Thomas Jefferson University

Mark Tykocinski

TitleProfessor
InstitutionThomas Jefferson University
DepartmentJMC-Senior Administration - Thomas Jefferson University
Address1025 Walnut Street
Philadelphia PA 19107
Phone2155030417
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    R29CA047566     (TYKOCINSKI, MARK L)May 1, 1988 - Apr 30, 1993
    NIH
    HUMAN LEUKEMIC DIFFERENTIATION--ANTI-SENSE RNA STUDIES
    Role: Principal Investigator
    R01AI031044     (TYKOCINSKI, MARK L)Jul 1, 1992 - May 31, 2008
    NIH
    Engineering Artifical Veto Cells
    Role: Principal Investigator
    R01AI038960     (TYKOCINSKI, MARK L)Feb 15, 1996 - Jan 31, 2006
    NIH
    PLACENTAL PROTEIN 14 AS A UNIQUE IMMUNOREGULATOR
    Role: Principal Investigator
    R01CA069646     (TYKOCINSKI, MARK L)Sep 16, 1996 - Jun 30, 2000
    NIH
    H19 IN BLADDER CANCER
    Role: Principal Investigator
    R01CA074958     (TYKOCINSKI, MARK L)Sep 1, 1997 - Jul 31, 2008
    NIH
    CELLULAR CANCER VACCINES
    Role: Principal Investigator
    R03TW006148     (TYKOCINSKI, MARK L)Dec 15, 2002 - Nov 30, 2005
    NIH
    Placental Protein 14 as a Lectin-Like Immunomodulator
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Tykocinski ML. Academic Pathology's "Spiderless Network": The power of a professional society, its listserv, and its journal during a public health emergency. Acad Pathol. 2022; 9(1):100044. PMID: 35941877.
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    2. Mangione S, Tykocinski ML. Virchow at 200 and Lown at 100 - Physicians as Activists. N Engl J Med. 2021 Jul 22; 385(4):291-293. PMID: 34279066.
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    3. Makdasi E, Amsili S, Aronin A, Prigozhina TB, Tzdaka K, Gozlan YM, Ben Gigi-Tamir L, Sagiv JY, Shkedy F, Shani N, Tykocinski ML, Dranitzki Elhalel M. Toxicology and Pharmacokinetic Studies in Mice and Non-Human Primates of the Non-Toxic, Efficient, Targeted Hexameric FasL: CTLA4-FasL. Mol Cancer Ther. 2019 Dec 23. PMID: 31871267.
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    4. Sanfilippo F, Powell D, Folberg R, Tykocinski M. Dealing With Deans and Academic Medical Center Leadership: Advice From Leaders. Acad Pathol. 2018 Jan-Dec; 5:2374289518765462. PMID: 29662949.
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    5. Romeo C, Weber MC, Zarei M, DeCicco D, Chand SN, Lobo AD, Winter JM, Sawicki JA, Sachs JN, Meisner-Kober N, Yeo CJ, Vadigepalli R, Tykocinski ML, Brody JR. HuR Contributes to TRAIL Resistance by Restricting Death Receptor 4 Expression in Pancreatic Cancer Cells. Mol Cancer Res. 2016 Jul; 14(7):599-611. PMID: 27053682.
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    6. Hojat M, Michalec B, Veloski JJ, Tykocinski ML. Can empathy, other personality attributes, and level of positive social influence in medical school identify potential leaders in medicine? Acad Med. 2015 Apr; 90(4):505-10. PMID: 25629944.
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    7. Michalec B, Veloski JJ, Hojat M, Tykocinski ML. Identifying potential engaging leaders within medical education: The role of positive influence on peers. Med Teach. 2014 Aug 26; 1-7. PMID: 25155553.
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    8. Aronin A, Amsili S, Prigozhina TB, Tzdaka K, Rachmilewitz J, Shani N, Tykocinski ML, Dranitzki Elhalel M. Fn14•TRAIL effectively inhibits hepatocellular carcinoma growth. PLoS One. 2013; 8(10):e77050. PMID: 24130833.
