Thomas Jefferson University

Christopher Snyder

TitleProfessor
InstitutionThomas Jefferson University
DepartmentMicrobiology
Address233 S. 10th Street
Philadelphia PA 19107
Phone215-503-2543
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    Collapse Research 
    Collapse research activities and funding
    F32GM072236     (SNYDER, CHRISTOPHER M)Aug 1, 2004 - Jul 31, 2007
    NIH
    The role of GMx33 in exit from the Golgi
    Role: Principal Investigator
    K22AI081866     (SNYDER, CHRISTOPHER M)Sep 1, 2010 - Jul 31, 2013
    NIH
    Maintenance of the virus-specific T cell equillibrium in chronic MCMV infection
    Role: Principal Investigator
    R03CA174979     (SNYDER, CHRISTOPHER M)Apr 1, 2013 - Mar 31, 2015
    NIH
    Synergy between BRAF inhibition, tumor-localized T cells and a persistent vaccine
    Role: Principal Investigator
    R56AI106810     (SNYDER, CHRISTOPHER M)Jul 8, 2013 - Dec 31, 2013
    NIH
    Selection of inflationary and tissue-resident T cells during MCMV infection
    Role: Principal Investigator
    R01AI106810     (SNYDER, CHRISTOPHER M)Jan 1, 2014 - Dec 31, 2019
    NIH
    Selection of inflationary and tissue-resident T cells during MCMV infection
    Role: Principal Investigator
    R01AI146235     (SNYDER, CHRISTOPHER M)Mar 11, 2020 - Feb 28, 2025
    NIH
    T cell control of MCMV and tissue-localized immune suppression
    Role: Principal Investigator
    R03AI169437     (SNYDER, CHRISTOPHER M)Feb 1, 2022 - Jan 31, 2025
    NIH
    An animal model for cytomegalovirus-induced pathology in the developing retina
    Role: Principal Investigator
    R01AR082038     (HICKOK, NOREEN J)Aug 4, 2023 - Jun 30, 2028
    NIH
    The joint environment and periprosthetic joint infection
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Snyder CM, Hoyt K, Gouglas D. An optimal mechanism to fund the development of vaccines against emerging epidemics. J Health Econ. 2023 Jul 20; 91:102795. PMID: 37480592.
      Citations:    
    2. Snyder CM, Gill SI. Good CARMA: Turning bad tumor-resident myeloid cells good with chimeric antigen receptor macrophages. Immunol Rev. 2023 Jun 09. PMID: 37295964.
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    3. Melo-Silva CR, Knudson CJ, Tang L, Kafle S, Springer LE, Choi J, Snyder CM, Wang Y, Kim SV, Sigal LJ. Multiple and Consecutive Genome Editing Using i-GONAD and Breeding Enrichment Facilitates the Production of Genetically Modified Mice. Cells. 2023 05 08; 12(9). PMID: 37174743.
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    4. Goodkin-Gold M, Kremer M, Snyder CM, Williams H. Optimal Vaccine Subsidies for Endemic Diseases. Int J Ind Organ. 2022 Apr 02; 102840. PMID: 35400771.
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    5. Wiecek W, Ahuja A, Chaudhuri E, Kremer M, Simoes Gomes A, Snyder CM, Tabarrok A, Tan BJ. Testing fractional doses of COVID-19 vaccines. Proc Natl Acad Sci U S A. 2022 02 22; 119(8). PMID: 35131899.
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    6. Smith CJ, Snyder CM. Inhibitory Molecules PD-1, CD73 and CD39 Are Expressed by CD8+ T Cells in a Tissue-Dependent Manner and Can Inhibit T Cell Responses to Stimulation. Front Immunol. 2021; 12:704862. PMID: 34335618.
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    7. Knudson CJ, Férez M, Alves-Peixoto P, Erkes DA, Melo-Silva CR, Tang L, Snyder CM, Sigal LJ. Mechanisms of Antiviral Cytotoxic CD4 T Cell Differentiation. J Virol. 2021 09 09; 95(19):e0056621. PMID: 34260270.
