Abdolmohamad Rostami

TitleProfessor & Chair JMC
InstitutionThomas Jefferson University
DepartmentChair SKMC
Address1025 Walnut St.
Philadelphia PA 19107
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Xiao Y, Wang SK, Zhang Y, Rostami A, Kenkare A, Casella G, Yuan ZQ, Li X. Role of extracellular vesicles in neurodegenerative diseases. Prog Neurobiol. 2021 Jun; 201:102022. PMID: 33617919.
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    2. Xiao D, Zhang W, Wang Q, Li X, Zhang Y, Rasouli J, Casella G, Ciric B, Curtis M, Rostami A, Zhang GX. CRISPR-mediated rapid generation of neural cell-specific knockout mice facilitates research in neurophysiology and pathology. Mol Ther Methods Clin Dev. 2021 Mar 12; 20:755-764. PMID: 33738329.
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    3. Han B, Zhang YY, Ye ZQ, Xiao Y, Rasouli J, Wu WC, Ye SM, Guo XY, Zhu L, Rostami A, Wang LB, Zhang Y, Li X. Montelukast alleviates inflammation in experimental autoimmune encephalomyelitis by altering Th17 differentiation in a mouse model. Immunology. 2021 Jan 22. PMID: 33480040.
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    4. Casella G, Rasouli J, Boehm A, Zhang W, Xiao D, Ishikawa LLW, Thome R, Li X, Hwang D, Porazzi P, Molugu S, Tang HY, Zhang GX, Ciric B, Rostami A. Oligodendrocyte-derived extracellular vesicles as antigen-specific therapy for autoimmune neuroinflammation in mice. Sci Transl Med. 2020 Nov 04; 12(568). PMID: 33148622.
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    5. Casella G, Rasouli J, Thome R, Descamps HC, Vattikonda A, Ishikawa L, Boehm A, Hwang D, Zhang W, Xiao D, Park J, Zhang GX, Alvarez JI, Rostami A, Ciric B. Interferon-?/Interleukin-27 Axis Induces Programmed Death Ligand 1 Expression in Monocyte-Derived Dendritic Cells and Restores Immune Tolerance in Central Nervous System Autoimmunity. Front Immunol. 2020; 11:576752. PMID: 33193372.
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    6. Rasouli J, Casella G, Yoshimura S, Zhang W, Xiao D, Garifallou J, Gonzalez MV, Wiedeman A, Kus A, Mari ER, Fortina P, Hakonarson H, Long SA, Zhang GX, Ciric B, Rostami A. A distinct GM-CSF+ T helper cell subset requires T-bet to adopt a TH1 phenotype and promote neuroinflammation. Sci Immunol. 2020 10 23; 5(52). PMID: 33097590.
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    7. Li X, Zhang Y, Zhang WF, Xiao D, Ciric B, Rostami A, Zhang GX. P7C3 attenuates CNS autoimmunity by inhibiting Th17 cell differentiation. Cell Mol Immunol. 2020 Jul 09. PMID: 32647376.
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    8. Thome R, Casella G, Lotfi N, Ishikawa LWL, Wang Q, Ciric B, Zhang GX, Rostami A. Primaquine elicits Foxp3+ regulatory T cells with a superior ability to limit CNS autoimmune inflammation. J Autoimmun. 2020 Jun 25; 102505. PMID: 32595012.
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    9. Thome R, Boehm A, Ishikawa LLW, Casella G, Munhoz J, Ciric B, Zhang GX, Rostami A. Comprehensive Analysis of the Immune and Stromal Compartments of the CNS in EAE Mice Reveal Pathways by Which Chloroquine Suppresses Neuroinflammation. Brain Sci. 2020 Jun 05; 10(6). PMID: 32516999.
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    10. Apostolopoulos V, Rostami A, Matsoukas J. The Long Road of Immunotherapeutics against Multiple Sclerosis. Brain Sci. 2020 May 11; 10(5). PMID: 32403377.
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    11. Safavi F, Thome R, Li Z, Zhang GX, Rostami A. Dimethyl fumarate suppresses granulocyte macrophage colony-stimulating factor-producing Th1 cells in CNS neuroinflammation. Neurol Neuroimmunol Neuroinflamm. 2020 Jul; 7(4). PMID: 32371548.
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    12. Thome R, Boehm A, Ishikawa LLW, Casella G, Munhoz J, Ciric B, Zhang GX, Rostami A. Chloroquine reduces Th17 cell differentiation by stimulating T-bet expression in T cells. Cell Mol Immunol. 2020 Apr 20. PMID: 32313209.
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    13. Zhang Y, Li X, Ciric B, Curtis MT, Chen WJ, Rostami A, Zhang GX. A dual effect of ursolic acid to the treatment of multiple sclerosis through both immunomodulation and direct remyelination. Proc Natl Acad Sci U S A. 2020 Apr 06. PMID: 32253301.
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    14. Casella G, Rasouli J, Mason K, Boehm A, Kumar G, Hwang D, Thome R, Ishikawa L, Zhang GX, Ciric B, Rostami A. A serine protease inhibitor suppresses autoimmune neuroinflammation by activating the STING/IFN-ß axis in macrophages. Cell Mol Immunol. 2020 Mar 20. PMID: 32203194.
