John Pascal

TitleVolunteer Faculty
InstitutionThomas Jefferson University
DepartmentFaculty Records
Address1025 Walnut St.
Philadelphia PA 19107
Phone215-503-4596
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    F32GM070151     (PASCAL, JOHN)Apr 1, 2004 - Mar 31, 2005
    NIH
    Protein-Protein Interactions in DNA Repair Pathways
    Role: Principal Investigator

    R01GM087282     (PASCAL, JOHN M)Dec 1, 2010 - Nov 30, 2017
    NIH
    Structural Biochemistry of PARP-1
    Role: Principal Investigator

    R01CA259037     (BLACK, BEN E.)Mar 1, 2022 - Feb 28, 2027
    NIH
    Tuning PARP-1 retention and release on DNA breaks
    Role: Co-Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Valerie NCK, Sanjiv K, Mortusewicz O, Zhang SM, Alam S, Pires MJ, Stigsdotter H, Rasti A, Langelier MF, Rehling D, Throup A, Purewal-Sidhu O, Desroses M, Onireti J, Wakchaure P, Alml?f I, Bostr?m J, Bevc L, Benzi G, Stenmark P, Pascal JM, Helleday T, Page BDG, Altun M. Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM. Nat Commun. 2024 Dec 06; 15(1):10347. PMID: 39643609.
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    2. Langelier MF, Mirhasan M, Gilbert K, Sverzhinksy A, Furtos A, Pascal JM. PARP enzyme de novo synthesis of protein-free poly(ADP-ribose). Mol Cell. 2024 Nov 07. PMID: 39536748.
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    3. Smith-Pillet ES, Billur R, Langelier MF, Talele TT, Pascal JM, Black BE. A PARP2-specific active site a-helix melts to permit DNA damage-induced enzymatic activation. bioRxiv. 2024 May 20. PMID: 38826291.
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    4. Velagapudi UK, Rouleau-Turcotte ?, Billur R, Shao X, Patil M, Black BE, Pascal J, Talele TT. Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks. Biochem J. 2024 Feb 19. PMID: 38372302.
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    5. Frigon L, Pascal JM. Structural and biochemical analysis of the PARP1-homology region of PARP4/vault PARP. Nucleic Acids Res. 2023 Nov 16. PMID: 37971310.
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    6. Rouleau-Turcotte ?, Pascal JM. ADP-ribose contributions to genome stability, and PARP enzyme trapping on sites of DNA damage; paradigm shifts for a coming-of-age modification. J Biol Chem. 2023 Oct 26; 105397. PMID: 37898399.
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    7. Pascal JM. PARP-nucleic acid interactions: Allosteric signaling, PARP inhibitor types, DNA bridges, and viral RNA surveillance. Curr Opin Struct Biol. 2023 Jun 21; 81:102643. PMID: 37352603.
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    8. Langelier MF, Lin X, Zha S, Pascal JM. Clinical PARP inhibitors allosterically induce PARP2 retention on DNA. Sci Adv. 2023 Mar 24; 9(12):eadf7175. PMID: 36961901.
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    9. Laspata N, Kaur P, Mersaoui SY, Muoio D, Liu ZS, Bannister MH, Nguyen HD, Curry C, Pascal JM, Poirier GG, Wang H, Masson JY, Fouquerel E. PARP1 associates with R-loops to promote their resolution and genome stability. Nucleic Acids Res. 2023 Feb 16. PMID: 36794853.
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    10. Arnold MR, Langelier MF, Gartrell J, Kirby IT, Sanderson DJ, Bejan DS, ?ileikyte J, Sundalam SK, Nagarajan S, Marimuthu P, Duell AK, Shelat AA, Pascal JM, Cohen MS. Allosteric regulation of DNA binding and target residence time drive the cytotoxicity of phthalazinone-based PARP-1 inhibitors. Cell Chem Biol. 2022 12 15; 29(12):1694-1708.e10. PMID: 36493759.
