Thomas Jefferson University

Jeffrey Benovic

TitleProfessor ETO
InstitutionThomas Jefferson University
DepartmentBiochemistry & Molecular Biology - Thomas Jefferson University
Address951 Locust Street
Philadelphia PA 19107
Phone2155034607
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    Collapse Research 
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    R01GM044944     (BENOVIC, JEFFREY L)Jul 1, 1990 - Apr 30, 2018
    NIH
    G Protein-Coupled Receptor Kinases
    Role: Principal Investigator
    R01HL045964     (BENOVIC, JEFFREY L)Sep 30, 1990 - Sep 30, 1995
    NIH
    BETA-ADRENERGIC RECEPTOR REGULATION IN AIRWAY EPITHELIUM
    Role: Principal Investigator
    R01GM047417     (BENOVIC, JEFFREY L)Jan 1, 1994 - Feb 28, 2006
    NIH
    ARRESTINS IN G PROTEIN-COUPLE RECEPTOR REGULATION
    Role: Principal Investigator
    R37GM047417     (BENOVIC, JEFFREY L)Jan 1, 1994 - Feb 28, 2018
    NIH
    Role of Arrestins in G Protein-Coupled Receptor Regulation
    Role: Principal Investigator
    T32DK007705     (BENOVIC, JEFFREY L)Jun 1, 1994 - May 31, 2010
    NIH
    Training Program in Biomolecular Signal Transduction
    Role: Principal Investigator
    T35HL007845     (BENOVIC, JEFFREY L)Apr 1, 1996 - Jul 31, 2008
    NIH
    Short-term Training Students in Health Professional Sch.
    Role: Principal Investigator
    R13CA102093     (BENOVIC, JEFFREY L)Jun 1, 2003 - May 31, 2006
    NIH
    GRC on Second Messengers &Protein Phosphorylation
    Role: Principal Investigator
    R01GM068857     (BENOVIC, JEFFREY L)Jul 1, 2003 - Jun 30, 2008
    NIH
    Arestin Interaction with Endocytic Components
    Role: Principal Investigator
    R01CA129626     (BENOVIC, JEFFREY L)Jul 11, 2007 - May 31, 2013
    NIH
    Regulation of CXCR4 Signaling
    Role: Principal Investigator
    T32GM100836     (BENOVIC, JEFFREY L)Jul 1, 2012 - Dec 31, 2017
    NIH
    Training Program in Cellular, Biochemical, and Molecular Sciences
    Role: Principal Investigator
    R01HL136219     (BENOVIC, JEFFREY L)Jan 9, 2017 - Dec 31, 2020
    NIH
    Characterization of beta-arrestin-biased beta 2-adrenergic receptor signaling in cardiovascular function
    Role: Principal Investigator
    R35GM122541     (BENOVIC, JEFFREY L)Aug 1, 2017 - Jul 31, 2022
    NIH
    Regulation of G protein-coupled receptor signaling and trafficking
    Role: Principal Investigator
    R01HL142310     (BENOVIC, JEFFREY L)Apr 1, 2018 - Mar 31, 2022
    NIH
    Structural and dynamic analysis of GRK interaction with G protein-coupled receptors
    Role: Principal Investigator
    T32GM144302     (MERRY, DIANE E)Jul 1, 2022 - Jun 30, 2027
    NIH
    Training Grant in Cellular, Biochemical and Molecular Sciences
    Role: Co-Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. De Pascali F, Inoue A, Benovic JL. Diverse pathways in GPCR-mediated activation of Ca2+ mobilization in HEK293 cells. J Biol Chem. 2024 Oct 10; 107882. PMID: 39395798.
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    2. Varney MJ, Benovic JL. The Role of G Protein-Coupled Receptors and Receptor Kinases in Pancreatic ?-Cell Function and Diabetes. Pharmacol Rev. 2024 Feb 13; 76(2):267-299. PMID: 38351071.
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    3. Lefkowitz RJ, Rockman HA, Shim PJ, Liu S, Ahn S, Pani B, Rajagopal S, Shenoy SK, Bouvier M, Benovic JL, Liggett SB, Ruffolo RR, Bristow MR, Packer M. How carvedilol does not activate ?2-adrenoceptors. Nat Commun. 2023 Nov 30; 14(1):7866. PMID: 38036531.
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    4. Baqai U, Kurimchak AM, Trachtenberg I, Purwin TJ, Haj JI, Han A, Luo K, Pachon NF, Jeon A, Chua V, Davies MA, Gutkind JS, Benovic JL, Duncan JS, Aplin AE. Kinome profiling identifies MARK3 and STK10 as potential therapeutic targets in uveal melanoma. J Biol Chem. 2023 Nov 01; 105418. PMID: 37923138.
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    5. Ippolito M, De Pascali F, Hopfinger N, Komolov KE, Laurinavichyute D, Reddy PAN, Sakkal LA, Rajkowski KZ, Nayak AP, Lee J, Lee J, Cao G, Donover PS, Reichman M, An SS, Salvino JM, Penn RB, Armen RS, Scott CP, Benovic JL. Identification of a ?-arrestin-biased negative allosteric modulator for the ?2-adrenergic receptor. Proc Natl Acad Sci U S A. 2023 08; 120(31):e2302668120. PMID: 37490535.
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    6. Lapadula D, Lam B, Terai M, Sugase T, Tanaka R, Farias E, Kadamb R, Lopez-Anton M, Heine CC, Modasia B, Aguirre-Ghiso JA, Aplin AE, Sato T, Benovic JL. IGF1R Inhibition Enhances the Therapeutic Effects of Gq/11 Inhibition in Metastatic Uveal Melanoma Progression. Mol Cancer Ther. 2023 01 03; 22(1):63-74. PMID: 36223548.
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    7. Tompkins E, Mimic B, Cuevas-Mora K, Schorsch H, Shah SD, Deshpande DA, Benovic JL, Penn RB, Pera T. PD 102807 Induces M3 mAChR-Dependent GRK-/Arrestin-Biased Signaling in Airway Smooth Muscle Cells. Am J Respir Cell Mol Biol. 2022 11; 67(5):550-561. PMID: 35944139.
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    8. Varney MJ, Steyaert W, Coucke PJ, Delanghe JR, Uehling DE, Joseph B, Marcellus R, Al-Awar R, Benovic JL. G protein-coupled receptor kinase 6 (GRK6) regulates insulin processing and secretion via effects on proinsulin conversion to insulin. J Biol Chem. 2022 10; 298(10):102421. PMID: 36030052.
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    9. De Pascali F, Ippolito M, Wolfe E, Komolov KE, Hopfinger N, Lemenze D, Kim N, Armen RS, An SS, Scott CP, Benovic JL. ß-agonist profiling reveals biased signalling phenotypes for the ß2 -adrenergic receptor with possible implications for the treatment of asthma. Br J Pharmacol. 2022 Jun 22. PMID: 35732075.
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    10. Steyaert W, Varney MJ, Benovic JL, Creemers J, Speeckaert MM, Coucke PJ, Delanghe JR. Hypergastrinemia, a clue leading to the identification of an atypical form of diabetes mellitus type 2. Clin Chim Acta. 2022 May 24. PMID: 35623402.
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    11. Okyere AD, Song J, Patwa V, Carter RL, Enjamuri N, Lucchese AM, Ibetti J, de Lucia C, Schumacher SM, Koch WJ, Cheung JY, Benovic JL, Tilley DG. Pepducin ICL1-9-Mediated ß2-Adrenergic Receptor-Dependent Cardiomyocyte Contractility Occurs in a Gi Protein/ROCK/PKD-Sensitive Manner. Cardiovasc Drugs Ther. 2022 Jan 08. PMID: 34997361.
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    12. Luo J, De Pascali F, Richmond GW, Khojah AM, Benovic JL. Characterization of a new WHIM syndrome mutant reveals mechanistic differences in regulation of the chemokine receptor CXCR4. J Biol Chem. 2022 Feb; 298(2):101551. PMID: 34973340.
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    13. Lapadula D, Benovic JL. Targeting Oncogenic Gaq/11 in Uveal Melanoma. Cancers (Basel). 2021 Dec 09; 13(24). PMID: 34944815.
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    14. Ippolito M, De Pascali F, Inoue A, Benovic JL. Phenylalanine 193 in Extracellular Loop 2 of the ß2-Adrenergic Receptor Coordinates ß-Arrestin Interaction. Mol Pharmacol. 2022 02; 101(2):87-94. PMID: 34853152.
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    15. Terai M, Shimada A, Chervoneva I, Hulse L, Danielson M, Swensen J, Orloff M, Wedegaertner PB, Benovic JL, Aplin AE, Sato T. Prognostic Values of G-Protein Mutations in Metastatic Uveal Melanoma. Cancers (Basel). 2021 Nov 17; 13(22). PMID: 34830903.
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    16. Benovic JL. Historical Perspective of the G Protein-Coupled Receptor Kinase Family. Cells. 2021 Mar 04; 10(3). PMID: 33806476.
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    17. Ippolito M, Benovic JL. Biased agonism at ß-adrenergic receptors. Cell Signal. 2020 Dec 29; 80:109905. PMID: 33385503.
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    18. Komolov KE, Sulon SM, Bhardwaj A, van Keulen SC, Duc NM, Laurinavichyute DK, Lou HJ, Turk BE, Chung KY, Dror RO, Benovic JL. Structure of a GRK5-Calmodulin Complex Reveals Molecular Mechanism of GRK Activation and Substrate Targeting. Mol Cell. 2020 Dec 09. PMID: 33321095.
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    19. Sulon SM, Benovic JL. Targeting G protein-coupled receptor kinases (GRKs) to G protein-coupled receptors. Curr Opin Endocr Metab Res. 2021 Feb; 16:56-65. PMID: 33718657.
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    20. Yoo SM, Bhardwaj A, Benovic JL. Arresting Developments in Biased Signaling. Trends Pharmacol Sci. 2020 Apr 30. PMID: 32362341.
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    21. Chen X, Gupta S, Cooper M, DeHelian D, Zhao X, Naik MU, Wurtzel JGT, Stalker TJ, Goldfinger LE, Benovic J, Brass LF, McKenzie SE, Naik UP, Ma P. GRK6 regulates the hemostatic response to injury through its rate-limiting effects on GPCR signaling in platelets. Blood Adv. 2020 Jan 14; 4(1):76-86. PMID: 31899801.
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    22. Lagman J, Sayegh P, Lee CS, Sulon SM, Jacinto AZ, Sok V, Peng N, Alp D, Benovic JL, So CH. G protein-coupled receptor kinase 5 modifies cancer cell resistance to paclitaxel. Mol Cell Biochem. 2019 Jul 30. PMID: 31363957.
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    23. Lapadula D, Farias E, Randolph CE, Purwin T, McGrath D, Charpentier T, Zhang L, Wu S, Terai M, Sato T, Tall GG, Zhou N, Wedegaertner P, Aplin AE, Aguirre-Ghiso J, Benovic JL. Effects of Oncogenic Gaq and Ga11 Inhibition by FR900359 in Uveal Melanoma. Mol Cancer Res. 2018 Dec 19. PMID: 30567972.
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    24. Grisanti LA, Thomas TP, Carter RL, de Lucia C, Gao E, Koch WJ, Benovic JL, Tilley DG. Pepducin-mediated cardioprotection via ß-arrestin-biased ß2-adrenergic receptor-specific signaling. Theranostics. 2018; 8(17):4664-4678. PMID: 30279730.
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    25. Chaturvedi M, Schilling J, Beautrait A, Bouvier M, Benovic JL, Shukla AK. Emerging Paradigm of Intracellular Targeting of G Protein-Coupled Receptors. Trends Biochem Sci. 2018 Jul; 43(7):533-546. PMID: 29735399.
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    26. Panettieri RA, Pera T, Liggett SB, Benovic JL, Penn RB. Pepducins as a potential treatment strategy for asthma and COPD. Curr Opin Pharmacol. 2018 Jun; 40:120-125. PMID: 29729548.
