Thomas Jefferson University

Andrea Morrione

TitleAdjunct Faculty Nonexempt
InstitutionThomas Jefferson University
DepartmentAdministration - Thomas Jefferson University
Address1020 Locust Street
Philadelphia PA 19107
Phone2155034519
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    Collapse Overview 
    Collapse overview
    Cell signaling
    cell transformation
    bladder cancer
    growth factors and growth factor receptors

    Collapse Research 
    Collapse research activities and funding
    K01DK002896     (MORRIONE, ANDREA C)Sep 1, 2000 - Aug 31, 2003
    NIH
    ROLE OF MGRB10 IN IGF-I INDUCED SIGNALING
    Role: Principal Investigator
    R01DK068419     (MORRIONE, ANDREA)May 1, 2005 - Mar 31, 2011
    NIH
    Proepithelin Signaling in Urothelial Cells
    Role: Principal Investigator
    R01CA164462     (IOZZO, RENATO V.)Sep 1, 2012 - Jun 30, 2018
    NIH
    Progranulin signaling in bladder cancer
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Toracchio L, Carrabotta M, Mancarella C, Morrione A, Scotlandi K. EphA2 in Cancer: Molecular Complexity and Therapeutic Opportunities. Int J Mol Sci. 2024 Nov 13; 25(22). PMID: 39596256.
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    2. Andretta E, Costa A, Ventura E, Quintiliani M, Damiano S, Giordano A, Morrione A, Ciarcia R. Capsaicin Exerts Antitumor Activity in Mesothelioma Cells. Nutrients. 2024 Nov 01; 16(21). PMID: 39519591.
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    3. Tomassetti C, Insinga G, Gimigliano F, Morrione A, Giordano A, Giurisato E. Insights into CSF-1R Expression in the Tumor Microenvironment. Biomedicines. 2024 Oct 18; 12(10). PMID: 39457693.
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    4. Buraschi S, Xu SQ, Stefanello M, Moskalev I, Morcavallo A, Genua M, Tanimoto R, Birbe R, Peiper SC, Gomella LG, Belfiore A, Black PC, Iozzo RV, Morrione A. Correction: Suppression of progranulin expression inhibits bladder cancer growth and sensitizes cancer cells to cisplatin. Oncotarget. 2024 10 01; 15:697-698. PMID: 39352802.
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    5. Costa A, Forte IM, Pentimalli F, Iannuzzi CA, Alfano L, Capone F, Camerlingo R, Calabrese A, von Arx C, Benot Dominguez R, Quintiliani M, De Laurentiis M, Morrione A, Giordano A. Pharmacological inhibition of CDK4/6 impairs diffuse pleural mesothelioma 3D spheroid growth and reduces viability of cisplatin-resistant cells. Front Oncol. 2024; 14:1418951. PMID: 39011477.
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    6. Mancarella C, Morrione A, Scotlandi K. Extracellular Interactors of the IGF System: Impact on Cancer Hallmarks and Therapeutic Approaches. Int J Mol Sci. 2024 May 29; 25(11). PMID: 38892104.
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    7. Canciello A, Dom?nguez RB, Barboni B, Giordano A, Morrione A. Characterization of KLHL14 anti-oncogenic action in malignant mesothelioma. Heliyon. 2024 Mar 30; 10(6):e27731. PMID: 38509883.
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    8. Rosati D, Palmieri M, Brunelli G, Morrione A, Iannelli F, Frullanti E, Giordano A. Differential gene expression analysis pipelines and bioinformatic tools for the identification of specific biomarkers: A review. Comput Struct Biotechnol J. 2024 Dec; 23:1154-1168. PMID: 38510977.
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    9. Cersosimo F, Lonardi S, Ulivieri C, Martini P, Morrione A, Vermi W, Giordano A, Giurisato E. CSF-1R in Cancer: More than a Myeloid Cell Receptor. Cancers (Basel). 2024 Jan 09; 16(2). PMID: 38254773.
