Thomas Jefferson University

Michael Holinstat

TitleAssoc Prof CHP
InstitutionThomas Jefferson University
DepartmentNursing - Undergraduate
Address1015 Walnut St.
Philadelphia PA 19107
vCardDownload vCard

    Collapse Research 
    Collapse research activities and funding
    F32HL082068     (HOLINSTAT, MICHAEL ALLAN)Aug 1, 2005 - Jul 31, 2007
    NIH
    PAR mediated Rap 1 activation in platelets
    Role: Principal Investigator
    R00HL089457     (HOLINSTAT, MICHAEL ALLAN)Aug 1, 2007 - Apr 30, 2012
    NIH
    Thrombin regulation of Rap1 signaling in human platelet activity
    Role: Principal Investigator
    K99HL089457     (HOLINSTAT, MICHAEL ALLAN)Aug 1, 2007 - Jul 31, 2012
    NIH
    Thrombin regulation of Rap1 signaling in human platelet activity
    Role: Principal Investigator
    R01MD007880     (BRAY, PAUL F.)Jul 9, 2013 - Feb 28, 2019
    NIH
    Genetic regulation of racial differences in platelet reactivity
    Role: Co-Principal Investigator
    R01HL114405     (HOLINSTAT, MICHAEL ALLAN)Aug 1, 2013 - May 31, 2018
    NIH
    Role of 12-lipoxygenase in platelet reactivity and type 2 diabetes mellitus
    Role: Principal Investigator
    R01GM105671     (HOLINSTAT, MICHAEL ALLAN)Aug 1, 2013 - Jul 31, 2019
    NIH
    12-HETrE regulation of platelets
    Role: Principal Investigator
    TL1TR002242     (HOLINSTAT, MICHAEL ALLAN)Jun 1, 2017 - Feb 28, 2022
    NIH
    NRSA Training Core
    Role: Principal Investigator
    R35GM131835     (HOLINSTAT, MICHAEL ALLAN)Apr 1, 2019 - Mar 31, 2025
    NIH
    12-HETrE regulation of blood coagulation, hemostasis, and thrombosis
    Role: Principal Investigator
    R21TR003185     (HOLINSTAT, MICHAEL ALLAN)Jun 11, 2021 - May 31, 2024
    NIH
    Biomarkers for 12-lipoxygenase inhibition as a therapeutic intervention for heparin-induced thrombocytopenia and thrombosis (HIT/T)
    Role: Principal Investigator
    T32TR004371     (HOLINSTAT, MICHAEL ALLAN)Apr 1, 2023 - Mar 31, 2028
    NIH
    CTSA Predoctoral T32 at the University of Michigan
    Role: Principal Investigator
    R01HL181954     (ABDEL LATIF, AHMED)Aug 1, 2026 - Apr 30, 2030
    NIH
    Macrophage 12-Lipoxygenase Signaling as a Therapeutic Target in Heart Failure with Preserved Ejection Fraction
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kulkarni PP, Alluri RK, Godwin M, Forbes GL, Merkulova A, Lambert S, Vijay A, Palihati M, Kundu S, Shim YJ, Kalonji K, Schmaier AH, Holinstat M, Cameron SJ, McCrae KR. Protection of ?2GPI-deficient mice from thrombosis reflects a defect in PAR3-facilitated platelet activation. Blood. 2025 May 01; 145(18):2086-2099. PMID: 39869832.
      Citations:    
    2. Rodriguez A, Yu M, Phoo MT, Holinstat M, Schwendeman A. Antiplatelet Effects of DMPC-Based Synthetic High-Density Lipoproteins: Exploring Particle Structure and Noncholesterol Efflux Mechanisms. Mol Pharm. 2025 03 03; 22(3):1305-1317. PMID: 39888835.
      Citations:    
    3. Goerger K, Abbott K, Larson MK, Holinstat M. Cardiovascular Disease Risk Factors in the Native American Population. J Cardiovasc Dev Dis. 2025 Jan 16; 12(1). PMID: 39852305.
      Citations:    
    4. Goerger K, Caldwell M, Biermann G, Besh F, Flickema T, Patel P, Abbott K, Holinstat M, Larson MK. Observational Analyses of Ex Vivo Native American Platelet Responses. Int J Mol Sci. 2024 Nov 08; 25(22). PMID: 39596060.
      Citations:    
    5. Belenkovich M, Veksler R, Kreinin Y, Mekler T, Flores M, Sznitman J, Holinstat M, Korin N. Clot Accumulation in 3D Microfluidic Bifurcating Microvasculature Network. Micromachines (Basel). 2024 Jul 31; 15(8). PMID: 39203639.
      Citations:    
    6. Poscablo DM, Worthington AK, Smith-Berdan S, Rommel MGE, Manso BA, Adili R, Mok L, Reggiardo RE, Cool T, Mogharrab R, Myers J, Dahmen S, Medina P, Beaudin AE, Boyer SW, Holinstat M, Jonsson VD, Forsberg EC. An age-progressive platelet differentiation path from hematopoietic stem cells causes exacerbated thrombosis. Cell. 2024 Jun 06; 187(12):3090-3107.e21. PMID: 38749423.
