Thomas Jefferson University

Allyn Menko

TitleProfessor & Vice Chair
InstitutionThomas Jefferson University
DepartmentAnatomy
Address1020 Locust St.
Philadelphia PA 19107
Phone215-503-2166
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Le PM, Pal-Ghosh S, Stepp MA, Menko AS. Shared Phenotypes of Immune Cells Recruited to the Cornea and the Surface of the Lens in Response to Formation of Corneal Erosions. Am J Pathol. 2025 May; 195(5):960-981. PMID: 39889825.
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    2. Gheyas RN, Williams RC, Ryan KA, Menko AS. The link of FOXO1 and FOXO4 transcription factors to development of the lens. Dev Dyn. 2025 Jul; 254(7):829-852. PMID: 39797725.
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    3. Le PM, Mattapallil MJ, Caspi RR, Stepp MA, Menko AS. Immunoregulatory Properties of Immune Cells that Associate with the Lens Capsule Surface during Acute and Resolution Phases of Experimental Autoimmune Uveitis. Am J Pathol. 2024 Nov; 194(11):2194-2211. PMID: 39159867.
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    4. DeDreu J, Basta MD, Walker JL, Menko AS. Immune Responses Induced at One Hour Post Cataract Surgery Wounding of the Chick Lens. Biomolecules. 2023 11 04; 13(11). PMID: 38002297.
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    5. Gheyas R, Menko AS. The involvement of caspases in the process of nuclear removal during lens fiber cell differentiation. Cell Death Discov. 2023 Oct 21; 9(1):386. PMID: 37865680.
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    6. Gheyas R, Menko AS. Examining PI3K-signaling-dependent regulation of?lens organelle free zone formation via immunolocalization and immunoblotting in chick embryos. STAR Protoc. 2023 12 15; 4(4):102569. PMID: 37713308.
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    7. Le PM, Pal-Ghosh S, Menko AS, Stepp MA. Immune Cells Localize to Sites of Corneal Erosions in C57BL/6 Mice. Biomolecules. 2023 06 29; 13(7). PMID: 37509096.
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    8. DeDreu J, Le PM, Menko AS. The ciliary zonules provide a pathway for immune cells to populate the avascular lens during eye development. Exp Biol Med (Maywood). 2022 12; 247(24):2251-2273. PMID: 36633170.
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    9. Basta MD, Menko AS, Walker JL. PI3K Isoform-Specific Regulation of Leader and Follower Cell Function for Collective Migration and Proliferation in Response to Injury. Cells. 2022 11 07; 11(21). PMID: 36359913.
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    10. Menko AS, Walker JL. The Pro-Fibrotic Response to Lens Injury Is Signaled in a PI3K Isoform-Specific Manner. Biomolecules. 2022 08 25; 12(9). PMID: 36139020.
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    11. Menko AS, Romisher A, Walker JL. The Pro-fibrotic Response of Mesenchymal Leader Cells to Lens Wounding Involves Hyaluronic Acid, Its Receptor RHAMM, and Vimentin. Front Cell Dev Biol. 2022; 10:862423. PMID: 35386200.
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    12. Gheyas R, Ortega-Alvarez R, Chauss D, Kantorow M, Menko AS. Suppression of PI3K signaling is linked to autophagy activation and the spatiotemporal induction of the lens organelle free zone. Exp Cell Res. 2022 03 15; 412(2):113043. PMID: 35101390.
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    13. DeDreu J, Pal-Ghosh S, Mattapallil MJ, Caspi RR, Stepp MA, Menko AS. Uveitis-mediated immune cell invasion through the extracellular matrix of the lens capsule. FASEB J. 2022 01; 36(1):e21995. PMID: 34874579.
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    14. Walker JL, Menko AS. Immune cells in lens injury repair and fibrosis. Exp Eye Res. 2021 08; 209:108664. PMID: 34126081.
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    15. Menko AS, DeDreu J, Logan CM, Paulson H, Levin AV, Walker JL. Resident immune cells of the avascular lens: Mediators of the injury and fibrotic response of the lens. FASEB J. 2021 04; 35(4):e21341. PMID: 33710665.
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    16. Walker JL, Wang W, Lin E, Romisher A, Bouchie MP, Bleaken B, Menko AS, Kukuruzinska MA. Specification of the patterning of a ductal tree during branching morphogenesis of the submandibular gland. Sci Rep. 2021 01 11; 11(1):330. PMID: 33432003.