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    10. Costagliola A, Lombardi R, Liguori G, Morrione A, Giordano A. Orexins and Prostate Cancer: State of the Art and Potential Experimental and Therapeutic Perspectives. Cancer Genomics Proteomics. 2023 Dec; 20(6suppl):637-645. PMID: 38035703.
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    11. Mancarella C, Morrione A, Scotlandi K. PROTAC-Based Protein Degradation as a Promising Strategy for Targeted Therapy in Sarcomas. Int J Mol Sci. 2023 Nov 15; 24(22). PMID: 38003535.
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    12. Ventura E, Belfiore A, Iozzo RV, Giordano A, Morrione A. Progranulin and EGFR modulate RYK (Receptor like Tyrosine Kinase) sorting and stability in mesothelioma cells. Am J Physiol Cell Physiol. 2023 Jul 03. PMID: 37399497.
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    13. Ventura E, Ducci G, Benot Dominguez R, Ruggiero V, Belfiore A, Sacco E, Vanoni M, Iozzo RV, Giordano A, Morrione A. Progranulin Oncogenic Network in Solid Tumors. Cancers (Basel). 2023 Mar 10; 15(6). PMID: 36980592.
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    14. Flammia RS, Tufano A, Chierigo F, W?rnschimmel C, Hoeh B, Sorce G, Tian Z, Anceschi U, Leonardo C, Del Giudice F, Terrone C, Giordano A, Morrione A, Saad F, Shariat SF, Briganti A, Montorsi F, Chun FKH, Gallucci M, Karakiewicz PI. The Effect of Sex on Disease Stage and Survival after Radical Cystectomy in Non-Urothelial Variant-Histology Bladder Cancer. J Clin Med. 2023 Feb 23; 12(5). PMID: 36902562.
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    15. Belfiore A, Rapicavoli RV, Le Moli R, Lappano R, Morrione A, De Francesco EM, Vella V. IGF2: A Role in Metastasis and Tumor Evasion from Immune Surveillance? Biomedicines. 2023 Jan 16; 11(1). PMID: 36672737.
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    16. Ciccarelli G, Conte S, Cimmino G, Maiorano P, Morrione A, Giordano A. Mitochondrial Dysfunction: The Hidden Player in the Pathogenesis of Atherosclerosis? Int J Mol Sci. 2023 Jan 06; 24(2). PMID: 36674602.
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    17. Ventura E, Xie C, Buraschi S, Belfiore A, Iozzo RV, Giordano A, Morrione A. Complexity of progranulin mechanisms of action in mesothelioma. J Exp Clin Cancer Res. 2022 Dec 05; 41(1):333. PMID: 36471440.
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    18. Canciello A, Cerver?-Varona A, Peserico A, Mauro A, Russo V, Morrione A, Giordano A, Barboni B. "In medio stat virtus": Insights into hybrid E/M phenotype attitudes. Front Cell Dev Biol. 2022; 10:1038841. PMID: 36467417.
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    19. Rossi E, Mutti L, Morrione A, Giordano A. Neuro-Immune Interactions in Severe COVID-19 Infection. Pathogens. 2022 Oct 29; 11(11). PMID: 36365007.
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    20. Tufano A, Cordua N, Nardone V, Ranavolo R, Flammia RS, D'Antonio F, Borea F, Anceschi U, Leonardo C, Morrione A, Giordano A. Prognostic Significance of Organ-Specific Metastases in Patients with Metastatic Upper Tract Urothelial Carcinoma. J Clin Med. 2022 Sep 09; 11(18). PMID: 36142956.
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    21. Morrione A, Belfiore A. Obesity, Diabetes, and Cancer: The Role of the Insulin/IGF Axis; Mechanisms and Clinical Implications. Biomolecules. 2022 Apr 20; 12(5). PMID: 35625539.