      Citations:    
    7. Griffin MS, Dahlgren AR, Nagaswami C, Litvinov RI, Keeler K, Madenjian C, Fuentes R, Fish RJ, Neerman-Arbez M, Holinstat M, Adili R, Weisel JW, Shavit JA. Composition of thrombi in zebrafish: similarities and distinctions with mammals. J Thromb Haemost. 2024 04; 22(4):1056-1068. PMID: 38160724.
      Citations:    
    8. Stanger L, Yamaguchi A, Holinstat M. Antiplatelet strategies: past, present, and future. J Thromb Haemost. 2023 12; 21(12):3317-3328. PMID: 38000851.
      Citations:    
    9. Stanger L, Yamaguchi A, Yalavarthi P, Lambert S, Gilmore D, Rickenberg A, Luke C, Kumar K, Obi AT, White A, Bergh N, Dahl?f B, Holinstat M. The oxylipin analog CS585 prevents platelet activation and thrombosis through activation of the prostacyclin receptor. Blood. 2023 11 02; 142(18):1556-1569. PMID: 37624927.
      Citations:    
    10. Rickenberg A, Holinstat M. DAPT and GPVI: an antiplatelet triple threat. J Thromb Haemost. 2023 11; 21(11):3082-3084. PMID: 37858525.
      Citations:    
    11. Mobbs JI, Black KA, Tran M, Burger WAC, Venugopal H, Holman TR, Holinstat M, Thal DM, Glukhova A. Cryo-EM structures of human arachidonate 12S-lipoxygenase bound to endogenous and exogenous inhibitors. Blood. 2023 10 05; 142(14):1233-1242. PMID: 37506345.
      Citations:    
    12. Tran M, Stanger L, Narendra S, Holinstat M, Holman TR. Investigating the catalytic efficiency of C22-Fatty acids with LOX human isozymes and the platelet response of the C22-oxylipin products. Arch Biochem Biophys. 2023 10 01; 747:109742. PMID: 37696384.
      Citations:    
    13. Larsen HJ, Byrne D, ?zpolat T, Chauhan A, Bailey SL, Rhoads N, Reed F, Stolla MC, Adili R, Holinstat M, Fu X, Stolla M. Loss of 12-Lipoxygenase Improves the Post-Transfusion Function of Stored Platelets. Arterioscler Thromb Vasc Biol. 2023 10; 43(10):1990-2007. PMID: 37650322.
      Citations:    
    14. Kulkarni PP, Alluri RK, Godwin M, Forbes GL, Merkulova A, Vijay A, Palihati M, Kundu S, Jun-Shim Y, Schmaier A, Holinstat M, Cameron SJ, McCrae KR. Protection of ?2GPI Deficient Mice from Thrombosis Reflects a Defect in PAR3-facilitated Platelet Activation. bioRxiv. 2023 Aug 24. PMID: 37662286.
      Citations:    
    15. Tran M, Yang K, Glukhova A, Holinstat M, Holman T. Inhibitory Investigations of Acyl-CoA Derivatives against Human Lipoxygenase Isozymes. Int J Mol Sci. 2023 Jun 30; 24(13). PMID: 37446119.
      Citations:    
    16. Renna SA, Zhao X, Kunapuli SP, Ma P, Holinstat M, Boxer MB, Maloney DJ, Michael JV, McKenzie SE. Novel Strategy to Combat the Procoagulant Phenotype in Heparin-Induced Thrombocytopenia Using 12-LOX Inhibition. Arterioscler Thromb Vasc Biol. 2023 10; 43(10):1808-1817. PMID: 37345522.
      Citations:    
    17. Harris B, Singh DK, Verma M, Fahl SP, Rhodes M, Sprinkle SR, Wang M, Zhang Y, Perrigoue J, Kessel R, Peri S, West J, Giricz O, Boultwood J, Pellagatti A, Ramesh KH, Montagna C, Pradhan K, Tyner JW, Kennedy BK, Holinstat M, Steidl U, Sykes S, Verma A, Wiest DL. Ribosomal protein control of hematopoietic stem cell transformation through direct, non-canonical regulation of metabolism. bioRxiv. 2023 Jun 01. PMID: 37398007.
      Citations:    
    18. Banka AL, Guevara MV, Brannon ER, Nguyen NQ, Song S, Cady G, Pinsky DJ, Uhrich KE, Adili R, Holinstat M, Eniola-Adefeso O. Cargo-free particles divert neutrophil-platelet aggregates to reduce thromboinflammation. Nat Commun. 2023 04 28; 14(1):2462. PMID: 37117163.
      Citations:    
    19. La CC, Smith SA, Vappala S, Adili R, Luke CE, Abbina S, Luo HD, Chafeeva I, Drayton M, Creagh LA, de Guadalupe Jaraquemada-Pel?ez M, Rhoads N, Kalathottukaren MT, Henke PK, Straus SK, Du C, Conway EM, Holinstat M, Haynes CA, Morrissey JH, Kizhakkedathu JN. Smart thrombosis inhibitors without bleeding side effects via charge tunable ligand design. Nat Commun. 2023 04 26; 14(1):2177. PMID: 37100783.