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    9. Martinez-Outschoorn UE, Pestell RG, Howell A, Tykocinski ML, Nagajyothi F, Machado FS, Tanowitz HB, Sotgia F, Lisanti MP. Energy transfer in "parasitic" cancer metabolism: mitochondria are the powerhouse and Achilles' heel of tumor cells. Cell Cycle. 2011 Dec 15; 10(24):4208-16. PMID: 22033146.
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    10. Orbach A, Rachmilewitz J, Shani N, Isenberg Y, Parnas M, Huang JH, Tykocinski ML, Dranitzki-Elhalel M. CD40·FasL and CTLA-4·FasL fusion proteins induce apoptosis in malignant cell lines by dual signaling. Am J Pathol. 2010 Dec; 177(6):3159-68. PMID: 21088216.
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    11. Ochanuna Z, Geiger-Maor A, Dembinsky-Vaknin A, Karussis D, Tykocinski ML, Rachmilewitz J. Inhibition of effector function but not T cell activation and increase in FoxP3 expression in T cells differentiated in the presence of PP14. PLoS One. 2010; 5(9):e12868. PMID: 20886106.
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    12. Razmara M, Hilliard B, Ziarani AK, Murali R, Yellayi S, Ghazanfar M, Chen YH, Tykocinski ML. Fn14-TRAIL, a chimeric intercellular signal exchanger, attenuates experimental autoimmune encephalomyelitis. Am J Pathol. 2009 Feb; 174(2):460-74. PMID: 19147815.
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    13. Razmara M, Hilliard B, Ziarani AK, Chen YH, Tykocinski ML. CTLA-4 x Ig converts naive CD4+CD25- T cells into CD4+CD25+ regulatory T cells. Int Immunol. 2008 Apr; 20(4):471-83. PMID: 18272926.
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    14. Tone Y, Furuuchi K, Kojima Y, Tykocinski ML, Greene MI, Tone M. Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer. Nat Immunol. 2008 Feb; 9(2):194-202. PMID: 18157133.
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    15. Orbach A, Rachmilewitz J, Parnas M, Huang JH, Tykocinski ML, Dranitzki-Elhalel M. CTLA-4 . FasL induces early apoptosis of activated T cells by interfering with anti-apoptotic signals. J Immunol. 2007 Dec 1; 179(11):7287-94. PMID: 18025171.
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    16. Tone Y, Kojima Y, Furuuchi K, Brady M, Yashiro-Ohtani Y, Tykocinski ML, Tone M. OX40 gene expression is up-regulated by chromatin remodeling in its promoter region containing Sp1/Sp3, YY1, and NF-kappa B binding sites. J Immunol. 2007 Aug 1; 179(3):1760-7. PMID: 17641042.
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    17. Dranitzki-Elhalel M, Huang JH, Sasson M, Rachmilewitz J, Parnas M, Tykocinski ML. CD40.FasL inhibits human T cells: evidence for an auto-inhibitory loop-back mechanism. Int Immunol. 2007 Apr; 19(4):355-63. PMID: 17314083.
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    18. Dranitzki-Elhalel M, Huang JH, Rachmilewitz J, Pappo O, Parnas M, Schmidt W, Tykocinski ML. CTLA-4.FasL inhibits allogeneic responses in vivo. Cell Immunol. 2006 Feb; 239(2):129-35. PMID: 16828466.
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    19. Ish-Shalom E, Gargir A, André S, Borovsky Z, Ochanuna Z, Gabius HJ, Tykocinski ML, Rachmilewitz J. alpha2,6-Sialylation promotes binding of placental protein 14 via its Ca2+-dependent lectin activity: insights into differential effects on CD45RO and CD45RA T cells. Glycobiology. 2006 Mar; 16(3):173-83. PMID: 16269626.
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    20. Crawford JM, Tykocinski ML. Pathology as the enabler of human research. Lab Invest. 2005 Sep; 85(9):1058-64. PMID: 16056243.
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    21. Mishan-Eisenberg G, Borovsky Z, Weber MC, Gazit R, Tykocinski ML, Rachmilewitz J. Differential regulation of Th1/Th2 cytokine responses by placental protein 14. J Immunol. 2004 Nov 1; 173(9):5524-30. PMID: 15494501.
