Lorraine Iacovitti

TitleProfessor
InstitutionThomas Jefferson University
DepartmentDepartment of Neurosciences
Address900 Walnut Street
Philadelphia PA 19107
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    INTRAMURAL COMMITTEES AND ACTIVITIES (1997-present)
    1995-1998 University Grievance Committee
    1997-1998 University Steering Committee for the Faculty (elected)
    1998-2000 Chairman, Research Committee, Department of Neurology
    1998-2000 University Research Council
    2000-2001 Co-chairman, University Research Committee
    2001-2005 Chairman, University Research Committee

    EXTRAMURAL COMMITTEES AND ACTIVITIES (1997-present)
    NSF Grant Reviewer - 1983-present
    NIH Study Section Subcommittee NLS 1 - 1991, 1992, 1993, 1997
    NIH NRSA Study Section- 1997
    NIH Special Review Panel- Parkinson's Disease Center Grants- 1998
    Philadelphia Chapter of the Society for Neuroscience 1996-1998
    Drexel University Honors Program in Science, Consultant 1997-1999
    Board of Trustees, Educational Committee, Germantown Academy 1997-1999
    Advisor, The Lee Foundation 1998

    OTHER PROFESSIONAL ACTIVITIES (1997-present)
    1983-present NSF Grant Reviewer
    1991, 1992, 1993, 1997 NIH Study Section Subcommittee NLS 1
    1998,1999, 2000 NIH Special Review Panel- Parkinson's Disease Center of Excellence Grants

    EDITORIAL ACTIVITIES
    Journal of Neuroscience, Neuroscience, Journal of Neurochemistry, Developmental Biology, Neuroscience Letters, Journal of Neurobiology, Anatomy and Embryology, Journal of Neurocytology, Neuroendocrinology, Biotechniques


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Iacovitti L. On the road from phenotypic plasticity to stem cell therapy. J Neurosci. 2021 May 05. PMID: 33958488.
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    2. Cai J, Kropf E, Hou YM, Iacovitti L. A stress-free strategy to correct point mutations in patient iPS cells. Stem Cell Res. 2021 Apr 08; 53:102332. PMID: 33857832.
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    3. Heinsinger NM, Spagnuolo G, Allahyari RV, Galer S, Fox T, Jaffe DA, Thomas SJ, Iacovitti L, Lepore AC. Facial grimace testing as an assay of neuropathic pain-related behavior in a mouse model of cervical spinal cord injury. Exp Neurol. 2020 Dec; 334:113468. PMID: 32966805.
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    4. Fu CH, Iascone DM, Petrof I, Hazra A, Zhang X, Pyfer MS, Tosi U, Corbett BF, Cai J, Lee J, Park J, Iacovitti L, Scharfman HE, Enikolopov G, Chin J. Early Seizure Activity Accelerates Depletion of Hippocampal Neural Stem Cells and Impairs Spatial Discrimination in an Alzheimer's Disease Model. Cell Rep. 2019 Jun 25; 27(13):3741-3751.e4. PMID: 31242408.
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    5. Kostuk EW, Cai J, Iacovitti L. Subregional differences in astrocytes underlie selective neurodegeneration or protection in Parkinson's disease models in culture. Glia. 2019 Apr 26. PMID: 31025779.
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    6. Schmidt RF, Theofanis TN, Lang MJ, Stricsek GP, Lin R, Lebrun A, Hooper DC, Rosenwasser RH, Sharan AD, Iacovitti L. Sphenopalatine Ganglion Stimulation is a Reversible and Frequency-Dependent Modulator of the Blood-Brain Barrier. Brain Res. 2019 Apr 26. PMID: 31034813.
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    7. Lin R, Cai J, Kenyon L, Iozzo R, Rosenwasser R, Iacovitti L. Systemic Factors Trigger Vasculature Cells to Drive Notch Signaling and Neurogenesis in Neural Stem Cells in the Adult Brain. Stem Cells. 2018 Nov 15. PMID: 30431198.
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    8. Kostuk EW, Cai J, Iacovitti L. Regional microglia are transcriptionally distinct but similarly exacerbate neurodegeneration in a culture model of Parkinson's disease. J Neuroinflammation. 2018 May 11; 15(1):139. PMID: 29751760.
