Thomas Jefferson University

Alexander Mazo

TitleProfessor
InstitutionThomas Jefferson University
DepartmentBiochem & Molecular Biology
Address1020 Locust St.
Philadelphia PA 19107
Phone215-503-4785
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    R01GM075141     (MAZO, ALEXANDER M)Aug 1, 2005 - Apr 30, 2022
    NIH
    Transcriptional Regulation by Epigenetic Factors
    Role: Principal Investigator
    R01HL127895     (CALABRETTA, BRUNO)Mar 1, 2016 - Feb 28, 2021
    NIH
    The role of chromatin structure in differentiation of hematopoietic stem cells
    Role: Co-Principal Investigator
    R01AI125650     (MAZO, ALEXANDER M)Feb 3, 2017 - Jan 31, 2022
    NIH
    The Role of the De-condensed Structure of Nascent Chromatin During T Cell Differentiation
    Role: Principal Investigator
    R01EY026159     (WALKER, JANICE LYNN)Apr 1, 2017 - Mar 31, 2021
    NIH
    Structure of post-replicative chromatin during cell reprogramming in fibrotic disease
    Role: Co-Principal Investigator
    R01CA268899     (CALABRETTA, BRUNO)Jan 1, 2022 - Dec 31, 2026
    NIH
    A novel strategy for transcriptional reprogramming of lymphoid leukemia cells
    Role: Co-Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Fenstermaker TK, Petruk S, Mazo A. An emerging paradigm in epigenetic marking: coordination of transcription and replication. Transcription. 2024 Feb-Apr; 15(1-2):22-37. PMID: 38378467.
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    2. Fenstermaker TK, Petruk S, Kovermann SK, Brock HW, Mazo A. RNA polymerase II associates with active genes during DNA replication. Nature. 2023 08; 620(7973):426-433. PMID: 37468626.
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    3. Basta MD, Petruk S, Mazo A, Walker JL. Fibrosis-the tale of H3K27 histone methyltransferases and demethylases. Front Cell Dev Biol. 2023; 11:1193344. PMID: 37476157.
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    4. Basta MD, Petruk S, Summer R, Rosenbloom J, Wermuth PJ, Macarak E, Levin AV, Mazo A, Walker JL. Changes in nascent chromatin structure regulate activation of the pro-fibrotic transcriptome and myofibroblast emergence in organ fibrosis. iScience. 2023 May 19; 26(5):106570. PMID: 37250334.
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    5. Porazzi P, Petruk S, Pagliaroli L, De Dominici M, Deming D, Puccetti MV, Kushinsky S, Kumar G, Minieri V, Barbieri E, Deliard S, Grande A, Trizzino M, Gardini A, Canaani E, Palmisiano N, Porcu P, Ertel A, Fortina P, Eischen CM, Mazo A, Calabretta B. Targeting Chemotherapy to Decondensed H3K27me3-Marked Chromatin of AML Cells Enhances Leukemia Suppression. Cancer Res. 2022 02 01; 82(3):458-471. PMID: 34903608.
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    6. De Dominici M, Porazzi P, Xiao Y, Chao A, Tang HY, Kumar G, Fortina P, Spinelli O, Rambaldi A, Peterson LF, Petruk S, Barletta C, Mazo A, Cingolani G, Salvino JM, Calabretta B. Selective inhibition of Ph-positive ALL cell growth through kinase-dependent and -independent effects by CDK6-specific PROTACs. Blood. 2020 04 30; 135(18):1560-1573. PMID: 32040545.
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    7. Kohzaki H, Asano M, Murakami Y, Mazo A. Epigenetic regulation affects gene amplification in Drosophila development. Front Biosci (Landmark Ed). 2020 01 01; 25(4):632-645. PMID: 31585908.
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    8. Xiao G, Lundine D, Annor GK, Canar J, Ellison V, Polotskaia A, Donabedian PL, Reiner T, Khramtsova GF, Olopade OI, Mazo A, Bargonetti J. Gain-of-Function Mutant p53 R273H Interacts with Replicating DNA and PARP1 in Breast Cancer. Cancer Res. 2020 02 01; 80(3):394-405. PMID: 31776133.
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    9. Fenstermaker TK, Sun G, Mazo A, Petruk S. A Proximity Ligation-Based Method to Detect RNA-DNA Association. Methods Mol Biol. 2019; 2008:121-129. PMID: 31124093.
