Thomas Jefferson University

Gabriela Brailoiu

TitleAssoc Prof CHP
InstitutionThomas Jefferson University
DepartmentJSP - Pharmaceutical Science
Address901 Walnut Street
Philadelphia PA 19107
Phone215-503-7468
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    R03NS099957     (BRAILOIU, GABRIELA CRISTINA)May 15, 2018 - Apr 30, 2021
    NIH
    Modulation of the Blood-Brain Barrier by Novel Cannabinoid Receptors
    Role: Principal Investigator
    R01DA054921     (UNTERWALD, ELLEN M)Jul 1, 2022 - Apr 30, 2027
    NIH
    SARS-CoV-2 signaling and interactions with stimulant drugs of abuse via Sigma-1R: Impact on the BBB
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Brailoiu E, Barr JL, Wittorf HN, Inan S, Unterwald EM, Brailoiu GC. Modulation of the Blood-Brain Barrier by Sigma-1R Activation. Int J Mol Sci. 2024 May 09; 25(10). PMID: 38791182.
      Citations:    
    2. Yuan Y, Arige V, Saito R, Mu Q, Brailoiu GC, Pereira GJS, Bolsover SR, Keller M, Bracher F, Grimm C, Brailoiu E, Marchant JS, Yule DI, Patel S. Two-pore channel-2 and inositol trisphosphate receptors coordinate Ca2+ signals between lysosomes and the endoplasmic reticulum. Cell Rep. 2023 Dec 30; 43(1):113628. PMID: 38160394.
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    3. Lindenau KL, Barr JL, Higgins CR, Sporici KT, Brailoiu E, Brailoiu GC. Blood-Brain Barrier Disruption Mediated by FFA1 Receptor-Evidence Using Miniscope. Int J Mol Sci. 2022 Feb 18; 23(4). PMID: 35216375.
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    4. Brailoiu E, Deliu E, Sporici RA, Brailoiu GC. Irisin evokes bradycardia by activating cardiac-projecting neurons of nucleus ambiguus. Physiol Rep. 2015 Jun; 3(6). PMID: 26038469.
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    5. Deliu E, Sperow M, Console-Bram L, Carter RL, Tilley DG, Kalamarides DJ, Kirby LG, Brailoiu GC, Brailoiu E, Benamar K, Abood ME. The Lysophosphatidylinositol Receptor GPR55 Modulates Pain Perception in the Periaqueduactal Grey. Mol Pharmacol. 2015 May 13. PMID: 25972448.
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    6. Altmann JB, Yan G, Meeks JF, Abood ME, Brailoiu E, Brailoiu GC. G protein-coupled estrogen receptor-mediated effects on cytosolic calcium and nanomechanics in brain microvascular endothelial cells. J Neurochem. 2015 Jun; 133(5):629-39. PMID: 25703621.
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    7. Hockey LN, Kilpatrick BS, Eden ER, Lin-Moshier Y, Brailoiu GC, Brailoiu E, Futter CE, Schapira AH, Marchant JS, Patel S. Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibition. J Cell Sci. 2015 Jan 15; 128(2):232-8. PMID: 25416817.
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    8. Rahman T, Cai X, Brailoiu GC, Abood ME, Brailoiu E, Patel S. Two-pore channels provide insight into the evolution of voltage-gated Ca2+ and Na+ channels. Sci Signal. 2014 Nov 18; 7(352):ra109. PMID: 25406377.
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    9. Console-Bram L, Brailoiu E, Brailoiu GC, Sharir H, Abood ME. Activation of GPR18 by cannabinoid compounds: a tale of biased agonism. Br J Pharmacol. 2014 Aug; 171(16):3908-17. PMID: 24762058.
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    10. Brailoiu GC, Deliu E, Marcu J, Hoffman NE, Console-Bram L, Zhao P, Madesh M, Abood ME, Brailoiu E. Differential Activation of Intracellular versus Plasmalemmal CB2 Cannabinoid Receptors. Biochemistry. 2014 Aug 5; 53(30):4990-9. PMID: 25033246.
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    11. Brailoiu GC, Deliu E, Altmann JB, Chitravanshi V, Brailoiu E. Evidence for role of acid-sensing ion channels in nucleus ambiguus neurons: essential differences in anesthetized versus awake rats. J Comp Physiol B. 2014 Aug; 184(6):753-61. PMID: 24752669.