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    9. Lin R, Lang M, Heinsinger N, Stricsek G, Zhang J, Iozzo R, Rosenwasser R, Iacovitti L. Stepwise impairment of neural stem cell proliferation and neurogenesis concomitant with disruption of blood-brain barrier in recurrent ischemic stroke. Neurobiol Dis. 2018 Mar 29; 115:49-58. PMID: 29605425.
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    10. Falnikar A, Stratton J, Lin R, Andrews CE, Tyburski A, Trovillion VA, Gottschalk C, Ghosh B, Iacovitti L, Elliott MB, Lepore AC. Differential response in novel stem cell niches of the brain following cervical spinal cord injury and traumatic brain injury. J Neurotrauma. 2018 Feb 22. PMID: 29471717.
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    11. Xiong Y, Neifert S, Karuppagounder SS, Liu Q, Stankowski JN, Lee BD, Ko HS, Lee Y, Grima JC, Mao X, Jiang H, Kang SU, Swing DA, Iacovitti L, Tessarollo L, Dawson TM, Dawson VL. Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice. Proc Natl Acad Sci U S A. 2018 Feb 13; 115(7):1635-1640. PMID: 29386392.
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    12. Petruk S, Mariani SA, De Dominici M, Porazzi P, Minieri V, Cai J, Iacovitti L, Flomenberg N, Calabretta B, Mazo A. Structure of Nascent Chromatin Is Essential for Hematopoietic Lineage Specification. Cell Rep. 2017 Apr 11; 19(2):295-306. PMID: 28402853.
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    13. Petruk S, Cai J, Sussman R, Sun G, Kovermann SK, Mariani SA, Calabretta B, McMahon SB, Brock HW, Iacovitti L, Mazo A. Delayed Accumulation of H3K27me3 on Nascent DNA Is Essential for Recruitment of Transcription Factors at Early Stages of Stem Cell Differentiation. Mol Cell. 2017 Apr 20; 66(2):247-257.e5. PMID: 28410996.
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    14. Horowitz A, Yang J, Cai J, Iacovitti L. The versatility of RhoA activities in neural differentiation. Small GTPases. 2017 Jan 26; 1-7. PMID: 28125332.
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    15. Lin R, Cai J, Kostuk EW, Rosenwasser R, Iacovitti L. Fumarate modulates the immune/inflammatory response and rescues nerve cells and neurological function after stroke in rats. J Neuroinflammation. 2016 Oct 13; 13(1):269. PMID: 27733178.
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    16. Westergard T, Jensen BK, Wen X, Cai J, Kropf E, Iacovitti L, Pasinelli P, Trotti D. Cell-to-Cell Transmission of Dipeptide Repeat Proteins Linked to C9orf72-ALS/FTD. Cell Rep. 2016 Oct 11; 17(3):645-652. PMID: 27732842.
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    17. Monti DA, Zabrecky G, Kremens D, Liang TW, Wintering NA, Cai J, Wei X, Bazzan AJ, Zhong L, Bowen B, Intenzo CM, Iacovitti L, Newberg AB. N-Acetyl Cysteine May Support Dopamine Neurons in Parkinson's Disease: Preliminary Clinical and Cell Line Data. PLoS One. 2016; 11(6):e0157602. PMID: 27309537.
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    18. Iacovitti L. Neuroprotection: Basic mechanisms and translational potential. Brain Res. 2015 Dec 2; 1628(Pt B):245-6. PMID: 26671723.
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    19. Gu H, Lazarenko RM, Koktysh D, Iacovitti L, Zhang Q. A Stem Cell-Derived Platform for Studying Single Synaptic Vesicles in Dopaminergic Synapses. Stem Cells Transl Med. 2015 Aug; 4(8):887-93. PMID: 26025981.
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    20. Lin R, Iacovitti L. Classic and novel stem cell niches in brain homeostasis and repair. Brain Res. 2015 Dec 2; 1628(Pt B):327-42. PMID: 25931262.
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    21. Lin R, Cai J, Nathan C, Wei X, Schleidt S, Rosenwasser R, Iacovitti L. Neurogenesis is enhanced by stroke in multiple new stem cell niches along the ventricular system at sites of high BBB permeability. Neurobiol Dis. 2015 Feb; 74:229-39. PMID: 25484283.
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    22. Iacovitti L, Wei X, Cai J, Kostuk EW, Lin R, Gorodinsky A, Roman P, Kusek G, Das SS, Dufour A, Martinez TN, Dave KD. The hTH-GFP Reporter Rat Model for the Study of Parkinson's Disease. PLoS One. 2014; 9(12):e113151. PMID: 25462571.
