Keywords
Last Name
Institution

Mark Fortini

TitleAssoc Professor
InstitutionThomas Jefferson University
DepartmentBiochem & Molecular Biology
Address233 S. 10th Street
Philadelphia PA 19107
vCardDownload vCard

    Collapse Research 
    Collapse research activities and funding
    Z01BC010529     (FORTINI, MARK E)
    NIH/NCI
    Regulated proteolysis in developmental signaling
    Role: Principal Investigator

    Z01BC010912     (FORTINI, MARK E)
    NIH/NCI
    Novel role of an aquaporin in endosome biogenesis and Notch signaling
    Role: Principal Investigator

    Z01BC010913     (FORTINI, MARK E)
    NIH/NCI
    Identification and characterization of new mutants affecting Notch trafficking
    Role: Principal Investigator

    ZIABC010912     (FORTINI, MARK E)
    NIH/NCI
    Novel role of an aquaporin in endosome biogenesis and Notch signaling
    Role: Principal Investigator

    ZIABC010913     (FORTINI, MARK E)
    NIH/NCI
    Identification and characterization of new mutants affecting Notch trafficking
    Role: Principal Investigator

    R01AG014583     (BONINI, NANCY M)May 1, 1997 - Apr 30, 2005
    NIH/NIA
    ACTIVITY OF THE ALZHEIMERS DISEASE PRESENIL IN PROTEIN
    Role: Co-Principal Investigator

    R03TW001336     (FORTINI, MARK E)Jun 1, 2000 - May 31, 2003
    NIH/FIC
    ALZHEIMER'S DISEASE RELATED PRESENILINS
    Role: Principal Investigator

