Thomas Jefferson University

My Mahoney

TitleProfessor
InstitutionThomas Jefferson University
DepartmentCancer Biology
Address233 S. 10th Street
Philadelphia PA 19107
Phone215-503-3240
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    R03AR047938     (MAHONEY, MY GEORGIA)Sep 28, 2001 - Feb 28, 2005
    NIH
    Desmoglein 2 Function in Cell Adhesion and Pemphigus
    Role: Principal Investigator
    R21AR055251     (MAHONEY, MY GEORGIA)Sep 7, 2007 - Aug 31, 2009
    NIH
    Desmosomal components and epithelial cell fate decision
    Role: Principal Investigator
    R01AR056067     (MAHONEY, MY GEORGIA)Dec 1, 2009 - Sep 30, 2015
    NIH
    Role of Desmosomal Adhesion in Carcinogenesis
    Role: Principal Investigator
    R01AR074314     (MAHONEY, MY GEORGIA)Aug 1, 2018 - May 31, 2023
    NIH
    Effects of extracellular vesicles on miRNA activity in the skin
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Estephan LE, Kumar G, Stewart M, Banoub R, Linnenbach A, Harshyne LA, Martinez-Outschoorn UE, Mahoney MG, Curry JM, Johnson J, South AP, Luginbuhl AJ. Altered extracellular matrix correlates with an immunosuppressive tumor microenvironment and disease progression in younger adults with oral cavity squamous cell carcinoma. Front Oncol. 2024; 14:1412212. PMID: 38957320.
      Citations:    
    2. Myo Min KK, Rojas-Canales D, Penko D, DeNichilo M, Cockshell MP, Ffrench CB, Thompson EJ, Asplund O, Drogemuller CJ, Prasad RB, Groop L, Grey ST, Thomas HE, Loudovaris T, Kay TW, Mahoney MG, Jessup CF, Coates PT, Bonder CS. Desmoglein-2 is important for islet function and ?-cell survival. Cell Death Dis. 2022 10 29; 13(10):911. PMID: 36309486.
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    3. Luginbuhl AJ, Johnson JM, Harshyne LA, Linnenbach AJ, Shukla SK, Alnemri A, Kumar G, Cognetti DM, Curry JM, Kotlov N, Antysheva Z, Degryse S, Mannion K, Gibson MK, Netterville J, Brown B, Axelrod R, Zinner R, Tuluc M, Gargano S, Leiby BE, Shimada A, Mahoney MG, Martinez-Outschoorn U, Rodeck U, Kim YJ, South AP, Argiris A. Tadalafil Enhances Immune Signatures in Response to Neoadjuvant Nivolumab in Resectable Head and Neck Squamous Cell Carcinoma. Clin Cancer Res. 2022 Mar 01; 28(5):915-927. PMID: 34911681.
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    4. Curry JM, Johnson J, Mollaee M, Tassone P, Amin D, Knops A, Whitaker-Menezes D, Mahoney MG, South A, Rodeck U, Zhan T, Harshyne L, Philp N, Luginbuhl A, Cognetti D, Tuluc M, Martinez-Outschoorn U. Metformin Clinical Trial in HPV+ and HPV- Head and Neck Squamous Cell Carcinoma: Impact on Cancer Cell Apoptosis and Immune Infiltrate. Front Oncol. 2018; 8:436. PMID: 30364350.
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    5. Hariton WVJ, Galichet A, Vanden Berghe T, Overmiller AM, Mahoney MG, Declercq W, Müller EJ. Feasibility study for clinical application of caspase-3 inhibitors in Pemphigus vulgaris. Exp Dermatol. 2017 Dec; 26(12):1274-1277. PMID: 29105150.
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    6. Zhang QS, Kurpad DS, Mahoney MG, Steinbeck MJ, Freeman TA. Inhibition of apoptosis signal-regulating kinase 1 alters the wound epidermis and enhances auricular cartilage regeneration. PLoS One. 2017; 12(10):e0185803. PMID: 29045420.
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    7. Roberts BJ, Svoboda RA, Overmiller AM, Lewis JD, Kowalczyk AP, Mahoney MG, Johnson KR, Wahl JK. Palmitoylation of Desmoglein 2 is a Regulator of Assembly Dynamics and Protein Turnover. J Biol Chem. 2016 Oct 4. PMID: 27703000.
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    8. Roberts BJ, Johnson KE, McGuinn KP, Saowapa J, Svoboda RA, Mahoney MG, Johnson KR, Wahl JK. Palmitoylation of plakophilin is required for desmosome assembly. J Cell Sci. 2014 Sep 1; 127(Pt 17):3782-93. PMID: 25002405.
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    9. Longmate WM, Monichan R, Chu ML, Tsuda T, Mahoney MG, DiPersio CM. Reduced Fibulin-2 Contributes to Loss of Basement Membrane Integrity and Skin Blistering in Mice Lacking Integrin a3ß1 in the Epidermis. J Invest Dermatol. 2014 Jun; 134(6):1609-17. PMID: 24390135.
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    10. Brennan D, Chen X, Cheng L, Mahoney M, Riobo NA. Noncanonical Hedgehog signaling. Vitam Horm. 2012; 88:55-72. PMID: 22391299.
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    11. El-Domyati M, El-Ammawi TS, Moawad O, Medhat W, Mahoney MG, Uitto J. Intense pulsed light photorejuvenation: a histological and immunohistochemical evaluation. J Drugs Dermatol. 2011 Nov; 10(11):1246-52. PMID: 22052303.