      Citations:    
    20. Stanger L, Holinstat M. Bioactive lipid regulation of platelet function, hemostasis, and thrombosis. Pharmacol Ther. 2023 06; 246:108420. PMID: 37100208.
      Citations:    
    21. Sharma SB, Melvin WJ, Audu CO, Bame M, Rhoads N, Wu W, Kanthi Y, Knight JS, Adili R, Holinstat MA, Wakefield TW, Henke PK, Moore BB, Gallagher KA, Obi AT. The histone methyltransferase MLL1/KMT2A in monocytes drives coronavirus-associated coagulopathy and inflammation. Blood. 2023 02 16; 141(7):725-742. PMID: 36493338.
      Citations:    
    22. Yamaguchi A, van Hoorebeke C, Tourdot BE, Perry SC, Lee G, Rhoads N, Rickenberg A, Green AR, Sorrentino J, Yeung J, Freedman JC, Holman TR, Holinstat M. Fatty acids negatively regulate platelet function through formation of noncanonical 15-lipoxygenase-derived eicosanoids. Pharmacol Res Perspect. 2023 02; 11(1):e01056. PMID: 36708179.
      Citations:    
    23. Tran M, Signorelli RL, Yamaguchi A, Chen E, Holinstat M, Iavarone AT, Offenbacher AR, Holman T. Biochemical and hydrogen-deuterium exchange studies of the single nucleotide polymorphism Y649C in human platelet 12-lipoxygenase linked to a bleeding disorder. Arch Biochem Biophys. 2023 01 01; 733:109472. PMID: 36442529.
      Citations:    
    24. Yamaguchi A, Botta E, Holinstat M. Eicosanoids in inflammation in the blood and the vessel. Front Pharmacol. 2022; 13:997403. PMID: 36238558.
      Citations:    
    25. Holinstat M. Trauma is an exhausting platelet experience. J Thromb Haemost. 2022 09; 20(9):1986-1987. PMID: 35968791.
      Citations:    
    26. Yu M, Hong K, Adili R, Mei L, Liu L, He H, Guo Y, Chen YE, Holinstat M, Schwendeman A. Development of activated endothelial targeted high-density lipoprotein nanoparticles. Front Pharmacol. 2022; 13:902269. PMID: 36105190.
      Citations:    
    27. Yamaguchi A, Stanger L, Freedman JC, Prieur A, Thav R, Tena J, Holman TR, Holinstat M. Supplementation with omega-3 or omega-6 fatty acids attenuates platelet reactivity in postmenopausal women. Clin Transl Sci. 2022 10; 15(10):2378-2391. PMID: 35791734.
      Citations:    
    28. Frame D, Scappaticci GB, Braun TM, Maliarik M, Sisson TH, Pipe SW, Lawrence DA, Richardson PG, Holinstat M, Hyzy RC, Kaul DR, Gregg KS, Lama VN, Yanik GA. Defibrotide Therapy for SARS-CoV-2 ARDS. Chest. 2022 08; 162(2):346-355. PMID: 35413279.
      Citations:    
    29. Darga EP, Dolce EM, Fang F, Kidwell KM, Gersch CL, Kregel S, Thomas DG, Gill A, Brown ME, Gross S, Connelly M, Holinstat M, Cobain EF, Rae JM, Hayes DF, Paoletti C. PD-L1 expression on circulating tumor cells and platelets in patients with metastatic breast cancer. PLoS One. 2021; 16(11):e0260124. PMID: 34780566.
      Citations:    
    30. Holinstat M. Controlling the Clot: ANXA7 Regulates Collagen Activation of Platelet Through 12-LOX. Circ Res. 2021 08 06; 129(4):508-510. PMID: 34351797.
      Citations:    
    31. Duan X, Perveen R, Dandamudi A, Adili R, Johnson J, Funk K, Berryman M, Davis AK, Holinstat M, Zheng Y, Akbar H. Pharmacologic targeting of Cdc42 GTPase by a small molecule Cdc42 activity-specific inhibitor prevents platelet activation and thrombosis. Sci Rep. 2021 06 23; 11(1):13170. PMID: 34162972.
      Citations:    
    32. Tsai WC, Kalyanaraman C, Yamaguchi A, Holinstat M, Jacobson MP, Holman TR. In Vitro Biosynthetic Pathway Investigations of Neuroprotectin D1 (NPD1) and Protectin DX (PDX) by Human 12-Lipoxygenase, 15-Lipoxygenase-1, and 15-Lipoxygenase-2. Biochemistry. 2021 06 08; 60(22):1741-1754. PMID: 34029049.
      Citations:    
    33. Fish MB, Banka AL, Braunreuther M, Fromen CA, Kelley WJ, Lee J, Adili R, Holinstat M, Eniola-Adefeso O. Deformable microparticles for shuttling nanoparticles to the vascular wall. Sci Adv. 2021 04; 7(17). PMID: 33883129.
