Michael Holinstat

TitleAsst Professor
InstitutionThomas Jefferson University
DepartmentHematology
Address1015 Walnut St.
Philadelphia PA 19107
vCardDownload vCard

    Collapse Research 
    Collapse research activities and funding
    F32HL082068     (HOLINSTAT, MICHAEL ALLAN)Aug 1, 2005 - Jul 31, 2007
    NIH
    PAR mediated Rap 1 activation in platelets
    Role: Principal Investigator

    R00HL089457     (HOLINSTAT, MICHAEL ALLAN)Aug 1, 2007 - Apr 30, 2012
    NIH
    Thrombin regulation of Rap1 signaling in human platelet activity
    Role: Principal Investigator

    K99HL089457     (HOLINSTAT, MICHAEL ALLAN)Aug 1, 2007 - Jul 31, 2012
    NIH
    Thrombin regulation of Rap1 signaling in human platelet activity
    Role: Principal Investigator

    R01MD007880     (BRAY, PAUL F.)Jul 9, 2013 - Feb 28, 2019
    NIH
    Genetic regulation of racial differences in platelet reactivity
    Role: Co-Principal Investigator

    R01HL114405     (HOLINSTAT, MICHAEL ALLAN)Aug 1, 2013 - May 31, 2018
    NIH
    Role of 12-lipoxygenase in platelet reactivity and type 2 diabetes mellitus
    Role: Principal Investigator

    R01GM105671     (HOLINSTAT, MICHAEL ALLAN)Aug 1, 2013 - Jul 31, 2019
    NIH
    12-HETrE regulation of platelets
    Role: Principal Investigator

    TL1TR002242     (HOLINSTAT, MICHAEL ALLAN)Jun 1, 2017 - Feb 28, 2022
    NIH
    NRSA Training Core
    Role: Principal Investigator

    R35GM131835     (HOLINSTAT, MICHAEL ALLAN)Apr 1, 2019 - Mar 31, 2024
    NIH
    12-HETrE regulation of blood coagulation, hemostasis, and thrombosis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Fish MB, Banka AL, Braunreuther M, Fromen CA, Kelley WJ, Lee J, Adili R, Holinstat M, Eniola-Adefeso O. Deformable microparticles for shuttling nanoparticles to the vascular wall. Sci Adv. 2021 Apr; 7(17). PMID: 33883129.
      Citations:    
    2. Myers DD, Ning J, Lester P, Adili R, Hawley A, Durham L, Dunivant V, Reynolds G, Crego K, Sood S, Sigler R, Fogler WE, Magnani JL, Holinstat M, Wakefield T. E-selectin Inhibitor is Superior to LMWH for Treatment of Experimental Venous Thrombosis. J Vasc Surg Venous Lymphat Disord. 2021 Apr 16. PMID: 33872819.
      Citations:    
    3. Pitt B, Sutton NR, Wang Z, Goonewardena SN, Holinstat M. Potential repurposing of the HDAC inhibitor valproic acid for patients with COVID-19. Eur J Pharmacol. 2021 May 05; 898:173988. PMID: 33667455.
      Citations:    
    4. Zaslavsky A, Adams M, Cao X, Yamaguchi A, Henderson J, Busch-Østergren P, Udager A, Pitchiaya S, Tourdot B, Kasputis T, Church SJ, Lee SK, Ohl S, Patel S, Morgan TM, Alva A, Wakefield TW, Reichert Z, Holinstat M, Palapattu GS. Antisense oligonucleotides and nucleic acids generate hypersensitive platelets. Thromb Res. 2021 04; 200:64-71. PMID: 33540294.
      Citations:    
    5. He H, Adili R, Liu L, Hong K, Holinstat M, Schwendeman A. Synthetic high-density lipoproteins loaded with an antiplatelet drug for efficient inhibition of thrombosis in mice. Sci Adv. 2020 Dec; 6(49). PMID: 33277254.
