Angelo Lepore

TitleAssoc Professor
InstitutionThomas Jefferson University
DepartmentDepartment of Neurosciences
Address900 Walnut Street
Philadelphia PA 19107
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    F32NS059155     (LEPORE, ANGELO C.)Mar 1, 2008 - Feb 28, 2011
    NIH
    Transplantation of glial precursors: Astrocyte replacement in ALS
    Role: Principal Investigator

    R01NS079702     (LEPORE, ANGELO C)Mar 1, 2013 - Feb 28, 2023
    NIH
    Exploring mechanisms of axon growth and circuit connectivity for promoting respiratory function recovery following cervical spinal cord injury
    Role: Principal Investigator

    R56NS096028     (LEPORE, ANGELO C.)Sep 25, 2017 - Aug 31, 2019
    NIH
    Targeting chronic neuropathic pain after SCI using human iPS cell transplantation
    Role: Principal Investigator

    R01NS110385     (LEPORE, ANGELO C.)Sep 1, 2018 - Aug 31, 2023
    NIH
    Exploring the EphB2-NMDA receptor interaction in spinal cord injury-induced neuropathic pain
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cheng L, Sami A, Ghosh B, Urban MW, Heinsinger NM, Liang SS, Smith GM, Wright MC, Li S, Lepore AC. LAR inhibitory peptide promotes recovery of diaphragm function and multiple forms of respiratory neural circuit plasticity after cervical spinal cord injury. Neurobiol Dis. 2021 Jan; 147:105153. PMID: 33127470.
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    2. Martins-Macedo J, Lepore AC, Domingues HS, Salgado AJ, Gomes ED, Pinto L. Glial restricted precursor cells in central nervous system disorders: Current applications and future perspectives. Glia. 2021 Mar; 69(3):513-531. PMID: 33052610.
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    3. Heinsinger NM, Spagnuolo G, Allahyari RV, Galer S, Fox T, Jaffe DA, Thomas SJ, Iacovitti L, Lepore AC. Facial grimace testing as an assay of neuropathic pain-related behavior in a mouse model of cervical spinal cord injury. Exp Neurol. 2020 Dec; 334:113468. PMID: 32966805.
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    4. Gomes ED, Ghosh B, Lima R, Goulão M, Moreira-Gomes T, Martins-Macedo J, Urban MW, Wright MC, Gimble JM, Sousa N, Silva NA, Lepore AC, Salgado AJ. Combination of a Gellan Gum-Based Hydrogel With Cell Therapy for the Treatment of Cervical Spinal Cord Injury. Front Bioeng Biotechnol. 2020; 8:984. PMID: 32984278.
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    5. Bisetto S, Wright MC, Nowak RA, Lepore AC, Khurana TS, Loro E, Philp NJ. New Insights into the Lactate Shuttle: Role of MCT4 in the Modulation of the Exercise Capacity. iScience. 2019 Dec 20; 22:507-518. PMID: 31837519.
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    6. Charsar BA, Brinton MA, Locke K, Chen AY, Ghosh B, Urban MW, Komaravolu S, Krishnamurthy K, Smit R, Pasinelli P, Wright MC, Smith GM, Lepore AC. AAV2-BDNF promotes respiratory axon plasticity and recovery of diaphragm function following spinal cord injury. FASEB J. 2019 Oct 02; fj201901730R. PMID: 31577916.
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    7. Urban MW, Ghosh B, Block CG, Strojny LR, Charsar BA, Goulão M, Komaravolu SS, Smith GM, Wright MC, Li S, Lepore AC. Long-distance axon regeneration promotes recovery of diaphragmatic respiratory function after spinal cord injury. eNeuro. 2019 Aug 19. PMID: 31427403.
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    8. Urban MW, Ghosh B, Block CG, Charsar BA, Smith GM, Wright MC, Li S, Lepore AC. PTPs inhibitory peptide promotes recovery of diaphragm function and sprouting of bulbospinal respiratory axons following cervical spinal cord injury. J Neurotrauma. 2019 Aug 08. PMID: 31392919.
