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Brian J Bahnson

TitleProfessor
InstitutionUniversity of Delaware
DepartmentChemistry & Biochemistry
Phone302-831-0786
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    Collapse Research 
    Collapse research activities and funding
    F32GM014288     (BAHNSON, BRIAN J)Apr 1, 1992
    NIH/NIGMS
    PROTON TUNNELING STUDIED BY SITE-SPECIFIC MUTAGENESIS
    Role: Principal Investigator
    T32GM008550     (BAHNSON, BRIAN J)Jul 1, 1994 - Jun 30, 2019
    NIH/NIGMS
    Chemistry-Biology Interface (CBI) NIH T32 Training Grant
    Role: Principal Investigator
    R01HL084366     (BAHNSON, BRIAN J)Jun 15, 2007 - May 31, 2013
    NIH/NHLBI
    Structure and Interfacial Function of Platelet Activating Factor Acetylhydrolase
    Role: Principal Investigator
    T32GM133395     (BAHNSON, BRIAN J)Jul 1, 2019 - Jun 30, 2024
    NIH/NIGMS
    Chemistry and Biology Interface (CBI) NIH T32 Training Grant
    Role: Principal Investigator
    S10OD026896     (BAHNSON, BRIAN J)Jul 1, 2020 - Jun 30, 2021
    NIH
    Macromolecular X-ray Crystallographic Data Collection System
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Dong M, Lauro ML, Koblish TJ, Bahnson BJ. Conformational sampling and kinetics changes across a non-Arrhenius break point in the enzyme thermolysin. Struct Dyn. 2020 Jan; 7(1):014101. PMID: 32095489.
      View in: PubMed
    2. Chen Q, Xu S, Lu X, Boeri MV, Pepelyayeva Y, Diaz EL, Soni SD, Allaire M, Forstner MB, Bahnson BJ, Rozovsky S. 77Se NMR Probes the Protein Environment of Selenomethionine. J Phys Chem B. 2020 Jan 30; 124(4):601-616. PMID: 31846581.
      View in: PubMed
    3. Dong M, Gonzalez TD, Klems MM, Steinberg LM, Chen W, Papoutsakis ET, Bahnson BJ. In vitro methanol production from methyl coenzyme M using the Methanosarcina barkeri MtaABC protein complex. Biotechnol Prog. 2017 May 27. PMID: 28556629.
      View in: PubMed
    4. Lauro ML, D'Ambrosio EA, Bahnson BJ, Grimes CL. The Molecular Recognition of Muramyl Dipeptide Occurs in the Leucine-rich Repeat Domain of Nod2. ACS Infect Dis. 2016 Oct 17. PMID: 27748583.
      View in: PubMed
    5. Klems MM, Bahnson BJ. Trafficking and Oligomeric Regulation of Platelet-Activating Factor Acetylhydrolase Type II. Enzymes. 2015; 38:55-69. PMID: 26612647.
      View in: PubMed
    6. Gonzalez TD, Bahnson BJ. Crystal Structure and Atomic Level Analysis of Plasma PAF-AH. Enzymes. 2015; 38:95-116. PMID: 26612649.
      View in: PubMed
    7. Kirby SD, Norris J, Sweeney R, Bahnson BJ, Cerasoli DM. A rationally designed mutant of plasma platelet-activating factor acetylhydrolase hydrolyzes the organophosphorus nerve agent soman. Biochim Biophys Acta. 2015 Dec; 1854(12):1809-15. PMID: 26343853.
      View in: PubMed
    8. Monillas ES, Caplan JL, Thévenin AF, Bahnson BJ. Oligomeric state regulated trafficking of human platelet-activating factor acetylhydrolase type-II. Biochim Biophys Acta. 2015 May; 1854(5):469-75. PMID: 25707358.
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    9. Nagano JM, Hsu KL, Whitby LR, Niphakis MJ, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Hodder P, Srinivasan P, Gonzalez TD, Rosen H, Bahnson BJ, Cravatt BF. Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2). Bioorg Med Chem Lett. 2013 Feb 1; 23(3):839-43. PMID: 23260346.
