Thomas Jefferson University

John Farber

TitleProfessor
InstitutionThomas Jefferson University
DepartmentPathology - Thomas Jefferson University
Address1020 Locust Street
Philadelphia PA 19107
Phone2155035028
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    EXTRACURRICULAR ACTIVITIES (1997-present)
    Board of Scientific Counselors, National Institute of Environmental Health Sciences, 1997-Present

    EDITORIAL BOARDS (1997-present):
    Experimental and Molecular Pathology 1983-Present
    Cell Biology and Toxicology 1985-present
    Toxicologic Pathology 1988-1997
    Chemico-Biological Interactions 1990-1998
    Cell Death and Differentiation 1994-Present
    Toxicology In Vitro 1992-Present
    International Hepatology Communications 1992-Present
    Modern Pathology 1995-Present
    Human Pathology 1998-Present


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Filippone EJ, Gulati R, Farber JL. The road ahead: emerging therapies for primary IgA nephropathy. Front Nephrol. 2025; 5:1545329. PMID: 39968279.
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    2. Filippone EJ, Gulati R, Farber JL. Contemporary review of IgA nephropathy. Front Immunol. 2024; 15:1436923. PMID: 39188719.
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    3. Hansen CL, Farber J, Binder A, Reist K, Brailovsky Y. Conversion of PYP/HMDP scanning on sequential imaging in a patient with a TTR gene mutation. J Nucl Cardiol. 2024 Jan 11; 101780. PMID: 38216412.
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    4. Fong LY, Huebner K, Jing R, Smalley KJ, Brydges CR, Fiehn O, Farber JL, Croce CM. Zinc treatment reverses and anti-Zn-regulated miRs suppress esophageal carcinomas in?vivo. Proc Natl Acad Sci U S A. 2023 05 16; 120(20):e2220334120. PMID: 37155893.
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    5. Filippone EJ, Farber JL. The Histological Spectrum and Clinical Significance of T Cell-mediated Rejection of Kidney Allografts. Transplantation. 2022 Dec 19. PMID: 36584369.
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    6. Mendoza FA, Bagley J, Gochfeld M, Dalakas MC, Farber JL, Jimenez SA. Progressive multifocal fibrosing neuropathy: description of a novel disease. Acta Neuropathol Commun. 2022 03 16; 10(1):34. PMID: 35296359.
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    7. Filippone EJ, Newman ED, Li L, Gulati R, Farber JL. Thrombotic Microangiopathy, an Unusual Form of Monoclonal Gammopathy of Renal Significance: Report of 3 Cases and Literature Review. Front Immunol. 2021; 12:780107. PMID: 34858436.
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    8. Filippone EJ, Gulati R, Farber JL. Noninvasive Assessment of the Alloimmune Response in Kidney Transplantation. Adv Chronic Kidney Dis. 2021 11; 28(6):548-560. PMID: 35367023.
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    9. Filippone EJ, Farber JL. Histologic Antibody-Mediated Kidney Allograft Rejection in the Absence of Donor Specific HLA Antibodies. Transplantation. 2021 Apr 23. PMID: 33901113.
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    10. Filippone EJ, Farber JL. The Problem of Subclinical Antibody-mediated Rejection in Kidney Transplantation. Transplantation. 2020 Nov 13. PMID: 33196628.
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    11. Filippone EJ, Farber JL. The Monitoring of Donor-Derived Cell-Free DNA (ddcfDNA) in Kidney Transplantation. Transplantation. 2020 Jul 20. PMID: 32732615.
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    12. Fong LY, Taccioli C, Palamarchuk A, Tagliazucchi GM, Jing R, Smalley KJ, Fan S, Altemus J, Fiehn O, Huebner K, Farber JL, Croce CM. Abrogation of esophageal carcinoma development in miR-31 knockout rats. Proc Natl Acad Sci U S A. 2020 Mar 17; 117(11):6075-6085. PMID: 32123074.
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    13. Filippone EJ, Farber JL. The Implications of B-lineage Cells in Kidney Allografts. Transplantation. 2020 Feb 07. PMID: 32039967.
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    14. Forsberg F, Machado P, Stanczak M, Farber J, DiMuzio P, Needleman L. Assessing carotid plaque neovascularity and calcifications in patients prior to endarterectomy. J Vasc Surg. 2019 May 21. PMID: 31126759.
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    15. Fong LY, Jing R, Smalley KJ, Wang ZX, Taccioli C, Fan S, Chen H, Alder H, Huebner K, Farber JL, Fiehn O, Croce CM. Human-like hyperplastic prostate with low ZIP1 induced solely by Zn deficiency in rats. Proc Natl Acad Sci U S A. 2018 11 20; 115(47):E11091-E11100. PMID: 30397150.
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    16. Filippone EJ, McCue PA, Farber JL. Transplant glomerulopathy. Mod Pathol. 2018 Feb; 31(2):235-252. PMID: 29027535.
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    17. Fong LY, Jing R, Smalley KJ, Taccioli C, Fahrmann J, Barupal DK, Alder H, Farber JL, Fiehn O, Croce CM. Integration of metabolomics, transcriptomics, and microRNA expression profiling reveals a miR-143-HK2-glucose network underlying zinc-deficiency-associated esophageal neoplasia. Oncotarget. 2017 Oct 10; 8(47):81910-81925. PMID: 29137232.
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    18. Filippone EJ, Kraft WK, Farber JL. The Nephrotoxicity of Vancomycin. Clin Pharmacol Ther. 2017 Sep; 102(3):459-469. PMID: 28474732.