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    12. el-Domyati M, el-Ammawi TS, Medhat W, Moawad O, Brennan D, Mahoney MG, Uitto J. Radiofrequency facial rejuvenation: evidence-based effect. J Am Acad Dermatol. 2011 Mar; 64(3):524-35. PMID: 21315951.
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    13. El-Domyati M, El-Ammawi TS, Medhat W, Moawad O, Mahoney MG, Uitto J. Electro-optical Synergy Technique: A New and Effective Nonablative Approach to Skin Aging. J Clin Aesthet Dermatol. 2010 Dec; 3(12):22-30. PMID: 21203352.
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    14. Brennan D, Hu Y, Medhat W, Dowling A, Mahoney MG. Superficial dsg2 expression limits epidermal blister formation mediated by pemphigus foliaceus antibodies and exfoliative toxins. Dermatol Res Pract. 2010; 2010:410278. PMID: 20631906.
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    15. Mahoney MG, Sadowski S, Brennan D, Pikander P, Saukko P, Wahl J, Aho H, Heikinheimo K, Bruckner-Tuderman L, Fertala A, Peltonen J, Uitto J, Peltonen S. Compound heterozygous desmoplakin mutations result in a phenotype with a combination of myocardial, skin, hair, and enamel abnormalities. J Invest Dermatol. 2010 Apr; 130(4):968-78. PMID: 19924139.
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    16. Mahoney MG, Brennan D, Starcher B, Faryniarz J, Ramirez J, Parr L, Uitto J. Extracellular matrix in cutaneous ageing: the effects of 0.1% copper-zinc malonate-containing cream on elastin biosynthesis. Exp Dermatol. 2009 Mar; 18(3):205-11. PMID: 19400831.
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    17. Stojadinovic O, Pastar I, Vukelic S, Mahoney MG, Brennan D, Krzyzanowska A, Golinko M, Brem H, Tomic-Canic M. Deregulation of keratinocyte differentiation and activation: a hallmark of venous ulcers. J Cell Mol Med. 2008 Dec; 12(6B):2675-90. PMID: 18373736.
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    18. Sobolik-Delmaire T, Katafiasz D, Keim SA, Mahoney MG, Wahl JK. Decreased plakophilin-1 expression promotes increased motility in head and neck squamous cell carcinoma cells. Cell Commun Adhes. 2007 Mar-Jun; 14(2-3):99-109. PMID: 17668353.
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    19. Brennan D, Hu Y, Joubeh S, Choi YW, Whitaker-Menezes D, O'Brien T, Uitto J, Rodeck U, Mahoney MG. Suprabasal Dsg2 expression in transgenic mouse skin confers a hyperproliferative and apoptosis-resistant phenotype to keratinocytes. J Cell Sci. 2007 Mar 1; 120(Pt 5):758-71. PMID: 17284515.
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    20. Bazzi H, Getz A, Mahoney MG, Ishida-Yamamoto A, Langbein L, Wahl JK, Christiano AM. Desmoglein 4 is expressed in highly differentiated keratinocytes and trichocytes in human epidermis and hair follicle. Differentiation. 2006 Mar; 74(2-3):129-40. PMID: 16533311.
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    21. Mahoney MG, Hu Y, Brennan D, Bazzi H, Christiano AM, Wahl JK. Delineation of diversified desmoglein distribution in stratified squamous epithelia: implications in diseases. Exp Dermatol. 2006 Feb; 15(2):101-9. PMID: 16433681.
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    22. Brennan D, Hu Y, Kljuic A, Choi Y, Joubeh S, Bashkin M, Wahl J, Fertala A, Pulkkinen L, Uitto J, Christiano AM, Panteleyev A, Mahoney MG. Differential structural properties and expression patterns suggest functional significance for multiple mouse desmoglein 1 isoforms. Differentiation. 2004 Oct; 72(8):434-49. PMID: 15606502.
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    23. Mishra SK, Talukder AH, Gururaj AE, Yang Z, Singh RR, Mahoney MG, Francí C, Vadlamudi RK, Kumar R. Upstream determinants of estrogen receptor-alpha regulation of metastatic tumor antigen 3 pathway. J Biol Chem. 2004 Jul 30; 279(31):32709-15. PMID: 15169784.
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    24. Kljuic A, Bazzi H, Sundberg JP, Martinez-Mir A, O'Shaughnessy R, Mahoney MG, Levy M, Montagutelli X, Ahmad W, Aita VM, Gordon D, Uitto J, Whiting D, Ott J, Fischer S, Gilliam TC, Jahoda CA, Morris RJ, Panteleyev AA, Nguyen VT, Christiano AM. Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired pemphigus vulgaris. Cell. 2003 Apr 18; 113(2):249-60. PMID: 12705872.
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    25. Pulkkinen L, Choi YW, Simpson A, Montagutelli X, Sundberg J, Uitto J, Mahoney MG. Loss of cell adhesion in Dsg3bal-Pas mice with homozygous deletion mutation (2079del14) in the desmoglein 3 gene. J Invest Dermatol. 2002 Dec; 119(6):1237-43. PMID: 12485423.
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    26. Mahoney MG, Simpson A, Aho S, Uitto J, Pulkkinen L. Interspecies conservation and differential expression of mouse desmoglein gene family. Exp Dermatol. 2002 Apr; 11(2):115-25. PMID: 11994138.
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    27. Mahoney MG, Simpson A, Jost M, Noé M, Kari C, Pepe D, Choi YW, Uitto J, Rodeck U. Metastasis-associated protein (MTA)1 enhances migration, invasion, and anchorage-independent survival of immortalized human keratinocytes. Oncogene. 2002 Mar 28; 21(14):2161-70. PMID: 11948399.
      Citations:    
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