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    9. Ghosh B, Nong J, Wang Z, Urban MW, Heinsinger NM, Trovillion VA, Wright MC, Lepore AC, Zhong Y. A hydrogel engineered to deliver minocycline locally to the injured cervical spinal cord protects respiratory neural circuitry and preserves diaphragm function. Neurobiol Dis. 2019 Apr 25; 127:591-604. PMID: 31028873.
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    10. Goulão M, Ghosh B, Urban MW, Sahu M, Mercogliano C, Charsar BA, Komaravolu S, Block CG, Smith GM, Wright MC, Lepore AC. Astrocyte progenitor transplantation promotes regeneration of bulbospinal respiratory axons, recovery of diaphragm function, and a reduced macrophage response following cervical spinal cord injury. Glia. 2019 03; 67(3):452-466. PMID: 30548313.
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    11. Ghosh B, Wang Z, Nong J, Urban MW, Zhang Z, Trovillion VA, Wright MC, Zhong Y, Lepore AC. Local BDNF Delivery to the Injured Cervical Spinal Cord using an Engineered Hydrogel Enhances Diaphragmatic Respiratory Function. J Neurosci. 2018 Jun 27; 38(26):5982-5995. PMID: 29891731.
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    12. Muqeem T, Ghosh B, Pinto V, Lepore AC, Covarrubias M. Regulation of nociceptive glutamatergic signaling by presynaptic Kv3.4 channels in the rat spinal dorsal horn. J Neurosci. 2018 Mar 14. PMID: 29540546.
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    13. Falnikar A, Stratton J, Lin R, Andrews CE, Tyburski A, Trovillion VA, Gottschalk C, Ghosh B, Iacovitti L, Elliott MB, Lepore AC. Differential response in novel stem cell niches of the brain following cervical spinal cord injury and traumatic brain injury. J Neurotrauma. 2018 Feb 22. PMID: 29471717.
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    14. Urban MW, Ghosh B, Strojny LR, Block CG, Blazejewski SM, Wright MC, Smith GM, Lepore AC. Cell-type specific expression of constitutively-active Rheb promotes regeneration of bulbospinal respiratory axons following cervical SCI. Exp Neurol. 2018 May; 303:108-119. PMID: 29453976.
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    15. Gomes ED, Mendes SS, Assunção-Silva RC, Teixeira FG, Pires AO, Anjo SI, Manadas B, Leite-Almeida H, Gimble JM, Sousa N, Lepore AC, Silva NA, Salgado AJ. Cotransplantation of Adipose Tissue-Derived Stromal Cells and Olfactory Ensheathing Cells for Spinal Cord Injury Repair. Stem Cells. 2018 Jan 20. PMID: 29352743.
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    16. Zemel BM, Muqeem T, Brown EV, Goulão M, Urban MW, Tymanskyj SR, Lepore AC, Covarrubias M. Calcineurin dysregulation underlies spinal cord injury-induced K+ channel dysfunction in DRG neurons. J Neurosci. 2017 Jul 27. PMID: 28751455.
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    17. Rosenblum LT, Shamamandri-Markandaiah S, Ghosh B, Foran E, Lepore AC, Pasinelli P, Trotti D. Mutation of the caspase-3 cleavage site in the astroglial glutamate transporter EAAT2 delays disease progression and extends lifespan in the SOD1-G93A mouse model of ALS. Exp Neurol. 2017 Jun; 292:145-153. PMID: 28342750.
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    18. Tymanskyj SR, Yang B, Falnikar A, Lepore AC, Ma L. MAP7 Regulates Axon Collateral Branch Development in Dorsal Root Ganglion Neurons. J Neurosci. 2017 Feb 08; 37(6):1648-1661. PMID: 28069923.
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    19. Lane MA, Lepore AC, Fischer I. Improving the therapeutic efficacy of neural progenitor cell transplantation following spinal cord injury. Expert Rev Neurother. 2016 Dec 07. PMID: 27927055.
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    20. Charsar BA, Urban MW, Lepore AC. Harnessing the power of cell transplantation to target respiratory dysfunction following spinal cord injury. Exp Neurol. 2017 Jan; 287(Pt 2):268-275. PMID: 27531634.
