Thomas Jefferson University

Douglas Hooper

TitleFaculty
InstitutionThomas Jefferson University
DepartmentCancer Biology - Thomas Jefferson University
Address1020 Locust Street
Philadelphia PA 19107
Phone2155031774
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    Collapse Research 
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    R21AT001301     (HOOPER, DOUGLAS CRAIG)Jul 1, 2003 - Sep 30, 2005
    NIH
    Inosine in the over-the-counter treatment of MS
    Role: Principal Investigator
    R21AT003432     (HOOPER, DOUGLAS CRAIG)Sep 30, 2006 - Aug 31, 2009
    NIH
    Uric Acid: An Alternative Approach to the Prevention of Spinal Cord Injury?
    Role: Principal Investigator
    R01AI060005     (HOOPER, DOUGLAS CRAIG)Apr 1, 2007 - Mar 31, 2011
    NIH
    Passive Immunization for Neurotropic Virus Infection
    Role: Principal Investigator
    R21AI077033     (HOOPER, DOUGLAS CRAIG)Sep 1, 2007 - Aug 31, 2009
    NIH
    Maintenance of Blood-Brain Barrier Integrity as a Neurotropic Virus Immunizaiton
    Role: Principal Investigator
    U01AI083046     (HOOPER, DOUGLAS CRAIG)May 1, 2009 - Apr 30, 2015
    NIH
    Host-pathogen competition in IFN mediated antiviral defense
    Role: Principal Investigator
    R01AI093369     (HOOPER, DOUGLAS CRAIG)Jun 1, 2011 - Dec 31, 2016
    NIH
    Virus Clearance from the Central Nervous System
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Castagnino PA, Haas DA, Musante L, Tancler NA, Tran BV, Kean R, Steck AR, Martinez LA, Mostaghel EA, Hooper DC, Kim FJ. Sigma1 inhibitor suppression of adaptive immune resistance mechanisms mediated by cancer cell derived extracellular vesicles. Cancer Biol Ther. 2025 Dec; 26(1):2455722. PMID: 39863992.
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    2. Naranjo NM, Kennedy A, Testa A, Verrillo CE, Altieri AD, Kean R, Hooper DC, Yu J, Zhao J, Abinader O, Pickles MW, Hawkins A, Kelly WK, Mitra R, Languino LR. Neuroendocrine gene subsets are uniquely dysregulated in prostate adenocarcinoma. Cancer Biol Ther. 2024 Dec 31; 25(1):2364433. PMID: 38926911.
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    3. Testa A, Quaglia F, Naranjo NM, Verrillo CE, Shields CD, Lin S, Pickles MW, Hamza DF, Von Schalscha T, Cheresh DA, Leiby B, Liu Q, Ding J, Kelly WK, Hooper DC, Corey E, Plow EF, Altieri DC, Languino LR. Targeting the aV?3/NgR2 pathway in neuroendocrine prostate cancer. Matrix Biol. 2023 12; 124:49-62. PMID: 37956856.
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    4. Irabor OC, Nelson N, Shah Y, Niazi MK, Poiset S, Storozynsky E, Singla DK, Hooper DC, Lu B. Overcoming the cardiac toxicities of cancer therapy immune checkpoint inhibitors. Front Oncol. 2022; 12:940127. PMID: 36185227.
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    5. Prosniak M, Harshyne LA, Gorky J, Curtis MT, Kenyon LC, Schwaber JS, Lebrun A, Kean RB, Andrews DW, Hooper DC. Systemic Immune Bias Delineates Malignant Astrocytoma Survival Cohorts. J Immunol. 2021 04 01; 206(7):1483-1492. PMID: 33685995.
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    6. Martos-Rus C, Katz-Greenberg G, Lin Z, Serrano E, Whitaker-Menezes D, Domingo-Vidal M, Roche M, Ramaswamy K, Hooper DC, Falkner B, Martinez Cantarin MP. Macrophage and adipocyte interaction as a source of inflammation in kidney disease. Sci Rep. 2021 02 03; 11(1):2974. PMID: 33536542.
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    7. Andrews DW, Judy KD, Scott CB, Garcia S, Harshyne LA, Kenyon L, Talekar K, Flanders A, Atsina KB, Kim L, Martinez N, Shi W, Werner-Wasik M, Liu H, Prosniak M, Curtis M, Kean R, Ye DY, Bongiorno E, Sauma S, Exley MA, Pigott K, Hooper DC. Phase Ib Clinical Trial of IGV-001 for Patients with Newly Diagnosed Glioblastoma. Clin Cancer Res. 2021 04 01; 27(7):1912-1922. PMID: 33500356.
