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Babatunde A Ogunnaike

TitleInterim Dean
InstitutionUniversity of Delaware
DepartmentCollege of Engineering
Phone302-831-4504
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    Other Positions
    TitleWilliam L. Friend Chaired Professor
    InstitutionUniversity of Delaware
    DepartmentChemical and Biomolecular Engineering

    TitleProfessor
    InstitutionUniversity of Delaware
    DepartmentDelaware Biotechnology Institute (DBI)


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Luo Y, Lovelett RJ, Price JV, Radhakrishnan D, Barnthouse K, Hu P, Schaefer E, Cunningham J, Lee KH, Shivappa RB, Ogunnaike BA. Modeling the Effect of Amino Acids and Copper on Monoclonal Antibody Productivity and Glycosylation: A Modular Approach. Biotechnol J. 2020 Sep 01; e2000261. PMID: 32875683.
      View in: PubMed
    2. Wells E, Song L, Greer M, Luo Y, Kurian V, Ogunnaike B, Robinson AS. Media supplementation for targeted manipulation of monoclonal antibody galactosylation and fucosylation. Biotechnol Bioeng. 2020 Jul 14. PMID: 32662879.
      View in: PubMed
    3. Zhang Q, Shan KS, Ogunnaike BA, Amewuame-Kpehor A, Nace T. An Exceedingly Rare Presentation of Severe Folate Deficiency-Induced Non-Immune Hemolytic Anemia. Cureus. 2020 Jun 11; 12(6):e8570. PMID: 32670706.
      View in: PubMed
    4. Park JH, Gorky J, Ogunnaike B, Vadigepalli R, Schwaber JS. Investigating the Effects of Brainstem Neuronal Adaptation on Cardiovascular Homeostasis. Front Neurosci. 2020; 14:470. PMID: 32508573.
      View in: PubMed
    5. Staehle MM, O'Sullivan S, Vadigepalli R, Kernan KF, Gonye GE, Ogunnaike BA, Schwaber JS. Diurnal Patterns of Gene Expression in the Dorsal Vagal Complex and the Central Nucleus of the Amygdala - Non-rhythm-generating Brain Regions. Front Neurosci. 2020; 14:375. PMID: 32477043.
      View in: PubMed
    6. McIlvain G, Ganji E, Cooper C, Killian ML, Ogunnaike BA, Johnson CL. Reliable preparation of agarose phantoms for use in quantitative magnetic resonance elastography. J Mech Behav Biomed Mater. 2019 Sep; 97:65-73. PMID: 31100487.
      View in: PubMed
    7. Verma A, Antony AN, Ogunnaike BA, Hoek JB, Vadigepalli R. Causality Analysis and Cell Network Modeling of Spatial Calcium Signaling Patterns in Liver Lobules. Front Physiol. 2018; 9:1377. PMID: 30337879.
      View in: PubMed
    8. Cook D, Achanta S, Hoek JB, Ogunnaike BA, Vadigepalli R. Cellular network modeling and single cell gene expression analysis reveals novel hepatic stellate cell phenotypes controlling liver regeneration dynamics. BMC Syst Biol. 2018 Oct 03; 12(1):86. PMID: 30285726.
      View in: PubMed
    9. Radhakrishnan D, Robinson AS, Ogunnaike BA. Controlling the Glycosylation Profile in mAbs Using Time-Dependent Media Supplementation. Antibodies (Basel). 2017 Dec 21; 7(1). PMID: 31544854.
      View in: PubMed
    10. Park J, Zhu H, O'Sullivan S, Ogunnaike BA, Weaver DR, Schwaber JS, Vadigepalli R. Single-Cell Transcriptional Analysis Reveals Novel Neuronal Phenotypes and Interaction Networks Involved in the Central Circadian Clock. Front Neurosci. 2016; 10:481. PMID: 27826225.
      View in: PubMed
    11. St Amand MM, Hayes J, Radhakrishnan D, Fernandez J, Meyer B, Robinson AS, Ogunnaike BA. Identifying a robust design space for glycosylation during monoclonal antibody production. Biotechnol Prog. 2016 Sep; 32(5):1149-1162. PMID: 27273898.
