Thomas Jefferson University

Dennis Leeper

TitleAssoc Prof CHP
InstitutionThomas Jefferson University
DepartmentNursing - Undergraduate
Address111 S. 11th Street
Philadelphia PA 19107
Phone215-955-8092
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    Collapse Research 
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    P01CA056690     (LEEPER, DENNIS B.)Mar 31, 2009
    NIH
    Modification of hyperthermia response
    Role: Principal Investigator
    T32CA009137     (LEEPER, DENNIS B)Jul 1, 1978 - May 31, 2004
    NIH
    CANCER TRAINING IN THE SCIENCE OF DNA DAMAGE RESPONSE
    Role: Principal Investigator
    R01CA039487     (LEEPER, DENNIS B)Sep 1, 1985 - Aug 31, 1988
    NIH
    THERMOTOLERANCE, PROTEIN SYNTHESIS, AND STEPDOWN HEATING
    Role: Principal Investigator
    R01CA042210     (LEEPER, DENNIS B)May 1, 1987 - Mar 31, 1991
    NIH
    HYPERTHERMIA RESPONSE OF BONE MARROW STEM CELLS
    Role: Principal Investigator
    R01CA044431     (LEEPER, DENNIS B)May 1, 1987 - Mar 31, 1991
    NIH
    PH, HYPERGLYCEMIA AND HYPERTHERMIA IN HUMAN TUMORS
    Role: Principal Investigator
    R13CA049370     (LEEPER, DENNIS B)Sep 7, 1988 - Sep 6, 1989
    NIH
    5TH INTERNATIONAL SYMPOSIUM--HYPERTHERMIC ONCOLOGY
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Leeper DB, Dewhirst MW. Obituary. Int J Hyperthermia. 2024; 41(1):2283909. PMID: 38159560.
      Citations:    
    2. Lacerda Q, Falatah H, Liu JB, Wessner CE, Oeffinger B, Rochani A, Leeper DB, Forsberg F, Curry JM, Kaushal G, Keith SW, O'Kane P, Wheatley MA, Eisenbrey JR. Improved Tumor Control Following Radiosensitization with Ultrasound-Sensitive Oxygen Microbubbles and Tumor Mitochondrial Respiration Inhibitors in a Preclinical Model of Head and Neck Cancer. Pharmaceutics. 2023 Apr 21; 15(4). PMID: 37111787.
      Citations:    
    3. Lacerda Q, Rochani A, Oeffinger B, Liu JB, Wessner CE, Tahmasebi A, Falatah H, Lee P, Leeper DB, Forsberg F, Curry J, Keith SW, O'Kane P, Kaushal G, Wheatley MA, Eisenbrey JR. Tumoral oxygenation and biodistribution of Lonidamine oxygen microbubbles following localized ultrasound-triggered delivery. Int J Pharm. 2022 Sep 25; 625:122072. PMID: 35932933.
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    4. Leeper D, Spitz D, Dynlacht J, Corry P. William C. Dewey, PhDNovember 4, 1929-November 15, 2021. Radiat Res. 2022 Jun 01; 197(6):673-677. PMID: 35512305.
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    5. Leeper D, Spitz D, Dynlacht J. In memoriam: William C. Dewey, PhD. Int J Radiat Biol. 2022 May 23; 1-2. PMID: 35544721.
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    6. Falatah HA, Lacerda Q, Chaga M, Wessner CE, Forsberg F, Leeper DB, Eisenbrey JR. Activation of Phase Change Contrast Agents Using Ionizing Radiation. J Ultrasound Med. 2021 Dec 06. PMID: 34866197.
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    7. Lacerda Q, Tantawi M, Leeper DB, Wheatley MA, Eisenbrey JR. Emerging Applications of Ultrasound-Contrast Agents in Radiation Therapy. Ultrasound Med Biol. 2021 Jun; 47(6):1465-1474. PMID: 33653626.
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    8. Stauffer PR, Rodrigues DB, Goldstein R, Nguyen T, Yu Y, Wan S, Woodward R, Gibbs M, Vasilchenko IL, Osintsev AM, Bar-Ad V, Leeper DB, Shi W, Judy KD, Hurwitz MD. Feasibility of removable balloon implant for simultaneous magnetic nanoparticle heating and HDR brachytherapy of brain tumor resection cavities. Int J Hyperthermia. 2020; 37(1):1189-1201. PMID: 33047639.
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    9. Delaney LJ, Ciraku L, Oeffinger BE, Wessner CE, Liu JB, Li J, Nam K, Forsberg F, Leeper DB, O'Kane P, Wheatley MA, Reginato MJ, Eisenbrey JR. Breast Cancer Brain Metastasis Response to Radiation After Microbubble Oxygen Delivery in a Murine Model. J Ultrasound Med. 2019 May 23. PMID: 31124171.