      Citations:    
    34. Myers DD, Ning J, Lester P, Adili R, Hawley A, Durham L, Dunivant V, Reynolds G, Crego K, Sood S, Sigler R, Fogler WE, Magnani JL, Holinstat M, Wakefield T. E-selectin inhibitor is superior to low-molecular-weight heparin for the treatment of experimental venous thrombosis. J Vasc Surg Venous Lymphat Disord. 2022 01; 10(1):211-220. PMID: 33872819.
      Citations:    
    35. Pitt B, Sutton NR, Wang Z, Goonewardena SN, Holinstat M. Potential repurposing of the HDAC inhibitor valproic acid for patients with COVID-19. Eur J Pharmacol. 2021 May 05; 898:173988. PMID: 33667455.
      Citations:    
    36. Zaslavsky A, Adams M, Cao X, Yamaguchi A, Henderson J, Busch-?stergren P, Udager A, Pitchiaya S, Tourdot B, Kasputis T, Church SJ, Lee SK, Ohl S, Patel S, Morgan TM, Alva A, Wakefield TW, Reichert Z, Holinstat M, Palapattu GS. Antisense oligonucleotides and nucleic acids generate hypersensitive platelets. Thromb Res. 2021 04; 200:64-71. PMID: 33540294.
      Citations:    
    37. Adili R, Jackson M, Stanger L, Dai X, Li M, Li BX, Holinstat M. Slounase, a Batroxobin Containing Activated Factor X Effectively Enhances Hemostatic Clot Formation and Reducing Bleeding in Hypocoagulant Conditions in Mice. Clin Appl Thromb Hemost. 2021 Jan-Dec; 27:10760296211018510. PMID: 34047195.
      Citations:    
    38. Yamaguchi A, Stanger L, Freedman CJ, Standley M, Hoang T, Adili R, Tsai WC, van Hoorebeke C, Holman TR, Holinstat M. DHA 12-LOX-derived oxylipins regulate platelet activation and thrombus formation through a PKA-dependent signaling pathway. J Thromb Haemost. 2021 03; 19(3):839-851. PMID: 33222370.
      Citations:    
    39. He H, Adili R, Liu L, Hong K, Holinstat M, Schwendeman A. Synthetic high-density lipoproteins loaded with an antiplatelet drug for efficient inhibition of thrombosis in mice. Sci Adv. 2020 12; 6(49). PMID: 33277254.
      Citations:    
    40. Holinstat M. Popping the lid on PAR4 activation. Blood. 2020 11 05; 136(19):2101-2102. PMID: 33152086.
      Citations:    
    41. Yeung J, Adili R, Stringham EN, Luo R, Vizurraga A, Rosselli-Murai LK, Stoveken HM, Yu M, Piao X, Holinstat M, Tall GG. GPR56/ADGRG1 is a platelet collagen-responsive GPCR and hemostatic sensor of shear force. Proc Natl Acad Sci U S A. 2020 11 10; 117(45):28275-28286. PMID: 33097663.
      Citations:    
    42. Perry SC, Horn T, Tourdot BE, Yamaguchi A, Kalyanaraman C, Conrad WS, Akinkugbe O, Holinstat M, Jacobson MP, Holman TR. Role of Human 15-Lipoxygenase-2 in the Biosynthesis of the Lipoxin Intermediate, 5S,15S-diHpETE, Implicated with the Altered Positional Specificity of Human 15-Lipoxygenase-1. Biochemistry. 2020 10 27; 59(42):4118-4130. PMID: 33048542.
      Citations:    
    43. Yeung J, Adili R, Yamaguchi A, Freedman CJ, Chen A, Shami R, Das A, Holman TR, Holinstat M. Omega-6 DPA and its 12-lipoxygenase-oxidized lipids regulate platelet reactivity in a nongenomic PPARa-dependent manner. Blood Adv. 2020 09 22; 4(18):4522-4537. PMID: 32946570.
      Citations:    
    44. Perry SC, Kalyanaraman C, Tourdot BE, Conrad WS, Akinkugbe O, Freedman JC, Holinstat M, Jacobson MP, Holman TR. 15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-lipoxygenase-2 in biosynthesis of resolvin D5. J Lipid Res. 2020 07; 61(7):1087-1103. PMID: 32404334.
      Citations:    
    45. Freedman C, Tran A, Tourdot BE, Kalyanaraman C, Perry S, Holinstat M, Jacobson MP, Holman TR. Biosynthesis of the Maresin Intermediate, 13S,14S-Epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and Its Regulation through Negative Allosteric Modulators. Biochemistry. 2020 05 19; 59(19):1832-1844. PMID: 32324389.
      Citations:    
    46. Myers D, Lester P, Adili R, Hawley A, Durham L, Dunivant V, Reynolds G, Crego K, Zimmerman Z, Sood S, Sigler R, Fogler W, Magnani J, Holinstat M, Wakefield T. A new way to treat proximal deep venous thrombosis using E-selectin inhibition. J Vasc Surg Venous Lymphat Disord. 2020 03; 8(2):268-278. PMID: 32067728.
