Thomas Jefferson University

Constantine Daskalakis

TitleProfessor
InstitutionThomas Jefferson University
DepartmentPharmacology and Exp Therapeut
Address130 S. 9th Street
Philadelphia PA 19107
Phone215-955-5695
Email
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    Collapse Biography 
    Collapse education and training
    Harvard UniversityScD1998Biostatistics & Epidemiology

    Collapse Overview 
    Collapse overview
    I have formal training in both Biostatistics and Epidemiology, and my particular expertise is in categorical data (including longitudinal analyses), missing data, epidemiologic methods, and clinical trials. Over the past twenty years, I have helped design and implement numerous observational studies and randomized trials, with particular focus on informed decision-making, behavioral interventions, and cancer screening (colorectal, lung, and prostate).

    I have also been engaged in a wide range of educational activities:
    - development and teaching of formal courses (graduate level);
    - training of undergraduate and graduate students in (bio)statistics, public health, and other disciplines, including serving on 25+ Master's theses committees and serving as Director of Jefferson's Biostatistics Summer Internship (2015-present);
    - training of medical students, including serving as Director of Jefferson's summer research program (2013-2017) and Director of JeffMD curriculum's Scholarly Inquiry Program (2016-2020); and
    - mentoring of fellows and junior faculty.

    Professional activities:
    - Secretary/treasurer (2010-11) and Chair (2014), Section on Teaching of Statistics in Health Sciences, American Statistical Association.
    - Associate editor (2001-2012), American Journal of Epidemiology.

    Secretary/treasurer (2010-11) and Chair (2014), Section on Teaching of Statistics in Health Sciences, American Statistical Association.
    Associate editor (2001-present), American Journal of Epidemiology.



    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Myers R, Hallman MH, Davis K, DiCarlo M, Daskalakis C, Shimada A, Chambers C. Primary care provider perspectives on a planned multi-cancer early detection test clinical trial. Contemp Clin Trials Commun. 2023 Aug; 34:101183. PMID: 37456505.
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    2. Daskalakis C, Shimada A, Myers RE, Eastburn K, DiCarlo MA, Shusted CS, Barta JA. Decision Preferences in Shared Decision-Making for Lung Cancer Screening Among White and African American Individuals. Ann Am Thorac Soc. 2023 Feb 24. PMID: 36827233.
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    3. DiCarlo M, Myers P, Daskalakis C, Shimada A, Hegarty S, Zeigler-Johnson C, Juon HS, Barta J, Myers RE. Outreach to primary care patients in lung cancer screening: A randomized controlled trial. Prev Med. 2022 Jun; 159:107069. PMID: 35469777.
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    4. Coppock D, Violet PC, Vasquez G, Belden K, Foster M, Mullin B, Magee D, Mikell I, Shah L, Powers V, Curcio B, Daskalakis C, Monti D, Levine M. Pharmacologic Ascorbic Acid as Early Therapy for Hospitalized Patients with COVID-19: A Randomized Clinical Trial. Life (Basel). 2022 Mar 19; 12(3). PMID: 35330204.
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    5. Sherban A, Waseh S, Hugo A, Bui M, Daskalakis C, Jones E. Skin cancer biopsy and detection rates with total body skin examination: A cross-sectional retrospective analysis. J Am Acad Dermatol. 2021 Mar 23. PMID: 33771595.
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    6. Daskalakis C, DiCarlo M, Hegarty S, Gudur A, Vernon SW, Myers RE. Predictors of overall and test-specific colorectal Cancer screening adherence. Prev Med. 2020 Feb 08; 133:106022. PMID: 32045616.
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    7. Song A, Andrews DW, Werner-Wasik M, Kim L, Glass J, Bar-Ad V, Evans JJ, Farrell CJ, Judy KD, Daskalakis C, Zhan T, Shi W. Phase I trial of alisertib with concurrent fractionated stereotactic re-irradiation for recurrent high grade gliomas. Radiother Oncol. 2019 Mar; 132:135-141. PMID: 30825962.
