Thomas Jefferson University

Dessislava Markova

TitleAsst Professor
InstitutionThomas Jefferson University
DepartmentOrthopedic Surgery
Address1015 Walnut St.
Philadelphia PA 19107
Phone215-955-7655
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Divi SN, Markova DZ, D'Antonio ND, Lambrechts MJ, Levy HA, Heard JC, Yalla GR, Chang M, Hilibrand AS, Vaccaro AR, Kepler CK. Circulating microRNAs May Be Predictive of Degenerative Cervical Myelopathy. Spine (Phila Pa 1976). 2024 May 06. PMID: 38711175.
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    2. Lambrechts MJ, D'Antonio ND, Heard JC, Yalla G, Karamian BA, Markova DZ, Kepler CK. The Inhibitory Effect of NSAIDs and Opioids on Spinal Fusion: An animal model. Spine (Phila Pa 1976). 2024 Feb 13. PMID: 38348858.
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    3. Canseco JA, Levy HA, Karamian BA, Blaber O, Chang M, Patel N, Curran J, Hilibrand AS, Schroeder GD, Vaccaro AR, Markova DZ, Surrey DE, Kepler CK. Inhibition of Neurogenic Inflammatory Pathways Associated with the Reduction in Discogenic Back Pain. Asian Spine J. 2023 Dec 05. PMID: 38050358.
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    4. Karamian BA, Levy HA, Yalla GR, D'Antonio ND, Heard JC, Lambrechts MJ, Canseco JA, Vaccaro AR, Markova DZ, Kepler CK. Varenicline Mitigates the Increased Risk of Pseudoarthrosis Associated with Nicotine. Spine J. 2023 Apr 20. PMID: 37086977.
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    5. Karamian BA, Levy HA, Boere P, Yalla GR, Canseco JA, Chang M, Divi SN, Fang T, Millhouse PW, Lendner M, Hilibrand AS, Vaccaro AR, Kepler CK, Markova DZ, Schroeder GD. Do Inflammatory Cytokines Affect Patient Outcomes After ACDF? Clin Spine Surg. 2022 05 01; 35(4):137-143. PMID: 35351842.
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    6. Brent JM, Tian Z, Yao L, Huang J, Markova DZ, Shofer FS, Brice AK, Qin L, Scanzello CR, Vitale F, Chen D, Zhang Y. Functional Deficits in Mice Expressing Human Interleukin 8. Comp Med. 2020 Apr 20. PMID: 32312361.
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    7. Koerner JD, Markova DZ, Schroeder GD, Antonacci CL, Mendelis J, Vaccaro AR, Anderson DG, Kepler CK. Correlation of Early Outcomes and Intradiscal Interleukin-6 Expression in Lumbar Fusion Patients. Neurospine. 2020 Mar; 17(1):36-41. PMID: 32252153.
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    8. Hong J, Li S, Markova DZ, Liang A, Kepler CK, Huang Y, Zhou J, Yan J, Chen W, Huang D, Xu K, Ye W. Bromodomain-containing protein 4 inhibition alleviates matrix degradation by enhancing autophagy and suppressing NLRP3 inflammasome activity in NP cells. J Cell Physiol. 2020 Jan 24. PMID: 31975410.
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    9. Divi SN, Markova DZ, Fang T, Guzek R, Kurd MF, Rihn JA, Hilibrand AS, Anderson DG, Vaccaro AR, Schroeder GD, Kepler CK. Circulating miR-155-5p as a Novel Biomarker of Lumbar Degenerative Disc Disease. Spine (Phila Pa 1976). 2019 Nov 18. PMID: 31770330.
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    10. Schroeder GD, Kepler CK, Grad S, Alini M, Fang T, Markova DZ, Koerner JD, Rajasekaran S, Chapman J, Kandziora F, Schnake KJ, Dvorak MF, Oner FC, Vaccaro AR. Does Riluzole Influence Bone Formation? An in vitro Study of Human Mesenchymal Stromal Cells and Osteoblast. Spine (Phila Pa 1976). 2019 Mar 01. PMID: 30896584.
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    11. Zhou J, Sun J, Markova DZ, Li S, Kepler CK, Hong J, Huang Y, Chen W, Xu K, Wei F, Ye W. MicroRNA-145 overexpression attenuates apoptosis and increases matrix synthesis in nucleus pulposus cells. Life Sci. 2019 Mar 15; 221:274-283. PMID: 30797016.