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    27. Pera T, Deshpande DA, Ippolito M, Wang B, Gavrila A, Michael JV, Nayak AP, Tompkins E, Farrell E, Kroeze WK, Roth BL, Panettieri RA, Benovic JL, An SS, Dulin NO, Penn RB. Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines. FASEB J. 2018 Feb; 32(2):862-874. PMID: 29042451.
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    28. Komolov KE, Benovic JL. G protein-coupled receptor kinases: Past, present and future. Cell Signal. 2018 Jan; 41:17-24. PMID: 28711719.
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    29. Komolov KE, Du Y, Duc NM, Betz RM, Rodrigues JPGLM, Leib RD, Patra D, Skiniotis G, Adams CM, Dror RO, Chung KY, Kobilka BK, Benovic JL. Structural and Functional Analysis of a ß2-Adrenergic Receptor Complex with GRK5. Cell. 2017 Apr 20; 169(3):407-421.e16. PMID: 28431242.
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    30. Luo J, Busillo JM, Stumm R, Benovic JL. G Protein-Coupled Receptor Kinase 3 and Protein Kinase C Phosphorylate the Distal C-Terminal Tail of the Chemokine Receptor CXCR4 and Mediate Recruitment of ß-Arrestin. Mol Pharmacol. 2017 Jun; 91(6):554-566. PMID: 28331048.
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    31. Chua V, Lapadula D, Randolph C, Benovic JL, Wedegaertner PB, Aplin AE. Dysregulated GPCR Signaling and Therapeutic Options in Uveal Melanoma. Mol Cancer Res. 2017 May; 15(5):501-506. PMID: 28223438.
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    32. Wang J, Luo J, Aryal DK, Wetsel WC, Nass R, Benovic JL. G protein-coupled receptor kinase-2 (GRK-2) regulates serotonin metabolism through the monoamine oxidase AMX-2 in Caenorhabditis elegans. J Biol Chem. 2017 Apr 07; 292(14):5943-5956. PMID: 28213524.
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    33. DeRita RM, Zerlanko B, Singh A, Lu H, Iozzo RV, Benovic JL, Languino LR. c-Src, Insulin-Like Growth Factor I Receptor, G-Protein-Coupled Receptor Kinases and Focal Adhesion Kinase are Enriched Into Prostate Cancer Cell Exosomes. J Cell Biochem. 2017 Jan; 118(1):66-73. PMID: 27232975.
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    34. Carr R, Schilling J, Song J, Carter RL, Du Y, Yoo SM, Traynham CJ, Koch WJ, Cheung JY, Tilley DG, Benovic JL. ß-arrestin-biased signaling through the ß2-adrenergic receptor promotes cardiomyocyte contraction. Proc Natl Acad Sci U S A. 2016 Jul 12; 113(28):E4107-16. PMID: 27354517.
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    35. Tian X, Irannejad R, Bowman SL, Du Y, Puthenveedu MA, von Zastrow M, Benovic JL. The a-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the ß2-Adrenergic Receptor. J Biol Chem. 2016 Jul 8; 291(28):14510-25. PMID: 27226565.
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    36. Carr R, Benovic JL. From biased signalling to polypharmacology: unlocking unique intracellular signalling using pepducins. Biochem Soc Trans. 2016 Apr 15; 44(2):555-61. PMID: 27068969.
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    37. Carr R, Koziol-White C, Zhang J, Lam H, An SS, Tall GG, Panettieri RA, Benovic JL. Interdicting Gq Activation in Airway Disease by Receptor-Dependent and Receptor-Independent Mechanisms. Mol Pharmacol. 2016 Jan; 89(1):94-104. PMID: 26464325.
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    38. Benovic JL. Structural biology: Arresting developments in receptor signalling. Nature. 2015 Jul 30; 523(7562):538-9. PMID: 26200346.
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    39. Komolov KE, Bhardwaj A, Benovic JL. Atomic Structure of GRK5 Reveals Distinct Structural Features Novel for G Protein-coupled Receptor Kinases. J Biol Chem. 2015 Aug 21; 290(34):20629-47. PMID: 26032409.
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    40. Augello MA, Berman-Booty LD, Carr R, Yoshida A, Dean JL, Schiewer MJ, Feng FY, Tomlins SA, Gao E, Koch WJ, Benovic JL, Diehl JA, Knudsen KE. Consequence of the tumor-associated conversion to cyclin D1b. EMBO Mol Med. 2015; 7(5):628-47. PMID: 25787974.
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    41. Martinez-Martin N, Viejo-Borbolla A, Martín R, Blanco S, Benovic JL, Thelen M, Alcamí A. Herpes simplex virus enhances chemokine function through modulation of receptor trafficking and oligomerization. Nat Commun. 2015; 6:6163. PMID: 25625471.
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    42. Benovic JL, Armstrong RN. New frontiers in kinases. Biochemistry. 2015 Jan 13; 54(1):1. PMID: 25517407.
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    43. Carr R, Du Y, Quoyer J, Panettieri RA, Janz JM, Bouvier M, Kobilka BK, Benovic JL. Development and Characterization of Pepducins as Gs-biased Allosteric Agonists. J Biol Chem. 2014 Dec 26; 289(52):35668-84. PMID: 25395624.
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    44. Benovic JL, Armstrong RN. Call for Papers! A Special Thematic Compilation/Special Issue Crossover with ACS Chemical Biology, ACS Medicinal Chemistry Letters, and the Journal of Medicinal Chemistry Focused on New Frontiers in Kinases. Biochemistry. 2014 Mar 25; 53(11):1723. PMID: 24660987.
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    45. Benovic JL, von Zastrow M. Editorial overview: Cell regulation: The ins and outs of G protein-coupled receptors. Curr Opin Cell Biol. 2014 Apr; 27:v-vi. PMID: 24529749.
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    46. Tian X, Kang DS, Benovic JL. ß-Arrestins and G Protein-Coupled Receptor Trafficking. Handb Exp Pharmacol. 2014; 219:173-86. PMID: 24292830.
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    47. Kang DS, Tian X, Benovic JL. Role of ß-arrestins and arrestin domain-containing proteins in G protein-coupled receptor trafficking. Curr Opin Cell Biol. 2014 Apr; 27:63-71. PMID: 24680432.
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    48. Quoyer J, Janz JM, Luo J, Ren Y, Armando S, Lukashova V, Benovic JL, Carlson KE, Hunt SW, Bouvier M. Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein. Proc Natl Acad Sci U S A. 2013 Dec 24; 110(52):E5088-97. PMID: 24309376.
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    49. Kook S, Zhan X, Cleghorn WM, Benovic JL, Gurevich VV, Gurevich EV. Caspase-cleaved arrestin-2 and BID cooperatively facilitate cytochrome C release and cell death. Cell Death Differ. 2014 Jan; 21(1):172-84. PMID: 24141717.
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    50. So CH, Michal A, Komolov KE, Luo J, Benovic JL. G protein-coupled receptor kinase 2 (GRK2) is localized to centrosomes and mediates epidermal growth factor-promoted centrosomal separation. Mol Biol Cell. 2013 Sep; 24(18):2795-806. PMID: 23904266.
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    51. Kang DS, Tian X, Benovic JL. ß-Arrestins and G Protein-Coupled Receptor Trafficking. Methods Enzymol. 2013; 521:91-108. PMID: 23351735.
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    52. Chen YJ, Oldfield S, Butcher AJ, Tobin AB, Saxena K, Gurevich VV, Benovic JL, Henderson G, Kelly E. Identification of phosphorylation sites in the COOH-terminal tail of the µ-opioid receptor. J Neurochem. 2013 Jan; 124(2):189-99. PMID: 23106126.
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    53. Benovic JL. G-protein-coupled receptors signal victory. Cell. 2012 Dec 7; 151(6):1148-50. PMID: 23201142.
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    54. Li G, Zhou Q, Yu Y, Chen L, Shi Y, Luo J, Benovic J, Lu J, Zhou N. Identification and characterization of distinct C-terminal domains of the human hydroxycarboxylic Acid receptor-2 that are essential for receptor export, constitutive activity, desensitization, and internalization. Mol Pharmacol. 2012 Dec; 82(6):1150-61. PMID: 22962331.
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    55. So CH, Michal AM, Mashayekhi R, Benovic JL. G protein-coupled receptor kinase 5 phosphorylates nucleophosmin and regulates cell sensitivity to polo-like kinase 1 inhibition. J Biol Chem. 2012 May 18; 287(21):17088-99. PMID: 22467873.
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    56. Wood JF, Wang J, Benovic JL, Ferkey DM. Structural domains required for Caenorhabditis elegans G protein-coupled receptor kinase 2 (GRK-2) function in vivo. J Biol Chem. 2012 Apr 13; 287(16):12634-44. PMID: 22375004.
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    57. Michal AM, So CH, Beeharry N, Shankar H, Mashayekhi R, Yen TJ, Benovic JL. G Protein-coupled receptor kinase 5 is localized to centrosomes and regulates cell cycle progression. J Biol Chem. 2012 Feb 24; 287(9):6928-40. PMID: 22223642.
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    58. Woerner BM, Luo J, Brown KR, Jackson E, Dahiya SM, Mischel P, Benovic JL, Piwnica-Worms D, Rubin JB. Suppression of G-protein-coupled receptor kinase 3 expression is a feature of classical GBM that is required for maximal growth. Mol Cancer Res. 2012 Jan; 10(1):156-66. PMID: 22086906.
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    59. Bychkov ER, Ahmed MR, Gurevich VV, Benovic JL, Gurevich EV. Reduced expression of G protein-coupled receptor kinases in schizophrenia but not in schizoaffective disorder. Neurobiol Dis. 2011 Nov; 44(2):248-58. PMID: 21784156.
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    60. Barker BL, Benovic JL. G protein-coupled receptor kinase 5 phosphorylation of hip regulates internalization of the chemokine receptor CXCR4. Biochemistry. 2011 Aug 16; 50(32):6933-41. PMID: 21728385.
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    61. Michal AM, Peck AR, Tran TH, Liu C, Rimm DL, Rui H, Benovic JL. Differential expression of arrestins is a predictor of breast cancer progression and survival. Breast Cancer Res Treat. 2011 Dec; 130(3):791-807. PMID: 21318602.
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    62. Sosa MS, Lopez-Haber C, Yang C, Wang H, Lemmon MA, Busillo JM, Luo J, Benovic JL, Klein-Szanto A, Yagi H, Gutkind JS, Parsons RE, Kazanietz MG. Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer. Mol Cell. 2010 Dec 22; 40(6):877-92. PMID: 21172654.
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    63. Huang H, He X, Deng X, Li G, Ying G, Sun Y, Shi L, Benovic JL, Zhou N. Bombyx adipokinetic hormone receptor activates extracellular signal-regulated kinase 1 and 2 via G protein-dependent PKA and PKC but ß-arrestin-independent pathways. Biochemistry. 2010 Dec 28; 49(51):10862-72. PMID: 21126059.
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    64. Chen XP, Yang W, Fan Y, Luo JS, Hong K, Wang Z, Yan JF, Chen X, Lu JX, Benovic JL, Zhou NM. Structural determinants in the second intracellular loop of the human cannabinoid CB1 receptor mediate selective coupling to G(s) and G(i). Br J Pharmacol. 2010 Dec; 161(8):1817-34. PMID: 20735408.
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    65. Li G, Shi Y, Huang H, Zhang Y, Wu K, Luo J, Sun Y, Lu J, Benovic JL, Zhou N. Internalization of the human nicotinic acid receptor GPR109A is regulated by G(i), GRK2, and arrestin3. J Biol Chem. 2010 Jul 16; 285(29):22605-18. PMID: 20460384.
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    66. Palmitessa A, Benovic JL. Arrestin and the multi-PDZ domain-containing protein MPZ-1 interact with phosphatase and tensin homolog (PTEN) and regulate Caenorhabditis elegans longevity. J Biol Chem. 2010 May 14; 285(20):15187-200. PMID: 20207731.