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    8. Lebrun A, Kean RB, Hooper DC. Brain tissue-resident immune memory cells are required for long-term protection against CNS infection with rabies virus. Future Virol. 2020 Nov; 15(11):755-761. PMID: 33343683.
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    9. Tripathi SK, Kean R, Bongiorno E, Hooper DC, Jin YY, Wickstrom E, McCue PA, Thakur ML. Targeting VPAC1 Receptors for Imaging Glioblastoma. Mol Imaging Biol. 2020 04; 22(2):293-302. PMID: 31292914.
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    10. Lin J, Song AJ, Hoffman-Censits J, Leiby BE, Tuluc M, Shaw C, Harshyne L, Kean R, Bar-Ad V, Den RB, Hurwitz MD, Louie J, Philipose S, Deshmukh SP, Johnson JM, Dicker AP, Hooper DC, Kelly WK, Lu B. A Pilot Study of Radiation Therapy in Combination With Pembrolizumab in Patients With Metastatic Renal Cell Cancer. Am J Clin Oncol. 2020 02; 43(2):82-86. PMID: 31693508.
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    11. Schmidt RF, Theofanis TN, Lang MJ, Stricsek GP, Lin R, Lebrun A, Hooper DC, Rosenwasser RH, Sharan AD, Iacovitti L. Sphenopalatine ganglion stimulation is a reversible and frequency-dependent modulator of the blood-brain barrier. Brain Res. 2019 09 01; 1718:231-241. PMID: 31034813.
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    12. Languino LR, Hooper DC. Activated Extracellular Vesicles as New Therapeutic Targets? Trends Cell Biol. 2019 04; 29(4):276-278. PMID: 30826213.
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    13. Palmieri EM, Menga A, Mart?n-P?rez R, Quinto A, Riera-Domingo C, De Tullio G, Hooper DC, Lamers WH, Ghesqui?re B, McVicar DW, Guarini A, Mazzone M, Castegna A. Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis. Cell Rep. 2017 08 15; 20(7):1654-1666. PMID: 28813676.
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    14. Pestell TG, Jiao X, Kumar M, Peck AR, Prisco M, Deng S, Li Z, Ertel A, Casimiro MC, Ju X, Di Rocco A, Di Sante G, Katiyar S, Shupp A, Lisanti MP, Jain P, Wu K, Rui H, Hooper DC, Yu Z, Goldman AR, Speicher DW, Laury-Kleintop L, Pestell RG. Stromal cyclin D1 promotes heterotypic immune signaling and breast cancer growth. Oncotarget. 2017 Oct 10; 8(47):81754-81775. PMID: 29137220.
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    15. Lebrun A, Garcia S, Li J, Kean RB, Hooper DC. Protection Against CNS-Targeted Rabies Virus Infection is Dependent upon Type-1 Immune Mechanisms Induced by Live-Attenuated Rabies Vaccines. Trop Med Infect Dis. 2017 Jul 04; 2(3). PMID: 30270881.
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    16. Bongiorno EK, Garcia SA, Sauma S, Hooper DC. Type 1 Immune Mechanisms Driven by the Response to Infection with Attenuated Rabies Virus Result in Changes in the Immune Bias of the Tumor Microenvironment and Necrosis of Mouse GL261 Brain Tumors. J Immunol. 2017 06 01; 198(11):4513-4523. PMID: 28461570.
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    17. Fortuna D, C?rdenas AM, Graf EH, Harshyne LA, Hooper DC, Prosniak M, Shields J, Curtis MT. Human parechovirus and enterovirus initiate distinct CNS innate immune responses: Pathogenic and diagnostic implications. J Clin Virol. 2017 01; 86:39-45. PMID: 27914285.
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    18. Palmieri EM, Menga A, Lebrun A, Hooper DC, Butterfield DA, Mazzone M, Castegna A. Blockade of Glutamine Synthetase Enhances Inflammatory Response in Microglial Cells. Antioxid Redox Signal. 2017 03 10; 26(8):351-363. PMID: 27758118.
