Thomas Jefferson University

Deni S Galileo

TitleAssoc Prof CHP
InstitutionThomas Jefferson University
DepartmentNursing - Undergraduate
Address105 The Green
Newark DE 19716
Phone302-831-1277
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    F32NS008953     (GALILEO, DENI S)Jun 30, 1991
    NIH
    RETROVIRUS-MEDIATED GENE TRANSFER INTO BRAIN
    Role: Principal Investigator
    R01NS032346     (GALILEO, DENI S)Jul 1, 1994 - Jun 30, 1997
    NIH
    MECHANISMS OF CELL MIGRATION IN DEVELOPING BRAIN
    Role: Principal Investigator
    R21NS040317     (GALILEO, DENI S)Dec 15, 2001 - Nov 30, 2005
    NIH
    NgCAM/L1 misexpression in developing brain
    Role: Principal Investigator
    R03CA227312     (GALILEO, DENI S)Mar 1, 2018 - Feb 28, 2021
    NIH
    Elucidation of factors and mechanisms that promote glioblastoma stem cell motility and invasiveness
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Dutt R, Thorpe C, Galileo DS. QSOX1 Modulates Glioblastoma Cell Proliferation and Migration In Vitro and Invasion In Vivo. Cancers (Basel). 2024 Oct 26; 16(21). PMID: 39518060.
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    2. Pastorino NG, Tomatsu S, Lin A, Doerr J, Waterman Z, Sershen K, Ray P, Rodriguez A, Galileo DS. Using the Chick Embryo Brain as a Model for In Vivo and Ex Vivo Analyses of Human Glioblastoma Cell Behavior. J Vis Exp. 2023 05 26; (195). PMID: 37306427.
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    3. Rintz E, Higuchi T, Kobayashi H, Galileo DS, Wegrzyn G, Tomatsu S. Promoter considerations in the design of lentiviral vectors for use in treating lysosomal storage diseases. Mol Ther Methods Clin Dev. 2022 Mar 10; 24:71-87. PMID: 34977274.
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    4. Darrigues E, Zhao EH, De Loose A, Lee MP, Borrelli MJ, Eoff RL, Galileo DS, Penthala NR, Crooks PA, Rodriguez A. Biobanked Glioblastoma Patient-Derived Organoids as a Precision Medicine Model to Study Inhibition of Invasion. Int J Mol Sci. 2021 Oct 03; 22(19). PMID: 34639060.
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    5. Pace KR, Dutt R, Galileo DS. Exosomal L1CAM Stimulates Glioblastoma Cell Motility, Proliferation, and Invasiveness. Int J Mol Sci. 2019 Aug 16; 20(16). PMID: 31426278.
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    6. Pusey MA, Pace K, Fascelli M, Linser PJ, Steindler DA, Galileo DS. Ectopic expression of L1CAM ectodomain alters differentiation and motility, but not proliferation, of human neural progenitor cells. Int J Dev Neurosci. 2019 Aug 14; 78:49-64. PMID: 31421150.
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    7. Fereshteh Z, Bathala P, Galileo DS, Martin-DeLeon PA. Detection of extracellular vesicles in the mouse vaginal fluid: Their delivery of sperm proteins that stimulate capacitation and modulate fertility. J Cell Physiol. 2018 Dec 07. PMID: 30536802.
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    8. Bathala P, Fereshteh Z, Li K, Al-Dossary AA, Galileo DS, Martin-DeLeon PA. Oviductal extracellular vesicles (oviductosomes, OVS) are conserved in humans: murine OVS play a pivotal role in sperm capacitation and fertility. Mol Hum Reprod. 2018 Mar 01; 24(3):143-157. PMID: 29370405.
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    9. Caccavale J, Fiumara D, Stapf M, Sweitzer L, Anderson HJ, Gorky J, Dhurjati P, Galileo DS. A simple and accurate rule-based modeling framework for simulation of autocrine/paracrine stimulation of glioblastoma cell motility and proliferation by L1CAM in 2-D culture. BMC Syst Biol. 2017 Dec 11; 11(1):124. PMID: 29228953.
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    10. Viswanathan V, Damle S, Zhang T, Opdenaker L, Modarai S, Accerbi M, Schmidt S, Green P, Galileo D, Palazzo J, Fields J, Haghighat S, Rigoutsos I, Gonye G, Boman BM. An miRNA Expression Signature for the Human Colonic Stem Cell Niche Distinguishes Malignant from Normal Epithelia. Cancer Res. 2017 May 09. PMID: 28487386.