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    22. Marei HE, Althani A, Afifi N, Hasan A, Caceci T, Pozzoli G, Morrione A, Giordano A, Cenciarelli C. p53 signaling in cancer progression and therapy. Cancer Cell Int. 2021 Dec 24; 21(1):703. PMID: 34952583.
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    23. Vella V, Giuliano M, La Ferlita A, Pellegrino M, Gaudenzi G, Alaimo S, Massimino M, Pulvirenti A, Dicitore A, Vigneri P, Vitale G, Malaguarnera R, Morrione A, Sims AH, Ferro A, Maggiolini M, Lappano R, De Francesco EM, Belfiore A. Novel Mechanisms of Tumor Promotion by the Insulin Receptor Isoform A in Triple-Negative Breast Cancer Cells. Cells. 2021 11 12; 10(11). PMID: 34831367.
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    24. Ventura E, Iannuzzi CA, Pentimalli F, Giordano A, Morrione A. RBL1/p107 Expression Levels Are Modulated by Multiple Signaling Pathways. Cancers (Basel). 2021 Oct 08; 13(19). PMID: 34638509.
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    25. Mancarella C, Morrione A, Scotlandi K. Unraveling the IGF System Interactome in Sarcomas Exploits Novel Therapeutic Options. Cells. 2021 Aug 13; 10(8). PMID: 34440844.
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    26. Vella V, Giuliano M, Nicolosi ML, Majorana MG, Marc MA, Muoio MG, Morrione A, Maggiolini M, Lappano R, De Francesco EM, Belfiore A. DDR1 Affects Metabolic Reprogramming in Breast Cancer Cells by Cross-Talking to the Insulin/IGF System. Biomolecules. 2021 06 22; 11(7). PMID: 34206590.
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    27. Mancarella C, Morrione A, Scotlandi K. Novel Regulators of the IGF System in Cancer. Biomolecules. 2021 02 12; 11(2). PMID: 33673232.
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    28. Mancarella C, Caldoni G, Ribolsi I, Parra A, Manara MC, Mercurio AM, Morrione A, Scotlandi K. Insulin-Like Growth Factor 2 mRNA-Binding Protein 3 Modulates Aggressiveness of Ewing Sarcoma by Regulating the CD164-CXCR4 Axis. Front Oncol. 2020; 10:994. PMID: 32719743.
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    29. Buraschi S, Neill T, Xu SQ, Palladino C, Belfiore A, Iozzo RV, Morrione A. Progranulin/EphA2 axis: A novel oncogenic mechanism in bladder cancer. Matrix Biol. 2020 May 15. PMID: 32417448.
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    30. Buraschi S, Morcavallo A, Neill T, Stefanello M, Palladino C, Xu SQ, Belfiore A, Iozzo RV, Morrione A. Discoidin Domain Receptor 1 functionally interacts with the IGF-I system in bladder cancer. Matrix Biol Plus. 2020 May; 6-7:100022. PMID: 33543020.
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    31. Vella V, Nicolosi ML, Giuliano M, Morrione A, Malaguarnera R, Belfiore A. Insulin Receptor Isoform A Modulates Metabolic Reprogramming of Breast Cancer Cells in Response to IGF2 and Insulin Stimulation. Cells. 2019 Sep 01; 8(9). PMID: 31480557.
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    32. Vella V, Malaguarnera R, Nicolosi ML, Morrione A, Belfiore A. Insulin/IGF signaling and discoidin domain receptors: An emerging functional connection. Biochim Biophys Acta Mol Cell Res. 2019 Aug 05; 118522. PMID: 31394114.
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    33. Vella V, Nicolosi ML, Cantafio P, Massimino M, Lappano R, Vigneri P, Ciuni R, Gangemi P, Morrione A, Malaguarnera R, Belfiore A. DDR1 regulates thyroid cancer cell differentiation via IGF-2/IR-A autocrine signaling loop. Endocr Relat Cancer. 2018 Aug 18. PMID: 30121624.