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    8. Castillo JC, Ahuja A, Athey S, Baker A, Budish E, Chipty T, Glennerster R, Kominers SD, Kremer M, Larson G, Lee J, Prendergast C, Snyder CM, Tabarrok A, Tan BJ, Wiecek W. Market design to accelerate COVID-19 vaccine supply. Science. 2021 03 12; 371(6534):1107-1109. PMID: 33632897.
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    9. Zhang S, Springer LE, Rao HZ, Espinosa Trethewy RG, Bishop LM, Hancock MH, Grey F, Snyder CM. Hematopoietic cell-mediated dissemination of murine cytomegalovirus is regulated by NK cells and immune evasion. PLoS Pathog. 2021 01; 17(1):e1009255. PMID: 33508041.
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    10. Ouayogodé MH, Meara E, Ho K, Snyder CM, Colla CH. Estimates of ACO savings in the presence of provider and beneficiary selection. Healthc (Amst). 2021 Jan 04; 9(1):100460. PMID: 33412439.
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    11. Snyder CM, Hoyt K, Gouglas D, Johnston T, Robinson J. Designing Pull Funding For A COVID-19 Vaccine. Health Aff (Millwood). 2020 Jul 23; 101377hlthaff202000646. PMID: 32701395.
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    12. Wilski NA, Stotesbury C, Del Casale C, Montoya B, Wong E, Sigal LJ, Snyder CM. STING Sensing of Murine Cytomegalovirus Alters the Tumor Microenvironment to Promote Antitumor Immunity. J Immunol. 2020 Apr 13. PMID: 32284333.
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    13. Stotesbury C, Alves-Peixoto P, Montoya B, Ferez M, Nair S, Snyder CM, Zhang S, Knudson CJ, Sigal LJ. a2ß1 Integrin Is Required for Optimal NK Cell Proliferation during Viral Infection but Not for Acquisition of Effector Functions or NK Cell-Mediated Virus Control. J Immunol. 2020 Feb 03. PMID: 32015010.
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    14. Snyder CM, Davis-Poynter N, Farrell HE, Allan JE, Bonnett EL, Doom CM, Hill AB. Correction: Cross-presentation of a spread-defective MCMV is sufficient to prime the majority of virus-specific CD8+ T cells. PLoS One. 2019; 14(12):e0226705. PMID: 31834917.
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    15. Smith CJ, Venturi V, Quigley MF, Turula H, Gostick E, Ladell K, Hill BJ, Himelfarb D, Quinn KM, Greenaway HY, Dang THY, Seder RA, Douek DC, Hill AB, Davenport MP, Price DA, Snyder CM. Stochastic Expansions Maintain the Clonal Stability of CD8+ T Cell Populations Undergoing Memory Inflation Driven by Murine Cytomegalovirus. J Immunol. 2020 Jan 01; 204(1):112-121. PMID: 31818981.
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    16. Wilski NA, Del Casale C, Purwin TJ, Aplin AE, Snyder CM. Murine cytomegalovirus infection of melanoma lesions delays tumor growth by recruiting and re-polarizing monocytic phagocytes in the tumor. J Virol. 2019 Aug 02. PMID: 31375579.
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    17. Wilski NA, Snyder CM. From Vaccine Vector to Oncomodulation: Understanding the Complex Interplay between CMV and Cancer. Vaccines (Basel). 2019 Jul 09; 7(3). PMID: 31323930.
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    18. Domingo-Vidal M, Whitaker-Menezes D, Martos-Rus C, Tassone P, Snyder CM, Tuluc M, Philp N, Curry J, Martinez-Outschoorn U. Cigarette Smoke Induces Metabolic Reprogramming of the Tumor Stroma in Head and Neck Squamous Cell Carcinoma. Mol Cancer Res. 2019 Jun 25. PMID: 31239287.
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    19. Zhang S, Caldeira-Dantas S, Smith CJ, Snyder CM. Persistent viral replication and the development of T-cell responses after intranasal infection by MCMV. Med Microbiol Immunol. 2019 Mar 08. PMID: 30848361.