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    11. Olli KE, Li K, Galileo DS, Martin-DeLeon PA. Plasma membrane calcium ATPase 4 (PMCA4) co-ordinates calcium and nitric oxide signaling in regulating murine sperm functional activity. J Cell Physiol. 2017 Mar 01. PMID: 28247940.
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    12. Wu KZ, Li K, Galileo DS, Martin-DeLeon PA. Junctional adhesion molecule A: expression in the murine epididymal tract and accessory organs and acquisition by maturing sperm. Mol Hum Reprod. 2017 Feb 10; 23(2):132-140. PMID: 28062807.
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    13. Burgett ME, Lathia JD, Roth P, Nowacki AS, Galileo DS, Pugacheva E, Huang P, Vasanji A, Li M, Byzova T, Mikkelsen T, Bao S, Rich JN, Weller M, Gladson CL. Direct contact with perivascular tumor cells enhances integrin avß3 signaling and migration of endothelial cells. Oncotarget. 2016 Jul 12; 7(28):43852-43867. PMID: 27270311.
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    14. Anderson HJ, Galileo DS. Small-molecule inhibitors of FGFR, integrins and FAK selectively decrease L1CAM-stimulated glioblastoma cell motility and proliferation. Cell Oncol (Dordr). 2016 Jun; 39(3):229-42. PMID: 26883759.
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    15. Andrews RE, Galileo DS, Martin-DeLeon PA. Plasma membrane Ca2+-ATPase 4: interaction with constitutive nitric oxide synthases in human sperm and prostasomes which carry Ca2+/CaM-dependent serine kinase. Mol Hum Reprod. 2015 Nov; 21(11):832-43. PMID: 26345709.
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    16. Smith MA, Michael R, Aravindan RG, Dash S, Shah SI, Galileo DS, Martin-DeLeon PA. Anatase titanium dioxide nanoparticles in mice: evidence for induced structural and functional sperm defects after short-, but not long-, term exposure. Asian J Androl. 2015 Mar-Apr; 17(2):261-8. PMID: 25370207.
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    17. Modelski MJ, Menlah G, Wang Y, Dash S, Wu K, Galileo DS, Martin-DeLeon PA. Hyaluronidase 2: a novel germ cell hyaluronidase with epididymal expression and functional roles in Mammalian sperm. Biol Reprod. 2014 Nov; 91(5):109. PMID: 25232017.
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    18. Patel R, Al-Dossary AA, Stabley DL, Barone C, Galileo DS, Strehler EE, Martin-Deleon PA. Plasma Membrane Ca2+-ATPase 4 in Murine Epididymis: Secretion of Splice Variants in the Luminal Fluid and a Role in Sperm Maturation. Biol Reprod. 2013; 89(1):6. PMID: 23699388.
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    19. Mohanan V, Temburni MK, Kappes JC, Galileo DS. L1CAM stimulates glioma cell motility and proliferation through the fibroblast growth factor receptor. Clin Exp Metastasis. 2013 Apr; 30(4):507-20. PMID: 23212305.
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    20. Aravindan RG, Fomin VP, Naik UP, Modelski MJ, Naik MU, Galileo DS, Duncan RL, Martin-Deleon PA. CASK interacts with PMCA4b and JAM-A on the mouse sperm flagellum to regulate Ca2+ homeostasis and motility. J Cell Physiol. 2012 Aug; 227(8):3138-50. PMID: 22020416.
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    21. Yang M, Li Y, Chilukuri K, Brady OA, Boulos MI, Kappes JC, Galileo DS. L1 stimulation of human glioma cell motility correlates with FAK activation. J Neurooncol. 2011 Oct; 105(1):27-44. PMID: 21373966.
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    22. Li Y, Galileo DS. Soluble L1CAM promotes breast cancer cell adhesion and migration in vitro, but not invasion. Cancer Cell Int. 2010; 10:34. PMID: 20840789.
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    23. Reese KL, Aravindan RG, Griffiths GS, Shao M, Wang Y, Galileo DS, Atmuri V, Triggs-Raine BL, Martin-Deleon PA. Acidic hyaluronidase activity is present in mouse sperm and is reduced in the absence of SPAM1: evidence for a role for hyaluronidase 3 in mouse and human sperm. Mol Reprod Dev. 2010 Sep; 77(9):759-72. PMID: 20586096.
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    24. Sauers DJ, Temburni MK, Biggins JB, Ceo LM, Galileo DS, Koh JT. Light-activated gene expression directs segregation of co-cultured cells in vitro. ACS Chem Biol. 2010 Mar 19; 5(3):313-20. PMID: 20050613.
