Michael Root

TitleAssoc Professor
InstitutionThomas Jefferson University
DepartmentBiochem & Molecular Biology
Address233 S. 10th Street
Philadelphia PA 19107
vCardDownload vCard

    Collapse Research 
    Collapse research activities and funding
    R01AI150490     (ROOT, MICHAEL JEFFREY)Sep 1, 2002 - Apr 30, 2021
    NIH
    Mechanisms of HIV-1 Env-Mediated Membrane Fusion
    Role: Principal Investigator

    R01GM066682     (ROOT, MICHAEL JEFFREY)Sep 1, 2002 - Apr 30, 2021
    NIH
    Mechanisms of HIV-1 Env-Mediated Membrane Fusion
    Role: Principal Investigator

    R21AI059188     (ROOT, MICHAEL JEFFREY)Sep 30, 2004 - Aug 31, 2007
    NIH
    Structure of SARS Coronavirus Spike Glycoprotein
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Smith AR, Weinstock MT, Siglin AE, Whitby FG, Francis JN, Hill CP, Eckert DM, Root MJ, Kay MS. Characterization of resistance to a potent D-peptide HIV entry inhibitor. Retrovirology. 2019 10 22; 16(1):28. PMID: 31640718.
      Citations:    
    2. Ahn KW, Root MJ. Complex interplay of kinetic factors governs the synergistic properties of HIV-1 entry inhibitors. J Biol Chem. 2017 Jul 10. PMID: 28696261.
      Citations:    
    3. Khasnis MD, Halkidis K, Bhardwaj A, Root MJ. Receptor Activation of HIV-1 Env Leads to Asymmetric Exposure of the gp41 Trimer. PLoS Pathog. 2016 Dec; 12(12):e1006098. PMID: 27992602.
      Citations:    
    4. Leslie GJ, Wang J, Richardson MW, Haggarty BS, Hua KL, Duong J, Secreto AJ, Jordon AP, Romano J, Kumar KE, DeClercq JJ, Gregory PD, June CH, Root MJ, Riley JL, Holmes MC, Hoxie JA. Potent and Broad Inhibition of HIV-1 by a Peptide from the gp41 Heptad Repeat-2 Domain Conjugated to the CXCR4 Amino Terminus. PLoS Pathog. 2016 Nov; 12(11):e1005983. PMID: 27855210.
      Citations:    
    5. Danial M, Stauffer A, Wurm FR, Root MJ, Klok HA. Site-specific Polymer Attachment to HR2 Peptide Fusion Inhibitors against HIV-1 Decreases Binding Association Rates and Dissociation Rates rather than Binding Affinity. Bioconjug Chem. 2016 Oct 13. PMID: 27737540.
      Citations:    
    6. Patton J, Vuyyuru R, Siglin A, Root M, Manser T. Evaluation of the efficiency of human immune system reconstitution in NSG mice and NSG mice containing a human HLA.A2 transgene using hematopoietic stem cells purified from different sources. J Immunol Methods. 2015 Jul; 422:13-21. PMID: 25776756.
      Citations:    
    7. Rosemary Bastian A, Nangarlia A, Bailey LD, Holmes A, Kalyana Sundaram RV, Ang C, Moreira DR, Freedman K, Duffy C, Contarino M, Abrams C, Root M, Chaiken I. Mechanism of Multivalent Nanoparticle Encounter with HIV-1 for Potency Enhancement of Peptide Triazole Virus Inactivation. J Biol Chem. 2015 Jan 2; 290(1):529-43. PMID: 25371202.
      Citations:    
    8. Danial M, Root MJ, Klok HA. Polyvalent side chain peptide-synthetic polymer conjugates as HIV-1 entry inhibitors. Biomacromolecules. 2012 May 14; 13(5):1438-47. PMID: 22455441.
      Citations:    
    9. Pumroy RA, Nardozzi JD, Hart DJ, Root MJ, Cingolani G. Nucleoporin Nup50 stabilizes closed conformation of armadillo repeat 10 in importin a5. J Biol Chem. 2012 Jan 13; 287(3):2022-31. PMID: 22130666.