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    21. Hazra A, Corbett BF, You JC, Aschmies S, Zhao L, Li K, Lepore AC, Marsh ED, Chin J. Corticothalamic network dysfunction and behavioral deficits in a mouse model of Alzheimer's disease. Neurobiol Aging. 2016 Aug; 44:96-107. PMID: 27318137.
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    22. Goulao M, Lepore AC. iPS cell transplantation for traumatic spinal cord injury. Curr Stem Cell Res Ther. 2016; 11(4):321-8. PMID: 26201863.
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    23. Falnikar A, Hala TJ, Poulsen DJ, Lepore AC. GLT1 overexpression reverses established neuropathic pain-related behavior and attenuates chronic dorsal horn neuron activation following cervical spinal cord injury. Glia. 2016 Mar; 64(3):396-406. PMID: 26496514.
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    24. Li K, Javed E, Scura D, Hala TJ, Seetharam S, Falnikar A, Richard JP, Chorath A, Maragakis NJ, Wright MC, Lepore AC. Human iPS cell-derived astrocyte transplants preserve respiratory function after spinal cord injury. Exp Neurol. 2015 Sep; 271:479-92. PMID: 26216662.
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    25. Ritter DM, Zemel BM, Lepore AC, Covarrubias M. Kv3.4 channel function and dysfunction in nociceptors. Channels (Austin). 2015 Jul 4; 9(4):209-17. PMID: 26039360.
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    26. Martin M, Li K, Wright MC, Lepore AC. Functional and Morphological Assessment of Diaphragm Innervation by Phrenic Motor Neurons. J Vis Exp. 2015; (99). PMID: 26066371.
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    27. Nicaise C, Mitrecic D, Falnikar A, Lepore AC. Transplantation of stem cell-derived astrocytes for the treatment of amyotrophic lateral sclerosis and spinal cord injury. World J Stem Cells. 2015 Mar 26; 7(2):380-98. PMID: 25815122.
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    28. Li K, Hala TJ, Seetharam S, Poulsen DJ, Wright MC, Lepore AC. GLT1 overexpression in SOD1(G93A) mouse cervical spinal cord does not preserve diaphragm function or extend disease. Neurobiol Dis. 2015 Jun; 78:12-23. PMID: 25818008.
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    29. Ritter DM, Zemel BM, Hala TJ, O'Leary ME, Lepore AC, Covarrubias M. Dysregulation of kv3.4 channels in dorsal root Ganglia following spinal cord injury. J Neurosci. 2015 Jan 21; 35(3):1260-73. PMID: 25609640.
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    30. Li K, Javed E, Hala TJ, Sannie D, Regan KA, Maragakis NJ, Wright MC, Poulsen DJ, Lepore AC. Transplantation of Glial Progenitors That Overexpress Glutamate Transporter GLT1 Preserves Diaphragm Function Following Cervical SCI. Mol Ther. 2015 Mar; 23(3):533-48. PMID: 25492561.
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    31. Jablonski MR, Markandaiah SS, Jacob D, Meng NJ, Li K, Gennaro V, Lepore AC, Trotti D, Pasinelli P. Inhibiting drug efflux transporters improves efficacy of ALS therapeutics. Ann Clin Transl Neurol. 2014 Dec; 1(12):996-1005. PMID: 25574474.
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    32. Watson JL, Hala TJ, Putatunda R, Sannie D, Lepore AC. Persistent At-Level Thermal Hyperalgesia and Tactile Allodynia Accompany Chronic Neuronal and Astrocyte Activation in Superficial Dorsal Horn following Mouse Cervical Contusion Spinal Cord Injury. PLoS One. 2014; 9(9):e109099. PMID: 25268642.
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    33. Falnikar A, Li K, Lepore AC. Therapeutically targeting astrocytes with stem and progenitor cell transplantation following traumatic spinal cord injury. Brain Res. 2015 Sep 4; 1619:91-103. PMID: 25251595.