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    67. Mundell SJ, Matharu AL, Nisar S, Palmer TM, Benovic JL, Kelly E. Deletion of the distal COOH-terminus of the A2B adenosine receptor switches internalization to an arrestin- and clathrin-independent pathway and inhibits recycling. Br J Pharmacol. 2010 Feb 01; 159(3):518-33. PMID: 20128803.
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    68. Shankar H, Michal A, Kern RC, Kang DS, Gurevich VV, Benovic JL. Non-visual arrestins are constitutively associated with the centrosome and regulate centrosome function. J Biol Chem. 2010 Mar 12; 285(11):8316-29. PMID: 20056609.
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    69. Busillo JM, Armando S, Sengupta R, Meucci O, Bouvier M, Benovic JL. Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling. J Biol Chem. 2010 Mar 5; 285(10):7805-17. PMID: 20048153.
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    70. Patial S, Luo J, Porter KJ, Benovic JL, Parameswaran N. G-protein-coupled-receptor kinases mediate TNFa-induced NF?B signalling via direct interaction with and phosphorylation of I?Ba. Biochem J. 2010 Jan 1; 425(1):169-78. PMID: 19796012.
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    71. Kang DS, Kern RC, Puthenveedu MA, von Zastrow M, Williams JC, Benovic JL. Structure of an arrestin2-clathrin complex reveals a novel clathrin binding domain that modulates receptor trafficking. J Biol Chem. 2009 Oct 23; 284(43):29860-72. PMID: 19710023.
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    72. Barthet G, Carrat G, Cassier E, Barker B, Gaven F, Pillot M, Framery B, Pellissier LP, Augier J, Kang DS, Claeysen S, Reiter E, Banères JL, Benovic JL, Marin P, Bockaert J, Dumuis A. Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling. EMBO J. 2009 Sep 16; 28(18):2706-18. PMID: 19661922.
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    73. Kern RC, Kang DS, Benovic JL. Arrestin2/clathrin interaction is regulated by key N- and C-terminal regions in arrestin2. Biochemistry. 2009 Aug 4; 48(30):7190-200. PMID: 19555118.
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    74. Pao CS, Barker BL, Benovic JL. Role of the amino terminus of G protein-coupled receptor kinase 2 in receptor phosphorylation. Biochemistry. 2009 Aug 4; 48(30):7325-33. PMID: 19715378.
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    75. Lakshmikanthan V, Zou L, Kim JI, Michal A, Nie Z, Messias NC, Benovic JL, Daaka Y. Identification of betaArrestin2 as a corepressor of androgen receptor signaling in prostate cancer. Proc Natl Acad Sci U S A. 2009 Jun 9; 106(23):9379-84. PMID: 19458261.
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    76. Zhu C, Huang H, Hua R, Li G, Yang D, Luo J, Zhang C, Shi L, Benovic JL, Zhou N. Molecular and functional characterization of adipokinetic hormone receptor and its peptide ligands in Bombyx mori. FEBS Lett. 2009 May 6; 583(9):1463-8. PMID: 19345219.
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    77. Yang M, He RL, Benovic JL, Ye RD. beta-Arrestin1 interacts with the G-protein subunits beta1gamma2 and promotes beta1gamma2-dependent Akt signalling for NF-kappaB activation. Biochem J. 2009 Jan 1; 417(1):287-96. PMID: 18729826.
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    78. Luo J, Busillo JM, Benovic JL. M3 muscarinic acetylcholine receptor-mediated signaling is regulated by distinct mechanisms. Mol Pharmacol. 2008 Aug; 74(2):338-47. PMID: 18388243.
      Citations:    
    79. Ahmed MR, Gurevich VV, Dalby KN, Benovic JL, Gurevich EV. Haloperidol and clozapine differentially affect the expression of arrestins, receptor kinases, and extracellular signal-regulated kinase activation. J Pharmacol Exp Ther. 2008 Apr; 325(1):276-83. PMID: 18178904.
      Citations:    
    80. Penn RB, Benovic JL. Regulation of heterotrimeric G protein signaling in airway smooth muscle. Proc Am Thorac Soc. 2008 Jan 1; 5(1):47-57. PMID: 18094084.
      Citations:    
    81. Ahmed MR, Bychkov E, Gurevich VV, Benovic JL, Gurevich EV. Altered expression and subcellular distribution of GRK subtypes in the dopamine-depleted rat basal ganglia is not normalized by l-DOPA treatment. J Neurochem. 2008 Mar; 104(6):1622-36. PMID: 17996024.
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    82. Bhandari D, Trejo J, Benovic JL, Marchese A. Arrestin-2 interacts with the ubiquitin-protein isopeptide ligase atrophin-interacting protein 4 and mediates endosomal sorting of the chemokine receptor CXCR4. J Biol Chem. 2007 Dec 21; 282(51):36971-9. PMID: 17947233.
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    83. Jiang X, Benovic JL, Wedegaertner PB. Plasma membrane and nuclear localization of G protein coupled receptor kinase 6A. Mol Biol Cell. 2007 Aug; 18(8):2960-9. PMID: 17538017.
      Citations:    
    84. Moore CA, Milano SK, Benovic JL. Regulation of receptor trafficking by GRKs and arrestins. Annu Rev Physiol. 2007; 69:451-82. PMID: 17037978.
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    85. Bychkov ER, Gurevich VV, Joyce JN, Benovic JL, Gurevich EV. Arrestins and two receptor kinases are upregulated in Parkinson's disease with dementia. Neurobiol Aging. 2008 Mar; 29(3):379-96. PMID: 17125886.
      Citations:    
    86. Busillo JM, Benovic JL. Regulation of CXCR4 signaling. Biochim Biophys Acta. 2007 Apr; 1768(4):952-63. PMID: 17169327.
      Citations:    
    87. Parameswaran N, Pao CS, Leonhard KS, Kang DS, Kratz M, Ley SC, Benovic JL. Arrestin-2 and G protein-coupled receptor kinase 5 interact with NFkappaB1 p105 and negatively regulate lipopolysaccharide-stimulated ERK1/2 activation in macrophages. J Biol Chem. 2006 Nov 10; 281(45):34159-70. PMID: 16980301.
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    88. Mundell SJ, Luo J, Benovic JL, Conley PB, Poole AW. Distinct clathrin-coated pits sort different G protein-coupled receptor cargo. Traffic. 2006 Oct; 7(10):1420-31. PMID: 16899088.
      Citations:    
    89. Lodowski DT, Tesmer VM, Benovic JL, Tesmer JJ. The structure of G protein-coupled receptor kinase (GRK)-6 defines a second lineage of GRKs. J Biol Chem. 2006 Jun 16; 281(24):16785-93. PMID: 16613860.
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    90. Milano SK, Kim YM, Stefano FP, Benovic JL, Brenner C. Nonvisual arrestin oligomerization and cellular localization are regulated by inositol hexakisphosphate binding. J Biol Chem. 2006 Apr 7; 281(14):9812-23. PMID: 16439357.
      Citations:    
    91. Guigoni C, Aubert I, Li Q, Gurevich VV, Benovic JL, Ferry S, Mach U, Stark H, Leriche L, H?kansson K, Bioulac BH, Gross CE, Sokoloff P, Fisone G, Gurevich EV, Bloch B, Bezard E. Pathogenesis of levodopa-induced dyskinesia: focus on D1 and D3 dopamine receptors. Parkinsonism Relat Disord. 2005 Jun; 11 Suppl 1:S25-9. PMID: 15885624.
      Citations:    
    92. Palmitessa A, Hess HA, Bany IA, Kim YM, Koelle MR, Benovic JL. Caenorhabditus elegans arrestin regulates neural G protein signaling and olfactory adaptation and recovery. J Biol Chem. 2005 Jul 1; 280(26):24649-62. PMID: 15878875.
      Citations:    
    93. Bezard E, Gross CE, Qin L, Gurevich VV, Benovic JL, Gurevich EV. L-DOPA reverses the MPTP-induced elevation of the arrestin2 and GRK6 expression and enhanced ERK activation in monkey brain. Neurobiol Dis. 2005 Mar; 18(2):323-35. PMID: 15686961.
      Citations:    
    94. Hardy AR, Conley PB, Luo J, Benovic JL, Poole AW, Mundell SJ. P2Y1 and P2Y12 receptors for ADP desensitize by distinct kinase-dependent mechanisms. Blood. 2005 May 1; 105(9):3552-60. PMID: 15665114.
      Citations:    
    95. Pao CS, Benovic JL. Structure/function analysis of alpha2A-adrenergic receptor interaction with G protein-coupled receptor kinase 2. J Biol Chem. 2005 Mar 25; 280(12):11052-8. PMID: 15653687.
      Citations:    
    96. Rutherford C, Ord-Shrimpton FU, Sands WA, Pediani JD, Benovic JL, McGrath JC, Palmer TM. Phosphorylation-independent internalisation and desensitisation of the human sphingosine-1-phosphate receptor S1P3. Cell Signal. 2005 Aug; 17(8):997-1009. PMID: 15894172.
      Citations:    
    97. Naik S, Billington CK, Pascual RM, Deshpande DA, Stefano FP, Kohout TA, Eckman DM, Benovic JL, Penn RB. Regulation of cysteinyl leukotriene type 1 receptor internalization and signaling. J Biol Chem. 2005 Mar 11; 280(10):8722-32. PMID: 15590629.
      Citations:    
    98. Gurevich EV, Benovic JL, Gurevich VV. Arrestin2 expression selectively increases during neural differentiation. J Neurochem. 2004 Dec; 91(6):1404-16. PMID: 15584917.
      Citations:    
    99. Iwata K, Luo J, Penn RB, Benovic JL. Bimodal regulation of the human H1 histamine receptor by G protein-coupled receptor kinase 2. J Biol Chem. 2005 Jan 21; 280(3):2197-204. PMID: 15542600.
      Citations:    
    100. Benovic JL, Marchese A. A new key in breast cancer metastasis. Cancer Cell. 2004 Nov; 6(5):429-30. PMID: 15542424.
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    101. Day PW, Tesmer JJ, Sterne-Marr R, Freeman LC, Benovic JL, Wedegaertner PB. Characterization of the GRK2 binding site of Galphaq. J Biol Chem. 2004 Dec 17; 279(51):53643-52. PMID: 15471870.
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    102. Thiyagarajan MM, Stracquatanio RP, Pronin AN, Evanko DS, Benovic JL, Wedegaertner PB. A predicted amphipathic helix mediates plasma membrane localization of GRK5. J Biol Chem. 2004 Apr 23; 279(17):17989-95. PMID: 14976207.
      Citations:    
    103. Marchese A, Benovic JL. Ubiquitination of G-protein-coupled receptors. Methods Mol Biol. 2004; 259:299-305. PMID: 15250500.
      Citations:    
    104. Day PW, Wedegaertner PB, Benovic JL. Analysis of G-protein-coupled receptor kinase RGS homology domains. Methods Enzymol. 2004; 390:295-310. PMID: 15488185.
      Citations:    
    105. Gutierrez-Ford C, Levay K, Gomes AV, Perera EM, Som T, Kim YM, Benovic JL, Berkovitz GD, Slepak VZ. Characterization of tescalcin, a novel EF-hand protein with a single Ca2+-binding site: metal-binding properties, localization in tissues and cells, and effect on calcineurin. Biochemistry. 2003 Dec 16; 42(49):14553-65. PMID: 14661968.
      Citations:    
    106. Marchese A, Raiborg C, Santini F, Keen JH, Stenmark H, Benovic JL. The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4. Dev Cell. 2003 Nov; 5(5):709-22. PMID: 14602072.
      Citations:    
    107. Luo J, Benovic JL. G protein-coupled receptor kinase interaction with Hsp90 mediates kinase maturation. J Biol Chem. 2003 Dec 19; 278(51):50908-14. PMID: 14557268.
