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Paolo Fortina

TitleProfessor
InstitutionThomas Jefferson University
DepartmentSidney Kimmel Cancer Center
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    R21CA083220     (FORTINA, PAOLO M)Sep 26, 2000 - Apr 30, 2002
    NIH/NCI
    FOUR COLOR ARRAY BOUND SNP/MUTATION DETECTION IN CANCER
    Role: Principal Investigator

    R33CA083220     (FORTINA, PAOLO M)Sep 26, 2000 - Sep 2, 2002
    NIH/NCI
    FOUR COLOR ARRAY BOUND SNP/MUTATION DETECTION IN CANCER
    Role: Principal Investigator

    S10OD025128     (FORTINA, PAOLO M)Aug 27, 2020 - Aug 26, 2021
    NIH
    Ultrahigh Throughput Sequencing System
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Rasouli J, Casella G, Yoshimura S, Zhang W, Xiao D, Garifallou J, Gonzalez MV, Wiedeman A, Kus A, Mari ER, Fortina P, Hakonarson H, Long SA, Zhang GX, Ciric B, Rostami A. A distinct GM-CSF+ T helper cell subset requires T-bet to adopt a TH1 phenotype and promote neuroinflammation. Sci Immunol. 2020 10 23; 5(52). PMID: 33097590.
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    2. Kricka LJ, Polevikov S, Park JY, Fortina P, Bernardini S, Satchkov D, Kolesov V, Grishkov M. Artificial Intelligence-Powered Search Tools and Resources in the Fight Against COVID-19. EJIFCC. 2020 Jun; 31(2):106-116. PMID: 32549878.
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    3. Quaglia F, Krishn SR, Daaboul GG, Sarker S, Pippa R, Domingo-Domenech J, Kumar G, Fortina P, McCue P, Kelly WK, Beltran H, Liu Q, Languino LR. Small extracellular vesicles modulated by aVß3 integrin induce neuroendocrine differentiation in recipient cancer cells. J Extracell Vesicles. 2020 May 24; 9(1):1761072. PMID: 32922691.
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    4. Upton K, Modi A, Patel K, Kendsersky NM, Conkrite KL, Sussman RT, Way GP, Adams RN, Sacks GI, Fortina P, Diskin SJ, Maris JM, Rokita JL. Epigenomic profiling of neuroblastoma cell lines. Sci Data. 2020 04 14; 7(1):116. PMID: 32286315.
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    5. Chen J, Martindale JL, Abdelmohsen K, Kumar G, Fortina PM, Gorospe M, Rostami A, Yu S. RNA-Binding Protein HuR Promotes Th17 Cell Differentiation and Can Be Targeted to Reduce Autoimmune Neuroinflammation. J Immunol. 2020 Apr 15; 204(8):2076-2087. PMID: 32169842.
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    6. Kumar G, Ertel A, Feldman G, Kupper J, Fortina P. iSeqQC: a tool for expression-based quality control in RNA sequencing. BMC Bioinformatics. 2020 Feb 13; 21(1):56. PMID: 32054449.
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    7. De Dominici M, Porazzi P, Xiao Y, Chao A, Tang HY, Kumar G, Fortina P, Spinelli O, Rambaldi A, Peterson LF, Petruk S, Barletta C, Mazo A, Cingolani G, Salvino JM, Calabretta B. Selective inhibition of Ph-positive ALL cell growth through kinase-dependent and independent effects by CDK6-specific PROTACs. Blood. 2020 Feb 07. PMID: 32040545.
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    8. Gobbi G, Carubbi C, Tagliazucchi GM, Masselli E, Mirandola P, Pigazzani F, Crocamo A, Notarangelo MF, Suma S, Paraboschi E, Maglietta G, Nagalla S, Pozzi G, Galli D, Vaccarezza M, Fortina P, Addya S, Ertel A, Bray P, Duga S, Berzuini C, Vitale M, Ardissino D. Sighting acute myocardial infarction through platelet gene expression. Sci Rep. 2019 Dec 20; 9(1):19574. PMID: 31863085.
