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Jeffrey Benovic

TitleProfessor
InstitutionThomas Jefferson University
DepartmentBiochem & Molecular Biology
Address233 S. 10th Street
Philadelphia PA 19107
Phone215-503-4607
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    Collapse Research 
    Collapse research activities and funding
    R01GM044944     (BENOVIC, JEFFREY L.)Jul 1, 1990 - Apr 30, 2017
    NIH/NIGMS
    G Protein-Coupled Receptor Kinases
    Role: Principal Investigator
    R01HL045964     (BENOVIC, JEFFREY L)Sep 30, 1990 - Sep 30, 1995
    NIH/NHLBI
    BETA-ADRENERGIC RECEPTOR REGULATION IN AIRWAY EPITHELIUM
    Role: Principal Investigator
    R01GM047417     (BENOVIC, JEFFREY L)Jan 1, 1994 - Feb 28, 2006
    NIH/NIGMS
    ARRESTINS IN G PROTEIN-COUPLE RECEPTOR REGULATION
    Role: Principal Investigator
    R37GM047417     (BENOVIC, JEFFREY L.)Jan 1, 1994 - Feb 29, 2016
    NIH/NIGMS
    Role of Arrestins in G Protein-Coupled Receptor Regulation
    Role: Principal Investigator
    T32DK007705     (BENOVIC, JEFFREY L)Jun 1, 1994 - May 31, 2010
    NIH/NIDDK
    Training Program in Biomolecular Signal Transduction
    Role: Principal Investigator
    T35HL007845     (BENOVIC, JEFFREY L)Apr 1, 1996 - Jul 31, 2008
    NIH/NHLBI
    Short-term Training Students in Health Professional Sch.
    Role: Principal Investigator
    R13CA102093     (BENOVIC, JEFFREY L)Jun 1, 2003 - May 31, 2006
    NIH/NCI
    GRC on Second Messengers &Protein Phosphorylation
    Role: Principal Investigator
    R01GM068857     (BENOVIC, JEFFREY L)Jul 1, 2003 - Jun 30, 2008
    NIH/NIGMS
    Arestin Interaction with Endocytic Components
    Role: Principal Investigator
    R01CA129626     (BENOVIC, JEFFREY L)Jul 11, 2007 - May 31, 2013
    NIH/NCI
    Regulation of CXCR4 Signaling
    Role: Principal Investigator
    T32GM100836     (BENOVIC, JEFFREY L.)Jul 1, 2012 - Jun 30, 2017
    NIH/NIGMS
    Training Program in Cellular, Biochemical, and Molecular Sciences
    Role: Principal Investigator
    R01HL136219     (BENOVIC, JEFFREY L)Jan 9, 2017 - Dec 31, 2020
    NIH/NHLBI
    Characterization of beta-arrestin-biased beta 2-adrenergic receptor signaling in cardiovascular function
    Role: Principal Investigator
    R35GM122541     (BENOVIC, JEFFREY L)Aug 1, 2017 - Jul 31, 2022
    NIH/NIGMS
    Regulation of G protein-coupled receptor signaling and trafficking
    Role: Principal Investigator
    R01HL142310     (BENOVIC, JEFFREY L.)Apr 1, 2018 - Mar 31, 2022
    NIH/NHLBI
    Structural and dynamic analysis of GRK interaction with G protein-coupled receptors
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Lapadula D, Farias E, Randolph CE, Purwin T, McGrath D, Charpentier T, Zhang L, Wu S, Terai M, Sato T, Tall GG, Zhou N, Wedegaertner P, Aplin AE, Aguirre-Ghiso J, Benovic JL. Effects of Oncogenic Gaq and Ga11 Inhibition by FR900359 in Uveal Melanoma. Mol Cancer Res. 2018 Dec 19. PMID: 30567972.
      View in: PubMed
    2. Grisanti LA, Thomas TP, Carter RL, de Lucia C, Gao E, Koch WJ, Benovic JL, Tilley DG. Pepducin-mediated cardioprotection via ß-arrestin-biased ß2-adrenergic receptor-specific signaling. Theranostics. 2018; 8(17):4664-4678. PMID: 30279730.
      View in: PubMed
    3. Chaturvedi M, Schilling J, Beautrait A, Bouvier M, Benovic JL, Shukla AK. Emerging Paradigm of Intracellular Targeting of G Protein-Coupled Receptors. Trends Biochem Sci. 2018 Jul; 43(7):533-546. PMID: 29735399.
