Philippe Frank

TitleAsst Professor
InstitutionThomas Jefferson University
DepartmentStem Cell Biology And Regen Md
Address233 S. 10th Street
Philadelphia PA 19107
Phone215-503-9292
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    R01CA098779     (FRANK, PHILIPPE G.)Jan 23, 2003 - Dec 31, 2013
    NIH
    CAV-1, Stat5a Signaling, and Estrogen-Dependent Breast Cancer
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Goupille C, Ouldamer L, Pinault M, Guimares C, Arbion F, Jourdan ML, Frank PG. Identification of a Positive Association between Mammary Adipose Cholesterol Content and Indicators of Breast Cancer Aggressiveness in a French Population. J Nutr. 2021 Apr 08. PMID: 33831951.
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    2. Goupille C, Frank PG, Arbion F, Jourdan ML, Guimaraes C, Pinault M, Body G, Chevalier S, Bougnoux P, Ouldamer L. Low Levels of Omega-3 Long-Chain Polyunsaturated Fatty Acids Are Associated with Bone Metastasis Formation in Premenopausal Women with Breast Cancer: A Retrospective Study. Nutrients. 2020 Dec 15; 12(12). PMID: 33333962.
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    3. Goupille C, Vibet S, Frank PG, Mahéo K. EPA and DHA Fatty Acids Induce a Remodeling of Tumor Vasculature and Potentiate Docetaxel Activity. Int J Mol Sci. 2020 Jul 14; 21(14). PMID: 32674321.
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    4. Pinault M, Guimaraes C, Ben Hassen C, Gutierrez-Pajares JL, Chevalier S, Goupille C, Bernard-Savary P, Frank PG. Development of a Novel High-Performance Thin Layer Chromatography-Based Method for the Simultaneous Quantification of Clinically Relevant Lipids from Cells and Tissue Extracts. Lipids. 2020 May 18. PMID: 32424826.
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    5. Ben Hassen C, Gutierrez-Pajares JL, Guimaraes C, Guibon R, Pinault M, Fromont G, Frank PG. Apolipoprotein-mediated regulation of lipid metabolism induces distinctive effects in different types of breast cancer cells. Breast Cancer Res. 2020 Apr 22; 22(1):38. PMID: 32321558.
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    6. Gutierrez-Pajares JL, Ben Hassen C, Oger C, Galano JM, Durand T, Frank PG. Oxidized Products of a-Linolenic Acid Negatively Regulate Cellular Survival and Motility of Breast Cancer Cells. Biomolecules. 2019 Dec 28; 10(1). PMID: 31905626.
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    7. Bon E, Driffort V, Gradek F, Martinez-Caceres C, Anchelin M, Pelegrin P, Cayuela ML, Marionneau-Lambot S, Oullier T, Guibon R, Fromont G, Gutierrez-Pajares JL, Domingo I, Piver E, Moreau A, Burlaud-Gaillard J, Frank PG, Chevalier S, Besson P, Roger S. SCN4B acts as a metastasis-suppressor gene preventing hyperactivation of cell migration in breast cancer. Nat Commun. 2016 Dec 05; 7:13648. PMID: 27917859.
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    8. Gutierrez-Pajares JL, Ben Hassen C, Chevalier S, Frank PG. SR-BI: Linking Cholesterol and Lipoprotein Metabolism with Breast and Prostate Cancer. Front Pharmacol. 2016; 7:338. PMID: 27774064.
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    9. Gutierrez-Pajares JL, Iturrieta J, Dulam V, Wang Y, Pavlides S, Malacari G, Lisanti MP, Frank PG. Caveolin-3 Promotes a Vascular Smooth Muscle Contractile Phenotype. Front Cardiovasc Med. 2015; 2:27. PMID: 26664898.
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    10. Pavlides S, Gutierrez-Pajares JL, Katiyar S, Jasmin JF, Mercier I, Walters R, Pavlides C, Pestell RG, Lisanti MP, Frank PG. Caveolin-1 regulates the anti-atherogenic properties of macrophages. Cell Tissue Res. 2014 Dec; 358(3):821-31. PMID: 25322709.
