Thomas Jefferson University

Bernard Lopez

TitleAdjunct Faculty
InstitutionThomas Jefferson University
DepartmentInstitute for Emerging Health
Address901 Walnut Street
Philadelphia PA 19107
Phone215-503-6764
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    Collapse Overview 
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    Society Memberships:

    American College of Emergency Physicians
    American Academy of Emergency Medicine
    Society for Academic Emergency Medicine
    Council of Residency Directors in Emergency Medicine
    American Medical Association

    Committee Memberships:

    American College of Emergency Physicians, Research Forum Committee

    Society for Academic Emergency Medicine, Faculty Development Committee



    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Casten R, Kelley M, Lawal H, Lopez BL, Parks S, Perchiniak E, Rovner B. Inspiring Undergraduate Student Training in Alzheimer's Research (USTAR): Training the Next Generation of Aging Scientists. J Am Geriatr Soc. 2025 Mar; 73(3):894-899. PMID: 39953864.
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    2. Gan L, Zhao J, Yao P, Christopher TA, Lopez B, Lau WB, Koch W, Gao E, Ma X, Wang Y. Adipocyte-derived small extracellular vesicles exacerbate diabetic ischemic heart injury by promoting oxidative stress and mitochondrial-mediated cardiomyocyte apoptosis. Redox Biol. 2025 02; 79:103443. PMID: 39740363.
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    3. Qiu G, Papanagnou D, Lopez B. Curriculum Mapping to Enhance Antiracism Education in an Undergraduate Medical Education Program. Cureus. 2024 Jun; 16(6):e62089. PMID: 38863773.
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    4. Du Y, Duan Y, Zhao J, Liu C, Zhang Z, Zhang J, Meng Z, Wang X, Lau WB, Xie D, Lopez BL, Christopher TA, Gao E, Koch WW, Liu H, Liu D, Ma XL, Gu G, Wang Y. Dysfunctional APPL1-Mediated Epigenetic Regulation in Diabetic Vascular Injury. Arterioscler Thromb Vasc Biol. 2023 12; 43(12):e491-e508. PMID: 37795615.
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    5. Meng Z, Liang B, Wu Y, Liu C, Wang H, Du Y, Gan L, Gao E, Lau WB, Christopher TA, Lopez BL, Koch WJ, Ma X, Zhao F, Wang Y, Zhao J. Hypoadiponectinemia-induced upregulation of microRNA449b downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury in diabetic mice. J Mol Cell Cardiol. 2023 09; 182:1-14. PMID: 37437402.
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    6. Meng Z, Zhang Z, Zhao J, Liu C, Yao P, Zhang L, Xie D, Lau WB, Tsukuda J, Christopher TA, Lopez B, Zhu D, Liu D, Zhang JR, Gao E, Ischiropoulos H, Koch W, Ma X, Wang Y. Nitrative Modification of Caveolin-3: A Novel Mechanism of Cardiac Insulin Resistance and a Potential Therapeutic Target Against Ischemic Heart Failure in Prediabetic Animals. Circulation. 2023 04 11; 147(15):1162-1179. PMID: 36883479.
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    7. Salhi BA, Zeidan A, Stehman CR, Kleinschmidt S, Liu EL, Bascombe K, Preston-Suni K, White MH, Druck J, Lopez BL, Samuels-Kalow ME. Structural competency in emergency medical education: A scoping review and operational framework. AEM Educ Train. 2022 Jun; 6(Suppl 1):S13-S22. PMID: 35783075.
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    8. Zhu D, Zhang Z, Zhao J, Liu D, Gan L, Lau WB, Xie D, Meng Z, Yao P, Tsukuda J, Christopher TA, Lopez BL, Gao E, Koch WJ, Wang Y, Ma XL. Targeting Adiponectin Receptor 1 Phosphorylation Against Ischemic Heart Failure. Circ Res. 2022 07 08; 131(2):e34-e50. PMID: 35611695.
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    9. Yan Z, Wang C, Meng Z, Gan L, Guo R, Liu J, Bond Lau W, Xie D, Zhao J, Lopez BL, Christopher TA, Naik UP, Ma X, Wang Y. C1q/TNF-Related Protein 3 Prevents Diabetic Retinopathy via AMPK-Dependent Stabilization of Blood-Retinal Barrier Tight Junctions. Cells. 2022 02 23; 11(5). PMID: 35269401.
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    10. Liu D, Gu G, Gan L, Yan W, Zhang Z, Yao P, Zhu D, Lau WB, Xie D, Wu S, Meng Z, Tsukuda J, Christopher T, Lopez B, Zhao J, Gao E, Koch W, Ma XL, Wang Y. Identification of a CTRP9 C-Terminal polypeptide capable of enhancing bone-derived mesenchymal stem cell cardioprotection through promoting angiogenic exosome production. Redox Biol. 2021 05; 41:101929. PMID: 33714738.