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    22. Skornicka EL, Kiyatkina N, Weber MC, Tykocinski ML, Koo PH. Pregnancy zone protein is a carrier and modulator of placental protein-14 in T-cell growth and cytokine production. Cell Immunol. 2004 Nov-Dec; 232(1-2):144-56. PMID: 15882859.
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    23. Elhalel MD, Huang JH, Schmidt W, Rachmilewitz J, Tykocinski ML. CTLA-4. FasL induces alloantigen-specific hyporesponsiveness. J Immunol. 2003 Jun 15; 170(12):5842-50. PMID: 12794109.
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    24. Chen A, Zheng G, Tykocinski ML. Quantitative interplay between activating and pro-apoptotic signals dictates T cell responses. Cell Immunol. 2003 Feb; 221(2):128-37. PMID: 12747954.
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    25. Rachmilewitz J, Borovsky Z, Riely GJ, Miller R, Tykocinski ML. Negative regulation of T cell activation by placental protein 14 is mediated by the tyrosine phosphatase receptor CD45. J Biol Chem. 2003 Apr 18; 278(16):14059-65. PMID: 12556471.
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    26. Tykocinski ML, Chen A, Huang JH, Weber MC, Zheng G. New designs for cancer vaccine and artificial veto cells: an emerging palette of protein paints. Immunol Res. 2003; 27(2-3):565-74. PMID: 12857999.
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    27. Moody DB, Briken V, Cheng TY, Roura-Mir C, Guy MR, Geho DH, Tykocinski ML, Besra GS, Porcelli SA. Lipid length controls antigen entry into endosomal and nonendosomal pathways for CD1b presentation. Nat Immunol. 2002 May; 3(5):435-42. PMID: 11938350.
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    28. Rachmilewitz J, Borovsky Z, Mishan-Eisenberg G, Yaniv E, Riely GJ, Tykocinski ML. Focal localization of placental protein 14 toward sites of TCR engagement. J Immunol. 2002 Mar 15; 168(6):2745-50. PMID: 11884441.
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    29. Rachmilewitz J, Riely GJ, Huang JH, Chen A, Tykocinski ML. A rheostatic mechanism for T-cell inhibition based on elevation of activation thresholds. Blood. 2001 Dec 15; 98(13):3727-32. PMID: 11739178.
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    30. Zheng G, Chen A, Sterner RE, Zhang PJ, Pan T, Kiyatkin N, Tykocinski ML. Induction of antitumor immunity via intratumoral tetra-costimulator protein transfer. Cancer Res. 2001 Nov 15; 61(22):8127-34. PMID: 11719441.
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    31. Huang JH, Tykocinski ML. CTLA-4-Fas ligand functions as a trans signal converter protein in bridging antigen-presenting cells and T cells. Int Immunol. 2001 Apr; 13(4):529-39. PMID: 11282992.
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    32. Premkumar DR, Fukuoka Y, Sevlever D, Brunschwig E, Rosenberry TL, Tykocinski ML, Medof ME. Properties of exogenously added GPI-anchored proteins following their incorporation into cells. J Cell Biochem. 2001; 82(2):234-45. PMID: 11527149.
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    33. Riely GJ, Rachmilewitz J, Koo PH, Tykocinski ML. alpha2-macroglobulin modulates the immunoregulatory function of the lipocalin placental protein 14. Biochem J. 2000 Oct 15; 351 Pt 2:503-8. PMID: 11023837.
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    34. Banet G, Bibi O, Matouk I, Ayesh S, Laster M, Kimber KM, Tykocinski M, de Groot N, Hochberg A, Ohana P. Characterization of human and mouse H19 regulatory sequences. Mol Biol Rep. 2000 Sep; 27(3):157-65. PMID: 11254105.
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    35. Geho DH, Fayen JD, Jackman RM, Moody DB, Porcelli SA, Tykocinski ML. Glycosyl-phosphatidylinositol reanchoring unmasks distinct antigen-presenting pathways for CD1b and CD1c. J Immunol. 2000 Aug 1; 165(3):1272-7. PMID: 10903726.