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    11. Kuttiyatveetil JRA, Soufari H, Dasovich M, Uribe IR, Mirhasan M, Cheng SJ, Leung AKL, Pascal JM. Crystal structures and functional analysis of the ZnF5-WWE1-WWE2 region of PARP13/ZAP define a distinctive mode of engaging poly(ADP-ribose). Cell Rep. 2022 10 25; 41(4):111529. PMID: 36288691.
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    12. Gopinathan Nair A, Rabas N, Lejon S, Homiski C, Osborne MJ, Cyr N, Sverzhinsky A, Melendy T, Pascal JM, Laue ED, Borden KLB, Omichinski JG, Verreault A. Unorthodox PCNA Binding by Chromatin Assembly Factor 1. Int J Mol Sci. 2022 Sep 21; 23(19). PMID: 36232396.
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    13. Xue H, Bhardwaj A, Yin Y, Fijen C, Ephstein A, Zhang L, Ding X, Pascal JM, VanArsdale TL, Rothenberg E. A two-step mechanism governing PARP1-DNA retention by PARP inhibitors. Sci Adv. 2022 Sep 09; 8(36):eabq0414. PMID: 36070389.
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    14. Rouleau-Turcotte É, Krastev DB, Pettitt SJ, Lord CJ, Pascal JM. Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery. Mol Cell. 2022 Jun 28. PMID: 35793673.
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    15. Kotova EY, Hsieh FK, Chang HW, Maluchenko NV, Langelier MF, Pascal JM, Luse DS, Feofanov AV, Studitsky VM. Human PARP1 Facilitates Transcription through a Nucleosome and Histone Displacement by Pol II In Vitro. Int J Mol Sci. 2022 Jun 26; 23(13). PMID: 35806109.
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    16. Rashid I, Tsai MS, Sverzhinsky A, Hlaing AS, Shih B, Thwin AC, Lin JG, Maw SS, Pascal JM, Tomkinson AE. Purification and Characterization of Human DNA Ligase IIIa Complexes After Expression in Insect Cells. Methods Mol Biol. 2022; 2444:243-269. PMID: 35290642.
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    17. Sverzhinsky A, Tomkinson AE, Pascal JM. Cryo-EM structures and biochemical insights into heterotrimeric PCNA regulation of DNA ligase. Structure. 2022 Mar 03; 30(3):371-385.e5. PMID: 34838188.
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    18. Langelier MF, Billur R, Sverzhinsky A, Black BE, Pascal JM. HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications. Nat Commun. 2021 11 18; 12(1):6675. PMID: 34795260.
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    19. Maluchenko NV, Nilov DK, Pushkarev SV, Kotova EY, Gerasimova NS, Kirpichnikov MP, Langelier MF, Pascal JM, Akhtar MS, Feofanov AV, Studitsky VM. Mechanisms of Nucleosome Reorganization by PARP1. Int J Mol Sci. 2021 Nov 09; 22(22). PMID: 34830005.
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    20. Sun Y, Chen J, Huang SN, Su YP, Wang W, Agama K, Saha S, Jenkins LM, Pascal JM, Pommier Y. PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation. Nat Commun. 2021 08 18; 12(1):5010. PMID: 34408146.
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    21. Lüscher B, Ahel I, Altmeyer M, Ashworth A, Bai P, Chang P, Cohen M, Corda D, Dantzer F, Daugherty MD, Dawson TM, Dawson VL, Deindl S, Fehr AR, Feijs KLH, Filippov DV, Gagné JP, Grimaldi G, Guettler S, Hoch NC, Hottiger MO, Korn P, Kraus WL, Ladurner A, Lehtiö L, Leung AKL, Lord CJ, Mangerich A, Matic I, Matthews J, Moldovan GL, Moss J, Natoli G, Nielsen ML, Niepel M, Nolte F, Pascal J, Paschal BM, Pawlowski K, Poirier GG, Smith S, Timinszky G, Wang ZQ, Yélamos J, Yu X, Zaja R, Ziegler M. ADP-ribosyltransferases, an update on function and nomenclature. FEBS J. 2021 Jul 29. PMID: 34323016.
