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Angelo Lepore

TitleAssoc Professor
InstitutionThomas Jefferson University
DepartmentDepartment of Neurosciences
Address900 Walnut Street
Philadelphia PA 19107
Phone215-503-4200
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    Collapse Research 
    Collapse research activities and funding
    F32NS059155     (LEPORE, ANGELO C.)Mar 1, 2008 - Feb 28, 2011
    NIH/NINDS
    Transplantation of glial precursors: Astrocyte replacement in ALS
    Role: Principal Investigator

    R01NS079702     (LEPORE, ANGELO C.)Mar 1, 2013 - Feb 28, 2023
    NIH/NINDS
    Exploring mechanisms of axon growth and circuit connectivity for promoting respiratory function recovery following cervical spinal cord injury
    Role: Principal Investigator

    R56NS096028     (LEPORE, ANGELO C.)Sep 25, 2017 - Aug 31, 2018
    NIH/NINDS
    Targeting chronic neuropathic pain after SCI using human iPS cell transplantation
    Role: Principal Investigator

    R01NS110385     (LEPORE, ANGELO C.)Sep 1, 2018 - Aug 31, 2023
    NIH/NINDS
    Exploring the EphB2-NMDA receptor interaction in spinal cord injury-induced neuropathic pain
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Charsar BA, Brinton MA, Locke K, Chen AY, Ghosh B, Urban MW, Komaravolu S, Krishnamurthy K, Smit R, Pasinelli P, Wright MC, Smith GM, Lepore AC. AAV2-BDNF promotes respiratory axon plasticity and recovery of diaphragm function following spinal cord injury. FASEB J. 2019 Oct 02; fj201901730R. PMID: 31577916.
      View in: PubMed
    2. Urban MW, Ghosh B, Block CG, Strojny LR, Charsar BA, Goulão M, Komaravolu SS, Smith GM, Wright MC, Li S, Lepore AC. Long-distance axon regeneration promotes recovery of diaphragmatic respiratory function after spinal cord injury. eNeuro. 2019 Aug 19. PMID: 31427403.
      View in: PubMed
    3. Urban MW, Ghosh B, Block CG, Charsar BA, Smith GM, Wright MC, Li S, Lepore AC. PTPs inhibitory peptide promotes recovery of diaphragm function and sprouting of bulbospinal respiratory axons following cervical spinal cord injury. J Neurotrauma. 2019 Aug 08. PMID: 31392919.
      View in: PubMed
    4. Ghosh B, Nong J, Wang Z, Urban MW, Heinsinger NM, Trovillion VA, Wright MC, Lepore AC, Zhong Y. A hydrogel engineered to deliver minocycline locally to the injured cervical spinal cord protects respiratory neural circuitry and preserves diaphragm function. Neurobiol Dis. 2019 Apr 25; 127:591-604. PMID: 31028873.
      View in: PubMed
    5. Goulão M, Ghosh B, Urban MW, Sahu M, Mercogliano C, Charsar BA, Komaravolu S, Block CG, Smith GM, Wright MC, Lepore AC. Astrocyte progenitor transplantation promotes regeneration of bulbospinal respiratory axons, recovery of diaphragm function, and a reduced macrophage response following cervical spinal cord injury. Glia. 2019 03; 67(3):452-466. PMID: 30548313.
      View in: PubMed
    6. Ghosh B, Wang Z, Nong J, Urban MW, Zhang Z, Trovillion VA, Wright MC, Zhong Y, Lepore AC. Local BDNF Delivery to the Injured Cervical Spinal Cord using an Engineered Hydrogel Enhances Diaphragmatic Respiratory Function. J Neurosci. 2018 Jun 27; 38(26):5982-5995. PMID: 29891731.
      View in: PubMed
    7. Muqeem T, Ghosh B, Pinto V, Lepore AC, Covarrubias M. Regulation of nociceptive glutamatergic signaling by presynaptic Kv3.4 channels in the rat spinal dorsal horn. J Neurosci. 2018 Mar 14. PMID: 29540546.
