Robert Allen Sikes

TitleAssociate Professor
InstitutionUniversity of Delaware
DepartmentBiological Sciences
Address105 The Green
Newark DE 19716
Phone302-831-6050
vCardDownload vCard

    Collapse Research 
    Collapse research activities and funding
    R01DK063919     (SIKES, ROBERT A)Jul 22, 2002 - Jun 30, 2007
    NIH
    Tracking Urogenital Sinus Cell Progeny
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lertsuwan K, Choe LH, Marwa IR, Lee K, Sikes RA. Identification of Fibulin-1 as a Human Bone Marrow Stromal (HS-5) Cell-Derived Factor That Induces Human Prostate Cancer Cell Death. Prostate. 2017 May; 77(7):729-742. PMID: 28168724.
      Citations:    
    2. Lertsuwan K, Peters W, Johnson L, Lertsuwan J, Marwa I, Sikes RA. Purinergic Receptor Expression and Cellular Responses to Purinergic Agonists in Human Prostate Cancer Cells. Anticancer Res. 2017 02; 37(2):529-537. PMID: 28179298.
      Citations:    
    3. Miles FL, Kurtoglu S, Ahmer C, Soori M, Favate JS, Sikes RA. Transforming growth factor-ß signaling induced during prostate cancer cell death and neuroendocrine differentiation is mediated by bone marrow stromal cells. Prostate. 2015 Nov; 75(15):1802-13. PMID: 26392321.
      Citations:    
    4. Miles FL, Lynch JE, Sikes RA. Cell-based assays using calcein acetoxymethyl ester show variation in fluorescence with treatment conditions. J Biol Methods. 2015; 2(3). PMID: 26937420.
      Citations:    
    5. Jansson KH, Castillo DG, Morris JW, Boggs ME, Czymmek KJ, Adams EL, Schramm LP, Sikes RA. Identification of Beta-2 as a Key Cell Adhesion Molecule in PCa Cell Neurotropic Behavior: A Novel Ex Vivo and Biophysical Approach. PLoS One. 2014; 9(6):e98408. PMID: 24892658.
      Citations:    
    6. Miles FL, Sikes RA. Insidious changes in stromal matrix fuel cancer progression. Mol Cancer Res. 2014 Mar; 12(3):297-312. PMID: 24452359.
      Citations:    
    7. Dong X, Xu W, Sikes RA, Wu C. Combination of low dose of genistein and daidzein has synergistic preventive effects on isogenic human prostate cancer cells when compared with individual soy isoflavone. Food Chem. 2013 Dec 1; 141(3):1923-33. PMID: 23870911.
      Citations:    
    8. Dong X, Xu W, Sikes RA, Wu C. Apoptotic effects of cooked and in vitro digested soy on human prostate cancer cells. Food Chem. 2012 Dec 1; 135(3):1643-52. PMID: 22953905.
      Citations:    
    9. Hillyer RL, Sirinvasin P, Joglekar M, Sikes RA, van Golen KL, Nohe A. Differential effects of vitamin D treatment on inflammatory and non-inflammatory breast cancer cell lines. Clin Exp Metastasis. 2012 Dec; 29(8):971-9. PMID: 22610818.
      Citations:    
    10. Miles FL, Tung NS, Aguiar AA, Kurtoglu S, Sikes RA. Increased TGF-ß1-mediated suppression of growth and motility in castrate-resistant prostate cancer cells is consistent with Smad2/3 signaling. Prostate. 2012 Sep 1; 72(12):1339-50. PMID: 22228025.
      Citations:    
    11. Jansson KH, Lynch JE, Lepori-Bui N, Czymmek KJ, Duncan RL, Sikes RA. Overexpression of the VSSC-associated CAM, ß-2, enhances LNCaP cell metastasis associated behavior. Prostate. 2012 Jul 1; 72(10):1080-92. PMID: 22127840.
