Thomas Jefferson University

Kishore Alugupalli

TitleAdjunct Faculty
InstitutionPhiladelphia University
DepartmentJefferson Institute of Bioproc
Address727 Norristown Road
Lower Gwynedd PA 19107
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    R01AI065750     (ALUGUPALLI, KISHORE R)Jul 15, 2006 - Jun 30, 2012
    NIH
    B1B lymphocytes generate T cell-independent memory
    Role: Principal Investigator
    R56AI097421     (ALUGUPALLI, KISHORE R)Aug 15, 2012 - Jul 31, 2014
    NIH
    Toll-like receptor signaling in the generation of B1b cell memory
    Role: Principal Investigator
    R03AI105724     (ALUGUPALLI, KISHORE R)Jan 1, 2014 - Dec 31, 2016
    NIH
    Induction of polysaccharide vaccine responses in the young by interleukin-7
    Role: Principal Investigator
    R03AI112624     (ALUGUPALLI, KISHORE R)Jun 1, 2014 - May 31, 2017
    NIH
    B1 cell-mediated immunity in Human Immune System mice
    Role: Principal Investigator
    R03AI109217     (ALUGUPALLI, KISHORE R)Aug 1, 2014 - Jul 31, 2017
    NIH
    Role of BAFFR in antigen-specific B1b cell persistence
    Role: Principal Investigator
    R03AI115412     (ALUGUPALLI, KISHORE R)Dec 1, 2014 - Nov 30, 2017
    NIH
    Toll-like receptor signaling in B1b memory
    Role: Principal Investigator
    R56AI121270     (ALUGUPALLI, KISHORE R)Aug 22, 2016 - Jul 31, 2019
    NIH
    Regulation of bacterial polysaccharide-specific B cell responses
    Role: Principal Investigator
    R21AI133075     (MANSER, TIMOTHY L)Jun 5, 2017 - May 31, 2021
    NIH
    Effect of IL-7 on B cell development and function in humanized mice
    Role: Co-Principal Investigator
    R21AI151737     (MANSER, TIMOTHY L)May 5, 2020 - Apr 30, 2022
    NIH
    Stem cell origins of human fetal/neonatal B cell subsets
    Role: Co-Principal Investigator
    R21AI159798     (ALUGUPALLI, KISHORE R)Mar 1, 2021 - Feb 29, 2024
    NIH
    A System to Study Salmonella Typhi Infection and Immunity
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Alugupalli KR. Characterization of Turbo, a TLR Ligand-based Adjuvant for Glycoconjugate Vaccines. Immunohorizons. 2024 Aug 01; 8(8):527-537. PMID: 39093309.
      Citations:    
    2. Alugupalli KR. A TLR4 ligand-based adjuvant for promoting the immunogenicity of typhoid subunit vaccines. Front Immunol. 2024; 15:1383476. PMID: 38799439.
      Citations:    
    3. Alugupalli KR. Monophosphoryl Lipid A-based Adjuvant to Promote the Immunogenicity of Multivalent Meningococcal Polysaccharide Conjugate Vaccines. Immunohorizons. 2024 Apr 01; 8(4):317-325. PMID: 38625118.
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    4. Alugupalli KR. TLR4 Ligands in Typhoid Vi Polysaccharide Subunit Vaccines Contribute to Immunogenicity. Immunohorizons. 2024 Jan 01; 8(1):29-34. PMID: 38180344.
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    5. Alugupalli KR, Kothari S, Cravens MP, Walker JA, Dougharty DT, Dickinson GS, Gatto LA, B?umler AJ, Wangdi T, Miller DR, Pardo-Manuel de Villena F, Siracusa LD. Identification of collaborative cross mouse strains permissive to Salmonella enterica serovar Typhi infection. Sci Rep. 2023 Jan 09; 13(1):393. PMID: 36624251.
      Citations:    
    6. Alugupalli AS, Cravens MP, Walker JA, Gulandijany D, Dickinson GS, Debes GF, Schifferli DM, B?umler AJ, Alugupalli KR. The Lack of Natural IgM Increases Susceptibility and Impairs Anti-Vi Polysaccharide IgG Responses in a Mouse Model of Typhoid. Immunohorizons. 2022 12 01; 6(12):807-816. PMID: 36480484.
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    7. Cravens MP, Alugupalli AS, Sandilya VK, McGeady SJ, Alugupalli KR. The Immunoglobulin M Response to Pneumococcal Polysaccharide Vaccine Is Sufficient for Conferring Immunity. J Infect Dis. 2022 11 11; 226(10):1852-1856. PMID: 35932228.