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    10. Akishina AA, Vorontsova JE, Cherezov RO, Mertsalov IB, Zatsepina OG, Slezinger MS, Panin VM, Petruk S, Enikolopov GN, Mazo A, Simonova OB, Kuzin BA. Xenobiotic-induced activation of human aryl hydrocarbon receptor target genes in Drosophila is mediated by the epigenetic chromatin modifiers. Oncotarget. 2017 Nov 28; 8(61):102934-102947. PMID: 29262535.
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    11. Li T, Hodgson JW, Petruk S, Mazo A, Brock HW. Additional sex combs interacts with enhancer of zeste and trithorax and modulates levels of trimethylation on histone H3K4 and H3K27 during transcription of hsp70. Epigenetics Chromatin. 2017 09 19; 10(1):43. PMID: 28927461.
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    12. Petruk S, Cai J, Sussman R, Sun G, Kovermann SK, Mariani SA, Calabretta B, McMahon SB, Brock HW, Iacovitti L, Mazo A. Delayed Accumulation of H3K27me3 on Nascent DNA Is Essential for Recruitment of Transcription Factors at Early Stages of Stem Cell Differentiation. Mol Cell. 2017 Apr 20; 66(2):247-257.e5. PMID: 28410996.
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    13. Petruk S, Mariani SA, De Dominici M, Porazzi P, Minieri V, Cai J, Iacovitti L, Flomenberg N, Calabretta B, Mazo A. Structure of Nascent Chromatin Is Essential for Hematopoietic Lineage Specification. Cell Rep. 2017 04 11; 19(2):295-306. PMID: 28402853.
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    14. L Black K, Petruk S, Fenstermaker TK, Hodgson JW, Caplan JL, Brock HW, Mazo A. Chromatin proteins and RNA are associated with DNA during all phases of mitosis. Cell Discov. 2016; 2:16038. PMID: 27807477.
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    15. Petruk S, Fenstermaker TK, Black KL, Brock HW, Mazo A. Detection of RNA-DNA association by a proximity ligation-based method. Sci Rep. 2016 06 03; 6:27313. PMID: 27256324.
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    16. Petruk S, Black KL, Kovermann SK, Brock HW, Mazo A. Stepwise histone modifications are mediated by multiple enzymes that rapidly associate with nascent DNA during replication. Nat Commun. 2013; 4:2841. PMID: 24276476.
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    17. Carbonell A, Mazo A, Serras F, Corominas M. Ash2 acts as an ecdysone receptor coactivator by stabilizing the histone methyltransferase Trr. Mol Biol Cell. 2013 Feb; 24(3):361-72. PMID: 23197473.
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    18. Petruk S, Sedkov Y, Johnston DM, Hodgson JW, Black KL, Kovermann SK, Beck S, Canaani E, Brock HW, Mazo A. TrxG and PcG proteins but not methylated histones remain associated with DNA through replication. Cell. 2012 Aug 31; 150(5):922-33. PMID: 22921915.
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    19. Johnston DM, Sedkov Y, Petruk S, Riley KM, Fujioka M, Jaynes JB, Mazo A. Ecdysone- and NO-mediated gene regulation by competing EcR/Usp and E75A nuclear receptors during Drosophila development. Mol Cell. 2011 Oct 07; 44(1):51-61. PMID: 21981918.
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    20. Brock HW, Hodgson JW, Petruk S, Mazo A. Regulatory noncoding RNAs at Hox loci. Biochem Cell Biol. 2009 Feb; 87(1):27-34. PMID: 19234521.
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    21. Petruk S, Smith ST, Sedkov Y, Mazo A. Association of trxG and PcG proteins with the bxd maintenance element depends on transcriptional activity. Development. 2008 Aug; 135(14):2383-90. PMID: 18550707.
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    22. Mazo A, Hodgson JW, Petruk S, Sedkov Y, Brock HW. Transcriptional interference: an unexpected layer of complexity in gene regulation. J Cell Sci. 2007 Aug 15; 120(Pt 16):2755-61. PMID: 17690303.
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    23. Petruk S, Sedkov Y, Brock HW, Mazo A. A model for initiation of mosaic HOX gene expression patterns by non-coding RNAs in early embryos. RNA Biol. 2007 Jan-Mar; 4(1):1-6. PMID: 17568198.
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    24. Petruk S, Sedkov Y, Riley KM, Hodgson J, Schweisguth F, Hirose S, Jaynes JB, Brock HW, Mazo A. Transcription of bxd noncoding RNAs promoted by trithorax represses Ubx in cis by transcriptional interference. Cell. 2006 Dec 15; 127(6):1209-21. PMID: 17174895.