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    20. Jensen IJ, Winborn CS, Fosdick MG, Shao P, Tremblay MM, Shan Q, Tripathy SK, Snyder CM, Xue HH, Griffith TS, Houtman JC, Badovinac VP. Polymicrobial sepsis influences NK-cell-mediated immunity by diminishing NK-cell-intrinsic receptor-mediated effector responses to viral ligands or infections. PLoS Pathog. 2018 10; 14(10):e1007405. PMID: 30379932.
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    21. Bisetto S, Whitaker-Menezes D, Wilski NA, Tuluc M, Curry J, Zhan T, Snyder CM, Martinez-Outschoorn UE, Philp NJ. Monocarboxylate Transporter 4 (MCT4) Knockout Mice Have Attenuated 4NQO Induced Carcinogenesis; A Role for MCT4 in Driving Oral Squamous Cell Cancer. Front Oncol. 2018; 8:324. PMID: 30211114.
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    22. Caldeira-Dantas S, Furmanak T, Smith C, Quinn M, Teos LY, Ertel A, Kurup D, Tandon M, Alevizos I, Snyder CM. The Chemokine Receptor CXCR3 Promotes CD8+ T Cell Accumulation in Uninfected Salivary Glands but Is Not Necessary after Murine Cytomegalovirus Infection. J Immunol. 2018 Feb 01; 200(3):1133-1145. PMID: 29288198.
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    23. Erkes DA, Wilski NA, Snyder CM. Intratumoral infection by CMV may change the tumor environment by directly interacting with tumor-associated macrophages to promote cancer immunity. Hum Vaccin Immunother. 2017 Jun 12; 1-8. PMID: 28604162.
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    24. Erkes DA, Smith CJ, Wilski NA, Caldeira-Dantas S, Mohgbeli T, Snyder CM. Virus-Specific CD8+ T Cells Infiltrate Melanoma Lesions and Retain Function Independently of PD-1 Expression. J Immunol. 2017 Apr 01; 198(7):2979-2988. PMID: 28202614.
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    25. Loo CP, Snyder CM, Hill AB. Blocking Virus Replication during Acute Murine Cytomegalovirus Infection Paradoxically Prolongs Antigen Presentation and Increases the CD8+ T Cell Response by Preventing Type I IFN-Dependent Depletion of Dendritic Cells. J Immunol. 2016 Nov 21. PMID: 27872208.
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    26. Smith CJ, Quinn M, Snyder CM. CMV-Specific CD8 T Cell Differentiation and Localization: Implications for Adoptive Therapies. Front Immunol. 2016; 7:352. PMID: 27695453.
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    27. Erkes DA, Xu G, Daskalakis C, Zurbach KA, Wilski NA, Moghbeli T, Hill AB, Snyder CM. Intratumoral Infection with Murine Cytomegalovirus Synergizes with PD-L1 Blockade to Clear Melanoma Lesions and Induce Long-term Immunity. Mol Ther. 2016 Aug; 24(8):1444-55. PMID: 27434584.
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    28. Quinn M, Erkes DA, Snyder CM. Cytomegalovirus and immunotherapy: opportunistic pathogen, novel target for cancer and a promising vaccine vector. Immunotherapy. 2016 Feb; 8(2):211-21. PMID: 26786895.
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    29. Snyder CM. Front-Line Memory T Cells Think Outside the T-box… Mostly. Immunity. 2015 Dec 15; 43(6):1030-2. PMID: 26682977.
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    30. Smith CJ, Caldeira-Dantas S, Turula H, Snyder CM. Murine CMV Infection Induces the Continuous Production of Mucosal Resident T Cells. Cell Rep. 2015 Nov 10; 13(6):1137-48. PMID: 26526996.
      Citations:    
    31. Quinn M, Turula H, Tandon M, Deslouches B, Moghbeli T, Snyder CM. Memory T cells specific for murine cytomegalovirus re-emerge after multiple challenges and recapitulate immunity in various adoptive transfer scenarios. J Immunol. 2015 Feb 15; 194(4):1726-36. PMID: 25595792.
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    32. Smith CJ, Turula H, Snyder CM. Systemic Hematogenous Maintenance of Memory Inflation by MCMV Infection. PLoS Pathog. 2014 Jul; 10(7):e1004233. PMID: 24992722.