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    8. Myers RE, Stello B, Daskalakis C, Sifri R, Gonzalez ET, DiCarlo M, Johnson MB, Hegarty SE, Shaak K, Rivera A, Gordils-Molina L, Petrich A, Careyva B, de-Ortiz R, Diaz L. Decision Support and Navigation to Increase Colorectal Cancer Screening among Hispanic Patients. Cancer Epidemiol Biomarkers Prev. 2018 Oct 17. PMID: 30333221.
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    9. Dastgheyb S, Fishlock K, Daskalakis C, Kessel J, Rosen P. Evaluating comfort measures for commonly performed painful procedures in pediatric patients. J Pain Res. 2018; 11:1383-1390. PMID: 30100753.
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    10. Gandhi K, Tofani C, Sokach C, Patel D, Kastenberg D, Daskalakis C. Patient Characteristics Associated With Quality of Colonoscopy Preparation: A Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol. 2018 Mar; 16(3):357-369.e10. PMID: 28826680.
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    11. Williams NL, Wuthrick EJ, Kim H, Palmer JD, Garg S, Eldredge-Hindy H, Daskalakis C, Feeney KJ, Mastrangelo MJ, Kim LJ, Sato T, Kendra KL, Olencki T, Liebner DA, Farrell CJ, Evans JJ, Judy KD, Andrews DW, Dicker AP, Werner-Wasik M, Shi W. Phase 1 Study of Ipilimumab Combined With Whole Brain Radiation Therapy or Radiosurgery for Melanoma Patients With Brain Metastases. Int J Radiat Oncol Biol Phys. 2017 Sep 01; 99(1):22-30. PMID: 28816150.
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    12. Erkes DA, Xu G, Daskalakis C, Zurbach KA, Wilski NA, Moghbeli T, Hill AB, Snyder CM. Intratumoral Infection with Murine Cytomegalovirus Synergizes with PD-L1 Blockade to Clear Melanoma Lesions and Induce Long-term Immunity. Mol Ther. 2016 Aug; 24(8):1444-55. PMID: 27434584.
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    13. Busack C, Daskalakis C, Rosen P. Physician and Parent Perspectives on Psychosocial and Emotional Data Entry in the Electronic Medical Record in a Pediatric Setting. J Patient Exp. 2016 Mar; 3(1):10-16. PMID: 28725826.
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    14. Cheng C, Daskalakis C. Association of ambulatory heart rate and atherosclerosis risk factors with blood pressure in young non-hypertensive adults. Open Heart. 2016; 3(1):e000332. PMID: 26925242.
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    15. Roy A, Smith C, Daskalakis C, Voorhees K, Moleski S, DiMarino AJ, Kastenberg D. Physicians Caring for Celiac Patients do not Routinely Recommend Screening of First-Degree Family Members. J Gastroenterol Hepatol Res. 2015 Dec; 4(12):1838-1843. PMID: 28164022.
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    16. Cheng C, Lee CW, Daskalakis C. A Reproducible Computerized Method for Quantitation of Capillary Density using Nailfold Capillaroscopy. J Vis Exp. 2015; (105). PMID: 26554744.
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    17. Cheng C, Daskalakis C. Association of Adipokines with Insulin Resistance, Microvascular Dysfunction, and Endothelial Dysfunction in Healthy Young Adults. Mediators Inflamm. 2015; 2015:594039. PMID: 26549941.
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    18. Goldhammer JE, Marhefka GD, Daskalakis C, Berguson MW, Bowen JE, Diehl JT, Sun J. The Effect of Aspirin on Bleeding and Transfusion in Contemporary Cardiac Surgery. PLoS One. 2015; 10(7):e0134670. PMID: 26230605.
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    19. Roy A, Smith C, Daskalakis C, Voorhees K, Moleski S, DiMarino AJ, Kastenberg D. . Physicians caring for celiac patients do not routinely recommend screening of first-degree family members. Journal of Gastroenterology and Hepatology Research. 2015; 12(4):1838-1843.
    20. Myers RE, Sifri R, Daskalakis C, DiCarlo M, Geethakumari PR, Cocroft J, Minnick C, Brisbon N, Vernon SW. Increasing colon cancer screening in primary care among african americans. J Natl Cancer Inst. 2014 Dec; 106(12). PMID: 25481829.