      Citations:    
    12. Kuczmarski JM, Darocki MD, DuPont JJ, Sikes RA, Cooper CR, Farquhar WB, Edwards DG. Effect of moderate-to-severe chronic kidney disease on flow-mediated dilation and progenitor cells. Exp Biol Med (Maywood). 2011 Sep 1; 236(9):1085-92. PMID: 21791552.
      Citations:    
    13. Zhang C, Soori M, Miles FL, Sikes RA, Carson DD, Chung LW, Farach-Carson MC. Paracrine factors produced by bone marrow stromal cells induce apoptosis and neuroendocrine differentiation in prostate cancer cells. Prostate. 2011 Feb 1; 71(2):157-67. PMID: 20665531.
      Citations:    
    14. Li Y, Sikes RA, Malaeb BS, Yeung F, Law A, Graham SE, Pei M, Kao C, Nelson J, Koeneman KS, Chung LW. Osteoblasts can stimulate prostate cancer growth and transcriptionally down-regulate PSA expression in cell line models. Urol Oncol. 2011 Nov-Dec; 29(6):802-8. PMID: 20451417.
      Citations:    
    15. Chen Q, DeGraff DJ, Sikes RA. The developmental expression profile of PAX2 in the murine prostate. Prostate. 2010 May 1; 70(6):654-65. PMID: 20017165.
      Citations:    
    16. Degraff DJ, Aguiar AA, Chen Q, Adams LK, Williams BJ, Sikes RA. Androgen mediated translational and postranslational regulation of IGFBP-2 in androgen-sensitive LNCaP human prostate cancer cells. Am J Transl Res. 2010; 2(2):200-8. PMID: 20407609.
      Citations:    
    17. Sheehan S, Muthusamy A, Paul E, Sikes RA, Gomes RR. Short-term intermittent PTH 1-34 administration enhances bone formation in SCID/Beige mice. Endocr J. 2010; 57(5):373-82. PMID: 20139633.
      Citations:    
    18. Thalmann GN, Rhee H, Sikes RA, Pathak S, Multani A, Zhau HE, Marshall FF, Chung LW. Human prostate fibroblasts induce growth and confer castration resistance and metastatic potential in LNCaP Cells. Eur Urol. 2010 Jul; 58(1):162-71. PMID: 19747763.
      Citations:    
    19. Gomes RR, Buttke P, Paul EM, Sikes RA. Osteosclerotic prostate cancer metastasis to murine bone are enhanced with increased bone formation. Clin Exp Metastasis. 2009; 26(7):641-51. PMID: 19421879.
      Citations:    
    20. Chung SW, Miles FL, Sikes RA, Cooper CR, Farach-Carson MC, Ogunnaike BA. Quantitative modeling and analysis of the transforming growth factor beta signaling pathway. Biophys J. 2009 Mar 4; 96(5):1733-50. PMID: 19254534.
      Citations:    
    21. Pritchard C, Mecham B, Dumpit R, Coleman I, Bhattacharjee M, Chen Q, Sikes RA, Nelson PS. Conserved gene expression programs integrate mammalian prostate development and tumorigenesis. Cancer Res. 2009 Mar 1; 69(5):1739-47. PMID: 19223557.
      Citations:    
    22. Degraff DJ, Aguiar AA, Sikes RA. Disease evidence for IGFBP-2 as a key player in prostate cancer progression and development of osteosclerotic lesions. Am J Transl Res. 2009; 1(2):115-30. PMID: 19956425.
      Citations:    
    23. Cooper CR, Graves B, Pruitt F, Chaib H, Lynch JE, Cox AK, Sequeria L, van Golen KL, Evans A, Czymmek K, Bullard RS, Donald CD, Sol-Church K, Gendernalik JD, Weksler B, Farach-Carson MC, Macoska JA, Sikes RA, Pienta KJ. Novel surface expression of reticulocalbin 1 on bone endothelial cells and human prostate cancer cells is regulated by TNF-alpha. J Cell Biochem. 2008 Aug 15; 104(6):2298-309. PMID: 18561328.