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    25. Yang M, Adla S, Temburni MK, Patel VP, Lagow EL, Brady OA, Tian J, Boulos MI, Galileo DS. Stimulation of glioma cell motility by expression, proteolysis, and release of the L1 neural cell recognition molecule. Cancer Cell Int. 2009; 9:27. PMID: 19874583.
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    26. Griffiths GS, Galileo DS, Aravindan RG, Martin-DeLeon PA. Clusterin facilitates exchange of glycosyl phosphatidylinositol-linked SPAM1 between reproductive luminal fluids and mouse and human sperm membranes. Biol Reprod. 2009 Sep; 81(3):562-70. PMID: 19357365.
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    27. Farach AM, Galileo DS. O-GlcNAc modification of radial glial vimentin filaments in the developing chick brain. Brain Cell Biol. 2008 Dec; 36(5-6):191-202. PMID: 19132533.
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    28. Griffiths GS, Galileo DS, Reese K, Martin-Deleon PA. Investigating the role of murine epididymosomes and uterosomes in GPI-linked protein transfer to sperm using SPAM1 as a model. Mol Reprod Dev. 2008 Nov; 75(11):1627-36. PMID: 18384048.
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    29. Griffiths GS, Miller KA, Galileo DS, Martin-DeLeon PA. Murine SPAM1 is secreted by the estrous uterus and oviduct in a form that can bind to sperm during capacitation: acquisition enhances hyaluronic acid-binding ability and cumulus dispersal efficiency. Reproduction. 2008 Mar; 135(3):293-301. PMID: 18299422.
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    30. Tian J, Paquette-Straub C, Sage EH, Funk SE, Patel V, Galileo D, McLane MA. Inhibition of melanoma cell motility by the snake venom disintegrin eristostatin. Toxicon. 2007 Jun 1; 49(7):899-908. PMID: 17316731.
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    31. Fotos JS, Patel VP, Karin NJ, Temburni MK, Koh JT, Galileo DS. Automated time-lapse microscopy and high-resolution tracking of cell migration. Cytotechnology. 2006 May; 51(1):7-19. PMID: 19002890.
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    32. Masiello LM, Fotos JS, Galileo DS, Karin NJ. Lysophosphatidic acid induces chemotaxis in MC3T3-E1 osteoblastic cells. Bone. 2006 Jul; 39(1):72-82. PMID: 16487757.
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    33. Chen H, Griffiths G, Galileo DS, Martin-DeLeon PA. Epididymal SPAM1 is a marker for sperm maturation in the mouse. Biol Reprod. 2006 May; 74(5):923-30. PMID: 16436526.
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    34. Martin-DeLeon PA, Zhang H, Morales CR, Zhao Y, Rulon M, Barnoski BL, Chen H, Galileo DS. Spam1-associated transmission ratio distortion in mice: elucidating the mechanism. Reprod Biol Endocrinol. 2005; 3:32. PMID: 16092963.
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    35. Castellini M, Wolf LV, Chauhan BK, Galileo DS, Kilimann MW, Cvekl A, Duncan MK. Palm is expressed in both developing and adult mouse lens and retina. BMC Ophthalmol. 2005; 5:14. PMID: 15969763.
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    36. Morgan JC, Majors JE, Galileo DS. Distinct and opposite roles for SH2 and SH3 domains of v-src in embryo survival and hemangiosarcoma formation. Clin Exp Metastasis. 2005; 22(2):167-75. PMID: 16086237.
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    37. Cretu A, Fotos JS, Little BW, Galileo DS. Human and rat glioma growth, invasion, and vascularization in a novel chick embryo brain tumor model. Clin Exp Metastasis. 2005; 22(3):225-36. PMID: 16158250.
      Citations:    
    38. Stettler EM, Galileo DS. Radial glia produce and align the ligand fibronectin during neuronal migration in the developing chick brain. J Comp Neurol. 2004 Jan 12; 468(3):441-51. PMID: 14681936.
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    39. Galileo DS. Spatiotemporal gradient of oligodendrocyte differentiation in chick optic tectum requires brain integrity and cell-cell interactions. Glia. 2003 Jan; 41(1):25-37. PMID: 12465043.
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    40. Galileo DS, Morrill JB. Patterns of cells and extracellular material of the sea urchin Lytechinus variegatus (Echinodermata; Echinoidea) embryo, from hatched blastula to late gastrula. J Morphol. 1985 Sep; 185(3):387-402. PMID: 29991195.
      Citations:    
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