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    17. DeDreu J, Walker JL, Menko AS. Dynamics of the lens basement membrane capsule and its interaction with connective tissue-like extracapsular matrix proteins. Matrix Biol. 2021 02; 96:18-46. PMID: 33383103.
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    18. DeDreu J, Bowen CJ, Logan CM, Pal-Ghosh S, Parlanti P, Stepp MA, Menko AS. An immune response to the avascular lens following wounding of the cornea involves ciliary zonule fibrils. FASEB J. 2020 07; 34(7):9316-9336. PMID: 32452112.
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    19. Logan CM, Menko AS. Microtubules: Evolving roles and critical cellular interactions. Exp Biol Med (Maywood). 2019 11; 244(15):1240-1254. PMID: 31387376.
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    20. Menko AS, Walker JL, Stepp MA. Fibrosis: Shared Lessons From the Lens and Cornea. Anat Rec (Hoboken). 2020 06; 303(6):1689-1702. PMID: 30768772.
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    21. Walker JL, Bleaken BM, Romisher AR, Alnwibit AA, Menko AS. In wound repair vimentin mediates the transition of mesenchymal leader cells to a myofibroblast phenotype. Mol Biol Cell. 2018 07 01; 29(13):1555-1570. PMID: 29718762.
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    22. Logan CM, Bowen CJ, Menko AS. Functional role for stable microtubules in lens fiber cell elongation. Exp Cell Res. 2018 01 15; 362(2):477-488. PMID: 29253534.
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    23. Logan CM, Bowen CJ, Menko AS. Induction of Immune Surveillance of the Dysmorphogenic Lens. Sci Rep. 2017 11 24; 7(1):16235. PMID: 29176738.
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    24. Logan CM, Rajakaruna S, Bowen C, Radice GL, Robinson ML, Menko AS. N-cadherin regulates signaling mechanisms required for lens fiber cell elongation and lens morphogenesis. Dev Biol. 2017 08 01; 428(1):118-134. PMID: 28552735.
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    25. Bleaken BM, Menko AS, Walker JL. Cells activated for wound repair have the potential to direct collective invasion of an epithelium. Mol Biol Cell. 2016 Feb 01; 27(3):451-65. PMID: 26658613.
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    26. Walker JL, Bleaken BM, Wolff IM, Menko AS. Establishment of a Clinically Relevant Ex Vivo Mock Cataract Surgery Model for Investigating Epithelial Wound Repair in a Native Microenvironment. J Vis Exp. 2015 Jun 05; (100):e52886. PMID: 26132117.
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    27. Chauss D, Basu S, Rajakaruna S, Ma Z, Gau V, Anastas S, Brennan LA, Hejtmancik JF, Menko AS, Kantorow M. Differentiation state-specific mitochondrial dynamic regulatory networks are revealed by global transcriptional analysis of the developing chicken lens. G3 (Bethesda). 2014 Jun 13; 4(8):1515-27. PMID: 24928582.
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    28. Basu S, Rajakaruna S, Reyes B, Van Bockstaele E, Menko AS. Suppression of MAPK/JNK-MTORC1 signaling leads to premature loss of organelles and nuclei by autophagy during terminal differentiation of lens fiber cells. Autophagy. 2014 Jul; 10(7):1193-211. PMID: 24813396.
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    29. Pal-Ghosh S, Pajoohesh-Ganji A, Menko AS, Oh HY, Tadvalkar G, Saban DR, Stepp MA. Cytokine deposition alters leukocyte morphology and initial recruitment of monocytes and ?dT cells after corneal injury. Invest Ophthalmol Vis Sci. 2014 Apr 28; 55(4):2757-65. PMID: 24677104.
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    30. Basu S, Rajakaruna S, Dickinson BC, Chang CJ, Menko AS. Endogenous hydrogen peroxide production in the epithelium of the developing embryonic lens. Mol Vis. 2014; 20:458-67. PMID: 24744606.
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    31. Menko AS, Bleaken BM, Libowitz AA, Zhang L, Stepp MA, Walker JL. A central role for vimentin in regulating repair function during healing of the lens epithelium. Mol Biol Cell. 2014 Mar; 25(6):776-90. PMID: 24478454.
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    32. Menko AS, Bleaken BM, Walker JL. Regional-specific alterations in cell-cell junctions, cytoskeletal networks and myosin-mediated mechanical cues coordinate collectivity of movement of epithelial cells in response to injury. Exp Cell Res. 2014 Mar 10; 322(1):133-48. PMID: 24397950.