      View in: PubMed
    4. Panettieri RA, Pera T, Liggett SB, Benovic JL, Penn RB. Pepducins as a potential treatment strategy for asthma and COPD. Curr Opin Pharmacol. 2018 Jun; 40:120-125. PMID: 29729548.
      View in: PubMed
    5. Pera T, Deshpande DA, Ippolito M, Wang B, Gavrila A, Michael JV, Nayak AP, Tompkins E, Farrell E, Kroeze WK, Roth BL, Panettieri RA, Benovic JL, An SS, Dulin NO, Penn RB. Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines. FASEB J. 2018 Feb; 32(2):862-874. PMID: 29042451.
      View in: PubMed
    6. Komolov KE, Benovic JL. G protein-coupled receptor kinases: Past, present and future. Cell Signal. 2018 Jan; 41:17-24. PMID: 28711719.
      View in: PubMed
    7. Komolov KE, Du Y, Duc NM, Betz RM, Rodrigues JPGLM, Leib RD, Patra D, Skiniotis G, Adams CM, Dror RO, Chung KY, Kobilka BK, Benovic JL. Structural and Functional Analysis of a ß2-Adrenergic Receptor Complex with GRK5. Cell. 2017 Apr 20; 169(3):407-421.e16. PMID: 28431242.
      View in: PubMed
    8. Luo J, Busillo JM, Stumm R, Benovic JL. G Protein-Coupled Receptor Kinase 3 and Protein Kinase C Phosphorylate the Distal C-Terminal Tail of the Chemokine Receptor CXCR4 and Mediate Recruitment of ß-Arrestin. Mol Pharmacol. 2017 Jun; 91(6):554-566. PMID: 28331048.
      View in: PubMed
    9. Chua V, Lapadula D, Randolph C, Benovic JL, Wedegaertner PB, Aplin AE. Dysregulated GPCR Signaling and Therapeutic Options in Uveal Melanoma. Mol Cancer Res. 2017 May; 15(5):501-506. PMID: 28223438.
      View in: PubMed
    10. Wang J, Luo J, Aryal DK, Wetsel WC, Nass R, Benovic JL. G protein-coupled receptor kinase-2 (GRK-2) regulates serotonin metabolism through the monoamine oxidase AMX-2 in Caenorhabditis elegans. J Biol Chem. 2017 Apr 07; 292(14):5943-5956. PMID: 28213524.
      View in: PubMed
    11. DeRita RM, Zerlanko B, Singh A, Lu H, Iozzo RV, Benovic JL, Languino LR. c-Src, Insulin-Like Growth Factor I Receptor, G-Protein-Coupled Receptor Kinases and Focal Adhesion Kinase are Enriched Into Prostate Cancer Cell Exosomes. J Cell Biochem. 2017 Jan; 118(1):66-73. PMID: 27232975.
      View in: PubMed
    12. Carr R, Schilling J, Song J, Carter RL, Du Y, Yoo SM, Traynham CJ, Koch WJ, Cheung JY, Tilley DG, Benovic JL. ß-arrestin-biased signaling through the ß2-adrenergic receptor promotes cardiomyocyte contraction. Proc Natl Acad Sci U S A. 2016 Jul 12; 113(28):E4107-16. PMID: 27354517.
      View in: PubMed
    13. Tian X, Irannejad R, Bowman SL, Du Y, Puthenveedu MA, von Zastrow M, Benovic JL. The a-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the ß2-Adrenergic Receptor. J Biol Chem. 2016 Jul 8; 291(28):14510-25. PMID: 27226565.
      View in: PubMed
    14. Carr R, Benovic JL. From biased signalling to polypharmacology: unlocking unique intracellular signalling using pepducins. Biochem Soc Trans. 2016 Apr 15; 44(2):555-61. PMID: 27068969.
      View in: PubMed
    15. Carr R, Koziol-White C, Zhang J, Lam H, An SS, Tall GG, Panettieri RA, Benovic JL. Interdicting Gq Activation in Airway Disease by Receptor-Dependent and Receptor-Independent Mechanisms. Mol Pharmacol. 2016 Jan; 89(1):94-104. PMID: 26464325.
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    16. Benovic JL. Structural biology: Arresting developments in receptor signalling. Nature. 2015 Jul 30; 523(7562):538-9. PMID: 26200346.