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    9. Meyer LK, Huang BJ, Delgado-Martin C, Roy RP, Hechmer A, Wandler AM, Vincent TL, Fortina P, Olshen AB, Wood BL, Horton TM, Shannon KM, Teachey DT, Hermiston ML. Glucocorticoids paradoxically facilitate steroid resistance in T-cell acute lymphoblastic leukemias and thymocytes. J Clin Invest. 2019 Nov 05. PMID: 31687977.
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    10. Simonneau C, Yang J, Kong X, Kilker R, Edelstein L, Fortina P, Londin E, Horowitz A. Validation of a Miniaturized Permeability Assay Compatible with CRISPR-Mediated Genome-Wide Screen. Sci Rep. 2019 Oct 02; 9(1):14238. PMID: 31578372.
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    11. Greaves RF, Bernardini S, Ferrari M, Fortina P, Gouget B, Gruson D, Lang T, Loh TP, Morris HA, Park JY, Roessler M, Yin P, Kricka LJ. Key questions about the future of laboratory medicine in the next decade of the 21st century: A report from the IFCC-Emerging Technologies Division. Clin Chim Acta. 2019 Aug; 495:570-589. PMID: 31145895.
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    12. Paolillo C, Londin E, Fortina P. Single-Cell Genomics. Clin Chem. 2019 Mar 14. PMID: 30872376.
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    13. Youssefian L, Vahidnezhad H, Yousefi M, Saeidian AH, Azizpour A, Touati A, Nikbakht N, Hesari KK, Adib-Sereshki MM, Zeinali S, Mansoori B, Jazayeri A, Karamzadeh R, Fortina P, Jouanguy E, Casanova JL, Uitto J. Inherited Interleukin 2-Inducible T-Cell (ITK) Kinase Deficiency in Siblings With Epidermodysplasia Verruciformis and Hodgkin Lymphoma. Clin Infect Dis. 2019 Feb 19. PMID: 30778533.
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    14. Youssefian L, Vahidnezhad H, Saeidian AH, Touati A, Sotoudeh S, Mahmoudi H, Mansouri P, Daneshpazhooh M, Aghazadeh N, Hesari KK, Basiri M, Londin E, Kumar G, Zeinali S, Fortina P, Uitto J. Autosomal recessive congenital ichthyosis: Genomic landscape and phenotypic spectrum in a cohort of 125 consanguineous families. Hum Mutat. 2019 Mar; 40(3):288-298. PMID: 30578701.
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    15. Youssefian L, Vahidnezhad H, Saeidian AH, Mahmoudi H, Karamzadeh R, Kariminejad A, Huang J, Li L, Jannace TF, Fortina P, Zeinali S, White TW, Uitto J. A novel autosomal recessive GJB2-associated disorder: Ichthyosis follicularis, bilateral severe sensorineural hearing loss, and punctate palmoplantar keratoderma. Hum Mutat. 2019 Feb; 40(2):217-229. PMID: 30431684.
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    16. Teh JLF, Cheng PF, Purwin TJ, Nikbakht N, Patel P, Chervoneva I, Ertel A, Fortina PM, Kleiber I, HooKim K, Davies MA, Kwong LN, Levesque MP, Dummer R, Aplin AE. Correction: In Vivo E2F Reporting Reveals Efficacious Schedules of MEK1/2-CDK4/6 Targeting and mTOR-S6 Resistance Mechanisms. Cancer Discov. 2018 Dec; 8(12):1654. PMID: 30510016.
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    17. Tricoci P, Neely M, Whitley MJ, Edelstein LC, Simon LM, Shaw C, Fortina P, Moliterno DJ, Armstrong PW, Aylward P, White H, Van de Werf F, Jennings LK, Wallentin L, Held C, Harrington RA, Mahaffey KW, Bray PF. Effects of genetic variation in protease activated receptor 4 after an acute coronary syndrome: Analysis from the TRACER trial. Blood Cells Mol Dis. 2018 Sep; 72:37-43. PMID: 30055940.