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    12. Brailoiu E, Deliu E, Sporici RA, Benamar K, Brailoiu GC. HIV-1-Tat excites cardiac parasympathetic neurons of nucleus ambiguus and triggers prolonged bradycardia in conscious rats. Am J Physiol Regul Integr Comp Physiol. 2014 Jun 1; 306(11):R814-22. PMID: 24694382.
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    13. Brailoiu GC, Deliu E, Rabinowitz JE, Tilley DG, Koch WJ, Brailoiu E. Urotensin II promotes vagal-mediated bradycardia by activating cardiac-projecting parasympathetic neurons of nucleus ambiguus. J Neurochem. 2014 May; 129(4):628-36. PMID: 24521102.
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    14. Deliu E, Brailoiu GC, Eguchi S, Hoffman NE, Rabinowitz JE, Tilley DG, Madesh M, Koch WJ, Brailoiu E. Direct evidence of intracrine angiotensin II signaling in neurons. Am J Physiol Cell Physiol. 2014 Apr; 306(8):C736-44. PMID: 24401846.
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    15. Brailoiu GC, Benamar K, Arterburn JB, Gao E, Rabinowitz JE, Koch WJ, Brailoiu E. Aldosterone increases cardiac vagal tone via G protein-coupled oestrogen receptor activation. J Physiol. 2013 Sep 1; 591(Pt 17):4223-35. PMID: 23878371.
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    16. Brailoiu GC, Deliu E, Tica AA, Rabinowitz JE, Tilley DG, Benamar K, Koch WJ, Brailoiu E. Nesfatin-1 activates cardiac vagal neurons of nucleus ambiguus and elicits bradycardia in conscious rats. J Neurochem. 2013 Sep; 126(6):739-48. PMID: 23795642.
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    17. Yu J, Deliu E, Zhang XQ, Hoffman NE, Carter RL, Grisanti LA, Brailoiu GC, Madesh M, Cheung JY, Force T, Abood ME, Koch WJ, Tilley DG, Brailoiu E. Differential activation of cultured neonatal cardiomyocytes by plasmalemmal versus intracellular G protein-coupled receptor 55. J Biol Chem. 2013 Aug 2; 288(31):22481-92. PMID: 23814062.
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    18. Aley PK, Singh N, Brailoiu GC, Brailoiu E, Churchill GC. Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger in muscarinic receptor-induced contraction of guinea pig trachea. J Biol Chem. 2013 Apr 19; 288(16):10986-93. PMID: 23467410.
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    19. Brailoiu GC, Arterburn JB, Oprea TI, Chitravanshi VC, Brailoiu E. Bradycardic effects mediated by activation of G protein-coupled estrogen receptor in rat nucleus ambiguus. Exp Physiol. 2013 Mar; 98(3):679-91. PMID: 23104934.
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    20. Deliu E, Brailoiu GC, Mallilankaraman K, Wang H, Madesh M, Undieh AS, Koch WJ, Brailoiu E. Intracellular Endothelin Type B Receptor-driven Ca2+ Signal Elicits Nitric Oxide Production in Endothelial Cells. J Biol Chem. 2012 Nov 30; 287(49):41023-31. PMID: 23086942.
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    21. Brailoiu GC, Deliu E, Tica AA, Chitravanshi VC, Brailoiu E. Urocortin 3 elevates cytosolic calcium in nucleus ambiguus neurons. J Neurochem. 2012 Sep; 122(6):1129-36. PMID: 22774996.
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    22. Deliu E, Brailoiu GC, Arterburn JB, Oprea TI, Benamar K, Dun NJ, Brailoiu E. Mechanisms of G protein-coupled estrogen receptor-mediated spinal nociception. J Pain. 2012 Aug; 13(8):742-54. PMID: 22858342.
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    23. Brailoiu GC, Deliu E, Hooper R, Dun NJ, Undieh AS, Adler MW, Benamar K, Brailoiu E. Agonist-selective effects of opioid receptor ligands on cytosolic calcium concentration in rat striatal neurons. Drug Alcohol Depend. 2012 Jun 1; 123(1-3):277-81. PMID: 22196236.
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    24. Tica AA, Dun EC, Tica OS, Gao X, Arterburn JB, Brailoiu GC, Oprea TI, Brailoiu E. G protein-coupled estrogen receptor 1-mediated effects in the rat myometrium. Am J Physiol Cell Physiol. 2011 Nov; 301(5):C1262-9. PMID: 21865584.
