John Farber

TitleProfessor
InstitutionThomas Jefferson University
DepartmentPathology
Address1020 Locust St.
Philadelphia PA 19107
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    EXTRACURRICULAR ACTIVITIES (1997-present)
    Board of Scientific Counselors, National Institute of Environmental Health Sciences, 1997-Present

    EDITORIAL BOARDS (1997-present):
    Experimental and Molecular Pathology 1983-Present
    Cell Biology and Toxicology 1985-present
    Toxicologic Pathology 1988-1997
    Chemico-Biological Interactions 1990-1998
    Cell Death and Differentiation 1994-Present
    Toxicology In Vitro 1992-Present
    International Hepatology Communications 1992-Present
    Modern Pathology 1995-Present
    Human Pathology 1998-Present


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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Filippone EJ, Farber JL. Histologic Antibody-Mediated Kidney Allograft Rejection in the Absence of Donor Specific HLA Antibodies. Transplantation. 2021 Apr 23. PMID: 33901113.
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    2. Filippone EJ, Farber JL. The Problem of Subclinical Antibody-mediated Rejection in Kidney Transplantation. Transplantation. 2020 Nov 13. PMID: 33196628.
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    3. Filippone EJ, Farber JL. The Monitoring of Donor-Derived Cell-Free DNA (ddcfDNA) in Kidney Transplantation. Transplantation. 2020 Jul 20. PMID: 32732615.
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    4. Fong LY, Taccioli C, Palamarchuk A, Tagliazucchi GM, Jing R, Smalley KJ, Fan S, Altemus J, Fiehn O, Huebner K, Farber JL, Croce CM. Abrogation of esophageal carcinoma development in miR-31 knockout rats. Proc Natl Acad Sci U S A. 2020 Mar 17; 117(11):6075-6085. PMID: 32123074.
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    5. Filippone EJ, Farber JL. The Implications of B-lineage Cells in Kidney Allografts. Transplantation. 2020 Feb 07. PMID: 32039967.
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    6. Forsberg F, Machado P, Stanczak M, Farber J, DiMuzio P, Needleman L. Assessing carotid plaque neovascularity and calcifications in patients prior to endarterectomy. J Vasc Surg. 2019 May 21. PMID: 31126759.
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    7. Fong LY, Jing R, Smalley KJ, Wang ZX, Taccioli C, Fan S, Chen H, Alder H, Huebner K, Farber JL, Fiehn O, Croce CM. Human-like hyperplastic prostate with low ZIP1 induced solely by Zn deficiency in rats. Proc Natl Acad Sci U S A. 2018 11 20; 115(47):E11091-E11100. PMID: 30397150.
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    8. Filippone EJ, McCue PA, Farber JL. Transplant glomerulopathy. Mod Pathol. 2018 Feb; 31(2):235-252. PMID: 29027535.
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    9. Fong LY, Jing R, Smalley KJ, Taccioli C, Fahrmann J, Barupal DK, Alder H, Farber JL, Fiehn O, Croce CM. Integration of metabolomics, transcriptomics, and microRNA expression profiling reveals a miR-143-HK2-glucose network underlying zinc-deficiency-associated esophageal neoplasia. Oncotarget. 2017 Oct 10; 8(47):81910-81925. PMID: 29137232.
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    10. Filippone EJ, Farber JL. The Humoral Theory of Transplantation: Epitope Analysis and the Pathogenicity of HLA Antibodies. J Immunol Res. 2016; 2016:5197396. PMID: 28070526.
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    11. Filippone EJ, Farber JL. Membranous nephropathy in the kidney allograft. Clin Transplant. 2016 Sep 20. PMID: 27646575.
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    12. Oppong YD, Farber JL, Chervoneva I, Martinez Cantarin MP. Correlation of acute tubular injury in reperfusion biopsy with renal transplant outcomes. Clin Transplant. 2016 Jul; 30(7):836-44. PMID: 27146243.
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    13. Fong LY, Farber JL, Croce CM. Zinc intake, microRNA dysregulation, and esophageal cancer. Aging (Albany NY). 2016 Jun; 8(6):1161-2. PMID: 27280381.
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    14. Filippone EJ, Farber JL. Hemophagocytic lymphohistiocytosis: an update for nephrologists. Int Urol Nephrol. 2016 Aug; 48(8):1291-304. PMID: 27098410.
