Thomas Jefferson University

Marion Siegman

TitleFaculty
InstitutionThomas Jefferson University
DepartmentPhysiology - Thomas Jefferson University
Address1015 Walnut Street
Philadelphia PA 19107
Phone215-503-3975
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    Collapse Overview 
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    Electron Microscopy
    Muscle Mechanical Properties


    Collapse Research 
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    R13HL035834     (SIEGMAN, MARION J)May 1, 1986 - Apr 30, 1987
    NIH
    CONFERENCE ON CONTRACTION OF SMOOTH MUSCLE
    Role: Principal Investigator
    R01DK037598     (SIEGMAN, MARION J)Apr 1, 1988 - Mar 31, 1994
    NIH
    FUNCTIONAL ADAPTATIONS OF INTESTINAL SMOOTH MUSCLE
    Role: Principal Investigator
    R01AR042758     (BUTLER, THOMAS M)Dec 1, 1994 - Jul 31, 2010
    NIH
    CATCH: Mechanochemistry and Regulation in Smooth muscle
    Role: Co-Principal Investigator
    R01DK091432     (SIEGMAN, MARION JOYCE)Sep 12, 2011 - Aug 31, 2015
    NIH
    Dynamic limits on contraction of gastrointestinal smooth muscle
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Osher RH, Miller VJ, Eagle RC, Siegman MJ, Wang D, Osborn DA. Polychromasia capsulare: Determining the cause of multicolored iridescence of the anterior lens capsule. J Cataract Refract Surg. 2016 04; 42(4):631-4. PMID: 27113889.
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    2. Siegman MJ, Eto M, Butler TM. Remodeling of the rat distal colon in diabetes: function and ultrastructure. Am J Physiol Cell Physiol. 2016 Jan 15; 310(2):C151-60. PMID: 26561639.
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    3. Siegman MJ. The pathway for force transmission in the rat anococcygeus muscle: a tale of two tendons. Anat Rec (Hoboken). 2014 Sep; 297(9):1714-33. PMID: 25125184.
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    4. Siegman MJ, Davidheiser S, Mooers SU, Butler TM. Structural limits on force production and shortening of smooth muscle. J Muscle Res Cell Motil. 2013 Feb; 34(1):43-60. PMID: 23233203.
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    5. Butler TM, Siegman MJ. A force-activated kinase in a catch smooth muscle. J Muscle Res Cell Motil. 2011 Mar; 31(5-6):349-58. PMID: 21286791.
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    6. Butler TM, Mooers SU, Narayan SR, Siegman MJ. The N-terminal region of twitchin binds thick and thin contractile filaments: redundant mechanisms of catch force maintenance. J Biol Chem. 2010 Dec 24; 285(52):40654-65. PMID: 20971853.
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    7. Butler TM, Siegman MJ. Mechanism of catch force: tethering of thick and thin filaments by twitchin. J Biomed Biotechnol. 2010; 2010:725207. PMID: 20625409.
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    8. Franke AS, Mooers SU, Narayan SR, Siegman MJ, Butler TM. Myosin cross-bridge kinetics and the mechanism of catch. Biophys J. 2007 Jul 15; 93(2):554-65. PMID: 17468160.
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    9. Butler TM, Mooers SU, Siegman MJ. Catch force links and the low to high force transition of myosin. Biophys J. 2006 May 01; 90(9):3193-202. PMID: 16473905.
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    10. Funabara D, Kanoh S, Siegman MJ, Butler TM, Hartshorne DJ, Watabe S. Twitchin as a regulator of catch contraction in molluscan smooth muscle. J Muscle Res Cell Motil. 2005; 26(6-8):455-60. PMID: 16453161.
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    11. Siegman MJ, Hartshorne DJ. Obituary. Andrew P. Somlyo (1930-2004). J Muscle Res Cell Motil. 2004; 25(3):193-202. PMID: 15505897.
