Ashakumary Lakshmikuttyamma

TitleAsst Prof CHP
InstitutionThomas Jefferson University
DepartmentJSP - Pharmaceutical Science
Address1020 Locust St.
Philadelphia PA 19107
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Badgeley A, Anwar H, Modi K, Murphy P, Lakshmikuttyamma A. Effect of probiotics and gut microbiota on anti-cancer drugs: Mechanistic perspectives. Biochim Biophys Acta Rev Cancer. 2020 Dec 17; 1875(1):188494. PMID: 33346129.
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    2. Modi K, Lawson S, Chen G, Tumuluri D, Rekhtman I, Kurtz M, Brailoiu GC, Chen QH, Lakshmikuttyamma A. 1-Chromonyl-5-Imidazolylpentadienone Demonstrates Anti-Cancer Action against TNBC and Exhibits Synergism with Paclitaxel. Int J Mol Sci. 2020 Aug 12; 21(16). PMID: 32806551.
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    3. Selvakumar P, Badgeley A, Murphy P, Anwar H, Sharma U, Lawrence K, Lakshmikuttyamma A. Flavonoids and Other Polyphenols Act as Epigenetic Modifiers in Breast Cancer. Nutrients. 2020 Mar 13; 12(3). PMID: 32183060.
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    4. Kundur S, Prayag A, Selvakumar P, Nguyen H, McKee L, Cruz C, Srinivasan A, Shoyele S, Lakshmikuttyamma A. Synergistic anticancer action of quercetin and curcumin against triple-negative breast cancer cell lines. J Cell Physiol. 2018 Nov 27. PMID: 30478904.
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    5. Perepelyuk M, Maher C, Lakshmikuttyamma A, Shoyele SA. Aptamer-hybrid nanoparticle bioconjugate efficiently delivers miRNA-29b to non-small-cell lung cancer cells and inhibits growth by downregulating essential oncoproteins. Int J Nanomedicine. 2016; 11:3533-44. PMID: 27555773.
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    6. Dim N, Perepelyuk M, Gomes O, Thangavel C, Liu Y, Den R, Lakshmikuttyamma A, Shoyele SA. Novel targeted siRNA-loaded hybrid nanoparticles: preparation, characterization and in vitro evaluation. J Nanobiotechnology. 2015; 13(1):61. PMID: 26410728.
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    7. Srinivasan A, Thangavel C, Liu Y, Shoyele S, Den RB, Selvakumar P, Lakshmikuttyamma A. Quercetin regulates ß-catenin signaling and reduces the migration of triple negative breast cancer. Mol Carcinog. 2015 May 12. PMID: 25968914.
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    8. Lakshmikuttyamma A, Sun Y, Lu B, Undieh AS, Shoyele SA. Stable and Efficient Transfection of siRNA for Mutated KRAS Silencing Using Novel Hybrid Nanoparticles. Mol Pharm. 2014 Dec 1; 11(12):4415-24. PMID: 25340957.
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    9. Selvakumar P, Owens TA, David JM, Petrelli NJ, Christensen BC, Lakshmikuttyamma A, Rajasekaran AK. Epigenetic silencing of Na,K-ATPase ß 1 subunit gene ATP1B1 by methylation in clear cell renal cell carcinoma. Epigenetics. 2014 Jan 22; 9(4). PMID: 24452105.
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    10. Srinivasan AR, Lakshmikuttyamma A, Shoyele SA. Investigation of the Stability and Cellular Uptake of Self-Associated Monoclonal Antibody (MAb) Nanoparticles by Non-Small Lung Cancer Cells. Mol Pharm. 2013 Sep 3; 10(9):3275-84. PMID: 23915336.
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    11. Lakshmikuttyamma A, Scott SA, DeCoteau JF, Geyer CR. Reexpression of epigenetically silenced AML tumor suppressor genes by SUV39H1 inhibition. Oncogene. 2010 Jan 28; 29(4):576-88. PMID: 19881540.
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    12. Selvakumar P, Lakshmikuttyamma A, Sharma RK. Biochemical characterization of bovine brain myristoyl-CoA:protein N-myristoyltransferase type 2. J Biomed Biotechnol. 2009; 2009:907614. PMID: 19746168.
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    13. Selvakumar P, Lakshmikuttyamma A, Das U, Pati HN, Dimmock JR, Sharma RK. NC2213: a novel methionine aminopeptidase 2 inhibitor in human colon cancer HT29 cells. Mol Cancer. 2009; 8:65. PMID: 19703310.
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    14. Lakshmikuttyamma A, Takahashi N, Pastural E, Torlakovic E, Amin HM, Garcia-Manero G, Voralia M, Czader M, DeCoteau JF, Geyer CR. RIZ1 is potential CML tumor suppressor that is down-regulated during disease progression. J Hematol Oncol. 2009; 2:28. PMID: 19602237.
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    15. Singh N, Shrivastav A, Olson D, Lakshmikuttyamma A, Ross A, Parr T, Bardsley RG, Sharma RK. Cardiac high molecular weight calmodulin-binding protein is homologous to calpastatin I and calpastatin II. Biochem Biophys Res Commun. 2008 Aug 29; 373(3):387-91. PMID: 18572013.
