Jing Chen-Roetling

TitleAsst Professor
InstitutionThomas Jefferson University
DepartmentEmergency Medicine
Address1020 Sansom St.
Philadelphia PA 19107
Phone215-955-6844
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Chen-Roetling J, Li Y, Cao Y, Yan Z, Lu X, Regan RF. Effect of hemopexin treatment on outcome after intracerebral hemorrhage in mice. Brain Res. 2021 Apr 28; 1765:147507. PMID: 33930375.
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    2. Chen-Roetling J, Cao Y, Peng D, Regan RF. Rapid Loss of Perihematomal Cell Viability in the Collagenase Intracerebral Hemorrhage Model. Brain Res. 2019 Jan 10. PMID: 30639124.
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    3. Chen-Roetling J, Regan KA, Regan RF. Protective effect of vitreous against hemoglobin neurotoxicity. Biochem Biophys Res Commun. 2018 Jun 06. PMID: 29859185.
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    4. Chen-Roetling J, Ma SK, Cao Y, Shah A, Regan RF. Hemopexin Increases the Neurotoxicity of Hemoglobin When Haptoglobin is Absent. J Neurochem. 2018 Mar 03. PMID: 29500821.
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    5. Chen-Roetling J, Kamalapathy P, Cao Y, Song W, Schipper HM, Regan RF. Astrocyte heme oxygenase-1 reduces mortality and improves outcome after collagenase-induced intracerebral hemorrhage. Neurobiol Dis. 2017 Jun; 102:140-146. PMID: 28323022.
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    6. Chen-Roetling J, Regan RF. Targeting the Nrf2-Heme Oxygenase-1 Axis after Intracerebral Hemorrhage. Curr Pharm Des. 2016 Oct 27. PMID: 27799046.
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    7. Chen-Roetling J, Regan RF. Haptoglobin increases the vulnerability of CD163-expressing neurons to hemoglobin. J Neurochem. 2016 Nov; 139(4):586-595. PMID: 27364920.
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    8. Chen-Roetling J, Song W, Schipper HM, Regan CS, Regan RF. Astrocyte overexpression of heme oxygenase-1 improves outcome after intracerebral hemorrhage. Stroke. 2015 Apr; 46(4):1093-8. PMID: 25690543.
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    9. Chen-Roetling J, Lu X, Regan RF. Targeting heme oxygenase after intracerebral hemorrhage. Ther Targets Neurol Dis. 2015 Jan 03; 2(1). PMID: 25642455.
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    10. Chen-Roetling J, Cai Y, Regan RF. Neuroprotective effect of heme oxygenase-2 knockout in the blood injection model of intracerebral hemorrhage. BMC Res Notes. 2014; 7(1):561. PMID: 25149897.
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    11. Lu X, Chen-Roetling J, Regan RF. Systemic hemin therapy attenuates blood-brain barrier disruption after intracerebral hemorrhage. Neurobiol Dis. 2014 Oct; 70:245-51. PMID: 24952361.
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    12. Chen-Roetling J, Cai Y, Lu X, Regan RF. Hemin uptake and release by neurons and glia. Free Radic Res. 2014 Feb; 48(2):200-5. PMID: 24164169.
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    13. Chen-Roetling J, Lu X, Regan KA, Regan RF. A rapid fluorescent method to quantify neuronal loss after experimental intracerebral hemorrhage. J Neurosci Methods. 2013 Jun 15; 216(2):128-36. PMID: 23583700.
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    14. Chen-Roetling J, Sinanan J, Regan RF. Effect of iron chelators on methemoglobin and thrombin preconditioning. Transl Stroke Res. 2012 Dec; 3(4):452-9. PMID: 23585819.
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    15. Chen-Roetling J, Liu W, Regan RF. Hemopexin decreases hemin accumulation and catabolism by neural cells. Neurochem Int. 2012 Apr; 60(5):488-94. PMID: 22342655.
