Brian J Bahnson
Title | Professor |
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Institution | University of Delaware |
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Department | Chemistry & Biochemistry |
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Phone | 302-831-0786 |
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vCard | Download vCard |
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Research F32GM014288 (BAHNSON, BRIAN J)Apr 1, 1992 NIH/NIGMS PROTON TUNNELING STUDIED BY SITE-SPECIFIC MUTAGENESIS Role: Principal Investigator |
| T32GM008550 (BAHNSON, BRIAN J)Jul 1, 1994 - Jun 30, 2019 NIH/NIGMS Chemistry-Biology Interface (CBI) NIH T32 Training Grant Role: Principal Investigator |
| R01HL084366 (BAHNSON, BRIAN J)Jun 15, 2007 - May 31, 2013 NIH/NHLBI Structure and Interfacial Function of Platelet Activating Factor Acetylhydrolase Role: Principal Investigator |
| T32GM133395 (BAHNSON, BRIAN J)Jul 1, 2019 - Jun 30, 2024 NIH/NIGMS Chemistry and Biology Interface (CBI) NIH T32 Training Grant Role: Principal Investigator |
| S10OD026896 (BAHNSON, BRIAN J)Jul 1, 2020 - Jun 30, 2021 NIH Macromolecular X-ray Crystallographic Data Collection System Role: Principal Investigator |
Bibliographic
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Dong M, Lauro ML, Koblish TJ, Bahnson BJ. Conformational sampling and kinetics changes across a non-Arrhenius break point in the enzyme thermolysin. Struct Dyn. 2020 Jan; 7(1):014101. PMID: 32095489.
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Chen Q, Xu S, Lu X, Boeri MV, Pepelyayeva Y, Diaz EL, Soni SD, Allaire M, Forstner MB, Bahnson BJ, Rozovsky S. 77Se NMR Probes the Protein Environment of Selenomethionine. J Phys Chem B. 2020 Jan 30; 124(4):601-616. PMID: 31846581.
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Dong M, Gonzalez TD, Klems MM, Steinberg LM, Chen W, Papoutsakis ET, Bahnson BJ. In vitro methanol production from methyl coenzyme M using the Methanosarcina barkeri MtaABC protein complex. Biotechnol Prog. 2017 May 27. PMID: 28556629.
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Lauro ML, D'Ambrosio EA, Bahnson BJ, Grimes CL. The Molecular Recognition of Muramyl Dipeptide Occurs in the Leucine-rich Repeat Domain of Nod2. ACS Infect Dis. 2016 Oct 17. PMID: 27748583.
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Klems MM, Bahnson BJ. Trafficking and Oligomeric Regulation of Platelet-Activating Factor Acetylhydrolase Type II. Enzymes. 2015; 38:55-69. PMID: 26612647.
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Gonzalez TD, Bahnson BJ. Crystal Structure and Atomic Level Analysis of Plasma PAF-AH. Enzymes. 2015; 38:95-116. PMID: 26612649.
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Kirby SD, Norris J, Sweeney R, Bahnson BJ, Cerasoli DM. A rationally designed mutant of plasma platelet-activating factor acetylhydrolase hydrolyzes the organophosphorus nerve agent soman. Biochim Biophys Acta. 2015 Dec; 1854(12):1809-15. PMID: 26343853.
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Monillas ES, Caplan JL, Thévenin AF, Bahnson BJ. Oligomeric state regulated trafficking of human platelet-activating factor acetylhydrolase type-II. Biochim Biophys Acta. 2015 May; 1854(5):469-75. PMID: 25707358.
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Nagano JM, Hsu KL, Whitby LR, Niphakis MJ, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Hodder P, Srinivasan P, Gonzalez TD, Rosen H, Bahnson BJ, Cravatt BF. Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2). Bioorg Med Chem Lett. 2013 Feb 1; 23(3):839-43. PMID: 23260346.
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Schaefer SA, Dong M, Rubenstein RP, Wilkie WA, Bahnson BJ, Thorpe C, Rozovsky S. (77)Se enrichment of proteins expands the biological NMR toolbox. J Mol Biol. 2013 Jan 23; 425(2):222-31. PMID: 23159557.