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    19. Filippone EJ, Farber JL. The Humoral Theory of Transplantation: Epitope Analysis and the Pathogenicity of HLA Antibodies. J Immunol Res. 2016; 2016:5197396. PMID: 28070526.
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    20. Filippone EJ, Singh P, Frank AM, Gupta A, Farber JL. Rapidly Fatal Hemophagocytic Lymphohistiocytosis Developing Within Six Days Following Deceased-Donor Renal Transplantation: Case Report. Transplant Proc. 2016 Nov; 48(9):3123-3127. PMID: 27932162.
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    21. Filippone EJ, Farber JL. Membranous nephropathy in the kidney allograft. Clin Transplant. 2016 Sep 20. PMID: 27646575.
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    22. Oppong YD, Farber JL, Chervoneva I, Martinez Cantarin MP. Correlation of acute tubular injury in reperfusion biopsy with renal transplant outcomes. Clin Transplant. 2016 Jul; 30(7):836-44. PMID: 27146243.
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    23. Fong LY, Farber JL, Croce CM. Zinc intake, microRNA dysregulation, and esophageal cancer. Aging (Albany NY). 2016 Jun; 8(6):1161-2. PMID: 27280381.
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    24. Filippone EJ, Farber JL. Hemophagocytic lymphohistiocytosis: an update for nephrologists. Int Urol Nephrol. 2016 Aug; 48(8):1291-304. PMID: 27098410.
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    25. Fong LY, Taccioli C, Jing R, Smalley KJ, Alder H, Jiang Y, Fadda P, Farber JL, Croce CM. MicroRNA dysregulation and esophageal cancer development depend on the extent of zinc dietary deficiency. Oncotarget. 2016 Mar 8; 7(10):10723-38. PMID: 26918602.
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    26. Mendoza FA, Piera-Velazquez S, Farber JL, Feghali-Bostwick C, Jiménez SA. Endothelial Cells Expressing Endothelial and Mesenchymal Cell Gene Products in Lung Tissue From Patients With Systemic Sclerosis-Associated Interstitial Lung Disease. Arthritis Rheumatol. 2016 Jan; 68(1):210-7. PMID: 26360820.
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    27. O'Hayer K, Farber J, Yeo CJ, Sama AR. HER-2-Positive Ampullary Adenocarcinoma: A Case Report. Case Rep Pancreat Cancer. 2015; 1(1):7-10. PMID: 30631802.
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    28. Malic L, Zhang X, Brassard D, Clime L, Daoud J, Luebbert C, Barrere V, Boutin A, Bidawid S, Farber J, Corneau N, Veres T. Polymer-based microfluidic chip for rapid and efficient immunomagnetic capture and release of Listeria monocytogenes. Lab Chip. 2015 Oct 21; 15(20):3994-4007. PMID: 26346021.
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    29. Taccioli C, Garofalo M, Chen H, Jiang Y, Tagliazucchi GM, Di Leva G, Alder H, Fadda P, Middleton J, Smalley KJ, Selmi T, Naidu S, Farber JL, Croce CM, Fong LY. Repression of Esophageal Neoplasia and Inflammatory Signaling by Anti-miR-31 Delivery In Vivo. J Natl Cancer Inst. 2015 Nov; 107(11). PMID: 26286729.
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    30. Filippone EJ, Farber JL. Humoral Immune Response and Allograft Function in Kidney Transplantation. Am J Kidney Dis. 2015 Aug; 66(2):337-47. PMID: 25987262.
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    31. Filippone EJ, Farber JL. Humoral immunity in renal transplantation: epitopes, Cw and DP, and complement-activating capability - an update. Clin Transplant. 2015 Apr; 29(4):279-87. PMID: 25645090.
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    32. Singh P, Feld RI, Colombe BW, Farber JL, Herman JH, Gulati R, Maley WR, Frank AM. Sensitization, pathologic, and imaging findings comparing symptomatic and quiescent failed renal allografts. Clin Transplant. 2014 Dec; 28(12):1424-32. PMID: 25297845.
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    33. Filippone EJ, Gupta A, Farber JL. Normoglycemic diabetic nephropathy: the role of insulin resistance. Case Rep Nephrol Urol. 2014 May; 4(2):137-43. PMID: 25076962.
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    34. Filippone EJ, Abubacker F, Farber JL. Posttransplantation normoglycemic diabetic nephropathy: the role of the allograft insulin resistance--a case report. Transplant Proc. 2014 Sep; 46(7):2381-5. PMID: 24984885.
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    35. Kim E, Lamb KM, Whisenhunt AK, Ayad M, Farber J, DiMuzio P. Venous cystic adventitial disease of the common femoral vein. J Vasc Surg Venous Lymphat Disord. 2014 Apr; 2(2):194-6. PMID: 26993187.
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    36. Filippone EJ, Farber JL. The specificity of acute and chronic microvascular alterations in renal allografts. Clin Transplant. 2013 Nov; 27(6):790-8. PMID: 24118527.
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    37. Filippone EJ, Chmielewski C, Gulati R, Newman E, Farber JL. De Novo Fibrillary Glomerulonephritis (FGN) in a Renal Transplant with Chronic Hepatitis C. Case Rep Transplant. 2013; 2013:978481. PMID: 23844313.
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    38. Zhou J, Freeman TA, Ahmad F, Shang X, Mangano E, Gao E, Farber J, Wang Y, Ma XL, Woodgett J, Vagnozzi RJ, Lal H, Force T. GSK-3a is a central regulator of age-related pathologies in mice. J Clin Invest. 2013 Apr 1; 123(4):1821-32. PMID: 23549082.