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    19. Alexander GS, Palmer JD, Tuluc M, Lin J, Dicker AP, Bar-Ad V, Harshyne LA, Louie J, Shaw CM, Hooper DC, Lu B. Immune biomarkers of treatment failure for a patient on a phase I clinical trial of pembrolizumab plus radiotherapy. J Hematol Oncol. 2016 Sep 23; 9(1):96. PMID: 27663515.
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    20. Joneja U, Hooper DC, Evans JJ, Curtis MT. Postpartum Granulomatous Hypophysitis: A Case Study, Review of the Literature, and Discussion of Pathogenesis. Case Rep Pathol. 2016; 2016:7510323. PMID: 27642532.
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    21. Lebrun A, Portocarrero C, Kean RB, Barkhouse DA, Faber M, Hooper DC. T-bet Is Required for the Rapid Clearance of Attenuated Rabies Virus from Central Nervous System Tissue. J Immunol. 2015 Nov 01; 195(9):4358-68. PMID: 26408670.
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    22. Gnanadurai CW, Yang Y, Huang Y, Li Z, Leyson CM, Cooper TL, Platt SR, Harvey SB, Hooper DC, Faber M, Fu ZF. Differential Host Immune Responses after Infection with Wild-Type or Lab-Attenuated Rabies Viruses in Dogs. PLoS Negl Trop Dis. 2015; 9(8):e0004023. PMID: 26292099.
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    23. Melamed E, Levy M, Waters PJ, Sato DK, Bennett JL, John GR, Hooper DC, Saiz A, Bar-Or A, Kim HJ, Pandit L, Leite MI, Asgari N, Kissani N, Hintzen R, Marignier R, Jarius S, Marcelletti J, Smith TJ, Yeaman MR, Han MH, Aktas O, Apiwattanakul M, Banwell B, Bichuetti D, Broadley S, Cabre P, Chitnis T, De Seze J, Fujihara K, Greenberg B, Hellwig K, Iorio R, Jarius S, Klawiter E, Kleiter I, Lana-Peixoto M, O'Connor K, Palace J, Paul F, Prayoonwiwat N, Ruprecht K, Stuve O, Tedder T, Tenembaum S, Garrahan JP, Aires B, van Herle K, van Pelt D, Villoslada P, Waubant E, Weinshenker B, Wingerchuk D, W?rfel J, Zamvil S. Update on biomarkers in neuromyelitis optica. Neurol Neuroimmunol Neuroinflamm. 2015 Aug; 2(4):e134. PMID: 26236760.
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    24. Harshyne LA, Nasca BJ, Kenyon LC, Andrews DW, Hooper DC. Serum exosomes and cytokines promote a T-helper cell type 2 environment in the peripheral blood of glioblastoma patients. Neuro Oncol. 2016 Feb; 18(2):206-15. PMID: 26180083.
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    25. Palmieri EM, Spera I, Menga A, Infantino V, Porcelli V, Iacobazzi V, Pierri CL, Hooper DC, Palmieri F, Castegna A. Acetylation of human mitochondrial citrate carrier modulates mitochondrial citrate/malate exchange activity to sustain NADPH production during macrophage activation. Biochim Biophys Acta. 2015 Aug; 1847(8):729-38. PMID: 25917893.
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    26. Morin-Brureau M, Hooper KM, Prosniak M, Sauma S, Harshyne LA, Andrews DW, Hooper DC. Enhancement of glioma-specific immunity in mice by "NOBEL", an insulin-like growth factor 1 receptor antisense oligodeoxynucleotide. Cancer Immunol Immunother. 2015 Apr; 64(4):447-57. PMID: 25579379.
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    27. Amenta PS, Jallo JI, Tuma RF, Hooper DC, Elliott MB. Cannabinoid receptor type-2 stimulation, blockade, and deletion alter the vascular inflammatory responses to traumatic brain injury. J Neuroinflammation. 2014 Nov 22; 11:191. PMID: 25416141.
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    28. Barkhouse DA, Faber M, Hooper DC. Pre- and post-exposure safety and efficacy of attenuated rabies virus vaccines are enhanced by their expression of IFN?. Virology. 2015 Jan 01; 474:174-80. PMID: 25463615.
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    29. Harshyne LA, Hooper KM, Andrews EG, Nasca BJ, Kenyon LC, Andrews DW, Hooper DC. Glioblastoma exosomes and IGF-1R/AS-ODN are immunogenic stimuli in a translational research immunotherapy paradigm. Cancer Immunol Immunother. 2015 Mar; 64(3):299-309. PMID: 25391690.