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    10. Nath K, Roman J, Nelson DS, Guo L, Lee SC, Orlovskiy S, Muriuki K, Heitjan DF, Pickup S, Leeper DB, Blair IA, Putt ME, Glickson JD. Effect of Differences in Metabolic Activity of Melanoma Models on Response to Lonidamine plus Doxorubicin. Sci Rep. 2018 Oct 02; 8(1):14654. PMID: 30279592.
      Citations:    
    11. Eisenbrey JR, Shraim R, Liu JB, Li J, Stanczak M, Oeffinger B, Leeper DB, Keith SW, Jablonowski LJ, Forsberg F, O'Kane P, Wheatley MA. Sensitization of Hypoxic Tumors to Radiation Therapy Using Ultrasound-Sensitive Oxygen Microbubbles. Int J Radiat Oncol Biol Phys. 2018 Jan 31. PMID: 29477294.
      Citations:    
    12. Daecher A, Stanczak M, Liu JB, Zhang J, Du S, Forsberg F, Leeper DB, Eisenbrey JR. Localized microbubble cavitation-based antivascular therapy for improving HCC treatment response to radiotherapy. Cancer Lett. 2017 Dec 28; 411:100-105. PMID: 28969964.
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    13. Nath K, Nelson DS, Roman J, Putt ME, Lee SC, Leeper DB, Glickson JD. Effect of Lonidamine on Systemic Therapy of DB-1 Human Melanoma Xenografts with Temozolomide. Anticancer Res. 2017 Jul; 37(7):3413-3421. PMID: 28668829.
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    14. Nath K, Guo L, Nancolas B, Nelson DS, Shestov AA, Lee SC, Roman J, Zhou R, Leeper DB, Halestrap AP, Blair IA, Glickson JD. Mechanism of antineoplastic activity of lonidamine. Biochim Biophys Acta. 2016 Aug 4; 1866(2):151-162. PMID: 27497601.
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    15. Du S, Lockamy V, Zhou L, Xue C, LeBlanc J, Glenn S, Shukla G, Yu Y, Dicker AP, Leeper DB, Lu Y, Lu B. Stereotactic Body Radiation Therapy Delivery in a Genetically Engineered Mouse Model of Lung Cancer. Int J Radiat Oncol Biol Phys. 2016 Nov 1; 96(3):529-37. PMID: 27681749.
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    16. Shestov AA, Lee SC, Nath K, Guo L, Nelson DS, Roman JC, Leeper DB, Wasik MA, Blair IA, Glickson JD. (13)C MRS and LC-MS Flux Analysis of Tumor Intermediary Metabolism. Front Oncol. 2016; 6:135. PMID: 27379200.
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    17. Nath K, Nelson DS, Putt ME, Leeper DB, Garman B, Nathanson KL, Glickson JD. Comparison of the Lonidamine Potentiated Effect of Nitrogen Mustard Alkylating Agents on the Systemic Treatment of DB-1 Human Melanoma Xenografts in Mice. PLoS One. 2016; 11(6):e0157125. PMID: 27285585.
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    18. Nancolas B, Guo L, Zhou R, Nath K, Nelson DS, Leeper DB, Blair IA, Glickson JD, Halestrap AP. The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters. Biochem J. 2016 Apr 1; 473(7):929-36. PMID: 26831515.
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    19. Shestov AA, Mancuso A, Lee SC, Guo L, Nelson DS, Roman JC, Henry PG, Leeper DB, Blair IA, Glickson JD. Bonded Cumomer Analysis of Human Melanoma Metabolism Monitored by 13C NMR Spectroscopy of Perfused Tumor Cells. J Biol Chem. 2016 Mar 4; 291(10):5157-71. PMID: 26703469.
      Citations:    
    20. Guo L, Shestov AA, Worth AJ, Nath K, Nelson DS, Leeper DB, Glickson JD, Blair IA. Inhibition of Mitochondrial Complex II by the Anticancer Agent Lonidamine. J Biol Chem. 2016 Jan 1; 291(1):42-57. PMID: 26521302.
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    21. Nath K, Nelson DS, Heitjan DF, Zhou R, Leeper DB, Glickson JD. Effects of hyperglycemia on lonidamine-induced acidification and de-energization of human melanoma xenografts and sensitization to melphalan. NMR Biomed. 2015 Mar; 28(3):395-403. PMID: 25702942.
      Citations:    
    22. Nath K, Nelson DS, Heitjan DF, Leeper DB, Zhou R, Glickson JD. Lonidamine induces intracellular tumor acidification and ATP depletion in breast, prostate and ovarian cancer xenografts and potentiates response to doxorubicin. NMR Biomed. 2015 Mar; 28(3):281-90. PMID: 25504852.
