Paul Bray

TitleProfessor
InstitutionThomas Jefferson University
DepartmentHematology
Address1015 Walnut St.
Philadelphia PA 19107
Phone215-955-7786
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    Collapse Overview 
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    Dr. Bray has had continuous funding from the National Institutes of Health (NIH) since 1986.

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    K11HL001815     (BRAY, PAUL F.)Jul 1, 1986 - Jun 30, 1991
    NIH
    BIOSYNTHESIS NAD STRUCTURE OF THE FIBRINOGEN RECEPTOR
    Role: Principal Investigator

    R29HL043020     (BRAY, PAUL F.)Jul 1, 1989 - Aug 31, 1994
    NIH
    CELLULAR CONSEQUENCES OF DEFECTIVE IIB AND IIIA GENES
    Role: Principal Investigator

    R01HL051457     (BRAY, PAUL F.)Feb 1, 1994 - Jan 31, 1998
    NIH
    IN VITRO AND EX VIVO STUDIES ON MEGAKARYOCYTOPOIESIS
    Role: Principal Investigator

    R01HL057488     (BRAY, PAUL F.)Jan 1, 1997 - Dec 31, 2002
    NIH
    PLATELET P1A2--STUDIES ON A PRO THROMBOTIC POLYMORPHISM
    Role: Principal Investigator

    R01HL058564     (BRAY, PAUL F.)Aug 1, 1997 - Jul 31, 2001
    NIH
    MECHANISMS OF ARTERIAL THROMBOSIS IN WOMEN
    Role: Principal Investigator

    R01HL065229     (BRAY, PAUL F.)Aug 1, 2000 - Jul 31, 2007
    NIH
    GENETIC BASIS OF PLATELET HYPERFUNCTION
    Role: Principal Investigator

    P50HL065967     (BRAY, PAUL F.)Jun 6, 2001 - Jan 31, 2007
    NIH
    PLATELET, SHEAR STRESS, AND ARTERIAL THROMBOSIS
    Role: Principal Investigator

    R01HL074729     (BRAY, PAUL F.)Sep 27, 2003 - Aug 31, 2009
    NIH
    Postmenopause CHD risk: Platelet genes &hormone therapy
    Role: Principal Investigator

    T32HL072754     (THIAGARAJAN, PERUMAL)Apr 1, 2004 - Mar 31, 2010
    NIH
    Basic and Clinical Research Training in Thrombosis
    Role: Co-Principal Investigator

    R01HL088458     (BRAY, PAUL F.)Sep 15, 2007 - Mar 31, 2013
    NIH
    Identifying genes regulating platelet reactivity
    Role: Principal Investigator

    R01HL102482     (BRAY, PAUL F.)Apr 26, 2010 - May 31, 2020
    NIH
    Variation in platelet function: human PAR4 functional genomics
    Role: Principal Investigator

    R01MD007880     (BRAY, PAUL F.)Jul 9, 2013 - Feb 28, 2019
    NIH
    Genetic regulation of racial differences in platelet reactivity
    Role: Principal Investigator

    R01HL116713     (BRAY, PAUL F.)Jan 1, 2014 - Nov 30, 2019
    NIH
    MicroRNA function in human megakarocytes
    Role: Principal Investigator