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    17. Komolov KE, Bhardwaj A, Benovic JL. Atomic Structure of GRK5 Reveals Distinct Structural Features Novel for G Protein-coupled Receptor Kinases. J Biol Chem. 2015 Aug 21; 290(34):20629-47. PMID: 26032409.
      View in: PubMed
    18. Augello MA, Berman-Booty LD, Carr R, Yoshida A, Dean JL, Schiewer MJ, Feng FY, Tomlins SA, Gao E, Koch WJ, Benovic JL, Diehl JA, Knudsen KE. Consequence of the tumor-associated conversion to cyclin D1b. EMBO Mol Med. 2015; 7(5):628-47. PMID: 25787974.
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    19. Martinez-Martin N, Viejo-Borbolla A, Martín R, Blanco S, Benovic JL, Thelen M, Alcamí A. Herpes simplex virus enhances chemokine function through modulation of receptor trafficking and oligomerization. Nat Commun. 2015; 6:6163. PMID: 25625471.
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    20. Benovic JL, Armstrong RN. New frontiers in kinases. Biochemistry. 2015 Jan 13; 54(1):1. PMID: 25517407.
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    21. Carr R, Du Y, Quoyer J, Panettieri RA, Janz JM, Bouvier M, Kobilka BK, Benovic JL. Development and Characterization of Pepducins as Gs-biased Allosteric Agonists. J Biol Chem. 2014 Dec 26; 289(52):35668-84. PMID: 25395624.
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    22. Benovic JL, Armstrong RN. Call for Papers! A Special Thematic Compilation/Special Issue Crossover with ACS Chemical Biology, ACS Medicinal Chemistry Letters, and the Journal of Medicinal Chemistry Focused on New Frontiers in Kinases. Biochemistry. 2014 Mar 25; 53(11):1723. PMID: 24660987.
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    23. Benovic JL, von Zastrow M. Editorial overview: Cell regulation: The ins and outs of G protein-coupled receptors. Curr Opin Cell Biol. 2014 Apr; 27:v-vi. PMID: 24529749.
      View in: PubMed
    24. Tian X, Kang DS, Benovic JL. ß-Arrestins and G Protein-Coupled Receptor Trafficking. Handb Exp Pharmacol. 2014; 219:173-86. PMID: 24292830.
      View in: PubMed
    25. Kang DS, Tian X, Benovic JL. Role of ß-arrestins and arrestin domain-containing proteins in G protein-coupled receptor trafficking. Curr Opin Cell Biol. 2014 Apr; 27:63-71. PMID: 24680432.
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    26. Quoyer J, Janz JM, Luo J, Ren Y, Armando S, Lukashova V, Benovic JL, Carlson KE, Hunt SW, Bouvier M. Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein. Proc Natl Acad Sci U S A. 2013 Dec 24; 110(52):E5088-97. PMID: 24309376.
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    27. So CH, Michal A, Komolov KE, Luo J, Benovic JL. G protein-coupled receptor kinase 2 (GRK2) is localized to centrosomes and mediates epidermal growth factor-promoted centrosomal separation. Mol Biol Cell. 2013 Sep; 24(18):2795-806. PMID: 23904266.
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    28. Kang DS, Tian X, Benovic JL. ß-Arrestins and G Protein-Coupled Receptor Trafficking. Methods Enzymol. 2013; 521:91-108. PMID: 23351735.
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    29. Chen YJ, Oldfield S, Butcher AJ, Tobin AB, Saxena K, Gurevich VV, Benovic JL, Henderson G, Kelly E. Identification of phosphorylation sites in the COOH-terminal tail of the µ-opioid receptor. J Neurochem. 2013 Jan; 124(2):189-99. PMID: 23106126.
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    30. Benovic JL. G-protein-coupled receptors signal victory. Cell. 2012 Dec 7; 151(6):1148-50. PMID: 23201142.
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    31. Li G, Zhou Q, Yu Y, Chen L, Shi Y, Luo J, Benovic J, Lu J, Zhou N. Identification and characterization of distinct C-terminal domains of the human hydroxycarboxylic Acid receptor-2 that are essential for receptor export, constitutive activity, desensitization, and internalization. Mol Pharmacol. 2012 Dec; 82(6):1150-61. PMID: 22962331.
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    32. So CH, Michal AM, Mashayekhi R, Benovic JL. G protein-coupled receptor kinase 5 phosphorylates nucleophosmin and regulates cell sensitivity to polo-like kinase 1 inhibition. J Biol Chem. 2012 May 18; 287(21):17088-99. PMID: 22467873.