      Citations:    
    8. Cheng M, Xu J, Ding K, Zhang J, Lu W, Liu J, Gao J, Alugupalli KR, Liu H. Attenuation of relapsing fever neuroborreliosis in mice by IL-17A blockade. Proc Natl Acad Sci U S A. 2022 10 18; 119(42):e2205460119. PMID: 36215473.
      Citations:    
    9. Dickinson GS, Levenson EA, Walker JA, Kearney JF, Alugupalli KR. IL-7 Enables Antibody Responses to Bacterial Polysaccharides by Promoting B Cell Receptor Diversity. J Immunol. 2018 Aug 15; 201(4):1229-1240. PMID: 30006375.
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    10. Belde V, Cravens M, Gulandijany D, Walker JA, Palomo-Caturla I, Alugupalli AS, Sandilya V, Mahmoud T, Bäumler AJ, Kearney JF, Alugupalli KR. Terminal deoxynucleotidyl Transferase is not required for antibody response to polysaccharide vaccines against Streptococcus pneumoniae and Salmonella Typhi. Infect Immun. 2018 Jul 02. PMID: 29967094.
      Citations:    
    11. Pandya KD, Palomo-Caturla I, Walker JA, K Sandilya V, Zhong Z, Alugupalli KR. An Unmutated IgM Response to the Vi Polysaccharide of Salmonella Typhi Contributes to Protective Immunity in a Murine Model of Typhoid. J Immunol. 2018 Jun 15; 200(12):4078-4084. PMID: 29743315.
      Citations:    
    12. Walker JA, Vuyyuru R, Manser T, Alugupalli KR. Humoral Immunity in Mice Transplanted with Hematopoietic Stem Cells Derived from Human Umbilical Cord Blood Recapitulates That of Human Infants. Stem Cells Dev. 2017 Dec 01; 26(23):1715-1723. PMID: 29099340.
      Citations:    
    13. Haley SL, Tzvetkov EP, Lytle AG, Alugupalli KR, Plummer JR, McGettigan JP. APRIL:TACI axis is dispensable for the immune response to rabies vaccination. Antiviral Res. 2017 Jun 12; 144:130-137. PMID: 28619678.
      Citations:    
    14. Dickinson GS, Akkoyunlu M, Bram RJ, Alugupalli KR. BAFF receptor and TACI in B-1b cell maintenance and antibacterial responses. Ann N Y Acad Sci. 2015 Dec; 1362(1):57-67. PMID: 25962322.
      Citations:    
    15. Uslu K, Coleman AS, Allman WR, Katsenelson N, Bram RJ, Alugupalli KR, Akkoyunlu M. Impaired B Cell Receptor Signaling Is Responsible for Reduced TACI Expression and Function in X-Linked Immunodeficient Mice. J Immunol. 2014 Apr 15; 192(8):3582-95. PMID: 24646744.
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    16. Dickinson GS, Sun G, Bram RJ, Alugupalli KR. Efficient B Cell Responses to Borrelia hermsii Infection Depend on BAFF and BAFFR but Not TACI. Infect Immun. 2014 Jan; 82(1):453-9. PMID: 24218480.
      Citations:    
    17. Dickinson GS, Alugupalli KR. Deciphering the role of Toll-like receptors in humoral responses to Borreliae. Front Biosci (Schol Ed). 2012; 4:699-712. PMID: 22202086.
      Citations:    
    18. Vuyyuru R, Liu H, Manser T, Alugupalli KR. Characteristics of Borrelia hermsii infection in human hematopoietic stem cell-engrafted mice mirror those of human relapsing fever. Proc Natl Acad Sci U S A. 2011 Dec 20; 108(51):20707-12. PMID: 22143787.
      Citations:    
    19. Colombo MJ, Abraham D, Shibuya A, Alugupalli KR. B1b lymphocyte-derived antibodies control Borrelia hermsii independent of Fca/µ receptor and in the absence of host cell contact. Immunol Res. 2011 Dec; 51(2-3):249-56. PMID: 22139824.
      Citations:    
    20. Dickinson GS, Piccone H, Sun G, Lien E, Gatto L, Alugupalli KR. Toll-like receptor 2 deficiency results in impaired antibody responses and septic shock during Borrelia hermsii infection. Infect Immun. 2010 Nov; 78(11):4579-88. PMID: 20696824.
      Citations:    
    21. Colombo MJ, Sun G, Alugupalli KR. T-cell-independent immune responses do not require CXC ligand 13-mediated B1 cell migration. Infect Immun. 2010 Sep; 78(9):3950-6. PMID: 20584971.
      Citations:    
    22. Shriner AK, Liu H, Sun G, Guimond M, Alugupalli KR. IL-7-dependent B lymphocytes are essential for the anti-polysaccharide response and protective immunity to Streptococcus pneumoniae. J Immunol. 2010 Jul 1; 185(1):525-31. PMID: 20505146.