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    12. Koerner JD, Markova DZ, Schroeder GD, Calio BP, Shah A, Brooks CW, Vaccaro AR, Anderson DG, Kepler CK. The local cytokine and growth factor response to rhBMP-2 after spinal fusion. Spine J. 2018 Mar 14. PMID: 29550606.
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    13. Koerner JD, Markova DZ, Schroeder GD, Rihn JA, Hilibrand AS, Vaccaro AR, Anderson DG, Kepler CK. The Effect of Substance P on an Intervertebral Disc Rat Organ Culture Model. Spine (Phila Pa 1976). 2016 Dec 15; 41(24):1851-1859. PMID: 27163370.
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    14. Schroeder GD, Markova DZ, Koerner JD, Rihn JA, Hilibrand AS, Vaccaro AR, Anderson DG, Kepler CK. Are Modic changes associated with intervertebral disc cytokine profiles? Spine J. 2017 Jan; 17(1):129-134. PMID: 27497891.
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    15. Zhang Y, Chee A, Shi P, Adams SL, Markova DZ, Anderson DG, Smith HE, Deng Y, Plastaras CT, An HS. Intervertebral Disc Cells Produce Interleukins Found in Patients with Back Pain. Am J Phys Med Rehabil. 2016 Jun; 95(6):407-15. PMID: 26495812.
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    16. Markova DZ, Pan TC, Zhang RZ, Zhang G, Sasaki T, Arita M, Birk DE, Chu ML. Forelimb contractures and abnormal tendon collagen fibrillogenesis in fibulin-4 null mice. Cell Tissue Res. 2016 Jun; 364(3):637-46. PMID: 26711913.
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    17. Kepler CK, Markova DZ, Koerner JD, Mendelis J, Chen CM, Vaccaro AR, Risbud MV, Albert TJ, Anderson DG. Substance P Receptor Antagonist Suppresses Inflammatory Cytokine Expression in Human Disc Cells. Spine (Phila Pa 1976). 2015 Aug 15; 40(16):1261-9. PMID: 25929203.
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    18. Johnson ZI, Gogate SS, Day R, Binch A, Markova DZ, Chiverton N, Cole A, Conner M, Shapiro IM, Le Maitre CL, Risbud MV. Aquaporin 1 and 5 expression decreases during human intervertebral disc degeneration: Novel HIF-1-mediated regulation of aquaporins in NP cells. Oncotarget. 2015 May 20; 6(14):11945-58. PMID: 25844601.
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    19. Scanzello CR, Markova DZ, Chee A, Xiu Y, Adams SL, Anderson G, Zgonis M, Qin L, An HS, Zhang Y. Fibronectin splice variation in human knee cartilage, meniscus and synovial membrane: Observations in osteoarthritic knee. J Orthop Res. 2015 Apr; 33(4):556-62. PMID: 25410897.
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    20. Ye W, Zhou J, Markova DZ, Tian Y, Li J, Anderson DG, Shapiro IM, Risbud MV. Xylosyltransferase-1 Expression Is Refractory to Inhibition by the Inflammatory Cytokines Tumor Necrosis Factor a and IL-1ß in Nucleus Pulposus Cells: Novel Regulation by AP-1, Sp1, and Sp3. Am J Pathol. 2015 Feb; 185(2):485-95. PMID: 25476526.
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    21. Koerner JD, Markova DZ, Yadla S, Mendelis J, Hilibrand A, Vaccaro AR, Risbud MV, Albert TJ, Anderson DG, Kepler CK. Differential gene expression in anterior and posterior annulus fibrosus. Spine (Phila Pa 1976). 2014 Nov 1; 39(23):1917-23. PMID: 25365709.
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    22. Hirose Y, Johnson ZI, Schoepflin ZR, Markova DZ, Chiba K, Toyama Y, Shapiro IM, Risbud MV. FIH-1-Mint3 axis does not control HIF-1 transcriptional activity in nucleus pulposus cells. J Biol Chem. 2014 Jul 25; 289(30):20594-605. PMID: 24867948.
