Andrea Morrione

TitleAdjunct Faculty
InstitutionThomas Jefferson University
DepartmentJefferson College of Life Scie
Address1020 Locust St.
Philadelphia PA 19107
vCardDownload vCard

    Collapse Overview 
    Collapse overview
    Cell signaling
    cell transformation
    bladder cancer
    growth factors and growth factor receptors

    Collapse Research 
    Collapse research activities and funding
    K01DK002896     (MORRIONE, ANDREA C)Sep 1, 2000 - Aug 31, 2003
    NIH
    ROLE OF MGRB10 IN IGF-I INDUCED SIGNALING
    Role: Principal Investigator

    R01DK068419     (MORRIONE, ANDREA)May 1, 2005 - Mar 31, 2011
    NIH
    Proepithelin Signaling in Urothelial Cells
    Role: Principal Investigator

    R01CA164462     (IOZZO, RENATO V.)Sep 1, 2012 - Jun 30, 2018
    NIH
    Progranulin signaling in bladder cancer
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mancarella C, Morrione A, Scotlandi K. Novel Regulators of the IGF System in Cancer. Biomolecules. 2021 02 12; 11(2). PMID: 33673232.
      Citations:    
    2. Mancarella C, Caldoni G, Ribolsi I, Parra A, Manara MC, Mercurio AM, Morrione A, Scotlandi K. Insulin-Like Growth Factor 2 mRNA-Binding Protein 3 Modulates Aggressiveness of Ewing Sarcoma by Regulating the CD164-CXCR4 Axis. Front Oncol. 2020; 10:994. PMID: 32719743.
      Citations:    
    3. Buraschi S, Neill T, Xu SQ, Palladino C, Belfiore A, Iozzo RV, Morrione A. Progranulin/EphA2 axis: A novel oncogenic mechanism in bladder cancer. Matrix Biol. 2020 May 15. PMID: 32417448.
      Citations:    
    4. Buraschi S, Morcavallo A, Neill T, Stefanello M, Palladino C, Xu SQ, Belfiore A, Iozzo RV, Morrione A. Discoidin Domain Receptor 1 functionally interacts with the IGF-I system in bladder cancer. Matrix Biol Plus. 2020 May; 6-7:100022. PMID: 33543020.
      Citations:    
    5. Vella V, Nicolosi ML, Giuliano M, Morrione A, Malaguarnera R, Belfiore A. Insulin Receptor Isoform A Modulates Metabolic Reprogramming of Breast Cancer Cells in Response to IGF2 and Insulin Stimulation. Cells. 2019 Sep 01; 8(9). PMID: 31480557.
      Citations:    
    6. Vella V, Malaguarnera R, Nicolosi ML, Morrione A, Belfiore A. Insulin/IGF signaling and discoidin domain receptors: An emerging functional connection. Biochim Biophys Acta Mol Cell Res. 2019 Aug 05; 118522. PMID: 31394114.
      Citations:    
    7. Vella V, Nicolosi ML, Cantafio P, Massimino M, Lappano R, Vigneri P, Ciuni R, Gangemi P, Morrione A, Malaguarnera R, Belfiore A. DDR1 regulates thyroid cancer cell differentiation via IGF-2/IR-A autocrine signaling loop. Endocr Relat Cancer. 2018 Aug 18. PMID: 30121624.
      Citations:    
    8. Belfiore A, Malaguarnera R, Nicolosi ML, Lappano R, Ragusa M, Morrione A, Vella V. A novel functional crosstalk between DDR1 and the IGF axis and its relevance for breast cancer. Cell Adh Migr. 2018 Mar 23; 1-10. PMID: 29486622.
      Citations:    
    9. Xu SQ, Buraschi S, Tanimoto R, Stefanello M, Belfiore A, Iozzo RV, Morrione A. Analysis of Progranulin-Mediated Akt and MAPK Activation. Methods Mol Biol. 2018; 1806:121-130. PMID: 29956273.