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    39. McClendon AK, Dean JL, Rivadeneira DB, Yu JE, Reed CA, Gao E, Farber JL, Force T, Koch WJ, Knudsen ES. CDK4/6 inhibition antagonizes the cytotoxic response to anthracycline therapy. Cell Cycle. 2012 Jul 15; 11(14):2747-55. PMID: 22751436.
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    40. Alder H, Taccioli C, Chen H, Jiang Y, Smalley KJ, Fadda P, Ozer HG, Huebner K, Farber JL, Croce CM, Fong LY. Dysregulation of miR-31 and miR-21 induced by zinc deficiency promotes esophageal cancer. Carcinogenesis. 2012 Sep; 33(9):1736-44. PMID: 22689922.
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    41. Singh P, Farber JL, Doria C, Francos GC, Gulati R, Ramirez CB, Maley WR, Frank AM. Peritransplant kidney biopsies: comparison of pathologic interpretations and practice patterns of organ procurement organizations. Clin Transplant. 2012 May-Jun; 26(3):E191-9. PMID: 22283182.
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    42. Carson JM, Newman ED, Farber JL, Filippone EJ. Tacrolimus-induced thrombotic microangiopathy: natural history of a severe, acute vasculopathy. Clin Nephrol. 2012 Jan; 77(1):79-84. PMID: 22185974.
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    43. Taccioli C, Chen H, Jiang Y, Liu XP, Huang K, Smalley KJ, Farber JL, Croce CM, Fong LY. Dietary zinc deficiency fuels esophageal cancer development by inducing a distinct inflammatory signature. Oncogene. 2012 Oct 18; 31(42):4550-8. PMID: 22179833.
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    44. Filippone EJ, Carson JM, Beckford RA, Jaffe BC, Newman E, Awsare BK, Doria C, Farber JL. Sirolimus-induced pneumonitis complicated by pentamidine-induced phospholipidosis in a renal transplant recipient: a case report. Transplant Proc. 2011 Sep; 43(7):2792-7. PMID: 21911165.
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    45. Filippone EJ, Foy A, Galanis T, Pokuah M, Newman E, Lallas CD, Gonsalves CF, Farber JL. Segmental arterial mediolysis: report of 2 cases and review of the literature. Am J Kidney Dis. 2011 Dec; 58(6):981-7. PMID: 21872379.
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    46. Fong LY, Jiang Y, Rawahneh ML, Smalley KJ, Croce CM, Farber JL, Huebner K. Zinc supplementation suppresses 4-nitroquinoline 1-oxide-induced rat oral carcinogenesis. Carcinogenesis. 2011 Apr; 32(4):554-60. PMID: 21245412.
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    47. Wan SG, Taccioli C, Jiang Y, Chen H, Smalley KJ, Huang K, Liu XP, Farber JL, Croce CM, Fong LY. Zinc deficiency activates S100A8 inflammation in the absence of COX-2 and promotes murine oral-esophageal tumor progression. Int J Cancer. 2011 Jul 15; 129(2):331-45. PMID: 20857495.
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    48. Elrod JW, Wong R, Mishra S, Vagnozzi RJ, Sakthievel B, Goonasekera SA, Karch J, Gabel S, Farber J, Force T, Brown JH, Murphy E, Molkentin JD. Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice. J Clin Invest. 2010 Oct; 120(10):3680-7. PMID: 20890047.
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    49. Zhou J, Lal H, Chen X, Shang X, Song J, Li Y, Kerkela R, Doble BW, MacAulay K, DeCaul M, Koch WJ, Farber J, Woodgett J, Gao E, Force T. GSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice. J Clin Invest. 2010 Jul; 120(7):2280-91. PMID: 20516643.
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    50. Hamad EA, Li X, Song J, Zhang XQ, Myers V, Funakoshi H, Zhang J, Wang J, Li J, Swope D, Madonick A, Farber J, Radice GL, Cheung JY, Chan TO, Feldman AM. Effects of cardiac-restricted overexpression of the A(2A) adenosine receptor on adriamycin-induced cardiotoxicity. Am J Physiol Heart Circ Physiol. 2010 Jun; 298(6):H1738-47. PMID: 20363887.
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    51. Pucci B, Indelicato M, Paradisi V, Reali V, Pellegrini L, Aventaggiato M, Karpinich NO, Fini M, Russo MA, Farber JL, Tafani M. ERK-1 MAP kinase prevents TNF-induced apoptosis through bad phosphorylation and inhibition of Bax translocation in HeLa Cells. J Cell Biochem. 2009 Dec 1; 108(5):1166-74. PMID: 19777442.
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    52. Wu KN, Emmons RV, Lisanti MP, Farber JL, Witkiewicz AK. Foxp3-expressing T regulatory cells and mast cells in acute graft-versus-host disease of the skin. Cell Cycle. 2009 Nov 1; 8(21):3593-7. PMID: 19838066.
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    53. Taccioli C, Wan SG, Liu CG, Alder H, Volinia S, Farber JL, Croce CM, Fong LY. Zinc replenishment reverses overexpression of the proinflammatory mediator S100A8 and esophageal preneoplasia in the rat. Gastroenterology. 2009 Mar; 136(3):953-66. PMID: 19111725.
