Thomas Jefferson University

Philip Wedegaertner

TitleProfessor
InstitutionThomas Jefferson University
DepartmentBiochem & Molecular Biology
Address233 S. 10th Street
Philadelphia PA 19107
Phone215-503-3137
vCardDownload vCard

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Dwyer MB, Aumiller JL, Wedegaertner PB. Going rogue: mechanisms, regulation, and roles of mutationally activated Ga in human cancer. Mol Pharmacol. 2024 Aug 26. PMID: 39187387.
      Citations:    
    2. Han A, Mukha D, Chua V, Purwin TJ, Tiago M, Modasia B, Baqai U, Aumiller JL, Bechtel N, Hunter E, Danielson M, Terai M, Wedegaertner PB, Sato T, Landreville S, Davies MA, Kurtenbach S, Harbour JW, Schug ZT, Aplin AE. Co-Targeting FASN and mTOR Suppresses Uveal Melanoma Growth. Cancers (Basel). 2023 Jun 30; 15(13). PMID: 37444561.
      Citations:    
    3. Rajanala K, Wedegaertner PB. G?? signaling regulates microtubule-dependent control of Golgi integrity. Cell Signal. 2023 Feb 16; 106:110630. PMID: 36805843.
      Citations:    
    4. Aumiller JL, Wedegaertner PB. Disruption of the interaction between mutationally activated Gaq and G?? attenuates aberrant signaling. J Biol Chem. 2023 Jan 07; 299(2):102880. PMID: 36626984.
      Citations:    
    5. Randolph CE, Dwyer MB, Aumiller JL, Dixon AJ, Inoue A, Osei-Owusu P, Wedegaertner PB. Enhanced membrane binding of oncogenic G protein aqQ209L confers resistance to inhibitor YM-254890. J Biol Chem. 2022 11; 298(11):102538. PMID: 36174676.
      Citations:    
    6. Terai M, Shimada A, Chervoneva I, Hulse L, Danielson M, Swensen J, Orloff M, Wedegaertner PB, Benovic JL, Aplin AE, Sato T. Prognostic Values of G-Protein Mutations in Metastatic Uveal Melanoma. Cancers (Basel). 2021 Nov 17; 13(22). PMID: 34830903.
      Citations:    
    7. Rajanala K, Klayman LM, Wedegaertner PB. Gß? regulates mitotic Golgi fragmentation and G2/M cell cycle progression. Mol Biol Cell. 2021 10 01; 32(20):br2. PMID: 34260268.
      Citations:    
    8. Lapadula D, Farias E, Randolph CE, Purwin T, McGrath D, Charpentier T, Zhang L, Wu S, Terai M, Sato T, Tall GG, Zhou N, Wedegaertner P, Aplin AE, Aguirre-Ghiso J, Benovic JL. Effects of Oncogenic Gaq and Ga11 Inhibition by FR900359 in Uveal Melanoma. Mol Cancer Res. 2018 Dec 19. PMID: 30567972.
      Citations:    
    9. Xiao P, Huang X, Huang L, Yang J, Li A, Shen K, Wedegaertner PB, Jiang X. G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. Exp Cell Res. 2017 11 15; 360(2):273-280. PMID: 28912086.
      Citations:    
    10. Irannejad R, Pessino V, Mika D, Huang B, Wedegaertner PB, Conti M, von Zastrow M. Functional selectivity of GPCR-directed drug action through location bias. Nat Chem Biol. 2017 Jul; 13(7):799-806. PMID: 28553949.
      Citations:    
    11. Chua V, Lapadula D, Randolph C, Benovic JL, Wedegaertner PB, Aplin AE. Dysregulated GPCR Signaling and Therapeutic Options in Uveal Melanoma. Mol Cancer Res. 2017 May; 15(5):501-506. PMID: 28223438.
      Citations:    
    12. Klayman LM, Wedegaertner PB. Inducible Inhibition of Gß? Reveals Localization-dependent Functions at the Plasma Membrane and Golgi. J Biol Chem. 2017 Feb 03; 292(5):1773-1784. PMID: 27994056.
      Citations:    
    13. Helms MC, Grabocka E, Martz MK, Fischer CC, Suzuki N, Wedegaertner PB. Mitotic-dependent phosphorylation of leukemia-associated RhoGEF (LARG) by Cdk1. Cell Signal. 2016 Jan; 28(1):43-52. PMID: 26483157.