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    34. Allard J, Li K, Lopez XM, Blanchard S, Barbot P, Rorive S, Decaestecker C, Pochet R, Bohl D, Lepore AC, Salmon I, Nicaise C. Immunohistochemical toolkit for tracking and quantifying xenotransplanted human stem cells. Regen Med. 2014 Jul; 9(4):437-52. PMID: 25159062.
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    35. Li K, Nicaise C, Sannie D, Hala TJ, Javed E, Parker JL, Putatunda R, Regan KA, Suain V, Brion JP, Rhoderick F, Wright MC, Poulsen DJ, Lepore AC. Overexpression of the Astrocyte Glutamate Transporter GLT1 Exacerbates Phrenic Motor Neuron Degeneration, Diaphragm Compromise, and Forelimb Motor Dysfunction following Cervical Contusion Spinal Cord Injury. J Neurosci. 2014 May 28; 34(22):7622-38. PMID: 24872566.
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    36. Putatunda R, Hala TJ, Chin J, Lepore AC. Chronic at-level thermal hyperalgesia following rat cervical contusion spinal cord injury is accompanied by neuronal and astrocyte activation and loss of the astrocyte glutamate transporter, GLT1, in superficial dorsal horn. Brain Res. 2014 Sep 18; 1581:64-79. PMID: 24833066.
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    37. Nicaise C, Frank DM, Hala TJ, Authelet M, Pochet R, Adriaens D, Brion JP, Wright MC, Lepore AC. Early phrenic motor neuron loss and transient respiratory abnormalities after unilateral cervical spinal cord contusion. J Neurotrauma. 2013 Jun 15; 30(12):1092-9. PMID: 23534670.
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    38. Nicaise C, Putatunda R, Hala TJ, Regan KA, Frank DM, Brion JP, Leroy K, Pochet R, Wright MC, Lepore AC. Degeneration of Phrenic Motor Neurons Induces Long-Term Diaphragm Deficits following Mid-Cervical Spinal Contusion in Mice. J Neurotrauma. 2012 Dec 10; 29(18):2748-60. PMID: 23176637.
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    39. Nicaise C, Hala TJ, Frank DM, Parker JL, Authelet M, Leroy K, Brion JP, Wright MC, Lepore AC. Phrenic motor neuron degeneration compromises phrenic axonal circuitry and diaphragm activity in a unilateral cervical contusion model of spinal cord injury. Exp Neurol. 2012 Jun; 235(2):539-52. PMID: 22465264.
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    40. Lepore AC, O'Donnell J, Kim AS, Williams T, Tuteja A, Rao MS, Kelley LL, Campanelli JT, Maragakis NJ. Human glial-restricted progenitor transplantation into cervical spinal cord of the SOD1 mouse model of ALS. PLoS One. 2011; 6(10):e25968. PMID: 21998733.
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    41. Papadeas ST, Kraig SE, O'Banion C, Lepore AC, Maragakis NJ. Astrocytes carrying the superoxide dismutase 1 (SOD1G93A) mutation induce wild-type motor neuron degeneration in vivo. Proc Natl Acad Sci U S A. 2011 Oct 25; 108(43):17803-8. PMID: 21969586.
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    42. Lepore AC. Intraspinal cell transplantation for targeting cervical ventral horn in amyotrophic lateral sclerosis and traumatic spinal cord injury. J Vis Exp. 2011; (55). PMID: 21946609.
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    43. Lepore AC, O'Donnell J, Kim AS, Yang EJ, Tuteja A, Haidet-Phillips A, O'Banion CP, Maragakis NJ. Reduction in expression of the astrocyte glutamate transporter, GLT1, worsens functional and histological outcomes following traumatic spinal cord injury. Glia. 2011 Dec; 59(12):1996-2005. PMID: 21882244.
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    44. Lepore AC, O'Donnell J, Bonner JF, Paul C, Miller ME, Rauck B, Kushner RA, Rothstein JD, Fischer I, Maragakis NJ. Spatial and temporal changes in promoter activity of the astrocyte glutamate transporter GLT1 following traumatic spinal cord injury. J Neurosci Res. 2011 Jul; 89(7):1001-17. PMID: 21488085.