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    33. Basu S, Rajakaruna S, De Arcangelis A, Zhang L, Georges-Labouesse E, Menko AS. a6 integrin transactivates insulin-like growth factor receptor-1 (IGF-1R) to regulate caspase-3-mediated lens epithelial cell differentiation initiation. J Biol Chem. 2014 Feb 14; 289(7):3842-55. PMID: 24381169.
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    34. Enger TB, Samad-Zadeh A, Bouchie MP, Skarstein K, Galtung HK, Mera T, Walker J, Menko AS, Varelas X, Faustman DL, Jensen JL, Kukuruzinska MA. The Hippo signaling pathway is required for salivary gland development and its dysregulation is associated with Sjogren's syndrome. Lab Invest. 2013 Nov; 93(11):1203-18. PMID: 24080911.
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    35. Costello MJ, Brennan LA, Basu S, Chauss D, Mohamed A, Gilliland KO, Johnsen S, Menko S, Kantorow M. Autophagy and mitophagy participate in ocular lens organelle degradation. Exp Eye Res. 2013 Nov; 116:141-50. PMID: 24012988.
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    36. Leonard M, Zhang L, Bleaken BM, Menko AS. Distinct roles for N-Cadherin linked c-Src and fyn kinases in lens development. Dev Dyn. 2013 May; 242(5):469-84. PMID: 23361870.
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    37. Basu S, Rajakaruna S, Menko AS. Insulin-like growth factor receptor-1 and nuclear factor ?B are crucial survival signals that regulate caspase-3-mediated lens epithelial cell differentiation initiation. J Biol Chem. 2012 Mar 09; 287(11):8384-97. PMID: 22275359.
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    38. Leonard M, Zhang L, Zhai N, Cader A, Chan Y, Nowak RB, Fowler VM, Menko AS. Modulation of N-cadherin junctions and their role as epicenters of differentiation-specific actin regulation in the developing lens. Dev Biol. 2011 Jan 15; 349(2):363-77. PMID: 20969840.
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    39. Menko AS, Andley UP. aA-Crystallin associates with a6 integrin receptor complexes and regulates cellular signaling. Exp Eye Res. 2010 Nov; 91(5):640-51. PMID: 20709056.
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    40. Walker JL, Zhai N, Zhang L, Bleaken BM, Wolff I, Gerhart J, George-Weinstein M, Menko AS. Unique precursors for the mesenchymal cells involved in injury response and fibrosis. Proc Natl Acad Sci U S A. 2010 Aug 03; 107(31):13730-5. PMID: 20634425.
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    41. Gerhart J, Pfautz J, Neely C, Elder J, DuPrey K, Menko AS, Knudsen K, George-Weinstein M. Noggin producing, MyoD-positive cells are crucial for eye development. Dev Biol. 2009 Dec 01; 336(1):30-41. PMID: 19778533.
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    42. Nita-Lazar M, Noonan V, Rebustini I, Walker J, Menko AS, Kukuruzinska MA. Overexpression of DPAGT1 leads to aberrant N-glycosylation of E-cadherin and cellular discohesion in oral cancer. Cancer Res. 2009 Jul 15; 69(14):5673-80. PMID: 19549906.
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    43. Walker JL, Menko AS, Khalil S, Rebustini I, Hoffman MP, Kreidberg JA, Kukuruzinska MA. Diverse roles of E-cadherin in the morphogenesis of the submandibular gland: insights into the formation of acinar and ductal structures. Dev Dyn. 2008 Nov; 237(11):3128-41. PMID: 18816447.
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    44. Walker J, Menko AS. Integrins in lens development and disease. Exp Eye Res. 2009 Feb; 88(2):216-25. PMID: 18671967.
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    45. Leonard M, Chan Y, Menko AS. Identification of a novel intermediate filament-linked N-cadherin/gamma-catenin complex involved in the establishment of the cytoarchitecture of differentiated lens fiber cells. Dev Biol. 2008 Jul 15; 319(2):298-308. PMID: 18514185.
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    46. Xi JH, Bai F, Gross J, Townsend RR, Menko AS, Andley UP. Mechanism of small heat shock protein function in vivo: a knock-in mouse model demonstrates that the R49C mutation in alpha A-crystallin enhances protein insolubility and cell death. J Biol Chem. 2008 Feb 29; 283(9):5801-14. PMID: 18056999.
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    47. Zhou J, Leonard M, Van Bockstaele E, Menko AS. Mechanism of Src kinase induction of cortical cataract following exposure to stress: destabilization of cell-cell junctions. Mol Vis. 2007 Jul 24; 13:1298-310. PMID: 17679932.