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    25. Krajewski WA, Nakamura T, Mazo A, Canaani E. A motif within SET-domain proteins binds single-stranded nucleic acids and transcribed and supercoiled DNAs and can interfere with assembly of nucleosomes. Mol Cell Biol. 2005 Mar; 25(5):1891-9. PMID: 15713643.
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    26. Smith ST, Petruk S, Sedkov Y, Cho E, Tillib S, Canaani E, Mazo A. Modulation of heat shock gene expression by the TAC1 chromatin-modifying complex. Nat Cell Biol. 2004 Feb; 6(2):162-7. PMID: 14730313.
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    27. Petruk S, Sedkov Y, Smith ST, Krajewski W, Nakamura T, Canaani E, Croce CM, Mazo A. Purification and biochemical properties of the Drosophila TAC1 complex. Methods Enzymol. 2004; 377:255-66. PMID: 14979030.
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    28. Sedkov Y, Cho E, Petruk S, Cherbas L, Smith ST, Jones RS, Cherbas P, Canaani E, Jaynes JB, Mazo A. Methylation at lysine 4 of histone H3 in ecdysone-dependent development of Drosophila. Nature. 2003 Nov 06; 426(6962):78-83. PMID: 14603321.
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    29. Nakamura T, Mori T, Tada S, Krajewski W, Rozovskaia T, Wassell R, Dubois G, Mazo A, Croce CM, Canaani E. ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation. Mol Cell. 2002 Nov; 10(5):1119-28. PMID: 12453419.
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    30. Petruk S, Sedkov Y, Smith S, Tillib S, Kraevski V, Nakamura T, Canaani E, Croce CM, Mazo A. Trithorax and dCBP acting in a complex to maintain expression of a homeotic gene. Science. 2001 Nov 09; 294(5545):1331-4. PMID: 11701926.
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    31. Nakamura T, Blechman J, Tada S, Rozovskaia T, Itoyama T, Bullrich F, Mazo A, Croce CM, Geiger B, Canaani E. huASH1 protein, a putative transcription factor encoded by a human homologue of the Drosophila ash1 gene, localizes to both nuclei and cell-cell tight junctions. Proc Natl Acad Sci U S A. 2000 Jun 20; 97(13):7284-9. PMID: 10860993.
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    32. Tillib S, Petruk S, Sedkov Y, Kuzin A, Fujioka M, Goto T, Mazo A. Trithorax- and Polycomb-group response elements within an Ultrabithorax transcription maintenance unit consist of closely situated but separable sequences. Mol Cell Biol. 1999 Jul; 19(7):5189-202. PMID: 10373568.
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    33. Sedkov Y, Benes JJ, Berger JR, Riker KM, Tillib S, Jones RS, Mazo A. Molecular genetic analysis of the Drosophila trithorax-related gene which encodes a novel SET domain protein. Mech Dev. 1999 Apr; 82(1-2):171-9. PMID: 10354481.
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    34. Pekarsky Y, Campiglio M, Siprashvili Z, Druck T, Sedkov Y, Tillib S, Draganescu A, Wermuth P, Rothman JH, Huebner K, Buchberg AM, Mazo A, Brenner C, Croce CM. Nitrilase and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegans. Proc Natl Acad Sci U S A. 1998 Jul 21; 95(15):8744-9. PMID: 9671749.
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    35. Arakawa H, Nakamura T, Zhadanov AB, Fidanza V, Yano T, Bullrich F, Shimizu M, Blechman J, Mazo A, Canaani E, Croce CM. Identification and characterization of the ARP1 gene, a target for the human acute leukemia ALL1 gene. Proc Natl Acad Sci U S A. 1998 Apr 14; 95(8):4573-8. PMID: 9539779.
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    36. Prasad R, Zhadanov AB, Sedkov Y, Bullrich F, Druck T, Rallapalli R, Yano T, Alder H, Croce CM, Huebner K, Mazo A, Canaani E. Structure and expression pattern of human ALR, a novel gene with strong homology to ALL-1 involved in acute leukemia and to Drosophila trithorax. Oncogene. 1997 Jul 31; 15(5):549-60. PMID: 9247308.