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    18. Lu H, Bowler N, Harshyne LA, Craig Hooper D, Krishn SR, Kurtoglu S, Fedele C, Liu Q, Tang HY, Kossenkov AV, Kelly WK, Wang K, Kean RB, Weinreb PH, Yu L, Dutta A, Fortina P, Ertel A, Stanczak M, Forsberg F, Gabrilovich DI, Speicher DW, Altieri DC, Languino LR. Exosomal avß6 integrin is required for monocyte M2 polarization in prostate cancer. Matrix Biol. 2018 Mar 09. PMID: 29530483.
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    19. Teh JLF, Cheng PF, Purwin TJ, Nikbakht N, Patel P, Chervoneva I, Ertel A, Fortina PM, Kleiber I, HooKim K, Davies MA, Kwong LN, Levesque MP, Dummer R, Aplin AE. In vivo E2F reporting reveals efficacious schedules of MEK1/2-CDK4/6 targeting and mTOR-S6 resistance mechanisms. Cancer Discov. 2018 Mar 01. PMID: 29496664.
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    20. Sponziello M, Benvenuti S, Gentile A, Pecce V, Rosignolo F, Virzì AR, Milan M, Comoglio PM, Londin E, Fortina P, Barnabei A, Appetecchia M, Marandino F, Russo D, Filetti S, Durante C, Verrienti A. Whole exome sequencing identifies a germline MET mutation in two siblings with hereditary wild-type RET medullary thyroid cancer. Hum Mutat. 2018 Mar; 39(3):371-377. PMID: 29219214.
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    21. De Dominici M, Porazzi P, Soliera AR, Mariani SA, Addya S, Fortina P, Peterson LF, Spinelli O, Rambaldi A, Martinelli G, Ferrari A, Iacobucci I, Calabretta B. Targeting CDK6 and BCL2 Exploits the "MYB Addiction" of Ph+ Acute Lymphoblastic Leukemia. Cancer Res. 2018 Feb 15; 78(4):1097-1109. PMID: 29233926.
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    22. Harenza JL, Diamond MA, Adams RN, Song MM, Davidson HL, Hart LS, Dent MH, Fortina P, Reynolds CP, Maris JM. Corrigendum: Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines. Sci Data. 2017 12 05; 4:170183. PMID: 29206221.
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    23. Vahidnezhad H, Youssefian L, Saeidian AH, Mahmoudi H, Touati A, Abiri M, Kajbafzadeh AM, Aristodemou S, Liu L, McGrath JA, Ertel A, Londin E, Kariminejad A, Zeinali S, Fortina P, Uitto J. Recessive mutation in tetraspanin CD151 causes Kindler syndrome-like epidermolysis bullosa with multi-systemic manifestations including nephropathy. Matrix Biol. 2018 Mar; 66:22-33. PMID: 29138120.
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    24. Youssefian L, Vahidnezhad H, Saeidian AH, Sotoudeh S, Mahmoudi H, Daneshpazhooh M, Aghazadeh N, Adams R, Ghanadan A, Zeinali S, Fortina P, Uitto J. Autosomal recessive congenital ichthyosis: CERS3 mutations identified by a next generation sequencing panel targeting ichthyosis genes. Eur J Hum Genet. 2017 11; 25(11):1282-1285. PMID: 28875980.
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    25. Vahidnezhad H, Youssefian L, Saeidian AH, Touati A, Sotoudeh S, Abiri M, Barzegar M, Aghazadeh N, Mahmoudi H, Norouz-Zadeh S, Hamid M, Zahabiyon M, Bagherian H, Zeinali S, Fortina P, Uitto J. Multigene Next-Generation Sequencing Panel Identifies Pathogenic Variants in Patients with Unknown Subtype of Epidermolysis Bullosa: Subclassification with Prognostic Implications. J Invest Dermatol. 2017 Dec; 137(12):2649-2652. PMID: 28830826.