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    11. Xie Y, Meng Z, Gao J, Liu C, Wang J, Guo R, Zhao J, Lopez B, Christopher T, Lee D, Ma X, Wang Y. C1q Complement/Tumor Necrosis Factor-Associated Proteins in Cardiovascular Disease and COVID-19. Proteomes. 2021 Mar 01; 9(1). PMID: 33804408.
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    12. Liu J, Meng Z, Gan L, Guo R, Gao J, Liu C, Zhu D, Liu D, Zhang L, Zhang Z, Xie D, Jiao X, Lau WB, Lopez BL, Christopher TA, Ma X, Cao J, Wang Y. C1q/TNF-related protein 5 contributes to diabetic vascular endothelium dysfunction through promoting Nox-1 signaling. Redox Biol. 2020 07; 34:101476. PMID: 32122792.
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    13. Gan L, Xie D, Liu J, Bond Lau W, Christopher TA, Lopez B, Zhang L, Gao E, Koch W, Ma XL, Wang Y. Small Extracellular Microvesicles Mediated Pathological Communications Between Dysfunctional Adipocytes and Cardiomyocytes as a Novel Mechanism Exacerbating Ischemia/Reperfusion Injury in Diabetic Mice. Circulation. 2020 03 24; 141(12):968-983. PMID: 31918577.
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    14. Xie D, Zhao J, Guo R, Jiao L, Zhang Y, Lau WB, Lopez B, Christopher T, Gao E, Cao J, Ma X, Wang Y. Sevoflurane Pre-conditioning Ameliorates Diabetic Myocardial Ischemia/Reperfusion Injury Via Differential Regulation of p38 and ERK. Sci Rep. 2020 01 08; 10(1):23. PMID: 31913350.
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    15. Pierce AE, Moreno-Walton L, Boatright D, Moll JL, Hicks MN, Druck J, Lopez BL, Oral E, Heron SL. Advancing Diversity and Inclusion: An Organized Approach Through a Medical Specialty Academy. AEM Educ Train. 2020 Feb; 4(Suppl 1):S40-S46. PMID: 32072106.
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    16. Salhi BA, Tsai JW, Druck J, Ward-Gaines J, White MH, Lopez BL. Toward Structural Competency in Emergency Medical Education. AEM Educ Train. 2020 Feb; 4(Suppl 1):S88-S97. PMID: 32072112.
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    17. Du Y, Wang X, Li L, Hao W, Zhang H, Li Y, Qin Y, Nie S, Christopher TA, Lopez BL, Lau WB, Wang Y, Ma XL, Wei Y. miRNA-Mediated Suppression of a Cardioprotective Cardiokine as a Novel Mechanism Exacerbating Post-MI Remodeling by Sleep Breathing Disorders. Circ Res. 2020 01 17; 126(2):212-228. PMID: 31694459.
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    18. Fernandez C, Lopez BL, Kushner M, Leiby BE, Den RB. Overemphasis of Step 1 Scores May Affect Application Pool Diversity in Radiation Oncology. Pract Radiat Oncol. 2020 Jan - Feb; 10(1):e3-e7. PMID: 31369886.
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    19. Guo R, Gan L, Lau WB, Yan Z, Xie D, Gao E, Christopher TA, Lopez BL, Ma X, Wang Y. Withaferin A Prevents Myocardial Ischemia/Reperfusion Injury by Upregulating AMP-Activated Protein Kinase-Dependent B-Cell Lymphoma2 Signaling. Circ J. 2019 07 25; 83(8):1726-1736. PMID: 31217391.
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    20. Zeidan AJ, Khatri UG, Aysola J, Shofer FS, Mamtani M, Scott KR, Conlon LW, Lopez BL. Implicit Bias Education and Emergency Medicine Training: Step One? Awareness. AEM Educ Train. 2019 Jan; 3(1):81-85. PMID: 30680351.
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    21. Yan Z, Guo R, Gan L, Lau WB, Cao X, Zhao J, Ma X, Christopher TA, Lopez BL, Wang Y. Withaferin A inhibits apoptosis via activated Akt-mediated inhibition of oxidative stress. Life Sci. 2018 Oct 15; 211:91-101. PMID: 30213729.
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    22. Hurwitz A, Massone R, Lopez BL. Acquired Bleeding Disorders. Hematol Oncol Clin North Am. 2017 12; 31(6):1123-1145. PMID: 29078927.
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    23. Lovett PB, Sule HP, Lopez BL. Sickle Cell Disease in the Emergency Department. Hematol Oncol Clin North Am. 2017 12; 31(6):1061-1079. PMID: 29078924.
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    24. Samuels EA, Boatright D, Sanchez LD, Heron SL, Liferidge AT, Wilson T, Pierce A, Landry A, Moreno-Walton L, Druck J, Moll J, Lopez BL. Clinical Vignettes Inadequate to Assess Impact of Implicit Bias: Concerning Limitations of a Systematic Review. Acad Emerg Med. 2017 12; 24(12):1531-1532. PMID: 28981996.