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    12. Funabara D, Watabe S, Mooers SU, Narayan S, Dudas C, Hartshorne DJ, Siegman MJ, Butler TM. Twitchin from molluscan catch muscle: primary structure and relationship between site-specific phosphorylation and mechanical function. J Biol Chem. 2003 Aug 01; 278(31):29308-16. PMID: 12756258.
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    13. Funabara D, Kinoshita S, Watabe S, Siegman MJ, Butler TM, Hartshorne DJ. Phosphorylation of molluscan twitchin by the cAMP-dependent protein kinase. Biochemistry. 2001 Feb 20; 40(7):2087-95. PMID: 11329277.
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    14. Butler TM, Narayan SR, Mooers SU, Hartshorne DJ, Siegman MJ. The myosin cross-bridge cycle and its control by twitchin phosphorylation in catch muscle. Biophys J. 2001 Jan; 80(1):415-26. PMID: 11159412.
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    15. Butler TM, Siegman MJ. Control of cross-bridge cycling by myosin light chain phosphorylation in mammalian smooth muscle. Acta Physiol Scand. 1998 Dec; 164(4):389-400. PMID: 9887963.
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    16. Butler TM, Mooers SU, Li C, Narayan S, Siegman MJ. Regulation of catch muscle by twitchin phosphorylation: effects on force, ATPase, and shortening. Biophys J. 1998 Oct; 75(4):1904-14. PMID: 9746531.
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    17. Siegman MJ, Funabara D, Kinoshita S, Watabe S, Hartshorne DJ, Butler TM. Phosphorylation of a twitchin-related protein controls catch and calcium sensitivity of force production in invertebrate smooth muscle. Proc Natl Acad Sci U S A. 1998 Apr 28; 95(9):5383-8. PMID: 9560285.
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    18. Siegman MJ, Mooers SU, Li C, Narayan S, Trinkle-Mulcahy L, Watabe S, Hartshorne DJ, Butler TM. Phosphorylation of a high molecular weight (approximately 600 kDa) protein regulates catch in invertebrate smooth muscle. J Muscle Res Cell Motil. 1997 Dec; 18(6):655-70. PMID: 9429159.
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    19. Siegman MJ, Butler TM, Mooers SU, Trinkle-Mulcahy L, Narayan S, Stirewalt WS, Starcher BC. Hypertrophy of colonic smooth muscle: structural remodeling, chemical composition, and force output. Am J Physiol. 1997 Jun; 272(6 Pt 1):G1560-70. PMID: 9227494.
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    20. Siegman MJ, Butler TM, Mooers SU, Trinkle-Mulcahy L, Narayan S, Adam L, Chacko S, Haase H, Morano I. Hypertrophy of colonic smooth muscle: contractile proteins, shortening velocity, and regulation. Am J Physiol. 1997 Jun; 272(6 Pt 1):G1571-80. PMID: 9227495.
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    21. Trinkle-Mulcahy L, Ichikawa K, Hartshorne DJ, Siegman MJ, Butler TM. Thiophosphorylation of the 130-kDa subunit is associated with a decreased activity of myosin light chain phosphatase in alpha-toxin-permeabilized smooth muscle. J Biol Chem. 1995 Aug 04; 270(31):18191-4. PMID: 7629133.
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    22. Butler TM, Narayan SR, Mooers SU, Siegman MJ. Rapid turnover of myosin light chain phosphate during cross-bridge cycling in smooth muscle. Am J Physiol. 1994 Oct; 267(4 Pt 1):C1160-6. PMID: 7943280.
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    23. Siegman MJ, Mooers SU, Warren TB, Warshaw DM, Ikebe M, Butler TM. Comparison of the effects of 2,3-butanedione monoxime on force production, myosin light chain phosphorylation and chemical energy usage in intact and permeabilized smooth and skeletal muscles. J Muscle Res Cell Motil. 1994 Aug; 15(4):457-72. PMID: 7806639.
