Giovanni Pitari

TitleVolunteer Faculty
InstitutionThomas Jefferson University
DepartmentFaculty Records
Address1025 Walnut St.
Philadelphia PA 19107
Phone215-955-5647
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    R03CA133950     (PITARI, GIOVANNI M)Sep 18, 2008 - Aug 31, 2011
    NIH
    Targeting Guanylyl Cyclase C to Prevent Colorectal Tumorigenesis
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Costanzo G, Cosentino G, Grasso M, Patamia V, Zuccal? S, Coco A, Novello E, Al-Khrasani M, Morrone R, Pitari GM, Amata E, Marrazzo A, Rescifina A, Pasquinucci L, Parenti C. Novel sigma 1-antagonists with cis-(+)-normetazocine scaffold: synthesis, molecular modeling, and antinociceptive effect. RSC Med Chem. 2024 Nov 29. PMID: 39777289.
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    2. Cosentino G, Dichiara M, Ambrosio FA, Leotta CG, Costa G, Procopio F, Costanzo G, Raffa A, Artacho-Cord?n A, Ruiz-Cantero MC, Pasquinucci L, Marrazzo A, Pitari GM, Cobos EJ, Alcaro S, Amata E. Development of selective sigma-1 receptor ligands with antiallodynic activity: A focus on piperidine and piperazine scaffolds. Eur J Med Chem. 2024 Nov 10; 281:117037. PMID: 39547082.
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    3. Pedotti S, Ferreri L, Migliore R, Leotta CG, Pitari GM, D'Antona N, Petralia S, Aleo D, Sgarlata C, Consoli GML. A novel cationic ?-cyclodextrin decorated with a choline-like pendant exhibits Iodophor, Mucoadhesive and bactericidal properties. Carbohydr Polym. 2024 Mar 15; 328:121698. PMID: 38220321.
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    4. Migliore R, Ferreri L, Aleo D, Leotta CG, Pitari GM, D'Antona N, Sgarlata C, Consoli GML. p-Sulfonato-Calix[4]arene Micelles Stabilize a Povidone Iodine Solution: Supramolecular Interactions, Iodine Retention, and Bactericidal Activity. Nanomaterials (Basel). 2023 Jan 10; 13(2). PMID: 36678039.
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    5. Aruchamy B, Drago C, Russo V, Pitari GM, Ramani P, Aneesh TP, Benny S, Vishnu VR. Imidazole-pyridine hybrids as potent anti-cancer agents. Eur J Pharm Sci. 2023 Jan 01; 180:106323. PMID: 36336277.
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    6. Barbaraci C, Giurdanella G, Leotta CG, Longo A, Amata E, Dichiara M, Pasquinucci L, Turnaturi R, Prezzavento O, Cacciatore I, Zuccarello E, Lupo G, Pitari GM, Anfuso CD, Marrazzo A. Haloperidol Metabolite II Valproate Ester (S)-(-)-MRJF22: Preliminary Studies as a Potential Multifunctional Agent Against Uveal Melanoma. J Med Chem. 2021 Sep 23; 64(18):13622-13632. PMID: 34477381.
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    7. Russo V, Continella A, Drago C, Gentile A, La Malfa S, Leotta CG, Pulvirenti L, Ruberto G, Pitari GM, Siracusa L. Secondary metabolic profiles and anticancer actions from fruit extracts of immature pomegranates. PLoS One. 2021; 16(8):e0255831. PMID: 34375350.
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    8. Ali M, Zuzga DS, Pitari GM. Differential Ser phosphorylation of vasodilator-stimulated phosphoprotein regulates colon tumor formation and growth. Life Sci. 2021 Jan 01; 264:118671. PMID: 33129878.
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    9. Percipalle M, Salvaggio A, Pitari GM, Giunta RP, Aparo A, Alfonzetti T, Marino AMF. Edible insects and Toxoplasma gondii : is it something we need to be concerned about? J Food Prot. 2020 Oct 27. PMID: 33108441.