      Citations:    
    6. Yamaguchi A, Stanger L, Freedman CJ, Standley M, Hoang T, Adili R, Tsai WC, van Hoorebeke C, Holman TR, Holinstat M. DHA 12-LOX-derived oxylipins regulate platelet activation and thrombus formation through a PKA-dependent signaling pathway. J Thromb Haemost. 2020 Nov 21. PMID: 33222370.
      Citations:    
    7. Holinstat M. Popping the lid on PAR4 activation. Blood. 2020 Nov 05; 136(19):2101-2102. PMID: 33152086.
      Citations:    
    8. Yeung J, Adili R, Stringham EN, Luo R, Vizurraga A, Rosselli-Murai LK, Stoveken HM, Yu M, Piao X, Holinstat M, Tall GG. GPR56/ADGRG1 is a platelet collagen-responsive GPCR and hemostatic sensor of shear force. Proc Natl Acad Sci U S A. 2020 11 10; 117(45):28275-28286. PMID: 33097663.
      Citations:    
    9. Perry SC, Horn T, Tourdot BE, Yamaguchi A, Kalyanaraman C, Conrad WS, Akinkugbe O, Holinstat M, Jacobson MP, Holman TR. Role of Human 15-Lipoxygenase-2 in the Biosynthesis of the Lipoxin Intermediate, 5S,15S-diHpETE, Implicated with the Altered Positional Specificity of Human 15-Lipoxygenase-1. Biochemistry. 2020 Oct 27; 59(42):4118-4130. PMID: 33048542.
      Citations:    
    10. Yeung J, Adili R, Yamaguchi A, Freedman CJ, Chen A, Shami R, Das A, Holman TR, Holinstat M. Omega-6 DPA and its 12-lipoxygenase-oxidized lipids regulate platelet reactivity in a nongenomic PPARa-dependent manner. Blood Adv. 2020 Sep 22; 4(18):4522-4537. PMID: 32946570.
      Citations:    
    11. Perry SC, Kalyanaraman C, Tourdot BE, Conrad WS, Akinkugbe O, Freedman JC, Holinstat M, Jacobson MP, Holman TR. 15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-lipoxygenase-2 in biosynthesis of resolvin D5. J Lipid Res. 2020 Jul; 61(7):1087-1103. PMID: 32404334.
      Citations:    
    12. Freedman CJ, Tran A, Tourdot BE, Kalyanaraman C, Perry S, Holinstat M, Jacobson MP, Holman TR. Biosynthesis of the Maresin Intermediate, 13S,14S-epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and its Regulation through Negative Allosteric Modulators. Biochemistry. 2020 Apr 23. PMID: 32324389.
      Citations:    
    13. Myers D, Lester P, Adili R, Hawley A, Durham L, Dunivant V, Reynolds G, Crego K, Zimmerman Z, Sood S, Sigler R, Fogler W, Magnani J, Holinstat M, Wakefield T. A new way to treat proximal deep venous thrombosis using E-selectin inhibition. J Vasc Surg Venous Lymphat Disord. 2020 Mar; 8(2):268-278. PMID: 32067728.
      Citations:    
    14. Holinstat M. Resolvin the clot: DVT resolution through RvD4. Blood. 2019 Oct 24; 134(17):1370-1371. PMID: 31698428.
      Citations:    
    15. Adili R, Holinstat M. Formation and Resolution of Pial Microvascular Thrombosis in a Mouse Model of Thrombotic Thrombocytopenic Purpura. Arterioscler Thromb Vasc Biol. 2019 Sep; 39(9):1817-1830. PMID: 31340669.
      Citations:    
    16. Yadav V, Chi L, Zhao R, Tourdot B, Yalavarthi S, Jacobs BN, Banka A, Liao H, Koonse S, Anyanwu AC, Visovatti S, Holinstat M, Kahlenberg JM, Knight JS, Pinsky DJ, Kanthi Y. Ectonucleotidase tri(di)phosphohydrolase-1 (ENTPD-1) disrupts inflammasome/interleukin 1ß-driven venous thrombosis. J Clin Invest. 2019 Apr 16; 130. PMID: 30990798.