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    33. Wood JF, Wang J, Benovic JL, Ferkey DM. Structural domains required for Caenorhabditis elegans G protein-coupled receptor kinase 2 (GRK-2) function in vivo. J Biol Chem. 2012 Apr 13; 287(16):12634-44. PMID: 22375004.
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    34. Michal AM, So CH, Beeharry N, Shankar H, Mashayekhi R, Yen TJ, Benovic JL. G Protein-coupled receptor kinase 5 is localized to centrosomes and regulates cell cycle progression. J Biol Chem. 2012 Feb 24; 287(9):6928-40. PMID: 22223642.
      View in: PubMed
    35. Woerner BM, Luo J, Brown KR, Jackson E, Dahiya SM, Mischel P, Benovic JL, Piwnica-Worms D, Rubin JB. Suppression of G-protein-coupled receptor kinase 3 expression is a feature of classical GBM that is required for maximal growth. Mol Cancer Res. 2012 Jan; 10(1):156-66. PMID: 22086906.
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    36. Barker BL, Benovic JL. G protein-coupled receptor kinase 5 phosphorylation of hip regulates internalization of the chemokine receptor CXCR4. Biochemistry. 2011 Aug 16; 50(32):6933-41. PMID: 21728385.
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    37. Michal AM, Peck AR, Tran TH, Liu C, Rimm DL, Rui H, Benovic JL. Differential expression of arrestins is a predictor of breast cancer progression and survival. Breast Cancer Res Treat. 2011 Dec; 130(3):791-807. PMID: 21318602.
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    38. Sosa MS, Lopez-Haber C, Yang C, Wang H, Lemmon MA, Busillo JM, Luo J, Benovic JL, Klein-Szanto A, Yagi H, Gutkind JS, Parsons RE, Kazanietz MG. Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer. Mol Cell. 2010 Dec 22; 40(6):877-92. PMID: 21172654.
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    39. Huang H, He X, Deng X, Li G, Ying G, Sun Y, Shi L, Benovic JL, Zhou N. Bombyx adipokinetic hormone receptor activates extracellular signal-regulated kinase 1 and 2 via G protein-dependent PKA and PKC but ß-arrestin-independent pathways. Biochemistry. 2010 Dec 28; 49(51):10862-72. PMID: 21126059.
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    40. Li G, Shi Y, Huang H, Zhang Y, Wu K, Luo J, Sun Y, Lu J, Benovic JL, Zhou N. Internalization of the human nicotinic acid receptor GPR109A is regulated by G(i), GRK2, and arrestin3. J Biol Chem. 2010 Jul 16; 285(29):22605-18. PMID: 20460384.
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    41. Palmitessa A, Benovic JL. Arrestin and the multi-PDZ domain-containing protein MPZ-1 interact with phosphatase and tensin homolog (PTEN) and regulate Caenorhabditis elegans longevity. J Biol Chem. 2010 May 14; 285(20):15187-200. PMID: 20207731.
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    42. Shankar H, Michal A, Kern RC, Kang DS, Gurevich VV, Benovic JL. Non-visual arrestins are constitutively associated with the centrosome and regulate centrosome function. J Biol Chem. 2010 Mar 12; 285(11):8316-29. PMID: 20056609.
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    43. Busillo JM, Armando S, Sengupta R, Meucci O, Bouvier M, Benovic JL. Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling. J Biol Chem. 2010 Mar 5; 285(10):7805-17. PMID: 20048153.
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    44. Patial S, Luo J, Porter KJ, Benovic JL, Parameswaran N. G-protein-coupled-receptor kinases mediate TNFa-induced NF?B signalling via direct interaction with and phosphorylation of I?Ba. Biochem J. 2010 Jan 1; 425(1):169-78. PMID: 19796012.
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    45. Kang DS, Kern RC, Puthenveedu MA, von Zastrow M, Williams JC, Benovic JL. Structure of an arrestin2-clathrin complex reveals a novel clathrin binding domain that modulates receptor trafficking. J Biol Chem. 2009 Oct 23; 284(43):29860-72. PMID: 19710023.
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    46. Barthet G, Carrat G, Cassier E, Barker B, Gaven F, Pillot M, Framery B, Pellissier LP, Augier J, Kang DS, Claeysen S, Reiter E, Banères JL, Benovic JL, Marin P, Bockaert J, Dumuis A. Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling. EMBO J. 2009 Sep 16; 28(18):2706-18. PMID: 19661922.
