Thomas Jefferson University

Matthew Dalva

TitleResearcher
InstitutionThomas Jefferson University
DepartmentDepartment of Neurosciences
Address233 S. 10th Street
Philadelphia PA 19107
Phone215-503-0997
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    R01MH073357     (DALVA, MATTHEW B)Aug 23, 2004 - Jul 31, 2008
    NIH
    CRCNS Spontan. Activ. Lateral Interactions &Cort. Maps
    Role: Principal Investigator
    R01DA022727     (DALVA, MATTHEW B)Dec 1, 2006 - Nov 30, 2025
    NIH
    Cell-Contact Mediated Mechanisms Assembling Synapses (R01DA022727)
    Role: Principal Investigator
    R01MH086425     (DALVA, MATTHEW B)Jul 17, 2009 - Apr 30, 2015
    NIH
    Genetic indicators for dynamic imaging of neuronal signaling in plasticity and de
    Role: Principal Investigator
    R01MH100093     (DALVA, MATTHEW B)Jul 1, 2013 - Apr 30, 2018
    NIH
    Glial Control of Neuronal Progenitor Cell Migration
    Role: Principal Investigator
    R01NS106906     (DALVA, MATTHEW B)May 15, 2018 - Apr 30, 2024
    NIH
    Examining the function of biological sex specific genes: the NLGN4s
    Role: Principal Investigator
    R01NS110385     (LEPORE, ANGELO C)Sep 1, 2018 - Jun 30, 2029
    NIH
    Exploring the EphB2-NMDA receptor interaction in spinal cord injury-induced neuropathic pain
    Role: Co-Principal Investigator
    R01NS111976     (DALVA, MATTHEW B)Sep 1, 2019 - Jul 31, 2024
    NIH
    Extracellular mechanism regulating synaptic function and pain plasticity
    Role: Principal Investigator
    R01NS115441     (DALVA, MATTHEW B)Dec 15, 2019 - Nov 30, 2024
    NIH
    Novel mechanisms regulating protein interaction and pain
    Role: Principal Investigator
    R01MH138995     (HAHN, CHANG-GYU)Dec 1, 2024 - Nov 30, 2029
    NIH
    Pathophysiologic roles of protein-protein interactions at excitatory synapses and their modifications in schizophrenia
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Jafri H, Thomas SJ, Yang SH, Cain RE, Dalva MB. Nano-organization of synapses defines synaptic release properties at cortical neuron dendritic spines. bioRxiv. 2025 Mar 29. PMID: 39990496.
      Citations:    
    2. David ET, Yousuf MS, Mei HR, Jain A, Krishnagiri S, Elahi H, Venkatesan R, Srikanth KD, Dussor G, Dalva MB, Price TJ. ephrin-B2 promotes nociceptive plasticity and hyperalgesic priming through EphB2-MNK-eIF4E signaling in both mice and humans. Pharmacol Res. 2024 Jun 24; 107284. PMID: 38925462.
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    3. Srikanth KD, Elahi H, Chander P, Washburn HR, Hassler S, Mwirigi JM, Kume M, Loucks J, Arjarapu R, Hodge R, Shiers SI, Sankaranarayanan I, Erdjument-Bromage H, Neubert TA, Campbell ZT, Paik R, Price TJ, Dalva MB. VLK drives extracellular phosphorylation of EphB2 to govern the EphB2-NMDAR interaction and injury-induced pain. bioRxiv. 2024 Mar 18. PMID: 38562765.
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    4. Urban MW, Charsar BA, Heinsinger NM, Markandaiah SS, Sprimont L, Zhou W, Brown EV, Henderson NT, Thomas SJ, Ghosh B, Cain RE, Trotti D, Pasinelli P, Wright MC, Dalva MB, Lepore AC. EphrinB2 knockdown in cervical spinal cord preserves diaphragm innervation in a mutant SOD1 mouse model of ALS. Elife. 2024 Jan 15; 12. PMID: 38224498.
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    5. Dalva MB. Brain cancer thrives by hijacking mechanisms to boost synapse strength. Nature. 2023 Nov; 623(7986):260-262. PMID: 37932559.
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    6. Gardeazabal Rodriguez PF, Lilach Y, Ambegaonkar A, Vitali T, Jafri H, Sohn HW, Dalva M, Pierce S, Chung I. MAxSIM: multi-angle-crossing structured illumination microscopy with height-controlled mirror for 3D topological mapping of live cells. Commun Biol. 2023 Oct 12; 6(1):1034. PMID: 37828050.