      View in: PubMed
    10. Schaefer SA, Dong M, Rubenstein RP, Wilkie WA, Bahnson BJ, Thorpe C, Rozovsky S. (77)Se enrichment of proteins expands the biological NMR toolbox. J Mol Biol. 2013 Jan 23; 425(2):222-31. PMID: 23159557.
      View in: PubMed
    11. Kirby SD, Norris JR, Richard Smith J, Bahnson BJ, Cerasoli DM. Human paraoxonase double mutants hydrolyze V and G class organophosphorus nerve agents. Chem Biol Interact. 2013 Mar 25; 203(1):181-5. PMID: 23159884.
      View in: PubMed
    12. Nagel ZD, Meadows CW, Dong M, Bahnson BJ, Klinman JP. Active site hydrophobic residues impact hydrogen tunneling differently in a thermophilic alcohol dehydrogenase at optimal versus nonoptimal temperatures. Biochemistry. 2012 May 22; 51(20):4147-56. PMID: 22568562.
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    13. Scott SH, Bahnson BJ. Senescence Marker Protein 30: Functional and Structural Insights to its Unknown Physiological Function. Biomol Concepts. 2011 Dec 01; 2(6):469-480. PMID: 22844387.
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    14. Thévenin AF, Monillas ES, Winget JM, Czymmek K, Bahnson BJ. Trafficking of platelet-activating factor acetylhydrolase type II in response to oxidative stress. Biochemistry. 2011 Oct 4; 50(39):8417-26. PMID: 21882811.
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    15. Nagel ZD, Dong M, Bahnson BJ, Klinman JP. Impaired protein conformational landscapes as revealed in anomalous Arrhenius prefactors. Proc Natl Acad Sci U S A. 2011 Jun 28; 108(26):10520-5. PMID: 21670258.
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    16. Thévenin AF, Zony CL, Bahnson BJ, Colman RF. GST pi modulates JNK activity through a direct interaction with JNK substrate, ATF2. Protein Sci. 2011 May; 20(5):834-48. PMID: 21384452.
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    17. Thévenin AF, Zony CL, Bahnson BJ, Colman RF. Activation by phosphorylation and purification of human c-Jun N-terminal kinase (JNK) isoforms in milligram amounts. Protein Expr Purif. 2011 Feb; 75(2):138-46. PMID: 20709173.
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    18. Daithankar VN, Schaefer SA, Dong M, Bahnson BJ, Thorpe C. Structure of the human sulfhydryl oxidase augmenter of liver regeneration and characterization of a human mutation causing an autosomal recessive myopathy . Biochemistry. 2010 Aug 10; 49(31):6737-45. PMID: 20593814.
      View in: PubMed
    19. Chakraborti S, Bahnson BJ. Crystal structure of human senescence marker protein 30: insights linking structural, enzymatic, and physiological functions . Biochemistry. 2010 Apr 27; 49(16):3436-44. PMID: 20329768.
      View in: PubMed
    20. Pan YH, Bahnson BJ. Structure of a premicellar complex of alkyl sulfates with the interfacial binding surfaces of four subunits of phospholipase A2. Biochim Biophys Acta. 2010 Jul; 1804(7):1443-8. PMID: 20302975.
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    21. Srinivasan P, Bahnson BJ. Molecular Model of Plasma PAF Acetylhydrolase-Lipoprotein Association: Insights from the Structure. Pharmaceuticals (Basel). 2010 Mar 08; 3(3):541-557. PMID: 27713267.
      View in: PubMed
    22. Samanta U, Kirby SD, Srinivasan P, Cerasoli DM, Bahnson BJ. Crystal structures of human group-VIIA phospholipase A2 inhibited by organophosphorus nerve agents exhibit non-aged complexes. Biochem Pharmacol. 2009 Aug 15; 78(4):420-9. PMID: 19394314.
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    23. Epstein TM, Samanta U, Kirby SD, Cerasoli DM, Bahnson BJ. Crystal structures of brain group-VIII phospholipase A2 in nonaged complexes with the organophosphorus nerve agents soman and sarin. Biochemistry. 2009 Apr 21; 48(15):3425-35. PMID: 19271773.