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    25. Madsen TE, Linden JA, Rounds K, Hsieh YH, Lopez BL, Boatright D, Garg N, Heron SL, Jameson A, Kass D, Lall MD, Melendez AM, Scheulen JJ, Sethuraman KN, Westafer LM, Safdar B. Current Status of Gender and Racial/Ethnic Disparities Among Academic Emergency Medicine Physicians. Acad Emerg Med. 2017 10; 24(10):1182-1192. PMID: 28779488.
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    26. Liu GZ, Liang B, Lau WB, Wang Y, Zhao J, Li R, Wang X, Yuan Y, Lopez BL, Christopher TA, Xiao C, Ma XL, Wang Y. High glucose/High Lipids impair vascular adiponectin function via inhibition of caveolin-1/AdipoR1 signalsome formation. Free Radic Biol Med. 2015 Dec; 89:473-85. PMID: 26453924.
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    27. Yuan Y, Lau WB, Su H, Sun Y, Yi W, Du Y, Christopher T, Lopez B, Wang Y, Ma XL. C1q-TNF-related protein-9, a novel cardioprotetcive cardiokine, requires proteolytic cleavage to generate a biologically active globular domain isoform. Am J Physiol Endocrinol Metab. 2015 May 15; 308(10):E891-8. PMID: 25783894.
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    28. Hasegawa K, Tsugawa Y, Lopez BL, Smithline HA, Sullivan AF, Camargo CA. Body mass index and risk of hospitalization among adults presenting with asthma exacerbation to the emergency department. Ann Am Thorac Soc. 2014 Nov; 11(9):1439-44. PMID: 25314160.
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    29. Lovett PB, Sule HP, Lopez BL. Sickle cell disease in the emergency department. Emerg Med Clin North Am. 2014 Aug; 32(3):629-47. PMID: 25060254.
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    30. Lovett PB, Massone RJ, Holmes MN, Hall RV, Lopez BL. Rapid response team activations within 24?hours of admission from the emergency department: an innovative approach for performance improvement. Acad Emerg Med. 2014 Jun; 21(6):667-72. PMID: 25039551.
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    31. Hurwitz A, Massone R, Lopez BL. Acquired bleeding disorders. Emerg Med Clin North Am. 2014 Aug; 32(3):691-713. PMID: 25060257.
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    32. Lau WB, Zhang Y, Zhao J, Liu B, Wang X, Yuan Y, Christopher TA, Lopez B, Gao E, Koch WJ, Ma XL, Wang Y. Lymphotoxin-a is a novel adiponectin expression suppressor following myocardial ischemia/reperfusion. Am J Physiol Endocrinol Metab. 2013 Mar 15; 304(6):E661-7. PMID: 23360826.
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    33. Shin NC, Ramoska EA, Garg M, Rowh A, Nyce D, Deroos F, Carter M, Hall RV, Lopez BL. Google Internet searches on residency applicants do not facilitate the ranking process. J Emerg Med. 2013 May; 44(5):995-8. PMID: 23351574.
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    34. Estreicher M, Portale J, Lopez B. Aortic dissection presenting as gait disturbance: a case report. Am J Emerg Med. 2013 Jan; 31(1):269.e1-2. PMID: 22742952.
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    35. Zheng Q, Yuan Y, Yi W, Lau WB, Wang Y, Wang X, Sun Y, Lopez BL, Christopher TA, Peterson JM, Wong GW, Yu S, Yi D, Ma XL. C1q/TNF-related proteins, a family of novel adipokines, induce vascular relaxation through the adiponectin receptor-1/AMPK/eNOS/nitric oxide signaling pathway. Arterioscler Thromb Vasc Biol. 2011 Nov; 31(11):2616-23. PMID: 21836066.
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    36. Rodriguez F, Lopez B, Perez C, Fenoy FJ, Hernandez I, Stec DE, Li Volti G, Salom MG. Chronic tempol treatment attenuates the renal hemodynamic effects induced by a heme oxygenase inhibitor in streptozotocin diabetic rats. Am J Physiol Regul Integr Comp Physiol. 2011 Nov; 301(5):R1540-8. PMID: 21849637.
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    37. Wang XL, Lau WB, Yuan YX, Wang YJ, Yi W, Christopher TA, Lopez BL, Liu HR, Ma XL. Methylglyoxal increases cardiomyocyte ischemia-reperfusion injury via glycative inhibition of thioredoxin activity. Am J Physiol Endocrinol Metab. 2010 Aug; 299(2):E207-14. PMID: 20460580.
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    38. Yuan Y, Jiao X, Lau WB, Wang Y, Christopher TA, Lopez BL, Ramachandrarao SP, Tao L, Ma XL. Thioredoxin glycation: A novel posttranslational modification that inhibits its antioxidant and organ protective actions. Free Radic Biol Med. 2010 Aug 01; 49(3):332-8. PMID: 20416371.
