Thomas Jefferson University

Louise Fong

TitleAssoc Prof CHP
InstitutionThomas Jefferson University
DepartmentNursing - Undergraduate
Address1020 Locust St.
Philadelphia PA 19107
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    R01CA118560     (FONG, LOUISE Y.Y.)Dec 1, 2005 - Mar 31, 2019
    NIH
    Chemoprevention of upper aerodigestive tract cancer by dietary zinc
    Role: Principal Investigator
    R21CA127085     (FONG, LOUISE Y.Y.)Jan 25, 2008 - Dec 31, 2010
    NIH
    Modulation of DNA methylation status by dietary zinc: role in cancer prevention
    Role: Principal Investigator
    R21CA152505     (FONG, LOUISE Y.Y.)Mar 1, 2011 - Feb 28, 2014
    NIH
    Modulation of miR-31 by dietary zinc deficiency in rat esophageal carcinogenesis
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Fong LY, Huebner K, Jing R, Smalley KJ, Brydges CR, Fiehn O, Farber JL, Croce CM. Zinc treatment reverses and anti-Zn-regulated miRs suppress esophageal carcinomas in?vivo. Proc Natl Acad Sci U S A. 2023 05 16; 120(20):e2220334120. PMID: 37155893.
      Citations:    
    2. Fong LY, Taccioli C, Palamarchuk A, Tagliazucchi GM, Jing R, Smalley KJ, Fan S, Altemus J, Fiehn O, Huebner K, Farber JL, Croce CM. Abrogation of esophageal carcinoma development in miR-31 knockout rats. Proc Natl Acad Sci U S A. 2020 Mar 17; 117(11):6075-6085. PMID: 32123074.
      Citations:    
    3. Fong LY, Jing R, Smalley KJ, Wang ZX, Taccioli C, Fan S, Chen H, Alder H, Huebner K, Farber JL, Fiehn O, Croce CM. Human-like hyperplastic prostate with low ZIP1 induced solely by Zn deficiency in rats. Proc Natl Acad Sci U S A. 2018; 115(47):E11091-E11100.
    4. Fong LY, Jing R, Smalley KJ, Wang ZX, Taccioli C, Fan S, Chen H, Alder H, Huebner K, Farber JL, Fiehn O, Croce CM. Human-like hyperplastic prostate with low ZIP1 induced solely by Zn deficiency in rats. Proc Natl Acad Sci U S A. 2018 11 20; 115(47):E11091-E11100. PMID: 30397150.
      Citations:    
    5. Fong LY, Jing R, Smalley KJ, Taccioli C, Fahrmann J, Barupal DK, Alder H, Farber JL, Fiehn O, Croce CM. Integration of metabolomics, transcriptomics, and microRNA expression profiling reveals a miR-143-HK2-glucose network underlying zinc-deficiency-associated esophageal neoplasia. Oncotarget. 2017 Oct 10; 8(47):81910-81925. PMID: 29137232.
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    6. Fong LY, Farber JL, Croce CM. Zinc intake, microRNA dysregulation, and esophageal cancer. Aging (Albany NY). 2016 Jun; 8(6):1161-2. PMID: 27280381.
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    7. Sun J, Shen R, Schrock MS, Liu J, Pan X, Quimby D, Zanesi N, Druck T, Fong LY, Huebner K. Reduction in squamous cell carcinomas in mouse skin by dietary zinc supplementation. Cancer Med. 2016 Aug; 5(8):2032-42. PMID: 27185213.
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    8. Fong LY, Taccioli C, Jing R, Smalley KJ, Alder H, Jiang Y, Fadda P, Farber JL, Croce CM. MicroRNA dysregulation and esophageal cancer development depend on the extent of zinc dietary deficiency. Oncotarget. 2016 Mar 8; 7(10):10723-38. PMID: 26918602.
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    9. Taccioli C, Garofalo M, Chen H, Jiang Y, Tagliazucchi GM, Di Leva G, Alder H, Fadda P, Middleton J, Smalley KJ, Selmi T, Naidu S, Farber JL, Croce CM, Fong LY. Repression of Esophageal Neoplasia and Inflammatory Signaling by Anti-miR-31 Delivery In Vivo. J Natl Cancer Inst. 2015 Nov; 107(11). PMID: 26286729.