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    54. Pucci B, Bertani F, Karpinich NO, Indelicato M, Russo MA, Farber JL, Tafani M. Detailing the role of Bax translocation, cytochrome c release, and perinuclear clustering of the mitochondria in the killing of HeLa cells by TNF. J Cell Physiol. 2008 Nov; 217(2):442-9. PMID: 18546202.
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    55. Birsner ML, Farber JL, Berghella V. Fatal aortic dissection in a patient with a family history of Marfan syndrome. Obstet Gynecol. 2008 Aug; 112(2 Pt 2):472-5. PMID: 18669769.
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    56. Fong LY, Jiang Y, Riley M, Liu X, Smalley KJ, Guttridge DC, Farber JL. Prevention of upper aerodigestive tract cancer in zinc-deficient rodents: inefficacy of genetic or pharmacological disruption of COX-2. Int J Cancer. 2008 Mar 1; 122(5):978-89. PMID: 17985342.
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    57. Vecchione A, Baldassarre G, Ishii H, Nicoloso MS, Belletti B, Petrocca F, Zanesi N, Fong LY, Battista S, Guarnieri D, Baffa R, Alder H, Farber JL, Donovan PJ, Croce CM. Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development. Cancer Cell. 2007 Mar; 11(3):275-89. PMID: 17349584.
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    58. Doria C, di Francesco F, Marino IR, Ramirez CB, Frank A, Iaria M, Galati SA, Farber JL. c-Kit-positive mast cells in portal tracts cannot be used to distinguish acute cellular rejection from recurrent hepatitis C infection in liver allografts. Transplant Proc. 2006 Dec; 38(10):3597-600. PMID: 17175342.
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    59. Doria C, di Francesco F, Ramirez CB, Frank A, Iaria M, Francos G, Marino IR, Farber JL. The presence of B-cell nodules does not necessarily portend a less favorable outcome to therapy in patients with acute cellular rejection of a renal allograft. Transplant Proc. 2006 Dec; 38(10):3441-4. PMID: 17175297.
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    60. Tafani M, Karpinich NO, Serroni A, Russo MA, Farber JL. Re-evaluation of the distinction between type I and type II cells: the necessary role of the mitochondria in both the extrinsic and intrinsic signaling pathways upon Fas receptor activation. J Cell Physiol. 2006 Sep; 208(3):556-65. PMID: 16741989.
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    61. Karpinich NO, Tafani M, Schneider T, Russo MA, Farber JL. The course of etoposide-induced apoptosis in Jurkat cells lacking p53 and Bax. J Cell Physiol. 2006 Jul; 208(1):55-63. PMID: 16547931.
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    62. Marmor DB, Farber JL, Gottlieb JE. Acute respiratory distress syndrome due to pulmonary involvement by neoplastic plasma cells in multiple myeloma. Thorax. 2006 May; 61(5):455-6. PMID: 16648354.
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    63. Fong LY, Jiang Y, Farber JL. Zinc deficiency potentiates induction and progression of lingual and esophageal tumors in p53-deficient mice. Carcinogenesis. 2006 Jul; 27(7):1489-96. PMID: 16543248.
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    64. Kayler LK, Farber JL, Colombe B, LaCava D, Friedewald JJ, Ratner LE. Characterization of rejection episodes in patients following positive crossmatch and ABO-incompatible live donor renal transplantation. Transpl Int. 2006 Feb; 19(2):128-39. PMID: 16441362.
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    65. Drusco A, Zanesi N, Roldo C, Trapasso F, Farber JL, Fong LY, Croce CM. Knockout mice reveal a tumor suppressor function for Testin. Proc Natl Acad Sci U S A. 2005 Aug 2; 102(31):10947-51. PMID: 16033868.
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    66. Fong LY, Zhang L, Jiang Y, Farber JL. Dietary zinc modulation of COX-2 expression and lingual and esophageal carcinogenesis in rats. J Natl Cancer Inst. 2005 Jan 5; 97(1):40-50. PMID: 15632379.
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    67. Kayler LK, Colombe B, Farber JL, Lacava D, Dafoe DC, Burke JF, Francos GC, Ratner LE. Successful living donor renal transplantation despite ABO incompatibility and a positive crossmatch. Clin Transplant. 2004 Dec; 18(6):737-42. PMID: 15516254.
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    68. Pechet TT, Carr SR, Collins JE, Cohn HE, Farber JL. Arterial invasion predicts early mortality in stage I non-small cell lung cancer. Ann Thorac Surg. 2004 Nov; 78(5):1748-53. PMID: 15511466.
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    69. Ghohestani RF, Rotunda SL, Hudson B, Gaughan WJ, Farber JL, Webster G, Uitto J. Crescentic glomerulonephritis and subepidermal blisters with autoantibodies to alpha5 and alpha6 chains of type IV collagen. Lab Invest. 2003 May; 83(5):605-11. PMID: 12746470.
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    70. Fong LY, Ishii H, Nguyen VT, Vecchione A, Farber JL, Croce CM, Huebner K. p53 deficiency accelerates induction and progression of esophageal and forestomach tumors in zinc-deficient mice. Cancer Res. 2003 Jan 1; 63(1):186-95. PMID: 12517797.
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    71. Tafani M, Cohn JA, Karpinich NO, Rothman RJ, Russo MA, Farber JL. Regulation of intracellular pH mediates Bax activation in HeLa cells treated with staurosporine or tumor necrosis factor-alpha. J Biol Chem. 2002 Dec 20; 277(51):49569-76. PMID: 12393866.