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    24. Trinkle-Mulcahy L, Siegman MJ, Butler TM. Metabolic characteristics of alpha-toxin-permeabilized smooth muscle. Am J Physiol. 1994 Jun; 266(6 Pt 1):C1673-83. PMID: 8023897.
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    25. Vyas TB, Mooers SU, Narayan SR, Siegman MJ, Butler TM. Cross-bridge cycling at rest and during activation. Turnover of myosin-bound ADP in permeabilized smooth muscle. J Biol Chem. 1994 Mar 11; 269(10):7316-22. PMID: 8125947.
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    26. Liddell RA, Mooers SU, Siegman MJ, McHugh KM. Altered isoactin gene expression in the affected bowel segments of the lethal spotted mouse. Gastroenterology. 1993 Aug; 105(2):441-8. PMID: 8335200.
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    27. Vyas TB, Mooers SU, Narayan SR, Witherell JC, Siegman MJ, Butler TM. Cooperative activation of myosin by light chain phosphorylation in permeabilized smooth muscle. Am J Physiol. 1992 Jul; 263(1 Pt 1):C210-9. PMID: 1386187.
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    28. Siegman MJ, Vyas TB, Mooers SU, Butler TM. Energetics and regulation of smooth muscle contraction. Jpn J Pharmacol. 1992; 58 Suppl 2:75P-80P. PMID: 1507647.
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    29. Siegman MJ, Butler TM, Vyas T, Mooers SU, Narayan S. Cooperative mechanisms in the regulation of smooth muscle contraction. Adv Exp Med Biol. 1991; 304:77-84. PMID: 1803924.
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    30. Butler TM, Siegman MJ, Mooers SU, Narayan SR. Myosin-product complex in the resting state and during relaxation of smooth muscle. Am J Physiol. 1990 Jun; 258(6 Pt 1):C1092-9. PMID: 2141759.
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    31. Siegman MJ, Butler TM, Mooers SU. Energetics as an approach to the study of smooth muscle: the Bozler legacy. Prog Clin Biol Res. 1990; 327:17-27. PMID: 2181460.
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    32. Siegman MJ, Butler TM, Mooers SU. Phosphatase inhibition with okadaic acid does not alter the relationship between force and myosin light chain phosphorylation in permeabilized smooth muscle. Biochem Biophys Res Commun. 1989 Jun 15; 161(2):838-42. PMID: 2544178.
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    33. Osborne JA, Siegman MJ, Sedar AW, Mooers SU, Lefer AM. Lack of endothelium-dependent relaxation in coronary resistance arteries of cholesterol-fed rabbits. Am J Physiol. 1989 Mar; 256(3 Pt 1):C591-7. PMID: 2923194.
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    34. Butler TM, Pacifico DS, Siegman MJ, Mooers SU. ADP release from permeabilized smooth muscle under resting and activated conditions. Prog Clin Biol Res. 1989; 315:359-71. PMID: 2798500.
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    35. Butler TM, Pacifico DS, Siegman MJ. ADP release from myosin in permeabilized smooth muscle. Am J Physiol. 1989 Jan; 256(1 Pt 1):C59-66. PMID: 2492153.
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    36. Siegman MJ, Butler TM, Mooers SU. Effects of okadaic acid on the relationships among force, myosin light chain phosphorylation and ATPase activity in skinned portal vein. Prog Clin Biol Res. 1989; 315:305-16. PMID: 2529565.
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    37. Butler TM, Siegman MJ, Mooers SU. Slowing of crossbridge cycling rate in mammalian smooth muscle occurs without evidence of an increase in internal load. Prog Clin Biol Res. 1987; 245:289-301. PMID: 3685015.
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    38. Butler TM, Siegman MJ, Mooers SU. Slowing of cross-bridge cycling in smooth muscle without evidence of an internal load. Am J Physiol. 1986 Dec; 251(6 Pt 1):C945-50. PMID: 3789134.