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    10. Feith DJ, Pegg AE, Fong LY. Targeted expression of ornithine decarboxylase antizyme prevents upper aerodigestive tract carcinogenesis in p53-deficient mice. Carcinogenesis. 2013 Mar; 34(3):570-6. PMID: 23222816.
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    11. Alder H, Taccioli C, Chen H, Jiang Y, Smalley KJ, Fadda P, Ozer HG, Huebner K, Farber JL, Croce CM, Fong LY. Dysregulation of miR-31 and miR-21 induced by zinc deficiency promotes esophageal cancer. Carcinogenesis. 2012 Sep; 33(9):1736-44. PMID: 22689922.
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    12. Fong LY, Jiang Y, Rawahneh ML, Smalley KJ, Croce CM, Farber JL, Huebner K. Zinc supplementation suppresses 4-nitroquinoline 1-oxide-induced rat oral carcinogenesis. Carcinogenesis. 2011 Apr; 32(4):554-60. PMID: 21245412.
      Citations:    
    13. Sun J, Liu J, Pan X, Quimby D, Zanesi N, Druck T, Pfeifer GP, Croce CM, Fong LY, Huebner K. Effect of zinc supplementation on N-nitrosomethylbenzylamine-induced forestomach tumor development and progression in tumor suppressor-deficient mouse strains. Carcinogenesis. 2011 Mar; 32(3):351-8. PMID: 21097531.
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    14. Wan SG, Taccioli C, Jiang Y, Chen H, Smalley KJ, Huang K, Liu XP, Farber JL, Croce CM, Fong LY. Zinc deficiency activates S100A8 inflammation in the absence of COX-2 and promotes murine oral-esophageal tumor progression. Int J Cancer. 2011 Jul 15; 129(2):331-45. PMID: 20857495.
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    15. Sun J, Okumura H, Yearsley M, Frankel W, Fong LY, Druck T, Huebner K. Nit1 and Fhit tumor suppressor activities are additive. J Cell Biochem. 2009 Aug 15; 107(6):1097-106. PMID: 19479888.
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    16. Taccioli C, Wan SG, Liu CG, Alder H, Volinia S, Farber JL, Croce CM, Fong LY. Zinc replenishment reverses overexpression of the proinflammatory mediator S100A8 and esophageal preneoplasia in the rat. Gastroenterology. 2009 Mar; 136(3):953-66. PMID: 19111725.
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    17. Taccioli C, Fabbri E, Visone R, Volinia S, Calin GA, Fong LY, Gambari R, Bottoni A, Acunzo M, Hagan J, Iorio MV, Piovan C, Romano G, Croce CM. UCbase & miRfunc: a database of ultraconserved sequences and microRNA function. Nucleic Acids Res. 2009 Jan; 37(Database issue):D41-8. PMID: 18945703.
      Citations:    
    18. Fong LY, Jiang Y, Riley M, Liu X, Smalley KJ, Guttridge DC, Farber JL. Prevention of upper aerodigestive tract cancer in zinc-deficient rodents: inefficacy of genetic or pharmacological disruption of COX-2. Int J Cancer. 2008 Mar 1; 122(5):978-89. PMID: 17985342.
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    19. Aqeilan RI, Hagan JP, Aqeilan HA, Pichiorri F, Fong LY, Croce CM. Inactivation of the Wwox gene accelerates forestomach tumor progression in vivo. Cancer Res. 2007 Jun 15; 67(12):5606-10. PMID: 17575124.
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    20. Vecchione A, Baldassarre G, Ishii H, Nicoloso MS, Belletti B, Petrocca F, Zanesi N, Fong LY, Battista S, Guarnieri D, Baffa R, Alder H, Farber JL, Donovan PJ, Croce CM. Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development. Cancer Cell. 2007 Mar; 11(3):275-89. PMID: 17349584.
      Citations:    
    21. Fong LY, Jiang Y, Farber JL. Zinc deficiency potentiates induction and progression of lingual and esophageal tumors in p53-deficient mice. Carcinogenesis. 2006 Jul; 27(7):1489-96. PMID: 16543248.
      Citations:    
    22. Liu CG, Zhang L, Jiang Y, Chatterjee D, Croce CM, Huebner K, Fong LY. Modulation of gene expression in precancerous rat esophagus by dietary zinc deficit and replenishment. Cancer Res. 2005 Sep 1; 65(17):7790-9. PMID: 16140947.