      Citations:    
    47. Holinstat M. Resolvin the clot: DVT resolution through RvD4. Blood. 2019 10 24; 134(17):1370-1371. PMID: 31698428.
      Citations:    
    48. Adili R, Holinstat M. Formation and Resolution of Pial Microvascular Thrombosis in a Mouse Model of Thrombotic Thrombocytopenic Purpura. Arterioscler Thromb Vasc Biol. 2019 09; 39(9):1817-1830. PMID: 31340669.
      Citations:    
    49. Yadav V, Chi L, Zhao R, Tourdot BE, Yalavarthi S, Jacobs BN, Banka A, Liao H, Koonse S, Anyanwu AC, Visovatti SH, Holinstat MA, Kahlenberg JM, Knight JS, Pinsky DJ, Kanthi Y. Ectonucleotidase tri(di)phosphohydrolase-1 (ENTPD-1) disrupts inflammasome/interleukin 1?-driven venous thrombosis. J Clin Invest. 2019 04 16; 129(7):2872-2877. PMID: 30990798.
      Citations:    
    50. Liang W, Fan Y, Lu H, Chang Z, Hu W, Sun J, Wang H, Zhu T, Wang J, Adili R, Garcia-Barrio MT, Holinstat M, Eitzman D, Zhang J, Chen YE. KLF11 (Kr?ppel-Like Factor 11) Inhibits Arterial Thrombosis via Suppression of Tissue Factor in the Vascular Wall. Arterioscler Thromb Vasc Biol. 2019 03; 39(3):402-412. PMID: 30602303.
      Citations:    
    51. Rost MS, Shestopalov I, Liu Y, Vo AH, Richter CE, Emly SM, Barrett FG, Stachura DL, Holinstat M, Zon LI, Shavit JA. Nfe2 is dispensable for early but required for adult thrombocyte formation and function in zebrafish. Blood Adv. 2018 12 11; 2(23):3418-3427. PMID: 30504234.
      Citations:    
    52. Green AR, Freedman C, Tena J, Tourdot BE, Liu B, Holinstat M, Holman TR. 5 S,15 S-Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a Lipoxin Intermediate: Reactivity and Kinetics with Human Leukocyte 5-Lipoxygenase, Platelet 12-Lipoxygenase, and Reticulocyte 15-Lipoxygenase-1. Biochemistry. 2018 12 04; 57(48):6726-6734. PMID: 30407793.
      Citations:    
    53. Tilburg J, Adili R, Nair TS, Hawley ME, Tuk DC, Jackson M, Spronk HM, Versteeg HH, Carey TE, van Vlijmen BJM, Maracle CX, Holinstat M. Characterization of hemostasis in mice lacking the novel thrombosis susceptibility gene Slc44a2. Thromb Res. 2018 11; 171:155-159. PMID: 30312801.
      Citations:    
    54. Adili R, Hawley M, Holinstat M. Regulation of platelet function and thrombosis by omega-3 and omega-6 polyunsaturated fatty acids. Prostaglandins Other Lipid Mediat. 2018 11; 139:10-18. PMID: 30266534.
      Citations:    
    55. Yeung J, Li W, Holinstat M. Platelet Signaling and Disease: Targeted Therapy for Thrombosis and Other Related Diseases. Pharmacol Rev. 2018 07; 70(3):526-548. PMID: 29925522.
      Citations:    
    56. Tourdot BE, Stoveken H, Trumbo D, Yeung J, Kanthi Y, Edelstein LC, Bray PF, Tall GG, Holinstat M. Genetic Variant in Human PAR (Protease-Activated Receptor) 4 Enhances Thrombus Formation Resulting in Resistance to Antiplatelet Therapeutics. Arterioscler Thromb Vasc Biol. 2018 07; 38(7):1632-1643. PMID: 29748334.
      Citations:    
    57. Holinstat M. New LINE(s) of Evidence for Genetic Regulation of Platelets. Arterioscler Thromb Vasc Biol. 2018 04; 38(4):690-691. PMID: 29563112.
      Citations:    
    58. Safari H, Adili R, Holinstat M, Eniola-Adefeso O. Modified two-step emulsion solvent evaporation technique for fabricating biodegradable rod-shaped particles in the submicron size range. J Colloid Interface Sci. 2018 May 15; 518:174-183. PMID: 29454188.
      Citations:    
    59. Adili R, Voigt EM, Bormann JL, Foss KN, Hurley LJ, Meyer ES, Veldman AJ, Mast KA, West JL, Whiteheart SW, Holinstat M, Larson MK. In vivo modeling of docosahexaenoic acid and eicosapentaenoic acid-mediated inhibition of both platelet function and accumulation in arterial thrombi. Platelets. 2019; 30(2):271-279. PMID: 29286871.
      Citations:    
    60. Fromen CA, Kelley WJ, Fish MB, Adili R, Noble J, Hoenerhoff MJ, Holinstat M, Eniola-Adefeso O. Neutrophil-Particle Interactions in Blood Circulation Drive Particle Clearance and Alter Neutrophil Responses in Acute Inflammation. ACS Nano. 2017 11 28; 11(11):10797-10807. PMID: 29028303.