      Citations:    
    17. Liang W, Fan Y, Lu H, Chang Z, Hu W, Sun J, Wang H, Zhu T, Wang J, Adili R, Garcia-Barrio MT, Holinstat M, Eitzman D, Zhang J, Chen YE. KLF11 (Kruüppel-Like Factor 11) Inhibits Arterial Thrombosis via Suppression of Tissue Factor in the Vascular Wall. Arterioscler Thromb Vasc Biol. 2019 Jan 03; ATVBAHA118311612. PMID: 30602303.
      Citations:    
    18. Rost MS, Shestopalov I, Liu Y, Vo AH, Richter CE, Emly SM, Barrett FG, Stachura DL, Holinstat M, Zon LI, Shavit JA. Nfe2 is dispensable for early but required for adult thrombocyte formation and function in zebrafish. Blood Adv. 2018 Dec 11; 2(23):3418-3427. PMID: 30504234.
      Citations:    
    19. Green AR, Freedman C, Tena J, Tourdot BE, Liu B, Holinstat M, Holman TR. 5 S,15 S-Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a Lipoxin Intermediate: Reactivity and Kinetics with Human Leukocyte 5-Lipoxygenase, Platelet 12-Lipoxygenase, and Reticulocyte 15-Lipoxygenase-1. Biochemistry. 2018 Nov 15. PMID: 30407793.
      Citations:    
    20. Tilburg J, Adili R, Nair TS, Hawley ME, Tuk DC, Jackson M, Spronk HM, Versteeg HH, Carey TE, van Vlijmen BJM, Maracle CX, Holinstat M. Characterization of hemostasis in mice lacking the novel thrombosis susceptibility gene Slc44a2. Thromb Res. 2018 Sep 26; 171:155-159. PMID: 30312801.
      Citations:    
    21. Adili R, Hawley M, Holinstat M. Regulation of platelet function and thrombosis by omega-3 and omega-6 polyunsaturated fatty acids. Prostaglandins Other Lipid Mediat. 2018 Sep 25; 139:10-18. PMID: 30266534.
      Citations:    
    22. Yeung J, Li W, Holinstat M. Platelet Signaling and Disease: Targeted Therapy for Thrombosis and Other Related Diseases. Pharmacol Rev. 2018 Jul; 70(3):526-548. PMID: 29925522.
      Citations:    
    23. Tourdot BE, Stoveken H, Trumbo D, Yeung J, Kanthi Y, Edelstein LC, Bray PF, Tall GG, Holinstat M. Genetic Variant in Human PAR (Protease-Activated Receptor) 4 Enhances Thrombus Formation Resulting in Resistance to Antiplatelet Therapeutics. Arterioscler Thromb Vasc Biol. 2018 Jul; 38(7):1632-1643. PMID: 29748334.
      Citations:    
    24. Holinstat M. New LINE(s) of Evidence for Genetic Regulation of Platelets. Arterioscler Thromb Vasc Biol. 2018 Apr; 38(4):690-691. PMID: 29563112.
      Citations:    
    25. Safari H, Adili R, Holinstat M, Eniola-Adefeso O. Modified two-step emulsion solvent evaporation technique for fabricating biodegradable rod-shaped particles in the submicron size range. J Colloid Interface Sci. 2018 May 15; 518:174-183. PMID: 29454188.
      Citations:    
    26. Adili R, Voigt EM, Bormann JL, Foss KN, Hurley LJ, Meyer ES, Veldman AJ, Mast KA, West JL, Whiteheart SW, Holinstat M, Larson MK. In vivo modeling of docosahexaenoic acid and eicosapentaenoic acid-mediated inhibition of both platelet function and accumulation in arterial thrombi. Platelets. 2017 Dec 29; 1-9. PMID: 29286871.