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    39. Li R, Xu M, Wang X, Wang Y, Lau WB, Yuan Y, Yi W, Wei X, Lopez BL, Christopher TA, Wang XM, Ma XL. Reduced vascular responsiveness to adiponectin in hyperlipidemic rats--mechanisms and significance. J Mol Cell Cardiol. 2010 Sep; 49(3):508-15. PMID: 20303976.
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    40. Chen G, Lai W, Liu F, Mao Q, Tu F, Wen J, Xiao H, Zhang JC, Zhu T, Chen B, Hu ZY, Li RM, Liang Z, Nie H, Yan H, Yang BX, Du Q, Huang WX, Jiang YW, Kwan AS, Song L, Wu CM, Xiang T, Xu HW, Lau WB, Song HB, Wen CB, Yao ZH, Zhang L, Zeng J, Dai YE, Lopez BL, Zheng JQ, Zhou J, Christopher TA, Ma XL, Yu H, Xu LL, Guo Q, Song ZP, Volinn E, Kryger K, Cao Y, Ge H, Liu H, Luo CZ, Tao W, Zuo YX, Liu J. The dragon strikes: lessons from the Wenchuan earthquake. Anesth Analg. 2010 Mar 01; 110(3):908-15. PMID: 20185667.
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    41. Nie H, Tang SY, Lau WB, Zhang JC, Jiang YW, Lopez BL, Ma XL, Cao Y, Christopher TA. Triage during the week of the Sichuan earthquake: a review of utilized patient triage, care, and disposition procedures. Injury. 2011 May; 42(5):515-20. PMID: 20153857.
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    42. Wang Y, Tao L, Yuan Y, Lau WB, Li R, Lopez BL, Christopher TA, Tian R, Ma XL. Cardioprotective effect of adiponectin is partially mediated by its AMPK-independent antinitrative action. Am J Physiol Endocrinol Metab. 2009 Aug; 297(2):E384-91. PMID: 19470831.
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    43. Wang Y, Gao E, Tao L, Lau WB, Yuan Y, Goldstein BJ, Lopez BL, Christopher TA, Tian R, Koch W, Ma XL. AMP-activated protein kinase deficiency enhances myocardial ischemia/reperfusion injury but has minimal effect on the antioxidant/antinitrative protection of adiponectin. Circulation. 2009 Feb 17; 119(6):835-44. PMID: 19188503.
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    44. Liu HR, Tao L, Gao E, Qu Y, Lau WB, Lopez BL, Christopher TA, Koch W, Yue TL, Ma XL. Rosiglitazone inhibits hypercholesterolaemia-induced myeloperoxidase upregulation--a novel mechanism for the cardioprotective effects of PPAR agonists. Cardiovasc Res. 2009 Feb 01; 81(2):344-52. PMID: 19010810.
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    45. Zhang H, Li J, Li R, Zhang Q, Ma H, Ji Q, Guo W, Wang H, Lopez BL, Christopher TA, Ma X, Gao F. Reduced cardiotropic response to insulin in spontaneously hypertensive rats: role of peroxisome proliferator-activated receptor-gamma-initiated signaling. J Hypertens. 2008 Mar; 26(3):560-9. PMID: 18300869.
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    46. Li R, Wang WQ, Zhang H, Yang X, Fan Q, Christopher TA, Lopez BL, Tao L, Goldstein BJ, Gao F, Ma XL. Adiponectin improves endothelial function in hyperlipidemic rats by reducing oxidative/nitrative stress and differential regulation of eNOS/iNOS activity. Am J Physiol Endocrinol Metab. 2007 Dec; 293(6):E1703-8. PMID: 17895290.
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    47. Salom MG, Cer?n SN, Rodriguez F, Lopez B, Hern?ndez I, Mart?nez JG, Losa AM, Fenoy FJ. Heme oxygenase-1 induction improves ischemic renal failure: role of nitric oxide and peroxynitrite. Am J Physiol Heart Circ Physiol. 2007 Dec; 293(6):H3542-9. PMID: 17890422.
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    48. Gupta MX, Silberstein SD, Young WB, Hopkins M, Lopez BL, Samsa GP. Less is not more: underutilization of headache medications in a university hospital emergency department. Headache. 2007 Sep; 47(8):1125-33. PMID: 17883517.
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    49. Li S, Jiao X, Tao L, Liu H, Cao Y, Lopez BL, Christopher TA, Ma XL. Tumor necrosis factor-alpha in mechanic trauma plasma mediates cardiomyocyte apoptosis. Am J Physiol Heart Circ Physiol. 2007 Sep; 293(3):H1847-52. PMID: 17616742.
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    50. Wang XL, Liu HR, Tao L, Liang F, Yan L, Zhao RR, Lopez BL, Christopher TA, Ma XL. Role of iNOS-derived reactive nitrogen species and resultant nitrative stress in leukocytes-induced cardiomyocyte apoptosis after myocardial ischemia/reperfusion. Apoptosis. 2007 Jul; 12(7):1209-17. PMID: 17333318.