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    26. Paolillo C, Mu Z, Rossi G, Schiewer MJ, Nguyen T, Austin L, Capoluongo E, Knudsen KE, Cristofanilli M, Fortina P. Detection of Activating Estrogen Receptor Gene (ESR1) Mutations in Single Circulating Tumor Cells. Clin Cancer Res. 2017 Jul 05. PMID: 28679775.
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    27. Kageyama K, Ohara M, Saito K, Ozaki S, Terai M, Mastrangelo MJ, Fortina P, Aplin AE, Sato T. Establishment of an orthotopic patient-derived xenograft mouse model using uveal melanoma hepatic metastasis. J Transl Med. 2017 Jun 23; 15(1):145. PMID: 28645290.
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    28. Harenza JL, Diamond MA, Adams RN, Song MM, Davidson HL, Hart LS, Dent MH, Fortina P, Reynolds CP, Maris JM. Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines. Sci Data. 2017 03 28; 4:170033. PMID: 28350380.
      View in: PubMed
    29. Vahidnezhad H, Youssefian L, Saeidian AH, Zeinali S, Mansouri P, Sotoudeh S, Barzegar M, Mohammadi-Asl J, Karamzadeh R, Abiri M, McCormick K, Fortina P, Uitto J. Gene Targeted Next Generation Sequencing Identifies PNPLA1 Mutations in Patients with a Phenotypic Spectrum of Autosomal Recessive Congenital Ichthyosis: The Impact of Consanguinity. J Invest Dermatol. 2016 Nov 21. PMID: 27884779.
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    30. Vahidnezhad H, Youssefian L, Zeinali S, Saeidian AH, Sotoudeh S, Mozafari N, Abiri M, Kajbafzadeh AM, Barzegar M, Ertel A, Fortina P, Uitto J. Dystrophic Epidermolysis Bullosa: COL7A1 Mutation Landscape in a Multi-Ethnic Cohort of 152 Extended Families with High Degree of Customary Consanguineous Marriages. J Invest Dermatol. 2017 Mar; 137(3):660-669. PMID: 27899325.
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    31. Mu Z, Benali-Furet N, Uzan G, Znaty A, Ye Z, Paolillo C, Wang C, Austin L, Rossi G, Fortina P, Yang H, Cristofanilli M. Detection and Characterization of Circulating Tumor Associated Cells in Metastatic Breast Cancer. Int J Mol Sci. 2016 Sep 30; 17(10). PMID: 27706044.
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    32. Vozikis A, Cooper DN, Mitropoulou C, Kambouris ME, Brand A, Dolzan V, Fortina P, Innocenti F, Lee MT, Leyens L, Macek M, Al-Mulla F, Prainsack B, Squassina A, Taruscio D, van Schaik RH, Vayena E, Williams MS, Patrinos GP. Test Pricing and Reimbursement in Genomic Medicine: Towards a General Strategy. Public Health Genomics. 2016; 19(6):352-363. PMID: 27676083.
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    33. Paolillo C, Londin E, Fortina P. Next generation sequencing in cancer: opportunities and challenges for precision cancer medicine. Scand J Clin Lab Invest Suppl. 2016; 245:S84-91. PMID: 27542004.
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    34. Kricka LJ, Fortina P, Park JY. Nanostructured luminescently labeled nucleic acids. Luminescence. 2017 Mar; 32(2):132-141. PMID: 27417153.
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    35. Gogoi P, Sepehri S, Zhou Y, Gorin MA, Paolillo C, Capoluongo E, Gleason K, Payne A, Boniface B, Cristofanilli M, Morgan TM, Fortina P, Pienta KJ, Handique K, Wang Y. Development of an Automated and Sensitive Microfluidic Device for Capturing and Characterizing Circulating Tumor Cells (CTCs) from Clinical Blood Samples. PLoS One. 2016; 11(1):e0147400. PMID: 26808060.