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Kirby SD, Norris JR, Richard Smith J, Bahnson BJ, Cerasoli DM. Human paraoxonase double mutants hydrolyze V and G class organophosphorus nerve agents. Chem Biol Interact. 2013 Mar 25; 203(1):181-5. PMID: 23159884.
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Nagel ZD, Meadows CW, Dong M, Bahnson BJ, Klinman JP. Active site hydrophobic residues impact hydrogen tunneling differently in a thermophilic alcohol dehydrogenase at optimal versus nonoptimal temperatures. Biochemistry. 2012 May 22; 51(20):4147-56. PMID: 22568562.
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Scott SH, Bahnson BJ. Senescence Marker Protein 30: Functional and Structural Insights to its Unknown Physiological Function. Biomol Concepts. 2011 Dec 01; 2(6):469-480. PMID: 22844387.
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Thévenin AF, Monillas ES, Winget JM, Czymmek K, Bahnson BJ. Trafficking of platelet-activating factor acetylhydrolase type II in response to oxidative stress. Biochemistry. 2011 Oct 4; 50(39):8417-26. PMID: 21882811.
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Nagel ZD, Dong M, Bahnson BJ, Klinman JP. Impaired protein conformational landscapes as revealed in anomalous Arrhenius prefactors. Proc Natl Acad Sci U S A. 2011 Jun 28; 108(26):10520-5. PMID: 21670258.
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Thévenin AF, Zony CL, Bahnson BJ, Colman RF. GST pi modulates JNK activity through a direct interaction with JNK substrate, ATF2. Protein Sci. 2011 May; 20(5):834-48. PMID: 21384452.
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Thévenin AF, Zony CL, Bahnson BJ, Colman RF. Activation by phosphorylation and purification of human c-Jun N-terminal kinase (JNK) isoforms in milligram amounts. Protein Expr Purif. 2011 Feb; 75(2):138-46. PMID: 20709173.
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Daithankar VN, Schaefer SA, Dong M, Bahnson BJ, Thorpe C. Structure of the human sulfhydryl oxidase augmenter of liver regeneration and characterization of a human mutation causing an autosomal recessive myopathy . Biochemistry. 2010 Aug 10; 49(31):6737-45. PMID: 20593814.
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Chakraborti S, Bahnson BJ. Crystal structure of human senescence marker protein 30: insights linking structural, enzymatic, and physiological functions . Biochemistry. 2010 Apr 27; 49(16):3436-44. PMID: 20329768.
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Pan YH, Bahnson BJ. Structure of a premicellar complex of alkyl sulfates with the interfacial binding surfaces of four subunits of phospholipase A2. Biochim Biophys Acta. 2010 Jul; 1804(7):1443-8. PMID: 20302975.
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Srinivasan P, Bahnson BJ. Molecular Model of Plasma PAF Acetylhydrolase-Lipoprotein Association: Insights from the Structure. Pharmaceuticals (Basel). 2010 Mar 08; 3(3):541-557. PMID: 27713267.
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Samanta U, Kirby SD, Srinivasan P, Cerasoli DM, Bahnson BJ. Crystal structures of human group-VIIA phospholipase A2 inhibited by organophosphorus nerve agents exhibit non-aged complexes. Biochem Pharmacol. 2009 Aug 15; 78(4):420-9. PMID: 19394314.
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Epstein TM, Samanta U, Kirby SD, Cerasoli DM, Bahnson BJ. Crystal structures of brain group-VIII phospholipase A2 in nonaged complexes with the organophosphorus nerve agents soman and sarin. Biochemistry. 2009 Apr 21; 48(15):3425-35. PMID: 19271773.
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Samanta U, Wilder C, Bahnson BJ. Crystallization and preliminary X-ray crystallographic analysis of human plasma platelet activating factor acetylhydrolase. Protein Pept Lett. 2009; 16(1):97-100. PMID: 19149681.
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Samanta U, Bahnson BJ. Crystal structure of human plasma platelet-activating factor acetylhydrolase: structural implication to lipoprotein binding and catalysis. J Biol Chem. 2008 Nov 14; 283(46):31617-24. PMID: 18784071.