    R01HL141424     (BRAY, PAUL F.)Mar 15, 2018 - Apr 30, 2022
    NIH
    In vivo studies of megakaryocyte microRNAs regulating platelet number and integrin activation
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Montenont E, Bhatlekar S, Jacob S, Kosaka Y, Manne BK, Lee O, Parra-Izquierdo I, Tugolukova E, Tolley ND, Rondina MT, Bray PF, Rowley JW. CRISPR-edited megakaryocytes for rapid screening of platelet gene functions. Blood Adv. 2021 May 11; 5(9):2362-2374. PMID: 33944898.
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    2. Abou-Ismail MY, Rodgers GM, Bray PF, Lim MY. Acquired von Willebrand syndrome in monoclonal gammopathy - A scoping review on hemostatic management. Res Pract Thromb Haemost. 2021 Feb; 5(2):356-365. PMID: 33733035.
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    3. Loher P, Karathanasis N, Londin E, Bray P, Pliatsika V, Telonis AG, Rigoutsos I. IsoMiRmap-fast, deterministic, and exhaustive mining of isomiRs from short RNA-seq datasets. Bioinformatics. 2021 Jan 20. PMID: 33471076.
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    4. Bhatlekar S, Manne BK, Basak I, Edelstein LC, Tugolukova E, Stoller ML, Cody MJ, Morley SC, Nagalla S, Weyrich AS, Rowley JW, O'Connell RM, Rondina MT, Campbell RA, Bray PF. miR-125a-5p Regulates Megakaryocyte Proplatelet Formation Via the Actin Bundling Protein L-Plastin. Blood. 2020 Jul 07. PMID: 32844999.
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    5. Botero JP, Lee K, Branchford BR, Bray PF, Freson K, Lambert MP, Luo M, Mohan S, Ross JE, Bergmeier W, Di Paola J. Glanzmann thrombasthenia: genetic basis and clinical correlates. Haematologica. 2020 Apr; 105(4):888-894. PMID: 32139434.
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    6. Rondina M, Voora D, Simon L, Schwertz H, Harper J, Lee O, Bhatlekar S, Li Q, Eustes AS, Montenont E, Campbell RA, Tolley N, Kosaka Y, Weyrich A, Bray PF, Rowley JW. Longitudinal RNA-seq Analysis of the Repeatability of Gene Expression and Splicing in Human Platelets Identifies A Platelet SELP Splice QTL. Circ Res. 2019 Dec 19. PMID: 31852401.
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    7. Megy K, Downes K, Simeoni I, Bury L, Morales J, Mapeta R, Bellissimo DB, Bray PF, Goodeve AC, Gresele P, Lambert M, Reitsma P, Ouwehand WH, Freson K. Curated disease-causing genes for bleeding, thrombotic, and platelet disorders: Communication from the SSC of the ISTH. J Thromb Haemost. 2019 Aug; 17(8):1253-1260. PMID: 31179617.
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    8. Basak I, Bhatlekar S, Manne BK, Stoller M, Hugo S, Kong X, Ma L, Rondina MT, Weyrich AS, Edelstein LC, Bray PF. miR-15a-5p regulates expression of multiple proteins in the megakaryocyte GPVI signaling pathway. J Thromb Haemost. 2019 Mar; 17(3):511-524. PMID: 30632265.
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    9. Bhatlekar S, Basak I, Edelstein LC, Campbell RA, Lindsey CR, Italiano JE, Weyrich AS, Rowley JW, Rondina MT, Sola-Visner M, Bray PF. Anti-apoptotic BCL2L2 increases megakaryocyte proplatelet formation in cultures of human cord blood. Haematologica. 2019 Feb 07. PMID: 30733267.
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    10. Campbell RA, Schwertz H, Hottz ED, Rowley JW, Manne BK, Washington AV, Hunter-Mellado R, Tolley ND, Christensen M, Eustes AS, Montenont E, Bhatlekar S, Ventrone CH, Kirkpatrick BD, Pierce KK, Whitehead SS, Diehl SA, Bray PF, Zimmerman GA, Kosaka Y, Bozza PT, Bozza FA, Weyrich AS, Rondina MT. Human megakaryocytes possess intrinsic anti-viral immunity through regulated induction of IFITM3. Blood. 2019 Feb 05. PMID: 30723081.