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    51. Zhang H, Tao L, Jiao X, Gao E, Lopez BL, Christopher TA, Koch W, Ma XL. Nitrative thioredoxin inactivation as a cause of enhanced myocardial ischemia/reperfusion injury in the aging heart. Free Radic Biol Med. 2007 Jul 01; 43(1):39-47. PMID: 17561092.
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    52. Tao L, Gao E, Jiao X, Yuan Y, Li S, Christopher TA, Lopez BL, Koch W, Chan L, Goldstein BJ, Ma XL. Adiponectin cardioprotection after myocardial ischemia/reperfusion involves the reduction of oxidative/nitrative stress. Circulation. 2007 Mar 20; 115(11):1408-16. PMID: 17339545.
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    53. Yu M, Lopez B, Dos Santos EA, Falck JR, Roman RJ. Effects of 20-HETE on Na+ transport and Na+ -K+ -ATPase activity in the thick ascending loop of Henle. Am J Physiol Regul Integr Comp Physiol. 2007 Jun; 292(6):R2400-5. PMID: 17303679.
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    54. Lopez BL, Flenders P, Davis-Moon L, Corbin T, Ballas SK. Clinically significant differences in the visual analog pain scale in acute vasoocclusive sickle cell crisis. Hemoglobin. 2007; 31(4):427-32. PMID: 17994376.
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    55. Tao L, Jiao X, Gao E, Lau WB, Yuan Y, Lopez B, Christopher T, RamachandraRao SP, Williams W, Southan G, Sharma K, Koch W, Ma XL. Nitrative inactivation of thioredoxin-1 and its role in postischemic myocardial apoptosis. Circulation. 2006 Sep 26; 114(13):1395-402. PMID: 16966583.
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    56. Tao L, Gao E, Hu A, Coletti C, Wang Y, Christopher TA, Lopez BL, Koch W, Ma XL. Thioredoxin reduces post-ischemic myocardial apoptosis by reducing oxidative/nitrative stress. Br J Pharmacol. 2006 Oct; 149(3):311-8. PMID: 16921396.
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    57. Wang HC, Zhang HF, Guo WY, Su H, Zhang KR, Li QX, Yan W, Ma XL, Lopez BL, Christopher TA, Gao F. Hypoxic postconditioning enhances the survival and inhibits apoptosis of cardiomyocytes following reoxygenation: role of peroxynitrite formation. Apoptosis. 2006 Aug; 11(8):1453-60. PMID: 16761110.
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    58. Li DY, Tao L, Liu H, Christopher TA, Lopez BL, Ma XL. Role of ERK1/2 in the anti-apoptotic and cardioprotective effects of nitric oxide after myocardial ischemia and reperfusion. Apoptosis. 2006 Jun; 11(6):923-30. PMID: 16547595.
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    59. Jacobs ER, Zhu D, Gruenloh S, Lopez B, Medhora M. VEGF-induced relaxation of pulmonary arteries is mediated by endothelial cytochrome P-450 hydroxylase. Am J Physiol Lung Cell Mol Physiol. 2006 Sep; 291(3):L369-77. PMID: 16679379.
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    60. Dhanasekaran A, Al-Saghir R, Lopez B, Zhu D, Gutterman DD, Jacobs ER, Medhora M. Protective effects of epoxyeicosatrienoic acids on human endothelial cells from the pulmonary and coronary vasculature. Am J Physiol Heart Circ Physiol. 2006 Aug; 291(2):H517-31. PMID: 16617127.
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    61. Fan Q, Gao F, Zhang L, Christopher TA, Lopez BL, Ma XL. Nitrate tolerance aggravates postischemic myocardial apoptosis and impairs cardiac functional recovery after ischemia. Apoptosis. 2005 Dec; 10(6):1235-42. PMID: 16215686.
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    62. Lopez BL, Cogen JF, Kerkula L, Corbin T, Flenders P. Pulse oximetry in the adult ED patient with sickle cell. Am J Emerg Med. 2005 Jul; 23(4):429-32. PMID: 16032605.
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    63. Tao L, Liu HR, Gao F, Qu Y, Christopher TA, Lopez BL, Ma XL. Mechanical traumatic injury without circulatory shock causes cardiomyocyte apoptosis: role of reactive nitrogen and reactive oxygen species. Am J Physiol Heart Circ Physiol. 2005 Jun; 288(6):H2811-8. PMID: 15695560.
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    64. Liu HR, Gao E, Hu A, Tao L, Qu Y, Most P, Koch WJ, Christopher TA, Lopez BL, Alnemri ES, Zervos AS, Ma XL. Role of Omi/HtrA2 in apoptotic cell death after myocardial ischemia and reperfusion. Circulation. 2005 Jan 04; 111(1):90-6. PMID: 15611365.