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    25. Brailoiu GC, Oprea TI, Zhao P, Abood ME, Brailoiu E. Intracellular cannabinoid type 1 (CB1) receptors are activated by anandamide. J Biol Chem. 2011 Aug 19; 286(33):29166-74. PMID: 21719698.
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    26. Deliu E, Tica AA, Motoc D, Brailoiu GC, Brailoiu E. Intracellular angiotensin II activates rat myometrium. Am J Physiol Cell Physiol. 2011 Sep; 301(3):C559-65. PMID: 21613610.
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    27. Brailoiu E, Rahman T, Churamani D, Prole DL, Brailoiu GC, Hooper R, Taylor CW, Patel S. An NAADP-gated two-pore channel targeted to the plasma membrane uncouples triggering from amplifying Ca2+ signals. J Biol Chem. 2010 Dec 3; 285(49):38511-6. PMID: 20880839.
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    28. Brailoiu GC, Gurzu B, Gao X, Parkesh R, Aley PK, Trifa DI, Galione A, Dun NJ, Madesh M, Patel S, Churchill GC, Brailoiu E. Acidic NAADP-sensitive calcium stores in the endothelium: agonist-specific recruitment and role in regulating blood pressure. J Biol Chem. 2010 Nov 26; 285(48):37133-7. PMID: 20876534.
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    29. Dun SL, Brailoiu GC, Tica AA, Yang J, Chang JK, Brailoiu E, Dun NJ. Neuronostatin is co-expressed with somatostatin and mobilizes calcium in cultured rat hypothalamic neurons. Neuroscience. 2010 Mar 17; 166(2):455-63. PMID: 20056135.
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    30. Trecki J, Brailoiu GC, Unterwald EM. Localization of CXCR4 in the forebrain of the adult rat. Brain Res. 2010 Feb 22; 1315:53-62. PMID: 20026091.
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    31. Brailoiu E, Hooper R, Cai X, Brailoiu GC, Keebler MV, Dun NJ, Marchant JS, Patel S. An ancestral deuterostome family of two-pore channels mediates nicotinic acid adenine dinucleotide phosphate-dependent calcium release from acidic organelles. J Biol Chem. 2010 Jan 29; 285(5):2897-901. PMID: 19940116.
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    32. Brailoiu E, Churamani D, Cai X, Schrlau MG, Brailoiu GC, Gao X, Hooper R, Boulware MJ, Dun NJ, Marchant JS, Patel S. Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling. J Cell Biol. 2009 Jul 27; 186(2):201-9. PMID: 19620632.
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    33. Dun SL, Brailoiu GC, Gao X, Brailoiu E, Arterburn JB, Prossnitz ER, Oprea TI, Dun NJ. Expression of estrogen receptor GPR30 in the rat spinal cord and in autonomic and sensory ganglia. J Neurosci Res. 2009 May 15; 87(7):1610-9. PMID: 19125412.
      Citations:    
    34. Brailoiu GC, Brailoiu E, Parkesh R, Galione A, Churchill GC, Patel S, Dun NJ. NAADP-mediated channel 'chatter' in neurons of the rat medulla oblongata. Biochem J. 2009 Apr 1; 419(1):91-7, 2 p following 97. PMID: 19090786.
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    35. Brailoiu E, Dun SL, Gao X, Brailoiu GC, Li JG, Luo JJ, Yang J, Chang JK, Liu-Chen LY, Dun NJ. C-peptide of preproinsulin-like peptide 7: localization in the rat brain and activity in vitro. Neuroscience. 2009 Mar 17; 159(2):492-500. PMID: 19373968.
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    36. Haas E, Bhattacharya I, Brailoiu E, Damjanovic M, Brailoiu GC, Gao X, Mueller-Guerre L, Marjon NA, Gut A, Minotti R, Meyer MR, Amann K, Ammann E, Perez-Dominguez A, Genoni M, Clegg DJ, Dun NJ, Resta TC, Prossnitz ER, Barton M. Regulatory role of G protein-coupled estrogen receptor for vascular function and obesity. Circ Res. 2009 Feb 13; 104(3):288-91. PMID: 19179659.
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    37. Gao X, Brailoiu GC, Brailoiu E, Dun SL, Yang J, Chang JK, Dun NJ. Copeptin immunoreactivity and calcium mobilisation in hypothalamic neurones of the rat. J Neuroendocrinol. 2008 Nov; 20(11):1242-51. PMID: 18752653.
