Fred Gorstein

TitleEmeritus Faculty
InstitutionThomas Jefferson University
DepartmentPathology & Genomic Medicine
Address1020 Locust St.
Philadelphia PA 19107
Phone215-503-7602
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    Collapse Overview 
    Collapse overview
    1. Medical Education
    2. Gynecologic Pathology
    3. Health Care Policy
    4. Medical Publishing


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Bailey DN, Buja LM, Gorstein F, Gotlieb A, Green R, Kane A, Lipscomb MF, Sanfilippo F. Life After Being a Pathology Department Chair III: Reflections on the "Afterlife". Acad Pathol. 2019 Jan-Dec; 6:2374289519846068. PMID: 31069254.
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    2. Bailey DN, Lipscomb MF, Gorstein F, Wilkinson D, Sanfilippo F. Life After Being a Pathology Department Chair II: Lessons Learned. Acad Pathol. 2017 Jan-Dec; 4:2374289517733734. PMID: 29057316.
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    3. Bailey DN, Lipscomb MF, Gorstein F, Wilkinson D, Sanfilippo F. Life After Being a Pathology Department Chair: Issues and Opportunities. Acad Pathol. 2016 Jan-Dec; 3:2374289516673651. PMID: 28725780.
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    4. Silverberg SG, Bell DA, Kurman RJ, Seidman JD, Prat J, Ronnett BM, Copeland L, Silva E, Gorstein F, Young RH. Borderline ovarian tumors: key points and workshop summary. Hum Pathol. 2004 Aug; 35(8):910-7. PMID: 15297959.
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    5. Sherman ME, Berman J, Birrer MJ, Cho KR, Ellenson LH, Gorstein F, Seidman JD. Current challenges and opportunities for research on borderline ovarian tumors. Hum Pathol. 2004 Aug; 35(8):961-70. PMID: 15297963.
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    6. Gorstein F, Mostofi FK. Armed Forces Institute of Pathology in jeopardy--who should care? Hum Pathol. 2003 Mar; 34(3):203-5; discussion 205. PMID: 12673552.
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    7. Gorstein F. Professionalism in pathology. Hum Pathol. 2002 Aug; 33(8):777-8. PMID: 12203207.
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    8. Fletcher CD, Berman JJ, Corless C, Gorstein F, Lasota J, Longley BJ, Miettinen M, O'Leary TJ, Remotti H, Rubin BP, Shmookler B, Sobin LH, Weiss SW. Diagnosis of gastrointestinal stromal tumors: A consensus approach. Hum Pathol. 2002 May; 33(5):459-65. PMID: 12094370.
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    9. Fletcher CD, Berman JJ, Corless C, Gorstein F, Lasota J, Longley BJ, Miettinen M, O'Leary TJ, Remotti H, Rubin BP, Shmookler B, Sobin LH, Weiss SW. Diagnosis of gastrointestinal stromal tumors: a consensus approach. Int J Surg Pathol. 2002 Apr; 10(2):81-9. PMID: 12075401.
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    10. Gorstein F. Trends in pathology education. Hum Pathol. 2002 Jan; 33(1):2. PMID: 11823967.
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    11. McCue PA, Gorstein F. Genetic markers in renal cell carcinomas. Hum Pathol. 2001 Oct; 32(10):1027-8. PMID: 11679934.
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    12. Foster CS, Gorstein F. Molecular basis of disease processes. Hum Pathol. 2001 Jun; 32(6):567-8. PMID: 11431709.
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    13. Gorstein F, Weinstein RS. Rethinking pathology residency training and education. Hum Pathol. 2001 Jan; 32(1):1-3. PMID: 11172287.
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    14. Gorstein F. Precursor lesions of squamous cell carcinoma of the cervix: are there reliable predictors of biologic behavior? Hum Pathol. 2000 Nov; 31(11):1339-40. PMID: 11112206.
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    15. Bruner KL, Eisenberg E, Gorstein F, Osteen KG. Progesterone and transforming growth factor-beta coordinately regulate suppression of endometrial matrix metalloproteinases in a model of experimental endometriosis. Steroids. 1999 Sep; 64(9):648-53. PMID: 10503723.