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    22. Rashid I, Hammel M, Sverzhinsky A, Tsai MS, Pascal JM, Tainer JA, Tomkinson AE. Direct interaction of DNA repair protein tyrosyl DNA phosphodiesterase 1 and the DNA ligase III catalytic domain is regulated by phosphorylation of its flexible N-terminus. J Biol Chem. 2021 Aug; 297(2):100921. PMID: 34181949.
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    23. Ogden TEH, Yang JC, Schimpl M, Easton LE, Underwood E, Rawlins PB, McCauley MM, Langelier MF, Pascal JM, Embrey KJ, Neuhaus D. Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition. Nucleic Acids Res. 2021 02 26; 49(4):2266-2288. PMID: 33511412.
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    24. Hammel M, Rashid I, Sverzhinsky A, Pourfarjam Y, Tsai MS, Ellenberger T, Pascal JM, Kim IK, Tainer JA, Tomkinson AE. An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase IIIa within a flexible DNA repair complex. Nucleic Acids Res. 2021 01 11; 49(1):306-321. PMID: 33330937.
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    25. Genois MM, Gagné JP, Yasuhara T, Jackson J, Saxena S, Langelier MF, Ahel I, Bedford MT, Pascal JM, Vindigni A, Poirier GG, Zou L. CARM1 regulates replication fork speed and stress response by stimulating PARP1. Mol Cell. 2020 Dec 30. PMID: 33412112.
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    26. Serrano D, Cordero G, Kawamura R, Sverzhinsky A, Sarker M, Roy S, Malo C, Pascal JM, Marko JF, D'Amours D. The Smc5/6 Core Complex Is a Structure-Specific DNA Binding and Compacting Machine. Mol Cell. 2020 12 17; 80(6):1025-1038.e5. PMID: 33301731.
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    27. Rouleau-Turcotte É, Pascal JM. Bridging a DNA Break to Leave a Poly(ADP-Ribose) Mark on Chromatin. Mol Cell. 2020 11 19; 80(4):560-561. PMID: 33217315.
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    28. Matsumoto Y, Brooks RC, Sverzhinsky A, Pascal JM, Tomkinson AE. Dynamic DNA-bound PCNA complexes co-ordinate Okazaki fragment synthesis, processing and ligation. J Mol Biol. 2020 Dec 04; 432(24):166698. PMID: 33157085.
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    29. Shao Z, Lee BJ, Rouleau-Turcotte É, Langelier MF, Lin X, Estes VM, Pascal JM, Zha S. Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo. Nucleic Acids Res. 2020 09 25; 48(17):9694-9709. PMID: 32890402.
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    30. Koirala S, Klein J, Zheng Y, Glenn NO, Eisemann T, Fon Tacer K, Miller DJ, Kulak O, Lu M, Finkelstein DB, Neale G, Tillman H, Vogel P, Strand DW, Lum L, Brautigam CA, Pascal JM, Clements WK, Potts PR. Tissue-Specific Regulation of the Wnt/ß-Catenin Pathway by PAGE4 Inhibition of Tankyrase. Cell Rep. 2020 Jul 21; 32(3):107922. PMID: 32698014.
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    31. Zandarashvili L, Langelier MF, Velagapudi UK, Hancock MA, Steffen JD, Billur R, Hannan ZM, Wicks AJ, Krastev DB, Pettitt SJ, Lord CJ, Talele TT, Pascal JM, Black BE. Structural basis for allosteric PARP-1 retention on DNA breaks. Science. 2020 04 03; 368(6486). PMID: 32241924.
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    32. Manenda MS, Picard MÈ, Zhang L, Cyr N, Zhu X, Barma J, Pascal JM, Couture M, Zhang C, Shi R. Structural analyses of the Group A flavin-dependent monooxygenase PieE reveal a sliding FAD cofactor conformation bridging OUT and IN conformations. J Biol Chem. 2020 Apr 03; 295(14):4709-4722. PMID: 32111738.
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    33. Eisemann T, Pascal JM. Poly(ADP-ribose) polymerase enzymes and the maintenance of genome integrity. Cell Mol Life Sci. 2020 Jan; 77(1):19-33. PMID: 31754726.