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    15. Chen J, Martindale JL, Abdelmohsen K, Kumar G, Fortina PM, Gorospe M, Rostami A, Yu S. RNA-Binding Protein HuR Promotes Th17 Cell Differentiation and Can Be Targeted to Reduce Autoimmune Neuroinflammation. J Immunol. 2020 Apr 15; 204(8):2076-2087. PMID: 32169842.
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    16. Kalantari T, Ciric B, Kamali-Sarvestani E, Rostami A. Bone marrow dendritic cells deficient for CD40 and IL-23p19 are tolerogenic in vitro. Iran J Basic Med Sci. 2020 Mar; 23(3):287-292. PMID: 32440313.
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    17. Lotfi N, Zhang GX, Esmaeil N, Rostami A. Evaluation of the effect of GM-CSF blocking on the phenotype and function of human monocytes. Sci Rep. 2020 Jan 31; 10(1):1567. PMID: 32005854.
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    18. Safavi F, Thome R, Li Z, Wang L, Rasouli J, Ciric B, Zhang GX, Rostami A. A serine protease inhibitor induces type 1 regulatory T cells through IFN-?/STAT1 signaling. Cell Mol Immunol. 2020 Jan 03. PMID: 31900456.
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    19. Tian J, Casella G, Zhang Y, Rostami A, Li X. Potential roles of extracellular vesicles in the pathophysiology, diagnosis, and treatment of autoimmune diseases. Int J Biol Sci. 2020; 16(4):620-632. PMID: 32025210.
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    20. Yoshimura S, Thome R, Konno S, Mari ER, Rasouli J, Hwang D, Boehm A, Li Y, Zhang GX, Ciric B, Rostami A. IL-9 Controls Central Nervous System Autoimmunity by Suppressing GM-CSF Production. J Immunol. 2019 Dec 18. PMID: 31852750.
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    21. Zhang Y, Lu XY, Casella G, Tian J, Ye ZQ, Yang T, Han JJ, Jia LY, Rostami A, Li X. Generation of Oligodendrocyte Progenitor Cells From Mouse Bone Marrow Cells. Front Cell Neurosci. 2019; 13:247. PMID: 31231194.
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    22. Lotfi N, Thome R, Rezaei N, Zhang GX, Rezaei A, Rostami A, Esmaeil N. Roles of GM-CSF in the Pathogenesis of Autoimmune Diseases: An Update. Front Immunol. 2019; 10:1265. PMID: 31275302.
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    23. Wang Q, Thome R, Rostami A, Ma CG, Zhang GX. The selective retinoic acid receptor-a agonist AM580 fails to control autoimmune neuroinflammation. Cell Mol Immunol. 2019 Aug; 16(8):727-729. PMID: 31160758.
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    24. Zhang Y, Lu XY, Ye ZQ, Ciric B, Ma CG, Rostami A, Li X, Zhang GX. Combination Therapy With Fingolimod and Neural Stem Cells Promotes Functional Myelination in vivo Through a Non-immunomodulatory Mechanism. Front Cell Neurosci. 2019; 13:14. PMID: 30804753.
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    25. Zhou F, Zhang GX, Rostami A. Distinct Role of IL-27 in Immature and LPS-Induced Mature Dendritic Cell-Mediated Development of CD4+ CD127+3G11+ Regulatory T Cell Subset. Front Immunol. 2018; 9:2562. PMID: 30483251.
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    26. Thome R, Bonfanti AP, Rasouli J, Mari ER, Zhang GX, Rostami A, Verinaud L. Chloroquine-treated dendritic cells require STAT1 signaling for their tolerogenic activity. Eur J Immunol. 2018 Mar 23. PMID: 29572810.
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    27. Imitola J, Rasouli J, Watanabe F, Mahajan K, Sharan AD, Ciric B, Zhang GX, Rostami A. Elevated expression of granulocyte-macrophage colony-stimulating factor receptor in multiple sclerosis lesions. J Neuroimmunol. 2018 Apr 15; 317:45-54. PMID: 29290406.
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    28. Chen J, Adamiak W, Huang G, Atasoy U, Rostami A, Yu S. Interaction of RNA-binding protein HuR and miR-466i regulates GM-CSF expression. Sci Rep. 2017 Dec 08; 7(1):17233. PMID: 29222492.
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    29. Thomé R, Moore JN, Mari ER, Rasouli J, Hwang D, Yoshimura S, Ciric B, Zhang GX, Rostami AM. Induction of Peripheral Tolerance in Ongoing Autoimmune Inflammation Requires Interleukin 27 Signaling in Dendritic Cells. Front Immunol. 2017; 8:1392. PMID: 29163476.
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    30. Bhopale MK, Hilliard B, Constantinescu CS, Phillips SM, Rostami A. DAB389IL-2 recombinant fusion toxin effect on lymphocyte- and macrophage-producing cytokine subpopulation cells in experimentally induced demyelinating disease in mice. Immunopharmacol Immunotoxicol. 2017 Dec; 39(6):318-329. PMID: 28929835.
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    31. Zhou F, Zhang GX, Rostami A. LPS-treated bone marrow-derived dendritic cells induce immune tolerance through modulating differentiation of CD4+ regulatory T cell subpopulations mediated by 3G11 and CD127. Immunol Res. 2017 Jun; 65(3):630-638. PMID: 27942984.