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    23. Ruel N, Markova DZ, Adams SL, Scanzello C, Cs-Szabo G, Gerard D, Shi P, Anderson DG, Zack M, An HS, Chen D, Zhang Y. Fibronectin Fragments and the Cleaving Enzyme ADAM-8 in the Degenerative Human Intervertebral Disc. Spine (Phila Pa 1976). 2014 Jul 15; 39(16):1274-9. PMID: 25010013.
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    24. Tran CM, Schoepflin ZR, Markova DZ, Kepler CK, Anderson DG, Shapiro IM, Risbud MV. CCN2 Suppresses Catabolic Effects of Interleukin-1ß through a5ß1 and aVß3 Integrins in Nucleus Pulposus Cells: IMPLICATIONS IN INTERVERTEBRAL DISC DEGENERATION. J Biol Chem. 2014 Mar 14; 289(11):7374-87. PMID: 24464580.
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    25. Kepler CK, Markova DZ, Hilibrand AS, Vaccaro AR, Risbud MV, Albert TJ, Anderson DG. Substance P stimulates production of inflammatory cytokines in human disc cells. Spine (Phila Pa 1976). 2013 Oct 1; 38(21):E1291-9. PMID: 23873242.
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    26. Kepler CK, Markova DZ, Dibra F, Yadla S, Vaccaro AR, Risbud MV, Albert TJ, Anderson DG. Expression and Relationship of Proinflammatory Chemokine RANTES/CCL5 and Cytokine IL-1ß in Painful Human Intervertebral Discs. Spine (Phila Pa 1976). 2013 May 15; 38(11):873-80. PMID: 23660804.
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    27. Anderson DG, Markova D, An HS, Chee A, Enomoto-Iwamoto M, Markov V, Saitta B, Shi P, Gupta C, Zhang Y. Human umbilical cord blood-derived mesenchymal stem cells in the cultured rabbit intervertebral disc: a novel cell source for disc repair. Am J Phys Med Rehabil. 2013 May; 92(5):420-9. PMID: 23598901.
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    28. Pan TC, Zhang RZ, Markova D, Arita M, Zhang Y, Bogdanovich S, Khurana TS, Bönnemann CG, Birk DE, Chu ML. COL6A3 Protein Deficiency in Mice Leads to Muscle and Tendon Defects Similar to Human Collagen VI Congenital Muscular Dystrophy. J Biol Chem. 2013 May 17; 288(20):14320-31. PMID: 23564457.
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    29. Markova DZ, Kepler CK, Addya S, Murray HB, Vaccaro AR, Shapiro IM, Anderson DG, Albert TJ, Risbud MV. An organ culture system to model early degenerative changes of the intervertebral disc II: profiling global gene expression changes. Arthritis Res Ther. 2013; 15(5):R121. PMID: 24171898.
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    30. Fujita N, Markova D, Anderson DG, Chiba K, Toyama Y, Shapiro IM, Risbud MV. Expression of prolyl hydroxylases (PHDs) is selectively controlled by HIF-1 and HIF-2 proteins in nucleus pulposus cells of the intervertebral disc: distinct roles of PHD2 and PHD3 proteins in controlling HIF-1a activity in hypoxia. J Biol Chem. 2012 May 11; 287(20):16975-86. PMID: 22451659.
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    31. Tsuda T, Wu J, Gao E, Joyce J, Markova D, Dong H, Liu Y, Zhang H, Zou Y, Gao F, Miller T, Koch W, Ma X, Chu ML. Loss of fibulin-2 protects against progressive ventricular dysfunction after myocardial infarction. J Mol Cell Cardiol. 2012 Jan; 52(1):273-82. PMID: 22100229.
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    32. Ponnappan RK, Markova DZ, Antonio PJ, Murray HB, Vaccaro AR, Shapiro IM, Anderson DG, Albert TJ, Risbud MV. An organ culture system to model early degenerative changes of the intervertebral disc. Arthritis Res Ther. 2011; 13(5):R171. PMID: 22018279.
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    33. Wang J, Markova D, Anderson DG, Zheng Z, Shapiro IM, Risbud MV. TNF-a and IL-1ß promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc. J Biol Chem. 2011 Nov 18; 286(46):39738-49. PMID: 21949132.
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    34. Zhang Y, Drapeau S, An HS, Markova D, Lenart BA, Anderson DG. Histological features of the degenerating intervertebral disc in a goat disc-injury model. Spine (Phila Pa 1976). 2011 Sep 1; 36(19):1519-27. PMID: 21245789.