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    36. Liao Z, Gu L, Vergalli J, Mariani SA, De Dominici M, Lokareddy RK, Dagvadorj A, Purushottamachar P, McCue PA, Trabulsi E, Lallas CD, Gupta S, Ellsworth E, Blackmon S, Ertel A, Fortina P, Leiby B, Xia G, Rui H, Hoang DT, Gomella LG, Cingolani G, Njar V, Pattabiraman N, Calabretta B, Nevalainen MT. Structure-Based Screen Identifies a Potent Small Molecule Inhibitor of Stat5a/b with Therapeutic Potential for Prostate Cancer and Chronic Myeloid Leukemia. Mol Cancer Ther. 2015 Aug; 14(8):1777-93. PMID: 26026053.
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    37. Casimiro MC, Di Sante G, Crosariol M, Loro E, Dampier W, Ertel A, Yu Z, Saria EA, Papanikolaou A, Li Z, Wang C, Addya S, Lisanti MP, Fortina P, Cardiff RD, Tozeren A, Knudsen ES, Arnold A, Pestell RG. Kinase-independent role of cyclin D1 in chromosomal instability and mammary tumorigenesis. Oncotarget. 2015 Apr 20; 6(11):8525-38. PMID: 25940700.
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    38. Londin E, Loher P, Telonis AG, Quann K, Clark P, Jing Y, Hatzimichael E, Kirino Y, Honda S, Lally M, Ramratnam B, Comstock CE, Knudsen KE, Gomella L, Spaeth GL, Hark L, Katz LJ, Witkiewicz A, Rostami A, Jimenez SA, Hollingsworth MA, Yeh JJ, Shaw CA, McKenzie SE, Bray P, Nelson PT, Zupo S, Van Roosbroeck K, Keating MJ, Calin GA, Yeo C, Jimbo M, Cozzitorto J, Brody JR, Delgrosso K, Mattick JS, Fortina P, Rigoutsos I. Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs. Proc Natl Acad Sci U S A. 2015 Mar 10; 112(10):E1106-15. PMID: 25713380.
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    39. Knudsen ES, McClendon AK, Franco J, Ertel A, Fortina P, Witkiewicz AK. RB loss contributes to aggressive tumor phenotypes in MYC-driven triple negative breast cancer. Cell Cycle. 2015 Jan 2; 14(1):109-22. PMID: 25602521.
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    40. Park JY, Clark P, Londin E, Sponziello M, Kricka LJ, Fortina P. Clinical exome performance for reporting secondary genetic findings. Clin Chem. 2015 Jan; 61(1):213-20. PMID: 25414276.
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    41. Kricka LJ, Polsky TG, Park JY, Fortina P. The future of laboratory medicine - a 2014 perspective. Clin Chim Acta. 2015 Jan 1; 438:284-303. PMID: 25219903.
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    42. Cooper DN, Brand A, Dolzan V, Fortina P, Innocenti F, Michael Lee MT, Macek M, Al-Mulla F, Prainsack B, Squassina A, Vayena E, Vozikis A, Williams MS, Patrinos GP. Bridging genomics research between developed and developing countries: the Genomic Medicine Alliance. Per Med. 2014 Sep; 11(7):615-623. PMID: 29764053.
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    43. Thangavel C, Boopathi E, Ciment S, Liu Y, O' Neill R, Sharma A, McMahon SB, Mellert H, Addya S, Ertel A, Birbe R, Fortina P, Dicker AP, Knudsen KE, Den RB. The retinoblastoma tumor suppressor modulates DNA repair and radioresponsiveness. Clin Cancer Res. 2014 Nov 1; 20(21):5468-82. PMID: 25165096.
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    44. Park JY, Kricka LJ, Clark P, Londin E, Fortina P. Clinical Genomics: When Whole Genome Sequencing Is like a Whole-body CT Scan. Clin Chem. 2014 Nov; 60(11):1390-2. PMID: 25114273.
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    45. Londin ER, Adijanto J, Philp N, Novelli A, Vitale E, Perria C, Serra G, Alesi V, Surrey S, Fortina P. Donor splice-site mutation in CUL4B is likely cause of X-linked intellectual disability. Am J Med Genet A. 2014 Sep; 164(9):2294-9. PMID: 24898194.