      Citations:    
    23. Drusco A, Zanesi N, Roldo C, Trapasso F, Farber JL, Fong LY, Croce CM. Knockout mice reveal a tumor suppressor function for Testin. Proc Natl Acad Sci U S A. 2005 Aug 2; 102(31):10947-51. PMID: 16033868.
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    24. Guler G, Iliopoulos D, Han SY, Fong LY, Lubet RA, Grubbs CJ, Huebner K. Hypermethylation patterns in the Fhit regulatory region are tissue specific. Mol Carcinog. 2005 Jul; 43(3):175-81. PMID: 15937960.
      Citations:    
    25. Fong LY, Zhang L, Jiang Y, Farber JL. Dietary zinc modulation of COX-2 expression and lingual and esophageal carcinogenesis in rats. J Natl Cancer Inst. 2005 Jan 5; 97(1):40-50. PMID: 15632379.
      Citations:    
    26. Lubet RA, Huebner K, Fong LY, Altieri DC, Steele VE, Kopelovich L, Kavanaugh C, Juliana MM, Soong SJ, Grubbs CJ. 4-Hydroxybutyl(butyl)nitrosamine-induced urinary bladder cancers in mice: characterization of FHIT and survivin expression and chemopreventive effects of indomethacin. Carcinogenesis. 2005 Mar; 26(3):571-8. PMID: 15591090.
      Citations:    
    27. Vecchione A, Sevignani C, Giarnieri E, Zanesi N, Ishii H, Cesari R, Fong LY, Gomella LG, Croce CM, Baffa R. Inactivation of the FHIT gene favors bladder cancer development. Clin Cancer Res. 2004 Nov 15; 10(22):7607-12. PMID: 15569992.
      Citations:    
    28. Ishii H, Vecchione A, Furukawa Y, Croce CM, Huebner K, Fong LY. Differentially expressed genes execute zinc-induced apoptosis in precancerous esophageal epithelium of zinc-deficient rats. Oncogene. 2004 Oct 21; 23(49):8040-8. PMID: 15361827.
      Citations:    
    29. Han SY, Iliopoulos D, Druck T, Guler G, Grubbs CJ, Pereira M, Zhang Z, You M, Lubet RA, Fong LY, Huebner K. CpG methylation in the Fhit regulatory region: relation to Fhit expression in murine tumors. Oncogene. 2004 May 13; 23(22):3990-8. PMID: 15007387.
      Citations:    
    30. Ishii H, Vecchione A, Fong LY, Zanesi N, Trapasso F, Furukawa Y, Baffa R, Huebner K, Croce CM. Cancer prevention and therapy in a preclinical mouse model: impact of FHIT viruses. Curr Gene Ther. 2004 Mar; 4(1):53-63. PMID: 15032614.
      Citations:    
    31. Fong LY, Feith DJ, Pegg AE. Antizyme overexpression in transgenic mice reduces cell proliferation, increases apoptosis, and reduces N-nitrosomethylbenzylamine-induced forestomach carcinogenesis. Cancer Res. 2003 Jul 15; 63(14):3945-54. PMID: 12873989.
      Citations:    
    32. Fong LY, Mancini R, Nakagawa H, Rustgi AK, Huebner K. Combined cyclin D1 overexpression and zinc deficiency disrupts cell cycle and accelerates mouse forestomach carcinogenesis. Cancer Res. 2003 Jul 15; 63(14):4244-52. PMID: 12874033.
      Citations:    
    33. Ishii H, Zanesi N, Vecchione A, Trapasso F, Yendamuri S, Sarti M, Baffa R, During MJ, Huebner K, Fong LY, Croce CM. Regression of upper gastric cancer in mice by FHIT gene delivery. FASEB J. 2003 Sep; 17(12):1768-70. PMID: 12958204.
      Citations:    
    34. Fong LY, Ishii H, Nguyen VT, Vecchione A, Farber JL, Croce CM, Huebner K. p53 deficiency accelerates induction and progression of esophageal and forestomach tumors in zinc-deficient mice. Cancer Res. 2003 Jan 1; 63(1):186-95. PMID: 12517797.
      Citations:    
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