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    7. Ogunmowo TH, Jing H, Raychaudhuri S, Kusick GF, Imoto Y, Li S, Itoh K, Ma Y, Jafri H, Dalva MB, Chapman ER, Ha T, Watanabe S, Liu J. Membrane compression by synaptic vesicle exocytosis triggers ultrafast endocytosis. Nat Commun. 2023 May 20; 14(1):2888. PMID: 37210439.
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    8. Urban MW, Charsar BA, Heinsinger NM, Markandaiah SS, Sprimont L, Zhou W, Henderson NT, Ghosh B, Cain RE, Trotti D, Pasinelli P, Wright MC, Dalva MB, Lepore AC. EphrinB2 knockdown in spinal cord astrocytes preserves diaphragm innervation in a mutant SOD1 mouse model of ALS. bioRxiv. 2023 May 10. PMID: 37215009.
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    9. Washburn HR, Chander P, Srikanth KD, Dalva MB. Transsynaptic Signaling of Ephs in Synaptic Development, Plasticity, and Disease. Neuroscience. 2023 Jan 01; 508:137-152. PMID: 36460219.
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    10. Hruska M, Cain RE, Dalva MB. Nanoscale rules governing the organization of glutamate receptors in spine synapses are subunit specific. Nat Commun. 2022 02 17; 13(1):920. PMID: 35177616.
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    11. Hanamura K, Washburn HR, Sheffler-Collins SI, Xia NL, Henderson N, Tillu DV, Hassler S, Spellman DS, Zhang G, Neubert TA, Price TJ, Dalva MB. Correction: Extracellular phosphorylation of a receptor tyrosine kinase controls synaptic localization of NMDA receptors and regulates pathological pain. PLoS Biol. 2021 Nov; 19(11):e3001452. PMID: 34752444.
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    12. Xu Y, Robev D, Saha N, Wang B, Dalva MB, Xu K, Himanen JP, Nikolov DB. The Ephb2 Receptor Uses Homotypic, Head-to-Tail Interactions within Its Ectodomain as an Autoinhibitory Control Mechanism. Int J Mol Sci. 2021 Sep 28; 22(19). PMID: 34638814.
      Citations:    
    13. Washburn HR, Xia NL, Zhou W, Mao YT, Dalva MB. Positive surface charge of GluN1 N-terminus mediates the direct interaction with EphB2 and NMDAR mobility. Nat Commun. 2020 Jan 29; 11(1):570. PMID: 31996679.
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    14. Henderson NT, Le Marchand SJ, Hruska M, Hippenmeyer S, Luo L, Dalva MB. Ephrin-B3 controls excitatory synapse density through cell-cell competition for EphBs. Elife. 2019 Feb 21; 8. PMID: 30789343.
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    15. Barber KR, Hruska M, Bush KM, Martinez JA, Fei H, Levitan IB, Dalva MB, Wairkar YP. Levels of Par-1 kinase determine the localization of Bruchpilot at the Drosophila neuromuscular junction synapses. Sci Rep. 2018 Oct 31; 8(1):16099. PMID: 30382129.
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    16. Henderson NT, Dalva MB. EphBs and ephrin-Bs: Trans-synaptic organizers of synapse development and function. Mol Cell Neurosci. 2018 Sep; 91:108-121. PMID: 30031105.
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    17. Mao YT, Zhu JX, Hanamura K, Iurilli G, Datta SR, Dalva MB. Filopodia Conduct Target Selection in Cortical Neurons Using Differences in Signal Kinetics of a Single Kinase. Neuron. 2018 May 16; 98(4):767-782.e8. PMID: 29731254.
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    18. Hruska M, Henderson N, Le Marchand SJ, Jafri H, Dalva MB. Synaptic nanomodules underlie the organization and plasticity of spine synapses. Nat Neurosci. 2018 May; 21(5):671-682. PMID: 29686261.
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    19. Hanamura K, Washburn HR, Sheffler-Collins SI, Xia NL, Henderson N, Tillu DV, Hassler S, Spellman DS, Zhang G, Neubert TA, Price TJ, Dalva MB. Extracellular phosphorylation of a receptor tyrosine kinase controls synaptic localization of NMDA receptors and regulates pathological pain. PLoS Biol. 2017 Jul; 15(7):e2002457. PMID: 28719605.
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    20. Poliak S, Morales D, Croteau LP, Krawchuk D, Palmesino E, Morton S, Cloutier JF, Charron F, Dalva MB, Ackerman SL, Kao TJ, Kania A. Synergistic integration of Netrin and ephrin axon guidance signals by spinal motor neurons. Elife. 2015; 4. PMID: 26633881.