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    47. Kern RC, Kang DS, Benovic JL. Arrestin2/clathrin interaction is regulated by key N- and C-terminal regions in arrestin2. Biochemistry. 2009 Aug 4; 48(30):7190-200. PMID: 19555118.
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    48. Pao CS, Barker BL, Benovic JL. Role of the amino terminus of G protein-coupled receptor kinase 2 in receptor phosphorylation. Biochemistry. 2009 Aug 4; 48(30):7325-33. PMID: 19715378.
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    49. Lakshmikanthan V, Zou L, Kim JI, Michal A, Nie Z, Messias NC, Benovic JL, Daaka Y. Identification of betaArrestin2 as a corepressor of androgen receptor signaling in prostate cancer. Proc Natl Acad Sci U S A. 2009 Jun 9; 106(23):9379-84. PMID: 19458261.
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    50. Zhu C, Huang H, Hua R, Li G, Yang D, Luo J, Zhang C, Shi L, Benovic JL, Zhou N. Molecular and functional characterization of adipokinetic hormone receptor and its peptide ligands in Bombyx mori. FEBS Lett. 2009 May 6; 583(9):1463-8. PMID: 19345219.
      View in: PubMed
    51. Yang M, He RL, Benovic JL, Ye RD. beta-Arrestin1 interacts with the G-protein subunits beta1gamma2 and promotes beta1gamma2-dependent Akt signalling for NF-kappaB activation. Biochem J. 2009 Jan 1; 417(1):287-96. PMID: 18729826.
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    52. Luo J, Busillo JM, Benovic JL. M3 muscarinic acetylcholine receptor-mediated signaling is regulated by distinct mechanisms. Mol Pharmacol. 2008 Aug; 74(2):338-47. PMID: 18388243.
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    53. Ahmed MR, Gurevich VV, Dalby KN, Benovic JL, Gurevich EV. Haloperidol and clozapine differentially affect the expression of arrestins, receptor kinases, and extracellular signal-regulated kinase activation. J Pharmacol Exp Ther. 2008 Apr; 325(1):276-83. PMID: 18178904.
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    54. Penn RB, Benovic JL. Regulation of heterotrimeric G protein signaling in airway smooth muscle. Proc Am Thorac Soc. 2008 Jan 1; 5(1):47-57. PMID: 18094084.
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    55. Ahmed MR, Bychkov E, Gurevich VV, Benovic JL, Gurevich EV. Altered expression and subcellular distribution of GRK subtypes in the dopamine-depleted rat basal ganglia is not normalized by l-DOPA treatment. J Neurochem. 2008 Mar; 104(6):1622-36. PMID: 17996024.
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    56. Bhandari D, Trejo J, Benovic JL, Marchese A. Arrestin-2 interacts with the ubiquitin-protein isopeptide ligase atrophin-interacting protein 4 and mediates endosomal sorting of the chemokine receptor CXCR4. J Biol Chem. 2007 Dec 21; 282(51):36971-9. PMID: 17947233.
      View in: PubMed
    57. Jiang X, Benovic JL, Wedegaertner PB. Plasma membrane and nuclear localization of G protein coupled receptor kinase 6A. Mol Biol Cell. 2007 Aug; 18(8):2960-9. PMID: 17538017.
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    58. Moore CA, Milano SK, Benovic JL. Regulation of receptor trafficking by GRKs and arrestins. Annu Rev Physiol. 2007; 69:451-82. PMID: 17037978.
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    59. Busillo JM, Benovic JL. Regulation of CXCR4 signaling. Biochim Biophys Acta. 2007 Apr; 1768(4):952-63. PMID: 17169327.
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    60. Parameswaran N, Pao CS, Leonhard KS, Kang DS, Kratz M, Ley SC, Benovic JL. Arrestin-2 and G protein-coupled receptor kinase 5 interact with NFkappaB1 p105 and negatively regulate lipopolysaccharide-stimulated ERK1/2 activation in macrophages. J Biol Chem. 2006 Nov 10; 281(45):34159-70. PMID: 16980301.
      View in: PubMed
    61. Mundell SJ, Luo J, Benovic JL, Conley PB, Poole AW. Distinct clathrin-coated pits sort different G protein-coupled receptor cargo. Traffic. 2006 Oct; 7(10):1420-31. PMID: 16899088.