      Citations:    
    14. Hewavitharana T, Wedegaertner PB. PAQR3 regulates Golgi vesicle fission and transport via the Gß?-PKD signaling pathway. Cell Signal. 2015 Dec; 27(12):2444-51. PMID: 26327583.
      Citations:    
    15. Malik S, deRubio RG, Trembley M, Irannejad R, Wedegaertner PB, Smrcka AV. G protein ß? subunits regulate cardiomyocyte hypertrophy through a perinuclear Golgi phosphatidylinositol 4-phosphate hydrolysis pathway. Mol Biol Cell. 2015 Mar 15; 26(6):1188-98. PMID: 25609085.
      Citations:    
    16. Xu H, Jiang X, Shen K, Fischer CC, Wedegaertner PB. The regulator of G protein signaling (RGS) domain of G protein-coupled receptor kinase 5 (GRK5) regulates plasma membrane localization and function. Mol Biol Cell. 2014 Jul 1; 25(13):2105-15. PMID: 24807909.
      Citations:    
    17. Martz MK, Grabocka E, Beeharry N, Yen TJ, Wedegaertner PB. Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in cytokinesis and required for the proper completion of abscission. Mol Biol Cell. 2013 Sep; 24(18):2785-94. PMID: 23885121.
      Citations:    
    18. Wedegaertner PB. G protein trafficking. Subcell Biochem. 2012; 63:193-223. PMID: 23161140.
      Citations:    
    19. Hewavitharana T, Wedegaertner PB. Non-canonical signaling and localizations of heterotrimeric G proteins. Cell Signal. 2012 Jan; 24(1):25-34. PMID: 21907280.
      Citations:    
    20. Irannejad R, Wedegaertner PB. Regulation of constitutive cargo transport from the trans-Golgi network to plasma membrane by Golgi-localized G protein betagamma subunits. J Biol Chem. 2010 Oct 15; 285(42):32393-404. PMID: 20720014.
      Citations:    
    21. Crouthamel M, Abankwa D, Zhang L, DiLizio C, Manning DR, Hancock JF, Wedegaertner PB. An N-terminal polybasic motif of Gaq is required for signaling and influences membrane nanodomain distribution. Mol Pharmacol. 2010 Oct; 78(4):767-77. PMID: 20664004.
      Citations:    
    22. Banerjee J, Fischer CC, Wedegaertner PB. The amino acid motif L/IIxxFE defines a novel actin-binding sequence in PDZ-RhoGEF. Biochemistry. 2009 Aug 25; 48(33):8032-43. PMID: 19618964.
      Citations:    
    23. Bhattacharyya R, Banerjee J, Khalili K, Wedegaertner PB. Differences in Galpha12- and Galpha13-mediated plasma membrane recruitment of p115-RhoGEF. Cell Signal. 2009 Jun; 21(6):996-1006. PMID: 19249348.
      Citations:    
    24. Crouthamel M, Thiyagarajan MM, Evanko DS, Wedegaertner PB. N-terminal polybasic motifs are required for plasma membrane localization of Galpha(s) and Galpha(q). Cell Signal. 2008 Oct; 20(10):1900-10. PMID: 18647648.
      Citations:    
    25. Iwanicki MP, Vomastek T, Tilghman RW, Martin KH, Banerjee J, Wedegaertner PB, Parsons JT. FAK, PDZ-RhoGEF and ROCKII cooperate to regulate adhesion movement and trailing-edge retraction in fibroblasts. J Cell Sci. 2008 Mar 15; 121(Pt 6):895-905. PMID: 18303050.
      Citations:    
    26. Grabocka E, Wedegaertner PB. Disruption of oligomerization induces nucleocytoplasmic shuttling of leukemia-associated rho Guanine-nucleotide exchange factor. Mol Pharmacol. 2007 Oct; 72(4):993-1002. PMID: 17609419.
      Citations:    
    27. Marrari Y, Crouthamel M, Irannejad R, Wedegaertner PB. Assembly and trafficking of heterotrimeric G proteins. Biochemistry. 2007 Jul 3; 46(26):7665-77. PMID: 17559193.
      Citations:    
    28. Jiang X, Benovic JL, Wedegaertner PB. Plasma membrane and nuclear localization of G protein coupled receptor kinase 6A. Mol Biol Cell. 2007 Aug; 18(8):2960-9. PMID: 17538017.