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    108. Vishnivetskiy SA, Hosey MM, Benovic JL, Gurevich VV. Mapping the arrestin-receptor interface. Structural elements responsible for receptor specificity of arrestin proteins. J Biol Chem. 2004 Jan 9; 279(2):1262-8. PMID: 14530255.
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    109. Noble B, Kallal LA, Pausch MH, Benovic JL. Development of a yeast bioassay to characterize G protein-coupled receptor kinases. Identification of an NH2-terminal region essential for receptor phosphorylation. J Biol Chem. 2003 Nov 28; 278(48):47466-76. PMID: 14507916.
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    110. Day PW, Carman CV, Sterne-Marr R, Benovic JL, Wedegaertner PB. Differential interaction of GRK2 with members of the G alpha q family. Biochemistry. 2003 Aug 5; 42(30):9176-84. PMID: 12885252.
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    111. Marchese A, Chen C, Kim YM, Benovic JL. The ins and outs of G protein-coupled receptor trafficking. Trends Biochem Sci. 2003 Jul; 28(7):369-76. PMID: 12878004.
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    112. Benovic JL. Novel beta2-adrenergic receptor signaling pathways. J Allergy Clin Immunol. 2002 Dec; 110(6 Suppl):S229-35. PMID: 12464929.
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    113. Sterne-Marr R, Tesmer JJ, Day PW, Stracquatanio RP, Cilente JA, O'Connor KE, Pronin AN, Benovic JL, Wedegaertner PB. G protein-coupled receptor Kinase 2/G alpha q/11 interaction. A novel surface on a regulator of G protein signaling homology domain for binding G alpha subunits. J Biol Chem. 2003 Feb 21; 278(8):6050-8. PMID: 12427730.
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    114. Pao CS, Benovic JL. Phosphorylation-independent desensitization of G protein-coupled receptors? Sci STKE. 2002 Oct 8; 2002(153):pe42. PMID: 12372852.
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    115. DeGraff JL, Gurevich VV, Benovic JL. The third intracellular loop of alpha 2-adrenergic receptors determines subtype specificity of arrestin interaction. J Biol Chem. 2002 Nov 8; 277(45):43247-52. PMID: 12205092.
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    116. Kim YM, Benovic JL. Differential roles of arrestin-2 interaction with clathrin and adaptor protein 2 in G protein-coupled receptor trafficking. J Biol Chem. 2002 Aug 23; 277(34):30760-8. PMID: 12070169.
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    117. Milano SK, Pace HC, Kim YM, Brenner C, Benovic JL. Scaffolding functions of arrestin-2 revealed by crystal structure and mutagenesis. Biochemistry. 2002 Mar 12; 41(10):3321-8. PMID: 11876640.
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    118. Kim YM, Barak LS, Caron MG, Benovic JL. Regulation of arrestin-3 phosphorylation by casein kinase II. J Biol Chem. 2002 May 10; 277(19):16837-46. PMID: 11877451.
      Citations:    
    119. Handley DA, Senanayake CH, Dutczak W, Benovic JL, Walle T, Penn RB, Wilkinson HS, Tanoury GJ, Andersson RG, Johansson F, Morley J. Biological actions of formoterol isomers. Pulm Pharmacol Ther. 2002; 15(2):135-45. PMID: 12090787.
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    120. Kallal L, Benovic JL. Fluorescence microscopy techniques for the study of G protein-coupled receptor trafficking. Methods Enzymol. 2002; 343:492-506. PMID: 11665588.
      Citations:    
    121. Pronin AN, Loudon RP, Benovic JL. Characterization of G protein-coupled receptor kinases. Methods Enzymol. 2002; 343:547-59. PMID: 11665591.
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    122. Mundell SJ, Orsini MJ, Benovic JL. Characterization of arrestin expression and function. Methods Enzymol. 2002; 343:600-11. PMID: 11665594.
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    123. Gurevich EV, Benovic JL, Gurevich VV. Arrestin2 and arrestin3 are differentially expressed in the rat brain during postnatal development. Neuroscience. 2002; 109(3):421-36. PMID: 11823056.
      Citations:    
    124. Marchese A, Benovic JL. Agonist-promoted ubiquitination of the G protein-coupled receptor CXCR4 mediates lysosomal sorting. J Biol Chem. 2001 Dec 07; 276(49):45509-12. PMID: 11641392.
      Citations:    
    125. Watterson KR, Johnston E, Chalmers C, Pronin A, Cook SJ, Benovic JL, Palmer TM. Dual regulation of EDG1/S1P(1) receptor phosphorylation and internalization by protein kinase C and G-protein-coupled receptor kinase 2. J Biol Chem. 2002 Feb 22; 277(8):5767-77. PMID: 11741892.
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    126. Gray JA, Sheffler DJ, Bhatnagar A, Woods JA, Hufeisen SJ, Benovic JL, Roth BL. Cell-type specific effects of endocytosis inhibitors on 5-hydroxytryptamine(2A) receptor desensitization and resensitization reveal an arrestin-, GRK2-, and GRK5-independent mode of regulation in human embryonic kidney 293 cells. Mol Pharmacol. 2001 Nov; 60(5):1020-30. PMID: 11641430.
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    127. Penn RB, Pascual RM, Kim YM, Mundell SJ, Krymskaya VP, Panettieri RA, Benovic JL. Arrestin specificity for G protein-coupled receptors in human airway smooth muscle. J Biol Chem. 2001 Aug 31; 276(35):32648-56. PMID: 11418617.
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    128. Matharu AL, Mundell SJ, Benovic JL, Kelly E. Rapid agonist-induced desensitization and internalization of the A(2B) adenosine receptor is mediated by a serine residue close to the COOH terminus. J Biol Chem. 2001 Aug 10; 276(32):30199-207. PMID: 11333255.
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    129. Doranz BJ, Filion LG, Diaz-Mitoma F, Sitar DS, Sahai J, Baribaud F, Orsini MJ, Benovic JL, Cameron W, Doms RW. Safe use of the CXCR4 inhibitor ALX40-4C in humans. AIDS Res Hum Retroviruses. 2001 Apr 10; 17(6):475-86. PMID: 11350661.
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    130. Mundell SJ, Olah ME, Panettieri RA, Benovic JL, Penn RB. Regulation of G protein-coupled receptor-adenylyl cyclase responsiveness in human airway smooth muscle by exogenous and autocrine adenosine. Am J Respir Cell Mol Biol. 2001 Feb; 24(2):155-63. PMID: 11159049.
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    131. Shui Z, Khan IA, Haga T, Benovic JL, Boyett MR. Control of the cardiac muscarinic K+ channel by beta-arrestin 2. J Biol Chem. 2001 Apr 13; 276(15):11691-7. PMID: 11152693.
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    132. Parent JL, Labrecque P, Driss Rochdi M, Benovic JL. Role of the differentially spliced carboxyl terminus in thromboxane A2 receptor trafficking: identification of a distinct motif for tonic internalization. J Biol Chem. 2001 Mar 09; 276(10):7079-85. PMID: 11112783.
      Citations:    
    133. Yu X, Zhang M, Kyker K, Patterson E, Benovic JL, Kem DC. Ischemic inactivation of G protein-coupled receptor kinase and altered desensitization of canine cardiac beta-adrenergic receptors. Circulation. 2000 Nov 14; 102(20):2535-40. PMID: 11076829.
      Citations:    
    134. Bhatnagar A, Willins DL, Gray JA, Woods J, Benovic JL, Roth BL. The dynamin-dependent, arrestin-independent internalization of 5-hydroxytryptamine 2A (5-HT2A) serotonin receptors reveals differential sorting of arrestins and 5-HT2A receptors during endocytosis. J Biol Chem. 2001 Mar 16; 276(11):8269-77. PMID: 11069907.
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    135. Mundell SJ, Matharu AL, Kelly E, Benovic JL. Arrestin isoforms dictate differential kinetics of A2B adenosine receptor trafficking. Biochemistry. 2000 Oct 24; 39(42):12828-36. PMID: 11041847.
      Citations:    
    136. Li JG, Benovic JL, Liu-Chen LY. Mechanisms of agonist-induced down-regulation of the human kappa-opioid receptor: internalization is required for down-regulation. Mol Pharmacol. 2000 Oct; 58(4):795-801. PMID: 10999950.
      Citations:    
    137. Krymskaya VP, Orsini MJ, Eszterhas AJ, Brodbeck KC, Benovic JL, Panettieri RA, Penn RB. Mechanisms of proliferation synergy by receptor tyrosine kinase and G protein-coupled receptor activation in human airway smooth muscle. Am J Respir Cell Mol Biol. 2000 Oct; 23(4):546-54. PMID: 11017921.
      Citations:    
    138. Aiyar N, Disa J, Dang K, Pronin AN, Benovic JL, Nambi P. Involvement of G protein-coupled receptor kinase-6 in desensitization of CGRP receptors. Eur J Pharmacol. 2000 Sep 01; 403(1-2):1-7. PMID: 10969137.
      Citations:    
    139. Pronin AN, Morris AJ, Surguchov A, Benovic JL. Synucleins are a novel class of substrates for G protein-coupled receptor kinases. J Biol Chem. 2000 Aug 25; 275(34):26515-22. PMID: 10852916.
      Citations:    
    140. Santini F, Penn RB, Gagnon AW, Benovic JL, Keen JH. Selective recruitment of arrestin-3 to clathrin coated pits upon stimulation of G protein-coupled receptors. J Cell Sci. 2000 Jul; 113 ( Pt 13):2463-70. PMID: 10852825.
      Citations:    
    141. Tiruppathi C, Yan W, Sandoval R, Naqvi T, Pronin AN, Benovic JL, Malik AB. G protein-coupled receptor kinase-5 regulates thrombin-activated signaling in endothelial cells. Proc Natl Acad Sci U S A. 2000 Jun 20; 97(13):7440-5. PMID: 10861009.
      Citations:    
    142. Kallal L, Benovic JL. Using green fluorescent proteins to study G-protein-coupled receptor localization and trafficking. Trends Pharmacol Sci. 2000 May; 21(5):175-80. PMID: 10785651.
      Citations:    
    143. Mundell SJ, Benovic JL. Selective regulation of endogenous G protein-coupled receptors by arrestins in HEK293 cells. J Biol Chem. 2000 Apr 28; 275(17):12900-8. PMID: 10777589.
      Citations:    
    144. Carman CV, Barak LS, Chen C, Liu-Chen LY, Onorato JJ, Kennedy SP, Caron MG, Benovic JL. Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2. J Biol Chem. 2000 Apr 07; 275(14):10443-52. PMID: 10744734.
      Citations:    
    145. Wu G, Bogatkevich GS, Mukhin YV, Benovic JL, Hildebrandt JD, Lanier SM. Identification of Gbetagamma binding sites in the third intracellular loop of the M(3)-muscarinic receptor and their role in receptor regulation. J Biol Chem. 2000 Mar 24; 275(12):9026-34. PMID: 10722752.
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    146. Penn RB, Pronin AN, Benovic JL. Regulation of G protein-coupled receptor kinases. Trends Cardiovasc Med. 2000 Feb; 10(2):81-9. PMID: 11150735.
      Citations:    
    147. Haeseleer F, Sokal I, Verlinde CL, Erdjument-Bromage H, Tempst P, Pronin AN, Benovic JL, Fariss RN, Palczewski K. Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin. J Biol Chem. 2000 Jan 14; 275(2):1247-60. PMID: 10625670.
      Citations:    
    148. Gurevich VV, Benovic JL. Arrestin: mutagenesis, expression, purification, and functional characterization. Methods Enzymol. 2000; 315:422-37. PMID: 10736718.
      Citations:    
    149. Gros R, Chorazyczewski J, Meek MD, Benovic JL, Ferguson SS, Feldman RD. G-Protein-coupled receptor kinase activity in hypertension : increased vascular and lymphocyte G-protein receptor kinase-2 protein expression. Hypertension. 2000 Jan; 35(1 Pt 1):38-42. PMID: 10642272.