      View in: PubMed
    8. Falnikar A, Stratton J, Lin R, Andrews CE, Tyburski A, Trovillion VA, Gottschalk C, Ghosh B, Iacovitti L, Elliott MB, Lepore AC. Differential response in novel stem cell niches of the brain following cervical spinal cord injury and traumatic brain injury. J Neurotrauma. 2018 Feb 22. PMID: 29471717.
      View in: PubMed
    9. Urban MW, Ghosh B, Strojny LR, Block CG, Blazejewski SM, Wright MC, Smith GM, Lepore AC. Cell-type specific expression of constitutively-active Rheb promotes regeneration of bulbospinal respiratory axons following cervical SCI. Exp Neurol. 2018 May; 303:108-119. PMID: 29453976.
      View in: PubMed
    10. Gomes ED, Mendes SS, Assunção-Silva RC, Teixeira FG, Pires AO, Anjo SI, Manadas B, Leite-Almeida H, Gimble JM, Sousa N, Lepore AC, Silva NA, Salgado AJ. Cotransplantation of Adipose Tissue-Derived Stromal Cells and Olfactory Ensheathing Cells for Spinal Cord Injury Repair. Stem Cells. 2018 Jan 20. PMID: 29352743.
      View in: PubMed
    11. Zemel BM, Muqeem T, Brown EV, Goulão M, Urban MW, Tymanskyj SR, Lepore AC, Covarrubias M. Calcineurin dysregulation underlies spinal cord injury-induced K+ channel dysfunction in DRG neurons. J Neurosci. 2017 Jul 27. PMID: 28751455.
      View in: PubMed
    12. Rosenblum LT, Shamamandri-Markandaiah S, Ghosh B, Foran E, Lepore AC, Pasinelli P, Trotti D. Mutation of the caspase-3 cleavage site in the astroglial glutamate transporter EAAT2 delays disease progression and extends lifespan in the SOD1-G93A mouse model of ALS. Exp Neurol. 2017 Jun; 292:145-153. PMID: 28342750.
      View in: PubMed
    13. Tymanskyj SR, Yang B, Falnikar A, Lepore AC, Ma L. MAP7 Regulates Axon Collateral Branch Development in Dorsal Root Ganglion Neurons. J Neurosci. 2017 Feb 08; 37(6):1648-1661. PMID: 28069923.
      View in: PubMed
    14. Lane MA, Lepore AC, Fischer I. Improving the therapeutic efficacy of neural progenitor cell transplantation following spinal cord injury. Expert Rev Neurother. 2016 Dec 07. PMID: 27927055.
      View in: PubMed
    15. Charsar BA, Urban MW, Lepore AC. Harnessing the power of cell transplantation to target respiratory dysfunction following spinal cord injury. Exp Neurol. 2017 Jan; 287(Pt 2):268-275. PMID: 27531634.
      View in: PubMed
    16. Hazra A, Corbett BF, You JC, Aschmies S, Zhao L, Li K, Lepore AC, Marsh ED, Chin J. Corticothalamic network dysfunction and behavioral deficits in a mouse model of Alzheimer's disease. Neurobiol Aging. 2016 Aug; 44:96-107. PMID: 27318137.
      View in: PubMed
    17. Goulao M, Lepore AC. iPS cell transplantation for traumatic spinal cord injury. Curr Stem Cell Res Ther. 2016; 11(4):321-8. PMID: 26201863.
      View in: PubMed
    18. Falnikar A, Hala TJ, Poulsen DJ, Lepore AC. GLT1 overexpression reverses established neuropathic pain-related behavior and attenuates chronic dorsal horn neuron activation following cervical spinal cord injury. Glia. 2016 Mar; 64(3):396-406. PMID: 26496514.