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    15. Fong LY, Taccioli C, Jing R, Smalley KJ, Alder H, Jiang Y, Fadda P, Farber JL, Croce CM. MicroRNA dysregulation and esophageal cancer development depend on the extent of zinc dietary deficiency. Oncotarget. 2016 Mar 8; 7(10):10723-38. PMID: 26918602.
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    16. Mendoza FA, Piera-Velazquez S, Farber JL, Feghali-Bostwick C, Jiménez SA. Endothelial Cells Expressing Endothelial and Mesenchymal Cell Gene Products in Lung Tissue From Patients With Systemic Sclerosis-Associated Interstitial Lung Disease. Arthritis Rheumatol. 2016 Jan; 68(1):210-7. PMID: 26360820.
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    17. O'Hayer K, Farber J, Yeo CJ, Sama AR. HER-2-Positive Ampullary Adenocarcinoma: A Case Report. Case Rep Pancreat Cancer. 2015; 1(1):7-10. PMID: 30631802.
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    18. Taccioli C, Garofalo M, Chen H, Jiang Y, Tagliazucchi GM, Di Leva G, Alder H, Fadda P, Middleton J, Smalley KJ, Selmi T, Naidu S, Farber JL, Croce CM, Fong LY. Repression of Esophageal Neoplasia and Inflammatory Signaling by Anti-miR-31 Delivery In Vivo. J Natl Cancer Inst. 2015 Nov; 107(11). PMID: 26286729.
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    19. Filippone EJ, Farber JL. Humoral Immune Response and Allograft Function in Kidney Transplantation. Am J Kidney Dis. 2015 Aug; 66(2):337-47. PMID: 25987262.
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    20. Filippone EJ, Farber JL. Humoral immunity in renal transplantation: epitopes, Cw and DP, and complement-activating capability - an update. Clin Transplant. 2015 Apr; 29(4):279-87. PMID: 25645090.
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    21. Singh P, Feld RI, Colombe BW, Farber JL, Herman JH, Gulati R, Maley WR, Frank AM. Sensitization, pathologic, and imaging findings comparing symptomatic and quiescent failed renal allografts. Clin Transplant. 2014 Dec; 28(12):1424-32. PMID: 25297845.
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    22. Filippone EJ, Gupta A, Farber JL. Normoglycemic diabetic nephropathy: the role of insulin resistance. Case Rep Nephrol Urol. 2014 May; 4(2):137-43. PMID: 25076962.
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    23. Kim E, Lamb KM, Whisenhunt AK, Ayad M, Farber J, DiMuzio P. Venous cystic adventitial disease of the common femoral vein. J Vasc Surg Venous Lymphat Disord. 2014 Apr; 2(2):194-6. PMID: 26993187.
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    24. Filippone EJ, Farber JL. The specificity of acute and chronic microvascular alterations in renal allografts. Clin Transplant. 2013 Nov; 27(6):790-8. PMID: 24118527.
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    25. Filippone EJ, Chmielewski C, Gulati R, Newman E, Farber JL. De Novo Fibrillary Glomerulonephritis (FGN) in a Renal Transplant with Chronic Hepatitis C. Case Rep Transplant. 2013; 2013:978481. PMID: 23844313.
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    26. Zhou J, Freeman TA, Ahmad F, Shang X, Mangano E, Gao E, Farber J, Wang Y, Ma XL, Woodgett J, Vagnozzi RJ, Lal H, Force T. GSK-3a is a central regulator of age-related pathologies in mice. J Clin Invest. 2013 Apr 1; 123(4):1821-32. PMID: 23549082.
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    27. McClendon AK, Dean JL, Rivadeneira DB, Yu JE, Reed CA, Gao E, Farber JL, Force T, Koch WJ, Knudsen ES. CDK4/6 inhibition antagonizes the cytotoxic response to anthracycline therapy. Cell Cycle. 2012 Jul 15; 11(14):2747-55. PMID: 22751436.
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    28. Alder H, Taccioli C, Chen H, Jiang Y, Smalley KJ, Fadda P, Ozer HG, Huebner K, Farber JL, Croce CM, Fong LY. Dysregulation of miR-31 and miR-21 induced by zinc deficiency promotes esophageal cancer. Carcinogenesis. 2012 Sep; 33(9):1736-44. PMID: 22689922.
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    29. Singh P, Farber JL, Doria C, Francos GC, Gulati R, Ramirez CB, Maley WR, Frank AM. Peritransplant kidney biopsies: comparison of pathologic interpretations and practice patterns of organ procurement organizations. Clin Transplant. 2012 May-Jun; 26(3):E191-9. PMID: 22283182.