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    11. Di Paola J, Bray PF. One over PAR or one under PAR: vive la différence. Blood. 2018 Nov 08; 132(19):2007-2008. PMID: 30409895.
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    12. Tricoci P, Neely M, Whitley MJ, Edelstein LC, Simon LM, Shaw C, Fortina P, Moliterno DJ, Armstrong PW, Aylward P, White H, Van de Werf F, Jennings LK, Wallentin L, Held C, Harrington RA, Mahaffey KW, Bray PF. Effects of genetic variation in protease activated receptor 4 after an acute coronary syndrome: Analysis from the TRACER trial. Blood Cells Mol Dis. 2018 Sep; 72:37-43. PMID: 30055940.
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    13. French SL, Thalmann C, Bray PF, Macdonald LE, Murphy AJ, Sleeman MW, Hamilton JR. A function-blocking PAR4 antibody is markedly antithrombotic in the face of a hyperreactive PAR4 variant. Blood Adv. 2018 Jun 12; 2(11):1283-1293. PMID: 29884748.
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    14. Tourdot BE, Stoveken H, Trumbo D, Yeung J, Kanthi Y, Edelstein LC, Bray PF, Tall GG, Holinstat M. Genetic Variant in Human PAR (Protease-Activated Receptor) 4 Enhances Thrombus Formation Resulting in Resistance to Antiplatelet Therapeutics. Arterioscler Thromb Vasc Biol. 2018 Jul; 38(7):1632-1643. PMID: 29748334.
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    15. Zou S, Teixeira AM, Kostadima M, Astle WJ, Radhakrishnan A, Simon LM, Truman L, Fang JS, Hwa J, Zhang PX, van der Harst P, Bray PF, Ouwehand WH, Frontini M, Krause DS. SNP in human ARHGEF3 promoter is associated with DNase hypersensitivity, transcript level and platelet function, and Arhgef3 KO mice have increased mean platelet volume. PLoS One. 2017; 12(5):e0178095. PMID: 28542600.
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    16. Kong X, Simon LM, Holinstat M, Shaw CA, Bray PF, Edelstein LC. Identification of a functional genetic variant driving racially dimorphic platelet gene expression of the thrombin receptor regulator, PCTP. Thromb Haemost. 2017 May 03; 117(5):962-970. PMID: 28251237.
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    17. Zhou Y, Abraham S, Renna S, Edelstein LC, Dangelmaier CA, Tsygankov AY, Kunapuli SP, Bray PF, McKenzie SE. TULA-2 (T-Cell Ubiquitin Ligand-2) Inhibits the Platelet Fc Receptor for IgG IIA (Fc?RIIA) Signaling Pathway and Heparin-Induced Thrombocytopenia in Mice. Arterioscler Thromb Vasc Biol. 2016 Dec; 36(12):2315-2323. PMID: 27765766.
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    18. Simon LM, Chen ES, Edelstein LC, Kong X, Bhatlekar S, Rigoutsos I, Bray PF, Shaw CA. Integrative Multi-omic Analysis of Human Platelet eQTLs Reveals Alternative Start Site in Mitofusin 2. Am J Hum Genet. 2016 May 5; 98(5):883-97. PMID: 27132591.
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    19. Simeoni I, Stephens JC, Hu F, Deevi SV, Megy K, Bariana TK, Lentaigne C, Schulman S, Sivapalaratnam S, Vries MJ, Westbury SK, Greene D, Papadia S, Alessi MC, Attwood AP, Ballmaier M, Baynam G, Bermejo E, Bertoli M, Bray PF, Bury L, Cattaneo M, Collins P, Daugherty LC, Favier R, French DL, Furie B, Gattens M, Germeshausen M, Ghevaert C, Goodeve AC, Guerrero JA, Hampshire DJ, Hart DP, Heemskerk JW, Henskens YM, Hill M, Hogg N, Jolley JD, Kahr WH, Kelly AM, Kerr R, Kostadima M, Kunishima S, Lambert MP, Liesner R, López JA, Mapeta RP, Mathias M, Millar CM, Nathwani A, Neerman-Arbez M, Nurden AT, Nurden P, Othman M, Peerlinck K, Perry DJ, Poudel P, Reitsma P, Rondina MT, Smethurst PA, Stevenson W, Szkotak A, Tuna S, van Geet C, Whitehorn D, Wilcox DA, Zhang B, Revel-Vilk S, Gresele P, Bellissimo DB, Penkett CJ, Laffan MA, Mumford AD, Rendon A, Gomez K, Freson K, Ouwehand WH, Turro E. A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders. Blood. 2016 Jun 9; 127(23):2791-803. PMID: 27084890.