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    37. Fujioka M, Yusibova GL, Sackerson CM, Tillib S, Mazo A, Satake M, Goto T. Runt domain partner proteins enhance DNA binding and transcriptional repression in cultured Drosophila cells. Genes Cells. 1996 Aug; 1(8):741-54. PMID: 9077443.
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    38. Tillib S, Sedkov Y, Mizrokhi L, Mazo A. Conservation of structure and expression of the trithorax gene between Drosophila virilis and Drosophila melanogaster. Mech Dev. 1995 Sep; 53(1):113-22. PMID: 8555104.
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    39. Kuzin B, Tillib S, Sedkov Y, Mizrokhi L, Mazo A. The Drosophila trithorax gene encodes a chromosomal protein and directly regulates the region-specific homeotic gene fork head. Genes Dev. 1994 Oct 15; 8(20):2478-90. PMID: 7958911.
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    40. Sedkov Y, Tillib S, Mizrokhi L, Mazo A. The bithorax complex is regulated by trithorax earlier during Drosophila embryogenesis than is the Antennapedia complex, correlating with a bithorax-like expression pattern of distinct early trithorax transcripts. Development. 1994 Jul; 120(7):1907-17. PMID: 7924996.
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    41. Mizrokhi LJ, Mazo AM. Cloning and analysis of the mobile element gypsy from D. virilis. Nucleic Acids Res. 1991 Feb 25; 19(4):913-6. PMID: 1708127.
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    42. Mizrokhi LJ, Mazo AM. Evidence for horizontal transmission of the mobile element jockey between distant Drosophila species. Proc Natl Acad Sci U S A. 1990 Dec; 87(23):9216-20. PMID: 1701254.
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    43. Mazo AM, Huang DH, Mozer BA, Dawid IB. The trithorax gene, a trans-acting regulator of the bithorax complex in Drosophila, encodes a protein with zinc-binding domains. Proc Natl Acad Sci U S A. 1990 Mar; 87(6):2112-6. PMID: 2107543.
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    44. Lamand? N, Mazo AM, Lucas M, Montarras D, Pinset C, Gros F, Legault-Demare L, Lazar M. Murine muscle-specific enolase: cDNA cloning, sequence, and developmental expression. Proc Natl Acad Sci U S A. 1989 Jun; 86(12):4445-9. PMID: 2734297.
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    45. Mizrokhi LIu, Mazo AM, Karavanov AA, Sedkov IuA, Krichevskaia AA. [Interaction of products of su(Hw) and su(f) genes with MDG4 region regulating its transcription suppresses mutations in Drosophila caused by insertion of this gene]. Genetika. 1989 May; 25(5):784-98. PMID: 2545520.
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    46. Mazo AM, Mizrokhi LJ, Karavanov AA, Sedkov YA, Krichevskaja AA, Ilyin YV. Suppression in Drosophila: su(Hw) and su(f) gene products interact with a region of gypsy (mdg4) regulating its transcriptional activity. EMBO J. 1989 Mar; 8(3):903-11. PMID: 2498087.
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    47. Dzhumgaliev EB, Mazo AM, Baev AA, Gorelova TV, Arkhipova IR. [Structure of long terminal repeats of transcriptionally active and inactive copies of the mobile dispersed gene MDG3 in Drosophila melanogaster]. Genetika. 1986 Mar; 22(3):368-77. PMID: 3007285.
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    48. Mazo AM, Arkhipova IR, Cherkasova VA, Gorelova TV, Shuppe NG. [Fine structure of long terminal repeats and stages of reverse transcription of mobile dispersed genes in Drosophila]. Genetika. 1986 Mar; 22(3):378-89. PMID: 2420684.
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    49. Arkhipova IR, Mazo AM, Cherkasova VA, Gorelova TV, Schuppe NG, Llyin YV. The steps of reverse transcription of Drosophila mobile dispersed genetic elements and U3-R-U5 structure of their LTRs. Cell. 1986 Feb 28; 44(4):555-63. PMID: 2418981.
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    50. Kupriianova NS, Serenkova TI, Mazo AM, Timofeeva MIa. [Study of a cloned ribosomal operon region coding for 5.8S rRNA in the loach Misgurnus fossilis L]. Mol Biol (Mosk). 1984 Sep-Oct; 18(5):1385-95. PMID: 6095030.
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    51. Pusyriov AT, Mazo AM, Minchenko AG, Avdonina TA. Transcriptional mapping of the rat liver mitochondrial genome. Gene. 1983 Sep; 24(1):115-24. PMID: 6628998.
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