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    36. Chen A, Zheng G, Tykocinski ML. Hierarchical costimulator thresholds for distinct immune responses: application of a novel two-step Fc fusion protein transfer method. J Immunol. 2000 Jan 15; 164(2):705-11. PMID: 10623813.
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    37. Fayen JD, Tykocinski ML, Medof ME. Glycerolphosphoinositide anchors for membrane-tethering proteins. Methods Enzymol. 2000; 327:351-68. PMID: 11044996.
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    38. Brunschwig EB, Fayen JD, Medof ME, Tykocinski ML. Protein transfer of glycosyl-phosphatidylinositol (GPI)-modified murine B7-1 and B7-2 costimulators. J Immunother. 1999 Sep; 22(5):390-400. PMID: 10546154.
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    39. Tanos V, Prus D, Ayesh S, Weinstein D, Tykocinski ML, De-Groot N, Hochberg A, Ariel I. Expression of the imprinted H19 oncofetal RNA in epithelial ovarian cancer. Eur J Obstet Gynecol Reprod Biol. 1999 Jul; 85(1):7-11. PMID: 10428315.
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    40. Rachmilewitz J, Riely GJ, Tykocinski ML. Placental protein 14 functions as a direct T-cell inhibitor. Cell Immunol. 1999 Jan 10; 191(1):26-33. PMID: 9918684.
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    41. Weber MC, Groger RK, Tykocinski ML. Antisense modulation of the ICAM-1 phenotype of a model human bone marrow stromal cell line. Exp Cell Res. 1998 Oct 10; 244(1):239-48. PMID: 9770366.
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    42. Miller RE, Fayen JD, Chakraborty S, Weber MC, Tykocinski ML. A receptor for the lipocalin placental protein 14 on human monocytes. FEBS Lett. 1998 Oct 9; 436(3):455-60. PMID: 9801168.
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    43. Fayen J, Huang JH, Ferrone S, Tykocinski ML. Negative signaling by anti-HLA class I antibodies is dependent upon two triggering events. Int Immunol. 1998 Sep; 10(9):1347-58. PMID: 9786434.
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    44. Rachmilewitz J, Tykocinski ML. Differential effects of chondroitin sulfates A and B on monocyte and B-cell activation: evidence for B-cell activation via a CD44-dependent pathway. Blood. 1998 Jul 1; 92(1):223-9. PMID: 9639520.
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    45. Chen A, Meyerson HJ, Salvekar A, Tykocinski ML. Non-glycosylated human B7-1(CD80) retains the capacity to bind its counter-receptors. FEBS Lett. 1998 May 29; 428(3):127-34. PMID: 9654121.
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    46. Muschel RJ, Tykocinski M, Padarathsingh M. Link between tumor progression, proteases, and cell motility. Pathology B workshop. Am J Pathol. 1996 Sep; 149(3):1073-6. PMID: 8780409.
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    47. Meyerson HJ, Huang JH, Fayen JD, Tsao HM, Getty RR, Greenspan NS, Tykocinski ML. Functional dissociation of CD8 alpha's Ig homologue and connecting peptide domains. J Immunol. 1996 Jan 15; 156(2):574-84. PMID: 8543808.
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    48. Tykocinski ML, Kaplan DR, Medof ME. Antigen-presenting cell engineering. The molecular toolbox. Am J Pathol. 1996 Jan; 148(1):1-16. PMID: 8546197.
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    49. Tykocinski ML, Xiong N, Morrow DM. Platelet immunoregulatory factors. Stem Cells. 1996; 14 Suppl 1:240-5. PMID: 11012227.
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    50. Brunschwig EB, Levine E, Trefzer U, Tykocinski ML. Glycosylphosphatidylinositol-modified murine B7-1 and B7-2 retain costimulator function. J Immunol. 1995 Dec 15; 155(12):5498-505. PMID: 7499830.
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    51. Matrisian LM, Tykocinski ML, Padarathsingh M. Lessons to be learned from hematopoietic malignancies. Workshop report from the Division of Research Grants, National Institutes of Health. Am J Pathol. 1995 Nov; 147(5):1519-21. PMID: 7485414.