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    30. Carson JM, Newman ED, Farber JL, Filippone EJ. Tacrolimus-induced thrombotic microangiopathy: natural history of a severe, acute vasculopathy. Clin Nephrol. 2012 Jan; 77(1):79-84. PMID: 22185974.
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    31. Filippone EJ, Foy A, Galanis T, Pokuah M, Newman E, Lallas CD, Gonsalves CF, Farber JL. Segmental arterial mediolysis: report of 2 cases and review of the literature. Am J Kidney Dis. 2011 Dec; 58(6):981-7. PMID: 21872379.
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    32. Fong LY, Jiang Y, Rawahneh ML, Smalley KJ, Croce CM, Farber JL, Huebner K. Zinc supplementation suppresses 4-nitroquinoline 1-oxide-induced rat oral carcinogenesis. Carcinogenesis. 2011 Apr; 32(4):554-60. PMID: 21245412.
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    33. Wan SG, Taccioli C, Jiang Y, Chen H, Smalley KJ, Huang K, Liu XP, Farber JL, Croce CM, Fong LY. Zinc deficiency activates S100A8 inflammation in the absence of COX-2 and promotes murine oral-esophageal tumor progression. Int J Cancer. 2011 Jul 15; 129(2):331-45. PMID: 20857495.
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    34. Elrod JW, Wong R, Mishra S, Vagnozzi RJ, Sakthievel B, Goonasekera SA, Karch J, Gabel S, Farber J, Force T, Brown JH, Murphy E, Molkentin JD. Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice. J Clin Invest. 2010 Oct; 120(10):3680-7. PMID: 20890047.
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    35. Zhou J, Lal H, Chen X, Shang X, Song J, Li Y, Kerkela R, Doble BW, MacAulay K, DeCaul M, Koch WJ, Farber J, Woodgett J, Gao E, Force T. GSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice. J Clin Invest. 2010 Jul; 120(7):2280-91. PMID: 20516643.
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    36. Hamad EA, Li X, Song J, Zhang XQ, Myers V, Funakoshi H, Zhang J, Wang J, Li J, Swope D, Madonick A, Farber J, Radice GL, Cheung JY, Chan TO, Feldman AM. Effects of cardiac-restricted overexpression of the A(2A) adenosine receptor on adriamycin-induced cardiotoxicity. Am J Physiol Heart Circ Physiol. 2010 Jun; 298(6):H1738-47. PMID: 20363887.
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    37. Pucci B, Indelicato M, Paradisi V, Reali V, Pellegrini L, Aventaggiato M, Karpinich NO, Fini M, Russo MA, Farber JL, Tafani M. ERK-1 MAP kinase prevents TNF-induced apoptosis through bad phosphorylation and inhibition of Bax translocation in HeLa Cells. J Cell Biochem. 2009 Dec 1; 108(5):1166-74. PMID: 19777442.
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    38. Wu KN, Emmons RV, Lisanti MP, Farber JL, Witkiewicz AK. Foxp3-expressing T regulatory cells and mast cells in acute graft-versus-host disease of the skin. Cell Cycle. 2009 Nov 1; 8(21):3593-7. PMID: 19838066.
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    39. Taccioli C, Wan SG, Liu CG, Alder H, Volinia S, Farber JL, Croce CM, Fong LY. Zinc replenishment reverses overexpression of the proinflammatory mediator S100A8 and esophageal preneoplasia in the rat. Gastroenterology. 2009 Mar; 136(3):953-66. PMID: 19111725.
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    40. Pucci B, Bertani F, Karpinich NO, Indelicato M, Russo MA, Farber JL, Tafani M. Detailing the role of Bax translocation, cytochrome c release, and perinuclear clustering of the mitochondria in the killing of HeLa cells by TNF. J Cell Physiol. 2008 Nov; 217(2):442-9. PMID: 18546202.
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    41. Birsner ML, Farber JL, Berghella V. Fatal aortic dissection in a patient with a family history of Marfan syndrome. Obstet Gynecol. 2008 Aug; 112(2 Pt 2):472-5. PMID: 18669769.
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    42. Fong LY, Jiang Y, Riley M, Liu X, Smalley KJ, Guttridge DC, Farber JL. Prevention of upper aerodigestive tract cancer in zinc-deficient rodents: inefficacy of genetic or pharmacological disruption of COX-2. Int J Cancer. 2008 Mar 1; 122(5):978-89. PMID: 17985342.