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    20. Nagalla S, Bray PF. Personalized medicine in thrombosis: back to the future. Blood. 2016 Jun 2; 127(22):2665-71. PMID: 26847245.
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    21. Zhou Y, Abraham S, Andre P, Edelstein LC, Shaw CA, Dangelmaier CA, Tsygankov AY, Kunapuli SP, Bray PF, McKenzie SE. Anti-miR-148a regulates platelet Fc?RIIA signaling and decreases thrombosis in vivo in mice. Blood. 2015 Dec 24; 126(26):2871-81. PMID: 26516227.
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    22. Qayyum R, Becker LC, Becker DM, Faraday N, Yanek LR, Leal SM, Shaw C, Mathias R, Suktitipat B, Bray PF. Genome-wide association study of platelet aggregation in African Americans. BMC Genet. 2015; 16(1):58. PMID: 26024889.
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    23. Londin E, Loher P, Telonis AG, Quann K, Clark P, Jing Y, Hatzimichael E, Kirino Y, Honda S, Lally M, Ramratnam B, Comstock CE, Knudsen KE, Gomella L, Spaeth GL, Hark L, Katz LJ, Witkiewicz A, Rostami A, Jimenez SA, Hollingsworth MA, Yeh JJ, Shaw CA, McKenzie SE, Bray P, Nelson PT, Zupo S, Van Roosbroeck K, Keating MJ, Calin GA, Yeo C, Jimbo M, Cozzitorto J, Brody JR, Delgrosso K, Mattick JS, Fortina P, Rigoutsos I. Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs. Proc Natl Acad Sci U S A. 2015 Mar 10; 112(10):E1106-15. PMID: 25713380.
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    24. Edelstein LC, Simon LM, Lindsay CR, Kong X, Teruel-Montoya R, Tourdot BE, Chen ES, Ma L, Coughlin S, Nieman M, Holinstat M, Shaw CA, Bray PF. Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race. Blood. 2014 Nov 27; 124(23):3450-8. PMID: 25293779.
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    25. Tourdot BE, Conaway S, Niisuke K, Edelstein LC, Bray PF, Holinstat M. Mechanism of race-dependent platelet activation through the protease-activated receptor-4 and gq signaling axis. Arterioscler Thromb Vasc Biol. 2014 Dec; 34(12):2644-50. PMID: 25278289.
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    26. Teruel-Montoya R, Kong X, Abraham S, Ma L, Kunapuli SP, Holinstat M, Shaw CA, McKenzie SE, Edelstein LC, Bray PF. MicroRNA Expression Differences in Human Hematopoietic Cell Lineages Enable Regulated Transgene Expression. PLoS One. 2014; 9(7):e102259. PMID: 25029370.
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    27. Londin ER, Hatzimichael E, Loher P, Edelstein L, Shaw C, Delgrosso K, Fortina P, Bray PF, McKenzie SE, Rigoutsos I. The human platelet: strong transcriptome correlations among individuals associate weakly with the platelet proteome. Biol Direct. 2014; 9(1):3. PMID: 24524654.
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    28. Simon LM, Edelstein LC, Nagalla S, Woodley AB, Chen ES, Kong X, Ma L, Fortina P, Kunapuli S, Holinstat M, McKenzie SE, Dong JF, Shaw CA, Bray PF. Human platelet microRNA-mRNA networks associated with age and gender revealed by integrated plateletomics. Blood. 2014 Apr 17; 123(16):e37-45. PMID: 24523238.
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    29. Rincon F, Friedman DP, Bell R, Mayer SA, Bray PF. Targeted temperature management after intracerebral hemorrhage (TTM-ICH): methodology of a prospective randomized clinical trial. Int J Stroke. 2014 Jul; 9(5):646-51. PMID: 24450819.
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    30. Bray PF. Dengue platelets meet Sir Arthur Conan Doyle. Blood. 2013 Nov 14; 122(20):3400-1. PMID: 24235131.
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    31. Edelstein LC, Simon LM, Montoya RT, Holinstat M, Chen ES, Bergeron A, Kong X, Nagalla S, Mohandas N, Cohen DE, Dong JF, Shaw C, Bray PF. Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c. Nat Med. 2013 Dec; 19(12):1609-16. PMID: 24216752.