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Pan YH, Bahnson BJ. Structural basis for bile salt inhibition of pancreatic phospholipase A2. J Mol Biol. 2007 Jun 1; 369(2):439-50. PMID: 17434532.
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Winget JM, Pan YH, Bahnson BJ. The interfacial binding surface of phospholipase A2s. Biochim Biophys Acta. 2006 Nov; 1761(11):1260-9. PMID: 16962825.
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Blamey CJ, Ceccarelli C, Naik UP, Bahnson BJ. The crystal structure of calcium- and integrin-binding protein 1: insights into redox regulated functions. Protein Sci. 2005 May; 14(5):1214-21. PMID: 15840829.
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Yu BZ, Pan YH, Janssen MJ, Bahnson BJ, Jain MK. Kinetic and structural properties of disulfide engineered phospholipase A2: insight into the role of disulfide bonding patterns. Biochemistry. 2005 Mar 8; 44(9):3369-79. PMID: 15736947.
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Bahnson BJ. Structure, function and interfacial allosterism in phospholipase A2: insight from the anion-assisted dimer. Arch Biochem Biophys. 2005 Jan 1; 433(1):96-106. PMID: 15581569.
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Bahnson BJ. An atomic-resolution mechanism of 3-hydroxy-3-methylglutaryl-CoA synthase. Proc Natl Acad Sci U S A. 2004 Nov 23; 101(47):16399-400. PMID: 15546978.
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Yeung DT, Josse D, Nicholson JD, Khanal A, McAndrew CW, Bahnson BJ, Lenz DE, Cerasoli DM. Structure/function analyses of human serum paraoxonase (HuPON1) mutants designed from a DFPase-like homology model. Biochim Biophys Acta. 2004 Oct 1; 1702(1):67-77. PMID: 15450851.
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Ceccarelli C, Liang ZX, Strickler M, Prehna G, Goldstein BM, Klinman JP, Bahnson BJ. Crystal structure and amide H/D exchange of binary complexes of alcohol dehydrogenase from Bacillus stearothermophilus: insight into thermostability and cofactor binding. Biochemistry. 2004 May 11; 43(18):5266-77. PMID: 15122892.
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Smart BP, Pan YH, Weeks AK, Bollinger JG, Bahnson BJ, Gelb MH. Inhibition of the complete set of mammalian secreted phospholipases A(2) by indole analogues: a structure-guided study. Bioorg Med Chem. 2004 Apr 1; 12(7):1737-49. PMID: 15028265.
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Tessier PM, Johnson HR, Pazhianur R, Berger BW, Prentice JL, Bahnson BJ, Sandler SI, Lenhoff AM. Predictive crystallization of ribonuclease A via rapid screening of osmotic second virial coefficients. Proteins. 2003 Feb 1; 50(2):303-11. PMID: 12486724.
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Pan YH, Yu BZ, Berg OG, Jain MK, Bahnson BJ. Crystal structure of phospholipase A2 complex with the hydrolysis products of platelet activating factor: equilibrium binding of fatty acid and lysophospholipid-ether at the active site may be mutually exclusive. Biochemistry. 2002 Dec 17; 41(50):14790-800. PMID: 12475227.
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Ceccarelli C, Grodsky NB, Ariyaratne N, Colman RF, Bahnson BJ. Crystal structure of porcine mitochondrial NADP+-dependent isocitrate dehydrogenase complexed with Mn2+ and isocitrate. Insights into the enzyme mechanism. J Biol Chem. 2002 Nov 8; 277(45):43454-62. PMID: 12207025.
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Pan YH, Yu BZ, Singer AG, Ghomashchi F, Lambeau G, Gelb MH, Jain MK, Bahnson BJ. Crystal structure of human group X secreted phospholipase A2. Electrostatically neutral interfacial surface targets zwitterionic membranes. J Biol Chem. 2002 Aug 9; 277(32):29086-93. PMID: 12161451.