      View in: PubMed
    19. Li K, Javed E, Scura D, Hala TJ, Seetharam S, Falnikar A, Richard JP, Chorath A, Maragakis NJ, Wright MC, Lepore AC. Human iPS cell-derived astrocyte transplants preserve respiratory function after spinal cord injury. Exp Neurol. 2015 Sep; 271:479-92. PMID: 26216662.
      View in: PubMed
    20. Ritter DM, Zemel BM, Lepore AC, Covarrubias M. Kv3.4 channel function and dysfunction in nociceptors. Channels (Austin). 2015 Jul 4; 9(4):209-17. PMID: 26039360.
      View in: PubMed
    21. Martin M, Li K, Wright MC, Lepore AC. Functional and Morphological Assessment of Diaphragm Innervation by Phrenic Motor Neurons. J Vis Exp. 2015; (99). PMID: 26066371.
      View in: PubMed
    22. Nicaise C, Mitrecic D, Falnikar A, Lepore AC. Transplantation of stem cell-derived astrocytes for the treatment of amyotrophic lateral sclerosis and spinal cord injury. World J Stem Cells. 2015 Mar 26; 7(2):380-98. PMID: 25815122.
      View in: PubMed
    23. Li K, Hala TJ, Seetharam S, Poulsen DJ, Wright MC, Lepore AC. GLT1 overexpression in SOD1(G93A) mouse cervical spinal cord does not preserve diaphragm function or extend disease. Neurobiol Dis. 2015 Jun; 78:12-23. PMID: 25818008.
      View in: PubMed
    24. Ritter DM, Zemel BM, Hala TJ, O'Leary ME, Lepore AC, Covarrubias M. Dysregulation of kv3.4 channels in dorsal root Ganglia following spinal cord injury. J Neurosci. 2015 Jan 21; 35(3):1260-73. PMID: 25609640.
      View in: PubMed
    25. Li K, Javed E, Hala TJ, Sannie D, Regan KA, Maragakis NJ, Wright MC, Poulsen DJ, Lepore AC. Transplantation of Glial Progenitors That Overexpress Glutamate Transporter GLT1 Preserves Diaphragm Function Following Cervical SCI. Mol Ther. 2015 Mar; 23(3):533-48. PMID: 25492561.
      View in: PubMed
    26. Jablonski MR, Markandaiah SS, Jacob D, Meng NJ, Li K, Gennaro V, Lepore AC, Trotti D, Pasinelli P. Inhibiting drug efflux transporters improves efficacy of ALS therapeutics. Ann Clin Transl Neurol. 2014 Dec; 1(12):996-1005. PMID: 25574474.
      View in: PubMed
    27. Watson JL, Hala TJ, Putatunda R, Sannie D, Lepore AC. Persistent At-Level Thermal Hyperalgesia and Tactile Allodynia Accompany Chronic Neuronal and Astrocyte Activation in Superficial Dorsal Horn following Mouse Cervical Contusion Spinal Cord Injury. PLoS One. 2014; 9(9):e109099. PMID: 25268642.
      View in: PubMed
    28. Falnikar A, Li K, Lepore AC. Therapeutically targeting astrocytes with stem and progenitor cell transplantation following traumatic spinal cord injury. Brain Res. 2015 Sep 4; 1619:91-103. PMID: 25251595.
      View in: PubMed
    29. Allard J, Li K, Lopez XM, Blanchard S, Barbot P, Rorive S, Decaestecker C, Pochet R, Bohl D, Lepore AC, Salmon I, Nicaise C. Immunohistochemical toolkit for tracking and quantifying xenotransplanted human stem cells. Regen Med. 2014 Jul; 9(4):437-52. PMID: 25159062.
      View in: PubMed
    30. Li K, Nicaise C, Sannie D, Hala TJ, Javed E, Parker JL, Putatunda R, Regan KA, Suain V, Brion JP, Rhoderick F, Wright MC, Poulsen DJ, Lepore AC. Overexpression of the Astrocyte Glutamate Transporter GLT1 Exacerbates Phrenic Motor Neuron Degeneration, Diaphragm Compromise, and Forelimb Motor Dysfunction following Cervical Contusion Spinal Cord Injury. J Neurosci. 2014 May 28; 34(22):7622-38. PMID: 24872566.