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    11. Pavlides S, Gutierrez-Pajares JL, Iturrieta J, Lisanti MP, Frank PG. Endothelial caveolin-1 plays a major role in the development of atherosclerosis. Cell Tissue Res. 2014 Apr; 356(1):147-57. PMID: 24390341.
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    12. Danilo C, Gutierrez-Pajares JL, Mainieri MA, Mercier I, Lisanti MP, Frank PG. Scavenger receptor class B type I regulates cellular cholesterol metabolism and cell signaling associated with breast cancer development. Breast Cancer Res. 2013 Sep 24; 15(5):R87. PMID: 24060386.
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    13. Danilo C, Frank PG. Cholesterol and breast cancer development. Curr Opin Pharmacol. 2012 Dec; 12(6):677-82. PMID: 22867847.
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    14. Pavlides S, Gutierrez-Pajares JL, Danilo C, Lisanti MP, Frank PG. Atherosclerosis, caveolae and caveolin-1. Adv Exp Med Biol. 2012; 729:127-44. PMID: 22411318.
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    15. de Almeida CJ, Witkiewicz AK, Jasmin JF, Tanowitz HB, Sotgia F, Frank PG, Lisanti MP. Caveolin-2-deficient mice show increased sensitivity to endotoxemia. Cell Cycle. 2011 Jul 1; 10(13):2151-61. PMID: 21670588.
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    16. Llaverias G, Danilo C, Mercier I, Daumer K, Capozza F, Williams TM, Sotgia F, Lisanti MP, Frank PG. Role of cholesterol in the development and progression of breast cancer. Am J Pathol. 2011 Jan; 178(1):402-12. PMID: 21224077.
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    17. Llaverias G, Danilo C, Wang Y, Witkiewicz AK, Daumer K, Lisanti MP, Frank PG. A Western-type diet accelerates tumor progression in an autochthonous mouse model of prostate cancer. Am J Pathol. 2010 Dec; 177(6):3180-91. PMID: 21088217.
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    18. Frank PG. Endothelial caveolae and caveolin-1 as key regulators of atherosclerosis. Am J Pathol. 2010 Aug; 177(2):544-6. PMID: 20581059.
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    19. Raval M, Frank PG, Laury-Kleintop L, Yan G, Lanza-Jacoby S. Celecoxib combined with atorvastatin prevents progression of atherosclerosis. J Surg Res. 2010 Oct; 163(2):e113-22. PMID: 20538289.
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    20. Frank PG, Pavlides S, Lisanti MP. Caveolae and transcytosis in endothelial cells: role in atherosclerosis. Cell Tissue Res. 2009 Jan; 335(1):41-7. PMID: 18688651.
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    21. Frank PG, Lisanti MP. ICAM-1: role in inflammation and in the regulation of vascular permeability. Am J Physiol Heart Circ Physiol. 2008 Sep; 295(3):H926-H927. PMID: 18689494.
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    22. Frank PG, Pavlides S, Cheung MW, Daumer K, Lisanti MP. Role of caveolin-1 in the regulation of lipoprotein metabolism. Am J Physiol Cell Physiol. 2008 Jul; 295(1):C242-8. PMID: 18508910.
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    23. Frank PG, Lisanti MP. Caveolin-1 and liver regeneration: role in proliferation and lipogenesis. Cell Cycle. 2007 Jan 15; 6(2):115-6. PMID: 17314510.
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    24. Frank PG, Hassan GS, Rodriguez-Feo JA, Lisanti MP. Caveolae and caveolin-1: novel potential targets for the treatment of cardiovascular disease. Curr Pharm Des. 2007; 13(17):1761-9. PMID: 17584106.
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    25. Frank PG, Lisanti MP. Zebrafish as a novel model system to study the function of caveolae and caveolin-1 in organismal biology. Am J Pathol. 2006 Dec; 169(6):1910-2. PMID: 17148656.