      Citations:    
    150. Eckhart AD, Duncan SJ, Penn RB, Benovic JL, Lefkowitz RJ, Koch WJ. Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart. Circ Res. 2000 Jan 7-21; 86(1):43-50. PMID: 10625304.
      Citations:    
    151. Carman CV, Parent JL, Day PW, Pronin AN, Sternweis PM, Wedegaertner PB, Gilman AG, Benovic JL, Kozasa T. Selective regulation of Galpha(q/11) by an RGS domain in the G protein-coupled receptor kinase, GRK2. J Biol Chem. 1999 Nov 26; 274(48):34483-92. PMID: 10567430.
      Citations:    
    152. Willets JM, Parent JL, Benovic JL, Kelly E. Selective reduction in A2 adenosine receptor desensitization following antisense-induced suppression of G protein-coupled receptor kinase 2 expression. J Neurochem. 1999 Nov; 73(5):1781-9. PMID: 10537035.
      Citations:    
    153. Billington CK, Hall IP, Mundell SJ, Parent JL, Panettieri RA, Benovic JL, Penn RB. Inflammatory and contractile agents sensitize specific adenylyl cyclase isoforms in human airway smooth muscle. Am J Respir Cell Mol Biol. 1999 Nov; 21(5):597-606. PMID: 10536119.
      Citations:    
    154. Orsini MJ, Parent JL, Mundell SJ, Marchese A, Benovic JL. Trafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the c-terminal tail that mediate receptor internalization. J Biol Chem. 1999 Oct 22; 274(43):31076-86. PMID: 10521508.
      Citations:    
    155. Orsini MJ, Krymskaya VP, Eszterhas AJ, Benovic JL, Panettieri RA, Penn RB. MAPK superfamily activation in human airway smooth muscle: mitogenesis requires prolonged p42/p44 activation. Am J Physiol. 1999 09; 277(3):L479-88. PMID: 10484455.
      Citations:    
    156. Mundell SJ, Loudon RP, Benovic JL. Characterization of G protein-coupled receptor regulation in antisense mRNA-expressing cells with reduced arrestin levels. Biochemistry. 1999 Jul 06; 38(27):8723-32. PMID: 10393547.
      Citations:    
    157. Lazari MF, Liu X, Nakamura K, Benovic JL, Ascoli M. Role of G protein-coupled receptor kinases on the agonist-induced phosphorylation and internalization of the follitropin receptor. Mol Endocrinol. 1999 Jun; 13(6):866-78. PMID: 10379886.
      Citations:    
    158. Wang YX, Dhulipala PD, Li L, Benovic JL, Kotlikoff MI. Coupling of M2 muscarinic receptors to membrane ion channels via phosphoinositide 3-kinase gamma and atypical protein kinase C. J Biol Chem. 1999 May 14; 274(20):13859-64. PMID: 10318793.
      Citations:    
    159. Gros R, Tan CM, Chorazyczewski J, Kelvin DJ, Benovic JL, Feldman RD. G-protein-coupled receptor kinase expression in hypertension. Clin Pharmacol Ther. 1999 May; 65(5):545-51. PMID: 10340920.
      Citations:    
    160. Gelber EI, Kroeze WK, Willins DL, Gray JA, Sinar CA, Hyde EG, Gurevich V, Benovic J, Roth BL. Structure and function of the third intracellular loop of the 5-hydroxytryptamine2A receptor: the third intracellular loop is alpha-helical and binds purified arrestins. J Neurochem. 1999 May; 72(5):2206-14. PMID: 10217304.
      Citations:    
    161. Li JG, Luo LY, Krupnick JG, Benovic JL, Liu-Chen LY. U50,488H-induced internalization of the human kappa opioid receptor involves a beta-arrestin- and dynamin-dependent mechanism. Kappa receptor internalization is not required for mitogen-activated protein kinase activation. J Biol Chem. 1999 Apr 23; 274(17):12087-94. PMID: 10207034.
      Citations:    
    162. DeGraff JL, Gagnon AW, Benovic JL, Orsini MJ. Role of arrestins in endocytosis and signaling of alpha2-adrenergic receptor subtypes. J Biol Chem. 1999 Apr 16; 274(16):11253-9. PMID: 10196213.
      Citations:    
    163. Parent JL, Labrecque P, Orsini MJ, Benovic JL. Internalization of the TXA2 receptor alpha and beta isoforms. Role of the differentially spliced cooh terminus in agonist-promoted receptor internalization. J Biol Chem. 1999 Mar 26; 274(13):8941-8. PMID: 10085139.
      Citations:    
    164. Carman CV, Lisanti MP, Benovic JL. Regulation of G protein-coupled receptor kinases by caveolin. J Biol Chem. 1999 Mar 26; 274(13):8858-64. PMID: 10085129.
      Citations:    
    165. Gaidarov I, Krupnick JG, Falck JR, Benovic JL, Keen JH. Arrestin function in G protein-coupled receptor endocytosis requires phosphoinositide binding. EMBO J. 1999 Feb 15; 18(4):871-81. PMID: 10022830.
      Citations:    
    166. Penn RB, Parent JL, Pronin AN, Panettieri RA, Benovic JL. Pharmacological inhibition of protein kinases in intact cells: antagonism of beta adrenergic receptor ligand binding by H-89 reveals limitations of usefulness. J Pharmacol Exp Ther. 1999 Feb; 288(2):428-37. PMID: 9918542.
      Citations:    
    167. Mukherjee S, Palczewski K, Gurevich V, Benovic JL, Banga JP, Hunzicker-Dunn M. A direct role for arrestins in desensitization of the luteinizing hormone/choriogonadotropin receptor in porcine ovarian follicular membranes. Proc Natl Acad Sci U S A. 1999 Jan 19; 96(2):493-8. PMID: 9892661.
      Citations:    
    168. Hosey MM, Pals-Rylaarsdam R, Lee KB, Roseberry AG, Benovic JL, Gurevich VV, B?nemann M. Molecular events associated with the regulation of signaling by M2 muscarinic receptors. Life Sci. 1999; 64(6-7):363-8. PMID: 10069497.
      Citations:    
    169. Orsini MJ, Benovic JL. Characterization of dominant negative arrestins that inhibit beta2-adrenergic receptor internalization by distinct mechanisms. J Biol Chem. 1998 Dec 18; 273(51):34616-22. PMID: 9852134.
      Citations:    
    170. Pronin AN, Carman CV, Benovic JL. Structure-function analysis of G protein-coupled receptor kinase-5. Role of the carboxyl terminus in kinase regulation. J Biol Chem. 1998 Nov 20; 273(47):31510-8. PMID: 9813065.
      Citations:    
    171. Levay K, Satpaev DK, Pronin AN, Benovic JL, Slepak VZ. Localization of the sites for Ca2+-binding proteins on G protein-coupled receptor kinases. Biochemistry. 1998 Sep 29; 37(39):13650-9. PMID: 9753452.
      Citations:    
    172. Nakamura K, Krupnick JG, Benovic JL, Ascoli M. Signaling and phosphorylation-impaired mutants of the rat follitropin receptor reveal an activation- and phosphorylation-independent but arrestin-dependent pathway for internalization. J Biol Chem. 1998 Sep 18; 273(38):24346-54. PMID: 9733722.
      Citations:    
    173. Mundell SJ, Luty JS, Willets J, Benovic JL, Kelly E. Enhanced expression of G protein-coupled receptor kinase 2 selectively increases the sensitivity of A2A adenosine receptors to agonist-induced desensitization. Br J Pharmacol. 1998 Sep; 125(2):347-56. PMID: 9786508.
      Citations:    
    174. Carman CV, Som T, Kim CM, Benovic JL. Binding and phosphorylation of tubulin by G protein-coupled receptor kinases. J Biol Chem. 1998 Aug 07; 273(32):20308-16. PMID: 9685381.
      Citations:    
    175. Penn RB, Panettieri RA, Benovic JL. Mechanisms of acute desensitization of the beta2AR-adenylyl cyclase pathway in human airway smooth muscle. Am J Respir Cell Mol Biol. 1998 Aug; 19(2):338-48. PMID: 9698608.
      Citations:    
    176. Lazari MF, Bertrand JE, Nakamura K, Liu X, Krupnick JG, Benovic JL, Ascoli M. Mutation of individual serine residues in the C-terminal tail of the lutropin/choriogonadotropin receptor reveal distinct structural requirements for agonist-induced uncoupling and agonist-induced internalization. J Biol Chem. 1998 Jul 17; 273(29):18316-24. PMID: 9660797.
      Citations:    
    177. Carman CV, Benovic JL. G-protein-coupled receptors: turn-ons and turn-offs. Curr Opin Neurobiol. 1998 Jun; 8(3):335-44. PMID: 9687355.
      Citations:    
    178. Lee KB, Pals-Rylaarsdam R, Benovic JL, Hosey MM. Arrestin-independent internalization of the m1, m3, and m4 subtypes of muscarinic cholinergic receptors. J Biol Chem. 1998 May 22; 273(21):12967-72. PMID: 9582330.
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    179. Wu G, Benovic JL, Hildebrandt JD, Lanier SM. Receptor docking sites for G-protein betagamma subunits. Implications for signal regulation. J Biol Chem. 1998 Mar 27; 273(13):7197-200. PMID: 9516410.
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    180. Gagnon AW, Kallal L, Benovic JL. Role of clathrin-mediated endocytosis in agonist-induced down-regulation of the beta2-adrenergic receptor. J Biol Chem. 1998 Mar 20; 273(12):6976-81. PMID: 9507004.
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    181. Kallal L, Gagnon AW, Penn RB, Benovic JL. Visualization of agonist-induced sequestration and down-regulation of a green fluorescent protein-tagged beta2-adrenergic receptor. J Biol Chem. 1998 Jan 02; 273(1):322-8. PMID: 9417083.
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    182. Krupnick JG, Benovic JL. The role of receptor kinases and arrestins in G protein-coupled receptor regulation. Annu Rev Pharmacol Toxicol. 1998; 38:289-319. PMID: 9597157.
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    183. Goodman OB, Krupnick JG, Santini F, Gurevich VV, Penn RB, Gagnon AW, Keen JH, Benovic JL. Role of arrestins in G-protein-coupled receptor endocytosis. Adv Pharmacol. 1998; 42:429-33. PMID: 9327931.
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    184. Krupnick JG, Santini F, Gagnon AW, Keen JH, Benovic JL. Modulation of the arrestin-clathrin interaction in cells. Characterization of beta-arrestin dominant-negative mutants. J Biol Chem. 1997 Dec 19; 272(51):32507-12. PMID: 9405462.
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    185. Gurevich VV, Pals-Rylaarsdam R, Benovic JL, Hosey MM, Onorato JJ. Agonist-receptor-arrestin, an alternative ternary complex with high agonist affinity. J Biol Chem. 1997 Nov 14; 272(46):28849-52. PMID: 9360951.
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    186. Loudon RP, Benovic JL. Altered activity of palmitoylation-deficient and isoprenylated forms of the G protein-coupled receptor kinase GRK6. J Biol Chem. 1997 Oct 24; 272(43):27422-7. PMID: 9341194.
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    187. Pals-Rylaarsdam R, Gurevich VV, Lee KB, Ptasienski JA, Benovic JL, Hosey MM. Internalization of the m2 muscarinic acetylcholine receptor. Arrestin-independent and -dependent pathways. J Biol Chem. 1997 Sep 19; 272(38):23682-9. PMID: 9295310.
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    188. Fukayama S, Kong G, Benovic JL, Meurer E, Tashjian AH. Beta-adrenergic receptor kinase-1 acutely regulates PTH/PTHrP receptor signalling in human osteoblastlike cells. Cell Signal. 1997 Sep; 9(6):469-74. PMID: 9376230.
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    189. Pronin AN, Satpaev DK, Slepak VZ, Benovic JL. Regulation of G protein-coupled receptor kinases by calmodulin and localization of the calmodulin binding domain. J Biol Chem. 1997 Jul 18; 272(29):18273-80. PMID: 9218466.