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    48. Walker JL, Wolff IM, Zhang L, Menko AS. Activation of SRC kinases signals induction of posterior capsule opacification. Invest Ophthalmol Vis Sci. 2007 May; 48(5):2214-23. PMID: 17460282.
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    49. Page ME, Oropeza VC, Sparks SE, Qian Y, Menko AS, Van Bockstaele EJ. Repeated cannabinoid administration increases indices of noradrenergic activity in rats. Pharmacol Biochem Behav. 2007 Jan; 86(1):162-8. PMID: 17275893.
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    50. Weber GF, Menko AS. Phosphatidylinositol 3-kinase is necessary for lens fiber cell differentiation and survival. Invest Ophthalmol Vis Sci. 2006 Oct; 47(10):4490-9. PMID: 17003444.
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    51. Weber GF, Menko AS. Actin filament organization regulates the induction of lens cell differentiation and survival. Dev Biol. 2006 Jul 15; 295(2):714-29. PMID: 16678812.
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    52. Weber GF, Menko AS. The canonical intrinsic mitochondrial death pathway has a non-apoptotic role in signaling lens cell differentiation. J Biol Chem. 2005 Jun 10; 280(23):22135-45. PMID: 15826955.
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    53. Weber GF, Menko AS. Color image acquisition using a monochrome camera and standard fluorescence filter cubes. Biotechniques. 2005 Jan; 38(1):52, 54, 56. PMID: 15679085.
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    54. Zhou J, Menko AS. Coordinate signaling by Src and p38 kinases in the induction of cortical cataracts. Invest Ophthalmol Vis Sci. 2004 Jul; 45(7):2314-23. PMID: 15223811.
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    55. Walker JL, Zhang L, Menko AS. A signaling role for the uncleaved form of alpha 6 integrin in differentiating lens fiber cells. Dev Biol. 2002 Nov 15; 251(2):195-205. PMID: 12435352.
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    56. Walker JL, Zhang L, Menko AS. Transition between proliferation and differentiation for lens epithelial cells is regulated by Src family kinases. Dev Dyn. 2002 Aug; 224(4):361-72. PMID: 12203728.
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    57. Zhou J, Menko AS. The role of Src family kinases in cortical cataract formation. Invest Ophthalmol Vis Sci. 2002 Jul; 43(7):2293-300. PMID: 12091430.
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    58. Menko AS, Zhang L, Schiano F, Kreidberg JA, Kukuruzinska MA. Regulation of cadherin junctions during mouse submandibular gland development. Dev Dyn. 2002 Jul; 224(3):321-33. PMID: 12112462.
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    59. Walker JL, Zhang L, Zhou J, Woolkalis MJ, Menko AS. Role for alpha 6 integrin during lens development: Evidence for signaling through IGF-1R and ERK. Dev Dyn. 2002 Mar; 223(2):273-84. PMID: 11836791.
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    60. Menko AS, Kreidberg JA, Ryan TT, Van Bockstaele E, Kukuruzinska MA. Loss of alpha3beta1 integrin function results in an altered differentiation program in the mouse submandibular gland. Dev Dyn. 2001 Apr; 220(4):337-49. PMID: 11307167.
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    61. Van Bockstaele EJ, Menko AS, Drolet G. Neuroadaptive responses in brainstem noradrenergic nuclei following chronic morphine exposure. Mol Neurobiol. 2001 Apr-Jun; 23(2-3):155-71. PMID: 11817217.
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    62. Van Bockstaele EJ, Peoples J, Menko AS, McHugh K, Drolet G. Decreases in endogenous opioid peptides in the rat medullo-coerulear pathway after chronic morphine treatment. J Neurosci. 2000 Dec 01; 20(23):8659-66. PMID: 11102471.
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    63. Leong L, Menko AS, Grunwald GB. Differential expression of N- and B-cadherin during lens development. Invest Ophthalmol Vis Sci. 2000 Oct; 41(11):3503-10. PMID: 11006245.
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    64. Ferreira-Cornwell MC, Veneziale RW, Grunwald GB, Menko AS. N-cadherin function is required for differentiation-dependent cytoskeletal reorganization in lens cells in vitro. Exp Cell Res. 2000 Apr 10; 256(1):237-47. PMID: 10739670.
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    65. Walker JL, Menko AS. alpha6 Integrin is regulated with lens cell differentiation by linkage to the cytoskeleton and isoform switching. Dev Biol. 1999 Jun 15; 210(2):497-511. PMID: 10357906.