      Citations:    
    29. Escribá PV, Wedegaertner PB, Goñi FM, Vögler O. Lipid-protein interactions in GPCR-associated signaling. Biochim Biophys Acta. 2007 Apr; 1768(4):836-52. PMID: 17067547.
      Citations:    
    30. Billington CK, Kong KC, Bhattacharyya R, Wedegaertner PB, Panettieri RA, Chan TO, Penn RB. Cooperative regulation of p70S6 kinase by receptor tyrosine kinases and G protein-coupled receptors augments airway smooth muscle growth. Biochemistry. 2005 Nov 8; 44(44):14595-605. PMID: 16262259.
      Citations:    
    31. Grabocka E, Wedegaertner PB. Functional consequences of G alpha 13 mutations that disrupt interaction with p115RhoGEF. Oncogene. 2005 Mar 24; 24(13):2155-65. PMID: 15735747.
      Citations:    
    32. Evanko DS, Thiyagarajan MM, Takida S, Wedegaertner PB. Loss of association between activated Galpha q and Gbetagamma disrupts receptor-dependent and receptor-independent signaling. Cell Signal. 2005 Oct; 17(10):1218-28. PMID: 16038796.
      Citations:    
    33. Cui J, Holgado-Madruga M, Su W, Tsuiki H, Wedegaertner P, Wong AJ. Identification of a specific domain responsible for JNK2alpha2 autophosphorylation. J Biol Chem. 2005 Mar 18; 280(11):9913-20. PMID: 15637069.
      Citations:    
    34. Takida S, Fischer CC, Wedegaertner PB. Palmitoylation and plasma membrane targeting of RGS7 are promoted by alpha o. Mol Pharmacol. 2005 Jan; 67(1):132-9. PMID: 15496508.
      Citations:    
    35. Day PW, Tesmer JJ, Sterne-Marr R, Freeman LC, Benovic JL, Wedegaertner PB. Characterization of the GRK2 binding site of Galphaq. J Biol Chem. 2004 Dec 17; 279(51):53643-52. PMID: 15471870.
      Citations:    
    36. Takida S, Wedegaertner PB. Exocytic pathway-independent plasma membrane targeting of heterotrimeric G proteins. FEBS Lett. 2004 Jun 4; 567(2-3):209-13. PMID: 15178324.
      Citations:    
    37. Thiyagarajan MM, Stracquatanio RP, Pronin AN, Evanko DS, Benovic JL, Wedegaertner PB. A predicted amphipathic helix mediates plasma membrane localization of GRK5. J Biol Chem. 2004 Apr 23; 279(17):17989-95. PMID: 14976207.
      Citations:    
    38. Banerjee J, Wedegaertner PB. Identification of a novel sequence in PDZ-RhoGEF that mediates interaction with the actin cytoskeleton. Mol Biol Cell. 2004 Apr; 15(4):1760-75. PMID: 14742719.
      Citations:    
    39. Day PW, Wedegaertner PB, Benovic JL. Analysis of G-protein-coupled receptor kinase RGS homology domains. Methods Enzymol. 2004; 390:295-310. PMID: 15488185.
      Citations:    
    40. Day PW, Carman CV, Sterne-Marr R, Benovic JL, Wedegaertner PB. Differential interaction of GRK2 with members of the G alpha q family. Biochemistry. 2003 Aug 5; 42(30):9176-84. PMID: 12885252.
      Citations:    
    41. Bhattacharyya R, Wedegaertner PB. Characterization of G alpha 13-dependent plasma membrane recruitment of p115RhoGEF. Biochem J. 2003 May 1; 371(Pt 3):709-20. PMID: 12534370.
      Citations:    
    42. Bhattacharyya R, Wedegaertner PB. Mutation of an N-terminal acidic-rich region of p115-RhoGEF dissociates alpha13 binding and alpha13-promoted plasma membrane recruitment. FEBS Lett. 2003 Apr 10; 540(1-3):211-6. PMID: 12681510.
      Citations:    
    43. Takida S, Wedegaertner PB. Heterotrimer formation, together with isoprenylation, is required for plasma membrane targeting of Gbetagamma. J Biol Chem. 2003 May 9; 278(19):17284-90. PMID: 12609996.