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    21. Hruska M, Henderson NT, Xia NL, Le Marchand SJ, Dalva MB. Anchoring and synaptic stability of PSD-95 is driven by ephrin-B3. Nat Neurosci. 2015 Nov; 18(11):1594-605. PMID: 26479588.
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    22. Jepson JE, Shahidullah M, Liu D, le Marchand SJ, Liu S, Wu MN, Levitan IB, Dalva MB, Koh K. Regulation of synaptic development and function by the Drosophila PDZ protein Dyschronic. Development. 2014 Dec; 141(23):4548-57. PMID: 25359729.
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    23. Shahidullah M, Le Marchand SJ, Fei H, Zhang J, Pandey UB, Dalva MB, Pasinelli P, Levitan IB. Defects in Synapse Structure and Function Precede Motor Neuron Degeneration in Drosophila Models of FUS-Related ALS. J Neurosci. 2013 Dec 11; 33(50):19590-8. PMID: 24336723.
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    24. Dai J, Buhusi M, Demyanenko GP, Brennaman LH, Hruska M, Dalva MB, Maness PF. Neuron Glia-Related Cell Adhesion Molecule (NrCAM) Promotes Topographic Retinocollicular Mapping. PLoS One. 2013; 8(9):e73000. PMID: 24023801.
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    25. Sheffler-Collins SI, Dalva MB. EphBs: an integral link between synaptic function and synaptopathies. Trends Neurosci. 2012 May; 35(5):293-304. PMID: 22516618.
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    26. Hruska M, Dalva MB. Ephrin regulation of synapse formation, function and plasticity. Mol Cell Neurosci. 2012 May; 50(1):35-44. PMID: 22449939.
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    27. Nolt MJ, Lin Y, Hruska M, Murphy J, Sheffler-Colins SI, Kayser MS, Passer J, Bennett MV, Zukin RS, Dalva MB. EphB controls NMDA receptor function and synaptic targeting in a subunit-specific manner. J Neurosci. 2011 Apr 6; 31(14):5353-64. PMID: 21471370.
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    28. Kayser MS, Lee AC, Hruska M, Dalva MB. Preferential control of basal dendritic protrusions by EphB2. PLoS One. 2011; 6(2):e17417. PMID: 21364901.
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    29. Dalva MB. Ephecting excitatory synapse development. Cell. 2010 Oct 29; 143(3):341-2. PMID: 21029857.
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    30. Antion MD, Christie LA, Bond AM, Dalva MB, Contractor A. Ephrin-B3 regulates glutamate receptor signaling at hippocampal synapses. Mol Cell Neurosci. 2010 Dec; 45(4):378-88. PMID: 20678574.
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    31. McClelland AC, Hruska M, Coenen AJ, Henkemeyer M, Dalva MB. Trans-synaptic EphB2-ephrin-B3 interaction regulates excitatory synapse density by inhibition of postsynaptic MAPK signaling. Proc Natl Acad Sci U S A. 2010 May 11; 107(19):8830-5. PMID: 20410461.
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    32. Dalva MB. Remodeling of inhibitory synaptic connections in developing ferret visual cortex. Neural Dev. 2010; 5:5. PMID: 20122141.
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    33. McClelland AC, Sheffler-Collins SI, Kayser MS, Dalva MB. Ephrin-B1 and ephrin-B2 mediate EphB-dependent presynaptic development via syntenin-1. Proc Natl Acad Sci U S A. 2009 Dec 1; 106(48):20487-92. PMID: 19915143.
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    34. Dalva MB. Neuronal activity moves protein palmitoylation into the synapse. J Cell Biol. 2009 Jul 13; 186(1):7-9. PMID: 19596846.
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    35. Kayser MS, Nolt MJ, Dalva MB. EphB receptors couple dendritic filopodia motility to synapse formation. Neuron. 2008 Jul 10; 59(1):56-69. PMID: 18614029.
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    36. Dalva MB. There's more than one way to skin a chimaerin. Neuron. 2007 Sep 6; 55(5):681-4. PMID: 17785174.
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    37. Dalva MB, McClelland AC, Kayser MS. Cell adhesion molecules: signalling functions at the synapse. Nat Rev Neurosci. 2007 Mar; 8(3):206-20. PMID: 17299456.
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    38. Kayser MS, McClelland AC, Hughes EG, Dalva MB. Intracellular and trans-synaptic regulation of glutamatergic synaptogenesis by EphB receptors. J Neurosci. 2006 Nov 22; 26(47):12152-64. PMID: 17122040.
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    39. Takasu MA, Dalva MB, Zigmond RE, Greenberg ME. Modulation of NMDA receptor-dependent calcium influx and gene expression through EphB receptors. Science. 2002 Jan 18; 295(5554):491-5. PMID: 11799243.
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