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    23. Sun Y, Williams A, Waisbourd M, Iacovitti L, Katz LJ. Stem cell therapy for glaucoma: science or snake oil? Surv Ophthalmol. 2015 Mar-Apr; 60(2):93-105. PMID: 25132498.
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    24. Sheela Rani CS, Soto-Pina A, Iacovitti L, Strong R. Evolutionary conservation of an atypical glucocorticoid-responsive element in the human tyrosine hydroxylase gene. J Neurochem. 2013 Jul; 126(1):19-28. PMID: 23647419.
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    25. Goldmacher GV, Nasser R, Lee DY, Yigit S, Rosenwasser R, Iacovitti L. Tracking Transplanted Bone Marrow Stem Cells and Their Effects in the Rat MCAO Stroke Model. PLoS One. 2013; 8(3):e60049. PMID: 23555879.
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    26. Cai J, Schleidt S, Pelta-Heller J, Hutchings D, Cannarsa G, Iacovitti L. BMP and TGF-ß pathway mediators are critical upstream regulators of Wnt signaling during midbrain dopamine differentiation in human pluripotent stem cells. Dev Biol. 2013 Apr 1; 376(1):62-73. PMID: 23352789.
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    27. Phani S, Jablonski M, Pelta-Heller J, Cai J, Iacovitti L. Gremlin is a novel VTA derived neuroprotective factor for dopamine neurons. Brain Res. 2013 Mar 15; 1500:88-98. PMID: 23348379.
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    28. Cai J, Yang M, Poremsky E, Kidd S, Schneider JS, Iacovitti L. Dopaminergic neurons derived from human induced pluripotent stem cells survive and integrate into 6-OHDA-lesioned rats. Stem Cells Dev. 2010 Jul; 19(7):1017-23. PMID: 19824823.
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    29. Page ME, Bao L, Andre P, Pelta-Heller J, Sluzas E, Gonzalez-Alegre P, Bogush A, Khan LE, Iacovitti L, Rice ME, Ehrlich ME. Cell-autonomous alteration of dopaminergic transmission by wild type and mutant (DeltaE) TorsinA in transgenic mice. Neurobiol Dis. 2010 Sep; 39(3):318-26. PMID: 20460154.
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    30. Phani S, Gonye G, Iacovitti L. VTA neurons show a potentially protective transcriptional response to MPTP. Brain Res. 2010 Jul 9; 1343:1-13. PMID: 20462502.
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    31. Yang M, Wei X, Li J, Heine LA, Rosenwasser R, Iacovitti L. Changes in host blood factors and brain glia accompanying the functional recovery after systemic administration of bone marrow stem cells in ischemic stroke rats. Cell Transplant. 2010; 19(9):1073-84. PMID: 20412636.
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    32. Bennett LB, Cai J, Enikolopov G, Iacovitti L. Heterotopically transplanted CVO neural stem cells generate neurons and migrate with SVZ cells in the adult mouse brain. Neurosci Lett. 2010 May 7; 475(1):1-6. PMID: 20298755.
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    33. Jasmin JF, Yang M, Iacovitti L, Lisanti MP. Genetic ablation of caveolin-1 increases neural stem cell proliferation in the subventricular zone (SVZ) of the adult mouse brain. Cell Cycle. 2009 Dec; 8(23):3978-83. PMID: 19923909.
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    34. Daniel JA, Galbraith S, Iacovitti L, Abdipranoto A, Vissel B. Functional heterogeneity at dopamine release sites. J Neurosci. 2009 Nov 18; 29(46):14670-80. PMID: 19923300.
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    35. Donaldson AE, Cai J, Yang M, Iacovitti L. Human amniotic fluid stem cells do not differentiate into dopamine neurons in vitro or after transplantation in vivo. Stem Cells Dev. 2009 Sep; 18(7):1003-12. PMID: 19049321.
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    36. Bennett L, Yang M, Enikolopov G, Iacovitti L. Circumventricular organs: a novel site of neural stem cells in the adult brain. Mol Cell Neurosci. 2009 Jul; 41(3):337-47. PMID: 19409493.