      Citations:    
    10. Belfiore A, Malaguarnera R, Vella V, Lawrence MC, Sciacca L, Frasca F, Morrione A, Vigneri R. Insulin Receptor Isoforms in Physiology and Disease: An Updated View. Endocr Rev. 2017 Oct 01; 38(5):379-431. PMID: 28973479.
      Citations:    
    11. Vella V, Malaguarnera R, Luisa Nicolosi M, Palladino C, Spoleti C, Massimino M, Vigneri P, Purrello M, Ragusa M, Morrione A, Belfiore A. Discoidin domain receptor 1 modulates insulin receptor signaling and biological responses in breast cancer cells. Oncotarget. 2017 Jun 27; 8(26):43248-43270. PMID: 28591735.
      Citations:    
    12. Tanimoto R, Palladino C, Xu SQ, Buraschi S, Neill T, Gomella LG, Peiper SC, Belfiore A, Iozzo RV, Morrione A. The perlecan-interacting growth factor progranulin regulates ubiquitination, sorting, and lysosomal degradation of sortilin. Matrix Biol. 2017 Dec; 64:27-39. PMID: 28433812.
      Citations:    
    13. Neill T, Buraschi S, Goyal A, Sharpe C, Natkanski E, Schaefer L, Morrione A, Iozzo RV. EphA2 is a functional receptor for the growth factor progranulin. J Cell Biol. 2016 Dec 05; 215(5):687-703. PMID: 27903606.
      Citations:    
    14. Manara MC, Terracciano M, Mancarella C, Sciandra M, Guerzoni C, Pasello M, Grilli A, Zini N, Picci P, Colombo MP, Morrione A, Scotlandi K. CD99 triggering induces methuosis of Ewing sarcoma cells through IGF-1R/RAS/Rac1 signaling. Oncotarget. 2016 Nov 7. PMID: 27835596.
      Citations:    
    15. Tanimoto R, Lu KG, Xu SQ, Buraschi S, Belfiore A, Iozzo RV, Morrione A. Mechanisms of Progranulin Action and Regulation in Genitourinary Cancers. Front Endocrinol (Lausanne). 2016; 7:100. PMID: 27512385.
      Citations:    
    16. Buraschi S, Xu SQ, Stefanello M, Moskalev I, Morcavallo A, Genua M, Tanimoto R, Birbe R, Peiper SC, Gomella LG, Belfiore A, Black PC, Iozzo RV, Morrione A. Suppression of progranulin expression inhibits bladder cancer growth and sensitizes cancer cells to cisplatin. Oncotarget. 2016 Jun 28; 7(26):39980-39995. PMID: 27220888.
      Citations:    
    17. Matà R, Palladino C, Nicolosi ML, Lo Presti AR, Malaguarnera R, Ragusa M, Sciortino D, Morrione A, Maggiolini M, Vella V, Belfiore A. IGF-I induces upregulation of DDR1 collagen receptor in breast cancer cells by suppressing MIR-199a-5p through the PI3K/AKT pathway. Oncotarget. 2016 Feb 16; 7(7):7683-700. PMID: 26655502.
      Citations:    
    18. Malaguarnera R, Nicolosi ML, Sacco A, Morcavallo A, Vella V, Voci C, Spatuzza M, Xu SQ, Iozzo RV, Vigneri R, Morrione A, Belfiore A. Novel cross talk between IGF-IR and DDR1 regulates IGF-IR trafficking, signaling and biological responses. Oncotarget. 2015 Jun 30; 6(18):16084-105. PMID: 25840417.
      Citations:    
    19. Xu SQ, Buraschi S, Morcavallo A, Genua M, Shirao T, Peiper SC, Gomella LG, Birbe R, Belfiore A, Iozzo RV, Morrione A. A novel role for drebrin in regulating progranulin bioactivity in bladder cancer. Oncotarget. 2015 May 10; 6(13):10825-39. PMID: 25839164.
      Citations:    
    20. Tanimoto R, Morcavallo A, Terracciano M, Xu SQ, Stefanello M, Buraschi S, Lu KG, Bagley DH, Gomella LG, Scotlandi K, Belfiore A, Iozzo RV, Morrione A. Sortilin regulates progranulin action in castration-resistant prostate cancer cells. Endocrinology. 2015 Jan; 1(1):58-70. PMID: 25365768.