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    10. Eichinger R, Dietmüller S, Garny H, Šácha P, Birner T, Boenisch H, Pitari G, Visioni D, Stenke A, Rozanov E, Revell L, Plummer DA, Jöckel P, Oman L, Deushi M, Kinnison DE, Garcia R, Morgenstern O, Zeng G, Stone KA, Schofield R. The influence of mixing on stratospheric age of air changes in the 21st century. Atmos Chem Phys. 2019 Jan; 19(2):921-940. PMID: 32793293.
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    11. Lamy K, Portafaix T, Josse B, Brogniez C, Godin-Beekmann S, Bencherif H, Revell L, Akiyoshi H, Bekki S, Hegglin MI, Jöckel P, Kirner O, Marecal V, Morgenstern O, Stenke A, Zeng G, Abraham NL, Archibald AT, Butchart N, Chipperfield MP, Di Genova G, Deushi M, Dhomse SS, Hu RM, Kinnison D, Michou M, O'Connor FM, Oman LD, Pitari G, Plummer DA, Pyle JA, Rozanov E, Saint-Martin D, Sudo K, Tanaka TY, Visioni D, Yoshida K. Ultraviolet radiation modelling using output from the Chemistry Climate Model Initiative. Atmos Chem Phys Discuss. 2019; 19(15):10087-10110. PMID: 31632450.
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    12. Revell LE, Stenke A, Tummon F, Feinberg A, Rozanov E, Peter T, Abraham NL, Akiyoshi H, Archibald AT, Butchart N, Deushi M, Jöckel P, Kinnison D, Michou M, Morgenstern O, O'Connor FM, Oman LD, Pitari G, Plummer DA, Schofield R, Stone K, Tilmes S, Visioni D, Yamashita Y, Zeng G. Tropospheric ozone in CCMI models and Gaussian process emulation to understand biases in the SOCOLv3 chemistry-climate model. Atmos Chem Phys. 2018 Nov; 18(21):16155-16172. PMID: 32742283.
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    13. Pitari GM, Cotzia P, Ali M, Birbe R, Rizzo W, Bombonati A, Palazzo J, Solomides C, Shuber AP, Sinicrope FA, Zuzga DS. Vasodilator-Stimulated Phosphoprotein Biomarkers Are Associated with Invasion and Metastasis in Colorectal Cancer. Biomark Cancer. 2018; 10:1179299X18774551. PMID: 30911223.
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    14. Maycock AC, Randel WJ, Steiner AK, Karpechko AY, Cristy J, Saunders R, Thompson DWJ, Zou CZ, Chrysanthou A, Abraham NL, Akiyoshi H, Archibald AT, Butchart N, Chipperfield M, Dameris M, Deushi M, Dhomse S, Di Genova G, Jöckel P, Kinnison DE, Kirner O, Ladstädter F, Michou M, Morgenstern O, Connor FO, Oman L, Pitari G, Plummer DA, Revell LE, Rozanov E, Stenke A, Visioni D, Yamashita Y, Zeng G. Revisiting the mystery of recent stratospheric temperature trends. Geophys Res Lett. 2018 Sep 28; 45(18):9919-9933. PMID: 32742043.
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    15. Zhang J, Tian W, Xie F, Chipperfield MP, Feng W, Son SW, Abraham NL, Archibald AT, Bekki S, Butchart N, Deushi M, Dhomse S, Han Y, Jöckel P, Kinnison D, Kirner O, Michou M, Morgenstern O, O'Connor FM, Pitari G, Plummer DA, Revell LE, Rozanov E, Visioni D, Wang W, Zeng G. Stratospheric ozone loss over the Eurasian continent induced by the polar vortex shift. Nat Commun. 2018 01 15; 9(1):206. PMID: 29335470.
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    16. Liang Q, Chipperfield MP, Fleming EL, Abraham NL, Braesicke P, Burkholder JB, Daniel JS, Dhomse S, Fraser PJ, Hardiman SC, Jackman CH, Kinnison DE, Krummel PB, Montzka SA, Morgenstern O, McCulloch A, M?hle J, Newman PA, Orkin VL, Pitari G, Prinn RG, Rigby M, Rozanov E, Stenke A, Tummon F, Velders GJM, Visioni D, Weiss RF. Deriving Global OH Abundance and Atmospheric Lifetimes for Long-Lived Gases: A Search for CH3CCl3 Alternatives. J Geophys Res Atmos. 2017 Nov 16; 122(21):11914-11933. PMID: 38515436.
