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Kishore Alugupalli

TitleAssoc Professor
InstitutionThomas Jefferson University
DepartmentMicrobiology
Phone215-503-4554
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    Collapse Research 
    Collapse research activities and funding
    R01AI065750     (ALUGUPALLI, KISHORE R)Jul 15, 2006 - Jun 30, 2012
    NIH/NIAID
    B1B lymphocytes generate T cell-independent memory
    Role: Principal Investigator

    R56AI097421     (ALUGUPALLI, KISHORE R)Aug 15, 2012 - Jul 31, 2014
    NIH/NIAID
    Toll-like receptor signaling in the generation of B1b cell memory
    Role: Principal Investigator

    R03AI105724     (ALUGUPALLI, KISHORE R)Jan 1, 2014 - Dec 31, 2015
    NIH/NIAID
    Induction of polysaccharide vaccine responses in the young by interleukin-7
    Role: Principal Investigator

    R03AI112624     (ALUGUPALLI, KISHORE R)Jun 1, 2014 - May 31, 2016
    NIH/NIAID
    B1 cell-mediated immunity in Human Immune System mice
    Role: Principal Investigator

    R03AI109217     (ALUGUPALLI, KISHORE R)Aug 1, 2014 - Jul 31, 2016
    NIH/NIAID
    Role of BAFFR in antigen-specific B1b cell persistence
    Role: Principal Investigator

    R03AI115412     (ALUGUPALLI, KISHORE R)Dec 1, 2014 - Nov 30, 2016
    NIH/NIAID
    Toll-like receptor signaling in B1b memory
    Role: Principal Investigator

    R56AI121270     (ALUGUPALLI, KISHORE R)Aug 22, 2016 - Jul 31, 2017
    NIH/NIAID
    Regulation of bacterial polysaccharide-specific B cell responses
    Role: Principal Investigator

    R21AI133075     (MANSER, TIMOTHY L)Jun 5, 2017 - May 31, 2019
    NIH/NIAID
    Effect of IL-7 on B cell development and function in humanized mice
    Role: Co-Principal Investigator