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    24. Samanta U, Wilder C, Bahnson BJ. Crystallization and preliminary X-ray crystallographic analysis of human plasma platelet activating factor acetylhydrolase. Protein Pept Lett. 2009; 16(1):97-100. PMID: 19149681.
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    25. Samanta U, Bahnson BJ. Crystal structure of human plasma platelet-activating factor acetylhydrolase: structural implication to lipoprotein binding and catalysis. J Biol Chem. 2008 Nov 14; 283(46):31617-24. PMID: 18784071.
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    26. Pan YH, Bahnson BJ. Structural basis for bile salt inhibition of pancreatic phospholipase A2. J Mol Biol. 2007 Jun 1; 369(2):439-50. PMID: 17434532.
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    27. Winget JM, Pan YH, Bahnson BJ. The interfacial binding surface of phospholipase A2s. Biochim Biophys Acta. 2006 Nov; 1761(11):1260-9. PMID: 16962825.
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    28. Blamey CJ, Ceccarelli C, Naik UP, Bahnson BJ. The crystal structure of calcium- and integrin-binding protein 1: insights into redox regulated functions. Protein Sci. 2005 May; 14(5):1214-21. PMID: 15840829.
      View in: PubMed
    29. Yu BZ, Pan YH, Janssen MJ, Bahnson BJ, Jain MK. Kinetic and structural properties of disulfide engineered phospholipase A2: insight into the role of disulfide bonding patterns. Biochemistry. 2005 Mar 8; 44(9):3369-79. PMID: 15736947.
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    30. Bahnson BJ. Structure, function and interfacial allosterism in phospholipase A2: insight from the anion-assisted dimer. Arch Biochem Biophys. 2005 Jan 1; 433(1):96-106. PMID: 15581569.
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    31. Bahnson BJ. An atomic-resolution mechanism of 3-hydroxy-3-methylglutaryl-CoA synthase. Proc Natl Acad Sci U S A. 2004 Nov 23; 101(47):16399-400. PMID: 15546978.
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    32. Yeung DT, Josse D, Nicholson JD, Khanal A, McAndrew CW, Bahnson BJ, Lenz DE, Cerasoli DM. Structure/function analyses of human serum paraoxonase (HuPON1) mutants designed from a DFPase-like homology model. Biochim Biophys Acta. 2004 Oct 1; 1702(1):67-77. PMID: 15450851.
      View in: PubMed
    33. Ceccarelli C, Liang ZX, Strickler M, Prehna G, Goldstein BM, Klinman JP, Bahnson BJ. Crystal structure and amide H/D exchange of binary complexes of alcohol dehydrogenase from Bacillus stearothermophilus: insight into thermostability and cofactor binding. Biochemistry. 2004 May 11; 43(18):5266-77. PMID: 15122892.
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    34. Smart BP, Pan YH, Weeks AK, Bollinger JG, Bahnson BJ, Gelb MH. Inhibition of the complete set of mammalian secreted phospholipases A(2) by indole analogues: a structure-guided study. Bioorg Med Chem. 2004 Apr 1; 12(7):1737-49. PMID: 15028265.
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    35. Tessier PM, Johnson HR, Pazhianur R, Berger BW, Prentice JL, Bahnson BJ, Sandler SI, Lenhoff AM. Predictive crystallization of ribonuclease A via rapid screening of osmotic second virial coefficients. Proteins. 2003 Feb 1; 50(2):303-11. PMID: 12486724.
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    36. Pan YH, Yu BZ, Berg OG, Jain MK, Bahnson BJ. Crystal structure of phospholipase A2 complex with the hydrolysis products of platelet activating factor: equilibrium binding of fatty acid and lysophospholipid-ether at the active site may be mutually exclusive. Biochemistry. 2002 Dec 17; 41(50):14790-800. PMID: 12475227.
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    37. Ceccarelli C, Grodsky NB, Ariyaratne N, Colman RF, Bahnson BJ. Crystal structure of porcine mitochondrial NADP+-dependent isocitrate dehydrogenase complexed with Mn2+ and isocitrate. Insights into the enzyme mechanism. J Biol Chem. 2002 Nov 8; 277(45):43454-62. PMID: 12207025.