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    17. Ali M, Rogers LK, Pitari GM. Serine phosphorylation of vasodilator-stimulated phosphoprotein (VASP) regulates colon cancer cell survival and apoptosis. Life Sci. 2015 Feb 15; 123:1-8. PMID: 25543053.
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    18. Pitari GM. Pharmacology and clinical potential of guanylyl cyclase C agonists in the treatment of ulcerative colitis. Drug Des Devel Ther. 2013; 7:351-60. PMID: 23637522.
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    19. Zuzga DS, Pelta-Heller J, Li P, Bombonati A, Waldman SA, Pitari GM. Phosphorylation of vasodilator-stimulated phosphoprotein Ser239 suppresses filopodia and invadopodia in colon cancer. Int J Cancer. 2012 Jun 1; 130(11):2539-48. PMID: 21702043.
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    20. Lin JE, Li P, Snook AE, Schulz S, Dasgupta A, Hyslop TM, Gibbons AV, Marszlowicz G, Pitari GM, Waldman SA. The hormone receptor GUCY2C suppresses intestinal tumor formation by inhibiting AKT signaling. Gastroenterology. 2010 Jan; 138(1):241-54. PMID: 19737566.
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    21. Lin JE, Li P, Pitari GM, Schulz S, Waldman SA. Guanylyl cyclase C in colorectal cancer: susceptibility gene and potential therapeutic target. Future Oncol. 2009 May; 5(4):509-22. PMID: 19450179.
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    22. Lubbe WJ, Zuzga DS, Zhou Z, Fu W, Pelta-Heller J, Muschel RJ, Waldman SA, Pitari GM. Guanylyl cyclase C prevents colon cancer metastasis by regulating tumor epithelial cell matrix metalloproteinase-9. Cancer Res. 2009 Apr 15; 69(8):3529-36. PMID: 19336567.
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    23. Zuzga DS, Gibbons AV, Li P, Lubbe WJ, Chervoneva I, Pitari GM. Overexpression of matrix metalloproteinase 9 in tumor epithelial cells correlates with colorectal cancer metastasis. Clin Transl Sci. 2008 Sep; 1(2):136-41. PMID: 20443834.
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    24. Li P, Schulz S, Pitari GM, Waldman SA. Sex modulates intestinal transformation by the tumor-suppressor GCC. Clin Transl Sci. 2008 Sep; 1(2):146-50. PMID: 20443837.
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    25. Li P, Schulz S, Pitari GM, Waldman SA. Sex modulates intestinal transformation by the tumor-suppressor GCC. Clin Transl Sci. 2008 Sep; 1(2):150. PMID: 20443838.
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    26. Pitari GM, Lin JE, Shah FJ, Lubbe WJ, Zuzga DS, Li P, Schulz S, Waldman SA. Enterotoxin preconditioning restores calcium-sensing receptor-mediated cytostasis in colon cancer cells. Carcinogenesis. 2008 Aug; 29(8):1601-7. PMID: 18566015.
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    27. Li P, Lin JE, Chervoneva I, Schulz S, Waldman SA, Pitari GM. Homeostatic control of the crypt-villus axis by the bacterial enterotoxin receptor guanylyl cyclase C restricts the proliferating compartment in intestine. Am J Pathol. 2007 Dec; 171(6):1847-58. PMID: 17974601.
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    28. Li P, Schulz S, Bombonati A, Palazzo JP, Hyslop TM, Xu Y, Baran AA, Siracusa LD, Pitari GM, Waldman SA. Guanylyl cyclase C suppresses intestinal tumorigenesis by restricting proliferation and maintaining genomic integrity. Gastroenterology. 2007 Aug; 133(2):599-607. PMID: 17681179.