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    72. Karpinich NO, Tafani M, Rothman RJ, Russo MA, Farber JL. The course of etoposide-induced apoptosis from damage to DNA and p53 activation to mitochondrial release of cytochrome c. J Biol Chem. 2002 May 10; 277(19):16547-52. PMID: 11864976.
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    73. Tafani M, Karpinich NO, Hurster KA, Pastorino JG, Schneider T, Russo MA, Farber JL. Cytochrome c release upon Fas receptor activation depends on translocation of full-length bid and the induction of the mitochondrial permeability transition. J Biol Chem. 2002 Mar 22; 277(12):10073-82. PMID: 11790791.
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    74. Fong LY, Nguyen VT, Farber JL. Esophageal cancer prevention in zinc-deficient rats: rapid induction of apoptosis by replenishing zinc. J Natl Cancer Inst. 2001 Oct 17; 93(20):1525-33. PMID: 11604475.
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    75. Nordstrom CR, Kane GC, Wechsler RJ, Salazar AM, Cohn HE, Farber JL. Bronchial atresia with relapsing pulmonary infection in a middle-aged man. Respir Care. 2001 Jun; 46(6):601-3. PMID: 11353549.
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    76. Tafani M, Minchenko DA, Serroni A, Farber JL. Induction of the mitochondrial permeability transition mediates the killing of HeLa cells by staurosporine. Cancer Res. 2001 Mar 15; 61(6):2459-66. PMID: 11289115.
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    77. Sato N, Mizumoto K, Nakamura M, Ueno H, Minamishima YA, Farber JL, Tanaka M. A possible role for centrosome overduplication in radiation-induced cell death. Oncogene. 2000 Nov 02; 19(46):5281-90. PMID: 11077445.
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    78. Fong LY, Nguyen VT, Farber JL, Huebner K, Magee PN. Early deregulation of the the p16ink4a-cyclin D1/cyclin-dependent kinase 4-retinoblastoma pathway in cell proliferation-driven esophageal tumorigenesis in zinc-deficient rats. Cancer Res. 2000 Aug 15; 60(16):4589-95. PMID: 10969811.
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    79. Tafani M, Schneider TG, Pastorino JG, Farber JL. Cytochrome c-dependent activation of caspase-3 by tumor necrosis factor requires induction of the mitochondrial permeability transition. Am J Pathol. 2000 Jun; 156(6):2111-21. PMID: 10854232.
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    80. Pastorino JG, Tafani M, Rothman RJ, Marcinkeviciute A, Hoek JB, Farber JL, Marcineviciute A. Functional consequences of the sustained or transient activation by Bax of the mitochondrial permeability transition pore. J Biol Chem. 1999 Oct 29; 274(44):31734-9. PMID: 10531385.
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    81. Pastorino JG, Tafani M, Farber JL. Tumor necrosis factor induces phosphorylation and translocation of BAD through a phosphatidylinositide-3-OH kinase-dependent pathway. J Biol Chem. 1999 Jul 02; 274(27):19411-6. PMID: 10383455.
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    82. Fong LY, Farber JL, Magee PN. Zinc replenishment reduces esophageal cell proliferation and N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumor incidence in zinc-deficient rats. Carcinogenesis. 1998 Sep; 19(9):1591-6. PMID: 9771929.
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    83. Albertine KH, Steiner RM, Radack DM, Golding DM, Peterson D, Cohn HE, Farber JL. Analysis of cell type and radiographic presentation as predictors of the clinical course of patients with bronchioalveolar cell carcinoma. Chest. 1998 Apr; 113(4):997-1006. PMID: 9554638.
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    84. Pastorino JG, Chen ST, Tafani M, Snyder JW, Farber JL. The overexpression of Bax produces cell death upon induction of the mitochondrial permeability transition. J Biol Chem. 1998 Mar 27; 273(13):7770-5. PMID: 9516487.
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    85. Simbula G, Glascott PA, Akita S, Hoek JB, Farber JL. Two mechanisms by which ATP depletion potentiates induction of the mitochondrial permeability transition. Am J Physiol. 1997 Aug; 273(2 Pt 1):C479-88. PMID: 9277345.
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    86. Spitsin SV, Farber JL, Bertovich M, Moehren G, Koprowski H, Michaels FH. Human- and mouse-inducible nitric oxide synthase promoters require activation of phosphatidylcholine-specific phospholipase C and NF-kappa B. Mol Med. 1997 May; 3(5):315-26. PMID: 9205947.
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    87. Hooper DC, Bagasra O, Marini JC, Zborek A, Ohnishi ST, Kean R, Champion JM, Sarker AB, Bobroski L, Farber JL, Akaike T, Maeda H, Koprowski H. Prevention of experimental allergic encephalomyelitis by targeting nitric oxide and peroxynitrite: implications for the treatment of multiple sclerosis. Proc Natl Acad Sci U S A. 1997 Mar 18; 94(6):2528-33. PMID: 9122229.
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    88. Pastorino JG, Simbula G, Yamamoto K, Glascott PA, Rothman RJ, Farber JL. The cytotoxicity of tumor necrosis factor depends on induction of the mitochondrial permeability transition. J Biol Chem. 1996 Nov 22; 271(47):29792-8. PMID: 8939917.
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    89. S?nchez-G?ngora E, Pastorino JG, Alvarez L, Pajares MA, Garc?a C, Vi?a JR, Mato JM, Farber JL. Increased sensitivity to oxidative injury in chinese hamster ovary cells stably transfected with rat liver S-adenosylmethionine synthetase cDNA. Biochem J. 1996 Nov 01; 319 ( Pt 3):767-73. PMID: 8920979.