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    190. Krupnick JG, Gurevich VV, Benovic JL. Mechanism of quenching of phototransduction. Binding competition between arrestin and transducin for phosphorhodopsin. J Biol Chem. 1997 Jul 18; 272(29):18125-31. PMID: 9218446.
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    191. Wu G, Krupnick JG, Benovic JL, Lanier SM. Interaction of arrestins with intracellular domains of muscarinic and alpha2-adrenergic receptors. J Biol Chem. 1997 Jul 11; 272(28):17836-42. PMID: 9211939.
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    192. Gray-Keller MP, Detwiler PB, Benovic JL, Gurevich VV. Arrestin with a single amino acid substitution quenches light-activated rhodopsin in a phosphorylation-independent fashion. Biochemistry. 1997 Jun 10; 36(23):7058-63. PMID: 9188704.
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    193. Goodman OB, Krupnick JG, Gurevich VV, Benovic JL, Keen JH. Arrestin/clathrin interaction. Localization of the arrestin binding locus to the clathrin terminal domain. J Biol Chem. 1997 Jun 06; 272(23):15017-22. PMID: 9169477.
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    194. Krupnick JG, Goodman OB, Keen JH, Benovic JL. Arrestin/clathrin interaction. Localization of the clathrin binding domain of nonvisual arrestins to the carboxy terminus. J Biol Chem. 1997 Jun 06; 272(23):15011-6. PMID: 9169476.
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    195. Mundell SJ, Benovic JL, Kelly E. A dominant negative mutant of the G protein-coupled receptor kinase 2 selectively attenuates adenosine A2 receptor desensitization. Mol Pharmacol. 1997 Jun; 51(6):991-8. PMID: 9187265.
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    196. Kelsen SG, Anakwe OO, Aksoy MO, Reddy PJ, Dhanesekaran N, Penn R, Benovic JL. Chronic effects of catecholamines on the beta 2-adrenoreceptor system in cultured human airway epithelial cells. Am J Physiol. 1997 May; 272(5 Pt 1):L916-24. PMID: 9176257.
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    197. Gros R, Benovic JL, Tan CM, Feldman RD. G-protein-coupled receptor kinase activity is increased in hypertension. J Clin Invest. 1997 May 01; 99(9):2087-93. PMID: 9151780.
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    198. Pronin AN, Benovic JL. Regulation of the G protein-coupled receptor kinase GRK5 by protein kinase C. J Biol Chem. 1997 Feb 07; 272(6):3806-12. PMID: 9013639.
      Citations:    
    199. Gagnon AW, Benovic JL. Identification and chromosomal localization of a processed pseudogene of human GRK6. Gene. 1997 Jan 03; 184(1):13-9. PMID: 9016947.
      Citations:    
    200. Gurevich VV, Benovic JL. Mechanism of phosphorylation-recognition by visual arrestin and the transition of arrestin into a high affinity binding state. Mol Pharmacol. 1997 Jan; 51(1):161-9. PMID: 9016359.
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    201. Loudon RP, Perussia B, Benovic JL. Differentially regulated expression of the G-protein-coupled receptor kinases, betaARK and GRK6, during myelomonocytic cell development in vitro. Blood. 1996 Dec 15; 88(12):4547-57. PMID: 8977246.
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    202. Goodman OB, Krupnick JG, Santini F, Gurevich VV, Penn RB, Gagnon AW, Keen JH, Benovic JL. Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor. Nature. 1996 Oct 03; 383(6599):447-50. PMID: 8837779.
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    203. Penn RB, Shaver JR, Zangrilli JG, Pollice M, Fish JE, Peters SP, Benovic JL. Effects of inflammation and acute beta-agonist inhalation on beta 2-AR signaling in human airways. Am J Physiol. 1996 Oct; 271(4 Pt 1):L601-8. PMID: 8897908.
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    204. DebBurman SK, Ptasienski J, Benovic JL, Hosey MM. G protein-coupled receptor kinase GRK2 is a phospholipid-dependent enzyme that can be conditionally activated by G protein betagamma subunits. J Biol Chem. 1996 Sep 13; 271(37):22552-62. PMID: 8798423.
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    205. Palmer TM, Benovic JL, Stiles GL. Molecular basis for subtype-specific desensitization of inhibitory adenosine receptors. Analysis of a chimeric A1-A3 adenosine receptor. J Biol Chem. 1996 Jun 21; 271(25):15272-8. PMID: 8663009.
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    206. Diviani D, Lattion AL, Larbi N, Kunapuli P, Pronin A, Benovic JL, Cotecchia S. Effect of different G protein-coupled receptor kinases on phosphorylation and desensitization of the alpha1B-adrenergic receptor. J Biol Chem. 1996 Mar 01; 271(9):5049-58. PMID: 8617782.
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    207. Murga C, Ruiz-G?mez A, Garc?a-Higuera I, Kim CM, Benovic JL, Mayor F. High affinity binding of beta-adrenergic receptor kinase to microsomal membranes. Modulation of the activity of bound kinase by heterotrimeric G protein activation. J Biol Chem. 1996 Jan 12; 271(2):985-94. PMID: 8557715.
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    208. Penn RB, Frielle T, McCullough JR, Aberg G, Benovic JL. Comparison of R-, S-, and RS-albuterol interaction with human beta 1- and beta 2-adrenergic receptors. Clin Rev Allergy Immunol. 1996; 14(1):37-45. PMID: 8866170.
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    209. Hosey MM, DebBurman SK, Pals-Rylaarsdam R, Richardson RM, Benovic JL. The role of G-protein coupled receptor kinases in the regulation of muscarinic cholinergic receptors. Prog Brain Res. 1996; 109:169-79. PMID: 9009704.
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    210. Palmer TM, Benovic JL, Stiles GL. Agonist-dependent phosphorylation and desensitization of the rat A3 adenosine receptor. Evidence for a G-protein-coupled receptor kinase-mediated mechanism. J Biol Chem. 1995 Dec 08; 270(49):29607-13. PMID: 7494005.
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    211. Kelsen SG, Higgins NC, Zhou S, Mardini IA, Benovic JL. Expression and function of the beta-adrenergic receptor coupled-adenylyl cyclase system on human airway epithelial cells. Am J Respir Crit Care Med. 1995 Dec; 152(6 Pt 1):1774-83. PMID: 8520736.
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    212. Pals-Rylaarsdam R, Xu Y, Witt-Enderby P, Benovic JL, Hosey MM. Desensitization and internalization of the m2 muscarinic acetylcholine receptor are directed by independent mechanisms. J Biol Chem. 1995 Dec 01; 270(48):29004-11. PMID: 7499433.
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    213. Onorato JJ, Gillis ME, Liu Y, Benovic JL, Ruoho AE. The beta-adrenergic receptor kinase (GRK2) is regulated by phospholipids. J Biol Chem. 1995 Sep 08; 270(36):21346-53. PMID: 7673171.
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    214. Saito M, Frielle T, Benovic JL, Ledeen RW. Modulation by GM1 ganglioside of beta 1-adrenergic receptor-induced cyclic AMP formation in Sf9 cells. Biochim Biophys Acta. 1995 May 29; 1267(1):1-5. PMID: 7779864.
      Citations:    
    215. Zhang J, Zhang J, Benovic JL, Sugai M, Wetzker R, Gout I, Rittenhouse SE. Sequestration of a G-protein beta gamma subunit or ADP-ribosylation of Rho can inhibit thrombin-induced activation of platelet phosphoinositide 3-kinases. J Biol Chem. 1995 Mar 24; 270(12):6589-94. PMID: 7896797.
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    216. DebBurman SK, Ptasienski J, Boetticher E, Lomasney JW, Benovic JL, Hosey MM. Lipid-mediated regulation of G protein-coupled receptor kinases 2 and 3. J Biol Chem. 1995 Mar 17; 270(11):5742-7. PMID: 7890702.
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    217. Gurevich VV, Benovic JL. Visual arrestin binding to rhodopsin. Diverse functional roles of positively charged residues within the phosphorylation-recognition region of arrestin. J Biol Chem. 1995 Mar 17; 270(11):6010-6. PMID: 7890732.
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    218. Anakwe O, Zhou S, Benovic J, Aksoy M, Kelsen SG. Interleukins impair beta-adrenergic receptor adenylate cyclase (beta AR-AC) system function in human airway epithelial cells. Chest. 1995 Mar; 107(3 Suppl):138S-139S. PMID: 7874996.
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    219. Debburman SK, Kunapuli P, Benovic JL, Hosey MM. Agonist-dependent phosphorylation of human muscarinic receptors in Spodoptera frugiperda insect cell membranes by G protein-coupled receptor kinases. Mol Pharmacol. 1995 Feb; 47(2):224-33. PMID: 7870029.
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    220. Prossnitz ER, Kim CM, Benovic JL, Ye RD. Phosphorylation of the N-formyl peptide receptor carboxyl terminus by the G protein-coupled receptor kinase, GRK2. J Biol Chem. 1995 Jan 20; 270(3):1130-7. PMID: 7836371.
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    221. Gurevich VV, Dion SB, Onorato JJ, Ptasienski J, Kim CM, Sterne-Marr R, Hosey MM, Benovic JL. Arrestin interactions with G protein-coupled receptors. Direct binding studies of wild type and mutant arrestins with rhodopsin, beta 2-adrenergic, and m2 muscarinic cholinergic receptors. J Biol Chem. 1995 Jan 13; 270(2):720-31. PMID: 7822302.
      Citations:    
    222. Hosey MM, Benovic JL, DebBurman SK, Richardson RM. Multiple mechanisms involving protein phosphorylation are linked to desensitization of muscarinic receptors. Life Sci. 1995; 56(11-12):951-5. PMID: 10188798.
      Citations:    
    223. Sterne-Marr R, Benovic JL. Regulation of G protein-coupled receptors by receptor kinases and arrestins. Vitam Horm. 1995; 51:193-234. PMID: 7483322.
      Citations:    
    224. Penn RB, Kelsen SG, Benovic JL. Regulation of beta-agonist- and prostaglandin E2-mediated adenylyl cyclase activity in human airway epithelial cells. Am J Respir Cell Mol Biol. 1994 Oct; 11(4):496-505. PMID: 7917318.
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    225. Kelsen SG, Zhou S, Anakwe O, Mardini I, Higgins N, Benovic JL. Expression of the beta-adrenergic receptor-adenylylcyclase system in basal and columnar airway epithelial cells. Am J Physiol. 1994 Oct; 267(4 Pt 1):L456-63. PMID: 7943348.
      Citations:    
    226. Loudon RP, Benovic JL. Expression, purification, and characterization of the G protein-coupled receptor kinase GRK6. J Biol Chem. 1994 Sep 09; 269(36):22691-7. PMID: 8077221.
      Citations:    
    227. Mardini IA, Higgins NC, Zhou S, Benovic JL, Kelsen SG. Functional behavior of the beta-adrenergic receptor-adenylyl cyclase system in rabbit airway epithelium. Am J Respir Cell Mol Biol. 1994 Sep; 11(3):287-95. PMID: 7916196.
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    228. Raynor K, Kong H, Hines J, Kong G, Benovic J, Yasuda K, Bell GI, Reisine T. Molecular mechanisms of agonist-induced desensitization of the cloned mouse kappa opioid receptor. J Pharmacol Exp Ther. 1994 Sep; 270(3):1381-6. PMID: 7932192.
      Citations:    
    229. Penn RB, Benovic JL. Structure of the human gene encoding the beta-adrenergic receptor kinase. J Biol Chem. 1994 May 27; 269(21):14924-30. PMID: 8195124.
      Citations:    
    230. Kong G, Penn R, Benovic JL. A beta-adrenergic receptor kinase dominant negative mutant attenuates desensitization of the beta 2-adrenergic receptor. J Biol Chem. 1994 May 06; 269(18):13084-7. PMID: 8175732.