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    30. Barkhouse DA, Garcia SA, Bongiorno EK, Lebrun A, Faber M, Hooper DC. Expression of interferon gamma by a recombinant rabies virus strongly attenuates the pathogenicity of the virus via induction of type I interferon. J Virol. 2015 Jan; 89(1):312-22. PMID: 25320312.
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    31. Schutsky K, Portocarrero C, Hooper DC, Dietzschold B, Faber M. Limited brain metabolism changes differentiate between the progression and clearance of rabies virus. PLoS One. 2014; 9(4):e87180. PMID: 24763072.
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    32. Prosniak M, Harshyne LA, Andrews DW, Kenyon LC, Bedelbaeva K, Apanasovich TV, Heber-Katz E, Curtis MT, Cotzia P, Hooper DC. Glioma grade is associated with the accumulation and activity of cells bearing M2 monocyte markers. Clin Cancer Res. 2013 Jul 15; 19(14):3776-86. PMID: 23741072.
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    33. Schutsky K, Curtis D, Bongiorno EK, Barkhouse DA, Kean RB, Dietzschold B, Hooper DC, Faber M. Intramuscular inoculation of mice with the live-attenuated recombinant rabies virus TriGAS results in a transient infection of the draining lymph nodes and a robust, long-lasting protective immune response against rabies. J Virol. 2013 Feb; 87(3):1834-41. PMID: 23192867.
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    34. Freeman K, Brureau A, Vadigepalli R, Staehle MM, Brureau MM, Gonye GE, Hoek JB, Hooper DC, Schwaber JS. Temporal changes in innate immune signals in a rat model of alcohol withdrawal in emotional and cardiorespiratory homeostatic nuclei. J Neuroinflammation. 2012 May 24; 9:97. PMID: 22626265.
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    35. Li J, Ertel A, Portocarrero C, Barkhouse DA, Dietzschold B, Hooper DC, Faber M. Postexposure treatment with the live-attenuated rabies virus (RV) vaccine TriGAS triggers the clearance of wild-type RV from the Central Nervous System (CNS) through the rapid induction of genes relevant to adaptive immunity in CNS tissues. J Virol. 2012 Mar; 86(6):3200-10. PMID: 22238315.
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    36. Hooper DC, Roy A, Kean RB, Phares TW, Barkhouse DA. Therapeutic immune clearance of rabies virus from the CNS. Future Virol. 2011 Mar 01; 6(3):387-397. PMID: 21686076.
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    37. Li J, Faber M, Dietzschold B, Hooper DC. The role of toll-like receptors in the induction of immune responses during rabies virus infection. Adv Virus Res. 2011; 79:115-26. PMID: 21601045.
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    38. Hooper DC, Roy A, Barkhouse DA, Li J, Kean RB. Rabies virus clearance from the central nervous system. Adv Virus Res. 2011; 79:55-71. PMID: 21601042.
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    39. O'Connell AE, Kerepesi LA, Vandergrift GL, Herbert DR, VAN Winkle TJ, Hooper DC, Pearce EJ, Abraham D. IL-4(-/-) mice with lethal Mesocestoides corti infections--reduced Th2 cytokines and alternatively activated macrophages. Parasite Immunol. 2009 Dec; 31(12):741-9. PMID: 19891612.
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    40. Spitsin S, Markowitz CE, Zimmerman V, Koprowski H, Hooper DC. Modulation of serum uric acid levels by inosine in patients with multiple sclerosis does not affect blood pressure. J Hum Hypertens. 2010 May; 24(5):359-62. PMID: 19865105.
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    41. Hooper DC, Phares TW, Fabis MJ, Roy A. The production of antibody by invading B cells is required for the clearance of rabies virus from the central nervous system. PLoS Negl Trop Dis. 2009 Oct 06; 3(10):e535. PMID: 19806203.
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    42. Luzi P, Abraham RM, Rafi MA, Curtis M, Hooper DC, Wenger DA. Effects of treatments on inflammatory and apoptotic markers in the CNS of mice with globoid cell leukodystrophy. Brain Res. 2009 Dec 01; 1300:146-58. PMID: 19748497.