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    37. Cai J, Donaldson A, Yang M, German MS, Enikolopov G, Iacovitti L. The role of Lmx1a in the differentiation of human embryonic stem cells into midbrain dopamine neurons in culture and after transplantation into a Parkinson's disease model. Stem Cells. 2009 Jan; 27(1):220-9. PMID: 18832589.
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    38. Han BS, Iacovitti L, Katano T, Hattori N, Seol W, Kim KS. Expression of the LRRK2 gene in the midbrain dopaminergic neurons of the substantia nigra. Neurosci Lett. 2008 Sep 19; 442(3):190-4. PMID: 18634852.
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    39. Romano G, Macaluso M, Lucchetti C, Iacovitti L. Transcription and epigenetic profile of the promoter, first exon and first intron of the human tyrosine hydroxylase gene. J Cell Physiol. 2007 May; 211(2):431-8. PMID: 17195153.
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    40. Iacovitti L, Donaldson AE, Marshall CE, Suon S, Yang M. A protocol for the differentiation of human embryonic stem cells into dopaminergic neurons using only chemically defined human additives: Studies in vitro and in vivo. Brain Res. 2007 Jan 5; 1127(1):19-25. PMID: 17123482.
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    41. Suon S, Yang M, Iacovitti L. Adult human bone marrow stromal spheres express neuronal traits in vitro and in a rat model of Parkinson's disease. Brain Res. 2006 Aug 23; 1106(1):46-51. PMID: 16828720.
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    42. Jin H, Romano G, Marshall C, Donaldson AE, Suon S, Iacovitti L. Tyrosine hydroxylase gene regulation in human neuronal progenitor cells does not depend on Nurr1 as in the murine and rat systems. J Cell Physiol. 2006 Apr; 207(1):49-57. PMID: 16252282.
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    43. Donaldson AE, Marshall CE, Yang M, Suon S, Iacovitti L. Purified mouse dopamine neurons thrive and function after transplantation into brain but require novel glial factors for survival in culture. Mol Cell Neurosci. 2005 Dec; 30(4):601-10. PMID: 16456927.
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    44. Donaldson AE, Marshall CE, Yang M, Suon S, Iacovitti L. Purified mouse dopamine neurons thrive and function after transplantation into brain but require novel glial factors for survival in culture. Mol Cell Neurosci. 2005 Sep; 30(1):108-17. PMID: 16024255.
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    45. Romano G, Suon S, Jin H, Donaldson AE, Iacovitti L. Characterization of five evolutionary conserved regions of the human tyrosine hydroxylase (TH) promoter: implications for the engineering of a human TH minimal promoter assembled in a self-inactivating lentiviral vector system. J Cell Physiol. 2005 Aug; 204(2):666-77. PMID: 15744773.
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    46. Suon S, Jin H, Donaldson AE, Caterson EJ, Tuan RS, Deschennes G, Marshall C, Iacovitti L. Transient differentiation of adult human bone marrow cells into neuron-like cells in culture: development of morphological and biochemical traits is mediated by different molecular mechanisms. Stem Cells Dev. 2004 Dec; 13(6):625-35. PMID: 15684830.
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    47. Yang M, Donaldson AE, Marshall CE, Shen J, Iacovitti L. Studies on the differentiation of dopaminergic traits in human neural progenitor cells in vitro and in vivo. Cell Transplant. 2004; 13(5):535-47. PMID: 15565866.
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    48. Yang M, Donaldson AE, Jiang Y, Iacovitti L. Factors influencing the differentiation of dopaminergic traits in transplanted neural stem cells. Cell Mol Neurobiol. 2003 Oct; 23(4-5):851-64. PMID: 14514036.
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    49. Kessler MA, Yang M, Gollomp KL, Jin H, Iacovitti L. The human tyrosine hydroxylase gene promoter. Brain Res Mol Brain Res. 2003 Apr 10; 112(1-2):8-23. PMID: 12670698.
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    50. Yang M, Stull ND, Berk MA, Snyder EY, Iacovitti L. Neural stem cells spontaneously express dopaminergic traits after transplantation into the intact or 6-hydroxydopamine-lesioned rat. Exp Neurol. 2002 Sep; 177(1):50-60. PMID: 12429210.
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    51. Stull ND, Polan DP, Iacovitti L. Antioxidant compounds protect dopamine neurons from death due to oxidative stress in vitro. Brain Res. 2002 Mar 29; 931(2):181-5. PMID: 11897104.
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