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    32. Shirazi HA, Rasouli J, Ciric B, Wei D, Rostami A, Zhang GX. 1,25-Dihydroxyvitamin D3 suppressed experimental autoimmune encephalomyelitis through both immunomodulation and oligodendrocyte maturation. Exp Mol Pathol. 2017 Jun; 102(3):515-521. PMID: 28552332.
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    33. Crooks J, Gargaro M, Vacca C, Volpi C, Pirro M, Scalisi G, Turco A, Romani R, Matino D, Rostami A, Puccetti P, Gran B, Fallarino F. CpG Type A Induction of an Early Protective Environment in Experimental Multiple Sclerosis. Mediators Inflamm. 2017; 2017:1380615. PMID: 28356656.
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    34. Zhang Y, Li X, Ciric B, Ma CG, Gran B, Rostami A, Zhang GX. Effect of Fingolimod on Neural Stem Cells: A Novel Mechanism and Broadened Application for Neural Repair. Mol Ther. 2017 Feb 01; 25(2):401-415. PMID: 28153091.
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    35. Wang L, Li Z, Ciric B, Safavi F, Zhang GX, Rostami A. Selective depletion of CD11c(+) CD11b(+) dendritic cells partially abrogates tolerogenic effects of intravenous MOG in murine EAE. Eur J Immunol. 2016 Oct; 46(10):2454-2466. PMID: 27338697.
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    36. Nasr Z, Majed M, Rostami A, Sahraian MA, Minagar A, Amini A, McGee JC, Etemadifar M. Prevalence of multiple sclerosis in Iranian emigrants: review of the evidence. Neurol Sci. 2016 Nov; 37(11):1759-1763. PMID: 27351545.
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    37. Li X, Zhang Y, Yan Y, Ciric B, Ma CG, Chin J, Curtis M, Rostami A, Zhang GX. LINGO-1-Fc-Transduced Neural Stem Cells Are Effective Therapy for Chronic Stage Experimental Autoimmune Encephalomyelitis. Mol Neurobiol. 2016 Jun 25. PMID: 27344330.
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    38. Mari ER, Rasouli J, Ciric B, Moore JN, Conejo-Garcia JR, Rajasagi N, Zhang GX, Rabinovich GA, Rostami A. Galectin-1 is essential for the induction of MOG35-55 -based intravenous tolerance in experimental autoimmune encephalomyelitis. Eur J Immunol. 2016 Jul; 46(7):1783-96. PMID: 27151444.
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    39. Li X, Zhang Y, Yan Y, Ciric B, Ma CG, Gran B, Curtis M, Rostami A, Zhang GX. Neural Stem Cells Engineered to Express Three Therapeutic Factors Mediate Recovery from Chronic Stage CNS Autoimmunity. Mol Ther. 2016 Aug; 24(8):1456-69. PMID: 27203442.
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    40. Zhou F, Zhang GX, Rostami A. Apoptotic cell-treated dendritic cells induce immune tolerance by specifically inhibiting development of CD4(+) effector memory T cells. Immunol Res. 2016 Feb; 64(1):73-81. PMID: 26111522.
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    41. Xie C, Ciric B, Yu S, Zhang GX, Rostami A. IL-12Rß2 has a protective role in relapsing-remitting experimental autoimmune encephalomyelitis. J Neuroimmunol. 2016 Feb 15; 291:59-69. PMID: 26857496.
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    42. Zhang Y, Li X, Ciric B, Ma CG, Gran B, Rostami A, Zhang GX. Therapeutic effect of baicalin on experimental autoimmune encephalomyelitis is mediated by SOCS3 regulatory pathway. Sci Rep. 2015; 5:17407. PMID: 26616302.
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    43. Farjam M, Zhang GX, Ciric B, Rostami A. Emerging immunopharmacological targets in multiple sclerosis. J Neurol Sci. 2015 Nov 15; 358(1-2):22-30. PMID: 26440421.
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    44. Ding X, Cao F, Cui L, Ciric B, Zhang GX, Rostami A. IL-9 signaling affects central nervous system resident cells during inflammatory stimuli. Exp Mol Pathol. 2015 Dec; 99(3):570-4. PMID: 26216406.
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    45. Rasouli J, Ciric B, Imitola J, Gonnella P, Hwang D, Mahajan K, Mari ER, Safavi F, Leist TP, Zhang GX, Rostami A. Expression of GM-CSF in T Cells Is Increased in Multiple Sclerosis and Suppressed by IFN-ß Therapy. J Immunol. 2015 Jun 1; 194(11):5085-93. PMID: 25917097.
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    46. Mari ER, Moore JN, Zhang GX, Rostami A. Mechanisms of immunological tolerance in central nervous system inflammatory demyelination. Clin Exp Neuroimmunol. 2015 Aug 1; 6(3):264-274. PMID: 26425145.
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    47. Ding X, Yan Y, Li X, Li K, Ciric B, Yang J, Zhang Y, Wu S, Xu H, Chen W, Lovett-Racke AE, Zhang GX, Rostami A. Silencing IFN-? Binding/Signaling in Astrocytes versus Microglia Leads to Opposite Effects on Central Nervous System Autoimmunity. J Immunol. 2015 May 1; 194(9):4251-64. PMID: 25795755.