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    52. Fayen J, Huang JH, Meyerson H, Zhang D, Getty R, Greenspan N, Tykocinski M. Class I MHC alpha 3 domain can function as an independent structural unit to bind CD8 alpha. Mol Immunol. 1995 Mar; 32(4):267-75. PMID: 7723772.
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    53. Morrow DM, Xiong N, Getty RR, Ratajczak MZ, Morgan D, Seppala M, Riittinen L, Gewirtz AM, Tykocinski ML. Hematopoietic placental protein 14. An immunosuppressive factor in cells of the megakaryocytic lineage. Am J Pathol. 1994 Dec; 145(6):1485-95. PMID: 7992851.
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    54. Huang JH, Getty RR, Chisari FV, Fowler P, Greenspan NS, Tykocinski ML. Protein transfer of preformed MHC-peptide complexes sensitizes target cells to T cell cytolysis. Immunity. 1994 Oct; 1(7):607-13. PMID: 7600289.
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    55. Huang JH, Greenspan NS, Tykocinski ML. Alloantigenic recognition of artificial glycosyl phosphatidylinositol-anchored HLA-A2.1. Mol Immunol. 1994 Sep; 31(13):1017-28. PMID: 8084336.
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    56. Weber MC, Tykocinski ML. Bone marrow stromal cell blockade of human leukemic cell differentiation. Blood. 1994 Apr 15; 83(8):2221-9. PMID: 7512844.
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    57. Singh N, Zoeller RA, Tykocinski ML, Lazarow PB, Tartakoff AM. Addition of lipid substituents of mammalian protein glycosylphosphoinositol anchors. Mol Cell Biol. 1994 Jan; 14(1):21-31. PMID: 8264589.
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    58. Weber MC, Groger RK, Tykocinski ML. A glycosylphosphatidylinositol-anchored cytokine can function as an artificial cellular adhesin. Exp Cell Res. 1994 Jan; 210(1):107-12. PMID: 8269987.
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    59. Liang X, Tang M, Zamb TJ, Babiuk LA, Kowalski J, Tykocinski ML. Expression of glycoprotein gIII-human decay-accelerating factor chimera on the bovine herpesvirus 1 virion via a glycosyl phosphatidylinositol-based membrane anchor. J Virol. 1993 Aug; 67(8):4896-904. PMID: 7687305.
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    60. Hambor JE, Kaplan DR, Tykocinski ML. CD8 functions as an inhibitory ligand in mediating the immunoregulatory activity of CD8+ cells. J Immunol. 1990 Sep 15; 145(6):1646-52. PMID: 1697305.
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    61. Hambor JE, Weber MC, Tykocinski ML, Kaplan DR. Regulation of allogeneic responses by expression of CD8 alpha chain on stimulator cells. Int Immunol. 1990; 2(9):879-83. PMID: 2149069.
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    62. Kaplan DR, Hambor JE, Tykocinski ML. An immunoregulatory function for the CD8 molecule. Proc Natl Acad Sci U S A. 1989 Nov; 86(21):8512-5. PMID: 2510168.
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    63. Hambor JE, Tykocinski ML, Kaplan DR. Functional consequences of anti-sense RNA-mediated inhibition of CD8 surface expression in a human T cell clone. J Exp Med. 1988 Oct 1; 168(4):1237-45. PMID: 2459296.
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    64. Tykocinski ML, Shu HK, Ayers DJ, Walter EI, Getty RR, Groger RK, Hauer CA, Medof ME. Glycolipid reanchoring of T-lymphocyte surface antigen CD8 using the 3' end sequence of decay-accelerating factor's mRNA. Proc Natl Acad Sci U S A. 1988 May; 85(10):3555-9. PMID: 2453063.
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    65. Werber HI, Emancipator SN, Tykocinski ML, Sedor JR. The interleukin 1 gene is expressed by rat glomerular mesangial cells and is augmented in immune complex glomerulonephritis. J Immunol. 1987 May 15; 138(10):3207-12. PMID: 2883234.
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    66. Tykocinski ML, Marche PN, Max EE, Kindt TJ. Rabbit class I MHC genes: cDNA clones define full-length transcripts of an expressed gene and a putative pseudogene. J Immunol. 1984 Oct; 133(4):2261-9. PMID: 6432910.
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