Erin Seifert

TitleAssoc Professor
InstitutionThomas Jefferson University
DepartmentPathology
Address1020 Locust St.
Philadelphia PA 19107
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    1. Han A, Purwin TJ, Bechtel N, Liao C, Chua V, Seifert E, Sato T, Schug ZT, Speicher DW, Harbour JW, Aplin AE. Correction to: BAP1 mutant uveal melanoma is stratified by metabolic phenotypes with distinct vulnerability to metabolic inhibitors. Oncogene. 2021 Mar; 40(9):1753. PMID: 33510355.
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    2. Han A, Purwin TJ, Bechtel N, Liao C, Chua V, Seifert E, Sato T, Schug ZT, Speicher DW, William Harbour J, Aplin AE. BAP1 mutant uveal melanoma is stratified by metabolic phenotypes with distinct vulnerability to metabolic inhibitors. Oncogene. 2020 Nov 18. PMID: 33208912.
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    3. Varner EL, Trefely S, Bartee D, von Krusenstiern E, Izzo L, Bekeova C, O'Connor RS, Seifert EL, Wellen KE, Meier JL, Snyder NW. Quantification of lactoyl-CoA (lactyl-CoA) by liquid chromatography mass spectrometry in mammalian cells and tissues. Open Biol. 2020 09; 10(9):200187. PMID: 32961073.
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    4. Bekeova C, Anderson-Pullinger L, Boye K, Boos F, Sharpadskaya Y, Herrmann JM, Seifert EL. Multiple mitochondrial thioesterases have distinct tissue and substrate specificity, and CoA regulation, suggesting unique functional roles. J Biol Chem. 2019 Nov 01. PMID: 31676684.
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    5. Debattisti V, Horn A, Singh R, Seifert EL, Hogarth MW, Mazala DA, Huang KT, Horvath R, Jaiswal JK, Hajnóczky G. Dysregulation of Mitochondrial Ca2+ Uptake and Sarcolemma Repair Underlie Muscle Weakness and Wasting in Patients and Mice Lacking MICU1. Cell Rep. 2019 Oct 29; 29(5):1274-1286.e6. PMID: 31665639.
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    6. He J, Liu W, Ge X, Wang GC, Desai V, Wang S, Mu W, Bhardwaj V, Seifert E, Liu LZ, Bhushan A, Peiper SC, Jiang BH. Arsenic-induced metabolic shift triggered by the loss of miR-199a-5p through Sp1-dependent DNA methylation. Toxicol Appl Pharmacol. 2019 Sep 01; 378:114606. PMID: 31170415.
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    7. Zhi L, Qin Q, Muqeem T, Seifert EL, Liu W, Zheng S, Li C, Zhang H. Loss of PINK1 causes age-dependent decrease of dopamine release and mitochondrial dysfunction. Neurobiol Aging. 2019 Mar; 75:1-10. PMID: 30504091.
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    8. Gubbiotti MA, Seifert E, Rodeck U, Hoek JB, Iozzo RV. Metabolic reprogramming of murine cardiomyocytes during autophagy requires the extracellular nutrient sensor decorin. J Biol Chem. 2018 Oct 26; 293(43):16940-16950. PMID: 30049794.
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    9. Silagi ES, Schoepflin ZR, Seifert EL, Merceron C, Schipani E, Shapiro IM, Risbud MV. Bicarbonate Recycling by HIF-1-Dependent Carbonic Anhydrase Isoforms 9 and 12 Is Critical in Maintaining Intracellular pH and Viability of Nucleus Pulposus Cells. J Bone Miner Res. 2018 Feb; 33(2):338-355. PMID: 28940640.
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    10. Gal A, Balicza P, Weaver D, Naghdi S, Joseph SK, Várnai P, Gyuris T, Horváth A, Nagy L, Seifert EL, Molnar MJ, Hajnóczky G. MSTO1 is a cytoplasmic pro-mitochondrial fusion protein, whose mutation induces myopathy and ataxia in humans. EMBO Mol Med. 2017 Jul; 9(7):967-984. PMID: 28554942.
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    11. Zarei M, Lal S, Parker SJ, Nevler A, Vaziri-Gohar A, Dukleska K, Mambelli-Lisboa NC, Moffat C, Blanco FF, Chand SN, Jimbo M, Cozzitorto JA, Jiang W, Yeo CJ, Londin E, Seifert EL, Metallo CM, Brody JR, Winter JM. Posttranscriptional upregulation of IDH1 by HuR establishes a powerful survival phenotype in pancreatic cancer cells. Cancer Res. 2017 Jun 26. PMID: 28652247.