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    48. Safavi F, Li H, Gonnella P, Mari ER, Rasouli J, Zhang GX, Rostami A. c-kit plays a critical role in induction of intravenous tolerance in experimental autoimmune encephalomyelitis. Immunol Res. 2015 Mar; 61(3):294-302. PMID: 25588867.
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    49. Londin E, Loher P, Telonis AG, Quann K, Clark P, Jing Y, Hatzimichael E, Kirino Y, Honda S, Lally M, Ramratnam B, Comstock CE, Knudsen KE, Gomella L, Spaeth GL, Hark L, Katz LJ, Witkiewicz A, Rostami A, Jimenez SA, Hollingsworth MA, Yeh JJ, Shaw CA, McKenzie SE, Bray P, Nelson PT, Zupo S, Van Roosbroeck K, Keating MJ, Calin GA, Yeo C, Jimbo M, Cozzitorto J, Brody JR, Delgrosso K, Mattick JS, Fortina P, Rigoutsos I. Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs. Proc Natl Acad Sci U S A. 2015 Mar 10; 112(10):E1106-15. PMID: 25713380.
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    50. Shirazi HA, Rasouli J, Ciric B, Rostami A, Zhang GX. 1,25-Dihydroxyvitamin D3 enhances neural stem cell proliferation and oligodendrocyte differentiation. Exp Mol Pathol. 2015 Apr; 98(2):240-5. PMID: 25681066.
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    51. Rostami A, Ciric B. Astrocyte-derived lactosylceramide implicated in multiple sclerosis. Nat Med. 2014 Oct 8; 20(10):1092-3. PMID: 25295934.
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    52. El-Behi M, Dai H, Magalhaes JG, Hwang D, Zhang GX, Rostami A, Ciric B. Committed Tc17 cells are phenotypically and functionally resistant to the effects of IL-27. Eur J Immunol. 2014 Oct; 44(10):3003-14. PMID: 25070084.
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    53. Fitzgerald DC, O'Brien K, Young A, Fonseca-Kelly Z, Rostami A, Gran B. Interferon regulatory factor (IRF) 3 is critical for the development of experimental autoimmune encephalomyelitis. J Neuroinflammation. 2014; 11(1):130. PMID: 25069698.
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    54. Yang J, Yan Y, Xia Y, Kang T, Li X, Ciric B, Xu H, Rostami A, Zhang GX. Neurotrophin 3 transduction augments remyelinating and immunomodulatory capacity of neural stem cells. Mol Ther. 2013 Nov 19; 22(2):440-50. PMID: 24247929.
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    55. Yan Y, Li Z, Zhang GX, Williams MS, Carey GB, Zhang J, Rostami A, Xu H. Anti-MS4a4B treatment abrogates MS4a4B-mediated protection in T cells and ameliorates experimental autoimmune encephalomyelitis. Apoptosis. 2013 Sep; 18(9):1106-19. PMID: 23801080.
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    56. Bhopale MK, Hilliard B, Constantinescu CS, Fujioka T, Ventura E, Phillips SM, Rostami A. DAB389IL-2 suppresses autoimmune inflammation in the CNS and inhibits T cell-mediated lysis of glial target cells. Exp Mol Pathol. 2014 Feb; 96(1):108-17. PMID: 23872438.
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    57. Wu S, Li K, Yan Y, Gran B, Han Y, Zhou F, Guan YT, Rostami A, Zhang GX. Intranasal Delivery of Neural Stem Cells: A CNS-specific, Non-invasive Cell-based Therapy for Experimental Autoimmune Encephalomyelitis. J Clin Cell Immunol. 2013 Jun 1; 4(3). PMID: 24244890.
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    58. Zhou F, Ciric B, Zhang GX, Rostami A. Immune tolerance induced by intravenous transfer of immature dendritic cells via up-regulating numbers of suppressive IL-10(+) IFN-? (+)-producing CD4 (+) T cells. Immunol Res. 2013 May; 56(1):1-8. PMID: 23292714.
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    59. Li Z, Li K, Zhu L, Kan Q, Yan Y, Kumar P, Xu H, Rostami A, Zhang GX. Inhibitory effect of IL-17 on neural stem cell proliferation and neural cell differentiation. BMC Immunol. 2013; 14:20. PMID: 23617463.
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    60. Rostami A, Ciric B. Role of Th17 cells in the pathogenesis of CNS inflammatory demyelination. J Neurol Sci. 2013 Oct 15; 333(1-2):76-87. PMID: 23578791.
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    61. Fitzgerald DC, Fonseca-Kelly Z, Cullimore ML, Safabakhsh P, Saris CJ, Zhang GX, Rostami A. Independent and Interdependent Immunoregulatory Effects of IL-27, IFN-ß, and IL-10 in the Suppression of Human Th17 Cells and Murine Experimental Autoimmune Encephalomyelitis. J Immunol. 2013 Apr 1; 190(7):3225-34. PMID: 23455508.
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    62. Zhou F, Lauretti E, di Meco A, Ciric B, Gonnella P, Zhang GX, Rostami A. Intravenous transfer of apoptotic cell-treated dendritic cells leads to immune tolerance by blocking Th17 cell activity. Immunobiology. 2013 Aug; 218(8):1069-76. PMID: 23587571.