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    43. Faber M, Li J, Kean RB, Hooper DC, Alugupalli KR, Dietzschold B. Effective preexposure and postexposure prophylaxis of rabies with a highly attenuated recombinant rabies virus. Proc Natl Acad Sci U S A. 2009 Jul 07; 106(27):11300-5. PMID: 19581599.
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    44. Hooper DC. Plant vaccines: an immunological perspective. Curr Top Microbiol Immunol. 2009; 332:1-11. PMID: 19401818.
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    45. Roy A, Hooper DC. Immune evasion by rabies viruses through the maintenance of blood-brain barrier integrity. J Neurovirol. 2008 Oct; 14(5):401-11. PMID: 19016377.
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    46. Fabis MJ, Phares TW, Kean RB, Koprowski H, Hooper DC. Blood-brain barrier changes and cell invasion differ between therapeutic immune clearance of neurotrophic virus and CNS autoimmunity. Proc Natl Acad Sci U S A. 2008 Oct 07; 105(40):15511-6. PMID: 18829442.
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    47. Spitsin S, Portocarrero C, Phares TW, Kean RB, Brimer CM, Koprowski H, Hooper DC. Early blood-brain barrier permeability in cerebella of PLSJL mice immunized with myelin basic protein. J Neuroimmunol. 2008 May 30; 196(1-2):8-15. PMID: 18406473.
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    48. Phares TW, Fabis MJ, Brimer CM, Kean RB, Hooper DC. A peroxynitrite-dependent pathway is responsible for blood-brain barrier permeability changes during a central nervous system inflammatory response: TNF-alpha is neither necessary nor sufficient. J Immunol. 2007 Jun 01; 178(11):7334-43. PMID: 17513784.
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    49. Roy A, Hooper DC. Lethal silver-haired bat rabies virus infection can be prevented by opening the blood-brain barrier. J Virol. 2007 Aug; 81(15):7993-8. PMID: 17507463.
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    50. Fabis MJ, Scott GS, Kean RB, Koprowski H, Hooper DC. Loss of blood-brain barrier integrity in the spinal cord is common to experimental allergic encephalomyelitis in knockout mouse models. Proc Natl Acad Sci U S A. 2007 Mar 27; 104(13):5656-61. PMID: 17372191.
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    51. Roy A, Phares TW, Koprowski H, Hooper DC. Failure to open the blood-brain barrier and deliver immune effectors to central nervous system tissues leads to the lethal outcome of silver-haired bat rabies virus infection. J Virol. 2007 Feb; 81(3):1110-8. PMID: 17108029.
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    52. Phares TW, Kean RB, Mikheeva T, Hooper DC. Regional differences in blood-brain barrier permeability changes and inflammation in the apathogenic clearance of virus from the central nervous system. J Immunol. 2006 Jun 15; 176(12):7666-75. PMID: 16751414.
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    53. Scott GS, Cuzzocrea S, Genovese T, Koprowski H, Hooper DC. Uric acid protects against secondary damage after spinal cord injury. Proc Natl Acad Sci U S A. 2005 Mar 01; 102(9):3483-8. PMID: 15728348.
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    54. Hooper DC. The role of immune responses in the pathogenesis of rabies. J Neurovirol. 2005 Feb; 11(1):88-92. PMID: 15804966.
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    55. Scott GS, Kean RB, Fabis MJ, Mikheeva T, Brimer CM, Phares TW, Spitsin SV, Hooper DC. ICAM-1 upregulation in the spinal cords of PLSJL mice with experimental allergic encephalomyelitis is dependent upon TNF-alpha production triggered by the loss of blood-brain barrier integrity. J Neuroimmunol. 2004 Oct; 155(1-2):32-42. PMID: 15342194.
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    56. Scott GS, Kean RB, Mikheeva T, Fabis MJ, Mabley JG, Szab? C, Hooper DC. The therapeutic effects of PJ34 [N-(6-oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide.HCl], a selective inhibitor of poly(ADP-ribose) polymerase, in experimental allergic encephalomyelitis are associated with immunomodulation. J Pharmacol Exp Ther. 2004 Sep; 310(3):1053-61. PMID: 15159442.
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    57. Verch T, Hooper DC, Kiyatkin A, Steplewski Z, Koprowski H. Immunization with a plant-produced colorectal cancer antigen. Cancer Immunol Immunother. 2004 Feb; 53(2):92-9. PMID: 14566428.