      Citations:    
    27. Fromen CA, Kelley WJ, Fish MB, Adili R, Noble J, Hoenerhoff MJ, Holinstat M, Eniola-Adefeso O. Neutrophil-Particle Interactions in Blood Circulation Drive Particle Clearance and Alter Neutrophil Responses in Acute Inflammation. ACS Nano. 2017 Nov 28; 11(11):10797-10807. PMID: 29028303.
      Citations:    
    28. Tourdot BE, Holinstat M. Targeting 12-Lipoxygenase as a Potential Novel Antiplatelet Therapy. Trends Pharmacol Sci. 2017 11; 38(11):1006-1015. PMID: 28863985.
      Citations:    
    29. Adili R, Tourdot BE, Mast K, Yeung J, Freedman JC, Green A, Luci DK, Jadhav A, Simeonov A, Maloney DJ, Holman TR, Holinstat M. First Selective 12-LOX Inhibitor, ML355, Impairs Thrombus Formation and Vessel Occlusion In Vivo With Minimal Effects on Hemostasis. Arterioscler Thromb Vasc Biol. 2017 Aug 03. PMID: 28775075.
      Citations:    
    30. McDougle DR, Watson JE, Abdeen AA, Adili R, Caputo MP, Krapf JE, Johnson RW, Kilian KA, Holinstat M, Das A. Anti-inflammatory ?-3 endocannabinoid epoxides. Proc Natl Acad Sci U S A. 2017 Jul 07. PMID: 28687674.
      Citations:    
    31. Holinstat M. Normal platelet function. Cancer Metastasis Rev. 2017 Jun 30. PMID: 28667366.
      Citations:    
    32. Tourdot BE, Adili R, Isingizwe ZR, Ebrahem M, Freedman JC, Holman TR, Holinstat M. 12-HETrE inhibits platelet reactivity and thrombosis in part through the prostacyclin receptor. Blood Adv. 2017 Jun 27; 1(15):1124-1131. PMID: 29296755.
      Citations:    
    33. Yeung J, Hawley M, Holinstat M. The expansive role of oxylipins on platelet biology. J Mol Med (Berl). 2017 Jun; 95(6):575-588. PMID: 28528513.
      Citations:    
    34. Holinstat M. Complement factors (H) into thrombosis. Blood. 2017 Mar 02; 129(9):1065-1066. PMID: 28254823.
      Citations:    
    35. Kong X, Simon LM, Holinstat M, Shaw CA, Bray PF, Edelstein LC. Identification of a functional genetic variant driving racially dimorphic platelet gene expression of the thrombin receptor regulator, PCTP. Thromb Haemost. 2017 May 03; 117(5):962-970. PMID: 28251237.
      Citations:    
    36. Yeung J, Holinstat M. Who is the real 12-HETrE? Prostaglandins Other Lipid Mediat. 2017 Mar 01. PMID: 28259546.
      Citations:    
    37. Fish MB, Fromen CA, Lopez-Cazares G, Golinski AW, Scott TF, Adili R, Holinstat M, Eniola-Adefeso O. Exploring deformable particles in vascular-targeted drug delivery: Softer is only sometimes better. Biomaterials. 2017 Apr; 124:169-179. PMID: 28209527.
      Citations:    
    38. Roy J, Adili R, Kulmacz R, Holinstat M, Das A. Development of Poly Unsaturated Fatty Acid Derivatives of Aspirin for Inhibition of Platelet Function. J Pharmacol Exp Ther. 2016 Oct; 359(1):134-41. PMID: 27488919.
      Citations:    
    39. Yeung J, Tourdot BE, Adili R, Green AR, Freedman CJ, Fernandez-Perez P, Yu J, Holman TR, Holinstat M. 12(S)-HETrE, a 12-Lipoxygenase Oxylipin of Dihomo-?-Linolenic Acid, Inhibits Thrombosis via Gas Signaling in Platelets. Arterioscler Thromb Vasc Biol. 2016 Oct; 36(10):2068-77. PMID: 27470510.