      Citations:    
    61. Tourdot BE, Holinstat M. Targeting 12-Lipoxygenase as a Potential Novel Antiplatelet Therapy. Trends Pharmacol Sci. 2017 11; 38(11):1006-1015. PMID: 28863985.
      Citations:    
    62. Adili R, Tourdot BE, Mast K, Yeung J, Freedman JC, Green A, Luci DK, Jadhav A, Simeonov A, Maloney DJ, Holman TR, Holinstat M. First Selective 12-LOX Inhibitor, ML355, Impairs Thrombus Formation and Vessel Occlusion In Vivo With Minimal Effects on Hemostasis. Arterioscler Thromb Vasc Biol. 2017 10; 37(10):1828-1839. PMID: 28775075.
      Citations:    
    63. McDougle DR, Watson JE, Abdeen AA, Adili R, Caputo MP, Krapf JE, Johnson RW, Kilian KA, Holinstat M, Das A. Anti-inflammatory ?-3 endocannabinoid epoxides. Proc Natl Acad Sci U S A. 2017 07 25; 114(30):E6034-E6043. PMID: 28687674.
      Citations:    
    64. Tourdot BE, Adili R, Isingizwe ZR, Ebrahem M, Freedman JC, Holman TR, Holinstat M. 12-HETrE inhibits platelet reactivity and thrombosis in part through the prostacyclin receptor. Blood Adv. 2017 Jun 27; 1(15):1124-1131. PMID: 29296755.
      Citations:    
    65. Holinstat M. Normal platelet function. Cancer Metastasis Rev. 2017 06; 36(2):195-198. PMID: 28667366.
      Citations:    
    66. Yeung J, Hawley M, Holinstat M. The expansive role of oxylipins on platelet biology. J Mol Med (Berl). 2017 06; 95(6):575-588. PMID: 28528513.
      Citations:    
    67. Holinstat M. Complement factors (H) into thrombosis. Blood. 2017 03 02; 129(9):1065-1066. PMID: 28254823.
      Citations:    
    68. Kong X, Simon LM, Holinstat M, Shaw CA, Bray PF, Edelstein LC. Identification of a functional genetic variant driving racially dimorphic platelet gene expression of the thrombin receptor regulator, PCTP. Thromb Haemost. 2017 05 03; 117(5):962-970. PMID: 28251237.
      Citations:    
    69. Yeung J, Holinstat M. Who is the real 12-HETrE? Prostaglandins Other Lipid Mediat. 2017 09; 132:25-30. PMID: 28259546.
      Citations:    
    70. Fish MB, Fromen CA, Lopez-Cazares G, Golinski AW, Scott TF, Adili R, Holinstat M, Eniola-Adefeso O. Exploring deformable particles in vascular-targeted drug delivery: Softer is only sometimes better. Biomaterials. 2017 04; 124:169-179. PMID: 28209527.
      Citations:    
    71. Roy J, Adili R, Kulmacz R, Holinstat M, Das A. Development of Poly Unsaturated Fatty Acid Derivatives of Aspirin for Inhibition of Platelet Function. J Pharmacol Exp Ther. 2016 10; 359(1):134-41. PMID: 27488919.
      Citations:    
    72. Yeung J, Tourdot BE, Adili R, Green AR, Freedman CJ, Fernandez-Perez P, Yu J, Holman TR, Holinstat M. 12(S)-HETrE, a 12-Lipoxygenase Oxylipin of Dihomo-?-Linolenic Acid, Inhibits Thrombosis via Gas Signaling in Platelets. Arterioscler Thromb Vasc Biol. 2016 10; 36(10):2068-77. PMID: 27470510.
      Citations:    
    73. Fromen CA, Fish MB, Zimmerman A, Adili R, Holinstat M, Eniola-Adefeso O. Evaluation of Receptor-Ligand Mechanisms of Dual-Targeted Particles to an Inflamed Endothelium. Bioeng Transl Med. 2016 Mar; 1(1):103-115. PMID: 28066821.
      Citations:    
    74. Holinstat M, Reheman A. Dual antiplatelet therapy for PCI: Are we tailored to all? Thromb Res. 2015 Jun; 135(6):1045-6. PMID: 25900309.
      Citations:    
    75. Holinstat M, Tourdot BE. Coronary heart disease risk factors take a disproportional toll on women. Arterioscler Thromb Vasc Biol. 2015 Apr; 35(4):750-1. PMID: 25810295.
      Citations:    
    76. Edelstein LC, Simon LM, Lindsay CR, Kong X, Teruel-Montoya R, Tourdot BE, Chen ES, Ma L, Coughlin S, Nieman M, Holinstat M, Shaw CA, Bray PF. Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race. Blood. 2014 Nov 27; 124(23):3450-8. PMID: 25293779.
      Citations:    
    77. Tourdot BE, Conaway S, Niisuke K, Edelstein LC, Bray PF, Holinstat M. Mechanism of race-dependent platelet activation through the protease-activated receptor-4 and Gq signaling axis. Arterioscler Thromb Vasc Biol. 2014 Dec; 34(12):2644-50. PMID: 25278289.