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    58. Prosniak M, Faber M, Hanlon CA, Rupprecht CE, Hooper DC, Dietzschold B. Development of a cocktail of recombinant-expressed human rabies virus-neutralizing monoclonal antibodies for postexposure prophylaxis of rabies. J Infect Dis. 2003 Jul 01; 188(1):53-6. PMID: 12825170.
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    59. Prosniak M, Zborek A, Scott GS, Roy A, Phares TW, Koprowski H, Hooper DC. Differential expression of growth factors at the cellular level in virus-infected brain. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6765-70. PMID: 12736376.
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    60. Scott GS, Vir?g L, Szab? C, Hooper DC. Peroxynitrite-induced oligodendrocyte toxicity is not dependent on poly(ADP-ribose) polymerase activation. Glia. 2003 Jan 15; 41(2):105-16. PMID: 12509801.
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    61. Scott GS, Spitsin SV, Kean RB, Mikheeva T, Koprowski H, Hooper DC. Therapeutic intervention in experimental allergic encephalomyelitis by administration of uric acid precursors. Proc Natl Acad Sci U S A. 2002 Dec 10; 99(25):16303-8. PMID: 12451183.
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    62. Spitsin SV, Scott GS, Mikheeva T, Zborek A, Kean RB, Brimer CM, Koprowski H, Hooper DC. Comparison of uric acid and ascorbic acid in protection against EAE. Free Radic Biol Med. 2002 Nov 15; 33(10):1363-71. PMID: 12419468.
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    63. Yusibov V, Hooper DC, Spitsin SV, Fleysh N, Kean RB, Mikheeva T, Deka D, Karasev A, Cox S, Randall J, Koprowski H. Expression in plants and immunogenicity of plant virus-based experimental rabies vaccine. Vaccine. 2002 Aug 19; 20(25-26):3155-64. PMID: 12163267.
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    64. Hooper DC, Sauder C, Scott GS, Dietzschold B, Richt JA. Immunopathology and immunoprotection in CNS virus infections: mechanisms of virus clearance from the CNS. Curr Top Microbiol Immunol. 2002; 265:163-82. PMID: 12014188.
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    65. Alvarez-Mu?iz J, Halzen F, Han T, Hooper D. Phenomenology of high-energy neutrinos in low-scale quantum-gravity models. Phys Rev Lett. 2002 Jan 14; 88(2):021301. PMID: 11801000.
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    66. Pulmanausahakul R, Faber M, Morimoto K, Spitsin S, Weihe E, Hooper DC, Schnell MJ, Dietzschold B. Overexpression of cytochrome C by a recombinant rabies virus attenuates pathogenicity and enhances antiviral immunity. J Virol. 2001 Nov; 75(22):10800-7. PMID: 11602721.
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    67. Spitsin S, Hooper DC, Leist T, Streletz LJ, Mikheeva T, Koprowskil H. Inactivation of peroxynitrite in multiple sclerosis patients after oral administration of inosine may suggest possible approaches to therapy of the disease. Mult Scler. 2001 Oct; 7(5):313-9. PMID: 11724447.
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    68. Scott GS, Kean RB, Southan GJ, Szab? C, Hooper DC. Effect of mercaptoethylguanidine scavengers of peroxynitrite on the development of experimental allergic encephalomyelitis in PLSJL mice. Neurosci Lett. 2001 Sep 28; 311(2):125-8. PMID: 11567794.
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    69. Hooper DC, Kean RB, Scott GS, Spitsin SV, Mikheeva T, Morimoto K, Bette M, R?hrenbeck AM, Dietzschold B, Weihe E. The central nervous system inflammatory response to neurotropic virus infection is peroxynitrite dependent. J Immunol. 2001 Sep 15; 167(6):3470-7. PMID: 11544340.
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    70. Scott GS, Hake P, Kean RB, Vir?g L, Szab? C, Hooper DC. Role of poly(ADP-ribose) synthetase activation in the development of experimental allergic encephalomyelitis. J Neuroimmunol. 2001 Jul 02; 117(1-2):78-86. PMID: 11431007.
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    71. Spitsin S, Hooper DC, Mikheeva T, Koprowski H. Uric acid levels in patients with multiple sclerosis: analysis in mono- and dizygotic twins. Mult Scler. 2001 Jun; 7(3):165-6. PMID: 11475439.