      View in: PubMed
    12. Verma A, Makadia H, Hoek JB, Ogunnaike BA, Vadigepalli R. Computational Modeling of Spatiotemporal Ca(2+) Signal Propagation Along Hepatocyte Cords. IEEE Trans Biomed Eng. 2016 Oct; 63(10):2047-55. PMID: 27076052.
      View in: PubMed
    13. Cook D, Ogunnaike BA, Vadigepalli R. Systems analysis of non-parenchymal cell modulation of liver repair across multiple regeneration modes. BMC Syst Biol. 2015; 9(1):71. PMID: 26493454.
      View in: PubMed
    14. Correnti JM, Cook D, Aksamitiene E, Swarup A, Ogunnaike B, Vadigepalli R, Hoek JB. Adiponectin fine-tuning of liver regeneration dynamics revealed through cellular network modelling. J Physiol. 2015 Jan 15; 593(2):365-83. PMID: 25630259.
      View in: PubMed
    15. Park J, Ogunnaike B, Schwaber J, Vadigepalli R. Identifying functional gene regulatory network phenotypes underlying single cell transcriptional variability. Prog Biophys Mol Biol. 2015 Jan; 117(1):87-98. PMID: 25433230.
      View in: PubMed
    16. St Amand MM, Radhakrishnan D, Robinson AS, Ogunnaike BA. Identification of manipulated variables for a glycosylation control strategy. Biotechnol Bioeng. 2014 Oct; 111(10):1957-70. PMID: 24728980.
      View in: PubMed
    17. Christie CR, Achenie LE, Ogunnaike BA. A control engineering model of calcium regulation. J Clin Endocrinol Metab. 2014 Aug; 99(8):2844-53. PMID: 24731009.
      View in: PubMed
    18. Park J, Brureau A, Kernan K, Starks A, Gulati S, Ogunnaike B, Schwaber J, Vadigepalli R. Inputs drive cell phenotype variability. Genome Res. 2014 Jun; 24(6):930-41. PMID: 24671852.
      View in: PubMed
    19. St Amand MM, Tran K, Radhakrishnan D, Robinson AS, Ogunnaike BA. Controllability analysis of protein glycosylation in cho cells. PLoS One. 2014; 9(2):e87973. PMID: 24498415.
      View in: PubMed
    20. Welf ES, Naik UP, Ogunnaike BA. A spatial model for integrin clustering as a result of feedback between integrin activation and integrin binding. Biophys J. 2012 Sep 19; 103(6):1379-89. PMID: 22995511.
      View in: PubMed
    21. Birtwistle MR, Rauch J, Kiyatkin A, Aksamitiene E, Dobrzynski M, Hoek JB, Kolch W, Ogunnaike BA, Kholodenko BN. Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise. BMC Syst Biol. 2012; 6:109. PMID: 22920937.
      View in: PubMed
    22. Freeman K, Staehle MM, Vadigepalli R, Gonye GE, Ogunnaike BA, Hoek JB, Schwaber JS. Coordinated dynamic gene expression changes in the central nucleus of the amygdala during alcohol withdrawal. Alcohol Clin Exp Res. 2013 Jan; 37 Suppl 1:E88-E100. PMID: 22827539.
      View in: PubMed
    23. Freeman K, Staehle MM, Gümüs ZH, Vadigepalli R, Gonye GE, Nichols CN, Ogunnaike BA, Hoek JB, Schwaber JS. Rapid temporal changes in the expression of a set of neuromodulatory genes during alcohol withdrawal in the dorsal vagal complex: molecular evidence of homeostatic disturbance. Alcohol Clin Exp Res. 2012 Oct; 36(10):1688-700. PMID: 22486438.
      View in: PubMed
    24. Chung SW, Cooper CR, Farach-Carson MC, Ogunnaike BA. A control engineering approach to understanding the TGF-ß paradox in cancer. J R Soc Interface. 2012 Jun 7; 9(71):1389-97. PMID: 22188767.
      View in: PubMed
    25. Welf ES, Naik UP, Ogunnaike BA. Probabilistic modeling and analysis of the effects of extra-cellular matrix density on the sizes, shapes, and locations of integrin clusters in adherent cells. BMC Biophys. 2011; 4:15. PMID: 21827670.