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    29. Pitari GM, Li T, Baksh RI, Waldman SA. Exisulind and guanylyl cyclase C induce distinct antineoplastic signaling mechanisms in human colon cancer cells. Mol Cancer Ther. 2006 May; 5(5):1190-6. PMID: 16731751.
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    30. Debruyne PR, Witek M, Gong L, Birbe R, Chervoneva I, Jin T, Domon-Cell C, Palazzo JP, Freund JN, Li P, Pitari GM, Schulz S, Waldman SA. Bile acids induce ectopic expression of intestinal guanylyl cyclase C Through nuclear factor-kappaB and Cdx2 in human esophageal cells. Gastroenterology. 2006 Apr; 130(4):1191-206. PMID: 16618413.
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    31. Lubbe WJ, Zhou ZY, Fu W, Zuzga D, Schulz S, Fridman R, Muschel RJ, Waldman SA, Pitari GM. Tumor epithelial cell matrix metalloproteinase 9 is a target for antimetastatic therapy in colorectal cancer. Clin Cancer Res. 2006 Mar 15; 12(6):1876-82. PMID: 16551873.
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    32. Pitari GM, Baksh RI, Harris DM, Li P, Kazerounian S, Waldman SA. Interruption of homologous desensitization in cyclic guanosine 3',5'-monophosphate signaling restores colon cancer cytostasis by bacterial enterotoxins. Cancer Res. 2005 Dec 1; 65(23):11129-35. PMID: 16322263.
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    33. Frick GS, Pitari GM, Weinberg DS, Hyslop T, Schulz S, Waldman SA. Guanylyl cyclase C: a molecular marker for staging and postoperative surveillance of patients with colorectal cancer. Expert Rev Mol Diagn. 2005 Sep; 5(5):701-13. PMID: 16149873.
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    34. Kazerounian S, Pitari GM, Shah FJ, Frick GS, Madesh M, Ruiz-Stewart I, Schulz S, Hajnóczky G, Waldman SA. Proliferative signaling by store-operated calcium channels opposes colon cancer cell cytostasis induced by bacterial enterotoxins. J Pharmacol Exp Ther. 2005 Sep; 314(3):1013-22. PMID: 15937149.
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    35. Gong L, Pitari GM, Schulz S, Waldman SA. Nitric oxide signaling: systems integration of oxygen balance in defense of cell integrity. Curr Opin Hematol. 2004 Jan; 11(1):7-14. PMID: 14676622.
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    36. Tiyyagura SR, Kazerounian S, Schulz S, Waldman SA, Pitari GM. Reciprocal regulation and integration of signaling by intracellular calcium and cyclic GMP. Vitam Horm. 2004; 69:69-94. PMID: 15196879.
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    37. Burke J, Kraft WK, Greenberg HE, Gleave M, Pitari GM, VanBuren S, Wagner JA, Waldman SA. Relationship of arachidonic acid concentration to cyclooxygenase-dependent human platelet aggregation. J Clin Pharmacol. 2003 Sep; 43(9):983-9. PMID: 12971030.
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    38. Chiarugi A, Pitari GM, Costa R, Ferrante M, Villari L, Amico-Roxas M, Godfraind T, Bianchi A, Salomone S. Effect of prolonged incubation with copper on endothelium-dependent relaxation in rat isolated aorta. Br J Pharmacol. 2002 Aug; 136(8):1185-93. PMID: 12163352.
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    39. Ruiz-Stewart I, Kazerounian S, Pitari GM, Schulz S, Waldman SA. Soluble guanylate cyclase is allosterically inhibited by direct interaction with 2-substituted adenine nucleotides. Eur J Biochem. 2002 Apr; 269(8):2186-93. PMID: 11985597.
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    40. Kazerounian S, Pitari GM, Ruiz-Stewart I, Schulz S, Waldman SA. Nitric oxide activation of soluble guanylyl cyclase reveals high and low affinity sites that mediate allosteric inhibition by calcium. Biochemistry. 2002 Mar 12; 41(10):3396-404. PMID: 11876648.
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