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    21. Daskalakis C, Vernon SW, Sifri R, DiCarlo M, Cocroft J, Sendecki JA, Myers RE. The effects of test preference, test access, and navigation on colorectal cancer screening. Cancer Epidemiol Biomarkers Prev. 2014 Aug; 23(8):1521-8. PMID: 24813819.
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    22. Matro R, Daskalakis C, Negoianu D, Katz L, Henry C, Share M, Kastenberg D. . Randomized clinical trial: polyethylene glycol 3350 with sports drink versus polyethylene glycol with electrolyte solution as purgatives for colonoscopy – the incidence of hyponatraemia. Alimentary Pharmacology and Therapeutics. 2014; 6(40):610-619.
    23. Draganova-Tacheva R, Bibbo M, Birbe R, Daskalakis C, Solomides C. The potential value of phosphohistone-h3 mitotic index determined by digital image analysis in the assessment of pancreatic endocrine tumors in fine-needle aspiration cytology specimens. Acta Cytol. 2013; 57(3):291-5. PMID: 23635399.
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    24. Wachsberger PR, Lawrence RY, Liu Y, Rice B, Daskalakis C, Dicker AP. Epidermal growth factor receptor mutation status and rad51 determine the response of glioblastoma to multimodality therapy with cetuximab, temozolomide, and radiation. Front Oncol. 2013; 3:13. PMID: 23383403.
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    25. Cheng C, Daskalakis C, Falkner B. Non-invasive Assessment of Microvascular and Endothelial Function. J Vis Exp. 2013; (71). PMID: 23407262.
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    26. Mago R, Kloos A, Daskalakis C, Shwarz M, Rovner BW. Identifying Potential Adverse Effects by Patients' Ratings: A Proof-of-Concept Study of a Novel Approach. J Clin Psychopharmacol. 2012 Dec; 32(6):828-31. PMID: 23131878.
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    27. Matro R, Tupchong K, Daskalakis C, Gordon V, Katz L, Kastenberg D. The effect on colon visualization during colonoscopy of the addition of simethicone to polyethylene glycol-electrolyte solution: a randomized single-blind study. Clin Transl Gastroenterol. 2012; 3:e26. PMID: 23238113.
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    28. Halegoua-De Marzio D, Kraft WK, Daskalakis C, Ying X, Hawke RL, Navarro VJ. Limited sampling estimates of epigallocatechin gallate exposures in cirrhotic and noncirrhotic patients with hepatitis C after single oral doses of green tea extract. Clin Ther. 2012 Dec; 34(12):2279-2285.e1. PMID: 23153661.
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    29. Myers RE, Bittner-Fagan H, Daskalakis C, Sifri R, Vernon SW, Cocroft J, Dicarlo M, Katurakes N, Andrel J. A randomized controlled trial of a tailored navigation and a standard intervention in colorectal cancer screening. Cancer Epidemiol Biomarkers Prev. 2013 Jan; 22(1):109-17. PMID: 23118143.
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    30. Toth-Capelli KM, Brawer R, Plumb J, Daskalakis C. Stage of change and other predictors of participant retention in a behavioral weight management program in primary care. Health Promot Pract. 2013 May; 14(3):441-50. PMID: 23091300.
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    31. Godbole AM, Purushottamachar P, Martin MS, Daskalakis C, Njar VC. Autophagy inhibition synergistically enhances anticancer efficacy of RAMBA, VN/12-1 in SKBR-3 cells, and tumor xenografts. Mol Cancer Ther. 2012 Apr; 11(4):898-908. PMID: 22334589.
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    32. Fagan HB, Myers RE, Daskalakis C, Sifri R, Mainous AG, Wender R. Race/Ethnicity, gender, weight status, and colorectal cancer screening. J Obes. 2011; 2011:314619. PMID: 22187635.
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    33. DeLoach SS, Daskalakis C, Gidding S, Falkner B. Central blood pressures are associated with left ventricular mass index among African-American adolescents. Am J Hypertens. 2012 Jan; 25(1):41-5. PMID: 21976275.