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    39. Siegman MJ, Butler TM, Mooers SU. Energetics and regulation of crossbridge states in mammalian smooth muscle. Experientia. 1985 Aug 15; 41(8):1020-5. PMID: 3160604.
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    40. Butler TM, Siegman MJ. High-energy phosphate metabolism in vascular smooth muscle. Annu Rev Physiol. 1985; 47:629-43. PMID: 3158271.
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    41. Siegman MJ, Butler TM, Mooers SU, Michalek A. Ca2+ can affect Vmax without changes in myosin light chain phosphorylation in smooth muscle. Pflugers Arch. 1984 Aug; 401(4):385-90. PMID: 6483580.
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    42. Butler TM, Siegman MJ, Mooers SU. Chemical energy usage during stimulation and stretch of mammalian smooth muscle. Pflugers Arch. 1984 Aug; 401(4):391-5. PMID: 6483581.
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    43. Butler TM, Siegman MJ, Mooers SU, Barsotti RJ. Myosin light chain phosphorylation does not modulate cross-bridge cycling rate in mouse skeletal muscle. Science. 1983 Jun 10; 220(4602):1167-9. PMID: 6857239.
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    44. Butler TM, Siegman MJ, Mooers SU. Chemical energy usage during shortening and work production in mammalian smooth muscle. Am J Physiol. 1983 Mar; 244(3):C234-42. PMID: 6829747.
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    45. Butler TM, Siegman MJ. Chemical energy usage and myosin light chain phosphorylation in mammalian smooth muscle. Fed Proc. 1983 Jan; 42(1):57-61. PMID: 6217085.
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    46. Butler TM, Siegman MJ. Chemical Energetics of contraction in mammalian smooth muscle. Fed Proc. 1982 Feb; 41(2):204-8. PMID: 7060747.
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    47. Butler TM, Siegman MJ, Mooers SU. Chemical energetics of contraction in mammalian smooth muscle. Soc Gen Physiol Ser. 1982; 37:189-201. PMID: 7146947.
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    48. Siegman MJ, Butler TM, Mooers SU, Davies RE. Chemical energetics of force development, force maintenance, and relaxation in mammalian smooth muscle. J Gen Physiol. 1980 Nov; 76(5):609-29. PMID: 6969290.
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    49. Butler TM, Siegman MJ, Mooers SU, Davies RE. Chemical energetics of single isometric tetani in mammalian smooth muscle. Am J Physiol. 1978 Jul; 235(1):C1-7. PMID: 677300.
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    50. Siegman MJ, Butler TM, Mooers SU, Davies RE. Calcium-dependent resistance to stretch and stress relaxation in resting smooth muscles. Am J Physiol. 1976 Nov; 231(5 Pt. 1):1501-8. PMID: 998795.
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    51. Butler TM, Siegman MJ, Davies RE. Rigor and resistance to stretch in vertebrate smooth muscle. Am J Physiol. 1976 Nov; 231(5 Pt. 1):1509-14. PMID: 998796.
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    52. Siegman MJ, Butler TM, Mooers SU, Davies RE. Crossbridge attachment, resistance to stretch, and viscoelasticity in resting mammalian smooth muscle. Science. 1976 Jan 30; 191(4225):383-5. PMID: 128819.
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    53. Siegman MJ, Gordon AR. Potentiation of contraction: effects of calcium and caffeine on active state. Am J Physiol. 1972 Jun; 222(6):1587-93. PMID: 5030216.
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    54. Gordon AR, Siegman MJ. Mechanical properties of smooth muscle. II. Active state. Am J Physiol. 1971 Nov; 221(5):1250-4. PMID: 5124268.
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    55. Gordon AR, Siegman MJ. Mechanical properties of smooth muscle. I. Length-tension and force-velocity relations. Am J Physiol. 1971 Nov; 221(5):1243-9. PMID: 5124267.
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