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    66. Fernandes RP, Cotanche DA, Lennon-Hopkins K, Erkan F, Menko AS, Kukuruzinska MA. Differential expression of proliferative, cytoskeletal, and adhesive proteins during postnatal development of the hamster submandibular gland. Histochem Cell Biol. 1999 Feb; 111(2):153-62. PMID: 10090576.
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    67. Claudio JO, Veneziale RW, Menko AS, Rouleau GA. Expression of schwannomin in lens and Schwann cells. Neuroreport. 1997 May 27; 8(8):2025-30. PMID: 9223096.
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    68. Menko AS, Philip NJ. Beta 1 integrins in epithelial tissues: a unique distribution in the lens. Exp Cell Res. 1995 Jun; 218(2):516-21. PMID: 7540985.
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    69. Boettiger D, Enomoto-Iwamoto M, Yoon HY, Hofer U, Menko AS, Chiquet-Ehrismann R. Regulation of integrin alpha 5 beta 1 affinity during myogenic differentiation. Dev Biol. 1995 May; 169(1):261-72. PMID: 7538477.
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    70. Enomoto-Iwamoto M, Menko AS, Philp N, Boettiger D. Evaluation of integrin molecules involved in substrate adhesion. Cell Adhes Commun. 1993 Dec; 1(3):191-202. PMID: 7521753.
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    71. Enomoto M, Leboy PS, Menko AS, Boettiger D. Beta 1 integrins mediate chondrocyte interaction with type I collagen, type II collagen, and fibronectin. Exp Cell Res. 1993 Apr; 205(2):276-85. PMID: 8387015.
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    72. Enomoto MI, Boettiger D, Menko AS. Alpha 5 integrin is a critical component of adhesion plaques in myogenesis. Dev Biol. 1993 Jan; 155(1):180-97. PMID: 8416832.
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    73. Leboy PS, Sullivan TA, Menko AS, Enomoto M. Ascorbic acid induction of chondrocyte maturation. Bone Miner. 1992 May; 17(2):242-6. PMID: 1611314.
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    74. Menko AS, Boettiger D. Inhibition of chicken embryo lens differentiation and lens junction formation in culture by pp60v-src. Mol Cell Biol. 1988 Apr; 8(4):1414-20. PMID: 2837640.
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    75. Boettiger D, Menko AS. Effect of oncogenes on chondrogenesis. Pathol Immunopathol Res. 1988; 7(1-2):32-7. PMID: 3265515.
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    76. Menko AS, Boettiger D. Occupation of the extracellular matrix receptor, integrin, is a control point for myogenic differentiation. Cell. 1987 Oct 09; 51(1):51-7. PMID: 3115595.
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    77. Menko AS, Klukas KA, Liu TF, Quade B, Sas DF, Preus DM, Johnson RG. Junctions between lens cells in differentiating cultures: structure, formation, intercellular permeability, and junctional protein expression. Dev Biol. 1987 Oct; 123(2):307-20. PMID: 3653509.
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    78. Sas DF, Sas MJ, Johnson KR, Menko AS, Johnson RG. Junctions between lens fiber cells are labeled with a monoclonal antibody shown to be specific for MP26. J Cell Biol. 1985 Jan; 100(1):216-25. PMID: 3880752.
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    79. Menko AS, Klukas KA, Johnson RG. Chicken embryo lens cultures mimic differentiation in the lens. Dev Biol. 1984 May; 103(1):129-41. PMID: 6370757.
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    80. Menko AS, Toyama Y, Boettiger D, Holtzer H. Altered cell spreading in cytochalasin B: a possible role for intermediate filaments. Mol Cell Biol. 1983 Jan; 3(1):113-25. PMID: 6298602.
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    81. Menko AS, Croop J, Toyama Y, Holtzer H, Boettiger D. The response of chicken embryo dermal fibroblasts to cytochalasin B is altered by Rous sarcoma virus-induced cell transformation. Mol Cell Biol. 1982 Mar; 2(3):320-30. PMID: 6287234.
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    82. Atkinson MM, Menko AS, Johnson RG, Sheppard JR, Sheridan JD. Rapid and reversible reduction of junctional permeability in cells infected with a temperature-sensitive mutant of avian sarcoma virus. J Cell Biol. 1981 Nov; 91(2 Pt 1):573-8. PMID: 6273447.
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    83. Menko AS, Tan KB. Nuclear tubulin of tissue culture cells. Biochim Biophys Acta. 1980 May 07; 629(2):359-70. PMID: 7388040.
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    84. Menko AS, Sokol F, Clark HF, Tan KB. Structural and enzymatic characterization of viper C-type virus. Arch Virol. 1976; 50(1-2):125-35. PMID: 56928.
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