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    63. Kalantari T, Kamali-Sarvestani E, Zhang GX, Safavi F, Lauretti E, Khedmati ME, Rostami A. Generation of large numbers of highly purified dendritic cells from bone marrow progenitor cells after co-culture with syngeneic murine splenocytes. Exp Mol Pathol. 2013 Apr; 94(2):336-42. PMID: 23269574.
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    64. Safavi F, Rostami A. Role of serine proteases in inflammation: Bowman-Birk protease inhibitor (BBI) as a potential therapy for autoimmune diseases. Exp Mol Pathol. 2012 Dec; 93(3):428-33. PMID: 23022357.
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    65. Li H, Gonnella P, Safavi F, Vessal G, Nourbakhsh B, Zhou F, Zhang GX, Rostami A. Low dose zymosan ameliorates both chronic and relapsing experimental autoimmune encephalomyelitis. J Neuroimmunol. 2013 Jan 15; 254(1-2):28-38. PMID: 23010280.
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    66. Zhou F, Ciric B, Li H, Yan Y, Li K, Cullimore M, Lauretti E, Gonnella P, Zhang GX, Rostami A. IL-10 deficiency blocks the ability of LPS to regulate expression of tolerance-related molecules on dendritic cells. Eur J Immunol. 2012 Jun; 42(6):1449-58. PMID: 22622800.
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    67. Yan Y, Zhang GX, Williams MS, Carey GB, Li H, Yang J, Rostami A, Xu H. TCR stimulation upregulates MS4a4B expression through induction of AP-1 transcription factor during T cell activation. Mol Immunol. 2012 Sep; 52(2):71-8. PMID: 22595231.
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    68. Yang J, Yan Y, Ma CG, Kang T, Zhang N, Gran B, Xu H, Li K, Ciric B, Zangaladze A, Curtis M, Rostami A, Zhang GX. Accelerated and enhanced effect of CCR5-transduced bone marrow neural stem cells on autoimmune encephalomyelitis. Acta Neuropathol. 2012 Oct; 124(4):491-503. PMID: 22526024.
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    69. Fitzgerald DC, Zhang GX, Yu S, Cullimore ML, Zhao Z, Rostami A. Intravenous tolerance effectively overcomes enhanced pro-inflammatory responses and experimental autoimmune encephalomyelitis severity in the absence of IL-12 receptor signaling. J Neuroimmunol. 2012 Jun 15; 247(1-2):32-7. PMID: 22522341.
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    70. Yan Y, Ding X, Li K, Ciric B, Wu S, Xu H, Gran B, Rostami A, Zhang GX. CNS-specific therapy for ongoing EAE by silencing IL-17 pathway in astrocytes. Mol Ther. 2012 Jul; 20(7):1338-48. PMID: 22434134.
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    71. Dai H, Ciric B, Zhang GX, Rostami A. Interleukin-10 plays a crucial role in suppression of experimental autoimmune encephalomyelitis by Bowman-Birk inhibitor. J Neuroimmunol. 2012 Apr; 245(1-2):1-7. PMID: 22365083.
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    72. Dai H, Ciric B, Zhang GX, Rostami A. Bowman-Birk Inhibitor attenuates experimental autoimmune encephalomyelitis by delaying infiltration of inflammatory cells into the CNS. Immunol Res. 2011 Dec; 51(2-3):145-52. PMID: 22095543.
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    73. Kalantari T, Kamali-Sarvestani E, Ciric B, Karimi MH, Kalantari M, Faridar A, Xu H, Rostami A. Generation of immunogenic and tolerogenic clinical-grade dendritic cells. Immunol Res. 2011 Dec; 51(2-3):153-60. PMID: 22105838.
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    74. Li H, Nourbakhsh B, Cullimore M, Zhang GX, Rostami A. IL-9 is important for T-cell activation and differentiation in autoimmune inflammation of the central nervous system. Eur J Immunol. 2011 Aug; 41(8):2197-206. PMID: 21674475.
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    75. Li H, Nourbakhsh B, Safavi F, Li K, Xu H, Cullimore M, Zhou F, Zhang G, Rostami A. Kit (W-sh) mice develop earlier and more severe experimental autoimmune encephalomyelitis due to absence of immune suppression. J Immunol. 2011 Jul 1; 187(1):274-82. PMID: 21646293.
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    76. El-Behi M, Ciric B, Dai H, Yan Y, Cullimore M, Safavi F, Zhang GX, Dittel BN, Rostami A. The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF. Nat Immunol. 2011 Jun; 12(6):568-75. PMID: 21516111.
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    77. Shindler KS, Ventura E, Dutt M, Elliott P, Fitzgerald DC, Rostami A. Oral resveratrol reduces neuronal damage in a model of multiple sclerosis. J Neuroophthalmol. 2010 Dec; 30(4):328-39. PMID: 21107122.
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    78. Zhou F, Zhang GX, Rostami A. 3G11 expression in CD4+ T cell-mediated autoimmunity and immune tolerance. Int Immunopharmacol. 2011 May; 11(5):593-6. PMID: 21084064.
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    79. Xu H, Yan Y, Williams MS, Carey GB, Yang J, Li H, Zhang GX, Rostami A. MS4a4B, a CD20 homologue in T cells, inhibits T cell propagation by modulation of cell cycle. PLoS One. 2010; 5(11):e13780. PMID: 21072172.