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    34. Belfiore A, Malaguarnera R, Nicolosi ML, Lappano R, Ragusa M, Morrione A, Vella V. A novel functional crosstalk between DDR1 and the IGF axis and its relevance for breast cancer. Cell Adh Migr. 2018 Mar 23; 1-10. PMID: 29486622.
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    35. Xu SQ, Buraschi S, Tanimoto R, Stefanello M, Belfiore A, Iozzo RV, Morrione A. Analysis of Progranulin-Mediated Akt and MAPK Activation. Methods Mol Biol. 2018; 1806:121-130. PMID: 29956273.
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    36. Belfiore A, Malaguarnera R, Vella V, Lawrence MC, Sciacca L, Frasca F, Morrione A, Vigneri R. Insulin Receptor Isoforms in Physiology and Disease: An Updated View. Endocr Rev. 2017 Oct 01; 38(5):379-431. PMID: 28973479.
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    37. Vella V, Malaguarnera R, Luisa Nicolosi M, Palladino C, Spoleti C, Massimino M, Vigneri P, Purrello M, Ragusa M, Morrione A, Belfiore A. Discoidin domain receptor 1 modulates insulin receptor signaling and biological responses in breast cancer cells. Oncotarget. 2017 Jun 27; 8(26):43248-43270. PMID: 28591735.
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    38. Tanimoto R, Palladino C, Xu SQ, Buraschi S, Neill T, Gomella LG, Peiper SC, Belfiore A, Iozzo RV, Morrione A. The perlecan-interacting growth factor progranulin regulates ubiquitination, sorting, and lysosomal degradation of sortilin. Matrix Biol. 2017 Dec; 64:27-39. PMID: 28433812.
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    39. Neill T, Buraschi S, Goyal A, Sharpe C, Natkanski E, Schaefer L, Morrione A, Iozzo RV. EphA2 is a functional receptor for the growth factor progranulin. J Cell Biol. 2016 Dec 05; 215(5):687-703. PMID: 27903606.
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    40. Manara MC, Terracciano M, Mancarella C, Sciandra M, Guerzoni C, Pasello M, Grilli A, Zini N, Picci P, Colombo MP, Morrione A, Scotlandi K. CD99 triggering induces methuosis of Ewing sarcoma cells through IGF-1R/RAS/Rac1 signaling. Oncotarget. 2016 Nov 7. PMID: 27835596.
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    41. Tanimoto R, Lu KG, Xu SQ, Buraschi S, Belfiore A, Iozzo RV, Morrione A. Mechanisms of Progranulin Action and Regulation in Genitourinary Cancers. Front Endocrinol (Lausanne). 2016; 7:100. PMID: 27512385.
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    42. Buraschi S, Xu SQ, Stefanello M, Moskalev I, Morcavallo A, Genua M, Tanimoto R, Birbe R, Peiper SC, Gomella LG, Belfiore A, Black PC, Iozzo RV, Morrione A. Suppression of progranulin expression inhibits bladder cancer growth and sensitizes cancer cells to cisplatin. Oncotarget. 2016 Jun 28; 7(26):39980-39995. PMID: 27220888.
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    43. Matà R, Palladino C, Nicolosi ML, Lo Presti AR, Malaguarnera R, Ragusa M, Sciortino D, Morrione A, Maggiolini M, Vella V, Belfiore A. IGF-I induces upregulation of DDR1 collagen receptor in breast cancer cells by suppressing MIR-199a-5p through the PI3K/AKT pathway. Oncotarget. 2016 Feb 16; 7(7):7683-700. PMID: 26655502.
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    44. Malaguarnera R, Nicolosi ML, Sacco A, Morcavallo A, Vella V, Voci C, Spatuzza M, Xu SQ, Iozzo RV, Vigneri R, Morrione A, Belfiore A. Novel cross talk between IGF-IR and DDR1 regulates IGF-IR trafficking, signaling and biological responses. Oncotarget. 2015 Jun 30; 6(18):16084-105. PMID: 25840417.