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    90. Glascott PA, Gilfor E, Serroni A, Farber JL. Independent antioxidant action of vitamins E and C in cultured rat hepatocytes intoxicated with allyl alcohol. Biochem Pharmacol. 1996 Oct 25; 52(8):1245-52. PMID: 8937432.
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    91. Glascott PA, Tsyganskaya M, Gilfor E, Zern MA, Farber JL. The antioxidant function of the physiological content of vitamin C. Mol Pharmacol. 1996 Oct; 50(4):994-9. PMID: 8863846.
      Citations:    
    92. Fong LY, Li JX, Farber JL, Magee PN. Cell proliferation and esophageal carcinogenesis in the zinc-deficient rat. Carcinogenesis. 1996 Sep; 17(9):1841-8. PMID: 8824504.
      Citations:    
    93. Sostman HD, Layish DT, Tapson VF, Spritzer CE, DeLong DM, Trotter P, MacFall JR, Patz EF, Goodman PC, Woodard PK, Foo TK, Farber JL. Prospective comparison of helical CT and MR imaging in clinically suspected acute pulmonary embolism. J Magn Reson Imaging. 1996 Mar-Apr; 6(2):275-81. PMID: 9132089.
      Citations:    
    94. Glascott PA, Gilfor E, Farber JL. Relationship of the metabolism of vitamins C and E in cultured hepatocytes treated with tert-butyl hydroperoxide. Mol Pharmacol. 1995 Jul; 48(1):80-8. PMID: 7623778.
      Citations:    
    95. Mizumoto K, Farber JL. Growth inhibition and cell killing by N-methyl-N-nitrosourea: metabolic alterations that accompany poly(ADP-ribosyl)ation. Arch Biochem Biophys. 1995 Jun 01; 319(2):512-8. PMID: 7786036.
      Citations:    
    96. Hoek JB, Farber JL, Thomas AP, Wang X. Calcium ion-dependent signalling and mitochondrial dysfunction: mitochondrial calcium uptake during hormonal stimulation in intact liver cells and its implication for the mitochondrial permeability transition. Biochim Biophys Acta. 1995 May 24; 1271(1):93-102. PMID: 7599232.
      Citations:    
    97. Pastorino JG, Wilhelm TJ, Glascott PA, Kocsis JJ, Farber JL. Dexamethasone induces resistance to the lethal consequences of electron transport inhibition in cultured hepatocytes. Arch Biochem Biophys. 1995 Apr 01; 318(1):175-81. PMID: 7726559.
      Citations:    
    98. Pastorino JG, Snyder JW, Hoek JB, Farber JL. Ca2+ depletion prevents anoxic death of hepatocytes by inhibiting mitochondrial permeability transition. Am J Physiol. 1995 Mar; 268(3 Pt 1):C676-85. PMID: 7900774.
      Citations:    
    99. Snyder JW, Serroni A, Savory J, Farber JL. The absence of extracellular calcium potentiates the killing of cultured hepatocytes by aluminum maltolate. Arch Biochem Biophys. 1995 Jan 10; 316(1):434-42. PMID: 7840648.
      Citations:    
    100. Pastorino JG, Simbula G, Gilfor E, Hoek JB, Farber JL. Protoporphyrin IX, an endogenous ligand of the peripheral benzodiazepine receptor, potentiates induction of the mitochondrial permeability transition and the killing of cultured hepatocytes by rotenone. J Biol Chem. 1994 Dec 09; 269(49):31041-6. PMID: 7983042.
      Citations:    
    101. Farber JL. Mechanisms of cell injury by activated oxygen species. Environ Health Perspect. 1994 Dec; 102 Suppl 10:17-24. PMID: 7705293.
      Citations:    
    102. Mizumoto K, Rothman RJ, Farber JL. Programmed cell death (apoptosis) of mouse fibroblasts is induced by the topoisomerase II inhibitor etoposide. Mol Pharmacol. 1994 Nov; 46(5):890-5. PMID: 7969076.
      Citations:    
    103. Russo MA, Morgante E, Mariani MF, Yeh HI, Farber JL, van Rossum GD. Effects of ouabain and chloride-free medium on isoosmotic volume control and ultrastructure of hepatocytes in primary culture. Eur J Cell Biol. 1994 Aug; 64(2):229-42. PMID: 7813511.
      Citations:    
    104. Mizumoto K, Glascott PA, Farber JL. Roles for oxidative stress and poly(ADP-ribosyl)ation in the killing of cultured hepatocytes by methyl methanesulfonate. Biochem Pharmacol. 1993 Nov 17; 46(10):1811-8. PMID: 8250968.
      Citations:    
    105. Tsukidate K, Yamamoto K, Snyder JW, Farber JL. Microtubule antagonists activate programmed cell death (apoptosis) in cultured rat hepatocytes. Am J Pathol. 1993 Sep; 143(3):918-25. PMID: 8362985.
      Citations:    
    106. Snyder JW, Alexander GM, Ferraro TN, Grothusen JR, Farber JL. N-methyl-4-phenylpyridinium (MPP+) potentiates the killing of cultured hepatocytes by catecholamines. Chem Biol Interact. 1993 Sep; 88(2-3):209-23. PMID: 8403080.
      Citations:    
    107. Yamamoto K, Tsukidate K, Farber JL. Differing effects of the inhibition of poly(ADP-ribose) polymerase on the course of oxidative cell injury in hepatocytes and fibroblasts. Biochem Pharmacol. 1993 Aug 03; 46(3):483-91. PMID: 8347172.