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    65. Zhang HF, Fan Q, Qian XX, Lopez BL, Christopher TA, Ma XL, Gao F. Role of insulin in the anti-apoptotic effect of glucose-insulin-potassium in rabbits with acute myocardial ischemia and reperfusion. Apoptosis. 2004 Nov; 9(6):777-83. PMID: 15505420.
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    66. Gao F, Tao L, Yan W, Gao E, Liu HR, Lopez BL, Christopher TA, Ma XL. Early anti-apoptosis treatment reduces myocardial infarct size after a prolonged reperfusion. Apoptosis. 2004 Sep; 9(5):553-9. PMID: 15314283.
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    67. Tao L, Gao E, Bryan NS, Qu Y, Liu HR, Hu A, Christopher TA, Lopez BL, Yodoi J, Koch WJ, Feelisch M, Ma XL. Cardioprotective effects of thioredoxin in myocardial ischemia and reperfusion: role of S-nitrosation [corrected]. Proc Natl Acad Sci U S A. 2004 Aug 03; 101(31):11471-6. PMID: 15277664.
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    68. Liang F, Gao E, Tao L, Liu H, Qu Y, Christopher TA, Lopez BL, Ma XL. Critical timing of L-arginine treatment in post-ischemic myocardial apoptosis-role of NOS isoforms. Cardiovasc Res. 2004 Jun 01; 62(3):568-77. PMID: 15158149.
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    69. Liu HR, Gao F, Tao L, Yan WL, Gao E, Christopher TA, Lopez BL, Hu A, Ma XL. Antiapoptotic mechanisms of benidipine in the ischemic/reperfused heart. Br J Pharmacol. 2004 Jun; 142(4):627-34. PMID: 15172961.
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    70. Liu HR, Tao L, Gao E, Lopez BL, Christopher TA, Willette RN, Ohlstein EH, Yue TL, Ma XL. Anti-apoptotic effects of rosiglitazone in hypercholesterolemic rabbits subjected to myocardial ischemia and reperfusion. Cardiovasc Res. 2004 Apr 01; 62(1):135-44. PMID: 15023560.
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    71. Tao L, Liu HR, Gao E, Teng ZP, Lopez BL, Christopher TA, Ma XL, Batinic-Haberle I, Willette RN, Ohlstein EH, Yue TL. Antioxidative, antinitrative, and vasculoprotective effects of a peroxisome proliferator-activated receptor-gamma agonist in hypercholesterolemia. Circulation. 2003 Dec 02; 108(22):2805-11. PMID: 14610009.
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    72. Lopez BL, Davis-Moon L, Sterious W, Bulette M, Liang-Ma X, Christopher TA. The Power Infuser: a new device for rapid fluid infusion. Am J Emerg Med. 2003 Mar; 21(2):129-32. PMID: 12671814.
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    73. Lopez BL, Kreshak AA, Morris CR, Davis-Moon L, Ballas SK, Ma XL. L-arginine levels are diminished in adult acute vaso-occlusive sickle cell crisis in the emergency department. Br J Haematol. 2003 Feb; 120(3):532-4. PMID: 12580975.
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    74. Christopher TA, Lopez BL, Stillwagon JC, Gao F, Gao E, Ma XL, Ohlstein EH, Yue TL. Idoxifene causes endothelium-dependent, nitric oxide-mediated vasorelaxation in male rats. Eur J Pharmacol. 2002 Jun 20; 446(1-3):139-43. PMID: 12098595.
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    75. Gao F, Yao CL, Gao E, Mo QZ, Yan WL, McLaughlin R, Lopez BL, Christopher TA, Ma XL. Enhancement of glutathione cardioprotection by ascorbic acid in myocardial reperfusion injury. J Pharmacol Exp Ther. 2002 May; 301(2):543-50. PMID: 11961055.
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    76. Gao F, Gao E, Yue TL, Ohlstein EH, Lopez BL, Christopher TA, Ma XL. Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: the roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation. Circulation. 2002 Mar 26; 105(12):1497-502. PMID: 11914261.
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    77. Gao F, Yue TL, Shi DW, Christopher TA, Lopez BL, Ohlstein EH, Barone FC, Ma XL. p38 MAPK inhibition reduces myocardial reperfusion injury via inhibition of endothelial adhesion molecule expression and blockade of PMN accumulation. Cardiovasc Res. 2002 Feb 01; 53(2):414-22. PMID: 11827692.
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    78. Ma XL, Gao F, Nelson AH, Lopez BL, Christopher TA, Yue TL, Barone FC. Oxidative inactivation of nitric oxide and endothelial dysfunction in stroke-prone spontaneous hypertensive rats. J Pharmacol Exp Ther. 2001 Sep; 298(3):879-85. PMID: 11504780.
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    79. Gao F, Gong B, Christopher TA, Lopez BL, Karasawa A, Ma XL. Anti-apoptotic effect of benidipine, a long-lasting vasodilating calcium antagonist, in ischaemic/reperfused myocardial cells. Br J Pharmacol. 2001 Feb; 132(4):869-78. PMID: 11181428.