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    35. Hiyama A, Skubutyte R, Markova D, Anderson DG, Yadla S, Sakai D, Mochida J, Albert TJ, Shapiro IM, Risbud MV. Hypoxia activates the notch signaling pathway in cells of the intervertebral disc: implications in degenerative disc disease. Arthritis Rheum. 2011 May; 63(5):1355-64. PMID: 21305512.
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    36. Skubutyte R, Markova D, Freeman TA, Anderson DG, Dion AS, Williams CJ, Shapiro IM, Risbud MV. Hypoxia-inducible factor regulation of ANK expression in nucleus pulposus cells: possible implications in controlling dystrophic mineralization in the intervertebral disc. Arthritis Rheum. 2010 Sep; 62(9):2707-15. PMID: 20496369.
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    37. Anderson DG, Markova D, Adams SL, Pacifici M, An HS, Zhang Y. Fibronectin splicing variants in human intervertebral disc and association with disc degeneration. Spine (Phila Pa 1976). 2010 Aug 1; 35(17):1581-8. PMID: 20628340.
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    38. Tran CM, Markova D, Smith HE, Susarla B, Ponnappan RK, Anderson DG, Symes A, Shapiro IM, Risbud MV. Regulation of CCN2/connective tissue growth factor expression in the nucleus pulposus of the intervertebral disc: role of Smad and activator protein 1 signaling. Arthritis Rheum. 2010 Jul; 62(7):1983-92. PMID: 20222112.
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    39. Zhang RZ, Zou Y, Pan TC, Markova D, Fertala A, Hu Y, Squarzoni S, Reed UC, Marie SK, Bönnemann CG, Chu ML. Recessive COL6A2 C-globular missense mutations in Ullrich congenital muscular dystrophy: role of the C2a splice variant. J Biol Chem. 2010 Mar 26; 285(13):10005-15. PMID: 20106987.
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    40. Zhang Y, Markova D, Im HJ, Hu W, Thonar EJ, He TC, An HS, Phillips FM, Anderson DG. Primary bovine intervertebral disc cells transduced with adenovirus overexpressing 12 BMPs and Sox9 maintain appropriate phenotype. Am J Phys Med Rehabil. 2009 Jun; 88(6):455-63. PMID: 19454853.
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    41. Sicot FX, Tsuda T, Markova D, Klement JF, Arita M, Zhang RZ, Pan TC, Mecham RP, Birk DE, Chu ML. Fibulin-2 is dispensable for mouse development and elastic fiber formation. Mol Cell Biol. 2008 Feb; 28(3):1061-7. PMID: 18070922.
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    42. Dasouki M, Markova D, Garola R, Sasaki T, Charbonneau NL, Sakai LY, Chu ML. Compound heterozygous mutations in fibulin-4 causing neonatal lethal pulmonary artery occlusion, aortic aneurysm, arachnodactyly, and mild cutis laxa. Am J Med Genet A. 2007 Nov 15; 143A(22):2635-41. PMID: 17937443.
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    43. Kobayashi N, Kostka G, Garbe JH, Keene DR, Bächinger HP, Hanisch FG, Markova D, Tsuda T, Timpl R, Chu ML, Sasaki T. A comparative analysis of the fibulin protein family. Biochemical characterization, binding interactions, and tissue localization. J Biol Chem. 2007 Apr 20; 282(16):11805-16. PMID: 17324935.
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    44. Tsuda T, Markova D, Wang H, Evangelisti L, Pan TC, Chu ML. Zinc finger protein Zac1 is expressed in chondrogenic sites of the mouse. Dev Dyn. 2004 Feb; 229(2):340-8. PMID: 14745959.
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    45. Tsuda T, Gao E, Evangelisti L, Markova D, Ma X, Chu ML. Post-ischemic myocardial fibrosis occurs independent of hemodynamic changes. Cardiovasc Res. 2003 Oct 1; 59(4):926-33. PMID: 14553832.
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    46. Markova D, Zou Y, Ringpfeil F, Sasaki T, Kostka G, Timpl R, Uitto J, Chu ML. Genetic heterogeneity of cutis laxa: a heterozygous tandem duplication within the fibulin-5 (FBLN5) gene. Am J Hum Genet. 2003 Apr; 72(4):998-1004. PMID: 12618961.
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