      Citations:    
    78. Yeung J, Tourdot BE, Fernandez-Perez P, Vesci J, Ren J, Smyrniotis CJ, Luci DK, Jadhav A, Simeonov A, Maloney DJ, Holman TR, McKenzie SE, Holinstat M. Platelet 12-LOX is essential for Fc?RIIa-mediated platelet activation. Blood. 2014 Oct 02; 124(14):2271-9. PMID: 25100742.
      Citations:    
    79. Cleator JH, Duvernay MT, Holinstat M, Colowick NE, Hudson WJ, Song Y, Harrell FE, Hamm HE. Racial differences in resistance to P2Y12 receptor antagonists in type 2 diabetic subjects. J Pharmacol Exp Ther. 2014 Oct; 351(1):33-43. PMID: 25052834.
      Citations:    
    80. Teruel-Montoya R, Kong X, Abraham S, Ma L, Kunapuli SP, Holinstat M, Shaw CA, McKenzie SE, Edelstein LC, Bray PF. MicroRNA expression differences in human hematopoietic cell lineages enable regulated transgene expression. PLoS One. 2014; 9(7):e102259. PMID: 25029370.
      Citations:    
    81. Simon LM, Edelstein LC, Nagalla S, Woodley AB, Chen ES, Kong X, Ma L, Fortina P, Kunapuli S, Holinstat M, McKenzie SE, Dong JF, Shaw CA, Bray PF. Human platelet microRNA-mRNA networks associated with age and gender revealed by integrated plateletomics. Blood. 2014 Apr 17; 123(16):e37-45. PMID: 24523238.
      Citations:    
    82. Tourdot BE, Ahmed I, Holinstat M. The emerging role of oxylipins in thrombosis and diabetes. Front Pharmacol. 2014 Jan 07; 4:176. PMID: 24432004.
      Citations:    
    83. Luci DK, Jameson JB, Yasgar A, Diaz G, Joshi N, Kantz A, Markham K, Perry S, Kuhn N, Yeung J, Kerns EH, Schultz L, Holinstat M, Nadler JL, Taylor-Fishwick DA, Jadhav A, Simeonov A, Holman TR, Maloney DJ. Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase. J Med Chem. 2014 Jan 23; 57(2):495-506. PMID: 24393039.
      Citations:    
    84. Edelstein LC, Simon LM, Montoya RT, Holinstat M, Chen ES, Bergeron A, Kong X, Nagalla S, Mohandas N, Cohen DE, Dong JF, Shaw C, Bray PF. Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c. Nat Med. 2013 Dec; 19(12):1609-16. PMID: 24216752.
      Citations:    
    85. Edelstein LC, McKenzie SE, Shaw C, Holinstat MA, Kunapuli SP, Bray PF. MicroRNAs in platelet production and activation. J Thromb Haemost. 2013 Jun; 11 Suppl 1:340-50. PMID: 23809137.
      Citations:    
    86. Holinstat M, Colowick NE, Hudson WJ, Blakemore D, Chen Q, Hamm HE, Cleator JH. Dichotomous effects of exposure to bivalirudin in patients undergoing percutaneous coronary intervention on protease-activated receptor-mediated platelet activation. J Thromb Thrombolysis. 2013 Feb; 35(2):209-22. PMID: 23054462.
      Citations:    
    87. Ikei KN, Yeung J, Apopa PL, Ceja J, Vesci J, Holman TR, Holinstat M. Investigations of human platelet-type 12-lipoxygenase: role of lipoxygenase products in platelet activation. J Lipid Res. 2012 Dec; 53(12):2546-59. PMID: 22984144.
      Citations:    
    88. Yeung J, Holinstat M. Newer agents in antiplatelet therapy: a review. J Blood Med. 2012; 3:33-42. PMID: 22792011.
      Citations:    
    89. Yeung J, Apopa PL, Vesci J, Kenyon V, Rai G, Jadhav A, Simeonov A, Holman TR, Maloney DJ, Boutaud O, Holinstat M. Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation. Mol Pharmacol. 2012 Mar; 81(3):420-30. PMID: 22155783.
      Citations:    
    90. Pawlinski R, Holinstat M. We can do it together: PAR1/PAR2 heterodimer signaling in VSMCs. Arterioscler Thromb Vasc Biol. 2011 Dec; 31(12):2775-6. PMID: 22096094.
      Citations:    
    91. Stefanini L, Boulaftali Y, Ouellette TD, Holinstat M, D?sir? L, Leblond B, Andre P, Conley PB, Bergmeier W. Rap1-Rac1 circuits potentiate platelet activation. Arterioscler Thromb Vasc Biol. 2012 Feb; 32(2):434-41. PMID: 22075250.
      Citations:    
    92. Kenyon V, Rai G, Jadhav A, Schultz L, Armstrong M, Jameson JB, Perry S, Joshi N, Bougie JM, Leister W, Taylor-Fishwick DA, Nadler JL, Holinstat M, Simeonov A, Maloney DJ, Holman TR. Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase. J Med Chem. 2011 Aug 11; 54(15):5485-97. PMID: 21739938.