      Citations:    
    23. Coss RA, Storck CW, Wells TC, Kulp KA, Wahl M, Leeper DB. Thermal sensitisation by lonidamine of human melanoma cells grown at low extracellular pH. Int J Hyperthermia. 2014 Feb; 30(1):75-8. PMID: 24295212.
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    24. Nath K, Nelson DS, Ho AM, Lee SC, Darpolor MM, Pickup S, Zhou R, Heitjan DF, Leeper DB, Glickson JD. (31) P and (1) H MRS of DB-1 melanoma xenografts: lonidamine selectively decreases tumor intracellular pH and energy status and sensitizes tumors to melphalan. NMR Biomed. 2013 Jan; 26(1):98-105. PMID: 22745015.
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    25. Mendoza EE, Pocceschi MG, Kong X, Leeper DB, Caro J, Limesand KH, Burd R. Control of Glycolytic Flux by AMP-Activated Protein Kinase in Tumor Cells Adapted to Low pH. Transl Oncol. 2012 Jun; 5(3):208-16. PMID: 22741040.
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    26. Li LZ, Zhou R, Leeper DB, Glickson JD. ³¹P-MRS studies of melanoma xenografts with different metastatic potential. Adv Exp Med Biol. 2011; 701:69-73. PMID: 21445771.
      Citations:    
    27. Li LZ, Zhou R, Xu HN, Moon L, Zhong T, Kim EJ, Qiao H, Reddy R, Leeper D, Chance B, Glickson JD. Quantitative magnetic resonance and optical imaging biomarkers of melanoma metastatic potential. Proc Natl Acad Sci U S A. 2009 Apr 21; 106(16):6608-13. PMID: 19366661.
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    28. Sugahara T, van der Zee J, Kampinga HH, Vujaskovic Z, Kondo M, Ohnishi T, Li G, Park HJ, Leeper DB, Ostapenko V, Repasky EA, Watanabe M, Song CW. Kadota Fund International Forum 2004. Application of thermal stress for the improvement of health, 15-18 June 2004, Awaji Yumebutai International Conference Center, Awaji Island, Hyogo, Japan. Final report. Int J Hyperthermia. 2008 Mar; 24(2):123-40. PMID: 18283589.
      Citations:    
    29. Li LZ, Zhou R, Zhong T, Moon L, Kim EJ, Qiao H, Pickup S, Hendrix MJ, Leeper D, Chance B, Glickson JD. Predicting melanoma metastatic potential by optical and magnetic resonance imaging. Adv Exp Med Biol. 2007; 599:67-78. PMID: 17727249.
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    30. Biaglow J, Dewhirst M, Leeper D, Burd R, Tuttle S. Factors controlling oxygen utilization. Adv Exp Med Biol. 2005; 566:317-23. PMID: 16594168.
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    31. Canter RJ, Zhou R, Kesmodel SB, Zhang Y, Heitjan DF, Glickson JD, Leeper DB, Fraker DL. Metaiodobenzylguanidine and hyperglycemia augment tumor response to isolated limb perfusion in a rodent model of human melanoma. Ann Surg Oncol. 2004 Mar; 11(3):265-73. PMID: 14993021.
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    32. Burd R, Lavorgna SN, Daskalakis C, Wachsberger PR, Wahl ML, Biaglow JE, Stevens CW, Leeper DB. Tumor oxygenation and acidification are increased in melanoma xenografts after exposure to hyperglycemia and meta-iodo-benzylguanidine. Radiat Res. 2003 Mar; 159(3):328-35. PMID: 12600235.
      Citations:    
    33. Lee I, Glickson JD, Dewhirst MW, Leeper DB, Burd R, Poptani H, Nadal L, McKenna WG, Biaglow JE. Effect of mild hyperglycemia +/- meta-iodo-benzylguanidine on the radiation response of R3230 Ac tumors. Adv Exp Med Biol. 2003; 530:177-86. PMID: 14562715.
      Citations:    
    34. Wahl ML, Owen JA, Burd R, Herlands RA, Nogami SS, Rodeck U, Berd D, Leeper DB, Owen CS. Regulation of intracellular pH in human melanoma: potential therapeutic implications. Mol Cancer Ther. 2002 Jun; 1(8):617-28. PMID: 12479222.
      Citations:    
    35. Guan J, Stavridi E, Leeper DB, Iliakis G. Effects of hyperthermia on p53 protein expression and activity. J Cell Physiol. 2002 Mar; 190(3):365-74. PMID: 11857452.
      Citations:    
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