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    80. Yan Y, Zhang GX, Gran B, Fallarino F, Yu S, Li H, Cullimore ML, Rostami A, Xu H. IDO upregulates regulatory T cells via tryptophan catabolite and suppresses encephalitogenic T cell responses in experimental autoimmune encephalomyelitis. J Immunol. 2010 Nov 15; 185(10):5953-61. PMID: 20944000.
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    81. Li H, Nourbakhsh B, Ciric B, Zhang GX, Rostami A. Neutralization of IL-9 ameliorates experimental autoimmune encephalomyelitis by decreasing the effector T cell population. J Immunol. 2010 Oct 1; 185(7):4095-100. PMID: 20805418.
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    82. Yang J, Yan Y, Ciric B, Yu S, Guan Y, Xu H, Rostami A, Zhang GX. Evaluation of bone marrow- and brain-derived neural stem cells in therapy of central nervous system autoimmunity. Am J Pathol. 2010 Oct; 177(4):1989-2001. PMID: 20724590.
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    83. Zhao Z, Ciric B, Yu S, Zhang GX, Rostami A. Targeting ganglioside epitope 3G11 on the surface of CD4+ T cells suppresses EAE by altering the Treg/Th17 cell balance. Int Immunol. 2010 Oct; 22(10):817-26. PMID: 20679513.
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    84. Zhao Z, Ciric B, Yu S, Li H, Yang J, Kamoun M, Zhang GX, Rostami A. Expression of 3G11 epitope defines subpopulations of regulatory T cells with different suppressive potency. J Neurol Sci. 2010 Aug 15; 295(1-2):66-74. PMID: 20621800.
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    85. O'Brien K, Fitzgerald D, Rostami A, Gran B. The TLR7 agonist, imiquimod, increases IFN-beta production and reduces the severity of experimental autoimmune encephalomyelitis. J Neuroimmunol. 2010 Apr 15; 221(1-2):107-11. PMID: 20138374.
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    86. El-behi M, Rostami A, Ciric B. Current views on the roles of Th1 and Th17 cells in experimental autoimmune encephalomyelitis. J Neuroimmune Pharmacol. 2010 Jun; 5(2):189-97. PMID: 20107924.
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    87. O'Brien K, Gran B, Rostami A. T-cell based immunotherapy in experimental autoimmune encephalomyelitis and multiple sclerosis. Immunotherapy. 2010 Jan; 2(1):99-115. PMID: 20231863.
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    88. Li H, Rostami A. IL-9: basic biology, signaling pathways in CD4+ T cells and implications for autoimmunity. J Neuroimmune Pharmacol. 2010 Jun; 5(2):198-209. PMID: 20020328.
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    89. Phillips SM, Bhopale MK, Hilliard B, Zekavat SA, Ali MA, Rostami A. Suppression of murine experimental autoimmune encephalomyelitis by interleukin-2 receptor targeted fusion toxin, DAB(389)IL-2. Cell Immunol. 2010; 261(2):144-52. PMID: 20042183.
      Citations:    
    90. Dutt M, Tabuena P, Ventura E, Rostami A, Shindler KS. Timing of corticosteroid therapy is critical to prevent retinal ganglion cell loss in experimental optic neuritis. Invest Ophthalmol Vis Sci. 2010 Mar; 51(3):1439-45. PMID: 19892867.
      Citations:    
    91. Yang J, Jiang Z, Fitzgerald DC, Ma C, Yu S, Li H, Zhao Z, Li Y, Ciric B, Curtis M, Rostami A, Zhang GX. Adult neural stem cells expressing IL-10 confer potent immunomodulation and remyelination in experimental autoimmune encephalitis. J Clin Invest. 2009 Dec; 119(12):3678-91. PMID: 19884657.
      Citations:    
    92. El-behi M, Ciric B, Yu S, Zhang GX, Fitzgerald DC, Rostami A. Differential effect of IL-27 on developing versus committed Th17 cells. J Immunol. 2009 Oct 15; 183(8):4957-67. PMID: 19786534.
      Citations:    
    93. Ciric B, El-behi M, Cabrera R, Zhang GX, Rostami A. IL-23 drives pathogenic IL-17-producing CD8+ T cells. J Immunol. 2009 May 1; 182(9):5296-305. PMID: 19380776.
      Citations:    
    94. Jiang Z, Li H, Fitzgerald DC, Zhang GX, Rostami A. MOG(35-55) i.v suppresses experimental autoimmune encephalomyelitis partially through modulation of Th17 and JAK/STAT pathways. Eur J Immunol. 2009 Mar; 39(3):789-99. PMID: 19224632.
      Citations:    
    95. Fitzgerald DC, Rostami A. Therapeutic potential of IL-27 in multiple sclerosis? Expert Opin Biol Ther. 2009 Feb; 9(2):149-60. PMID: 19236245.
      Citations:    
    96. Li H, Ciric B, Yang J, Xu H, Fitzgerald DC, Elbehi M, Fonseca-Kelly Z, Yu S, Zhang GX, Rostami A. Intravenous tolerance modulates macrophage classical activation and antigen presentation in experimental autoimmune encephalomyelitis. J Neuroimmunol. 2009 Mar 31; 208(1-2):54-60. PMID: 19187972.