      View in: PubMed
    31. Putatunda R, Hala TJ, Chin J, Lepore AC. Chronic at-level thermal hyperalgesia following rat cervical contusion spinal cord injury is accompanied by neuronal and astrocyte activation and loss of the astrocyte glutamate transporter, GLT1, in superficial dorsal horn. Brain Res. 2014 Sep 18; 1581:64-79. PMID: 24833066.
      View in: PubMed
    32. Nicaise C, Frank DM, Hala TJ, Authelet M, Pochet R, Adriaens D, Brion JP, Wright MC, Lepore AC. Early phrenic motor neuron loss and transient respiratory abnormalities after unilateral cervical spinal cord contusion. J Neurotrauma. 2013 Jun 15; 30(12):1092-9. PMID: 23534670.
      View in: PubMed
    33. Nicaise C, Putatunda R, Hala TJ, Regan KA, Frank DM, Brion JP, Leroy K, Pochet R, Wright MC, Lepore AC. Degeneration of Phrenic Motor Neurons Induces Long-Term Diaphragm Deficits following Mid-Cervical Spinal Contusion in Mice. J Neurotrauma. 2012 Dec 10; 29(18):2748-60. PMID: 23176637.
      View in: PubMed
    34. Nicaise C, Hala TJ, Frank DM, Parker JL, Authelet M, Leroy K, Brion JP, Wright MC, Lepore AC. Phrenic motor neuron degeneration compromises phrenic axonal circuitry and diaphragm activity in a unilateral cervical contusion model of spinal cord injury. Exp Neurol. 2012 Jun; 235(2):539-52. PMID: 22465264.
      View in: PubMed
    35. Lepore AC, O'Donnell J, Kim AS, Williams T, Tuteja A, Rao MS, Kelley LL, Campanelli JT, Maragakis NJ. Human glial-restricted progenitor transplantation into cervical spinal cord of the SOD1 mouse model of ALS. PLoS One. 2011; 6(10):e25968. PMID: 21998733.
      View in: PubMed
    36. Papadeas ST, Kraig SE, O'Banion C, Lepore AC, Maragakis NJ. Astrocytes carrying the superoxide dismutase 1 (SOD1G93A) mutation induce wild-type motor neuron degeneration in vivo. Proc Natl Acad Sci U S A. 2011 Oct 25; 108(43):17803-8. PMID: 21969586.
      View in: PubMed
    37. Lepore AC. Intraspinal cell transplantation for targeting cervical ventral horn in amyotrophic lateral sclerosis and traumatic spinal cord injury. J Vis Exp. 2011; (55). PMID: 21946609.
      View in: PubMed
    38. Lepore AC, O'Donnell J, Kim AS, Yang EJ, Tuteja A, Haidet-Phillips A, O'Banion CP, Maragakis NJ. Reduction in expression of the astrocyte glutamate transporter, GLT1, worsens functional and histological outcomes following traumatic spinal cord injury. Glia. 2011 Dec; 59(12):1996-2005. PMID: 21882244.
      View in: PubMed
    39. Lepore AC, O'Donnell J, Bonner JF, Paul C, Miller ME, Rauck B, Kushner RA, Rothstein JD, Fischer I, Maragakis NJ. Spatial and temporal changes in promoter activity of the astrocyte glutamate transporter GLT1 following traumatic spinal cord injury. J Neurosci Res. 2011 Jul; 89(7):1001-17. PMID: 21488085.
      View in: PubMed
    40. Jin Y, Neuhuber B, Singh A, Bouyer J, Lepore A, Bonner J, Himes T, Campanelli JT, Fischer I. Transplantation of human glial restricted progenitors and derived astrocytes into a contusion model of spinal cord injury. J Neurotrauma. 2011 Apr; 28(4):579-94. PMID: 21222572.