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    43. Vecchione A, Baldassarre G, Ishii H, Nicoloso MS, Belletti B, Petrocca F, Zanesi N, Fong LY, Battista S, Guarnieri D, Baffa R, Alder H, Farber JL, Donovan PJ, Croce CM. Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development. Cancer Cell. 2007 Mar; 11(3):275-89. PMID: 17349584.
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    44. Tafani M, Karpinich NO, Serroni A, Russo MA, Farber JL. Re-evaluation of the distinction between type I and type II cells: the necessary role of the mitochondria in both the extrinsic and intrinsic signaling pathways upon Fas receptor activation. J Cell Physiol. 2006 Sep; 208(3):556-65. PMID: 16741989.
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    45. Karpinich NO, Tafani M, Schneider T, Russo MA, Farber JL. The course of etoposide-induced apoptosis in Jurkat cells lacking p53 and Bax. J Cell Physiol. 2006 Jul; 208(1):55-63. PMID: 16547931.
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    46. Fong LY, Jiang Y, Farber JL. Zinc deficiency potentiates induction and progression of lingual and esophageal tumors in p53-deficient mice. Carcinogenesis. 2006 Jul; 27(7):1489-96. PMID: 16543248.
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    47. Kayler LK, Farber JL, Colombe B, LaCava D, Friedewald JJ, Ratner LE. Characterization of rejection episodes in patients following positive crossmatch and ABO-incompatible live donor renal transplantation. Transpl Int. 2006 Feb; 19(2):128-39. PMID: 16441362.
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    48. Drusco A, Zanesi N, Roldo C, Trapasso F, Farber JL, Fong LY, Croce CM. Knockout mice reveal a tumor suppressor function for Testin. Proc Natl Acad Sci U S A. 2005 Aug 2; 102(31):10947-51. PMID: 16033868.
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    49. Fong LY, Zhang L, Jiang Y, Farber JL. Dietary zinc modulation of COX-2 expression and lingual and esophageal carcinogenesis in rats. J Natl Cancer Inst. 2005 Jan 5; 97(1):40-50. PMID: 15632379.
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    50. Kayler LK, Colombe B, Farber JL, Lacava D, Dafoe DC, Burke JF, Francos GC, Ratner LE. Successful living donor renal transplantation despite ABO incompatibility and a positive crossmatch. Clin Transplant. 2004 Dec; 18(6):737-42. PMID: 15516254.
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    51. Pechet TT, Carr SR, Collins JE, Cohn HE, Farber JL. Arterial invasion predicts early mortality in stage I non-small cell lung cancer. Ann Thorac Surg. 2004 Nov; 78(5):1748-53. PMID: 15511466.
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    52. Ghohestani RF, Rotunda SL, Hudson B, Gaughan WJ, Farber JL, Webster G, Uitto J. Crescentic glomerulonephritis and subepidermal blisters with autoantibodies to alpha5 and alpha6 chains of type IV collagen. Lab Invest. 2003 May; 83(5):605-11. PMID: 12746470.
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    53. Fong LY, Ishii H, Nguyen VT, Vecchione A, Farber JL, Croce CM, Huebner K. p53 deficiency accelerates induction and progression of esophageal and forestomach tumors in zinc-deficient mice. Cancer Res. 2003 Jan 1; 63(1):186-95. PMID: 12517797.
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    54. Tafani M, Cohn JA, Karpinich NO, Rothman RJ, Russo MA, Farber JL. Regulation of intracellular pH mediates Bax activation in HeLa cells treated with staurosporine or tumor necrosis factor-alpha. J Biol Chem. 2002 Dec 20; 277(51):49569-76. PMID: 12393866.
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    55. Karpinich NO, Tafani M, Rothman RJ, Russo MA, Farber JL. The course of etoposide-induced apoptosis from damage to DNA and p53 activation to mitochondrial release of cytochrome c. J Biol Chem. 2002 May 10; 277(19):16547-52. PMID: 11864976.
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    56. Tafani M, Karpinich NO, Hurster KA, Pastorino JG, Schneider T, Russo MA, Farber JL. Cytochrome c release upon Fas receptor activation depends on translocation of full-length bid and the induction of the mitochondrial permeability transition. J Biol Chem. 2002 Mar 22; 277(12):10073-82. PMID: 11790791.
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