    R21AI151737     (MANSER, TIMOTHY L)May 5, 2020 - Apr 30, 2022
    NIH/NIAID
    Stem cell origins of human fetal/neonatal B cell subsets
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Dickinson GS, Levenson EA, Walker JA, Kearney JF, Alugupalli KR. IL-7 Enables Antibody Responses to Bacterial Polysaccharides by Promoting B Cell Receptor Diversity. J Immunol. 2018 Aug 15; 201(4):1229-1240. PMID: 30006375.
      View in: PubMed
    2. Belde V, Cravens M, Gulandijany D, Walker JA, Palomo-Caturla I, Alugupalli AS, Sandilya V, Mahmoud T, Bäumler AJ, Kearney JF, Alugupalli KR. Terminal deoxynucleotidyl Transferase is not required for antibody response to polysaccharide vaccines against Streptococcus pneumoniae and Salmonella Typhi. Infect Immun. 2018 Jul 02. PMID: 29967094.
      View in: PubMed
    3. Pandya KD, Palomo-Caturla I, Walker JA, K Sandilya V, Zhong Z, Alugupalli KR. An Unmutated IgM Response to the Vi Polysaccharide of Salmonella Typhi Contributes to Protective Immunity in a Murine Model of Typhoid. J Immunol. 2018 Jun 15; 200(12):4078-4084. PMID: 29743315.
      View in: PubMed
    4. Walker JA, Vuyyuru R, Manser T, Alugupalli KR. Humoral Immunity in Mice Transplanted with Hematopoietic Stem Cells Derived from Human Umbilical Cord Blood Recapitulates That of Human Infants. Stem Cells Dev. 2017 Dec 01; 26(23):1715-1723. PMID: 29099340.
      View in: PubMed
    5. Haley SL, Tzvetkov EP, Lytle AG, Alugupalli KR, Plummer JR, McGettigan JP. APRIL:TACI axis is dispensable for the immune response to rabies vaccination. Antiviral Res. 2017 Jun 12; 144:130-137. PMID: 28619678.
      View in: PubMed
    6. Dickinson GS, Akkoyunlu M, Bram RJ, Alugupalli KR. BAFF receptor and TACI in B-1b cell maintenance and antibacterial responses. Ann N Y Acad Sci. 2015 Dec; 1362(1):57-67. PMID: 25962322.
      View in: PubMed
    7. Uslu K, Coleman AS, Allman WR, Katsenelson N, Bram RJ, Alugupalli KR, Akkoyunlu M. Impaired B Cell Receptor Signaling Is Responsible for Reduced TACI Expression and Function in X-Linked Immunodeficient Mice. J Immunol. 2014 Apr 15; 192(8):3582-95. PMID: 24646744.
      View in: PubMed
    8. Dickinson GS, Sun G, Bram RJ, Alugupalli KR. Efficient B Cell Responses to Borrelia hermsii Infection Depend on BAFF and BAFFR but Not TACI. Infect Immun. 2014 Jan; 82(1):453-9. PMID: 24218480.
      View in: PubMed
    9. Dickinson GS, Alugupalli KR. Deciphering the role of Toll-like receptors in humoral responses to Borreliae. Front Biosci (Schol Ed). 2012; 4:699-712. PMID: 22202086.
      View in: PubMed
    10. Vuyyuru R, Liu H, Manser T, Alugupalli KR. Characteristics of Borrelia hermsii infection in human hematopoietic stem cell-engrafted mice mirror those of human relapsing fever. Proc Natl Acad Sci U S A. 2011 Dec 20; 108(51):20707-12. PMID: 22143787.
      View in: PubMed
    11. Colombo MJ, Abraham D, Shibuya A, Alugupalli KR. B1b lymphocyte-derived antibodies control Borrelia hermsii independent of Fca/µ receptor and in the absence of host cell contact. Immunol Res. 2011 Dec; 51(2-3):249-56. PMID: 22139824.
      View in: PubMed
    12. Dickinson GS, Piccone H, Sun G, Lien E, Gatto L, Alugupalli KR. Toll-like receptor 2 deficiency results in impaired antibody responses and septic shock during Borrelia hermsii infection. Infect Immun. 2010 Nov; 78(11):4579-88. PMID: 20696824.
      View in: PubMed
    13. Colombo MJ, Sun G, Alugupalli KR. T-cell-independent immune responses do not require CXC ligand 13-mediated B1 cell migration. Infect Immun. 2010 Sep; 78(9):3950-6. PMID: 20584971.
      View in: PubMed
    14. Shriner AK, Liu H, Sun G, Guimond M, Alugupalli KR. IL-7-dependent B lymphocytes are essential for the anti-polysaccharide response and protective immunity to Streptococcus pneumoniae. J Immunol. 2010 Jul 1; 185(1):525-31. PMID: 20505146.
      View in: PubMed