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    12. Casimiro MC, Di Sante G, Di Rocco A, Loro E, Pupo C, Pestell TG, Bisetto S, Velasco-Velázquez MA, Jiao X, Li Z, Kusminski CM, Seifert EL, Wang C, Ly D, Zheng B, Shen CH, Scherer PE, Pestell RG. Cyclin D1 Restrains Oncogene-Induced Autophagy by Regulating the AMPK-LKB1 Signaling Axis. Cancer Res. 2017 Jul 01; 77(13):3391-3405. PMID: 28522753.
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    13. Paillard M, Csordás G, Szanda G, Golenár T, Debattisti V, Bartok A, Wang N, Moffat C, Seifert EL, Spät A, Hajnóczky G. Tissue-Specific Mitochondrial Decoding of Cytoplasmic Ca2+ Signals Is Controlled by the Stoichiometry of MICU1/2 and MCU. Cell Rep. 2017 Mar 07; 18(10):2291-2300. PMID: 28273446.
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    14. Ko YH, Domingo-Vidal M, Roche M, Lin Z, Whitaker-Menezes D, Seifert E, Capparelli C, Tuluc M, Birbe RC, Tassone P, Curry JM, Navarro-Sabate A, Manzano A, Bartrons R, Caro J, Martinez-Outschoorn U. TIGAR Metabolically Reprograms Carcinoma and Stromal Cells in Breast Cancer. J Biol Chem. 2016 Nov 1. PMID: 27803158.
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    15. Seifert EL, Gál A, Acoba MG, Li Q, Anderson-Pullinger L, Golenár T, Moffat C, Sondheimer N, Claypool SM, Hajnóczky G. Natural and induced mitochondrial phosphate carrier loss: differential dependence of mitochondrial metabolism and dynamics, and cell survival, on the extent of depletion. J Biol Chem. 2016 Oct 25. PMID: 27780865.
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    16. Choi H, Merceron C, Mangiavini L, Seifert EL, Schipani E, Shapiro IM, Risbud MV. Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling. Autophagy. 2016 Sep; 12(9):1631-46. PMID: 27314664.
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    17. Antony AN, Paillard M, Moffat C, Juskeviciute E, Correnti J, Bolon B, Rubin E, Csordás G, Seifert EL, Hoek JB, Hajnóczky G. MICU1 regulation of mitochondrial Ca(2+) uptake dictates survival and tissue regeneration. Nat Commun. 2016; 7:10955. PMID: 26956930.
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    18. Picard M, McManus MJ, Gray JD, Nasca C, Moffat C, Kopinski PK, Seifert EL, McEwen BS, Wallace DC. Mitochondrial functions modulate neuroendocrine, metabolic, inflammatory, and transcriptional responses to acute psychological stress. Proc Natl Acad Sci U S A. 2015 Dec 1; 112(48):E6614-23. PMID: 26627253.
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    19. Loro E, Seifert EL, Moffat C, Romero F, Mishra MK, Sun Z, Krajacic P, Anokye-Danso F, Summer RS, Ahima RS, Khurana TS. IL-15Ra is a determinant of muscle fuel utilization, and its loss protects against obesity. Am J Physiol Regul Integr Comp Physiol. 2015 Oct 15; 309(8):R835-44. PMID: 26269523.
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    20. Seifert EL, Ligeti E, Mayr JA, Sondheimer N, Hajnóczky G. The mitochondrial phosphate carrier: Role in oxidative metabolism, calcium handling and mitochondrial disease. Biochem Biophys Res Commun. 2015 Aug 21; 464(2):369-75. PMID: 26091567.
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    21. Fried NT, Moffat C, Seifert EL, Oshinsky ML. Functional mitochondrial analysis in acute brain sections from adult rats reveals mitochondrial dysfunction in a rat model of migraine. Am J Physiol Cell Physiol. 2014 Dec 1; 307(11):C1017-30. PMID: 25252946.
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    22. Thrush AB, Zhang R, Chen W, Seifert EL, Quizi JK, McPherson R, Dent R, Harper ME. Lower mitochondrial proton leak and decreased glutathione redox in primary muscle cells of obese diet-resistant versus diet-sensitive humans. J Clin Endocrinol Metab. 2014 Nov; 99(11):4223-30. PMID: 25148230.