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    32. Garcia AE, Rico MC, Liverani E, Dela Cadena RA, Bray PF, Kunapuli SP. Erosive arthritis and hepatic granuloma formation induced by peptidoglycan polysaccharide in rats is aggravated by prasugrel treatment. PLoS One. 2013; 8(7):e69093. PMID: 23861957.
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    33. Bray PF, McKenzie SE, Edelstein LC, Nagalla S, Delgrosso K, Ertel A, Kupper J, Jing Y, Londin E, Loher P, Chen HW, Fortina P, Rigoutsos I. The complex transcriptional landscape of the anucleate human platelet. BMC Genomics. 2013; 14:1. PMID: 23323973.
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    34. Drelich DA, Bray PF, Herman JH. Immunoglobulin therapy and thrombosis: coincidence or causation? Transfusion. 2012 Oct; 52(10):2075-7. PMID: 23110730.
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    35. Stolla M, Pelisek J, von Brühl ML, Schäfer A, Barocke V, Heider P, Lorenz M, Tirniceriu A, Steinhart A, Bauersachs J, Bray PF, Massberg S, Schulz C. Fractalkine is expressed in early and advanced atherosclerotic lesions and supports monocyte recruitment via CX3CR1. PLoS One. 2012; 7(8):e43572. PMID: 22916279.
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    36. Edelstein LC, Luna EJ, Gibson IB, Bray M, Jin Y, Kondkar A, Nagalla S, Hadjout-Rabi N, Smith TC, Covarrubias D, Jones SN, Ahmad F, Stolla M, Kong X, Fang Z, Bergmeier W, Shaw C, Leal SM, Bray PF. Human genome-wide association and mouse knockout approaches identify platelet supervillin as an inhibitor of thrombus formation under shear stress. Circulation. 2012 Jun 5; 125(22):2762-71. PMID: 22550155.
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    37. Wang TY, Angiolillo DJ, Cushman M, Sabatine MS, Bray PF, Smyth SS, Dauerman HL, French PA, Becker RC. Platelet biology and response to antiplatelet therapy in women: implications for the development and use of antiplatelet pharmacotherapies for cardiovascular disease. J Am Coll Cardiol. 2012 Mar 6; 59(10):891-900. PMID: 22381424.
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    38. Edelstein LC, Bray PF. Small RNAs as Potential Platelet Therapeutics. Handb Exp Pharmacol. 2012; (210):435-45. PMID: 22918741.
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    39. Faraday N, Yanek LR, Yang XP, Mathias R, Herrera-Galeano JE, Suktitipat B, Qayyum R, Johnson AD, Chen MH, Tofler GH, Ruczinski I, Friedman AD, Gylfason A, Thorsteinsdottir U, Bray PF, O'Donnell CJ, Becker DM, Becker LC. Identification of a specific intronic PEAR1 gene variant associated with greater platelet aggregability and protein expression. Blood. 2011 Sep 22; 118(12):3367-75. PMID: 21791418.
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    40. Hong W, Kondkar AA, Nagalla S, Bergmeier W, Jin Y, Herman JH, Bray PF. Transfection of human platelets with short interfering RNA. Clin Transl Sci. 2011 Jun; 4(3):180-2. PMID: 21707948.
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    41. Nagalla S, Shaw C, Kong X, Kondkar AA, Edelstein LC, Ma L, Chen J, McKnight GS, López JA, Yang L, Jin Y, Bray MS, Leal SM, Dong JF, Bray PF. Platelet microRNA-mRNA coexpression profiles correlate with platelet reactivity. Blood. 2011 May 12; 117(19):5189-97. PMID: 21415270.
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    42. Edelstein LC, Bray PF. MicroRNAs in platelet production and activation. Blood. 2011 May 19; 117(20):5289-96. PMID: 21364189.
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    43. Bray PF, Leal SM. The 9p21.3 locus: platelets enter the fray. Circ Cardiovasc Genet. 2010 Oct; 3(5):393-5. PMID: 20959589.