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    45. Jin Y, Neuhuber B, Singh A, Bouyer J, Lepore A, Bonner J, Himes T, Campanelli JT, Fischer I. Transplantation of human glial restricted progenitors and derived astrocytes into a contusion model of spinal cord injury. J Neurotrauma. 2011 Apr; 28(4):579-94. PMID: 21222572.
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    46. Lepore AC, Maragakis NJ. Stem cell transplantation for spinal cord neurodegeneration. Methods Mol Biol. 2011; 793:479-93. PMID: 21913120.
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    47. Lepore AC, Tolmie C, O'Donnell J, Wright MC, Dejea C, Rauck B, Hoke A, Ignagni AR, Onders RP, Maragakis NJ. Peripheral hyperstimulation alters site of disease onset and course in SOD1 rats. Neurobiol Dis. 2010 Sep; 39(3):252-64. PMID: 20381620.
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    48. Yang Y, Gozen O, Watkins A, Lorenzini I, Lepore A, Gao Y, Vidensky S, Brennan J, Poulsen D, Won Park J, Li Jeon N, Robinson MB, Rothstein JD. Presynaptic regulation of astroglial excitatory neurotransmitter transporter GLT1. Neuron. 2009 Mar 26; 61(6):880-94. PMID: 19323997.
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    49. Lepore AC, Rauck B, Dejea C, Pardo AC, Rao MS, Rothstein JD, Maragakis NJ. Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease. Nat Neurosci. 2008 Nov; 11(11):1294-301. PMID: 18931666.
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    50. Lepore AC, Dejea C, Carmen J, Rauck B, Kerr DA, Sofroniew MV, Maragakis NJ. Selective ablation of proliferating astrocytes does not affect disease outcome in either acute or chronic models of motor neuron degeneration. Exp Neurol. 2008 Jun; 211(2):423-32. PMID: 18410928.
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    51. Magnus T, Carmen J, Deleon J, Xue H, Pardo AC, Lepore AC, Mattson MP, Rao MS, Maragakis NJ. Adult glial precursor proliferation in mutant SOD1G93A mice. Glia. 2008 Jan 15; 56(2):200-8. PMID: 18023016.
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    52. Lepore AC, Haenggeli C, Gasmi M, Bishop KM, Bartus RT, Maragakis NJ, Rothstein JD. Intraparenchymal spinal cord delivery of adeno-associated virus IGF-1 is protective in the SOD1G93A model of ALS. Brain Res. 2007 Dec 14; 1185:256-65. PMID: 17963733.
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    53. Coksaygan T, Magnus T, Cai J, Mughal M, Lepore A, Xue H, Fischer I, Rao MS. Neurogenesis in Talpha-1 tubulin transgenic mice during development and after injury. Exp Neurol. 2006 Feb; 197(2):475-85. PMID: 16336967.
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    54. Mitsui T, Shumsky JS, Lepore AC, Murray M, Fischer I. Transplantation of neuronal and glial restricted precursors into contused spinal cord improves bladder and motor functions, decreases thermal hypersensitivity, and modifies intraspinal circuitry. J Neurosci. 2005 Oct 19; 25(42):9624-36. PMID: 16237167.
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    55. Lepore AC, Bakshi A, Swanger SA, Rao MS, Fischer I. Neural precursor cells can be delivered into the injured cervical spinal cord by intrathecal injection at the lumbar cord. Brain Res. 2005 May 31; 1045(1-2):206-16. PMID: 15910779.
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    56. Bakshi A, Hunter C, Swanger S, Lepore A, Fischer I. Minimally invasive delivery of stem cells for spinal cord injury: advantages of the lumbar puncture technique. J Neurosurg Spine. 2004 Oct; 1(3):330-7. PMID: 15478372.
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    57. Lepore AC, Han SS, Tyler-Polsz CJ, Cai J, Rao MS, Fischer I. Differential fate of multipotent and lineage-restricted neural precursors following transplantation into the adult CNS. Neuron Glia Biol. 2004 May; 1(2):113-26. PMID: 16520830.
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