      Citations:    
    10. Welch BD, Francis JN, Redman JS, Paul S, Weinstock MT, Reeves JD, Lie YS, Whitby FG, Eckert DM, Hill CP, Root MJ, Kay MS. Design of a potent D-peptide HIV-1 entry inhibitor with a strong barrier to resistance. J Virol. 2010 Nov; 84(21):11235-44. PMID: 20719956.
      Citations:    
    11. Kahle KM, Steger HK, Root MJ. Asymmetric deactivation of HIV-1 gp41 following fusion inhibitor binding. PLoS Pathog. 2009 Nov; 5(11):e1000674. PMID: 19956769.
      Citations:    
    12. Lederman MM, Jump R, Pilch-Cooper HA, Root M, Sieg SF. Topical application of entry inhibitors as "virustats" to prevent sexual transmission of HIV infection. Retrovirology. 2008; 5:116. PMID: 19094217.
      Citations:    
    13. Champagne K, Shishido A, Root MJ. Interactions of HIV-1 inhibitory peptide T20 with the gp41 N-HR coiled coil. J Biol Chem. 2009 Feb 6; 284(6):3619-27. PMID: 19073602.
      Citations:    
    14. Root MJ. Implantable cardiac rhythm device batteries. J Cardiovasc Transl Res. 2008 Dec; 1(4):254-7. PMID: 20559932.
      Citations:    
    15. Adekar SP, Takahashi T, Jones RM, Al-Saleem FH, Ancharski DM, Root MJ, Kapadnis BP, Simpson LL, Dessain SK. Neutralization of botulinum neurotoxin by a human monoclonal antibody specific for the catalytic light chain. PLoS One. 2008; 3(8):e3023. PMID: 18714390.
      Citations:    
    16. Adekar SP, Jones RM, Elias MD, Al-Saleem FH, Root MJ, Simpson LL, Dessain SK. Hybridoma populations enriched for affinity-matured human IgGs yield high-affinity antibodies specific for botulinum neurotoxins. J Immunol Methods. 2008 Apr 20; 333(1-2):156-66. PMID: 18313069.
      Citations:    
    17. Adekar SP, Jones RM, Elias MD, Al-Saleem FH, Root MJ, Simpson LL, Dessain SK. A human monoclonal antibody that binds serotype A botulinum neurotoxin. Hybridoma (Larchmt). 2008 Feb; 27(1):11-7. PMID: 18294071.
      Citations:    
    18. Sugaya M, Hartley O, Root MJ, Blauvelt A. C34, a membrane fusion inhibitor, blocks HIV infection of langerhans cells and viral transmission to T cells. J Invest Dermatol. 2007 Jun; 127(6):1436-43. PMID: 17255952.
      Citations:    
    19. Steger HK, Root MJ. Kinetic dependence to HIV-1 entry inhibition. J Biol Chem. 2006 Sep 1; 281(35):25813-21. PMID: 16803885.
      Citations:    
    20. Root MJ, Steger HK. HIV-1 gp41 as a target for viral entry inhibition. Curr Pharm Des. 2004; 10(15):1805-25. PMID: 15180542.
      Citations:    
    21. Root MJ, Hamer DH. Targeting therapeutics to an exposed and conserved binding element of the HIV-1 fusion protein. Proc Natl Acad Sci U S A. 2003 Apr 29; 100(9):5016-21. PMID: 12702763.
      Citations:    
    22. Root AW, Root MJ. Clinical pharmacology of human growth hormone and its secretagogues. Curr Drug Targets Immune Endocr Metabol Disord. 2002 Apr; 2(1):27-52. PMID: 12477295.
      Citations:    
    Root's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (100)
    Explore
    _
    Co-Authors (4)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _
    Physical Neighbors
    _