      Citations:    
    40. Fromen CA, Fish MB, Zimmerman A, Adili R, Holinstat M, Eniola-Adefeso O. Evaluation of Receptor-Ligand Mechanisms of Dual-Targeted Particles to an Inflamed Endothelium. Bioeng Transl Med. 2016 Mar; 1(1):103-115. PMID: 28066821.
      Citations:    
    41. Holinstat M, Reheman A. Dual antiplatelet therapy for PCI: Are we tailored to all? Thromb Res. 2015 Jun; 135(6):1045-6. PMID: 25900309.
      Citations:    
    42. Holinstat M, Tourdot BE. Coronary heart disease risk factors take a disproportional toll on women. Arterioscler Thromb Vasc Biol. 2015 Apr; 35(4):750-1. PMID: 25810295.
      Citations:    
    43. Edelstein LC, Simon LM, Lindsay CR, Kong X, Teruel-Montoya R, Tourdot BE, Chen ES, Ma L, Coughlin S, Nieman M, Holinstat M, Shaw CA, Bray PF. Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race. Blood. 2014 Nov 27; 124(23):3450-8. PMID: 25293779.
      Citations:    
    44. Tourdot BE, Conaway S, Niisuke K, Edelstein LC, Bray PF, Holinstat M. Mechanism of race-dependent platelet activation through the protease-activated receptor-4 and gq signaling axis. Arterioscler Thromb Vasc Biol. 2014 Dec; 34(12):2644-50. PMID: 25278289.
      Citations:    
    45. Yeung J, Tourdot BE, Fernandez-Perez P, Vesci J, Ren J, Smyrniotis CJ, Luci DK, Jadhav A, Simeonov A, Maloney DJ, Holman TR, McKenzie SE, Holinstat M. Platelet 12-LOX is essential for Fc?RIIa-mediated platelet activation. Blood. 2014 Oct 2; 124(14):2271-9. PMID: 25100742.
      Citations:    
    46. Cleator JH, Duvernay MT, Holinstat M, Colowick NE, Hudson WJ, Song Y, Harrell FE, Hamm HE. Racial Differences in Resistance to P2Y12 Receptor Antagonists in Type 2 Diabetic Subjects. J Pharmacol Exp Ther. 2014 Oct; 351(1):33-43. PMID: 25052834.
      Citations:    
    47. Teruel-Montoya R, Kong X, Abraham S, Ma L, Kunapuli SP, Holinstat M, Shaw CA, McKenzie SE, Edelstein LC, Bray PF. MicroRNA Expression Differences in Human Hematopoietic Cell Lineages Enable Regulated Transgene Expression. PLoS One. 2014; 9(7):e102259. PMID: 25029370.
      Citations:    
    48. Simon LM, Edelstein LC, Nagalla S, Woodley AB, Chen ES, Kong X, Ma L, Fortina P, Kunapuli S, Holinstat M, McKenzie SE, Dong JF, Shaw CA, Bray PF. Human platelet microRNA-mRNA networks associated with age and gender revealed by integrated plateletomics. Blood. 2014 Apr 17; 123(16):e37-45. PMID: 24523238.
      Citations:    
    49. Tourdot BE, Ahmed I, Holinstat M. The emerging role of oxylipins in thrombosis and diabetes. Front Pharmacol. 2014 Jan 7; 4:176. PMID: 24432004.
      Citations:    
    50. Luci DK, Jameson JB, Yasgar A, Diaz G, Joshi N, Kantz A, Markham K, Perry S, Kuhn N, Yeung J, Kerns EH, Schultz L, Holinstat M, Nadler JL, Taylor-Fishwick DA, Jadhav A, Simeonov A, Holman TR, Maloney DJ. Synthesis and Structure-Activity Relationship Studies of 4-((2-Hydroxy-3-methoxybenzyl)amino)benzenesulfonamide Derivatives as Potent and Selective Inhibitors of 12-Lipoxygenase. J Med Chem. 2014 Jan 23; 57(2):495-506. PMID: 24393039.