      Citations:    
    231. Kunapuli P, Gurevich VV, Benovic JL. Phospholipid-stimulated autophosphorylation activates the G protein-coupled receptor kinase GRK5. J Biol Chem. 1994 Apr 08; 269(14):10209-12. PMID: 8144599.
      Citations:    
    232. Gurevich VV, Chen CY, Kim CM, Benovic JL. Visual arrestin binding to rhodopsin. Intramolecular interaction between the basic N terminus and acidic C terminus of arrestin may regulate binding selectivity. J Biol Chem. 1994 Mar 25; 269(12):8721-7. PMID: 8132602.
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    233. Krupnick JG, Gurevich VV, Schepers T, Hamm HE, Benovic JL. Arrestin-rhodopsin interaction. Multi-site binding delineated by peptide inhibition. J Biol Chem. 1994 Feb 04; 269(5):3226-32. PMID: 8106358.
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    234. Garc?a-Higuera I, Penela P, Murga C, Egea G, Bonay P, Benovic JL, Mayor F. Association of the regulatory beta-adrenergic receptor kinase with rat liver microsomal membranes. J Biol Chem. 1994 Jan 14; 269(2):1348-55. PMID: 8288600.
      Citations:    
    235. Kunapuli P, Onorato JJ, Hosey MM, Benovic JL. Expression, purification, and characterization of the G protein-coupled receptor kinase GRK5. J Biol Chem. 1994 Jan 14; 269(2):1099-105. PMID: 8288567.
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    236. Ramkumar V, Kwatra M, Benovic JL, Stiles GL, Stilesa GL. Functional consequences of A1 adenosine-receptor phosphorylation by the beta-adrenergic receptor kinase. Biochim Biophys Acta. 1993 Oct 07; 1179(1):89-97. PMID: 8399355.
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    237. Benovic JL, Gomez J. Molecular cloning and expression of GRK6. A new member of the G protein-coupled receptor kinase family. J Biol Chem. 1993 Sep 15; 268(26):19521-7. PMID: 8366096.
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    238. Gurevich VV, Richardson RM, Kim CM, Hosey MM, Benovic JL. Binding of wild type and chimeric arrestins to the m2 muscarinic cholinergic receptor. J Biol Chem. 1993 Aug 15; 268(23):16879-82. PMID: 8349577.
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    239. Kim CM, Dion SB, Benovic JL. Mechanism of beta-adrenergic receptor kinase activation by G proteins. J Biol Chem. 1993 Jul 25; 268(21):15412-8. PMID: 8393441.
      Citations:    
    240. Sterne-Marr R, Gurevich VV, Goldsmith P, Bodine RC, Sanders C, Donoso LA, Benovic JL. Polypeptide variants of beta-arrestin and arrestin3. J Biol Chem. 1993 Jul 25; 268(21):15640-8. PMID: 8340388.
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    241. Richardson RM, Kim C, Benovic JL, Hosey MM. Phosphorylation and desensitization of human m2 muscarinic cholinergic receptors by two isoforms of the beta-adrenergic receptor kinase. J Biol Chem. 1993 Jun 25; 268(18):13650-6. PMID: 8514797.
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    242. Kunapuli P, Benovic JL. Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family. Proc Natl Acad Sci U S A. 1993 Jun 15; 90(12):5588-92. PMID: 7685906.
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    243. Gurevich VV, Benovic JL. Visual arrestin interaction with rhodopsin. Sequential multisite binding ensures strict selectivity toward light-activated phosphorylated rhodopsin. J Biol Chem. 1993 Jun 05; 268(16):11628-38. PMID: 8505295.
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    244. Kwatra MM, Schwinn DA, Schreurs J, Blank JL, Kim CM, Benovic JL, Krause JE, Caron MG, Lefkowitz RJ. The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2. J Biol Chem. 1993 May 05; 268(13):9161-4. PMID: 7683643.
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    245. Chen CY, Dion SB, Kim CM, Benovic JL. Beta-adrenergic receptor kinase. Agonist-dependent receptor binding promotes kinase activation. J Biol Chem. 1993 Apr 15; 268(11):7825-31. PMID: 8096517.
      Citations:    
    246. Kim CM, Dion SB, Onorato JJ, Benovic JL. Expression and characterization of two beta-adrenergic receptor kinase isoforms using the baculovirus expression system. Receptor. 1993; 3(1):39-55. PMID: 8394172.
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    247. Gurevich VV, Benovic JL. Cell-free expression of visual arrestin. Truncation mutagenesis identifies multiple domains involved in rhodopsin interaction. J Biol Chem. 1992 Oct 25; 267(30):21919-23. PMID: 1400502.
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    248. Pitcher JA, Inglese J, Higgins JB, Arriza JL, Casey PJ, Kim C, Benovic JL, Kwatra MM, Caron MG, Lefkowitz RJ. Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors. Science. 1992 Aug 28; 257(5074):1264-7. PMID: 1325672.
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    249. Kelsen SG, Mardini IA, Zhou S, Benovic JL, Higgins NC. A technique to harvest viable tracheobronchial epithelial cells from living human donors. Am J Respir Cell Mol Biol. 1992 Jul; 7(1):66-72. PMID: 1320903.
      Citations:    
    250. Gomez J, Benovic JL. Molecular and regulatory properties of the adenylyl cyclase-coupled beta-adrenergic receptors. Int Rev Cytol. 1992; 137B:1-34. PMID: 1336003.
      Citations:    
    251. Palczewski K, Benovic JL. G-protein-coupled receptor kinases. Trends Biochem Sci. 1991 Oct; 16(10):387-91. PMID: 1664548.
      Citations:    
    252. Yang SD, Benovic JL, Fong YL, Caron MG, Lefkowitz RJ. Cyclic phosphorylation-dephosphorylation of rhodopsin in retina by protein kinase FA (the activator of ATP.Mg-dependent protein phosphatase). Biochem Biophys Res Commun. 1991 Aug 15; 178(3):1306-11. PMID: 1651717.
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    253. Benovic JL, Onorato JJ, Arriza JL, Stone WC, Lohse M, Jenkins NA, Gilbert DJ, Copeland NG, Caron MG, Lefkowitz RJ. Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family. J Biol Chem. 1991 Aug 15; 266(23):14939-46. PMID: 1869533.
      Citations:    
    254. Onorato JJ, Palczewski K, Regan JW, Caron MG, Lefkowitz RJ, Benovic JL. Role of acidic amino acids in peptide substrates of the beta-adrenergic receptor kinase and rhodopsin kinase. Biochemistry. 1991 May 28; 30(21):5118-25. PMID: 1645191.
      Citations:    
    255. Benovic JL, Stone WC, Huebner K, Croce C, Caron MG, Lefkowitz RJ. cDNA cloning and chromosomal localization of the human beta-adrenergic receptor kinase. FEBS Lett. 1991 May 20; 283(1):122-6. PMID: 2037065.
      Citations:    
    256. Benovic JL. Purification and characterization of beta-adrenergic receptor kinase. Methods Enzymol. 1991; 200:351-62. PMID: 1659657.
      Citations:    
    257. Collins S, Bouvier M, Lohse MJ, Benovic JL, Caron MG, Lefkowitz RJ. Mechanisms involved in adrenergic receptor desensitization. Biochem Soc Trans. 1990 Aug; 18(4):541-4. PMID: 2177406.
      Citations:    
    258. Lohse MJ, Benovic JL, Codina J, Caron MG, Lefkowitz RJ. beta-Arrestin: a protein that regulates beta-adrenergic receptor function. Science. 1990 Jun 22; 248(4962):1547-50. PMID: 2163110.
      Citations:    
    259. Lohse MJ, Benovic JL, Caron MG, Lefkowitz RJ. Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors. J Biol Chem. 1990 Feb 25; 265(6):3202-11. PMID: 2154473.
      Citations:    
    260. Benovic JL, Onorato J, Lohse MJ, Dohlman HG, Staniszewski C, Caron MG, Lefkowitz RJ. Synthetic peptides of the hamster beta 2-adrenoceptor as substrates and inhibitors of the beta-adrenoceptor kinase. Br J Clin Pharmacol. 1990; 30 Suppl 1:3S-12S. PMID: 2176526.
      Citations:    
    261. Benovic JL, Onorato JJ, Caron MG, Lefkowitz RJ. Regulation of G protein-coupled receptors by agonist-dependent phosphorylation. Soc Gen Physiol Ser. 1990; 45:87-103. PMID: 1974087.
      Citations:    
    262. Benovic JL, DeBlasi A, Stone WC, Caron MG, Lefkowitz RJ. Beta-adrenergic receptor kinase: primary structure delineates a multigene family. Science. 1989 Oct 13; 246(4927):235-40. PMID: 2552582.
      Citations:    
    263. Kwatra MM, Benovic JL, Caron MG, Lefkowitz RJ, Hosey MM. Phosphorylation of chick heart muscarinic cholinergic receptors by the beta-adrenergic receptor kinase. Biochemistry. 1989 May 30; 28(11):4543-7. PMID: 2765501.
      Citations:    
    264. Lohse MJ, Lefkowitz RJ, Caron MG, Benovic JL. Inhibition of beta-adrenergic receptor kinase prevents rapid homologous desensitization of beta 2-adrenergic receptors. Proc Natl Acad Sci U S A. 1989 May; 86(9):3011-5. PMID: 2541428.
      Citations:    
    265. Benovic JL, Stone WC, Caron MG, Lefkowitz RJ. Inhibition of the beta-adrenergic receptor kinase by polyanions. J Biol Chem. 1989 Apr 25; 264(12):6707-10. PMID: 2468660.
      Citations:    
    266. Krupinski J, Rajaram R, Lakonishok M, Benovic JL, Cerione RA. Insulin-dependent phosphorylation of GTP-binding proteins in phospholipid vesicles. J Biol Chem. 1988 Sep 05; 263(25):12333-41. PMID: 3137226.
      Citations:    
    267. Yang SD, Fong YL, Benovic JL, Sibley DR, Caron MG, Lefkowitz RJ. Dephosphorylation of the beta 2-adrenergic receptor and rhodopsin by latent phosphatase 2. J Biol Chem. 1988 Jun 25; 263(18):8856-8. PMID: 2837466.
      Citations:    
    268. Benovic JL, Staniszewski C, Mayor F, Caron MG, Lefkowitz RJ. beta-Adrenergic receptor kinase. Activity of partial agonists for stimulation of adenylate cyclase correlates with ability to promote receptor phosphorylation. J Biol Chem. 1988 Mar 15; 263(8):3893-7. PMID: 2831211.
      Citations:    
    269. Sibley DR, Benovic JL, Caron MG, Lefkowitz RJ. Phosphorylation of cell surface receptors: a mechanism for regulating signal transduction pathways. Endocr Rev. 1988 Feb; 9(1):38-56. PMID: 2836188.
      Citations:    
    270. Caron MG, Kobilka BK, Frielle T, Bolanowski MA, Benovic JL, Lefkowitz RJ. Cloning of the cDNA and genes for the hamster and human beta 2-adrenergic receptors. J Recept Res. 1988; 8(1-4):7-21. PMID: 2838630.
      Citations:    
    271. Lefkowitz RJ, Kobilka BK, Benovic JL, Bouvier M, Cotecchia S, Hausdorff WP, Dohlman HG, Regan JW, Caron MG. Molecular biology of adrenergic receptors. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 1:507-14. PMID: 2855490.
      Citations:    
    272. Strasser RH, Benovic JL, Lefkowitz RJ, Caron MG. The beta-adrenergic receptor kinase: role in homologous desensitization in S49 lymphoma cells. Adv Exp Med Biol. 1988; 231:503-17. PMID: 2843012.
      Citations:    
    273. Benovic JL, Bouvier M, Caron MG, Lefkowitz RJ. Regulation of adenylyl cyclase-coupled beta-adrenergic receptors. Annu Rev Cell Biol. 1988; 4:405-28. PMID: 2848553.