      Citations:    
    93. Yeung J, Holinstat M. 12-lipoxygenase: a potential target for novel anti-platelet therapeutics. Cardiovasc Hematol Agents Med Chem. 2011 Jul 01; 9(3):154-64. PMID: 21838667.
      Citations:    
    94. Holinstat M, Boutaud O, Apopa PL, Vesci J, Bala M, Oates JA, Hamm HE. Protease-activated receptor signaling in platelets activates cytosolic phospholipase A2a differently for cyclooxygenase-1 and 12-lipoxygenase catalysis. Arterioscler Thromb Vasc Biol. 2011 Feb; 31(2):435-42. PMID: 21127289.
      Citations:    
    95. Minshall RD, Vandenbroucke EE, Holinstat M, Place AT, Tiruppathi C, Vogel SM, van Nieuw Amerongen GP, Mehta D, Malik AB. Role of protein kinase Czeta in thrombin-induced RhoA activation and inter-endothelial gap formation of human dermal microvessel endothelial cell monolayers. Microvasc Res. 2010 Sep; 80(2):240-9. PMID: 20417648.
      Citations:    
    96. Holinstat M, Preininger AM, Milne SB, Hudson WJ, Brown HA, Hamm HE. Irreversible platelet activation requires protease-activated receptor 1-mediated signaling to phosphatidylinositol phosphates. Mol Pharmacol. 2009 Aug; 76(2):301-13. PMID: 19483102.
      Citations:    
    97. Voss B, McLaughlin JN, Holinstat M, Zent R, Hamm HE. PAR1, but not PAR4, activates human platelets through a Gi/o/phosphoinositide-3 kinase signaling axis. Mol Pharmacol. 2007 May; 71(5):1399-406. PMID: 17303701.
      Citations:    
    98. Holinstat M, Voss B, Bilodeau ML, Hamm HE. Protease-activated receptors differentially regulate human platelet activation through a phosphatidic acid-dependent pathway. Mol Pharmacol. 2007 Mar; 71(3):686-94. PMID: 17151288.
      Citations:    
    99. Holinstat M, Oldham WM, Hamm HE. G-protein-coupled receptors: evolving views on physiological signalling: symposium on G-protein-coupled receptors: evolving concepts and new techniques. EMBO Rep. 2006 Sep; 7(9):866-9. PMID: 16906127.
      Citations:    
    100. Holinstat M, Voss B, Bilodeau ML, McLaughlin JN, Cleator J, Hamm HE. PAR4, but not PAR1, signals human platelet aggregation via Ca2+ mobilization and synergistic P2Y12 receptor activation. J Biol Chem. 2006 Sep 08; 281(36):26665-74. PMID: 16837456.
      Citations:    
    101. Holinstat M, Knezevic N, Broman M, Samarel AM, Malik AB, Mehta D. Suppression of RhoA activity by focal adhesion kinase-induced activation of p190RhoGAP: role in regulation of endothelial permeability. J Biol Chem. 2006 Jan 27; 281(4):2296-305. PMID: 16308318.
      Citations:    
    102. McLaughlin JN, Shen L, Holinstat M, Brooks JD, Dibenedetto E, Hamm HE. Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-activated receptor-1. J Biol Chem. 2005 Jul 01; 280(26):25048-59. PMID: 15878870.
      Citations:    
    103. Park TJ, Klug A, Holinstat M, Grothe B. Interaural level difference processing in the lateral superior olive and the inferior colliculus. J Neurophysiol. 2004 Jul; 92(1):289-301. PMID: 15056693.
      Citations:    
    104. Ahmmed GU, Mehta D, Vogel S, Holinstat M, Paria BC, Tiruppathi C, Malik AB. Protein kinase Calpha phosphorylates the TRPC1 channel and regulates store-operated Ca2+ entry in endothelial cells. J Biol Chem. 2004 May 14; 279(20):20941-9. PMID: 15016832.
      Citations:    
    105. Mehta D, Ahmmed GU, Paria BC, Holinstat M, Voyno-Yasenetskaya T, Tiruppathi C, Minshall RD, Malik AB. RhoA interaction with inositol 1,4,5-trisphosphate receptor and transient receptor potential channel-1 regulates Ca2+ entry. Role in signaling increased endothelial permeability. J Biol Chem. 2003 Aug 29; 278(35):33492-500. PMID: 12766172.
      Citations:    
    106. Holinstat M, Mehta D, Kozasa T, Minshall RD, Malik AB. Protein kinase Calpha-induced p115RhoGEF phosphorylation signals endothelial cytoskeletal rearrangement. J Biol Chem. 2003 Aug 01; 278(31):28793-8. PMID: 12754211.
      Citations:    
    107. Mehta D, Tiruppathi C, Sandoval R, Minshall RD, Holinstat M, Malik AB. Modulatory role of focal adhesion kinase in regulating human pulmonary arterial endothelial barrier function. J Physiol. 2002 Mar 15; 539(Pt 3):779-89. PMID: 11897849.
      Citations:    
    Holinstat's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (428)
    Explore
    _
    Co-Authors (10)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _
    Physical Neighbors
    _