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    80. Ma XL, Gao F, Chen J, Christopher TA, Lopez BL, Ohlstein EH, Yue T. Endothelial protective and antishock effects of a selective estrogen receptor modulator in rats. Am J Physiol Heart Circ Physiol. 2001 Feb; 280(2):H876-84. PMID: 11158989.
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    81. Ma XL, Gao F, Yao CL, Chen J, Lopez BL, Christopher TA, Disa J, Gu JL, Ohlstein EH, Yue TL. Nitric oxide stimulatory and endothelial protective effects of idoxifene, a selective estrogen receptor modulator, in the splanchnic artery of the ovariectomized rat. J Pharmacol Exp Ther. 2000 Nov; 295(2):786-92. PMID: 11046119.
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    82. Gao F, Chen J, Lopez BL, Christopher TA, Gu J, Lysko P, Ruffolo RR, Ohlstein EH, Ma XL, Yue TL. Comparison of bisoprolol and carvedilol cardioprotection in a rabbit ischemia and reperfusion model. Eur J Pharmacol. 2000 Oct 06; 406(1):109-16. PMID: 11011041.
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    83. Gao F, Christopher TA, Lopez BL, Friedman E, Cai G, Ma XL. Mechanism of decreased adenosine protection in reperfusion injury of aging rats. Am J Physiol Heart Circ Physiol. 2000 Jul; 279(1):H329-38. PMID: 10899073.
      Citations:    
    84. Lopez BL, Davis-Moon L, Ballas SK, Ma XL. Sequential nitric oxide measurements during the emergency department treatment of acute vasoocclusive sickle cell crisis. Am J Hematol. 2000 May; 64(1):15-9. PMID: 10815782.
      Citations:    
    85. Karras DJ, Sammon ME, Terregino CA, Lopez BL, Griswold SK, Arnold GK. Clinically meaningful changes in quantitative measures of asthma severity. Acad Emerg Med. 2000 Apr; 7(4):327-34. PMID: 10805619.
      Citations:    
    86. Ma XL, Gao F, Lopez BL, Christopher TA, Vinten-Johansen J. Peroxynitrite, a two-edged sword in post-ischemic myocardial injury-dichotomy of action in crystalloid- versus blood-perfused hearts. J Pharmacol Exp Ther. 2000 Mar; 292(3):912-20. PMID: 10688604.
      Citations:    
    87. Lopez BL, Christopher TA, Griswold SK, Ma XL. Bench to bedside: nitric oxide in emergency medicine. Acad Emerg Med. 2000 Mar; 7(3):285-93. PMID: 10730840.
      Citations:    
    88. Jasper EH, Miller M, Neuburger KJ, Widder PC, Snyder JW, Lopez BL. Venomous snakebites in an urban area: what are the possibilities? Wilderness Environ Med. 2000; 11(3):168-71. PMID: 11055562.
      Citations:    
    89. Terregino CA, Lopez BL, Karras DJ, Killian AJ, Arnold GK. Endogenous mediators in emergency department patients with presumed sepsis: are levels associated with progression to severe sepsis and death? Ann Emerg Med. 2000 Jan; 35(1):26-34. PMID: 10613937.
      Citations:    
    90. Ma XL, Gao F, Liu GL, Lopez BL, Christopher TA, Fukuto JM, Wink DA, Feelisch M. Opposite effects of nitric oxide and nitroxyl on postischemic myocardial injury. Proc Natl Acad Sci U S A. 1999 Dec 07; 96(25):14617-22. PMID: 10588754.
      Citations:    
    91. Ma XL, Kumar S, Gao F, Louden CS, Lopez BL, Christopher TA, Wang C, Lee JC, Feuerstein GZ, Yue TL. Inhibition of p38 mitogen-activated protein kinase decreases cardiomyocyte apoptosis and improves cardiac function after myocardial ischemia and reperfusion. Circulation. 1999 Apr 06; 99(13):1685-91. PMID: 10190877.
      Citations:    
    92. Levitt MA, Terregino CA, Lopez BL, Celi C. Factors affecting research directors' and residents' research experience and productivity in emergency medicine training programs. Acad Emerg Med. 1999 Apr; 6(4):356-9. PMID: 10230991.
      Citations:    
    93. Terregino CA, Levitt MA, Lopez BL, Eskra BD, Arnold GK. A national profile of resident research experience. Acad Emerg Med. 1999 Apr; 6(4):351-6. PMID: 10230990.
      Citations:    
    94. Levitt MA, Terregino CA, Lopez BL, Celi C. A national profile of resident research programs in emergency medicine. Acad Emerg Med. 1999 Apr; 6(4):348-51. PMID: 10230989.