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    34. Leader A, Daskalakis C, Braddock CH, Kunkel EJ, Cocroft JR, Bereknyei S, Riggio JM, Capkin M, Myers RE. Measuring informed decision making about prostate cancer screening in primary care. Med Decis Making. 2012 Mar-Apr; 32(2):327-36. PMID: 21685377.
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    35. Rappaport EB, Daskalakis C, Andrel J. Obesity and other predictors of absenteeism in Philadelphia school children. J Sch Health. 2011 Jun; 81(6):341-4. PMID: 21592129.
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    36. Cheng C, Daskalakis C, Falkner B. Alterations in capillary morphology are found in mild blood pressure elevation. J Hypertens. 2010 Nov; 28(11):2258-66. PMID: 20724940.
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    37. Fenkel JM, Coron RN, Daskalakis C, Vega M, Rossi S, Herrine SK, Navarro VJ. Over-the-counter analgesics in cirrhotic patients: a case-control study examining the risk of hospitalization for liver-associated events. Scand J Gastroenterol. 2010 Sep; 45(9):1101-9. PMID: 20230184.
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    38. DeLoach S, Huan Y, Daskalakis C, Falkner B. Endothelin-1 response to glucose and insulin among African Americans. J Am Soc Hypertens. 2010 Sep-Oct; 4(5):227-35. PMID: 20728421.
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    39. Doria C, Bodzin AS, Vaccino S, Daskalakis C, Krawitz S, Ramirez CB. A retrospective analysis of the use of caspofungin in recipients of liver transplant with a modified high index of suspicion for fungal infection. A critical review of mortality, acute cellular rejection, infections, and changes in the liver function tests while on caspofungin. Clin Transplant. 2011 Jul-Aug; 25(4):569-75. PMID: 20662881.
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    40. Myers RE, Daskalakis C, Kunkel EJ, Cocroft JR, Riggio JM, Capkin M, Braddock CH. Mediated decision support in prostate cancer screening: a randomized controlled trial of decision counseling. Patient Educ Couns. 2011 May; 83(2):240-6. PMID: 20619576.
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    41. Matro R, Shnitser A, Spodik M, Daskalakis C, Katz L, Murtha A, Kastenberg D. Efficacy of morning-only compared with split-dose polyethylene glycol electrolyte solution for afternoon colonoscopy: a randomized controlled single-blind study. Am J Gastroenterol. 2010 Sep; 105(9):1954-61. PMID: 20407434.
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    42. Huan Y, DeLoach S, Daskalakis C, Dunn SR, Sharma K, Falkner B. Regulation of transforming growth factor-beta1 by insulin in prediabetic African Americans. Kidney Int. 2010 Aug; 78(3):318-24. PMID: 20393450.
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    43. Schneider JS, Sendek S, Daskalakis C, Cambi F. GM1 ganglioside in Parkinson's disease: Results of a five year open study. J Neurol Sci. 2010 May 15; 292(1-2):45-51. PMID: 20206941.
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    44. Cheng C, Daskalakis C, Falkner B. Association of capillary density and function measures with blood pressure, fasting plasma glucose, and insulin sensitivity. J Clin Hypertens (Greenwich). 2010 Feb 1; 12(2):125-35. PMID: 20167040.
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    45. Watford WT, Wang CC, Tsatsanis C, Mielke LA, Eliopoulos AG, Daskalakis C, Charles N, Odom S, Rivera J, O'Shea J, Tsichlis PN. Ablation of tumor progression locus 2 promotes a type 2 Th cell response in Ovalbumin-immunized mice. J Immunol. 2010 Jan 1; 184(1):105-13. PMID: 19955521.
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    46. Kim DH, Daskalakis C, Silvestry SC, Sheth MP, Lee AN, Adams S, Hohmann S, Medvedev S, Whellan DJ. Aspirin and clopidogrel use in the early postoperative period following on-pump and off-pump coronary artery bypass grafting. J Thorac Cardiovasc Surg. 2009 Dec; 138(6):1377-84. PMID: 19931667.