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    26. Frank PG, Lisanti MP. Role of caveolin-1 in the regulation of the vascular shear stress response. J Clin Invest. 2006 May; 116(5):1222-5. PMID: 16670766.
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    27. Frank PG, Cheung MW, Pavlides S, Llaverias G, Park DS, Lisanti MP. Caveolin-1 and regulation of cellular cholesterol homeostasis. Am J Physiol Heart Circ Physiol. 2006 Aug; 291(2):H677-86. PMID: 16603689.
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    28. Frank PG, Lisanti MP. Defining lipid raft structure and function with proximity imaging. Am J Physiol Heart Circ Physiol. 2006 Jun; 290(6):H2165-6. PMID: 16428346.
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    29. Frank PG, Lisanti MP. Caveolin-1 and caveolae in atherosclerosis: differential roles in fatty streak formation and neointimal hyperplasia. Curr Opin Lipidol. 2004 Oct; 15(5):523-9. PMID: 15361787.
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    30. Frank PG, Lee H, Park DS, Tandon NN, Scherer PE, Lisanti MP. Genetic ablation of caveolin-1 confers protection against atherosclerosis. Arterioscler Thromb Vasc Biol. 2004 Jan; 24(1):98-105. PMID: 14563650.
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    31. Frank PG, Woodman SE, Park DS, Lisanti MP. Caveolin, caveolae, and endothelial cell function. Arterioscler Thromb Vasc Biol. 2003 Jul 1; 23(7):1161-8. PMID: 12689915.
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    32. Frank PG, Marcel YL, Connelly MA, Lublin DM, Franklin V, Williams DL, Lisanti MP. Stabilization of caveolin-1 by cellular cholesterol and scavenger receptor class B type I. Biochemistry. 2002 Oct 1; 41(39):11931-40. PMID: 12269838.
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    33. Frank PG, Pedraza A, Cohen DE, Lisanti MP. Adenovirus-mediated expression of caveolin-1 in mouse liver increases plasma high-density lipoprotein levels. Biochemistry. 2001 Sep 11; 40(36):10892-900. PMID: 11535066.
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    34. Frank PG, Galbiati F, Volonte D, Razani B, Cohen DE, Marcel YL, Lisanti MP. Influence of caveolin-1 on cellular cholesterol efflux mediated by high-density lipoproteins. Am J Physiol Cell Physiol. 2001 May; 280(5):C1204-14. PMID: 11287334.
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    35. Frank PG, Marcel YL. Apolipoprotein A-I: structure-function relationships. J Lipid Res. 2000 Jun; 41(6):853-72. PMID: 10828078.
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    36. Burgess JW, Frank PG, Franklin V, Liang P, McManus DC, Desforges M, Rassart E, Marcel YL. Deletion of the C-terminal domain of apolipoprotein A-I impairs cell surface binding and lipid efflux in macrophage. Biochemistry. 1999 Nov 2; 38(44):14524-33. PMID: 10545174.
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    37. Frank PG, N'Guyen D, Franklin V, Neville T, Desforges M, Rassart E, Sparks DL, Marcel YL. Importance of central alpha-helices of human apolipoprotein A-I in the maturation of high-density lipoproteins. Biochemistry. 1998 Sep 29; 37(39):13902-9. PMID: 9753480.
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    38. Frank PG, Bergeron J, Emmanuel F, Lavigne JP, Sparks DL, Denèfle P, Rassart E, Marcel YL. Deletion of central alpha-helices in human apolipoprotein A-I: effect on phospholipid association. Biochemistry. 1997 Feb 18; 36(7):1798-806. PMID: 9048564.
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    39. Bergeron J, Frank PG, Scales D, Meng QH, Castro G, Marcel YL. Apolipoprotein A-I conformation in reconstituted discoidal lipoproteins varying in phospholipid and cholesterol content. J Biol Chem. 1995 Nov 17; 270(46):27429-38. PMID: 7499199.
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