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    274. Benovic JL, Regan JW, Matsui H, Mayor F, Cotecchia S, Leeb-Lundberg LM, Caron MG, Lefkowitz RJ. Agonist-dependent phosphorylation of the alpha 2-adrenergic receptor by the beta-adrenergic receptor kinase. J Biol Chem. 1987 Dec 25; 262(36):17251-3. PMID: 2826414.
      Citations:    
    275. Benovic JL, K?hn H, Weyand I, Codina J, Caron MG, Lefkowitz RJ. Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein). Proc Natl Acad Sci U S A. 1987 Dec; 84(24):8879-82. PMID: 2827157.
      Citations:    
    276. Dohlman HG, Bouvier M, Benovic JL, Caron MG, Lefkowitz RJ. The multiple membrane spanning topography of the beta 2-adrenergic receptor. Localization of the sites of binding, glycosylation, and regulatory phosphorylation by limited proteolysis. J Biol Chem. 1987 Oct 15; 262(29):14282-8. PMID: 2821000.
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    277. Benovic JL, Mayor F, Staniszewski C, Lefkowitz RJ, Caron MG. Purification and characterization of the beta-adrenergic receptor kinase. J Biol Chem. 1987 Jul 05; 262(19):9026-32. PMID: 3036840.
      Citations:    
    278. Mayor F, Benovic JL, Caron MG, Lefkowitz RJ. Somatostatin induces translocation of the beta-adrenergic receptor kinase and desensitizes somatostatin receptors in S49 lymphoma cells. J Biol Chem. 1987 May 15; 262(14):6468-71. PMID: 2883186.
      Citations:    
    279. Senogles SE, Benovic JL, Amlaiky N, Unson C, Milligan G, Vinitsky R, Spiegel AM, Caron MG. The D2-dopamine receptor of anterior pituitary is functionally associated with a pertussis toxin-sensitive guanine nucleotide binding protein. J Biol Chem. 1987 Apr 05; 262(10):4860-7. PMID: 3104325.
      Citations:    
    280. Sibley DR, Benovic JL, Caron MG, Lefkowitz RJ. Regulation of transmembrane signaling by receptor phosphorylation. Cell. 1987 Mar 27; 48(6):913-22. PMID: 3030559.
      Citations:    
    281. Cerione RA, Gierschik P, Staniszewski C, Benovic JL, Codina J, Somers R, Birnbaumer L, Spiegel AM, Lefkowitz RJ, Caron MG. Functional differences in the beta gamma complexes of transducin and the inhibitory guanine nucleotide regulatory protein. Biochemistry. 1987 Mar 10; 26(5):1485-91. PMID: 3032251.
      Citations:    
    282. Bouvier M, Leeb-Lundberg LM, Benovic JL, Caron MG, Lefkowitz RJ. Regulation of adrenergic receptor function by phosphorylation. II. Effects of agonist occupancy on phosphorylation of alpha 1- and beta 2-adrenergic receptors by protein kinase C and the cyclic AMP-dependent protein kinase. J Biol Chem. 1987 Mar 05; 262(7):3106-13. PMID: 3029101.
      Citations:    
    283. Sibley DR, Benovic JL, Caron MG, Lefkowitz RJ. Molecular mechanisms of beta-adrenergic receptor desensitization. Adv Exp Med Biol. 1987; 221:253-73. PMID: 2829583.
      Citations:    
    284. Benovic JL, Staniszewski C, Cerione RA, Codina J, Lefkowitz RJ, Caron MG. The mammalian beta-adrenergic receptor: structural and functional characterization of the carbohydrate moiety. J Recept Res. 1987; 7(1-4):257-81. PMID: 2887651.
      Citations:    
    285. Sibley DR, Strasser RH, Benovic JL, Daniel K, Lefkowitz RJ. Phosphorylation/dephosphorylation of the beta-adrenergic receptor regulates its functional coupling to adenylate cyclase and subcellular distribution. Proc Natl Acad Sci U S A. 1986 Dec; 83(24):9408-12. PMID: 3025843.
      Citations:    
    286. Strasser RH, Benovic JL, Caron MG, Lefkowitz RJ. Beta-agonist- and prostaglandin E1-induced translocation of the beta-adrenergic receptor kinase: evidence that the kinase may act on multiple adenylate cyclase-coupled receptors. Proc Natl Acad Sci U S A. 1986 Sep; 83(17):6362-6. PMID: 3018728.
      Citations:    
    287. Benovic JL, Mayor F, Somers RL, Caron MG, Lefkowitz RJ. Light-dependent phosphorylation of rhodopsin by beta-adrenergic receptor kinase. Nature. 1986 Jun 26-Jul 2; 321(6073):869-72. PMID: 3014340.
      Citations:    
    288. Benovic JL, Strasser RH, Caron MG, Lefkowitz RJ. Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor. Proc Natl Acad Sci U S A. 1986 May; 83(9):2797-801. PMID: 2871555.
      Citations:    
    289. Dixon RA, Kobilka BK, Strader DJ, Benovic JL, Dohlman HG, Frielle T, Bolanowski MA, Bennett CD, Rands E, Diehl RE, Mumford RA, Slater EE, Sigal IS, Caron MG, Lefkowitz RJ, Strader CD. Cloning of the gene and cDNA for mammalian beta-adrenergic receptor and homology with rhodopsin. Nature. 1986 May 1-7; 321(6065):75-9. PMID: 3010132.
      Citations:    
    290. Cerione RA, Regan JW, Nakata H, Codina J, Benovic JL, Gierschik P, Somers RL, Spiegel AM, Birnbaumer L, Lefkowitz RJ, et al. Functional reconstitution of the alpha 2-adrenergic receptor with guanine nucleotide regulatory proteins in phospholipid vesicles. J Biol Chem. 1986 Mar 15; 261(8):3901-9. PMID: 3005307.
      Citations:    
    291. Benovic JL, Pike LJ, Cerione RA, Staniszewski C, Yoshimasa T, Codina J, Caron MG, Lefkowitz RJ. Phosphorylation of the mammalian beta-adrenergic receptor by cyclic AMP-dependent protein kinase. Regulation of the rate of receptor phosphorylation and dephosphorylation by agonist occupancy and effects on coupling of the receptor to the stimulatory guanine nucleotide regulatory protein. J Biol Chem. 1985 Jun 10; 260(11):7094-101. PMID: 2987243.
      Citations:    
    292. Cerione RA, Staniszewski C, Benovic JL, Lefkowitz RJ, Caron MG, Gierschik P, Somers R, Spiegel AM, Codina J, Birnbaumer L. Specificity of the functional interactions of the beta-adrenergic receptor and rhodopsin with guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles. J Biol Chem. 1985 Feb 10; 260(3):1493-500. PMID: 2981858.
      Citations:    
    293. Caron MG, Cerione RA, Benovic JL, Strulovici B, Staniszewski C, Lefkowitz RJ, Codina-Salada J, Birnbaumer L. Biochemical characterization of the adrenergic receptors: affinity labeling, purification, and reconstitution studies. Adv Cyclic Nucleotide Protein Phosphorylation Res. 1985; 19:1-12. PMID: 2988293.
      Citations:    
    294. Cerione RA, Codina J, Benovic JL, Lefkowitz RJ, Birnbaumer L, Caron MG. The mammalian beta 2-adrenergic receptor: reconstitution of functional interactions between pure receptor and pure stimulatory nucleotide binding protein of the adenylate cyclase system. Biochemistry. 1984 Sep 25; 23(20):4519-25. PMID: 6149763.
      Citations:    
    295. Benovic JL, Shorr RG, Caron MG, Lefkowitz RJ. The mammalian beta 2-adrenergic receptor: purification and characterization. Biochemistry. 1984 Sep 25; 23(20):4510-8. PMID: 6093858.
      Citations:    
    296. Cerione RA, Sibley DR, Codina J, Benovic JL, Winslow J, Neer EJ, Birnbaumer L, Caron MG, Lefkowitz RJ. Reconstitution of a hormone-sensitive adenylate cyclase system. The pure beta-adrenergic receptor and guanine nucleotide regulatory protein confer hormone responsiveness on the resolved catalytic unit. J Biol Chem. 1984 Aug 25; 259(16):9979-82. PMID: 6088509.
      Citations:    
    297. Stiles GL, Benovic JL, Caron MG, Lefkowitz RJ. Mammalian beta-adrenergic receptors. Distinct glycoprotein populations containing high mannose or complex type carbohydrate chains. J Biol Chem. 1984 Jul 10; 259(13):8655-63. PMID: 6330118.
      Citations:    
    298. Cerione RA, Strulovici B, Benovic JL, Lefkowitz RJ, Caron MG. Pure beta-adrenergic receptor: the single polypeptide confers catecholamine responsiveness to adenylate cyclase. Nature. 1983 Dec 8-14; 306(5943):562-6. PMID: 6316161.
      Citations:    
    299. Cerione RA, Strulovici B, Benovic JL, Strader CD, Caron MG, Lefkowitz RJ. Reconstitution of beta-adrenergic receptors in lipid vesicles: affinity chromatography-purified receptors confer catecholamine responsiveness on a heterologous adenylate cyclase system. Proc Natl Acad Sci U S A. 1983 Aug; 80(16):4899-903. PMID: 6308659.
      Citations:    
    300. Benovic J, Tillman T, Cudd A, Fridovich I. Electrostatic facilitation of the reaction catalyzed by the manganese-containing and the iron-containing superoxide dismutases. Arch Biochem Biophys. 1983 Mar; 221(2):329-32. PMID: 6340608.
      Citations:    
    301. Benovic JL, Stiles GL, Lefkowitz RJ, Caron MG. Photoaffinity labelling of mammalian beta-adrenergic receptors: metal-dependent proteolysis explains apparent heterogeneity. Biochem Biophys Res Commun. 1983 Jan 27; 110(2):504-11. PMID: 6301455.
      Citations:    
    302. Li TM, Benovic JL, Burd JF. Serum theophylline determination by fluorescence polarization immunoassay utilizing an umbelliferone derivative as a fluorescent label. Anal Biochem. 1981 Nov 15; 118(1):102-7. PMID: 7337204.
      Citations:    
    303. Li TM, Benovic JL, Buckler RT, Burd JF. Homogeneous substrate-labeled fluorescent immunoassay for theophylline in serum. Clin Chem. 1981 Jan; 27(1):22-6. PMID: 7449119.
      Citations:    
    304. Dunaway-Mariano D, Benovic JL, Cleland WW, Gupta RK, Mildvan AS. Stereospecificity of the metal--adenosine 5'-triphosphate complex in reactions of muscle pyruvate kinase. Biochemistry. 1979 Oct 02; 18(20):4347-54. PMID: 486426.
      Citations:    
    305. Gupta RK, Benovic JL, Rose ZB. Location of the allosteric site for 2,3-bisphosphoglycerate on human oxy- and deoxyhemoglobin as observed by magnetic resonance spectroscopy. J Biol Chem. 1979 Sep 10; 254(17):8250-5. PMID: 224047.
      Citations:    
    306. Gupta RK, Benovic JL. Magnetic resonance and kinetic studies of the spatial arrangement of phosphoenolpyruvate and chromium (III)-adenosine diphosphate at the catalytic site of pyruvate kinase. J Biol Chem. 1978 Dec 25; 253(24):8878-96. PMID: 721820.
      Citations:    
    307. Gupta RK, Benovic JL. Magnetic resonance studies of the interaction of divalent metal cations with 2,3-bisphosphoglycerate. Biochem Biophys Res Commun. 1978 Sep 14; 84(1):130-7. PMID: 728120.
      Citations:    
    308. Gupta RK, Benovic JL, Rose ZB. Magnetic resonance studies of the binding of ATP and cations to human hemoglobin. J Biol Chem. 1978 Sep 10; 253(17):6165-71. PMID: 210170.
      Citations:    
    309. Gupta RK, Benovic JL, Rose ZB. The determination of the free magnesium level in the human red blood cell by 31P NMR. J Biol Chem. 1978 Sep 10; 253(17):6172-6. PMID: 687387.
      Citations:    
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