      Citations:    
    51. Edelstein LC, Simon LM, Montoya RT, Holinstat M, Chen ES, Bergeron A, Kong X, Nagalla S, Mohandas N, Cohen DE, Dong JF, Shaw C, Bray PF. Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c. Nat Med. 2013 Dec; 19(12):1609-16. PMID: 24216752.
      Citations:    
    52. Edelstein LC, McKenzie SE, Shaw C, Holinstat MA, Kunapuli SP, Bray PF. MicroRNAs in platelet production and activation. J Thromb Haemost. 2013 Jun; 11 Suppl 1:340-50. PMID: 23809137.
      Citations:    
    53. Holinstat M, Colowick NE, Hudson WJ, Blakemore D, Chen Q, Hamm HE, Cleator JH. Dichotomous effects of exposure to bivalirudin in patients undergoing percutaneous coronary intervention on protease-activated receptor-mediated platelet activation. J Thromb Thrombolysis. 2013 Feb; 35(2):209-22. PMID: 23054462.
      Citations:    
    54. Ikei KN, Yeung J, Apopa PL, Ceja J, Vesci J, Holman TR, Holinstat M. Investigations of human platelet-type 12-lipoxygenase: role of lipoxygenase products in platelet activation. J Lipid Res. 2012 Dec; 53(12):2546-59. PMID: 22984144.
      Citations:    
    55. Yeung J, Holinstat M. Newer agents in antiplatelet therapy: a review. J Blood Med. 2012; 3:33-42. PMID: 22792011.
      Citations:    
    56. Yeung J, Apopa PL, Vesci J, Kenyon V, Rai G, Jadhav A, Simeonov A, Holman TR, Maloney DJ, Boutaud O, Holinstat M. Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation. Mol Pharmacol. 2012 Mar; 81(3):420-30. PMID: 22155783.
      Citations:    
    57. Pawlinski R, Holinstat M. We can do it together: PAR1/PAR2 heterodimer signaling in VSMCs. Arterioscler Thromb Vasc Biol. 2011 Dec; 31(12):2775-6. PMID: 22096094.
      Citations:    
    58. Stefanini L, Boulaftali Y, Ouellette TD, Holinstat M, Désiré L, Leblond B, Andre P, Conley PB, Bergmeier W. Rap1-Rac1 circuits potentiate platelet activation. Arterioscler Thromb Vasc Biol. 2012 Feb; 32(2):434-41. PMID: 22075250.
      Citations:    
    59. Kenyon V, Rai G, Jadhav A, Schultz L, Armstrong M, Jameson JB, Perry S, Joshi N, Bougie JM, Leister W, Taylor-Fishwick DA, Nadler JL, Holinstat M, Simeonov A, Maloney DJ, Holman TR. Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase. J Med Chem. 2011 Aug 11; 54(15):5485-97. PMID: 21739938.
      Citations:    
    60. Yeung J, Holinstat M. 12-lipoxygenase: a potential target for novel anti-platelet therapeutics. Cardiovasc Hematol Agents Med Chem. 2011 Jul 1; 9(3):154-64. PMID: 21838667.
      Citations:    
    61. Holinstat M, Boutaud O, Apopa PL, Vesci J, Bala M, Oates JA, Hamm HE. Protease-activated receptor signaling in platelets activates cytosolic phospholipase A2a differently for cyclooxygenase-1 and 12-lipoxygenase catalysis. Arterioscler Thromb Vasc Biol. 2011 Feb; 31(2):435-42. PMID: 21127289.
      Citations:    
    62. Minshall RD, Vandenbroucke EE, Holinstat M, Place AT, Tiruppathi C, Vogel SM, van Nieuw Amerongen GP, Mehta D, Malik AB. Role of protein kinase Czeta in thrombin-induced RhoA activation and inter-endothelial gap formation of human dermal microvessel endothelial cell monolayers. Microvasc Res. 2010 Sep; 80(2):240-9. PMID: 20417648.