      Citations:    
    24. Degraff DJ, Malik M, Chen Q, Miyako K, Rejto L, Aguiar AA, Bancroft DR, Cohen P, Sikes RA. Hormonal regulation of IGFBP-2 proteolysis is attenuated with progression to androgen insensitivity in the LNCaP progression model. J Cell Physiol. 2007 Oct; 213(1):261-8. PMID: 17492783.
      Citations:    
    25. Deeble PD, Cox ME, Frierson HF, Sikes RA, Palmer JB, Davidson RJ, Casarez EV, Amorino GP, Parsons SJ. Androgen-independent growth and tumorigenesis of prostate cancer cells are enhanced by the presence of PKA-differentiated neuroendocrine cells. Cancer Res. 2007 Apr 15; 67(8):3663-72. PMID: 17440078.
      Citations:    
    26. Fiske JL, Fomin VP, Brown ML, Duncan RL, Sikes RA. Voltage-sensitive ion channels and cancer. Cancer Metastasis Rev. 2006 Sep; 25(3):493-500. PMID: 17111226.
      Citations:    
    27. Tate A, Isotani S, Bradley MJ, Sikes RA, Davis R, Chung LW, Edlund M. Met-Independent Hepatocyte Growth Factor-mediated regulation of cell adhesion in human prostate cancer cells. BMC Cancer. 2006; 6:197. PMID: 16869958.
      Citations:    
    28. Chen Q, Watson JT, Marengo SR, Decker KS, Coleman I, Nelson PS, Sikes RA. Gene expression in the LNCaP human prostate cancer progression model: progression associated expression in vitro corresponds to expression changes associated with prostate cancer progression in vivo. Cancer Lett. 2006 Dec 8; 244(2):274-88. PMID: 16500022.
      Citations:    
    29. Krueckl SL, Sikes RA, Edlund NM, Bell RH, Hurtado-Coll A, Fazli L, Gleave ME, Cox ME. Increased insulin-like growth factor I receptor expression and signaling are components of androgen-independent progression in a lineage-derived prostate cancer progression model. Cancer Res. 2004 Dec 1; 64(23):8620-9. PMID: 15574769.
      Citations:    
    30. Sikes RA, Nicholson BE, Koeneman KS, Edlund NM, Bissonette EA, Bradley MJ, Thalmann GN, Cecchini MG, Pienta KJ, Chung LW. Cellular interactions in the tropism of prostate cancer to bone. Int J Cancer. 2004 Jul 1; 110(4):497-503. PMID: 15122581.
      Citations:    
    31. Brennen WN, Cooper CR, Capitosti S, Brown ML, Sikes RA. Thalidomide and analogues: current proposed mechanisms and therapeutic usage. Clin Prostate Cancer. 2004 Jun; 3(1):54-61. PMID: 15279692.
      Citations:    
    32. Stewart DA, Cooper CR, Sikes RA. Changes in extracellular matrix (ECM) and ECM-associated proteins in the metastatic progression of prostate cancer. Reprod Biol Endocrinol. 2004 Jan 7; 2:2. PMID: 14711377.
      Citations:    
    33. Cooper CR, Sikes RA, Nicholson BE, Sun YX, Pienta KJ, Taichman RS. Cancer cells homing to bone: the significance of chemotaxis and cell adhesion. Cancer Treat Res. 2004; 118:291-309. PMID: 15043197.
      Citations:    
    34. Sikes RA, Walls AM, Brennen WN, Anderson JD, Choudhury-Mukherjee I, Schenck HA, Brown ML. Therapeutic approaches targeting prostate cancer progression using novel voltage-gated ion channel blockers. Clin Prostate Cancer. 2003 Dec; 2(3):181-7. PMID: 15040863.
      Citations:    
    35. Abbott DE, Pritchard C, Clegg NJ, Ferguson C, Dumpit R, Sikes RA, Nelson PS. Expressed sequence tag profiling identifies developmental and anatomic partitioning of gene expression in the mouse prostate. Genome Biol. 2003; 4(12):R79. PMID: 14659016.