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    16. Lakshmikuttyamma A, Pastural E, Takahashi N, Sawada K, Sheridan DP, DeCoteau JF, Geyer CR. Bcr-Abl induces autocrine IGF-1 signaling. Oncogene. 2008 Jun 19; 27(27):3831-44. PMID: 18246120.
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    17. Lakshmikuttyamma A, Selvakumar P, Tuchek J, Sharma RK. Myristoyltransferase and calcineurin: novel molecular therapeutic target for epilepsy. Prog Neurobiol. 2008 Jan; 84(1):77-84. PMID: 17997006.
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    18. Sharma RK, Das SB, Lakshmikuttyamma A, Selvakumar P, Shrivastav A. Regulation of calmodulin-stimulated cyclic nucleotide phosphodiesterase (PDE1): review. Int J Mol Med. 2006 Jul; 18(1):95-105. PMID: 16786160.
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    19. Selvakumar P, Lakshmikuttyamma A, Shrivastav A, Das SB, Dimmock JR, Sharma RK. Potential role of N-myristoyltransferase in cancer. Prog Lipid Res. 2007 Jan; 46(1):1-36. PMID: 16846646.
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    20. Lakshmikuttyamma A, Selvakumar P, Sharma RK. Interaction between heat shock protein 70 kDa and calcineurin in cardiovascular systems (Review). Int J Mol Med. 2006 Mar; 17(3):419-23. PMID: 16465387.
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    21. Lakshmikuttyamma A, Selvakumar P, Charavaryamath C, Singh B, Tuchek J, Sharma RK. Expression of calcineurin and its interacting proteins in epileptic fowl. J Neurochem. 2006 Jan; 96(2):366-73. PMID: 16336633.
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    22. Selvakumar P, Lakshmikuttyamma A, Dimmock JR, Sharma RK. Methionine aminopeptidase 2 and cancer. Biochim Biophys Acta. 2006 Apr; 1765(2):148-54. PMID: 16386852.
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    23. Selvakumar P, Lakshmikuttyamma A, Anderson DH, Sharma RK. Molecular cloning, expression, purification and characterization of calcineurin from bovine cardiac muscle. Biochimie. 2005 Nov; 87(11):975-83. PMID: 15967565.
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    24. Selvakumar P, Lakshmikuttyamma A, Charavaryamath C, Singh B, Tuchek J, Sharma RK. Expression of myristoyltransferase and its interacting proteins in epilepsy. Biochem Biophys Res Commun. 2005 Oct 7; 335(4):1132-9. PMID: 16129091.
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    25. Lakshmikuttyamma A, Selvakumar P, Kanthan R, Kanthan SC, Sharma RK. Increased expression of calcineurin in human colorectal adenocarcinomas. J Cell Biochem. 2005 Jul 1; 95(4):731-9. PMID: 15832371.
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    26. Lakshmikuttyamma A, Selvakumar P, Anderson DH, Datla RS, Sharma RK. Molecular cloning of bovine cardiac muscle heat-shock protein 70 kDa and its phosphorylation by cAMP-dependent protein kinase in vitro. Biochemistry. 2004 Oct 26; 43(42):13340-7. PMID: 15491140.
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    27. Lakshmikuttyamma A, Selvakumar P, Sharma AR, Anderson DH, Sharma RK. In vitro proteolytic degradation of bovine brain calcineurin by m-calpain. Neurochem Res. 2004 Oct; 29(10):1913-21. PMID: 15532547.
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    28. Lakshmikuttyamma A, Selvakumar P, Kanthan R, Kanthan SC, Sharma RK. Overexpression of m-calpain in human colorectal adenocarcinomas. Cancer Epidemiol Biomarkers Prev. 2004 Oct; 13(10):1604-9. PMID: 15466976.
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    29. Selvakumar P, Lakshmikuttyamma A, Lawman Z, Bonham K, Dimmock JR, Sharma RK. Expression of methionine aminopeptidase 2, N-myristoyltransferase, and N-myristoyltransferase inhibitor protein 71 in HT29. Biochem Biophys Res Commun. 2004 Sep 24; 322(3):1012-7. PMID: 15336565.
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    30. Selvakumar P, Lakshmikuttyamma A, Pasha MK, King MJ, Olson DJ, Mori S, Ross AR, Hayashi K, Dimmock JR, Sharma RK. N-myristoyltransferase inhibitor protein is homologous to heat shock cognate protein 70. J Cell Biochem. 2004 Jun 1; 92(3):573-8. PMID: 15156568.
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    31. Selvakumar P, Lakshmikuttyamma A, Kanthan R, Kanthan SC, Dimmock JR, Sharma RK. High expression of methionine aminopeptidase 2 in human colorectal adenocarcinomas. Clin Cancer Res. 2004 Apr 15; 10(8):2771-5. PMID: 15102683.
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    32. Lakshmikuttyamma A, Selvakumar P, Kakkar R, Kanthan R, Wang R, Sharma RK. Activation of calcineurin expression in ischemia-reperfused rat heart and in human ischemic myocardium. J Cell Biochem. 2003 Dec 1; 90(5):987-97. PMID: 14624458.
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