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    47. Wachsberger P, Burd R, Ryan A, Daskalakis C, Dicker AP. Combination of vandetanib, radiotherapy, and irinotecan in the LoVo human colorectal cancer xenograft model. Int J Radiat Oncol Biol Phys. 2009 Nov 1; 75(3):854-61. PMID: 19801101.
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    48. Salerno D, Marik PE, Daskalakis C, Kolm P, Leone F. The role of head computer tomographic scans on the management of MICU patients with neurological dysfunction. J Intensive Care Med. 2009 Nov-Dec; 24(6):372-5. PMID: 19875389.
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    49. Kim DH, Daskalakis C, Whellan DJ, Whitman IR, Hohmann S, Medvedev S, Kraft WK. Safety of selective serotonin reuptake inhibitor in adults undergoing coronary artery bypass grafting. Am J Cardiol. 2009 May 15; 103(10):1391-5. PMID: 19427434.
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    50. Ciocca V, Daskalakis C, Ciocca RM, Ruiz-Orrico A, Palazzo JP. The significance of GATA3 expression in breast cancer: a 10-year follow-up study. Hum Pathol. 2009 Apr; 40(4):489-95. PMID: 19084267.
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    51. Kim DH, Daskalakis C, Lee AN, Adams S, Hohmann S, Silvestry SC, Medvedev S, Whellan DJ. Racial disparity in the relationship between hospital volume and mortality among patients undergoing coronary artery bypass grafting. Ann Surg. 2008 Nov; 248(5):886-92. PMID: 18948819.
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    52. Brotz C, Nandi N, Conn M, Daskalakis C, DiMarino M, Infantolino A, Katz LC, Schroeder T, Kastenberg D. A validation study of 3 grading systems to evaluate small-bowel cleansing for wireless capsule endoscopy: a quantitative index, a qualitative evaluation, and an overall adequacy assessment. Gastrointest Endosc. 2009 Feb; 69(2):262-70, 270.e1. PMID: 18851851.
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    53. Kim DH, Daskalakis C, Plumb JD, Adams S, Brawer R, Orr N, Hawthorne K, Toto EC, Whellan DJ. Modifiable cardiovascular risk factors among individuals in low socioeconomic communities and homeless shelters. Fam Community Health. 2008 Oct-Dec; 31(4):269-80. PMID: 18794634.
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    54. Cheng C, Daskalakis C, Falkner B. Capillary rarefaction in treated and untreated hypertensive subjects. Ther Adv Cardiovasc Dis. 2008 Apr; 2(2):79-88. PMID: 19124411.
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    55. Jakab SS, Navarro VJ, Colombe BW, Daskalakis C, Herrine SK, Rossi S. Human leukocyte antigen and adult living-donor liver transplantation outcomes: an analysis of the organ procurement and transplantation network database. Liver Transpl. 2007 Oct; 13(10):1405-13. PMID: 17902126.
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    56. Shenassa ED, Daskalakis C, Liebhaber A, Braubach M, Brown M. Dampness and mold in the home and depression: an examination of mold-related illness and perceived control of one's home as possible depression pathways. Am J Public Health. 2007 Oct; 97(10):1893-9. PMID: 17761567.
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    57. Berghella V, Roman A, Daskalakis C, Ness A, Baxter JK. Gestational age at cervical length measurement and incidence of preterm birth. Obstet Gynecol. 2007 Aug; 110(2 Pt 1):311-7. PMID: 17666605.
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    58. Showalter TN, Andrel J, Andrews DW, Curran WJ, Daskalakis C, Werner-Wasik M. Multifocal glioblastoma multiforme: prognostic factors and patterns of progression. Int J Radiat Oncol Biol Phys. 2007 Nov 1; 69(3):820-4. PMID: 17499453.
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    59. Ghanim AJ, Daskalakis C, Eschelman DJ, Kraft WK. A five-year, retrospective, comparison review of survival in neurosurgical patients diagnosed with venous thromboembolism and treated with either inferior vena cava filters or anticoagulants. J Thromb Thrombolysis. 2007 Dec; 24(3):247-54. PMID: 17385008.