      Citations:    
    63. Holinstat M, Preininger AM, Milne SB, Hudson WJ, Brown HA, Hamm HE. Irreversible platelet activation requires protease-activated receptor 1-mediated signaling to phosphatidylinositol phosphates. Mol Pharmacol. 2009 Aug; 76(2):301-13. PMID: 19483102.
      Citations:    
    64. Voss B, McLaughlin JN, Holinstat M, Zent R, Hamm HE. PAR1, but not PAR4, activates human platelets through a Gi/o/phosphoinositide-3 kinase signaling axis. Mol Pharmacol. 2007 May; 71(5):1399-406. PMID: 17303701.
      Citations:    
    65. Holinstat M, Voss B, Bilodeau ML, Hamm HE. Protease-activated receptors differentially regulate human platelet activation through a phosphatidic acid-dependent pathway. Mol Pharmacol. 2007 Mar; 71(3):686-94. PMID: 17151288.
      Citations:    
    66. Holinstat M, Oldham WM, Hamm HE. G-protein-coupled receptors: evolving views on physiological signalling: symposium on G-protein-coupled receptors: evolving concepts and new techniques. EMBO Rep. 2006 Sep; 7(9):866-9. PMID: 16906127.
      Citations:    
    67. Holinstat M, Voss B, Bilodeau ML, McLaughlin JN, Cleator J, Hamm HE. PAR4, but not PAR1, signals human platelet aggregation via Ca2+ mobilization and synergistic P2Y12 receptor activation. J Biol Chem. 2006 Sep 8; 281(36):26665-74. PMID: 16837456.
      Citations:    
    68. Holinstat M, Knezevic N, Broman M, Samarel AM, Malik AB, Mehta D. Suppression of RhoA activity by focal adhesion kinase-induced activation of p190RhoGAP: role in regulation of endothelial permeability. J Biol Chem. 2006 Jan 27; 281(4):2296-305. PMID: 16308318.
      Citations:    
    69. McLaughlin JN, Shen L, Holinstat M, Brooks JD, Dibenedetto E, Hamm HE. Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-activated receptor-1. J Biol Chem. 2005 Jul 1; 280(26):25048-59. PMID: 15878870.
      Citations:    
    70. Park TJ, Klug A, Holinstat M, Grothe B. Interaural level difference processing in the lateral superior olive and the inferior colliculus. J Neurophysiol. 2004 Jul; 92(1):289-301. PMID: 15056693.
      Citations:    
    71. Ahmmed GU, Mehta D, Vogel S, Holinstat M, Paria BC, Tiruppathi C, Malik AB. Protein kinase Calpha phosphorylates the TRPC1 channel and regulates store-operated Ca2+ entry in endothelial cells. J Biol Chem. 2004 May 14; 279(20):20941-9. PMID: 15016832.
      Citations:    
    72. Mehta D, Ahmmed GU, Paria BC, Holinstat M, Voyno-Yasenetskaya T, Tiruppathi C, Minshall RD, Malik AB. RhoA interaction with inositol 1,4,5-trisphosphate receptor and transient receptor potential channel-1 regulates Ca2+ entry. Role in signaling increased endothelial permeability. J Biol Chem. 2003 Aug 29; 278(35):33492-500. PMID: 12766172.
      Citations:    
    73. Holinstat M, Mehta D, Kozasa T, Minshall RD, Malik AB. Protein kinase Calpha-induced p115RhoGEF phosphorylation signals endothelial cytoskeletal rearrangement. J Biol Chem. 2003 Aug 1; 278(31):28793-8. PMID: 12754211.
      Citations:    
    74. Mehta D, Tiruppathi C, Sandoval R, Minshall RD, Holinstat M, Malik AB. Modulatory role of focal adhesion kinase in regulating human pulmonary arterial endothelial barrier function. J Physiol. 2002 Mar 15; 539(Pt 3):779-89. PMID: 11897849.
      Citations:    
    Holinstat's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (178)
    Explore
    _
    Co-Authors (6)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _
    Physical Neighbors
    _