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    44. Feldman AM, Force TL, Whellan DJ, Bray PF, Cheung JY, Koch WJ. Advancing the research mission in an academic department: the creation of a center for translational medicine. Clin Transl Sci. 2010 Aug; 3(4):178-81. PMID: 20718819.
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    45. Nagalla S, Bray PF. Platelet RNA chips dip into thrombocytosis. Blood. 2010 Jan 7; 115(1):2-3. PMID: 20056796.
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    46. Bray PF. Platelet genomics beats the catch-22. Blood. 2009 Aug 13; 114(7):1286-7. PMID: 19679698.
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    47. Nambi V, Kimball KT, Bray PF, Bergeron AL, Johnson SL, Morrisett JD, Chen C, Lin PH, Lumsden AB, Ballantyne CM, Dong JF. Differences in responses of platelets to fluid shear stress in patients with peripheral artery disease (PAD) and coronary artery disease (CAD). Platelets. 2009 May; 20(3):199-205. PMID: 19437338.
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    48. Ball C, Vijayan KV, Nguyen T, Anthony K, Bray PF, Essex DW, Dong JF. Glutathione regulates integrin alpha(IIb)beta(3)-mediated cell adhesion under flow conditions. Thromb Haemost. 2008 Nov; 100(5):857-63. PMID: 18989530.
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    49. Bergmeier W, Oh-Hora M, McCarl CA, Roden RC, Bray PF, Feske S. R93W mutation in Orai1 causes impaired calcium influx in platelets. Blood. 2009 Jan 15; 113(3):675-8. PMID: 18952890.
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    50. Kleiman NS, Freedman JE, Tracy PB, Furie BC, Bray PF, Rao SV, Phillips DR, Storey RF, Rusconi CP, French PA, Steinhubl SR, Becker RC. Platelets: developmental biology, physiology, and translatable platforms for preclinical investigation and drug development. Platelets. 2008 Jun; 19(4):239-51. PMID: 18569859.
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    51. Geng H, Zhang H, Zhang W, Nieswandt B, Bray PF, Leng X. Transdermal 17-beta estradiol replacement therapy reduces megakaryocyte GPVI expression. Thromb Res. 2008; 123(1):93-9. PMID: 18448154.
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    52. Bray PF, Larson JC, Lacroix AZ, Manson J, Limacher MC, Rossouw JE, Lasser NL, Lawson WE, Stefanick ML, Langer RD, Margolis KL. Usefulness of baseline lipids and C-reactive protein in women receiving menopausal hormone therapy as predictors of treatment-related coronary events. Am J Cardiol. 2008 Jun 1; 101(11):1599-1605. PMID: 18489937.
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    53. Payne KE, Bray PF, Grant PJ, Carter AM. Beta3 integrin haplotype influences gene regulation and plasma von Willebrand factor activity. Atherosclerosis. 2008 Jun; 198(2):280-6. PMID: 18045606.
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    54. Bray PF. Platelet hyperreactivity: predictive and intrinsic properties. Hematol Oncol Clin North Am. 2007 Aug; 21(4):633-45, v-vi. PMID: 17666282.
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    55. Faraday N, Yanek LR, Mathias R, Herrera-Galeano JE, Vaidya D, Moy TF, Fallin MD, Wilson AF, Bray PF, Becker LC, Becker DM. Heritability of platelet responsiveness to aspirin in activation pathways directly and indirectly related to cyclooxygenase-1. Circulation. 2007 May 15; 115(19):2490-6. PMID: 17470694.
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    56. Bray PF, Howard TD, Vittinghoff E, Sane DC, Herrington DM. Effect of genetic variations in platelet glycoproteins Ibalpha and VI on the risk for coronary heart disease events in postmenopausal women taking hormone therapy. Blood. 2007 Mar 1; 109(5):1862-9. PMID: 17105818.