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    62. Lodowski DT, Tesmer VM, Benovic JL, Tesmer JJ. The structure of G protein-coupled receptor kinase (GRK)-6 defines a second lineage of GRKs. J Biol Chem. 2006 Jun 16; 281(24):16785-93. PMID: 16613860.
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    63. Milano SK, Kim YM, Stefano FP, Benovic JL, Brenner C. Nonvisual arrestin oligomerization and cellular localization are regulated by inositol hexakisphosphate binding. J Biol Chem. 2006 Apr 7; 281(14):9812-23. PMID: 16439357.
      View in: PubMed
    64. Palmitessa A, Hess HA, Bany IA, Kim YM, Koelle MR, Benovic JL. Caenorhabditus elegans arrestin regulates neural G protein signaling and olfactory adaptation and recovery. J Biol Chem. 2005 Jul 1; 280(26):24649-62. PMID: 15878875.
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    65. Hardy AR, Conley PB, Luo J, Benovic JL, Poole AW, Mundell SJ. P2Y1 and P2Y12 receptors for ADP desensitize by distinct kinase-dependent mechanisms. Blood. 2005 May 1; 105(9):3552-60. PMID: 15665114.
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    66. Pao CS, Benovic JL. Structure/function analysis of alpha2A-adrenergic receptor interaction with G protein-coupled receptor kinase 2. J Biol Chem. 2005 Mar 25; 280(12):11052-8. PMID: 15653687.
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    67. Rutherford C, Ord-Shrimpton FU, Sands WA, Pediani JD, Benovic JL, McGrath JC, Palmer TM. Phosphorylation-independent internalisation and desensitisation of the human sphingosine-1-phosphate receptor S1P3. Cell Signal. 2005 Aug; 17(8):997-1009. PMID: 15894172.
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    68. Naik S, Billington CK, Pascual RM, Deshpande DA, Stefano FP, Kohout TA, Eckman DM, Benovic JL, Penn RB. Regulation of cysteinyl leukotriene type 1 receptor internalization and signaling. J Biol Chem. 2005 Mar 11; 280(10):8722-32. PMID: 15590629.
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    69. Gurevich EV, Benovic JL, Gurevich VV. Arrestin2 expression selectively increases during neural differentiation. J Neurochem. 2004 Dec; 91(6):1404-16. PMID: 15584917.
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    70. Iwata K, Luo J, Penn RB, Benovic JL. Bimodal regulation of the human H1 histamine receptor by G protein-coupled receptor kinase 2. J Biol Chem. 2005 Jan 21; 280(3):2197-204. PMID: 15542600.
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    71. Benovic JL, Marchese A. A new key in breast cancer metastasis. Cancer Cell. 2004 Nov; 6(5):429-30. PMID: 15542424.
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    72. Day PW, Tesmer JJ, Sterne-Marr R, Freeman LC, Benovic JL, Wedegaertner PB. Characterization of the GRK2 binding site of Galphaq. J Biol Chem. 2004 Dec 17; 279(51):53643-52. PMID: 15471870.
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    73. Thiyagarajan MM, Stracquatanio RP, Pronin AN, Evanko DS, Benovic JL, Wedegaertner PB. A predicted amphipathic helix mediates plasma membrane localization of GRK5. J Biol Chem. 2004 Apr 23; 279(17):17989-95. PMID: 14976207.
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    74. Marchese A, Benovic JL. Ubiquitination of G-protein-coupled receptors. Methods Mol Biol. 2004; 259:299-305. PMID: 15250500.
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    75. Day PW, Wedegaertner PB, Benovic JL. Analysis of G-protein-coupled receptor kinase RGS homology domains. Methods Enzymol. 2004; 390:295-310. PMID: 15488185.
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    76. Gutierrez-Ford C, Levay K, Gomes AV, Perera EM, Som T, Kim YM, Benovic JL, Berkovitz GD, Slepak VZ. Characterization of tescalcin, a novel EF-hand protein with a single Ca2+-binding site: metal-binding properties, localization in tissues and cells, and effect on calcineurin. Biochemistry. 2003 Dec 16; 42(49):14553-65. PMID: 14661968.
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    77. Marchese A, Raiborg C, Santini F, Keen JH, Stenmark H, Benovic JL. The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4. Dev Cell. 2003 Nov; 5(5):709-22. PMID: 14602072.