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    34. Eisemann T, Langelier MF, Pascal JM. Structural and functional analysis of parameters governing tankyrase-1 interaction with telomeric repeat-binding factor 1 and GDP-mannose dehydratase. J Biol Chem. 2019 Aug 02. PMID: 31375564.
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    35. Caron MC, Sharma AK, O'Sullivan J, Myler LR, Ferreira MT, Rodrigue A, Coulombe Y, Ethier C, Gagné JP, Langelier MF, Pascal JM, Finkelstein IJ, Hendzel MJ, Poirier GG, Masson JY. Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks. Nat Commun. 2019 Jul 04; 10(1):2954. PMID: 31273204.
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    36. Velagapudi UK, Langelier MF, Delgado-Martin C, Diolaiti ME, Bakker S, Ashworth A, Patel BA, Shao X, Pascal JM, Talele TT. Design and Synthesis of Poly(ADP-ribose) polymerase Inhibitors: Impact of Adenosine Pocket-Binding Motif Appendage to the 3-Oxo-2,3-dihydrobenzofuran-7-carboxamide on Potency and Selectivity. J Med Chem. 2019 May 01. PMID: 31042381.
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    37. Cohen-Armon M, Yeheskel A, Pascal JM. Signal-induced PARP1-Erk synergism mediates IEG expression. Signal Transduct Target Ther. 2019; 4:8. PMID: 30993015.
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    38. Langelier MF, Eisemann T, Riccio AA, Pascal JM. PARP family enzymes: regulation and catalysis of the poly(ADP-ribose) posttranslational modification. Curr Opin Struct Biol. 2018 12; 53:187-198. PMID: 30481609.
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    39. Pascal JM. The comings and goings of PARP-1 in response to DNA damage. DNA Repair (Amst). 2018 Aug 23. PMID: 30177435.
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    40. Gagné JP, Langelier MF, Pascal JM, Poirier GG. Hydrofluoric Acid-Based Derivatization Strategy To Profile PARP-1 ADP-Ribosylation by LC-MS/MS. J Proteome Res. 2018 Jul 06; 17(7):2542-2551. PMID: 29812941.
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    41. Langelier MF, Zandarashvili L, Aguiar PM, Black BE, Pascal JM. NAD+ analog reveals PARP-1 substrate-blocking mechanism and allosteric communication from catalytic center to DNA-binding domains. Nat Commun. 2018 02 27; 9(1):844. PMID: 29487285.
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    42. Karch KR, Langelier MF, Pascal JM, Garcia BA. The nucleosomal surface is the main target of histone ADP-ribosylation in response to DNA damage. Mol Biosyst. 2017 Nov 21; 13(12):2660-2671. PMID: 29058739.
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    43. Chand SN, Zarei M, Schiewer MJ, Kamath AR, Romeo C, Lal S, Cozzitorto JA, Nevler A, Scolaro L, Londin E, Jiang W, Meisner-Kober N, Pishvaian MJ, Knudsen KE, Yeo CJ, Pascal JM, Winter JM, Brody JR. Post-transcriptional regulation of PARG mRNA by HuR facilitates DNA repair and resistance to PARP inhibitors. Cancer Res. 2017 Jul 07. PMID: 28687616.
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    44. Kosek MN, Lee GO, Guerrant RL, Haque R, Kang G, Ahmed T, Bessong P, Ali A, Mduma E, Peñataro Yori P, Faubion WA, Lima AAM, Paredes Olortegui M, Mason C, Babji S, Singh R, Qureshi S, Kosek PS, Samie A, Pascal J, Shrestha S, McCormick BJJ, Seidman JC, Lang DR, Zaidi A, Caulfield LE, Gottlieb M. Age and Sex Normalization of Intestinal Permeability Measures for the Improved Assessment of Enteropathy in Infancy and Early Childhood: Results From the MAL-ED Study. J Pediatr Gastroenterol Nutr. 2017 07; 65(1):31-39. PMID: 28644347.
