-induced myeloperoxidase upregulation--a novel mechanism for the cardioprotective effects of PPAR agonists. Cardiovasc Res. 2009 Feb 1; 81(2):344-52. PMID: 19010810.
      Citations:    
    115. Cao Y, Tao L, Yuan Y, Jiao X, Lau WB, Wang Y, Christopher T, Lopez B, Chan L, Goldstein B, Ma XL. Endothelial dysfunction in adiponectin deficiency and its mechanisms involved. J Mol Cell Cardiol. 2009 Mar; 46(3):413-9. PMID: 19027750.
      Citations:    
    116. Tao L, Jiao X, Gao E, Lau WB, Yuan Y, Lopez B, Christopher T, RamachandraRao SP, Williams W, Southan G, Sharma K, Koch W, Ma XL. Nitrative inactivation of thioredoxin-1 and its role in postischemic myocardial apoptosis. Circulation. 2006 Sep 26; 114(13):1395-402. PMID: 16966583.
      Citations:    
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