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    33. Zurbach KA, Moghbeli T, Snyder CM. Resolving the titer of murine cytomegalovirus by plaque assay using the M2-10B4 cell line and a low viscosity overlay. Virol J. 2014; 11(1):71. PMID: 24742045.
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    34. Turula H, Smith CJ, Grey F, Zurbach KA, Snyder CM. Competition between T cells maintains clonal dominance during memory inflation induced by MCMV. Eur J Immunol. 2013 Apr; 43(5):1252-63. PMID: 23404526.
      Citations:    
    35. Farrington LA, Smith TA, Grey F, Hill AB, Snyder CM. Competition for Antigen at the Level of the APC Is a Major Determinant of Immunodominance during Memory Inflation in Murine Cytomegalovirus Infection. J Immunol. 2013 Apr 1; 190(7):3410-6. PMID: 23455500.
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    36. Snyder CM. Editorial: Once more unto the breach, dear friends: CMV reactivates when the walls come down. J Leukoc Biol. 2012 Nov; 92(5):915-8. PMID: 23118442.
      Citations:    
    37. Snyder CM. Buffered memory: a hypothesis for the maintenance of functional, virus-specific CD8(+) T cells during cytomegalovirus infection. Immunol Res. 2011 Dec; 51(2-3):195-204. PMID: 22058020.
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    38. Snyder CM, Cho KS, Bonnett EL, Allan JE, Hill AB. Sustained CD8+ T cell memory inflation after infection with a single-cycle cytomegalovirus. PLoS Pathog. 2011 Oct; 7(10):e1002295. PMID: 21998590.
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    39. Snyder CM, Begor W, Berndt ER. Economic perspectives on the advance market commitment for pneumococcal vaccines. Health Aff (Millwood). 2011 Aug; 30(8):1508-17. PMID: 21821567.
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    40. Heiser RA, Snyder CM, St Clair J, Wysocki LJ. Aborted germinal center reactions and B cell memory by follicular T cells specific for a B cell receptor V region peptide. J Immunol. 2011 Jul 1; 187(1):212-21. PMID: 21622866.
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    41. Snyder CM, Allan JE, Bonnett EL, Doom CM, Hill AB. Cross-presentation of a spread-defective MCMV is sufficient to prime the majority of virus-specific CD8+ T cells. PLoS One. 2010; 5(3):e9681. PMID: 20300633.
      Citations:    
    42. Snyder CM, Loewendorf A, Bonnett EL, Croft M, Benedict CA, Hill AB. CD4+ T cell help has an epitope-dependent impact on CD8+ T cell memory inflation during murine cytomegalovirus infection. J Immunol. 2009 Sep 15; 183(6):3932-41. PMID: 19692644.
      Citations:    
    43. Snyder CM, Cho KS, Bonnett EL, van Dommelen S, Shellam GR, Hill AB. Memory inflation during chronic viral infection is maintained by continuous production of short-lived, functional T cells. Immunity. 2008 Oct 17; 29(4):650-9. PMID: 18957267.
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    44. Mardones GA, Snyder CM, Howell KE. Cis-Golgi matrix proteins move directly to endoplasmic reticulum exit sites by association with tubules. Mol Biol Cell. 2006 Jan; 17(1):525-38. PMID: 16251359.
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    45. Snyder CM, Mardones GA, Ladinsky MS, Howell KE. GMx33 associates with the trans-Golgi matrix in a dynamic manner and sorts within tubules exiting the Golgi. Mol Biol Cell. 2006 Jan; 17(1):511-24. PMID: 16236792.
      Citations:    
    46. Snyder CM, Aviszus K, Heiser RA, Tonkin DR, Guth AM, Wysocki LJ. Activation and tolerance in CD4(+) T cells reactive to an immunoglobulin variable region. J Exp Med. 2004 Jul 5; 200(1):1-11. PMID: 15226360.
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    47. Snyder CM, Zhang X, Wysocki LJ. Negligible class II MHC presentation of B cell receptor-derived peptides by high density resting B cells. J Immunol. 2002 Apr 15; 168(8):3865-73. PMID: 11937540.
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