    15. Liu H, Fitzgerald D, Gran B, Leong JM, Alugupalli KR. Induction of distinct neurologic disease manifestations during relapsing fever requires T lymphocytes. J Immunol. 2010 May 15; 184(10):5859-64. PMID: 20382883.
      View in: PubMed
    16. Benoit VM, Petrich A, Alugupalli KR, Marty-Roix R, Moter A, Leong JM, Boyartchuk VL. Genetic control of the innate immune response to Borrelia hermsii influences the course of relapsing fever in inbred strains of mice. Infect Immun. 2010 Feb; 78(2):586-94. PMID: 19995898.
      View in: PubMed
    17. Faber M, Li J, Kean RB, Hooper DC, Alugupalli KR, Dietzschold B. Effective preexposure and postexposure prophylaxis of rabies with a highly attenuated recombinant rabies virus. Proc Natl Acad Sci U S A. 2009 Jul 7; 106(27):11300-5. PMID: 19581599.
      View in: PubMed
    18. Alugupalli KR, Abraham D. B cell multitasking is required to control nematode infection. Immunity. 2009 Mar 20; 30(3):317-9. PMID: 19303384.
      View in: PubMed
    19. Colombo MJ, Alugupalli KR. Complement factor H-binding protein, a putative virulence determinant of Borrelia hermsii, is an antigenic target for protective B1b lymphocytes. J Immunol. 2008 Apr 1; 180(7):4858-64. PMID: 18354209.
      View in: PubMed
    20. O'Brien K, Fitzgerald DC, Naiken K, Alugupalli KR, Rostami AM, Gran B. Role of the innate immune system in autoimmune inflammatory demyelination. Curr Med Chem. 2008; 15(11):1105-15. PMID: 18473806.
      View in: PubMed
    21. Alugupalli KR. A distinct role for B1b lymphocytes in T cell-independent immunity. Curr Top Microbiol Immunol. 2008; 319:105-30. PMID: 18080416.
      View in: PubMed
    22. Wong SM, Alugupalli KR, Ram S, Akerley BJ. The ArcA regulon and oxidative stress resistance in Haemophilus influenzae. Mol Microbiol. 2007 Jun; 64(5):1375-90. PMID: 17542927.
      View in: PubMed
    23. Alugupalli KR, Akira S, Lien E, Leong JM. MyD88- and Bruton's tyrosine kinase-mediated signals are essential for T cell-independent pathogen-specific IgM responses. J Immunol. 2007 Mar 15; 178(6):3740-9. PMID: 17339472.
      View in: PubMed
    24. Alugupalli KR, Gerstein RM. Divide and conquer: division of labor by B-1 B cells. Immunity. 2005 Jul; 23(1):1-2. PMID: 16039572.
      View in: PubMed
    25. Alugupalli KR, Leong JM, Woodland RT, Muramatsu M, Honjo T, Gerstein RM. B1b lymphocytes confer T cell-independent long-lasting immunity. Immunity. 2004 Sep; 21(3):379-90. PMID: 15357949.
      View in: PubMed
    26. Alugupalli KR, Michelson AD, Joris I, Schwan TG, Hodivala-Dilke K, Hynes RO, Leong JM. Spirochete-platelet attachment and thrombocytopenia in murine relapsing fever borreliosis. Blood. 2003 Oct 15; 102(8):2843-50. PMID: 12855586.
      View in: PubMed
    27. Alugupalli KR, Gerstein RM, Chen J, Szomolanyi-Tsuda E, Woodland RT, Leong JM. The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes. J Immunol. 2003 Apr 1; 170(7):3819-27. PMID: 12646649.
      View in: PubMed
    28. Alugupalli KR, Michelson AD, Barnard MR, Leong JM. Serial determinations of platelet counts in mice by flow cytometry. Thromb Haemost. 2001 Aug; 86(2):668-71. PMID: 11522020.
      View in: PubMed
    29. Alugupalli KR, Michelson AD, Barnard MR, Robbins D, Coburn J, Baker EK, Ginsberg MH, Schwan TG, Leong JM. Platelet activation by a relapsing fever spirochaete results in enhanced bacterium-platelet interaction via integrin alphaIIbbeta3 activation. Mol Microbiol. 2001 Jan; 39(2):330-40. PMID: 11136454.
      View in: PubMed
    30. Magoun L, Zückert WR, Robbins D, Parveen N, Alugupalli KR, Schwan TG, Barbour AG, Leong JM. Variable small protein (Vsp)-dependent and Vsp-independent pathways for glycosaminoglycan recognition by relapsing fever spirochaetes. Mol Microbiol. 2000 May; 36(4):886-97. PMID: 10844676.
      View in: PubMed
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