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    16. Strayer DS, Foster CS, Gorstein F. Whither human pathology? Hum Pathol. 1999 Jan; 30(1):1-2. PMID: 9923918.
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    17. Bruner KL, Matrisian LM, Rodgers WH, Gorstein F, Osteen KG. Suppression of matrix metalloproteinases inhibits establishment of ectopic lesions by human endometrium in nude mice. J Clin Invest. 1997 Jun 15; 99(12):2851-7. PMID: 9185507.
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    18. Henson DE, Fielding LP, Grignon DJ, Page DL, Hammond ME, Nash G, Pettigrew NM, Gorstein F, Hutter RV. College of American Pathologists Conference XXVI on clinical relevance of prognostic markers in solid tumors. Summary. Members of the Cancer Committee. Arch Pathol Lab Med. 1995 Dec; 119(12):1109-12. PMID: 7503658.
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    19. Osteen KG, Rodgers WH, Gaire M, Hargrove JT, Gorstein F, Matrisian LM. Stromal-epithelial interaction mediates steroidal regulation of metalloproteinase expression in human endometrium. Proc Natl Acad Sci U S A. 1994 Oct 11; 91(21):10129-33. PMID: 7937850.
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    20. Rodgers WH, Matrisian LM, Giudice LC, Dsupin B, Cannon P, Svitek C, Gorstein F, Osteen KG. Patterns of matrix metalloproteinase expression in cycling endometrium imply differential functions and regulation by steroid hormones. J Clin Invest. 1994 Sep; 94(3):946-53. PMID: 8083380.
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    21. Gorstein F. Toward monoclonal antibody standardization. Hum Pathol. 1994 Jan; 25(1):1. PMID: 8314254.
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    22. Rodgers WH, Osteen KG, Matrisian LM, Navre M, Giudice LC, Gorstein F. Expression and localization of matrilysin, a matrix metalloproteinase, in human endometrium during the reproductive cycle. Am J Obstet Gynecol. 1993 Jan; 168(1 Pt 1):253-60. PMID: 8420336.
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    23. Page DL, Gorstein F. Heterogeneity of neoplasms: bother or promise? Hum Pathol. 1992 Aug; 23(8):845. PMID: 1644429.
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    24. Osteen KG, Anderson TL, Schwartz K, Hargrove JT, Gorstein F. Distribution of tumor-associated glycoprotein-72 (TAG-72) expression throughout the normal female reproductive tract. Int J Gynecol Pathol. 1992 Jul; 11(3):216-20. PMID: 1399229.
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    25. Gorstein F, Anderson TL. Malignant mixed mesodermal tumors: carcinoma, sarcoma, or both? Hum Pathol. 1991 Mar; 22(3):207-9. PMID: 1848525.
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    26. Page DL, Gorstein F. Diversity of malignant melanoma and its precursor lesions. Hum Pathol. 1990 Dec; 21(12):1195-6. PMID: 2249830.
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    27. Anderson RE, Hill RB, Gorstein F. A model for the autopsy-based quality assessment of medical diagnostics. Arch Pathol Lab Med. 1990 Nov; 114(11):1163. PMID: 2241528.
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    28. Osteen KG, Anderson TL, Hargrove JT, Hill GA, Gorstein F. Epithelial cells from normal human endometrium express a tumor-associated glycoprotein (TAG-72) epitope in vitro. Am J Obstet Gynecol. 1990 Aug; 163(2):479-84. PMID: 1696780.
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    29. Anderson TL, Gorstein F, Osteen KG. Stromal-epithelial cell communication, growth factors, and tissue regulation. Lab Invest. 1990 May; 62(5):519-21. PMID: 2188045.
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    30. Gorstein F. Pathologists' input to Harvard resource-based relative value scale survey: a major determinant in the accuracy of a Medicare physician fee schedule. Hum Pathol. 1990 Mar; 21(3):243-4. PMID: 2179108.
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    31. Anderson RE, Hill RB, Gorstein F. A model for the autopsy-based quality assessment of medical diagnostics. Hum Pathol. 1990 Feb; 21(2):174-81. PMID: 2307445.
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    32. Gorstein F, Trelstad R. The pathologist as student and educator. Hum Pathol. 1990 Jan; 21(1):1-3. PMID: 2295501.