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    45. Xu SQ, Buraschi S, Morcavallo A, Genua M, Shirao T, Peiper SC, Gomella LG, Birbe R, Belfiore A, Iozzo RV, Morrione A. A novel role for drebrin in regulating progranulin bioactivity in bladder cancer. Oncotarget. 2015 May 10; 6(13):10825-39. PMID: 25839164.
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    46. Tanimoto R, Morcavallo A, Terracciano M, Xu SQ, Stefanello M, Buraschi S, Lu KG, Bagley DH, Gomella LG, Scotlandi K, Belfiore A, Iozzo RV, Morrione A. Sortilin regulates progranulin action in castration-resistant prostate cancer cells. Endocrinology. 2015 Jan; 1(1):58-70. PMID: 25365768.
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    47. Morcavallo A, Stefanello M, Iozzo RV, Belfiore A, Morrione A. Ligand-mediated endocytosis and trafficking of the insulin-like growth factor receptor I and insulin receptor modulate receptor function. Front Endocrinol (Lausanne). 2014; 5:220. PMID: 25566192.
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    48. Malaguarnera R, Sacco A, Morcavallo A, Squatrito S, Migliaccio A, Morrione A, Maggiolini M, Belfiore A. Metformin Inhibits Androgen-Induced IGF-IR Up-Regulation in Prostate Cancer Cells by Disrupting Membrane-Initiated Androgen Signaling. Endocrinology. 2014 Apr; 155(4):1207-21. PMID: 24437490.
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    49. Morcavallo A, Buraschi S, Xu SQ, Belfiore A, Schaefer L, Iozzo RV, Morrione A. Decorin differentially modulates the activity of insulin receptor isoform A ligands. Matrix Biol. 2014 Apr; 35:82-90. PMID: 24389353.
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    50. Deangelis T, Quong A, Morrione A, Baserga R. Growth of v-src-transformed cells in serum-free medium through the induction of growth factors. J Cell Physiol. 2013 Jul; 228(7):1482-6. PMID: 23254450.
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    51. Goel HL, Sayeed A, Breen M, Zarif MJ, Garlick DS, Leav I, Davis RJ, Fitzgerald TJ, Morrione A, Hsieh CC, Liu Q, Dicker AP, Altieri DC, Languino LR. ß1 integrins mediate resistance to ionizing radiation in vivo by inhibiting c-Jun amino terminal kinase 1. J Cell Physiol. 2013 Jul; 228(7):1601-9. PMID: 23359252.
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    52. Morrione A, Neill T, Iozzo RV. Dichotomy of decorin activity on the insulin-like growth factor-I system. FEBS J. 2013 May; 280(10):2138-49. PMID: 23351020.
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    53. Genua M, Xu SQ, Buraschi S, Peiper SC, Gomella LG, Belfiore A, Iozzo RV, Morrione A. Proline-rich tyrosine kinase 2 (Pyk2) regulates IGF-I-induced cell motility and invasion of urothelial carcinoma cells. PLoS One. 2012; 7(6):e40148. PMID: 22859931.
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    54. Morcavallo A, Genua M, Palummo A, Kletvikova E, Jiracek J, Brzozowski AM, Iozzo RV, Belfiore A, Morrione A. Insulin and insulin-like growth factor II differentially regulate endocytic sorting and stability of insulin receptor isoform A. J Biol Chem. 2012 Mar 30; 287(14):11422-36. PMID: 22318726.
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    55. Iozzo RV, Buraschi S, Genua M, Xu SQ, Solomides CC, Peiper SC, Gomella LG, Owens RC, Morrione A. Decorin antagonizes IGF receptor I (IGF-IR) function by interfering with IGF-IR activity and attenuating downstream signaling. J Biol Chem. 2011 Oct 7; 286(40):34712-21. PMID: 21840990.