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    72. Morimoto K, Schnell MJ, Pulmanausahakul R, McGettigan JP, Foley HD, Faber M, Hooper DC, Dietzschold B. High level expression of a human rabies virus-neutralizing monoclonal antibody by a rhabdovirus-based vector. J Immunol Methods. 2001 Jun 01; 252(1-2):199-206. PMID: 11334980.
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    73. Morimoto K, McGettigan JP, Foley HD, Hooper DC, Dietzschold B, Schnell MJ. Genetic engineering of live rabies vaccines. Vaccine. 2001 May 14; 19(25-26):3543-51. PMID: 11348722.
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    74. Prosniak M, Hooper DC, Dietzschold B, Koprowski H. Effect of rabies virus infection on gene expression in mouse brain. Proc Natl Acad Sci U S A. 2001 Feb 27; 98(5):2758-63. PMID: 11226313.
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    75. Dietzschold B, Morimoto K, Hooper DC. Mechanisms of virus-induced neuronal damage and the clearance of viruses from the CNS. Curr Top Microbiol Immunol. 2001; 253:145-55. PMID: 11417132.
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    76. Scott GS, Hooper DC. The role of uric acid in protection against peroxynitrite-mediated pathology. Med Hypotheses. 2001 Jan; 56(1):95-100. PMID: 11133262.
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    77. Kean RB, Spitsin SV, Mikheeva T, Scott GS, Hooper DC. The peroxynitrite scavenger uric acid prevents inflammatory cell invasion into the central nervous system in experimental allergic encephalomyelitis through maintenance of blood-central nervous system barrier integrity. J Immunol. 2000 Dec 01; 165(11):6511-8. PMID: 11086092.
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    78. Spitsin SV, Scott GS, Kean RB, Mikheeva T, Hooper DC. Protection of myelin basic protein immunized mice from free-radical mediated inflammatory cell invasion of the central nervous system by the natural peroxynitrite scavenger uric acid. Neurosci Lett. 2000 Oct 06; 292(2):137-41. PMID: 10998568.
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    79. Hooper DC, Scott GS, Zborek A, Mikheeva T, Kean RB, Koprowski H, Spitsin SV. Uric acid, a peroxynitrite scavenger, inhibits CNS inflammation, blood-CNS barrier permeability changes, and tissue damage in a mouse model of multiple sclerosis. FASEB J. 2000 Apr; 14(5):691-8. PMID: 10744626.
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    80. Champion JM, Kean RB, Rupprecht CE, Notkins AL, Koprowski H, Dietzschold B, Hooper DC. The development of monoclonal human rabies virus-neutralizing antibodies as a substitute for pooled human immune globulin in the prophylactic treatment of rabies virus exposure. J Immunol Methods. 2000 Feb 21; 235(1-2):81-90. PMID: 10675760.
      Citations:    
    81. Dietzschold B, Morimoto K, Hooper DC, Smith JS, Rupprecht CE, Koprowski H. Genotypic and phenotypic diversity of rabies virus variants involved in human rabies: implications for postexposure prophylaxis. J Hum Virol. 2000 Jan-Feb; 3(1):50-7. PMID: 10774807.
      Citations:    
    82. Eisenman LM, Brothers R, Tran MH, Kean RB, Dickson GM, Dietzschold B, Hooper DC. Neonatal Borna disease virus infection in the rat causes a loss of Purkinje cells in the cerebellum. J Neurovirol. 1999 Apr; 5(2):181-9. PMID: 10321982.
      Citations:    
    83. Morimoto K, Hooper DC, Spitsin S, Koprowski H, Dietzschold B. Pathogenicity of different rabies virus variants inversely correlates with apoptosis and rabies virus glycoprotein expression in infected primary neuron cultures. J Virol. 1999 Jan; 73(1):510-8. PMID: 9847357.
      Citations:    
    84. Dietzschold B, Hooper DC. Human diploid cell culture rabies vaccine (HDCV) and purified chick embryo cell culture rabies vaccine (PCECV) both confer protective immunity against infection with the silver-haired bat rabies virus strain (SHBRV). Vaccine. 1998 Oct; 16(17):1656-9. PMID: 9713943.
      Citations:    
    85. Hooper DC, Morimoto K, Bette M, Weihe E, Koprowski H, Dietzschold B. Collaboration of antibody and inflammation in clearance of rabies virus from the central nervous system. J Virol. 1998 May; 72(5):3711-9. PMID: 9557653.