      Citations:    
    21. Morcavallo A, Stefanello M, Iozzo RV, Belfiore A, Morrione A. Ligand-mediated endocytosis and trafficking of the insulin-like growth factor receptor I and insulin receptor modulate receptor function. Front Endocrinol (Lausanne). 2014; 5:220. PMID: 25566192.
      Citations:    
    22. Malaguarnera R, Sacco A, Morcavallo A, Squatrito S, Migliaccio A, Morrione A, Maggiolini M, Belfiore A. Metformin Inhibits Androgen-Induced IGF-IR Up-Regulation in Prostate Cancer Cells by Disrupting Membrane-Initiated Androgen Signaling. Endocrinology. 2014 Apr; 155(4):1207-21. PMID: 24437490.
      Citations:    
    23. Morcavallo A, Buraschi S, Xu SQ, Belfiore A, Schaefer L, Iozzo RV, Morrione A. Decorin differentially modulates the activity of insulin receptor isoform A ligands. Matrix Biol. 2014 Apr; 35:82-90. PMID: 24389353.
      Citations:    
    24. Deangelis T, Quong A, Morrione A, Baserga R. Growth of v-src-transformed cells in serum-free medium through the induction of growth factors. J Cell Physiol. 2013 Jul; 228(7):1482-6. PMID: 23254450.
      Citations:    
    25. Goel HL, Sayeed A, Breen M, Zarif MJ, Garlick DS, Leav I, Davis RJ, Fitzgerald TJ, Morrione A, Hsieh CC, Liu Q, Dicker AP, Altieri DC, Languino LR. ß1 integrins mediate resistance to ionizing radiation in vivo by inhibiting c-Jun amino terminal kinase 1. J Cell Physiol. 2013 Jul; 228(7):1601-9. PMID: 23359252.
      Citations:    
    26. Morrione A, Neill T, Iozzo RV. Dichotomy of decorin activity on the insulin-like growth factor-I system. FEBS J. 2013 May; 280(10):2138-49. PMID: 23351020.
      Citations:    
    27. Genua M, Xu SQ, Buraschi S, Peiper SC, Gomella LG, Belfiore A, Iozzo RV, Morrione A. Proline-rich tyrosine kinase 2 (Pyk2) regulates IGF-I-induced cell motility and invasion of urothelial carcinoma cells. PLoS One. 2012; 7(6):e40148. PMID: 22859931.
      Citations:    
    28. Morcavallo A, Genua M, Palummo A, Kletvikova E, Jiracek J, Brzozowski AM, Iozzo RV, Belfiore A, Morrione A. Insulin and insulin-like growth factor II differentially regulate endocytic sorting and stability of insulin receptor isoform A. J Biol Chem. 2012 Mar 30; 287(14):11422-36. PMID: 22318726.
      Citations:    
    29. Iozzo RV, Buraschi S, Genua M, Xu SQ, Solomides CC, Peiper SC, Gomella LG, Owens RC, Morrione A. Decorin antagonizes IGF receptor I (IGF-IR) function by interfering with IGF-IR activity and attenuating downstream signaling. J Biol Chem. 2011 Oct 7; 286(40):34712-21. PMID: 21840990.
      Citations:    
    30. Sacco E, Metalli D, Spinelli M, Manzoni R, Samalikova M, Grandori R, Morrione A, Traversa S, Alberghina L, Vanoni M. Novel RasGRF1-derived Tat-fused peptides inhibiting Ras-dependent proliferation and migration in mouse and human cancer cells. Biotechnol Adv. 2012 Jan-Feb; 30(1):233-43. PMID: 21620943.
      Citations:    
    31. Fassan M, D'Arca D, Letko J, Vecchione A, Gardiman MP, McCue P, Wildemore B, Rugge M, Shupp-Byrne D, Gomella LG, Morrione A, Iozzo RV, Baffa R. Mitostatin is down-regulated in human prostate cancer and suppresses the invasive phenotype of prostate cancer cells. PLoS One. 2011; 6(5):e19771. PMID: 21573075.