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    38. Pan YH, Yu BZ, Singer AG, Ghomashchi F, Lambeau G, Gelb MH, Jain MK, Bahnson BJ. Crystal structure of human group X secreted phospholipase A2. Electrostatically neutral interfacial surface targets zwitterionic membranes. J Biol Chem. 2002 Aug 9; 277(32):29086-93. PMID: 12161451.
      View in: PubMed
    39. Bahnson BJ, Anderson VE, Petsko GA. Structural mechanism of enoyl-CoA hydratase: three atoms from a single water are added in either an E1cb stepwise or concerted fashion. Biochemistry. 2002 Feb 26; 41(8):2621-9. PMID: 11851409.
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    40. D'Ordine RL, Pawlak J, Bahnson BJ, Anderson VE. Polarization of cinnamoyl-CoA substrates bound to enoyl-CoA hydratase: correlation of (13)C NMR with quantum mechanical calculations and calculation of electronic strain energy. Biochemistry. 2002 Feb 26; 41(8):2630-40. PMID: 11851410.
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    41. Epstein TM, Yu BZ, Pan YH, Tutton SP, Maliwal BP, Jain MK, Bahnson BJ. The basis for k(cat) impairment in prophospholipase A(2) from the anion-assisted dimer structure. Biochemistry. 2001 Sep 25; 40(38):11411-22. PMID: 11560489.
      View in: PubMed
    42. Pan YH, Epstein TM, Jain MK, Bahnson BJ. Five coplanar anion binding sites on one face of phospholipase A2: relationship to interface binding. Biochemistry. 2001 Jan 23; 40(3):609-17. PMID: 11170377.
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    43. Jeffery CJ, Bahnson BJ, Chien W, Ringe D, Petsko GA. Crystal structure of rabbit phosphoglucose isomerase, a glycolytic enzyme that moonlights as neuroleukin, autocrine motility factor, and differentiation mediator. Biochemistry. 2000 Feb 8; 39(5):955-64. PMID: 10653639.
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    44. Colby TD, Bahnson BJ, Chin JK, Klinman JP, Goldstein BM. Active site modifications in a double mutant of liver alcohol dehydrogenase: structural studies of two enzyme-ligand complexes. Biochemistry. 1998 Jun 30; 37(26):9295-304. PMID: 9649310.
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    45. Bahnson BJ, Colby TD, Chin JK, Goldstein BM, Klinman JP. A link between protein structure and enzyme catalyzed hydrogen tunneling. Proc Natl Acad Sci U S A. 1997 Nov 25; 94(24):12797-802. PMID: 9371755.
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    46. Bahnson BJ, Klinman JP. Hydrogen tunneling in enzyme catalysis. Methods Enzymol. 1995; 249:373-97. PMID: 7791619.
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    47. D'Ordine RL, Bahnson BJ, Tonge PJ, Anderson VE. Enoyl-coenzyme A hydratase-catalyzed exchange of the alpha-protons of coenzyme A thiol esters: a model for an enolized intermediate in the enzyme-catalyzed elimination? Biochemistry. 1994 Dec 13; 33(49):14733-42. PMID: 7993901.
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    48. Bahnson BJ, Park DH, Kim K, Plapp BV, Klinman JP. Unmasking of hydrogen tunneling in the horse liver alcohol dehydrogenase reaction by site-directed mutagenesis. Biochemistry. 1993 Jun 1; 32(21):5503-7. PMID: 8504071.
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    49. Bahnson BJ, Anderson VE. Crotonase-catalyzed beta-elimination is concerted: a double isotope effect study. Biochemistry. 1991 Jun 18; 30(24):5894-906. PMID: 2043630.
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    50. Anderson VE, Bahnson BJ, Wlassics ID, Walsh CT. The reaction of acetyldithio-CoA, a readily enolized analog of acetyl-CoA with thiolase from Zoogloea ramigera. J Biol Chem. 1990 Apr 15; 265(11):6255-61. PMID: 2180945.
      View in: PubMed
    51. Bahnson BJ, Anderson VE. Isotope effects on the crotonase reaction. Biochemistry. 1989 May 16; 28(10):4173-81. PMID: 2765479.
      View in: PubMed
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