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    45. Sultanov DC, Gerasimova NS, Kudryashova KS, Maluchenko NV, Kotova EY, Langelier MF, Pascal JM, Kirpichnikov MP, Feofanov AV, Studitsky VM. Unfolding of core nucleosomes by PARP-1 revealed by spFRET microscopy. AIMS Genet. 2017; 4(1):21-31. PMID: 28804761.
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    46. Langelier MF, Steffen JD, Riccio AA, McCauley M, Pascal JM. Purification of DNA Damage-Dependent PARPs from E. coli for Structural and Biochemical Analysis. Methods Mol Biol. 2017; 1608:431-444. PMID: 28695525.
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    47. Lee GO, Richard SA, Kang G, Houpt ER, Seidman JC, Pendergast LL, Bhutta ZA, Ahmed T, Mduma ER, Lima AA, Bessong P, Jennifer MS, Hossain MI, Chandyo RK, Nyathi E, Lima IF, Pascal J, Soofi S, Ladaporn B, Guerrant RL, Caulfield LE, Black RE, Kosek MN. A Comparison of Diarrheal Severity Scores in the MAL-ED Multisite Community-Based Cohort Study. J Pediatr Gastroenterol Nutr. 2016 11; 63(5):466-473. PMID: 27347723.
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    48. Jeronimo C, Langelier MF, Bataille AR, Pascal JM, Pugh BF, Robert F. Tail and Kinase Modules Differently Regulate Core Mediator Recruitment and Function In Vivo. Mol Cell. 2016 Nov 03; 64(3):455-466. PMID: 27773677.
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    49. Eisemann T, McCauley M, Langelier MF, Gupta K, Roy S, Van Duyne GD, Pascal JM. Tankyrase-1 Ankyrin Repeats Form an Adaptable Binding Platform for Targets of ADP-Ribose Modification. Structure. 2016 Oct 4; 24(10):1679-1692. PMID: 27594684.
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    50. Steffen JD, McCauley MM, Pascal JM. Fluorescent sensors of PARP-1 structural dynamics and allosteric regulation in response to DNA damage. Nucleic Acids Res. 2016 Nov 16; 44(20):9771-9783. PMID: 27530425.
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    51. Riccio AA, McCauley M, Langelier MF, Pascal JM. Tankyrase Sterile a Motif Domain Polymerization Is Required for Its Role in Wnt Signaling. Structure. 2016 Sep 6; 24(9):1573-81. PMID: 27499439.
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    52. Riccio AA, Cingolani G, Pascal JM. PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage. Nucleic Acids Res. 2016 Feb 29; 44(4):1691-702. PMID: 26704974.
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    53. Eustermann S, Wu WF, Langelier MF, Yang JC, Easton LE, Riccio AA, Pascal JM, Neuhaus D. Structural Basis of Detection and Signaling of DNA Single-Strand Breaks by Human PARP-1. Mol Cell. 2015 Dec 3; 60(5):742-54. PMID: 26626479.
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    54. Dawicki-McKenna JM, Langelier MF, DeNizio JE, Riccio AA, Cao CD, Karch KR, McCauley M, Steffen JD, Black BE, Pascal JM. PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain. Mol Cell. 2015 Dec 3; 60(5):755-68. PMID: 26626480.
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    55. Chan TO, Zhang J, Tiegs BC, Blumhof B, Yan L, Keny N, Penny M, Li X, Pascal JM, Armen RS, Rodeck U, Penn RB. Akt kinase C-terminal modifications control activation loop dephosphorylation and enhance insulin response. Biochem J. 2015 Oct 1; 471(1):37-51. PMID: 26201515.
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    56. Pascal JM, Ellenberger T. The rise and fall of poly(ADP-ribose): An enzymatic perspective. DNA Repair (Amst). 2015 Aug; 32:10-6. PMID: 25963443.
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    57. Gagné JP, Ethier C, Defoy D, Bourassa S, Langelier MF, Riccio AA, Pascal JM, Moon KM, Foster LJ, Ning Z, Figeys D, Droit A, Poirier GG. Quantitative site-specific ADP-ribosylation profiling of DNA-dependent PARPs. DNA Repair (Amst). 2015 Jun; 30:68-79. PMID: 25800440.