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    56. Sacco E, Metalli D, Spinelli M, Manzoni R, Samalikova M, Grandori R, Morrione A, Traversa S, Alberghina L, Vanoni M. Novel RasGRF1-derived Tat-fused peptides inhibiting Ras-dependent proliferation and migration in mouse and human cancer cells. Biotechnol Adv. 2012 Jan-Feb; 30(1):233-43. PMID: 21620943.
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    57. Fassan M, D'Arca D, Letko J, Vecchione A, Gardiman MP, McCue P, Wildemore B, Rugge M, Shupp-Byrne D, Gomella LG, Morrione A, Iozzo RV, Baffa R. Mitostatin is down-regulated in human prostate cancer and suppresses the invasive phenotype of prostate cancer cells. PLoS One. 2011; 6(5):e19771. PMID: 21573075.
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    58. DeAngelis T, Morrione A, Baserga R. Mutual interaction and reciprocal down-regulation between c-met and insulin receptor substrate-1. J Cell Physiol. 2010 Sep; 224(3):658-63. PMID: 20578241.
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    59. Metalli D, Lovat F, Tripodi F, Genua M, Xu SQ, Spinelli M, Alberghina L, Vanoni M, Baffa R, Gomella LG, Iozzo RV, Morrione A. The insulin-like growth factor receptor I promotes motility and invasion of bladder cancer cells through Akt- and mitogen-activated protein kinase-dependent activation of paxillin. Am J Pathol. 2010 Jun; 176(6):2997-3006. PMID: 20395438.
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    60. Lovat F, Bitto A, Xu SQ, Fassan M, Goldoni S, Metalli D, Wubah V, McCue P, Serrero G, Gomella LG, Baffa R, Iozzo RV, Morrione A. Proepithelin is an autocrine growth factor for bladder cancer. Carcinogenesis. 2009 May; 30(5):861-8. PMID: 19237611.
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    61. Monami G, Emiliozzi V, Bitto A, Lovat F, Xu SQ, Goldoni S, Fassan M, Serrero G, Gomella LG, Baffa R, Iozzo RV, Morrione A. Proepithelin regulates prostate cancer cell biology by promoting cell growth, migration, and anchorage-independent growth. Am J Pathol. 2009 Mar; 174(3):1037-47. PMID: 19179604.
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    62. Vecchione A, Fassan M, Anesti V, Morrione A, Goldoni S, Baldassarre G, Byrne D, D'Arca D, Palazzo JP, Lloyd J, Scorrano L, Gomella LG, Iozzo RV, Baffa R. MITOSTATIN, a putative tumor suppressor on chromosome 12q24.1, is downregulated in human bladder and breast cancer. Oncogene. 2009 Jan 15; 28(2):257-69. PMID: 18931701.
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    63. Monami G, Emiliozzi V, Morrione A. Grb10/Nedd4-mediated multiubiquitination of the insulin-like growth factor receptor regulates receptor internalization. J Cell Physiol. 2008 Aug; 216(2):426-37. PMID: 18286479.
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    64. Monami G, Gonzalez EM, Hellman M, Gomella LG, Baffa R, Iozzo RV, Morrione A. Proepithelin promotes migration and invasion of 5637 bladder cancer cells through the activation of ERK1/2 and the formation of a paxillin/FAK/ERK complex. Cancer Res. 2006 Jul 15; 66(14):7103-10. PMID: 16849556.
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    65. Ren SY, Bolton E, Mohi MG, Morrione A, Neel BG, Skorski T. Phosphatidylinositol 3-kinase p85{alpha} subunit-dependent interaction with BCR/ABL-related fusion tyrosine kinases: molecular mechanisms and biological consequences. Mol Cell Biol. 2005 Sep; 25(18):8001-8. PMID: 16135792.
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    66. Baldassarre G, Belletti B, Nicoloso MS, Schiappacassi M, Vecchione A, Spessotto P, Morrione A, Canzonieri V, Colombatti A. p27(Kip1)-stathmin interaction influences sarcoma cell migration and invasion. Cancer Cell. 2005 Jan; 7(1):51-63. PMID: 15652749.