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    16. Chen-Roetling J, Liu W, Regan RF. Iron accumulation and neurotoxicity in cortical cultures treated with holotransferrin. Free Radic Biol Med. 2011 Dec 1; 51(11):1966-74. PMID: 21939754.
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    17. Chen L, Zhang X, Chen-Roetling J, Regan RF. Increased striatal injury and behavioral deficits after intracerebral hemorrhage in hemopexin knockout mice. J Neurosurg. 2011 Apr; 114(4):1159-67. PMID: 21128737.
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    18. Chen-Roetling J, Chen L, Regan RF. Apotransferrin protects cortical neurons from hemoglobin toxicity. Neuropharmacology. 2011 Feb-Mar; 60(2-3):423-31. PMID: 21034753.
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    19. Jaremko KM, Chen-Roetling J, Chen L, Regan RF. Accelerated hemolysis and neurotoxicity in neuron-glia-blood clot co-cultures. J Neurochem. 2010 Aug; 114(4):1063-73. PMID: 20497302.
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    20. Chen M, Awe OO, Chen-Roetling J, Regan RF. Iron regulatory protein-2 knockout increases perihematomal ferritin expression and cell viability after intracerebral hemorrhage. Brain Res. 2010 Jun 14; 1337:95-103. PMID: 20399759.
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    21. Chen-Roetling J, Chen L, Regan RF. Minocycline attenuates iron neurotoxicity in cortical cell cultures. Biochem Biophys Res Commun. 2009 Aug 21; 386(2):322-6. PMID: 19523448.
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    22. Li Z, Chen-Roetling J, Regan RF. Increasing expression of H- or L-ferritin protects cortical astrocytes from hemin toxicity. Free Radic Res. 2009 Jun; 43(6):613-21. PMID: 19513908.
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    23. Chen-Roetling J, Li Z, Chen M, Awe OO, Regan RF. Heme oxygenase activity and hemoglobin neurotoxicity are attenuated by inhibitors of the MEK/ERK pathway. Neuropharmacology. 2009 Apr; 56(5):922-8. PMID: 19371583.
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    24. Chen-Roetling J, Li Z, Regan RF. Hemoglobin neurotoxicity is attenuated by inhibitors of the protein kinase CK2 independent of heme oxygenase activity. Curr Neurovasc Res. 2008 Aug; 5(3):193-8. PMID: 18691077.
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    25. Regan RF, Li Z, Chen M, Zhang X, Chen-Roetling J. Iron regulatory proteins increase neuronal vulnerability to hydrogen peroxide. Biochem Biophys Res Commun. 2008 Oct 10; 375(1):6-10. PMID: 18655771.
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    26. Regan RF, Chen M, Li Z, Zhang X, Benvenisti-Zarom L, Chen-Roetling J. Neurons lacking iron regulatory protein-2 are highly resistant to the toxicity of hemoglobin. Neurobiol Dis. 2008 Aug; 31(2):242-9. PMID: 18571425.
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    27. Qu Y, Chen-Roetling J, Benvenisti-Zarom L, Regan RF. Attenuation of oxidative injury after induction of experimental intracerebral hemorrhage in heme oxygenase-2 knockout mice. J Neurosurg. 2007 Mar; 106(3):428-35. PMID: 17367065.
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    28. Chen-Roetling J, Regan RF. Effect of heme oxygenase-1 on the vulnerability of astrocytes and neurons to hemoglobin. Biochem Biophys Res Commun. 2006 Nov 10; 350(1):233-7. PMID: 16999934.
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    29. Benvenisti-Zarom L, Chen-Roetling J, Regan RF. Inhibition of the ERK/MAP kinase pathway attenuates heme oxygenase-1 expression and heme-mediated neuronal injury. Neurosci Lett. 2006 May 8; 398(3):230-4. PMID: 16443326.
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    30. Chen-Roetling J, Benvenisti-Zarom L, Regan RF. Cultured astrocytes from heme oxygenase-1 knockout mice are more vulnerable to heme-mediated oxidative injury. J Neurosci Res. 2005 Dec 15; 82(6):802-10. PMID: 16273550.
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