      Citations:    
    36. Anderson JD, Hansen TP, Lenkowski PW, Walls AM, Choudhury IM, Schenck HA, Friehling M, Höll GM, Patel MK, Sikes RA, Brown ML. Voltage-gated sodium channel blockers as cytostatic inhibitors of the androgen-independent prostate cancer cell line PC-3. Mol Cancer Ther. 2003 Nov; 2(11):1149-54. PMID: 14617788.
      Citations:    
    37. Tennant MK, Vessella RL, Sprenger CC, Sikes RA, Hwa V, Baker LD, Plymate SR. Insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1/mac 25) is reduced in human prostate cancer and is inversely related to tumor volume and proliferation index in Lucap 23.12 xenografts. Prostate. 2003 Jul 1; 56(2):115-22. PMID: 12746836.
      Citations:    
    38. Bakin RE, Gioeli D, Sikes RA, Bissonette EA, Weber MJ. Constitutive activation of the Ras/mitogen-activated protein kinase signaling pathway promotes androgen hypersensitivity in LNCaP prostate cancer cells. Cancer Res. 2003 Apr 15; 63(8):1981-9. PMID: 12702592.
      Citations:    
    39. Guo N, Ye JJ, Liang SJ, Mineo R, Li SL, Giannini S, Plymate SR, Sikes RA, Fujita-Yamaguchi Y. The role of insulin-like growth factor-II in cancer growth and progression evidenced by the use of ribozymes and prostate cancer progression models. Growth Horm IGF Res. 2003 Feb; 13(1):44-53. PMID: 12550081.
      Citations:    
    40. Edlund M, Miyamoto T, Sikes RA, Ogle R, Laurie GW, Farach-Carson MC, Otey CA, Zhau HE, Chung LW. Integrin expression and usage by prostate cancer cell lines on laminin substrata. Cell Growth Differ. 2001 Feb; 12(2):99-107. PMID: 11243469.
      Citations:    
    41. Thalmann GN, Sikes RA, Wu TT, Degeorges A, Chang SM, Ozen M, Pathak S, Chung LW. LNCaP progression model of human prostate cancer: androgen-independence and osseous metastasis. Prostate. 2000 Jul 1; 44(2):91-103 Jul 1;44(2). PMID: 10881018.
      Citations:    
    42. Degeorges A, Wang F, Frierson HF, Seth A, Sikes RA. Distribution of IGFBP-rP1 in normal human tissues. J Histochem Cytochem. 2000 Jun; 48(6):747-54. PMID: 10820148.
      Citations:    
    43. Hyytinen ER, Frierson HF, Sipe TW, Li CL, Degeorges A, Sikes RA, Chung LW, Dong JT. Loss of heterozygosity and lack of mutations of the XPG/ERCC5 DNA repair gene at 13q33 in prostate cancer. Prostate. 1999 Nov 1; 41(3):190-5. PMID: 10517877.
      Citations:    
    44. Thalmann GN, Sikes RA, Devoll RE, Kiefer JA, Markwalder R, Klima I, Farach-Carson CM, Studer UE, Chung LW. Osteopontin: possible role in prostate cancer progression. Clin Cancer Res. 1999 Aug; 5(8):2271-7. PMID: 10473115.
      Citations:    
    45. Degeorges A, Wang F, Frierson HF, Seth A, Chung LW, Sikes RA. Human prostate cancer expresses the low affinity insulin-like growth factor binding protein IGFBP-rP1. Cancer Res. 1999 Jun 15; 59(12):2787-90. PMID: 10383131.
      Citations:    
    46. Theodorescu D, Frierson HF, Sikes RA. Molecular determination of surgical margins using fossa biopsies at radical prostatectomy. J Urol. 1999 May; 161(5):1442-8. PMID: 10210369.
      Citations:    
    47. Vafa A, Zhang Y, Sikes RA, Marengo SR. Overexpression of p185erbB2/neu in the NbE prostatic epithelial cell line increases cellular spreading and the expression of integrin alpha6beta1. Int J Oncol. 1998 Dec; 13(6):1191-7. PMID: 9824630.