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    57. Faraday N, Becker DM, Yanek LR, Herrera-Galeano JE, Segal JB, Moy TF, Bray PF, Becker LC. Relation between atherosclerosis risk factors and aspirin resistance in a primary prevention population. Am J Cardiol. 2006 Sep 15; 98(6):774-9. PMID: 16950183.
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    58. Hendrix SL, Wassertheil-Smoller S, Johnson KC, Howard BV, Kooperberg C, Rossouw JE, Trevisan M, Aragaki A, Baird AE, Bray PF, Buring JE, Criqui MH, Herrington D, Lynch JK, Rapp SR, Torner J. Effects of conjugated equine estrogen on stroke in the Women's Health Initiative. Circulation. 2006 May 23; 113(20):2425-34. PMID: 16702472.
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    59. Vijayan KV, Bray PF. Molecular mechanisms of prothrombotic risk due to genetic variations in platelet genes: Enhanced outside-in signaling through the Pro33 variant of integrin beta3. Exp Biol Med (Maywood). 2006 May; 231(5):505-13. PMID: 16636298.
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    60. Curb JD, Prentice RL, Bray PF, Langer RD, Van Horn L, Barnabei VM, Bloch MJ, Cyr MG, Gass M, Lepine L, Rodabough RJ, Sidney S, Uwaifo GI, Rosendaal FR. Venous thrombosis and conjugated equine estrogen in women without a uterus. Arch Intern Med. 2006 Apr 10; 166(7):772-80. PMID: 16606815.
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    61. Becker DM, Segal J, Vaidya D, Yanek LR, Herrera-Galeano JE, Bray PF, Moy TF, Becker LC, Faraday N. Sex differences in platelet reactivity and response to low-dose aspirin therapy. JAMA. 2006 Mar 22; 295(12):1420-7. PMID: 16551714.
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    62. Lev EI, Patel RT, Guthikonda S, Lopez D, Bray PF, Kleiman NS. Genetic polymorphisms of the platelet receptors P2Y(12), P2Y(1) and GP IIIa and response to aspirin and clopidogrel. Thromb Res. 2007; 119(3):355-60. PMID: 16581111.
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    63. Cooke GE, Liu-Stratton Y, Ferketich AK, Moeschberger ML, Frid DJ, Magorien RD, Bray PF, Binkley PF, Goldschmidt-Clermont PJ. Effect of platelet antigen polymorphism on platelet inhibition by aspirin, clopidogrel, or their combination. J Am Coll Cardiol. 2006 Feb 7; 47(3):541-6. PMID: 16458133.
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    64. Bray PF. Platelet reactivity and genetics down on the pharm. Trans Am Clin Climatol Assoc. 2006; 117:103-11; discussion 111-2. PMID: 18528467.
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    65. Lev EI, Patel RT, Maresh KJ, Guthikonda S, Granada J, DeLao T, Bray PF, Kleiman NS. Aspirin and clopidogrel drug response in patients undergoing percutaneous coronary intervention: the role of dual drug resistance. J Am Coll Cardiol. 2006 Jan 3; 47(1):27-33. PMID: 16386660.
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    66. Leng XH, Zhang W, Nieswandt B, Bray PF. Effects of estrogen replacement therapies on mouse platelet function and glycoprotein VI levels. Circ Res. 2005 Sep 2; 97(5):415-7. PMID: 16100041.
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    67. Yee DL, Sun CW, Bergeron AL, Dong JF, Bray PF. Aggregometry detects platelet hyperreactivity in healthy individuals. Blood. 2005 Oct 15; 106(8):2723-9. PMID: 15972447.
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    68. Vijayan KV, Liu Y, Sun W, Ito M, Bray PF. The Pro33 isoform of integrin beta3 enhances outside-in signaling in human platelets by regulating the activation of serine/threonine phosphatases. J Biol Chem. 2005 Jun 10; 280(23):21756-62. PMID: 15826939.