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    23. Moffat C, Bhatia L, Nguyen T, Lynch P, Wang M, Wang D, Ilkayeva OR, Han X, Hirschey MD, Claypool SM, Seifert EL. Acyl-CoA thioesterase-2 facilitates mitochondrial fatty acid oxidation in the liver. J Lipid Res. 2014 Dec; 55(12):2458-70. PMID: 25114170.
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    24. Adijanto J, Du J, Moffat C, Seifert EL, Hurle JB, Philp NJ. The retinal pigment epithelium utilizes fatty acids for ketogenesis. J Biol Chem. 2014 Jul 25; 289(30):20570-82. PMID: 24898254.
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    25. Hajnóczky G, Booth D, Csordás G, Debattisti V, Golenár T, Naghdi S, Niknejad N, Paillard M, Seifert EL, Weaver D. Reliance of ER-mitochondrial calcium signaling on mitochondrial EF-hand Ca2+ binding proteins: Miros, MICUs, LETM1 and solute carriers. Curr Opin Cell Biol. 2014 Aug; 29:133-41. PMID: 24999559.
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    26. Caron AZ, He X, Mottawea W, Seifert EL, Jardine K, Dewar-Darch D, Cron GO, Harper ME, Stintzi A, McBurney MW. The SIRT1 deacetylase protects mice against the symptoms of metabolic syndrome. FASEB J. 2014 Mar; 28(3):1306-16. PMID: 24297700.
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    27. Aguer C, Fiehn O, Seifert EL, Bézaire V, Meissen JK, Daniels A, Scott K, Renaud JM, Padilla M, Bickel DR, Dysart M, Adams SH, Harper ME. Muscle uncoupling protein 3 overexpression mimics endurance training and reduces circulating biomarkers of incomplete ß-oxidation. FASEB J. 2013 Oct; 27(10):4213-25. PMID: 23825224.
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    28. Csordás G, Golenár T, Seifert EL, Kamer KJ, Sancak Y, Perocchi F, Moffat C, Weaver D, Perez Sde L, Bogorad R, Koteliansky V, Adijanto J, Mootha VK, Hajnóczky G. MICU1 Controls Both the Threshold and Cooperative Activation of the Mitochondrial Ca(2+) Uniporter. Cell Metab. 2013 Jun 4; 17(6):976-87. PMID: 23747253.
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    29. Seifert EL, Bastianelli M, Aguer C, Moffat C, Estey C, Koch LG, Britton SL, Harper ME. Intrinsic aerobic capacity correlates with greater inherent mitochondrial oxidative and H2O2 emission capacities without major shifts in myosin heavy chain isoform. J Appl Physiol. 2012 Nov; 113(10):1624-34. PMID: 22995392.
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    30. Estey C, Seifert EL, Aguer C, Moffat C, Harper ME. Calorie restriction in mice overexpressing UCP3: evidence that prior mitochondrial uncoupling alters response. Exp Gerontol. 2012 May; 47(5):361-71. PMID: 22406134.
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    31. Seifert EL, Caron AZ, Morin K, Coulombe J, He XH, Jardine K, Dewar-Darch D, Boekelheide K, Harper ME, McBurney MW. SirT1 catalytic activity is required for male fertility and metabolic homeostasis in mice. FASEB J. 2012 Feb; 26(2):555-66. PMID: 22006156.
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    32. Mailloux RJ, Seifert EL, Bouillaud F, Aguer C, Collins S, Harper ME. Glutathionylation acts as a control switch for uncoupling proteins UCP2 and UCP3. J Biol Chem. 2011 Jun 17; 286(24):21865-75. PMID: 21515686.
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    33. Lidell ME, Seifert EL, Westergren R, Heglind M, Gowing A, Sukonina V, Arani Z, Itkonen P, Wallin S, Westberg F, Fernandez-Rodriguez J, Laakso M, Nilsson T, Peng XR, Harper ME, Enerbäck S. The adipocyte-expressed forkhead transcription factor Foxc2 regulates metabolism through altered mitochondrial function. Diabetes. 2011 Feb; 60(2):427-35. PMID: 21270254.
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    34. Seifert EL, Fiehn O, Bezaire V, Bickel DR, Wohlgemuth G, Adams SH, Harper ME. Long-chain fatty acid combustion rate is associated with unique metabolite profiles in skeletal muscle mitochondria. PLoS One. 2010; 5(3):e9834. PMID: 20352092.