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    33. Osteen KG, Hill GA, Hargrove JT, Gorstein F. Development of a method to isolate and culture highly purified populations of stromal and epithelial cells from human endometrial biopsy specimens. Fertil Steril. 1989 Dec; 52(6):965-72. PMID: 2687030.
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    34. Gorstein F. The dynamic extracellular matrix. Hum Pathol. 1988 Jul; 19(7):751-2. PMID: 3402969.
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    35. Gorstein F. The AIDS plague--the pathologist's responsibility. Hum Pathol. 1988 May; 19(5):499-500. PMID: 3371972.
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    36. Thor A, Muraro R, Gorstein F, Ohuchi N, Viglione M, Szpak CA, Johnston WW, Schlom J. Adjunct to the diagnostic distinction between adenocarcinomas of the ovary and the colon utilizing a monoclonal antibody (COL-4) with restricted carcinoembryonic antigen reactivity. Cancer Res. 1987 Jan 15; 47(2):505-12. PMID: 2431771.
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    37. Thor A, Viglione MJ, Muraro R, Ohuchi N, Schlom J, Gorstein F. Monoclonal antibody B72.3 reactivity with human endometrium: a study of normal and malignant tissues. Int J Gynecol Pathol. 1987; 6(3):235-47. PMID: 3429107.
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    38. Thor A, Gorstein F, Ohuchi N, Szpak CA, Johnston WW, Schlom J. Tumor-associated glycoprotein (TAG-72) in ovarian carcinomas defined by monoclonal antibody B72.3. J Natl Cancer Inst. 1986 Jun; 76(6):995-1006. PMID: 3520078.
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    39. Day CL, Mihm MC, Sober AJ, Harris MN, Kopf AW, Fitzpatrick TB, Lew RA, Harrist TJ, Golomb FM, Postel A, Hennessey P, Gumport SL, Raker JW, Malt RA, Cosimi AB, Wood WC, Roses DF, Gorstein F, Rigel D, Friedman RJ, Mintzis MM. Predictors of late deaths among patients with clinical stage I melanoma who have not had bony or visceral metastases within the first 5 years after diagnosis. J Am Acad Dermatol. 1983 Jun; 8(6):864-8. PMID: 6863649.
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    40. Day CL, Lew RA, Mihm MC, Sober AJ, Harris MN, Kopf AW, Fitzpatrick TB, Harrist TJ, Golomb FM, Postel A, Hennessey P, Gumport SL, Raker JW, Malt RA, Cosimi AB, Wood WC, Roses DF, Gorstein F, Rigel D, Friedman RJ, Mintzis MM, Grier RW. A multivariate analysis of prognostic factors for melanoma patients with lesions greater than or equal to 3.65 mm in thickness. The importance of revealing alternative Cox models. Ann Surg. 1982 Jan; 195(1):44-9. PMID: 7055383.
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    41. Day CL, Mihm MC, Sober AJ, Harris MN, Kopf AW, Fitzpatrick TB, Lew RA, Harrist TJ, Golomb FM, Postel A, Hennessey P, Gumport SL, Raker JW, Malt RA, Cosimi AB, Wood WC, Roses DF, Gorstein F, Rigel D, Friedman RJ, Mintzis MM. Prognostic factors for melanoma patients with lesions 0.76 - 1.69 mm in thickness. An appraisal of "thin" level IV lesions. Ann Surg. 1982 Jan; 195(1):30-4. PMID: 7055381.
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    42. Day CL, Mihm MC, Lew RA, Harris MN, Kopf AW, Fitzpatrick TB, Harrist TJ, Golomb FM, Postel A, Hennessey P, Gumport SL, Raker JW, Malt RA, Cosimi AB, Wood WC, Roses DF, Gorstein F, Rigel D, Friedman RJ, Mintzis MM, Sober AJ. Prognostic factors for patients with clinical stage I melanoma of intermediate thickness (1.51 - 3.39 mm). A conceptual model for tumor growth and metastasis. Ann Surg. 1982 Jan; 195(1):35-43. PMID: 7055382.