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    78. Luo J, Benovic JL. G protein-coupled receptor kinase interaction with Hsp90 mediates kinase maturation. J Biol Chem. 2003 Dec 19; 278(51):50908-14. PMID: 14557268.
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    79. Vishnivetskiy SA, Hosey MM, Benovic JL, Gurevich VV. Mapping the arrestin-receptor interface. Structural elements responsible for receptor specificity of arrestin proteins. J Biol Chem. 2004 Jan 9; 279(2):1262-8. PMID: 14530255.
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    80. Noble B, Kallal LA, Pausch MH, Benovic JL. Development of a yeast bioassay to characterize G protein-coupled receptor kinases. Identification of an NH2-terminal region essential for receptor phosphorylation. J Biol Chem. 2003 Nov 28; 278(48):47466-76. PMID: 14507916.
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    81. Day PW, Carman CV, Sterne-Marr R, Benovic JL, Wedegaertner PB. Differential interaction of GRK2 with members of the G alpha q family. Biochemistry. 2003 Aug 5; 42(30):9176-84. PMID: 12885252.
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    82. Marchese A, Chen C, Kim YM, Benovic JL. The ins and outs of G protein-coupled receptor trafficking. Trends Biochem Sci. 2003 Jul; 28(7):369-76. PMID: 12878004.
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    83. Benovic JL. Novel beta2-adrenergic receptor signaling pathways. J Allergy Clin Immunol. 2002 Dec; 110(6 Suppl):S229-35. PMID: 12464929.
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    84. Sterne-Marr R, Tesmer JJ, Day PW, Stracquatanio RP, Cilente JA, O'Connor KE, Pronin AN, Benovic JL, Wedegaertner PB. G protein-coupled receptor Kinase 2/G alpha q/11 interaction. A novel surface on a regulator of G protein signaling homology domain for binding G alpha subunits. J Biol Chem. 2003 Feb 21; 278(8):6050-8. PMID: 12427730.
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    85. Pao CS, Benovic JL. Phosphorylation-independent desensitization of G protein-coupled receptors? Sci STKE. 2002 Oct 8; 2002(153):pe42. PMID: 12372852.
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    86. DeGraff JL, Gurevich VV, Benovic JL. The third intracellular loop of alpha 2-adrenergic receptors determines subtype specificity of arrestin interaction. J Biol Chem. 2002 Nov 8; 277(45):43247-52. PMID: 12205092.
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    87. Kim YM, Benovic JL. Differential roles of arrestin-2 interaction with clathrin and adaptor protein 2 in G protein-coupled receptor trafficking. J Biol Chem. 2002 Aug 23; 277(34):30760-8. PMID: 12070169.
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    88. Milano SK, Pace HC, Kim YM, Brenner C, Benovic JL. Scaffolding functions of arrestin-2 revealed by crystal structure and mutagenesis. Biochemistry. 2002 Mar 12; 41(10):3321-8. PMID: 11876640.
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    89. Kim YM, Barak LS, Caron MG, Benovic JL. Regulation of arrestin-3 phosphorylation by casein kinase II. J Biol Chem. 2002 May 10; 277(19):16837-46. PMID: 11877451.
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    90. Handley DA, Senanayake CH, Dutczak W, Benovic JL, Walle T, Penn RB, Wilkinson HS, Tanoury GJ, Andersson RG, Johansson F, Morley J. Biological actions of formoterol isomers. Pulm Pharmacol Ther. 2002; 15(2):135-45. PMID: 12090787.
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    91. Kallal L, Benovic JL. Fluorescence microscopy techniques for the study of G protein-coupled receptor trafficking. Methods Enzymol. 2002; 343:492-506. PMID: 11665588.
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    92. Pronin AN, Loudon RP, Benovic JL. Characterization of G protein-coupled receptor kinases. Methods Enzymol. 2002; 343:547-59. PMID: 11665591.
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    93. Mundell SJ, Orsini MJ, Benovic JL. Characterization of arrestin expression and function. Methods Enzymol. 2002; 343:600-11. PMID: 11665594.
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    94. Watterson KR, Johnston E, Chalmers C, Pronin A, Cook SJ, Benovic JL, Palmer TM. Dual regulation of EDG1/S1P(1) receptor phosphorylation and internalization by protein kinase C and G-protein-coupled receptor kinase 2. J Biol Chem. 2002 Feb 22; 277(8):5767-77. PMID: 11741892.
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