      Citations:    
    95. Liu GL, Christopher TA, Lopez BL, Gao F, Guo Y, Gao E, Knuettel K, Feelisch M, Ma XL. SP/W-5186, A cysteine-containing nitric oxide donor, attenuates postischemic myocardial injury. J Pharmacol Exp Ther. 1998 Nov; 287(2):527-37. PMID: 9808677.
      Citations:    
    96. Lopez BL, Snyder JW, Birenbaum DS, Ma XI. N-acetylcysteine enhances endothelium-dependent vasorelaxation in the isolated rat mesenteric artery. Ann Emerg Med. 1998 Oct; 32(4):405-10. PMID: 9774922.
      Citations:    
    97. Stroh R, Christopher TA, Lopez BL, Guo YP, Amico-Roxas M, Ma XL. L-propionyl carnitine, an endogenous ester in fatty acid metabolism, exerts anti-shock and endothelial protective effects in rat splanchnic ischemia-reperfusion injury. Shock. 1998 Mar; 9(3):216-22. PMID: 9525330.
      Citations:    
    98. Christopher TA, Lopez BL, Ma XL, Feuerstein GZ, Ruffolo RR, Yue TL. Effects of a hydroxylated metabolite of the beta-andrenoreceptor antagonist, carvedilol, on post-ischaemic splachnic tissue injury. Br J Pharmacol. 1998 Jan; 123(2):292-8. PMID: 9489618.
      Citations:    
    99. Ma XL, Lopez BL, Liu GL, Christopher TA, Ischiropoulos H. Peroxynitrite aggravates myocardial reperfusion injury in the isolated perfused rat heart. Cardiovasc Res. 1997 Nov; 36(2):195-204. PMID: 9463631.
      Citations:    
    100. Ma XL, Lopez BL, Liu GL, Christopher TA, Gao F, Guo Y, Feuerstein GZ, Ruffolo RR, Barone FC, Yue TL. Hypercholesterolemia impairs a detoxification mechanism against peroxynitrite and renders the vascular tissue more susceptible to oxidative injury. Circ Res. 1997 Jun; 80(6):894-901. PMID: 9168793.
      Citations:    
    101. Lopez BL, Liu GL, Christopher TA, Ma XL. Peroxynitrite, the product of nitric oxide and superoxide, causes myocardial injury in the isolated perfused rat heart. Coron Artery Dis. 1997 Mar-Apr; 8(3-4):149-53. PMID: 9237024.
      Citations:    
    102. Lopez BL, Barnett J, Ballas SK, Christopher TA, Davis-Moon L, Ma X. Nitric oxide metabolite levels in acute vaso-occlusive sickle-cell crisis. Acad Emerg Med. 1996 Dec; 3(12):1098-103. PMID: 8959162.
      Citations:    
    103. Ma XL, Lopez BL, Christopher TA, Birenbaum DS, Vinten-Johansen J. Exogenous NO inhibits basal NO release from vascular endothelium in vitro and in vivo. Am J Physiol. 1996 Nov; 271(5 Pt 2):H2045-51. PMID: 8945924.
      Citations:    
    104. Lopez BL, Griswold SK, Navek A, Urbanski L. The complete blood count and reticulocyte count--are they necessary in the evaluation of acute vasoocclusive sickle-cell crisis? Acad Emerg Med. 1996 Aug; 3(8):751-7. PMID: 8853669.
      Citations:    
    105. Ma XL, Yue TL, Lopez BL, Barone FC, Christopher TA, Ruffolo RR, Feuerstein GZ. Carvedilol, a new beta adrenoreceptor blocker and free radical scavenger, attenuates myocardial ischemia-reperfusion injury in hypercholesterolemic rabbits. J Pharmacol Exp Ther. 1996 Apr; 277(1):128-36. PMID: 8613909.
      Citations:    
    106. Comber JT, Lopez BL. Evaluation of pulse oximetry in sickle cell anemia patients presenting to the emergency department in acute vasoocclusive crisis. Am J Emerg Med. 1996 Jan; 14(1):16-8. PMID: 8630147.
      Citations:    
    107. Lopez BL, Christopher TA, Yue TL, Ruffolo R, Feuerstein GZ, Ma XL. Carvedilol, a new beta-adrenoreceptor blocker antihypertensive drug, protects against free-radical-induced endothelial dysfunction. Pharmacology. 1995 Sep; 51(3):165-73. PMID: 7501702.
      Citations:    
    108. Christopher TA, Lopez BL, Yue TL, Feuerstein GZ, Ruffolo RR, Ma XL. Carvedilol, a new beta-adrenoreceptor blocker, vasodilator and free-radical scavenger, exerts an anti-shock and endothelial protective effect in rat splanchnic ischemia and reperfusion. J Pharmacol Exp Ther. 1995 Apr; 273(1):64-71. PMID: 7714814.
      Citations:    
    109. Lopez BL. The tilt test: effect of diabetes mellitus and antihypertensive medication on normal values. J Emerg Med. 1995 Jan-Feb; 13(1):97-8. PMID: 7632290.
      Citations:    
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