Thomas Jefferson University

Mark Fortini

TitleAssoc Prof CHP
InstitutionThomas Jefferson University
DepartmentNursing - Undergraduate
Address233 S. 10th Street
Philadelphia PA 19107
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    Collapse Research 
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    Z01BC010529     (FORTINI, MARK E)
    NIH
    Regulated proteolysis in developmental signaling
    Role: Principal Investigator
    Z01BC010912     (FORTINI, MARK E)
    NIH
    Novel role of an aquaporin in endosome biogenesis and Notch signaling
    Role: Principal Investigator
    Z01BC010913     (FORTINI, MARK E)
    NIH
    Identification and characterization of new mutants affecting Notch trafficking
    Role: Principal Investigator
    ZIABC010912     (FORTINI, MARK E)
    NIH
    Novel role of an aquaporin in endosome biogenesis and Notch signaling
    Role: Principal Investigator
    ZIABC010913     (FORTINI, MARK E)
    NIH
    Identification and characterization of new mutants affecting Notch trafficking
    Role: Principal Investigator
    R01AG014583     (BONINI, NANCY M)May 1, 1997 - Apr 30, 2005
    NIH
    ACTIVITY OF THE ALZHEIMERS DISEASE PRESENIL IN PROTEIN
    Role: Co-Principal Investigator
    R03TW001336     (FORTINI, MARK E)Jun 1, 2000 - May 31, 2003
    NIH
    ALZHEIMER'S DISEASE RELATED PRESENILINS
    Role: Principal Investigator
    R01GM087650     (FORTINI, MARK E)May 1, 2009 - Apr 30, 2014
    NIH
    Trafficking and Proteolysis of Notch and Other Gamma-Secretase Substrates
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Khanna MR, Fortini ME. Transcriptomic Analysis of Drosophila Mushroom Body Neurons Lacking Amyloid-ß Precursor-Like Protein Activity. J Alzheimers Dis. 2015 Jun 26; 46(4):913-28. PMID: 26402626.
      Citations:    
    2. Sasamura T, Matsuno K, Fortini ME. Disruption of Drosophila melanogaster Lipid Metabolism Genes Causes Tissue Overgrowth Associated with Altered Developmental Signaling. PLoS Genet. 2013 Nov; 9(11):e1003917. PMID: 24244188.
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    3. Groth C, Sasamura T, Khanna MR, Whitley M, Fortini ME. Protein trafficking abnormalities in Drosophila tissues with impaired activity of the ZIP7 zinc transporter Catsup. Development. 2013 Jul; 140(14):3018-27. PMID: 23785054.
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    4. Yousefian J, Troost T, Grawe F, Sasamura T, Fortini M, Klein T. Dmon1 controls recruitment of Rab7 to maturing endosomes in Drosophila. J Cell Sci. 2013 Apr 1; 126(Pt 7):1583-94. PMID: 23418349.
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    5. Fortini ME. Introduction--Notch in development and disease. Semin Cell Dev Biol. 2012 Jun; 23(4):419-20. PMID: 22425963.
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    6. Groth C, Fortini ME. Therapeutic approaches to modulating Notch signaling: current challenges and future prospects. Semin Cell Dev Biol. 2012 Jun; 23(4):465-72. PMID: 22309842.
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    7. Yamakawa T, Yamada K, Sasamura T, Nakazawa N, Kanai M, Suzuki E, Fortini ME, Matsuno K. Deficient Notch signaling associated with neurogenic pecanex is compensated for by the unfolded protein response in Drosophila. Development. 2012 Feb; 139(3):558-67. PMID: 22190636.
      Citations:    
    8. McBride SM, Choi CH, Schoenfeld BP, Bell AJ, Liebelt DA, Ferreiro D, Choi RJ, Hinchey P, Kollaros M, Terlizzi AM, Ferrick NJ, Koenigsberg E, Rudominer RL, Sumida A, Chiorean S, Siwicki KK, Nguyen HT, Fortini ME, McDonald TV, Jongens TA. Pharmacological and genetic reversal of age-dependent cognitive deficits attributable to decreased presenilin function. J Neurosci. 2010 Jul 14; 30(28):9510-22. PMID: 20631179.
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    9. Stempfle D, Kanwar R, Loewer A, Fortini ME, Merdes G. In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity. Mol Cell Biol. 2010 Jul; 30(13):3165-75. PMID: 20421416.
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    10. Groth C, Alvord WG, Quiñones OA, Fortini ME. Pharmacological analysis of Drosophila melanogaster gamma-secretase with respect to differential proteolysis of Notch and APP. Mol Pharmacol. 2010 Apr; 77(4):567-74. PMID: 20064975.