      Citations:    
    97. Xu H, Zhang GX, Ciric B, Rostami A. IDO: a double-edged sword for T(H)1/T(H)2 regulation. Immunol Lett. 2008 Nov 16; 121(1):1-6. PMID: 18824197.
      Citations:    
    98. Yang J, Rostami A, Zhang GX. Cellular remyelinating therapy in multiple sclerosis. J Neurol Sci. 2009 Jan 15; 276(1-2):1-5. PMID: 18814888.
      Citations:    
    99. Marek R, Caruso M, Rostami A, Grinspan JB, Das Sarma J. Magnetic cell sorting: a fast and effective method of concurrent isolation of high purity viable astrocytes and microglia from neonatal mouse brain tissue. J Neurosci Methods. 2008 Oct 30; 175(1):108-18. PMID: 18786564.
      Citations:    
    100. Li H, Zhang GX, Chen Y, Xu H, Fitzgerald DC, Zhao Z, Rostami A. CD11c+CD11b+ dendritic cells play an important role in intravenous tolerance and the suppression of experimental autoimmune encephalomyelitis. J Immunol. 2008 Aug 15; 181(4):2483-93. PMID: 18684939.
      Citations:    
    101. Touil T, Ciric B, Ventura E, Shindler KS, Gran B, Rostami A. Bowman-Birk inhibitor suppresses autoimmune inflammation and neuronal loss in a mouse model of multiple sclerosis. J Neurol Sci. 2008 Aug 15; 271(1-2):191-202. PMID: 18544456.
      Citations:    
    102. Shindler KS, Ventura E, Dutt M, Rostami A. Inflammatory demyelination induces axonal injury and retinal ganglion cell apoptosis in experimental optic neuritis. Exp Eye Res. 2008 Sep; 87(3):208-13. PMID: 18653182.
      Citations:    
    103. Guan Y, Yu S, Zhao Z, Ciric B, Zhang GX, Rostami A. Antigen presenting cells treated in vitro by macrophage colony-stimulating factor and autoantigen protect mice from autoimmunity. J Neuroimmunol. 2007 Dec; 192(1-2):68-78. PMID: 18006080.
      Citations:    
    104. Fitzgerald DC, Zhang GX, El-Behi M, Fonseca-Kelly Z, Li H, Yu S, Saris CJ, Gran B, Ciric B, Rostami A. Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells. Nat Immunol. 2007 Dec; 8(12):1372-9. PMID: 17994023.
      Citations:    
    105. Li Y, Chu N, Hu A, Gran B, Rostami A, Zhang GX. Inducible IL-23p19 expression in human microglia via p38 MAPK and NF-kappaB signal pathways. Exp Mol Pathol. 2008 Feb; 84(1):1-8. PMID: 18054783.
      Citations:    
    106. Fitzgerald DC, Ciric B, Touil T, Harle H, Grammatikopolou J, Das Sarma J, Gran B, Zhang GX, Rostami A. Suppressive effect of IL-27 on encephalitogenic Th17 cells and the effector phase of experimental autoimmune encephalomyelitis. J Immunol. 2007 Sep 1; 179(5):3268-75. PMID: 17709543.
      Citations:    
    107. Shindler KS, Ventura E, Rex TS, Elliott P, Rostami A. SIRT1 activation confers neuroprotection in experimental optic neuritis. Invest Ophthalmol Vis Sci. 2007 Aug; 48(8):3602-9. PMID: 17652729.
      Citations:    
    108. Phillips SM, Bhopale MK, Constantinescu CS, Ciric B, Hilliard B, Ventura E, Lavi E, Rostami A. Effect of DAB(389)IL-2 immunotoxin on the course of experimental autoimmune encephalomyelitis in Lewis rats. J Neurol Sci. 2007 Dec 15; 263(1-2):59-69. PMID: 17603081.
      Citations:    
    109. Cheng X, Zhao Z, Ventura E, Gran B, Shindler KS, Rostami A. The PD-1/PD-L pathway is up-regulated during IL-12-induced suppression of EAE mediated by IFN-gamma. J Neuroimmunol. 2007 Apr; 185(1-2):75-86. PMID: 17320975.
      Citations:    
    110. Touil T, Fitzgerald D, Zhang GX, Rostami A, Gran B. Cutting Edge: TLR3 stimulation suppresses experimental autoimmune encephalomyelitis by inducing endogenous IFN-beta. J Immunol. 2006 Dec 1; 177(11):7505-9. PMID: 17114417.
      Citations:    
    111. Shindler KS, Guan Y, Ventura E, Bennett J, Rostami A. Retinal ganglion cell loss induced by acute optic neuritis in a relapsing model of multiple sclerosis. Mult Scler. 2006 Oct; 12(5):526-32. PMID: 17086896.
      Citations:    
    112. Li Y, Chu N, Hu A, Gran B, Rostami A, Zhang GX. Increased IL-23p19 expression in multiple sclerosis lesions and its induction in microglia. Brain. 2007 Feb; 130(Pt 2):490-501. PMID: 17003070.
      Citations:    
    113. Li Y, Chu N, Rostami A, Zhang GX. Dendritic cells transduced with SOCS-3 exhibit a tolerogenic/DC2 phenotype that directs type 2 Th cell differentiation in vitro and in vivo. J Immunol. 2006 Aug 1; 177(3):1679-88. PMID: 16849477.