    R01GM087650     (FORTINI, MARK E)May 1, 2009 - Apr 30, 2014
    NIH/NIGMS
    Trafficking and Proteolysis of Notch and Other Gamma-Secretase Substrates
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Khanna MR, Fortini ME. Transcriptomic Analysis of Drosophila Mushroom Body Neurons Lacking Amyloid-ß Precursor-Like Protein Activity. J Alzheimers Dis. 2015 Jun 26; 46(4):913-28. PMID: 26402626.
      View in: PubMed
    2. Sasamura T, Matsuno K, Fortini ME. Disruption of Drosophila melanogaster Lipid Metabolism Genes Causes Tissue Overgrowth Associated with Altered Developmental Signaling. PLoS Genet. 2013 Nov; 9(11):e1003917. PMID: 24244188.
      View in: PubMed
    3. Groth C, Sasamura T, Khanna MR, Whitley M, Fortini ME. Protein trafficking abnormalities in Drosophila tissues with impaired activity of the ZIP7 zinc transporter Catsup. Development. 2013 Jul; 140(14):3018-27. PMID: 23785054.
      View in: PubMed
    4. Yousefian J, Troost T, Grawe F, Sasamura T, Fortini M, Klein T. Dmon1 controls recruitment of Rab7 to maturing endosomes in Drosophila. J Cell Sci. 2013 Apr 1; 126(Pt 7):1583-94. PMID: 23418349.
      View in: PubMed
    5. Fortini ME. Introduction--Notch in development and disease. Semin Cell Dev Biol. 2012 Jun; 23(4):419-20. PMID: 22425963.
      View in: PubMed
    6. Groth C, Fortini ME. Therapeutic approaches to modulating Notch signaling: current challenges and future prospects. Semin Cell Dev Biol. 2012 Jun; 23(4):465-72. PMID: 22309842.
      View in: PubMed
    7. Yamakawa T, Yamada K, Sasamura T, Nakazawa N, Kanai M, Suzuki E, Fortini ME, Matsuno K. Deficient Notch signaling associated with neurogenic pecanex is compensated for by the unfolded protein response in Drosophila. Development. 2012 Feb; 139(3):558-67. PMID: 22190636.
      View in: PubMed
    8. McBride SM, Choi CH, Schoenfeld BP, Bell AJ, Liebelt DA, Ferreiro D, Choi RJ, Hinchey P, Kollaros M, Terlizzi AM, Ferrick NJ, Koenigsberg E, Rudominer RL, Sumida A, Chiorean S, Siwicki KK, Nguyen HT, Fortini ME, McDonald TV, Jongens TA. Pharmacological and genetic reversal of age-dependent cognitive deficits attributable to decreased presenilin function. J Neurosci. 2010 Jul 14; 30(28):9510-22. PMID: 20631179.
      View in: PubMed
    9. Stempfle D, Kanwar R, Loewer A, Fortini ME, Merdes G. In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity. Mol Cell Biol. 2010 Jul; 30(13):3165-75. PMID: 20421416.
      View in: PubMed
    10. Groth C, Alvord WG, Quiñones OA, Fortini ME. Pharmacological analysis of Drosophila melanogaster gamma-secretase with respect to differential proteolysis of Notch and APP. Mol Pharmacol. 2010 Apr; 77(4):567-74. PMID: 20064975.
      View in: PubMed
    11. Cuc HT, Seo JB, Choi JK, Kim WT, Park SJ, Lee DW, Kim YS, Fortini ME, Koh YH. Generation and characterization of monoclonal antibodies specific to Drosophila presenilin. Hybridoma (Larchmt). 2009 Jun; 28(3):215-20. PMID: 19519249.
      View in: PubMed
    12. Fortini ME, Bilder D. Endocytic regulation of Notch signaling. Curr Opin Genet Dev. 2009 Aug; 19(4):323-8. PMID: 19447603.
      View in: PubMed
    13. Fortini ME. Notch signaling: the core pathway and its posttranslational regulation. Dev Cell. 2009 May; 16(5):633-47. PMID: 19460341.
      View in: PubMed
    14. Diwan BA, Timofeeva O, Rice JM, Yang Y, Sharma N, Fortini ME, Wang H, Perantoni AO. Inheritance of susceptibility to induction of nephroblastomas in the Noble rat. Differentiation. 2009 Apr; 77(4):424-32. PMID: 19281789.
      View in: PubMed
    15. Kanwar R, Fortini ME. The big brain aquaporin is required for endosome maturation and notch receptor trafficking. Cell. 2008 May 30; 133(5):852-63. PMID: 18510929.
      View in: PubMed
    16. Vaccari T, Lu H, Kanwar R, Fortini ME, Bilder D. Endosomal entry regulates Notch receptor activation in Drosophila melanogaster. J Cell Biol. 2008 Feb 25; 180(4):755-62. PMID: 18299346.
      View in: PubMed
    17. Lu Y, Lv Y, Ye Y, Wang Y, Hong Y, Fortini ME, Zhong Y, Xie Z. A role for presenilin in post-stress regulation: effects of presenilin mutations on Ca2+ currents in Drosophila. FASEB J. 2007 Aug; 21(10):2368-78. PMID: 17428965.
      View in: PubMed
    18. Fortini ME. Medicine. Anticipating trouble from gene transcription. Science. 2007 Mar 30; 315(5820):1800-1. PMID: 17395816.
      View in: PubMed
    19. Dotti CG, Feiguin F, Fortini ME. gamma-cleavage-independent functions of presenilin, nicastrin, and Aph-1 regulate cell-junction organization and prevent tau toxicity in vivo. Neuron. 2007 Feb 1; 53(3):463. PMID: 17326324.
      View in: PubMed
    20. Tountas NA, Fortini ME. Drosophila as a model for human diseases: IRB and ICREA, Barcelona, Spain, October 5-7, 2006. Fly (Austin). 2007 Jan-Feb; 1(1):47-54. PMID: 18690062.
      View in: PubMed
    21. Seidner GA, Ye Y, Faraday MM, Alvord WG, Fortini ME. Modeling clinically heterogeneous presenilin mutations with transgenic Drosophila. Curr Biol. 2006 May 23; 16(10):1026-33. PMID: 16713961.
      View in: PubMed
    22. Doglio LE, Kanwar R, Jackson GR, Perez M, Avila J, Dingwall C, Dotti CG, Fortini ME, Feiguin F. gamma-cleavage-independent functions of presenilin, nicastrin, and Aph-1 regulate cell-junction organization and prevent tau toxicity in vivo. Neuron. 2006 May 4; 50(3):359-75. PMID: 16675392.
      View in: PubMed
    23. Kanwar R, Fortini ME. Notch signaling: a different sort makes the cut. Curr Biol. 2004 Dec 29; 14(24):R1043-5. PMID: 15620635.
      View in: PubMed
    24. Periz G, Fortini ME. Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2. J Neurosci Res. 2004 Aug 1; 77(3):309-22. PMID: 15248287.
      View in: PubMed
    25. Fortini ME. PAR-1 for the course of neurodegeneration. Cell. 2004 Mar 5; 116(5):631-2. PMID: 15006343.
      View in: PubMed
    26. Fortini ME. Neurobiology: double trouble for neurons. Nature. 2003 Oct 9; 425(6958):565-6. PMID: 14534567.
      View in: PubMed
    27. Hu Y, Fortini ME. Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex. J Cell Biol. 2003 May 26; 161(4):685-90. PMID: 12771124.
      View in: PubMed
    28. Bonini NM, Fortini ME. Human neurodegenerative disease modeling using Drosophila. Annu Rev Neurosci. 2003; 26:627-56. PMID: 12704223.
      View in: PubMed
    29. Fortini ME. Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling. Nat Rev Mol Cell Biol. 2002 Sep; 3(9):673-84. PMID: 12209127.
      View in: PubMed
    30. Hu Y, Ye Y, Fortini ME. Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor. Dev Cell. 2002 Jan; 2(1):69-78. PMID: 11782315.
      View in: PubMed
    31. Bonini NM, Fortini ME. Applications of the Drosophila retina to human disease modeling. Results Probl Cell Differ. 2002; 37:257-75. PMID: 25707079.
      View in: PubMed
    Fortini's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description
    Physical Neighbors Expand Description
    _