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    35. Gerrits MF, Ghosh S, Kavaslar N, Hill B, Tour A, Seifert EL, Beauchamp B, Gorman S, Stuart J, Dent R, McPherson R, Harper ME. Distinct skeletal muscle fiber characteristics and gene expression in diet-sensitive versus diet-resistant obesity. J Lipid Res. 2010 Aug; 51(8):2394-404. PMID: 20332421.
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    36. Bevilacqua L, Seifert EL, Estey C, Gerrits MF, Harper ME. Absence of uncoupling protein-3 leads to greater activation of an adenine nucleotide translocase-mediated proton conductance in skeletal muscle mitochondria from calorie restricted mice. Biochim Biophys Acta. 2010 Aug; 1797(8):1389-97. PMID: 20206124.
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    37. Seifert EL, Estey C, Xuan JY, Harper ME. Electron transport chain-dependent and -independent mechanisms of mitochondrial H2O2 emission during long-chain fatty acid oxidation. J Biol Chem. 2010 Feb 19; 285(8):5748-58. PMID: 20032466.
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    38. Schock SC, Xu J, Duquette PM, Qin Z, Lewandowski AJ, Rai PS, Thompson CS, Seifert EL, Harper ME, Chen HH. Rescue of neurons from ischemic injury by peroxisome proliferator-activated receptor-gamma requires a novel essential cofactor LMO4. J Neurosci. 2008 Nov 19; 28(47):12433-44. PMID: 19020036.
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    39. Seifert EL, Bézaire V, Estey C, Harper ME. Essential role for uncoupling protein-3 in mitochondrial adaptation to fasting but not in fatty acid oxidation or fatty acid anion export. J Biol Chem. 2008 Sep 12; 283(37):25124-31. PMID: 18628202.
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    40. Mandu-Hrit M, Seifert E, Kotsiopriftis M, Lauzier D, Haque T, Rohlicek C, Tabrizian M, Hamdy RC. OP-1 injection increases VEGF expression but not angiogenesis in a rabbit model of distraction osteogenesis. Growth Factors. 2008 Jun; 26(3):143-51. PMID: 18569022.
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    41. Boily G, Seifert EL, Bevilacqua L, He XH, Sabourin G, Estey C, Moffat C, Crawford S, Saliba S, Jardine K, Xuan J, Evans M, Harper ME, McBurney MW. SirT1 regulates energy metabolism and response to caloric restriction in mice. PLoS One. 2008; 3(3):e1759. PMID: 18335035.
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    42. Harper ME, Seifert EL. Thyroid hormone effects on mitochondrial energetics. Thyroid. 2008 Feb; 18(2):145-56. PMID: 18279015.
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    43. Costford SR, Seifert EL, Bézaire V, F Gerrits M, Bevilacqua L, Gowing A, Harper ME. The energetic implications of uncoupling protein-3 in skeletal muscle. Appl Physiol Nutr Metab. 2007 Oct; 32(5):884-94. PMID: 18059613.
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    44. Bézaire V, Seifert EL, Harper ME. Uncoupling protein-3: clues in an ongoing mitochondrial mystery. FASEB J. 2007 Feb; 21(2):312-24. PMID: 17202247.
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    45. Seifert EL, Sant Anna GM, Rohlicek CV. Effect of body warming on regional blood flow distribution in conscious hypoxic one-month-old rabbits. Biol Neonate. 2006; 90(2):104-12. PMID: 16549907.
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    46. Seifert EL, Mortola JP. Circadian pattern of ventilation during prolonged hypoxia in conscious rats. Respir Physiol Neurobiol. 2002 Oct 23; 133(1-2):23-34. PMID: 12385728.
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    47. Mortola JP, Seifert EL. Circadian patterns of breathing. Respir Physiol Neurobiol. 2002 Jul; 131(1-2):91-100. PMID: 12106998.
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    48. Seifert EL, Mortola JP. Circadian pattern of ventilation during acute and chronic hypercapnia in conscious adult rats. Am J Physiol Regul Integr Comp Physiol. 2002 Jan; 282(1):R244-51. PMID: 11742844.
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    49. Seifert EL, Mortola JP. The circadian pattern of breathing in conscious adult rats. Respir Physiol. 2002 Jan; 129(3):297-305. PMID: 11788133.
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