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Bahnson BJ, Anderson VE, Petsko GA. Structural mechanism of enoyl-CoA hydratase: three atoms from a single water are added in either an E1cb stepwise or concerted fashion. Biochemistry. 2002 Feb 26; 41(8):2621-9. PMID: 11851409.
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D'Ordine RL, Pawlak J, Bahnson BJ, Anderson VE. Polarization of cinnamoyl-CoA substrates bound to enoyl-CoA hydratase: correlation of (13)C NMR with quantum mechanical calculations and calculation of electronic strain energy. Biochemistry. 2002 Feb 26; 41(8):2630-40. PMID: 11851410.
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Epstein TM, Yu BZ, Pan YH, Tutton SP, Maliwal BP, Jain MK, Bahnson BJ. The basis for k(cat) impairment in prophospholipase A(2) from the anion-assisted dimer structure. Biochemistry. 2001 Sep 25; 40(38):11411-22. PMID: 11560489.
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Pan YH, Epstein TM, Jain MK, Bahnson BJ. Five coplanar anion binding sites on one face of phospholipase A2: relationship to interface binding. Biochemistry. 2001 Jan 23; 40(3):609-17. PMID: 11170377.
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Jeffery CJ, Bahnson BJ, Chien W, Ringe D, Petsko GA. Crystal structure of rabbit phosphoglucose isomerase, a glycolytic enzyme that moonlights as neuroleukin, autocrine motility factor, and differentiation mediator. Biochemistry. 2000 Feb 8; 39(5):955-64. PMID: 10653639.
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Colby TD, Bahnson BJ, Chin JK, Klinman JP, Goldstein BM. Active site modifications in a double mutant of liver alcohol dehydrogenase: structural studies of two enzyme-ligand complexes. Biochemistry. 1998 Jun 30; 37(26):9295-304. PMID: 9649310.
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Bahnson BJ, Colby TD, Chin JK, Goldstein BM, Klinman JP. A link between protein structure and enzyme catalyzed hydrogen tunneling. Proc Natl Acad Sci U S A. 1997 Nov 25; 94(24):12797-802. PMID: 9371755.
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Bahnson BJ, Klinman JP. Hydrogen tunneling in enzyme catalysis. Methods Enzymol. 1995; 249:373-97. PMID: 7791619.
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D'Ordine RL, Bahnson BJ, Tonge PJ, Anderson VE. Enoyl-coenzyme A hydratase-catalyzed exchange of the alpha-protons of coenzyme A thiol esters: a model for an enolized intermediate in the enzyme-catalyzed elimination? Biochemistry. 1994 Dec 13; 33(49):14733-42. PMID: 7993901.
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Bahnson BJ, Park DH, Kim K, Plapp BV, Klinman JP. Unmasking of hydrogen tunneling in the horse liver alcohol dehydrogenase reaction by site-directed mutagenesis. Biochemistry. 1993 Jun 1; 32(21):5503-7. PMID: 8504071.
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Bahnson BJ, Anderson VE. Crotonase-catalyzed beta-elimination is concerted: a double isotope effect study. Biochemistry. 1991 Jun 18; 30(24):5894-906. PMID: 2043630.
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Anderson VE, Bahnson BJ, Wlassics ID, Walsh CT. The reaction of acetyldithio-CoA, a readily enolized analog of acetyl-CoA with thiolase from Zoogloea ramigera. J Biol Chem. 1990 Apr 15; 265(11):6255-61. PMID: 2180945.
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Bahnson BJ, Anderson VE. Isotope effects on the crotonase reaction. Biochemistry. 1989 May 16; 28(10):4173-81. PMID: 2765479.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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Year | Publications |
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1991 | 1 | 1993 | 1 | 1994 | 1 | 1995 | 1 | 1997 | 1 | 1998 | 1 | 2000 | 1 | 2001 | 2 | 2002 | 5 | 2003 | 1 | 2004 | 4 | 2005 | 3 | 2006 | 1 | 2007 | 1 | 2008 | 1 | 2009 | 3 | 2010 | 5 | 2011 | 4 | 2012 | 4 | 2015 | 4 | 2016 | 1 | 2017 | 1 | 2020 | 2 |
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