      Citations:    
    32. DeAngelis T, Morrione A, Baserga R. Mutual interaction and reciprocal down-regulation between c-met and insulin receptor substrate-1. J Cell Physiol. 2010 Sep; 224(3):658-63. PMID: 20578241.
      Citations:    
    33. Metalli D, Lovat F, Tripodi F, Genua M, Xu SQ, Spinelli M, Alberghina L, Vanoni M, Baffa R, Gomella LG, Iozzo RV, Morrione A. The insulin-like growth factor receptor I promotes motility and invasion of bladder cancer cells through Akt- and mitogen-activated protein kinase-dependent activation of paxillin. Am J Pathol. 2010 Jun; 176(6):2997-3006. PMID: 20395438.
      Citations:    
    34. Lovat F, Bitto A, Xu SQ, Fassan M, Goldoni S, Metalli D, Wubah V, McCue P, Serrero G, Gomella LG, Baffa R, Iozzo RV, Morrione A. Proepithelin is an autocrine growth factor for bladder cancer. Carcinogenesis. 2009 May; 30(5):861-8. PMID: 19237611.
      Citations:    
    35. Monami G, Emiliozzi V, Bitto A, Lovat F, Xu SQ, Goldoni S, Fassan M, Serrero G, Gomella LG, Baffa R, Iozzo RV, Morrione A. Proepithelin regulates prostate cancer cell biology by promoting cell growth, migration, and anchorage-independent growth. Am J Pathol. 2009 Mar; 174(3):1037-47. PMID: 19179604.
      Citations:    
    36. Monami G, Emiliozzi V, Morrione A. Grb10/Nedd4-mediated multiubiquitination of the insulin-like growth factor receptor regulates receptor internalization. J Cell Physiol. 2008 Aug; 216(2):426-37. PMID: 18286479.
      Citations:    
    37. Monami G, Gonzalez EM, Hellman M, Gomella LG, Baffa R, Iozzo RV, Morrione A. Proepithelin promotes migration and invasion of 5637 bladder cancer cells through the activation of ERK1/2 and the formation of a paxillin/FAK/ERK complex. Cancer Res. 2006 Jul 15; 66(14):7103-10. PMID: 16849556.
      Citations:    
    38. Ren SY, Bolton E, Mohi MG, Morrione A, Neel BG, Skorski T. Phosphatidylinositol 3-kinase p85{alpha} subunit-dependent interaction with BCR/ABL-related fusion tyrosine kinases: molecular mechanisms and biological consequences. Mol Cell Biol. 2005 Sep; 25(18):8001-8. PMID: 16135792.
      Citations:    
    39. Baldassarre G, Belletti B, Nicoloso MS, Schiappacassi M, Vecchione A, Spessotto P, Morrione A, Canzonieri V, Colombatti A. p27(Kip1)-stathmin interaction influences sarcoma cell migration and invasion. Cancer Cell. 2005 Jan; 7(1):51-63. PMID: 15652749.
      Citations:    
    40. Morrione A. Grb10 adapter protein as regulator of insulin-like growth factor receptor signaling. J Cell Physiol. 2003 Dec; 197(3):307-11. PMID: 14566960.
      Citations:    
    41. Vecchione A, Marchese A, Henry P, Rotin D, Morrione A. The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor. Mol Cell Biol. 2003 May; 23(9):3363-72. PMID: 12697834.
      Citations:    
    42. Klejman A, Rushen L, Morrione A, Slupianek A, Skorski T. Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571. Oncogene. 2002 Aug 29; 21(38):5868-76. PMID: 12185586.
      Citations:    
    43. Belletti B, Drakas R, Morrione A, Tu X, Prisco M, Yuan T, Casaburi I, Baserga R. Regulation of Id1 protein expression in mouse embryo fibroblasts by the type 1 insulin-like growth factor receptor. Exp Cell Res. 2002 Jul 1; 277(1):107-18. PMID: 12061821.
      Citations:    
    Morrione's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (167)
    Explore
    _
    Co-Authors (9)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _
    Physical Neighbors
    _