      Citations:    
    108. Pastorino JG, Snyder JW, Serroni A, Hoek JB, Farber JL. Cyclosporin and carnitine prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition. J Biol Chem. 1993 Jul 05; 268(19):13791-8. PMID: 8314748.
      Citations:    
    109. Snyder JW, Pastorino JG, Thomas AP, Hoek JB, Farber JL. ATP synthase activity is required for fructose to protect cultured hepatocytes from the toxicity of cyanide. Am J Physiol. 1993 Mar; 264(3 Pt 1):C709-14. PMID: 8460673.
      Citations:    
    110. Rothman RJ, Serroni A, Farber JL. Cellular pool of transient ferric iron, chelatable by deferoxamine and distinct from ferritin, that is involved in oxidative cell injury. Mol Pharmacol. 1992 Oct; 42(4):703-10. PMID: 1435746.
      Citations:    
    111. Sakaida I, Thomas AP, Farber JL. Phospholipid metabolism and intracellular Ca2+ homeostasis in cultured rat hepatocytes intoxicated with cyanide. Am J Physiol. 1992 Sep; 263(3 Pt 1):C684-90. PMID: 1415517.
      Citations:    
    112. Snyder JW, Pastorino JG, Attie AM, Farber JL. Protection by cyclosporin A of cultured hepatocytes from the toxic consequences of the loss of mitochondrial energization produced by 1-methyl-4-phenylpyridinium. Biochem Pharmacol. 1992 Aug 18; 44(4):833-5. PMID: 1510732.
      Citations:    
    113. Glascott PA, Gilfor E, Farber JL. Effects of vitamin E on the killing of cultured hepatocytes by tert-butyl hydroperoxide. Mol Pharmacol. 1992 Jun; 41(6):1155-62. PMID: 1614414.
      Citations:    
    114. Yamamoto K, Farber JL. Metabolism of pyridine nucleotides in cultured rat hepatocytes intoxicated with tert-butyl hydroperoxide. Biochem Pharmacol. 1992 Mar 03; 43(5):1119-26. PMID: 1554384.
      Citations:    
    115. Harman AW, Kyle ME, Serroni A, Farber JL. The killing of cultured hepatocytes by N-acetyl-p-benzoquinone imine (NAPQI) as a model of the cytotoxicity of acetaminophen. Biochem Pharmacol. 1991 Apr 15; 41(8):1111-7. PMID: 2009090.
      Citations:    
    116. Sakaida I, Thomas AP, Farber JL. Increases in cytosolic calcium ion concentration can be dissociated from the killing of cultured hepatocytes by tert-butyl hydroperoxide. J Biol Chem. 1991 Jan 15; 266(2):717-22. PMID: 1985959.
      Citations:    
    117. Farber JL. The role of calcium in lethal cell injury. Chem Res Toxicol. 1990 Nov-Dec; 3(6):503-8. PMID: 2103321.
      Citations:    
    118. Kyle ME, Sakaida I, Serroni A, Farber JL. Metabolism of acetaminophen by cultured rat hepatocytes. Depletion of protein thiol groups without any loss of viability. Biochem Pharmacol. 1990 Sep 15; 40(6):1211-8. PMID: 2403376.
      Citations:    
    119. Coleman JB, Casini AF, Serroni A, Farber JL. Evidence for the participation of activated oxygen species and the resulting peroxidation of lipids in the killing of cultured hepatocytes by aryl halides. Toxicol Appl Pharmacol. 1990 Sep 15; 105(3):393-402. PMID: 2237914.
      Citations:    
    120. Farber JL, Kyle ME, Coleman JB. Mechanisms of cell injury by activated oxygen species. Lab Invest. 1990 Jun; 62(6):670-9. PMID: 2162996.
      Citations:    
    121. Farber JL. The role of calcium ions in toxic cell injury. Environ Health Perspect. 1990 Mar; 84:107-11. PMID: 2190804.
      Citations:    
    122. Sakaida I, Kyle ME, Farber JL. Autophagic degradation of protein generates a pool of ferric iron required for the killing of cultured hepatocytes by an oxidative stress. Mol Pharmacol. 1990 Mar; 37(3):435-42. PMID: 2314391.
      Citations:    
    123. Rubin E, Farber JL. Environmental diseases of the digestive system. Med Clin North Am. 1990 Mar; 74(2):413-24. PMID: 2181212.
      Citations:    
    124. Kyle ME, Nakae D, Sakaida S, Serroni A, Farber JL. Protein thiol depletion and the killing of cultured hepatocytes by hydrogen peroxide. Biochem Pharmacol. 1989 Nov 01; 38(21):3797-805. PMID: 2597173.
      Citations:    
    125. Farber JL, Holowecky OO, Serroni A, van Rossum GD. Effects of ouabain on potassium transport and cell volume regulation in rat and rabbit liver. J Physiol. 1989 Oct; 417:389-402. PMID: 2621601.
      Citations:    
    126. Masaki N, Sakaida I, Farber JL. Protease inhibitors do not prevent the killing of cultured hepatocytes by cystamine. Biochem Biophys Res Commun. 1989 Aug 30; 163(1):412-7. PMID: 2775274.
      Citations:    
    127. Coleman JB, Gilfor D, Farber JL. Dissociation of the accumulation of single-strand breaks in DNA from the killing of cultured hepatocytes by an oxidative stress. Mol Pharmacol. 1989 Jul; 36(1):193-200. PMID: 2747626.