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    43. Day CL, Sober AJ, Kopf AW, Lew RA, Mihm MC, Golomb FM, Postel A, Hennessey P, Harris MN, Gumport SL, Raker JW, Malt RA, Cosimi AB, Wood WC, Roses DF, Gorstein F, Fitzpatrick TB. A prognostic model for clinical stage I melanoma of the trunk. Location near the midline is not an independent risk factor for recurrent disease. Am J Surg. 1981 Aug; 142(2):247-51. PMID: 7258536.
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    44. Day CL, Harrist TJ, Gorstein F, Sober AJ, Lew RA, Friedman RJ, Pasternack BS, Kopf AW, Fitzpatrick TB, Mihm MC. Malignant melanoma. Prognostic significance of "microscopic satellites" in the reticular dermis and subcutaneous fat. Ann Surg. 1981 Jul; 194(1):108-12. PMID: 7247529.
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    45. Day CL, Sober AJ, Kopf AW, Lew RA, Mihm MC, Golomb FM, Hennessey P, Harris MN, Gumport SL, Raker JW, Malt RA, Cosimi AB, Wood WC, Roses DF, Gorstein F, Fitzpatrick TB, Postel A. A prognostic model for clinical stage I melanoma of the lower extremity. Location on foot as independent risk factor for recurrent disease. Surgery. 1981 May; 89(5):599-603. PMID: 7221889.
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    46. Day CL, Sober AJ, Kopf AW, Lew RA, Mihm MC, Hennessey P, Golomb FM, Harris MN, Gumport SL, Raker JW, Malt RA, Cosimi AB, Wood WC, Roses DF, Gorstein F, Postel A, Grier WR, Mintzis MN, Fitzpatrick TB. A prognostic model for clinical stage I melanoma of the upper extremity. The importance of anatomic subsites in predicting recurrent disease. Ann Surg. 1981 Apr; 193(4):436-40. PMID: 7212806.
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    47. Day CL, Sober AJ, Lew RA, Mihm MC, Fitzpatrick TB, Kopf AW, Harris MN, Gumport SL, Raker JW, Malt RA, Golomb FM, Cosimi AB, Wood WC, Casson P, Lopransi S, Gorstein F, Postel A. Malignant melanoma patients with positive nodes and relatively good prognoses: microstaging retains prognostic significance in clinical stage I melanoma patients with metastases to regional nodes. Cancer. 1981 Mar 01; 47(5):955-62. PMID: 7226047.
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    48. Roses DF, Harris MN, Gorstein F, Gumport SL. Biopsy for microcalcification detected by mammography. Surgery. 1980 Mar; 87(3):248-52. PMID: 6244682.
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    49. Edwards JH, Kricheff II, Gorstein F, Riles T, Imparato A. Atherosclerotic subintimal hematoma of the carotid artery. Radiology. 1979 Oct; 133(1):123-9. PMID: 472280.
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    50. Imparato AM, Riles TS, Gorstein F. The carotid bifurcation plaque: pathologic findings associated with cerebral ischemia. Stroke. 1979 May-Jun; 10(3):238-45. PMID: 462508.
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    51. Chalon J, Tang CK, Gorstein F, Turndorf H, Katz JS, Klein GS, Patel C. Diagnostic and prognostic significance of tracheobronchial epithelial multinucleation. Acta Cytol. 1978 Sep-Oct; 22(5):316-20. PMID: 281837.
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    52. Culliford AT, Isom OW, Trehan NK, Doyle E, Gorstein F, Spencer FC. Benign tumors of right atrium necessitating extensive resection and reconstruction. J Thorac Cardiovasc Surg. 1978 Aug; 76(2):178-82. PMID: 682650.
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    53. Friedman-Mor Z, Chalon J, Gorstein F, Turndorf H, Chuba JV, Orkin LR. Abnormal heme-protein patterns in hemorrhagic shock. J Trauma. 1978 Feb; 18(2):104-7. PMID: 633416.
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    54. Dancis J, Jansen V, Brown GF, Gorstein F, Balis ME. Treatment of hypoplastic anemia in mice with placental transplants. Blood. 1977 Oct; 50(4):663-70. PMID: 901940.
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    55. Weiss G, Shenker L, Gorstein F. Suppurating myoma with spontaneous drainage through abdominal wall. N Y State J Med. 1976 Apr; 76(4):572-3. PMID: 131260.