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    38. Brailoiu E, Jiang X, Brailoiu GC, Yang J, Chang JK, Wang H, Dun NJ. State-dependent calcium mobilization by urotensin-II in cultured human endothelial cells. Peptides. 2008 May; 29(5):721-6. PMID: 18314227.
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    39. Brailoiu GC, Brailoiu E, Chang JK, Dun NJ. Excitatory effects of human immunodeficiency virus 1 Tat on cultured rat cerebral cortical neurons. Neuroscience. 2008 Feb 6; 151(3):701-10. PMID: 18164555.
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    40. Brailoiu GC, Dun SL, Brailoiu E, Inan S, Yang J, Chang JK, Dun NJ. Nesfatin-1: distribution and interaction with a G protein-coupled receptor in the rat brain. Endocrinology. 2007 Oct; 148(10):5088-94. PMID: 17627999.
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    41. Brailoiu GC, Dun SL, Mizuo K, Brailoiu E, Yang J, Chang JK, Dun NJ. Smooth muscle-associated protein 8: distribution and biological activity in the rat brain. J Neurosci Res. 2007 Jun; 85(8):1789-96. PMID: 17465030.
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    42. Brailoiu E, Dun SL, Brailoiu GC, Mizuo K, Sklar LA, Oprea TI, Prossnitz ER, Dun NJ. Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system. J Endocrinol. 2007 May; 193(2):311-21. PMID: 17470522.
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    43. Dun SL, Brailoiu GC, Brailoiu E, Yang J, Chang JK, Dun NJ. Distribution and biological activity of obestatin in the rat. J Endocrinol. 2006 Nov; 191(2):481-9. PMID: 17088418.
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    44. Dun SL, Brailoiu GC, Yang J, Chang JK, Dun NJ. Cocaine- and amphetamine-regulated transcript peptide and sympatho-adrenal axis. Peptides. 2006 Aug; 27(8):1949-55. PMID: 16707193.
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    45. Ng YK, Brailoiu GC, Dun SL, Ling EA, Yang J, Chang JK, Dun NJ. Beacon immunoreactivity in the rat hypothalamus. J Neurosci Res. 2006 May 1; 83(6):1106-17. PMID: 16511859.
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    46. Dun SL, Brailoiu E, Wang Y, Brailoiu GC, Liu-Chen LY, Yang J, Chang JK, Dun NJ. Insulin-like peptide 5: expression in the mouse brain and mobilization of calcium. Endocrinology. 2006 Jul; 147(7):3243-8. PMID: 16601133.
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    47. Brailoiu E, Churamani D, Pandey V, Brailoiu GC, Tuluc F, Patel S, Dun NJ. Messenger-specific role for nicotinic acid adenine dinucleotide phosphate in neuronal differentiation. J Biol Chem. 2006 Jun 9; 281(23):15923-8. PMID: 16595650.
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    48. Brailoiu E, Brailoiu GC, Mameli G, Dolei A, Sawaya BE, Dun NJ. Acute exposure to ethanol potentiates human immunodeficiency virus type 1 Tat-induced Ca(2+) overload and neuronal death in cultured rat cortical neurons. J Neurovirol. 2006 Feb; 12(1):17-24. PMID: 16595370.
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    49. Dun SL, Brailoiu GC, Mizuo K, Yang J, Chang JK, Dun NJ. Neuropeptide B immunoreactivity in the central nervous system of the rat. Brain Res. 2005 May 31; 1045(1-2):157-63. PMID: 15910774.
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    50. Brailoiu GC, Dun SL, Yin D, Yang J, Chang JK, Dun NJ. Insulin-like 6 immunoreactivity in the mouse brain and testis. Brain Res. 2005 Apr 8; 1040(1-2):187-90. PMID: 15804440.
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    51. Brailoiu GC, Dun SL, Ohsawa M, Yin D, Yang J, Chang JK, Brailoiu E, Dun NJ. KiSS-1 expression and metastin-like immunoreactivity in the rat brain. J Comp Neurol. 2005 Jan 17; 481(3):314-29. PMID: 15593369.
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    52. Brailoiu E, Hoard JL, Filipeanu CM, Brailoiu GC, Dun SL, Patel S, Dun NJ. Nicotinic acid adenine dinucleotide phosphate potentiates neurite outgrowth. J Biol Chem. 2005 Feb 18; 280(7):5646-50. PMID: 15528210.