      View in: PubMed
    41. Lepore AC, Maragakis NJ. Stem cell transplantation for spinal cord neurodegeneration. Methods Mol Biol. 2011; 793:479-93. PMID: 21913120.
      View in: PubMed
    42. Lepore AC, Tolmie C, O'Donnell J, Wright MC, Dejea C, Rauck B, Hoke A, Ignagni AR, Onders RP, Maragakis NJ. Peripheral hyperstimulation alters site of disease onset and course in SOD1 rats. Neurobiol Dis. 2010 Sep; 39(3):252-64. PMID: 20381620.
      View in: PubMed
    43. Yang Y, Gozen O, Watkins A, Lorenzini I, Lepore A, Gao Y, Vidensky S, Brennan J, Poulsen D, Won Park J, Li Jeon N, Robinson MB, Rothstein JD. Presynaptic regulation of astroglial excitatory neurotransmitter transporter GLT1. Neuron. 2009 Mar 26; 61(6):880-94. PMID: 19323997.
      View in: PubMed
    44. Lepore AC, Rauck B, Dejea C, Pardo AC, Rao MS, Rothstein JD, Maragakis NJ. Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease. Nat Neurosci. 2008 Nov; 11(11):1294-301. PMID: 18931666.
      View in: PubMed
    45. Lepore AC, Dejea C, Carmen J, Rauck B, Kerr DA, Sofroniew MV, Maragakis NJ. Selective ablation of proliferating astrocytes does not affect disease outcome in either acute or chronic models of motor neuron degeneration. Exp Neurol. 2008 Jun; 211(2):423-32. PMID: 18410928.
      View in: PubMed
    46. Magnus T, Carmen J, Deleon J, Xue H, Pardo AC, Lepore AC, Mattson MP, Rao MS, Maragakis NJ. Adult glial precursor proliferation in mutant SOD1G93A mice. Glia. 2008 Jan 15; 56(2):200-8. PMID: 18023016.
      View in: PubMed
    47. Lepore AC, Haenggeli C, Gasmi M, Bishop KM, Bartus RT, Maragakis NJ, Rothstein JD. Intraparenchymal spinal cord delivery of adeno-associated virus IGF-1 is protective in the SOD1G93A model of ALS. Brain Res. 2007 Dec 14; 1185:256-65. PMID: 17963733.
      View in: PubMed
    48. Coksaygan T, Magnus T, Cai J, Mughal M, Lepore A, Xue H, Fischer I, Rao MS. Neurogenesis in Talpha-1 tubulin transgenic mice during development and after injury. Exp Neurol. 2006 Feb; 197(2):475-85. PMID: 16336967.
      View in: PubMed
    49. Mitsui T, Shumsky JS, Lepore AC, Murray M, Fischer I. Transplantation of neuronal and glial restricted precursors into contused spinal cord improves bladder and motor functions, decreases thermal hypersensitivity, and modifies intraspinal circuitry. J Neurosci. 2005 Oct 19; 25(42):9624-36. PMID: 16237167.
      View in: PubMed
    50. Lepore AC, Bakshi A, Swanger SA, Rao MS, Fischer I. Neural precursor cells can be delivered into the injured cervical spinal cord by intrathecal injection at the lumbar cord. Brain Res. 2005 May 31; 1045(1-2):206-16. PMID: 15910779.
      View in: PubMed
    51. Bakshi A, Hunter C, Swanger S, Lepore A, Fischer I. Minimally invasive delivery of stem cells for spinal cord injury: advantages of the lumbar puncture technique. J Neurosurg Spine. 2004 Oct; 1(3):330-7. PMID: 15478372.
      View in: PubMed
    52. Lepore AC, Han SS, Tyler-Polsz CJ, Cai J, Rao MS, Fischer I. Differential fate of multipotent and lineage-restricted neural precursors following transplantation into the adult CNS. Neuron Glia Biol. 2004 May; 1(2):113-26. PMID: 16520830.
      View in: PubMed
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