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    60. Wachsberger PR, Burd R, Cardi C, Thakur M, Daskalakis C, Holash J, Yancopoulos GD, Dicker AP. VEGF trap in combination with radiotherapy improves tumor control in u87 glioblastoma. Int J Radiat Oncol Biol Phys. 2007 Apr 1; 67(5):1526-37. PMID: 17234361.
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    61. Myers RE, Berry A, Bradley P, Cocroft J, Daskalakis C, Delmoor E, Fleisher L, Kasper-Keintz M, Witt D. Increasing access to clinical and educational studies. Cancer. 2006 Oct 15; 107(8 Suppl):1962-70. PMID: 16986164.
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    62. Kairys JC, Daskalakis C, Weigel RJ. Surgeon-performed ultrasound for preoperative localization of abnormal parathyroid glands in patients with primary hyperparathyroidism. World J Surg. 2006 Sep; 30(9):1658-63; discussion 1664. PMID: 16855801.
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    63. Shenassa ED, Daskalakis C, Buka SL. Utility of indices of gun availability in the community. J Epidemiol Community Health. 2006 Jan; 60(1):44-9. PMID: 16401610.
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    64. Zisselman MH, Smith RV, Smith SA, Daskalakis C, Sanchez F. Racial and socioeconomic differences in psychiatric symptoms in nursing home residents: a minimum data set-based pilot study. J Am Med Dir Assoc. 2006 Jan; 7(1):17-22. PMID: 16413430.
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    65. Myers RE, Daskalakis C, Cocroft J, Kunkel EJ, Delmoor E, Liberatore M, Nydick RL, Brown ER, Gay RN, Powell T, Powell RL. Preparing African-American men in community primary care practices to decide whether or not to have prostate cancer screening. J Natl Med Assoc. 2005 Aug; 97(8):1143-54. PMID: 16173330.
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    66. Parikh P, Palazzo JP, Rose LJ, Daskalakis C, Weigel RJ. GATA-3 expression as a predictor of hormone response in breast cancer. J Am Coll Surg. 2005 May; 200(5):705-10. PMID: 15848360.
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    67. Wachsberger PR, Burd R, Marero N, Daskalakis C, Ryan A, McCue P, Dicker AP. Effect of the tumor vascular-damaging agent, ZD6126, on the radioresponse of U87 glioblastoma. Clin Cancer Res. 2005 Jan 15; 11(2 Pt 1):835-42. PMID: 15701874.
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    68. Shenassa E, Daskalakis C. Smoking prevention: implications of study design, research setting, and goals. Nicotine Tob Res. 2004 Apr; 6(2):321-5. PMID: 15203806.
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    69. Kunkel EJ, Meyer B, Daskalakis C, Cocroft J, Jennings-Dozier K, Myers RE. Behaviors used by men to protect themselves against prostate cancer. Cancer Epidemiol Biomarkers Prev. 2004 Jan; 13(1):78-86. PMID: 14744737.
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    70. Lanza-Jacoby S, Miller S, Flynn J, Gallatig K, Daskalakis C, Masferrer JL, Zweifel BS, Sembhi H, Russo IH. The cyclooxygenase-2 inhibitor, celecoxib, prevents the development of mammary tumors in Her-2/neu mice. Cancer Epidemiol Biomarkers Prev. 2003 Dec; 12(12):1486-91. PMID: 14693742.
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    71. Coss RA, Storck CW, Daskalakis C, Berd D, Wahl ML. Intracellular acidification abrogates the heat shock response and compromises survival of human melanoma cells. Mol Cancer Ther. 2003 Apr; 2(4):383-8. PMID: 12700282.
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    72. Burd R, Lavorgna SN, Daskalakis C, Wachsberger PR, Wahl ML, Biaglow JE, Stevens CW, Leeper DB. Tumor oxygenation and acidification are increased in melanoma xenografts after exposure to hyperglycemia and meta-iodo-benzylguanidine. Radiat Res. 2003 Mar; 159(3):328-35. PMID: 12600235.
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    73. Daskalakis C, Laird NM, Murphy JM. Regression analysis of multiple-source longitudinal outcomes: a "Stirling County" depression study. Am J Epidemiol. 2002 Jan 1; 155(1):88-94. PMID: 11772789.
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