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    58. Zhang M, Meng XY, Cui M, Pascal JM, Logothetis DE, Zhang JF. Selective phosphorylation modulates the PIP2 sensitivity of the CaM-SK channel complex. Nat Chem Biol. 2014 Sep; 10(9):753-9. PMID: 25108821.
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    59. Patel MR, Bhatt A, Steffen JD, Chergui A, Murai J, Pommier Y, Pascal JM, Trombetta LD, Fronczek FR, Talele TT. Discovery and Structure-Activity Relationship of Novel 2,3-Dihydrobenzofuran-7-carboxamide and 2,3-Dihydrobenzofuran-3(2H)-one-7-carboxamide Derivatives as Poly(ADP-ribose)polymerase-1 Inhibitors. J Med Chem. 2014 Jul 10; 57(13):5579-601. PMID: 24922587.
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    60. Langelier MF, Riccio AA, Pascal JM. PARP-2 and PARP-3 are selectively activated by 5' phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1. Nucleic Acids Res. 2014 Aug 1; 42(12):7762-75. PMID: 24928857.
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    61. Steffen JD, Brody JR, Armen RS, Pascal JM. Structural Implications for Selective Targeting of PARPs. Front Oncol. 2013; 3:301. PMID: 24392349.
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    62. Steffen JD, Tholey RM, Langelier MF, Planck JL, Schiewer MJ, Lal S, Bildzukewicz NA, Yeo CJ, Knudsen KE, Brody JR, Pascal JM. Targeting PARP-1 Allosteric Regulation Offers Therapeutic Potential against Cancer. Cancer Res. 2014 Jan 1; 74(1):31-7. PMID: 24189460.
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    63. Steffen JD, Pascal JM. New players to the field of ADP-ribosylation make the final cut. EMBO J. 2013 May 2; 32(9):1205-7. PMID: 23572078.
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    64. Zhang M, Pascal JM, Zhang JF. Unstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca2+-sensing and SK channel activation. Proc Natl Acad Sci U S A. 2013 Mar 19; 110(12):4828-33. PMID: 23487779.
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    65. Karlberg T, Langelier MF, Pascal JM, Schüler H. Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling. Mol Aspects Med. 2013 Dec; 34(6):1088-108. PMID: 23458732.
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    66. Langelier MF, Pascal JM. PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis. Curr Opin Struct Biol. 2013 Feb; 23(1):134-43. PMID: 23333033.
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    67. Schiewer MJ, Goodwin JF, Han S, Brenner JC, Augello MA, Dean JL, Liu F, Planck JL, Ravindranathan P, Chinnaiyan AM, McCue P, Gomella LG, Raj GV, Dicker AP, Brody JR, Pascal JM, Centenera MM, Butler LM, Tilley WD, Feng FY, Knudsen KE. Dual roles of PARP-1 promote cancer growth and progression. Cancer Discov. 2012 Dec; 2(12):1134-49. PMID: 22993403.
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    68. Langelier MF, Planck JL, Roy S, Pascal JM. Structural basis for DNA damage-dependent poly(ADP-ribosyl)ation by human PARP-1. Science. 2012 May 11; 336(6082):728-32. PMID: 22582261.
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    69. Zhang M, Abrams C, Wang L, Gizzi A, He L, Lin R, Chen Y, Loll PJ, Pascal JM, Zhang JF. Structural basis for calmodulin as a dynamic calcium sensor. Structure. 2012 May 9; 20(5):911-23. PMID: 22579256.
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    70. Chan TO, Pascal JM, Armen RS, Rodeck U. Autoregulation of kinase dephosphorylation by ATP binding in AGC protein kinases. Cell Cycle. 2012 Feb 1; 11(3):475-8. PMID: 22262182.