      Citations:    
    44. Sterne-Marr R, Tesmer JJ, Day PW, Stracquatanio RP, Cilente JA, O'Connor KE, Pronin AN, Benovic JL, Wedegaertner PB. G protein-coupled receptor Kinase 2/G alpha q/11 interaction. A novel surface on a regulator of G protein signaling homology domain for binding G alpha subunits. J Biol Chem. 2003 Feb 21; 278(8):6050-8. PMID: 12427730.
      Citations:    
    45. Thiyagarajan MM, Bigras E, Van Tol HH, Hébert TE, Evanko DS, Wedegaertner PB. Activation-induced subcellular redistribution of G alpha(s) is dependent upon its unique N-terminus. Biochemistry. 2002 Jul 30; 41(30):9470-84. PMID: 12135370.
      Citations:    
    46. Wedegaertner PB. Characterization of subcellular localization and stability of a splice variant of G alpha i2. BMC Cell Biol. 2002 May 31; 3:12. PMID: 12057015.
      Citations:    
    47. Evanko DS, Thiyagarajan MM, Siderovski DP, Wedegaertner PB. Gbeta gamma isoforms selectively rescue plasma membrane localization and palmitoylation of mutant Galphas and Galphaq. J Biol Chem. 2001 Jun 29; 276(26):23945-53. PMID: 11294873.
      Citations:    
    48. Bhattacharyya R, Wedegaertner PB. Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding. J Biol Chem. 2000 May 19; 275(20):14992-9. PMID: 10747909.
      Citations:    
    49. Evanko DS, Thiyagarajan MM, Wedegaertner PB. Interaction with Gbetagamma is required for membrane targeting and palmitoylation of Galpha(s) and Galpha(q). J Biol Chem. 2000 Jan 14; 275(2):1327-36. PMID: 10625681.
      Citations:    
    50. Carman CV, Parent JL, Day PW, Pronin AN, Sternweis PM, Wedegaertner PB, Gilman AG, Benovic JL, Kozasa T. Selective regulation of Galpha(q/11) by an RGS domain in the G protein-coupled receptor kinase, GRK2. J Biol Chem. 1999 Nov 26; 274(48):34483-92. PMID: 10567430.
      Citations:    
    51. Wedegaertner PB. Lipid modifications and membrane targeting of G alpha. Biol Signals Recept. 1998 Mar-Apr; 7(2):125-35. PMID: 9629464.
      Citations:    
    52. Iiri T, Backlund PS, Jones TL, Wedegaertner PB, Bourne HR. Reciprocal regulation of Gs alpha by palmitate and the beta gamma subunit. Proc Natl Acad Sci U S A. 1996 Dec 10; 93(25):14592-7. PMID: 8962097.
      Citations:    
    53. Wedegaertner PB, Bourne HR, von Zastrow M. Activation-induced subcellular redistribution of Gs alpha. Mol Biol Cell. 1996 Aug; 7(8):1225-33. PMID: 8856666.
      Citations:    
    54. Wedegaertner PB, Bourne HR. Activation and depalmitoylation of Gs alpha. Cell. 1994 Jul 1; 77(7):1063-70. PMID: 7912657.
      Citations:    
    55. Wedegaertner PB, Chu DH, Wilson PT, Levis MJ, Bourne HR. Palmitoylation is required for signaling functions and membrane attachment of Gq alpha and Gs alpha. J Biol Chem. 1993 Nov 25; 268(33):25001-8. PMID: 8227063.
      Citations:    
    56. Wedegaertner PB, Gill GN. Effect of carboxyl terminal truncation on the tyrosine kinase activity of the epidermal growth factor receptor. Arch Biochem Biophys. 1992 Jan; 292(1):273-80. PMID: 1309297.
      Citations:    
    57. Nishibe S, Wahl MI, Wedegaertner PB, Kim JW, Rhee SG, Carpenter G, Kim JJ. Selectivity of phospholipase C phosphorylation by the epidermal growth factor receptor, the insulin receptor, and their cytoplasmic domains. Proc Natl Acad Sci U S A. 1990 Jan; 87(1):424-8. PMID: 2153302.
      Citations:    
    58. Wedegaertner PB, Gill GN. Activation of the purified protein tyrosine kinase domain of the epidermal growth factor receptor. J Biol Chem. 1989 Jul 5; 264(19):11346-53. PMID: 2661557.
      Citations:    
    Wedegaertner's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (230)
    Explore
    _
    Co-Authors (11)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _
    Physical Neighbors
    _