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    53. Brailoiu E, Hoard J, Brailoiu GC, Chi M, Godbolde R, Dun NJ. Ultra low concentrations of morphine increase neurite outgrowth in cultured rat spinal cord and cerebral cortical neurons. Neurosci Lett. 2004 Jul 15; 365(1):10-3. PMID: 15234463.
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    54. Wu SY, Ohtubo Y, Brailoiu GC, Dun NJ. Effects of endomorphin on substantia gelatinosa neurons in rat spinal cord slices. Br J Pharmacol. 2003 Nov; 140(6):1088-96. PMID: 14530213.
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    55. Dun SL, Brailoiu GC, Yang J, Chang JK, Dun NJ. Neuropeptide W-immunoreactivity in the hypothalamus and pituitary of the rat. Neurosci Lett. 2003 Oct 2; 349(2):71-4. PMID: 12946555.
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    56. Brailoiu GC, Dun SL, Chi M, Ohsawa M, Chang JK, Yang J, Dun NJ. Beacon/ubiquitin-like 5-immunoreactivity in the hypothalamus and pituitary of the mouse. Brain Res. 2003 Sep 12; 984(1-2):215-23. PMID: 12932856.
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    57. Sparks GM, Brailoiu E, Brailoiu GC, Dun NJ, Tabor J, Cooper RL. Effects of m-CPP in altering neuronal function: blocking depolarization in invertebrate motor and sensory neurons but exciting rat dorsal horn neurons. Brain Res. 2003 Apr 18; 969(1-2):14-26. PMID: 12676360.
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    58. Brailoiu E, Brailoiu GC, Miyamoto MD, Dun NJ. The vasoactive peptide urotensin II stimulates spontaneous release from frog motor nerve terminals. Br J Pharmacol. 2003 Apr; 138(8):1580-8. PMID: 12721114.
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    59. Dun SL, Brailoiu GC, Parsons A, Yang J, Zeng Q, Chen X, Chang JK, Dun NJ. Metastin-like immunoreactivity in the rat medulla oblongata and spinal cord. Neurosci Lett. 2003 Jan 2; 335(3):197-201. PMID: 12531466.
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    60. Ohsawa M, Brailoiu GC, Shiraki M, Dun NJ, Paul K, Tseng LF. Modulation of nociceptive transmission by pituitary adenylate cyclase activating polypeptide in the spinal cord of the mouse. Pain. 2002 Nov; 100(1-2):27-34. PMID: 12435456.
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    61. Brailoiu GC, Dun SL, Yang J, Ohsawa M, Chang JK, Dun NJ. Apelin-immunoreactivity in the rat hypothalamus and pituitary. Neurosci Lett. 2002 Jul 26; 327(3):193-7. PMID: 12113910.
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    62. Brailoiu GC, Dun SL, Dun NJ. Glutamate receptor subunit immunoreactivity in neurons of the rat rostral ventrolateral medulla. Auton Neurosci. 2002 Jun 28; 98(1-2):55-8. PMID: 12144041.
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    63. Brailoiu GC, Lai CC, Chen CT, Hwang LL, Lin HH, Dun NJ. Sympathoinhibitory action of nociceptin in the rat spinal cord. Clin Exp Pharmacol Physiol. 2002 Mar; 29(3):233-7. PMID: 11906490.
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    64. Dun SL, Ng YK, Brailoiu GC, Ling EA, Dun NJ. Cocaine- and amphetamine-regulated transcript peptide-immunoreactivity in adrenergic C1 neurons projecting to the intermediolateral cell column of the rat. J Chem Neuroanat. 2002 Feb; 23(2):123-32. PMID: 11841916.
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    65. Brailoiu GC, Dun SL, Yang J, Chang JK, Castellino S, Dun NJ. Beacon-like immunoreactivity in the hypothalamus of Sprague-Dawley rats. Neurosci Lett. 2002 Jan 14; 317(3):166-8. PMID: 11755265.
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    66. Antunes VR, Brailoiu GC, Kwok EH, Scruggs P, Dun NJ. Orexins/hypocretins excite rat sympathetic preganglionic neurons in vivo and in vitro. Am J Physiol Regul Integr Comp Physiol. 2001 Dec; 281(6):R1801-7. PMID: 11705764.
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    67. Dun SL, Brailoiu GC, Yang J, Chang JK, Dun NJ. Urotensin II-immunoreactivity in the brainstem and spinal cord of the rat. Neurosci Lett. 2001 Jun 1; 305(1):9-12. PMID: 11356295.
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