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    69. Margolis KL, Manson JE, Greenland P, Rodabough RJ, Bray PF, Safford M, Grimm RH, Howard BV, Assaf AR, Prentice R. Leukocyte count as a predictor of cardiovascular events and mortality in postmenopausal women: the Women's Health Initiative Observational Study. Arch Intern Med. 2005 Mar 14; 165(5):500-8. PMID: 15767524.
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    70. Faraday N, Martinez EA, Scharpf RB, Kasch-Semenza L, Dorman T, Pronovost PJ, Perler B, Gerstenblith G, Bray PF, Fleisher LA. Platelet gene polymorphisms and cardiac risk assessment in vascular surgical patients. Anesthesiology. 2004 Dec; 101(6):1291-7. PMID: 15564935.
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    71. Yee DL, Bray PF. Clinical and functional consequences of platelet membrane glycoprotein polymorphisms. Semin Thromb Hemost. 2004 Oct; 30(5):591-600. PMID: 15497101.
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    72. Vijayan KV, Liu Y, Li TT, Bray PF. Protein phosphatase 1 associates with the integrin alphaIIb subunit and regulates signaling. J Biol Chem. 2004 Aug 6; 279(32):33039-42. PMID: 15205468.
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    73. Li TT, Larrucea S, Souza S, Leal SM, López JA, Rubin EM, Nieswandt B, Bray PF. Genetic variation responsible for mouse strain differences in integrin alpha 2 expression is associated with altered platelet responses to collagen. Blood. 2004 May 1; 103(9):3396-402. PMID: 14739220.
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    74. Leng XH, Hong SY, Larrucea S, Zhang W, Li TT, López JA, Bray PF. Platelets of female mice are intrinsically more sensitive to agonists than are platelets of males. Arterioscler Thromb Vasc Biol. 2004 Feb; 24(2):376-81. PMID: 14656736.
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    75. Julapalli VR, Bray PF, Duchini A. Elevated factor VIII and portal vein thrombosis. Dig Dis Sci. 2003 Dec; 48(12):2369-71. PMID: 14714627.
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    76. Zhang JN, Bergeron AL, Yu Q, Sun C, McBride L, Bray PF, Dong JF. Duration of exposure to high fluid shear stress is critical in shear-induced platelet activation-aggregation. Thromb Haemost. 2003 Oct; 90(4):672-8. PMID: 14515188.
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    77. Vijayan KV, Huang TC, Liu Y, Bernardo A, Dong JF, Goldschmidt-Clermont PJ, Alevriadou BR, Bray PF. Shear stress augments the enhanced adhesive phenotype of cells expressing the Pro33 isoform of integrin beta3. FEBS Lett. 2003 Apr 10; 540(1-3):41-6. PMID: 12681480.
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    78. Kurrelmeyer K, Becker L, Becker D, Yanek L, Goldschmidt-Clermont P, Bray PF. Platelet hyperreactivity in women from families with premature atherosclerosis. J Am Med Womens Assoc. 2003; 58(4):272-7. PMID: 14640259.
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    79. Sajid M, Vijayan KV, Souza S, Bray PF. PlA polymorphism of integrin beta 3 differentially modulates cellular migration on extracellular matrix proteins. Arterioscler Thromb Vasc Biol. 2002 Dec 1; 22(12):1984-9. PMID: 12482823.
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    80. Vijayan KV, Liu Y, Dong JF, Bray PF. Enhanced activation of mitogen-activated protein kinase and myosin light chain kinase by the Pro33 polymorphism of integrin beta 3. J Biol Chem. 2003 Feb 7; 278(6):3860-7. PMID: 12460991.
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    81. Wheeler GL, Braden GA, Bray PF, Marciniak SJ, Mascelli MA, Sane DC. Reduced inhibition by abciximab in platelets with the PlA2 polymorphism. Am Heart J. 2002 Jan; 143(1):76-82. PMID: 11773915.
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