      Citations:    
    86. Morimoto K, Hooper DC, Carbaugh H, Fu ZF, Koprowski H, Dietzschold B. Rabies virus quasispecies: implications for pathogenesis. Proc Natl Acad Sci U S A. 1998 Mar 17; 95(6):3152-6. PMID: 9501231.
      Citations:    
    87. Modelska A, Dietzschold B, Sleysh N, Fu ZF, Steplewski K, Hooper DC, Koprowski H, Yusibov V. Immunization against rabies with plant-derived antigen. Proc Natl Acad Sci U S A. 1998 Mar 03; 95(5):2481-5. PMID: 9482911.
      Citations:    
    88. Yang J, Hooper DC, Wunner WH, Koprowski H, Dietzschold B, Fu ZF. The specificity of rabies virus RNA encapsidation by nucleoprotein. Virology. 1998 Mar 01; 242(1):107-17. PMID: 9501055.
      Citations:    
    89. Hooper DC, Spitsin S, Kean RB, Champion JM, Dickson GM, Chaudhry I, Koprowski H. Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis. Proc Natl Acad Sci U S A. 1998 Jan 20; 95(2):675-80. PMID: 9435251.
      Citations:    
    90. Yusibov V, Modelska A, Steplewski K, Agadjanyan M, Weiner D, Hooper DC, Koprowski H. Antigens produced in plants by infection with chimeric plant viruses immunize against rabies virus and HIV-1. Proc Natl Acad Sci U S A. 1997 May 27; 94(11):5784-8. PMID: 9159151.
      Citations:    
    91. Hooper DC, Bagasra O, Marini JC, Zborek A, Ohnishi ST, Kean R, Champion JM, Sarker AB, Bobroski L, Farber JL, Akaike T, Maeda H, Koprowski H. Prevention of experimental allergic encephalomyelitis by targeting nitric oxide and peroxynitrite: implications for the treatment of multiple sclerosis. Proc Natl Acad Sci U S A. 1997 Mar 18; 94(6):2528-33. PMID: 9122229.
      Citations:    
    92. Morimoto K, Hooper DC, Bornhorst A, Corisdeo S, Bette M, Fu ZF, Sch?fer MK, Koprowski H, Weihe E, Dietzschold B. Intrinsic responses to Borna disease virus infection of the central nervous system. Proc Natl Acad Sci U S A. 1996 Nov 12; 93(23):13345-50. PMID: 8917593.
      Citations:    
    93. Morimoto K, Patel M, Corisdeo S, Hooper DC, Fu ZF, Rupprecht CE, Koprowski H, Dietzschold B. Characterization of a unique variant of bat rabies virus responsible for newly emerging human cases in North America. Proc Natl Acad Sci U S A. 1996 May 28; 93(11):5653-8. PMID: 8643632.
      Citations:    
    94. McGarvey PB, Hammond J, Dienelt MM, Hooper DC, Fu ZF, Dietzschold B, Koprowski H, Michaels FH. Expression of the rabies virus glycoprotein in transgenic tomatoes. Biotechnology (N Y). 1995 Dec; 13(13):1484-7. PMID: 9636308.
      Citations:    
    95. Hooper DC, Ohnishi ST, Kean R, Numagami Y, Dietzschold B, Koprowski H. Local nitric oxide production in viral and autoimmune diseases of the central nervous system. Proc Natl Acad Sci U S A. 1995 Jun 06; 92(12):5312-6. PMID: 7539914.
      Citations:    
    96. Dietzschold B, Schwaeble W, Sch?fer MK, Hooper DC, Zehng YM, Petry F, Sheng H, Fink T, Loos M, Koprowski H, Weihe E. Expression of C1q, a subcomponent of the rat complement system, is dramatically enhanced in brains of rats with either Borna disease or experimental allergic encephalomyelitis. J Neurol Sci. 1995 May; 130(1):11-6. PMID: 7544401.
      Citations:    
    97. Hooper DC, Pierard I, Modelska A, Otvos L, Fu ZF, Koprowski H, Dietzschold B. Rabies ribonucleocapsid as an oral immunogen and immunological enhancer. Proc Natl Acad Sci U S A. 1994 Nov 08; 91(23):10908-12. PMID: 7971982.
      Citations:    
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