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    11. Cuc HT, Seo JB, Choi JK, Kim WT, Park SJ, Lee DW, Kim YS, Fortini ME, Koh YH. Generation and characterization of monoclonal antibodies specific to Drosophila presenilin. Hybridoma (Larchmt). 2009 Jun; 28(3):215-20. PMID: 19519249.
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    12. Fortini ME, Bilder D. Endocytic regulation of Notch signaling. Curr Opin Genet Dev. 2009 Aug; 19(4):323-8. PMID: 19447603.
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    13. Fortini ME. Notch signaling: the core pathway and its posttranslational regulation. Dev Cell. 2009 May; 16(5):633-47. PMID: 19460341.
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    14. Diwan BA, Timofeeva O, Rice JM, Yang Y, Sharma N, Fortini ME, Wang H, Perantoni AO. Inheritance of susceptibility to induction of nephroblastomas in the Noble rat. Differentiation. 2009 Apr; 77(4):424-32. PMID: 19281789.
      Citations:    
    15. Kanwar R, Fortini ME. The big brain aquaporin is required for endosome maturation and notch receptor trafficking. Cell. 2008 May 30; 133(5):852-63. PMID: 18510929.
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    16. Vaccari T, Lu H, Kanwar R, Fortini ME, Bilder D. Endosomal entry regulates Notch receptor activation in Drosophila melanogaster. J Cell Biol. 2008 Feb 25; 180(4):755-62. PMID: 18299346.
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    17. Lu Y, Lv Y, Ye Y, Wang Y, Hong Y, Fortini ME, Zhong Y, Xie Z. A role for presenilin in post-stress regulation: effects of presenilin mutations on Ca2+ currents in Drosophila. FASEB J. 2007 Aug; 21(10):2368-78. PMID: 17428965.
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    18. Fortini ME. Medicine. Anticipating trouble from gene transcription. Science. 2007 Mar 30; 315(5820):1800-1. PMID: 17395816.
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    19. Dotti CG, Feiguin F, Fortini ME. gamma-cleavage-independent functions of presenilin, nicastrin, and Aph-1 regulate cell-junction organization and prevent tau toxicity in vivo. Neuron. 2007 Feb 1; 53(3):463. PMID: 17326324.
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    20. Tountas NA, Fortini ME. Drosophila as a model for human diseases: IRB and ICREA, Barcelona, Spain, October 5-7, 2006. Fly (Austin). 2007 Jan-Feb; 1(1):47-54. PMID: 18690062.
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    21. Seidner GA, Ye Y, Faraday MM, Alvord WG, Fortini ME. Modeling clinically heterogeneous presenilin mutations with transgenic Drosophila. Curr Biol. 2006 May 23; 16(10):1026-33. PMID: 16713961.
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    22. Doglio LE, Kanwar R, Jackson GR, Perez M, Avila J, Dingwall C, Dotti CG, Fortini ME, Feiguin F. gamma-cleavage-independent functions of presenilin, nicastrin, and Aph-1 regulate cell-junction organization and prevent tau toxicity in vivo. Neuron. 2006 May 4; 50(3):359-75. PMID: 16675392.
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    23. Kanwar R, Fortini ME. Notch signaling: a different sort makes the cut. Curr Biol. 2004 Dec 29; 14(24):R1043-5. PMID: 15620635.
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    24. Periz G, Fortini ME. Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2. J Neurosci Res. 2004 Aug 1; 77(3):309-22. PMID: 15248287.
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    25. Fortini ME. PAR-1 for the course of neurodegeneration. Cell. 2004 Mar 5; 116(5):631-2. PMID: 15006343.
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    26. Fortini ME. Neurobiology: double trouble for neurons. Nature. 2003 Oct 9; 425(6958):565-6. PMID: 14534567.
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    27. Hu Y, Fortini ME. Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex. J Cell Biol. 2003 May 26; 161(4):685-90. PMID: 12771124.
      Citations:    
    28. Bonini NM, Fortini ME. Human neurodegenerative disease modeling using Drosophila. Annu Rev Neurosci. 2003; 26:627-56. PMID: 12704223.
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    29. Fortini ME. Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling. Nat Rev Mol Cell Biol. 2002 Sep; 3(9):673-84. PMID: 12209127.
      Citations:    
    30. Hu Y, Ye Y, Fortini ME. Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor. Dev Cell. 2002 Jan; 2(1):69-78. PMID: 11782315.
      Citations:    
    31. Bonini NM, Fortini ME. Applications of the Drosophila retina to human disease modeling. Results Probl Cell Differ. 2002; 37:257-75. PMID: 25707079.
      Citations:    
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