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    71. Zhang M, Pascal JM, Schumann M, Armen RS, Zhang JF. Identification of the functional binding pocket for compounds targeting small-conductance Ca²?-activated potassium channels. Nat Commun. 2012; 3:1021. PMID: 22929778.
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    72. Liu C, Sanders JM, Pascal JM, Hou YM. Adaptation to tRNA acceptor stem structure by flexible adjustment in the catalytic domain of class I tRNA synthetases. RNA. 2012 Feb; 18(2):213-21. PMID: 22184460.
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    73. Chan TO, Zhang J, Rodeck U, Pascal JM, Armen RS, Spring M, Dumitru CD, Myers V, Li X, Cheung JY, Feldman AM. Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):E1120-7. PMID: 22031698.
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    74. Langelier MF, Planck JL, Roy S, Pascal JM. Crystal structures of poly(ADP-ribose) polymerase-1 (PARP-1) zinc fingers bound to DNA: structural and functional insights into DNA-dependent PARP-1 activity. J Biol Chem. 2011 Mar 25; 286(12):10690-701. PMID: 21233213.
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    75. Langelier MF, Planck JL, Servent KM, Pascal JM. Purification of human PARP-1 and PARP-1 domains from Escherichia coli for structural and biochemical analysis. Methods Mol Biol. 2011; 780:209-26. PMID: 21870263.
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    76. Langelier MF, Ruhl DD, Planck JL, Kraus WL, Pascal JM. The Zn3 domain of human poly(ADP-ribose) polymerase-1 (PARP-1) functions in both DNA-dependent poly(ADP-ribose) synthesis activity and chromatin compaction. J Biol Chem. 2010 Jun 11; 285(24):18877-87. PMID: 20388712.
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    77. Song W, Pascal JM, Ellenberger T, Tomkinson AE. The DNA binding domain of human DNA ligase I interacts with both nicked DNA and the DNA sliding clamps, PCNA and hRad9-hRad1-hHus1. DNA Repair (Amst). 2009 Aug 6; 8(8):912-9. PMID: 19523882.
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    78. Pascal JM. DNA and RNA ligases: structural variations and shared mechanisms. Curr Opin Struct Biol. 2008 Feb; 18(1):96-105. PMID: 18262407.
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    79. Langelier MF, Servent KM, Rogers EE, Pascal JM. A third zinc-binding domain of human poly(ADP-ribose) polymerase-1 coordinates DNA-dependent enzyme activation. J Biol Chem. 2008 Feb 15; 283(7):4105-14. PMID: 18055453.
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    80. Pascal JM, Ellenberger T. RNA ligase does the AMP shuffle. Nat Struct Mol Biol. 2006 Nov; 13(11):950-1. PMID: 17082787.
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    81. Pascal JM, Tsodikov OV, Hura GL, Song W, Cotner EA, Classen S, Tomkinson AE, Tainer JA, Ellenberger T. A flexible interface between DNA ligase and PCNA supports conformational switching and efficient ligation of DNA. Mol Cell. 2006 Oct 20; 24(2):279-91. PMID: 17052461.
      Citations:    
    82. Tomkinson AE, Vijayakumar S, Pascal JM, Ellenberger T. DNA ligases: structure, reaction mechanism, and function. Chem Rev. 2006 Feb; 106(2):687-99. PMID: 16464020.
      Citations:    
    83. Chen X, Pascal J, Vijayakumar S, Wilson GM, Ellenberger T, Tomkinson AE. Human DNA ligases I, III, and IV-purification and new specific assays for these enzymes. Methods Enzymol. 2006; 409:39-52. PMID: 16793394.
      Citations:    
    84. Pascal JM, O'Brien PJ, Tomkinson AE, Ellenberger T. Human DNA ligase I completely encircles and partially unwinds nicked DNA. Nature. 2004 Nov 25; 432(7016):473-8. PMID: 15565146.
      Citations:    
    85. Pascal JM, Hart PJ, Hecht NB, Robertus JD. Crystal structure of TB-RBP, a novel RNA-binding and regulating protein. J Mol Biol. 2002 Jun 21; 319(5):1049-57. PMID: 12079346.
      Citations:    
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