      Citations:    
    128. Masaki N, Thomas AP, Hoek JB, Farber JL. Intracellular acidosis protects cultured hepatocytes from the toxic consequences of a loss of mitochondrial energization. Arch Biochem Biophys. 1989 Jul; 272(1):152-61. PMID: 2735760.
      Citations:    
    129. Masaki N, Kyle ME, Serroni A, Farber JL. Mitochondrial damage as a mechanism of cell injury in the killing of cultured hepatocytes by tert-butyl hydroperoxide. Arch Biochem Biophys. 1989 May 01; 270(2):672-80. PMID: 2705785.
      Citations:    
    130. Masaki N, Kyle ME, Farber JL. tert-butyl hydroperoxide kills cultured hepatocytes by peroxidizing membrane lipids. Arch Biochem Biophys. 1989 Mar; 269(2):390-9. PMID: 2919876.
      Citations:    
    131. Kyle ME, Serroni A, Farber JL. The inhibition of lipid peroxidation by disulfiram prevents the killing of cultured hepatocytes by allyl alcohol, tert-butyl hydroperoxide, hydrogen peroxide and diethyl maleate. Chem Biol Interact. 1989; 72(3):269-75. PMID: 2605670.
      Citations:    
    132. Farber JL, Leonard TB, Kyle ME, Nakae D, Serroni A, Rogers SA. Peroxidation-dependent and peroxidation-independent mechanisms by which acetaminophen kills cultured rat hepatocytes. Arch Biochem Biophys. 1988 Dec; 267(2):640-50. PMID: 3214174.
      Citations:    
    133. Nakae D, Oakes JW, Farber JL. Potentiation in the intact rat of the hepatotoxicity of acetaminophen by 1,3-bis(2-chloroethyl)-1-nitrosourea. Arch Biochem Biophys. 1988 Dec; 267(2):651-9. PMID: 3214175.
      Citations:    
    134. Kyle ME, Nakae D, Serroni A, Farber JL. 1,3-(2-Chloroethyl)-1-nitrosourea potentiates the toxicity of acetaminophen both in the phenobarbital-induced rat and in hepatocytes cultured from such animals. Mol Pharmacol. 1988 Oct; 34(4):584-9. PMID: 3173337.
      Citations:    
    135. Miccadei S, Nakae D, Kyle ME, Gilfor D, Farber JL. Oxidative cell injury in the killing of cultured hepatocytes by allyl alcohol. Arch Biochem Biophys. 1988 Sep; 265(2):302-10. PMID: 3421708.
      Citations:    
    136. Miccadei S, Kyle ME, Gilfor D, Farber JL. Toxic consequence of the abrupt depletion of glutathione in cultured rat hepatocytes. Arch Biochem Biophys. 1988 Sep; 265(2):311-20. PMID: 3421709.
      Citations:    
    137. Kyle ME, Nakae D, Sakaida I, Miccadei S, Farber JL. Endocytosis of superoxide dismutase is required in order for the enzyme to protect hepatocytes from the cytotoxicity of hydrogen peroxide. J Biol Chem. 1988 Mar 15; 263(8):3784-9. PMID: 3346222.
      Citations:    
    138. Kyle ME, Miccadei S, Nakae D, Farber JL. Superoxide dismutase and catalase protect cultured hepatocytes from the cytotoxicity of acetaminophen. Biochem Biophys Res Commun. 1987 Dec 31; 149(3):889-96. PMID: 3122747.
      Citations:    
    139. Russo MA, Kane AB, Farber JL. Ultrastruct pathology of phalloidin-intoxicated hepatocytes in the presence and absence of extracellular calcium. Am J Pathol. 1982 Nov; 109(2):133-44. PMID: 6890315.
      Citations:    
    140. Farber JL. Biology of disease: membrane injury and calcium homeostasis in the pathogenesis of coagulative necrosis. Lab Invest. 1982 Aug; 47(2):114-23. PMID: 7109537.
      Citations:    
    141. Farber JL. The role of calcium in cell death. Life Sci. 1981 Sep 28; 29(13):1289-95. PMID: 7026953.
      Citations:    
    142. Kane AB, Stanton RP, Raymond EG, Dobson ME, Knafelc ME, Farber JL. Dissociation of intracellular lysosomal rupture from the cell death caused by silica. J Cell Biol. 1980 Dec; 87(3 Pt 1):643-51. PMID: 6161936.
      Citations:    
    143. Herzog J, Farber JL. Inhibition of rat liver RNA polymerases by action of the methylating agents dimethylnitrosamine in vivo and methyl methanesulfonate in vitro. Cancer Res. 1976 May; 36(5):1761-70. PMID: 178432.
      Citations:    
    144. Herzog J, Serroni A, Briesmeister BA, Farber JL. N-hydroxy-2-acetylaminofluorene inhibition of rat live RNA polymerases. Cancer Res. 1975 Aug; 35(8):2138-44. PMID: 1149028.
      Citations:    
    145. Farber JL, Shinozuka H, Serroni A, Farmar R. Reversal of the ethionine-induced inhibition of rat liver ribonucleic acid polymerases in vivo by adenine. Lab Invest. 1974 Nov; 31(5):465-72. PMID: 4431228.
      Citations:    
    146. Konishi Y, Shinozuka H, Farber JL. The inhibition of rat liver nuclear ribonucleic acid synthesis by galactosamine and its reversal by uridine. Lab Invest. 1974 Jun; 30(6):751-6. PMID: 4835601.
      Citations:    
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