      Citations:    
    23. Liu H, Fitzgerald D, Gran B, Leong JM, Alugupalli KR. Induction of distinct neurologic disease manifestations during relapsing fever requires T lymphocytes. J Immunol. 2010 May 15; 184(10):5859-64. PMID: 20382883.
      Citations:    
    24. Benoit VM, Petrich A, Alugupalli KR, Marty-Roix R, Moter A, Leong JM, Boyartchuk VL. Genetic control of the innate immune response to Borrelia hermsii influences the course of relapsing fever in inbred strains of mice. Infect Immun. 2010 Feb; 78(2):586-94. PMID: 19995898.
      Citations:    
    25. Faber M, Li J, Kean RB, Hooper DC, Alugupalli KR, Dietzschold B. Effective preexposure and postexposure prophylaxis of rabies with a highly attenuated recombinant rabies virus. Proc Natl Acad Sci U S A. 2009 Jul 7; 106(27):11300-5. PMID: 19581599.
      Citations:    
    26. Alugupalli KR, Abraham D. B cell multitasking is required to control nematode infection. Immunity. 2009 Mar 20; 30(3):317-9. PMID: 19303384.
      Citations:    
    27. Colombo MJ, Alugupalli KR. Complement factor H-binding protein, a putative virulence determinant of Borrelia hermsii, is an antigenic target for protective B1b lymphocytes. J Immunol. 2008 Apr 1; 180(7):4858-64. PMID: 18354209.
      Citations:    
    28. O'Brien K, Fitzgerald DC, Naiken K, Alugupalli KR, Rostami AM, Gran B. Role of the innate immune system in autoimmune inflammatory demyelination. Curr Med Chem. 2008; 15(11):1105-15. PMID: 18473806.
      Citations:    
    29. Alugupalli KR. A distinct role for B1b lymphocytes in T cell-independent immunity. Curr Top Microbiol Immunol. 2008; 319:105-30. PMID: 18080416.
      Citations:    
    30. Wong SM, Alugupalli KR, Ram S, Akerley BJ. The ArcA regulon and oxidative stress resistance in Haemophilus influenzae. Mol Microbiol. 2007 Jun; 64(5):1375-90. PMID: 17542927.
      Citations:    
    31. Alugupalli KR, Akira S, Lien E, Leong JM. MyD88- and Bruton's tyrosine kinase-mediated signals are essential for T cell-independent pathogen-specific IgM responses. J Immunol. 2007 Mar 15; 178(6):3740-9. PMID: 17339472.
      Citations:    
    32. Alugupalli KR, Gerstein RM. Divide and conquer: division of labor by B-1 B cells. Immunity. 2005 Jul; 23(1):1-2. PMID: 16039572.
      Citations:    
    33. Alugupalli KR, Leong JM, Woodland RT, Muramatsu M, Honjo T, Gerstein RM. B1b lymphocytes confer T cell-independent long-lasting immunity. Immunity. 2004 Sep; 21(3):379-90. PMID: 15357949.
      Citations:    
    34. Alugupalli KR, Michelson AD, Joris I, Schwan TG, Hodivala-Dilke K, Hynes RO, Leong JM. Spirochete-platelet attachment and thrombocytopenia in murine relapsing fever borreliosis. Blood. 2003 Oct 15; 102(8):2843-50. PMID: 12855586.
      Citations:    
    35. Alugupalli KR, Gerstein RM, Chen J, Szomolanyi-Tsuda E, Woodland RT, Leong JM. The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes. J Immunol. 2003 Apr 1; 170(7):3819-27. PMID: 12646649.
      Citations:    
    36. Alugupalli KR, Michelson AD, Barnard MR, Leong JM. Serial determinations of platelet counts in mice by flow cytometry. Thromb Haemost. 2001 Aug; 86(2):668-71. PMID: 11522020.
      Citations:    
    37. Alugupalli KR, Michelson AD, Barnard MR, Robbins D, Coburn J, Baker EK, Ginsberg MH, Schwan TG, Leong JM. Platelet activation by a relapsing fever spirochaete results in enhanced bacterium-platelet interaction via integrin alphaIIbbeta3 activation. Mol Microbiol. 2001 Jan; 39(2):330-40. PMID: 11136454.
      Citations:    
    38. Magoun L, Zückert WR, Robbins D, Parveen N, Alugupalli KR, Schwan TG, Barbour AG, Leong JM. Variable small protein (Vsp)-dependent and Vsp-independent pathways for glycosaminoglycan recognition by relapsing fever spirochaetes. Mol Microbiol. 2000 May; 36(4):886-97. PMID: 10844676.
      Citations:    
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