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    67. Morrione A. Grb10 adapter protein as regulator of insulin-like growth factor receptor signaling. J Cell Physiol. 2003 Dec; 197(3):307-11. PMID: 14566960.
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    68. Vecchione A, Marchese A, Henry P, Rotin D, Morrione A. The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor. Mol Cell Biol. 2003 May; 23(9):3363-72. PMID: 12697834.
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    69. Klejman A, Rushen L, Morrione A, Slupianek A, Skorski T. Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571. Oncogene. 2002 Aug 29; 21(38):5868-76. PMID: 12185586.
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    70. Belletti B, Drakas R, Morrione A, Tu X, Prisco M, Yuan T, Casaburi I, Baserga R. Regulation of Id1 protein expression in mouse embryo fibroblasts by the type 1 insulin-like growth factor receptor. Exp Cell Res. 2002 Jul 1; 277(1):107-18. PMID: 12061821.
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    71. Morrione A, Navarro M, Romano G, Dews M, Reiss K, Valentinis B, Belletti B, Baserga R. The role of the insulin receptor substrate-1 in the differentiation of rat hippocampal neuronal cells. Oncogene. 2001 Aug 09; 20(35):4842-52. PMID: 11521195.
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    72. Peruzzi F, Prisco M, Morrione A, Valentinis B, Baserga R. Anti-apoptotic signaling of the insulin-like growth factor-I receptor through mitochondrial translocation of c-Raf and Nedd4. J Biol Chem. 2001 Jul 13; 276(28):25990-6. PMID: 11352919.
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    73. Slupianek A, Nieborowska-Skorska M, Hoser G, Morrione A, Majewski M, Xue L, Morris SW, Wasik MA, Skorski T. Role of phosphatidylinositol 3-kinase-Akt pathway in nucleophosmin/anaplastic lymphoma kinase-mediated lymphomagenesis. Cancer Res. 2001 Mar 01; 61(5):2194-9. PMID: 11280786.
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    74. Belletti B, Prisco M, Morrione A, Valentinis B, Navarro M, Baserga R. Regulation of Id2 gene expression by the insulin-like growth factor I receptor requires signaling by phosphatidylinositol 3-kinase. J Biol Chem. 2001 Apr 27; 276(17):13867-74. PMID: 11278691.
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    75. Valentinis B, Navarro M, Zanocco-Marani T, Edmonds P, McCormick J, Morrione A, Sacchi A, Romano G, Reiss K, Baserga R. Insulin receptor substrate-1, p70S6K, and cell size in transformation and differentiation of hemopoietic cells. J Biol Chem. 2000 Aug 18; 275(33):25451-9. PMID: 10846175.
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    76. Reiss K, Wang JY, Romano G, Furnari FB, Cavenee WK, Morrione A, Tu X, Baserga R. IGF-I receptor signaling in a prostatic cancer cell line with a PTEN mutation. Oncogene. 2000 May 18; 19(22):2687-94. PMID: 10851068.
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    77. Morrione A, Romano G, Navarro M, Reiss K, Valentinis B, Dews M, Eves E, Rosner MR, Baserga R. Insulin-like growth factor I receptor signaling in differentiation of neuronal H19-7 cells. Cancer Res. 2000 Apr 15; 60(8):2263-72. PMID: 10786694.
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    78. Dews M, Prisco M, Peruzzi F, Romano G, Morrione A, Baserga R. Domains of the insulin-like growth factor I receptor required for the activation of extracellular signal-regulated kinases. Endocrinology. 2000 Apr; 141(4):1289-300. PMID: 10746631.
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    79. Morrione A. Grb10 proteins in insulin-like growth factor and insulin receptor signaling (review). Int J Mol Med. 2000 Feb; 5(2):151-4. PMID: 10639593.