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    46. McDonald MK, Tian Y, Qureshi RA, Gormley M, Ertel A, Gao R, Aradillas Lopez E, Alexander GM, Sacan A, Fortina P, Ajit SK. Functional significance of macrophage-derived exosomes in inflammation and pain. Pain. 2014 Aug; 155(8):1527-39. PMID: 24792623.
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    47. Fortina P, Khaja NA, Ali MT, Hamzeh AR, Nair P, Innocenti F, Patrinos GP, Kricka LJ. Genomics into healthcare: the 5th pan arab human genetics conference and 2013 golden helix symposium. Hum Mutat. 2014 May; 35(5):637-40. PMID: 24526565.
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    48. Londin ER, Hatzimichael E, Loher P, Edelstein L, Shaw C, Delgrosso K, Fortina P, Bray PF, McKenzie SE, Rigoutsos I. The human platelet: strong transcriptome correlations among individuals associate weakly with the platelet proteome. Biol Direct. 2014; 9(1):3. PMID: 24524654.
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    49. Simon LM, Edelstein LC, Nagalla S, Woodley AB, Chen ES, Kong X, Ma L, Fortina P, Kunapuli S, Holinstat M, McKenzie SE, Dong JF, Shaw CA, Bray PF. Human platelet microRNA-mRNA networks associated with age and gender revealed by integrated plateletomics. Blood. 2014 Apr 17; 123(16):e37-45. PMID: 24523238.
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    50. Londin ER, Clark P, Sponziello M, Kricka LJ, Fortina P, Park JY. Performance of exome sequencing for pharmacogenomics. Per Med. 2014; 12(2):109-115. PMID: 26257813.
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    51. Feldman GJ, Parvizi J, Levenstien M, Scott K, Erickson JA, Fortina P, Devoto M, Peters CL. Developmental Dysplasia of the Hip: Linkage Mapping and Whole Exome Sequencing Identify a Shared Variant in CX3CR1 in All Affected Members of a Large Multigeneration Family. J Bone Miner Res. 2013 Dec; 28(12):2540-9. PMID: 23716478.
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    52. Yu Z, Wang L, Wang C, Ju X, Wang M, Chen K, Loro E, Li Z, Zhang Y, Wu K, Casimiro MC, Gormley M, Ertel A, Fortina P, Chen Y, Tozeren A, Liu Z, Pestell RG. Cyclin D1 induction of Dicer governs microRNA processing and expression in breast cancer. Nat Commun. 2013 Nov 29; 4:2812. PMID: 24287487.
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    53. Park JY, Kricka LJ, Fortina P. Next-generation sequencing in the clinic. Nat Biotechnol. 2013 Nov; 31(11):990-2. PMID: 24213773.
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    54. Basile KJ, Abel EV, Dadpey N, Hartsough EJ, Fortina P, Aplin AE. In Vivo MAPK Reporting Reveals the Heterogeneity in Tumoral Selection of Resistance to RAF Inhibitors. Cancer Res. 2013 Dec 1; 73(23):7101-10. PMID: 24121492.
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    55. Pandey AS, San Antonio JD, Addya S, Surrey S, Fortina P, Van Bockstaele EJ, Veznedaroglu E. Mechanisms of endothelial cell attachment, proliferation, and differentiation on 4 types of platinum-based endovascular coils. World Neurosurg. 2014 Nov; 82(5):684-95. PMID: 23994074.
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    56. Zaorsky NG, Sun Y, Wang Z, Palmer J, Fortina PM, Solomides C, Werner-Wasik M, Dicker AP, Axelrod R, Campling B, Evans N, Cowan S, Lu B. Identification of a KRAS mutation in a patient with non-small cell lung cancer treated with chemoradiotherapy and panitumumab. Cancer Biol Ther. 2013 Oct 1; 14(10):883-7. PMID: 23917487.