      View in: PubMed
    26. Miller GM, Ogunnaike BA, Schwaber JS, Vadigepalli R. Robust dynamic balance of AP-1 transcription factors in a neuronal gene regulatory network. BMC Syst Biol. 2010; 4:171. PMID: 21167049.
      View in: PubMed
    27. Nakakuki T, Birtwistle MR, Saeki Y, Yumoto N, Ide K, Nagashima T, Brusch L, Ogunnaike BA, Okada-Hatakeyama M, Kholodenko BN. Ligand-specific c-Fos expression emerges from the spatiotemporal control of ErbB network dynamics. Cell. 2010 May 28; 141(5):884-96. PMID: 20493519.
      View in: PubMed
    28. Ogunnaike BA, Gelmi CA, Edwards JS. A probabilistic framework for microarray data analysis: fundamental probability models and statistical inference. J Theor Biol. 2010 May 21; 264(2):211-22. PMID: 20170665.
      View in: PubMed
    29. Li Y, Ogunnaike BA, Roberts CJ. Multi-variate approach to global protein aggregation behavior and kinetics: effects of pH, NaCl, and temperature for alpha-chymotrypsinogen A. J Pharm Sci. 2010 Feb; 99(2):645-62. PMID: 19653264.
      View in: PubMed
    30. Chung SW, Miles FL, Sikes RA, Cooper CR, Farach-Carson MC, Ogunnaike BA. Quantitative modeling and analysis of the transforming growth factor beta signaling pathway. Biophys J. 2009 Mar 4; 96(5):1733-50. PMID: 19254534.
      View in: PubMed
    31. Birtwistle MR, Hatakeyama M, Yumoto N, Ogunnaike BA, Hoek JB, Kholodenko BN. Ligand-dependent responses of the ErbB signaling network: experimental and modeling analyses. Mol Syst Biol. 2007; 3:144. PMID: 18004277.
      View in: PubMed
    32. Tendulkar AV, Ogunnaike B, Wangikar PP. Protein local conformations arise from a mixture of Gaussian distributions. J Biosci. 2007 Aug; 32(5):899-908. PMID: 17914232.
      View in: PubMed
    33. Samant A, Ogunnaike BA, Vlachos DG. A hybrid multiscale Monte Carlo algorithm (HyMSMC) to cope with disparity in time scales and species populations in intracellular networks. BMC Bioinformatics. 2007; 8:175. PMID: 17524148.
      View in: PubMed
    34. Ogunnaike BA. Elucidating the digital control mechanism for DNA damage repair with the p53-Mdm2 system: single cell data analysis and ensemble modelling. J R Soc Interface. 2006 Feb 22; 3(6):175-84. PMID: 16849229.
      View in: PubMed
    35. Kauffman KJ, Ogunnaike BA, Edwards JS. Designing experiments that aid in the identification of regulatory networks. Brief Funct Genomic Proteomic. 2006 Feb; 4(4):331-42. PMID: 17202124.
      View in: PubMed
    36. Zak DE, Hao H, Vadigepalli R, Miller GM, Ogunnaike BA, Schwaber JS. Systems analysis of circadian time-dependent neuronal epidermal growth factor receptor signaling. Genome Biol. 2006; 7(6):R48. PMID: 16784547.
      View in: PubMed
    37. Hao H, Zak DE, Sauter T, Schwaber J, Ogunnaike BA. Modeling the VPAC2-activated cAMP/PKA signaling pathway: from receptor to circadian clock gene induction. Biophys J. 2006 Mar 1; 90(5):1560-71. PMID: 16339878.
      View in: PubMed
    38. Merritt J, Butz JA, Ogunnaike BA, Edwards JS. Parallel analysis of mutant human glucose 6-phosphate dehydrogenase in yeast using PCR colonies. Biotechnol Bioeng. 2005 Dec 5; 92(5):519-31. PMID: 16193512.
      View in: PubMed
    39. Mikkilineni V, Mitra RD, Merritt J, DiTonno JR, Church GM, Ogunnaike B, Edwards JS. Digital quantitative measurements of gene expression. Biotechnol Bioeng. 2004 Apr 20; 86(2):117-24. PMID: 15052631.
      View in: PubMed
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