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    80. Reiss K, Yumet G, Shan S, Huang Z, Alnemri E, Srinivasula SM, Wang JY, Morrione A, Baserga R. Synthetic peptide sequence from the C-terminus of the insulin-like growth factor-I receptor that induces apoptosis and inhibition of tumor growth. J Cell Physiol. 1999 Oct; 181(1):124-35. PMID: 10457360.
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    81. Morrione A, Plant P, Valentinis B, Staub O, Kumar S, Rotin D, Baserga R. mGrb10 interacts with Nedd4. J Biol Chem. 1999 Aug 20; 274(34):24094-9. PMID: 10446181.
      Citations:    
    82. Valentinis B, Romano G, Peruzzi F, Morrione A, Prisco M, Soddu S, Cristofanelli B, Sacchi A, Baserga R. Growth and differentiation signals by the insulin-like growth factor 1 receptor in hemopoietic cells are mediated through different pathways. J Biol Chem. 1999 Apr 30; 274(18):12423-30. PMID: 10212216.
      Citations:    
    83. Valentinis B, Morrione A, Peruzzi F, Prisco M, Reiss K, Baserga R. Anti-apoptotic signaling of the IGF-I receptor in fibroblasts following loss of matrix adhesion. Oncogene. 1999 Mar 11; 18(10):1827-36. PMID: 10086337.
      Citations:    
    84. Baserga R, Morrione A. Differentiation and malignant transformation: two roads diverged in a wood. J Cell Biochem. 1999; Suppl 32-33:68-75. PMID: 10629105.
      Citations:    
    85. Morrione A, Valentinis B, Resnicoff M, Xu Sq, Baserga R. The role of mGrb10alpha in insulin-like growth factor I-mediated growth. J Biol Chem. 1997 Oct 17; 272(42):26382-7. PMID: 9334212.
      Citations:    
    86. Valentinis B, Morrione A, Taylor SJ, Baserga R. Insulin-like growth factor I receptor signaling in transformation by src oncogenes. Mol Cell Biol. 1997 Jul; 17(7):3744-54. PMID: 9199308.
      Citations:    
    87. Morrione A, Valentinis B, Xu SQ, Yumet G, Louvi A, Efstratiadis A, Baserga R. Insulin-like growth factor II stimulates cell proliferation through the insulin receptor. Proc Natl Acad Sci U S A. 1997 Apr 15; 94(8):3777-82. PMID: 9108054.
      Citations:    
    88. Venturini M, Morrione A, Pisarra P, Martegani E, Vanoni M. In Saccharomyces cerevisiae a short amino acid sequence facilitates excretion in the growth medium of periplasmic proteins. Mol Microbiol. 1997 Mar; 23(5):997-1007. PMID: 9076736.
      Citations:    
    89. Morrione A, Valentinis B, Li S, Ooi JY, Margolis B, Baserga R. Grb10: A new substrate of the insulin-like growth factor I receptor. Cancer Res. 1996 Jul 15; 56(14):3165-7. PMID: 8764099.
      Citations:    
    90. Hongo A, D'Ambrosio C, Miura M, Morrione A, Baserga R. Mutational analysis of the mitogenic and transforming activities of the insulin-like growth factor I receptor. Oncogene. 1996 Mar 21; 12(6):1231-8. PMID: 8649825.
      Citations:    
    91. Morrione A, DeAngelis T, Baserga R. The GC factor regulates the expression of the insulin-like growth factor-I receptor. Cell Prolif. 1995 Dec; 28(12):659-71. PMID: 8634373.
      Citations:    
    92. Morrione A, DeAngelis T, Baserga R. Failure of the bovine papillomavirus to transform mouse embryo fibroblasts with a targeted disruption of the insulin-like growth factor I receptor genes. J Virol. 1995 Sep; 69(9):5300-3. PMID: 7636972.
      Citations:    
    93. D'Ambrosio C, Keller SR, Morrione A, Lienhard GE, Baserga R, Surmacz E. Transforming potential of the insulin receptor substrate 1. Cell Growth Differ. 1995 May; 6(5):557-62. PMID: 7647039.
      Citations:    
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