      Citations:    
    48. Wu TT, Sikes RA, Cui Q, Thalmann GN, Kao C, Murphy CF, Yang H, Zhau HE, Balian G, Chung LW. Establishing human prostate cancer cell xenografts in bone: induction of osteoblastic reaction by prostate-specific antigen-producing tumors in athymic and SCID/bg mice using LNCaP and lineage-derived metastatic sublines. Int J Cancer. 1998 Sep 11; 77(6):887-94. PMID: 9714059.
      Citations:    
    49. Chen ME, Lin SH, Chung LW, Sikes RA. Isolation and characterization of PAGE-1 and GAGE-7. New genes expressed in the LNCaP prostate cancer progression model that share homology with melanoma-associated antigens. J Biol Chem. 1998 Jul 10; 273(28):17618-25. PMID: 9651357.
      Citations:    
    50. Chung LW, Kao C, Sikes RA, Zhau HE. Human prostate cancer progression models and therapeutic intervention. Hinyokika Kiyo. 1997 Nov; 43(11):815-20. PMID: 9436028.
      Citations:    
    51. Cleutjens KB, van der Korput HA, Ehren-van Eekelen CC, Sikes RA, Fasciana C, Chung LW, Trapman J. A 6-kb promoter fragment mimics in transgenic mice the prostate-specific and androgen-regulated expression of the endogenous prostate-specific antigen gene in humans. Mol Endocrinol. 1997 Aug; 11(9):1256-65. PMID: 9259317.
      Citations:    
    52. Marengo SR, Sikes RA, Anezinis P, Chang SM, Chung LW. Metastasis induced by overexpression of p185neu-T after orthotopic injection into a prostatic epithelial cell line (NbE). Mol Carcinog. 1997 Jul; 19(3):165-75. PMID: 9254883.
      Citations:    
    53. Ko SC, Cheon J, Kao C, Gotoh A, Shirakawa T, Sikes RA, Karsenty G, Chung LW. Osteocalcin promoter-based toxic gene therapy for the treatment of osteosarcoma in experimental models. Cancer Res. 1996 Oct 15; 56(20):4614-9. PMID: 8840973.
      Citations:    
    54. Thalmann GN, Sikes RA, Chang SM, Johnston DA, von Eschenbach AC, Chung LW. Suramin-induced decrease in prostate-specific antigen expression with no effect on tumor growth in the LNCaP model of human prostate cancer. J Natl Cancer Inst. 1996 Jun 19; 88(12):794-801. PMID: 8637045.
      Citations:    
    55. Zhau HY, Zhou J, Symmans WF, Chen BQ, Chang SM, Sikes RA, Chung LW. Transfected neu oncogene induces human prostate cancer metastasis. Prostate. 1996 Feb; 28(2):73-83. PMID: 8604395.
      Citations:    
    56. He XY, Sikes RA, Thomsen S, Chung LW, Jacques SL. Photodynamic therapy with photofrin II induces programmed cell death in carcinoma cell lines. Photochem Photobiol. 1994 Apr; 59(4):468-73. PMID: 8022890.
      Citations:    
    57. Sikes RA, Chung LW. Acquisition of a tumorigenic phenotype by a rat ventral prostate epithelial cell line expressing a transfected activated neu oncogene. Cancer Res. 1992 Jun 1; 52(11):3174-81. PMID: 1350510.
      Citations:    
    58. Chung LW, Li W, Gleave ME, Hsieh JT, Wu HC, Sikes RA, Zhau HE, Bandyk MG, Logothetis CJ, Rubin JS, et al. Human prostate cancer model: roles of growth factors and extracellular matrices. J Cell Biochem Suppl. 1992; 16H:99-105. PMID: 1289680.
      Citations:    
    59. Sikes RA, Thomsen S, Petrow V, Neubauer BL, Chung LW. Inhibition of experimentally induced mouse prostatic hyperplasia by castration or steroid antagonist administration. Biol Reprod. 1990 Aug; 43(2):353-62. PMID: 1696141.
      Citations:    
    Sikes's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (281)
    Explore
    _
    Co-Authors (8)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _
    Physical Neighbors
    _