      Citations:    
    114. Zhang GX, Yu S, Calida D, Zhao Z, Gran B, Kamoun M, Rostami A. Loss of the surface antigen 3G11 characterizes a distinct population of anergic/regulatory T cells in experimental autoimmune encephalomyelitis. J Immunol. 2006 Mar 15; 176(6):3366-73. PMID: 16517704.
      Citations:    
    115. Zhang GX, Yu S, Gran B, Rostami A. Glucosamine abrogates the acute phase of experimental autoimmune encephalomyelitis by induction of Th2 response. J Immunol. 2005 Dec 1; 175(11):7202-8. PMID: 16301624.
      Citations:    
    116. Constantinescu CS, Tani M, Ransohoff RM, Wysocka M, Hilliard B, Fujioka T, Murphy S, Tighe PJ, Das Sarma J, Trinchieri G, Rostami A. Astrocytes as antigen-presenting cells: expression of IL-12/IL-23. J Neurochem. 2005 Oct; 95(2):331-40. PMID: 16086689.
      Citations:    
    117. Li J, Gran B, Zhang GX, Rostami A, Kamoun M. IL-27 subunits and its receptor (WSX-1) mRNAs are markedly up-regulated in inflammatory cells in the CNS during experimental autoimmune encephalomyelitis. J Neurol Sci. 2005 May 15; 232(1-2):3-9. PMID: 15850576.
      Citations:    
    118. Zhang GX, Yu S, Li Y, Ventura ES, Gran B, Rostami A. A paradoxical role of APCs in the induction of intravenous tolerance in experimental autoimmune encephalomyelitis. J Neuroimmunol. 2005 Apr; 161(1-2):101-12. PMID: 15748949.
      Citations:    
    119. Gran B, Chu N, Zhang GX, Yu S, Li Y, Chen XH, Kamoun M, Rostami A. Early administration of IL-12 suppresses EAE through induction of interferon-gamma. J Neuroimmunol. 2004 Nov; 156(1-2):123-31. PMID: 15465603.
      Citations:    
    120. Zhang GX, Yu S, Gran B, Li J, Calida D, Ventura E, Chen X, Rostami A. T cell and antibody responses in remitting-relapsing experimental autoimmune encephalomyelitis in (C57BL/6 x SJL) F1 mice. J Neuroimmunol. 2004 Mar; 148(1-2):1-10. PMID: 14975581.
      Citations:    
    121. Gran B, Zhang GX, Rostami A. Role of the IL-12/IL-23 system in the regulation of T-cell responses in central nervous system inflammatory demyelination. Crit Rev Immunol. 2004; 24(2):111-28. PMID: 15581393.
      Citations:    
    122. Li J, Gran B, Zhang GX, Ventura ES, Siglienti I, Rostami A, Kamoun M. Differential expression and regulation of IL-23 and IL-12 subunits and receptors in adult mouse microglia. J Neurol Sci. 2003 Nov 15; 215(1-2):95-103. PMID: 14568135.
      Citations:    
    123. Zhang GX, Yu S, Gran B, Li J, Siglienti I, Chen X, Calida D, Ventura E, Kamoun M, Rostami A. Role of IL-12 receptor beta 1 in regulation of T cell response by APC in experimental autoimmune encephalomyelitis. J Immunol. 2003 Nov 1; 171(9):4485-92. PMID: 14568921.
      Citations:    
    124. Nemoto H, Bhopale MK, Constantinescu CS, Schotland D, Rostami A. Skeletal muscle myosin is the autoantigen for experimental autoimmune myositis. Exp Mol Pathol. 2003 Jun; 74(3):238-43. PMID: 12782010.
      Citations:    
    125. Zhang GX, Gran B, Yu S, Li J, Siglienti I, Chen X, Kamoun M, Rostami A. Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-beta 2-deficient mice: IL-12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system. J Immunol. 2003 Feb 15; 170(4):2153-60. PMID: 12574388.
      Citations:    
    126. Gran B, Zhang GX, Yu S, Li J, Chen XH, Ventura ES, Kamoun M, Rostami A. IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination. J Immunol. 2002 Dec 15; 169(12):7104-10. PMID: 12471147.
      Citations:    
    127. Horie T, Shen Y, Kajino K, Gaubin M, Bonomi G, Mani JC, Berezov A, Piatier-Tonneau D, Guardiola J, Hillard B, Rostami A, Greene M, Murali R. Study of disabling T-cell activation and inhibiting T-cell-mediated immunopathology reveals a possible inverse agonist activity of CD4 peptidomimetics. Exp Mol Pathol. 2002 Oct; 73(2):93-103. PMID: 12231211.
      Citations:    
    128. Zhang GX, Li J, Ventura E, Rostami A. Parenchymal microglia of naïve adult C57BL/6J mice express high levels of B7.1, B7.2, and MHC class II. Exp Mol Pathol. 2002 Aug; 73(1):35-45. PMID: 12127052.
      Citations:    
    129. Zhang GX, Xu H, Kishi M, Calida D, Rostami A. The role of IL-12 in the induction of intravenous tolerance in experimental autoimmune encephalomyelitis. J Immunol. 2002 Mar 1; 168(5):2501-7. PMID: 11859144.
      Citations:    
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