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    56. Chalon J, Katz JS, Gorstein F, Turndorf H. Malignant disease and tracheobronchial epithelial multinucleation. Cancer. 1976 Apr; 37(4):1874-81. PMID: 769941.
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    57. Freidman-Mor Z, Chalon J, Katz JS, Gorstein F, Turndorf H, Orkin LR. Tracheobronchial and pulmonary cytologic changes in shock. J Trauma. 1976 Jan; 16(1):58-62. PMID: 54439.
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    58. Weiss G, Weick RF, Knobil E, Wolman SR, Gorstein F. An X-O anomaly and ovarian dysgenesis in a rhesus monkey. Folia Primatol (Basel). 1973; 19(1):24-7. PMID: 4198054.
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    59. Gelfand ML, Kantor T, Gorstein F. Cogan's syndrome with cardiovascular involvement: aortic insufficiency. Bull N Y Acad Med. 1972 May; 48(4):647-60. PMID: 4503925.
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    60. Winkelman J, Gorstein F. Quantitative studies on the accumulation of tetracycline in tumors. Experientia. 1971 Mar 15; 27(3):309-10. PMID: 4993735.
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    61. Lehfeldt H, Tietze C, Gorstein F. Ovarian pregnancy and the intrauterine device. Am J Obstet Gynecol. 1970 Dec 01; 108(7):1005-9. PMID: 5479680.
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    62. Dumont AE, Pugkhem T, Grosfeld J, Gorstein F. Alterations in splenic hilar lymphatics in patients with congestion of the spleen. Proc Soc Exp Biol Med. 1970 Dec; 135(3):642-7. PMID: 5486697.
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    63. Katz J, Levitz M, Gorstein F, Troll W. Influence of trypsin on in vitro RNA synthesis by disrupted nuclei of rat and human uteri in different hormonal states. Endocrinology. 1970 Aug; 87(2):294-301. PMID: 5424998.
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    64. Beller FK, Graeff H, Gorstein F. Disseminated intravascular coagulation during the continuous infusion of endotoxin in rabbits. Morphologic and physiologic studies. Am J Obstet Gynecol. 1969 Feb 15; 103(4):544-54. PMID: 4884783.
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    65. Mufson MA, Kawana R, Bloom HH, Gorstein F, Chanock RM. Pathogenicity of Coxsackie A-21 virus for suckling mice. Proc Soc Exp Biol Med. 1968 May; 128(1):237-46. PMID: 5656698.
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    66. Dancis J, Jansen V, Gorstein F, Douglas GW. Hematopoietic cells in mouse placenta. Am J Obstet Gynecol. 1968 Apr 15; 100(8):1110-21. PMID: 5643190.
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    67. Young BK, Gorstein F. Maternal osteogenesis imperfecta. Obstet Gynecol. 1968 Apr; 31(4):461-70. PMID: 5300442.
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    68. Gorstein F, Carroll HJ, Puszkin E. Electrolyte concentrations, potassium flux kinetics, and the metabolic dependence of potassium transport in human platelets. J Lab Clin Med. 1967 Dec; 70(6):938-50. PMID: 6059405.
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    69. Beller FK, Mitchell PS, Gorstein F. Fibrin deposition in the ribbit kidney produced by protease inhibitors. Thromb Diath Haemorrh. 1967 May 31; 17(3-4):427-39. PMID: 5301528.
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    70. Phillips BP, Gorstein F. Effects of different species of bacteria on the pathology of enteric amebiasis in monocontaminated guinea pigs. Am J Trop Med Hyg. 1966 Nov; 15(6):863-8. PMID: 4289542.
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    71. GORSTEIN F, PAN C, SHINOWARA GS, MIESCHER PA. Studies of platelet specific antigens by means of heterospecific antisera. Vox Sang. 1961 Nov; 6:669-82. PMID: 13900614.
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    72. MIESCHER P, GORSTEIN F, BENACERRAF B, GELL PG. Studies on the pathogenesis of experimental immune thyroiditis. Proc Soc Exp Biol Med. 1961 May; 107:12-6. PMID: 13770414.
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    73. GORSTEIN F, BENACERRAF B. Hyperactivity of the reticuloendothelial system and experimental anemia in mice. Am J Pathol. 1960 Nov; 37:569-82. PMID: 13707331.
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