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    57. Cristofanilli M, Fortina P. Circulating tumor DNA to monitor metastatic breast cancer. N Engl J Med. 2013 Jul 4; 369(1):93-4. PMID: 23822789.
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    58. Park JY, Fortina P, Kricka LJ. Genomic test validation for incidental findings. Clin Chem. 2014 Feb; 60(2):292-3. PMID: 23818443.
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    59. Haddad BR, Gu L, Mirtti T, Dagvadorj A, Vogiatzi P, Hoang DT, Bajaj R, Leiby B, Ellsworth E, Blackmon S, Ruiz C, Curtis M, Fortina P, Ertel A, Liu C, Rui H, Visakorpi T, Bubendorf L, Lallas CD, Trabulsi EJ, McCue P, Gomella L, Nevalainen MT. STAT5A/B Gene Locus Undergoes Amplification during Human Prostate Cancer Progression. Am J Pathol. 2013 Jun; 182(6):2264-75. PMID: 23660011.
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    60. Abel EV, Basile KJ, Kugel CH, Witkiewicz AK, Le K, Amaravadi RK, Karakousis GC, Xu X, Xu W, Schuchter LM, Lee JB, Ertel A, Fortina P, Aplin AE. Melanoma adapts to RAF/MEK inhibitors through FOXD3-mediated upregulation of ERBB3. J Clin Invest. 2013 May 1; 123(5):2155-68. PMID: 23543055.
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    61. Bray PF, McKenzie SE, Edelstein LC, Nagalla S, Delgrosso K, Ertel A, Kupper J, Jing Y, Londin E, Loher P, Chen HW, Fortina P, Rigoutsos I. The complex transcriptional landscape of the anucleate human platelet. BMC Genomics. 2013; 14:1. PMID: 23323973.
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    62. Londin E, Yadav P, Surrey S, Kricka LJ, Fortina P. Use of linkage analysis, genome-wide association studies, and next-generation sequencing in the identification of disease-causing mutations. Methods Mol Biol. 2013; 1015:127-46. PMID: 23824853.
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    63. Thangavel C, Boopathi E, Ertel A, Lim M, Addya S, Fortina P, Witkiewicz AK, Knudsen ES. Regulation of miR106b cluster through the RB pathway: Mechanism and functional targets. Cell Cycle. 2013 Jan 1; 12(1):98-111. PMID: 23255112.
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    65. Ju X, Ertel A, Casimiro MC, Yu Z, Meng H, McCue PA, Walters R, Fortina P, Lisanti MP, Pestell RG. Novel oncogene-induced metastatic prostate cancer cell lines define human prostate cancer progression signatures. Cancer Res. 2013 Jan 15; 73(2):978-89. PMID: 23204233.
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    66. Kricka LJ, Pollak ES, Fortina P. Recent Developments in Miniaturized PCR-Microchips, Microarrays and Microdroplets. EJIFCC. 2012 Oct; 23(3):76-9. PMID: 27683419.
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    67. Mitropoulos K, Innocenti F, van Schaik RH, Lezhava A, Tzimas G, Kollia P, Macek M, Fortina P, Patrinos GP. Institutional Profile: Golden Helix Institute of Biomedical Research: interdisciplinary research and educational activities in pharmacogenomics and personalized medicine. Pharmacogenomics. 2012 Mar; 13(4):387-92. PMID: 22379996.
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    68. Casimiro MC, Crosariol M, Loro E, Ertel A, Yu Z, Dampier W, Saria EA, Papanikolaou A, Stanek TJ, Li Z, Wang C, Fortina P, Addya S, Tozeren A, Knudsen ES, Arnold A, Pestell RG. ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice. J Clin Invest. 2012 Mar 1; 122(3):833-43. PMID: 22307325.
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    69. Danjou F, Anni F, Perseu L, Satta S, Dessì C, Lai ME, Fortina P, Devoto M, Galanello R. Genetic modifiers of ß-thalassemia and clinical severity as assessed by age at first transfusion. Haematologica. 2012 Jul; 97(7):989-93. PMID: 22271886.
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    70. Katiyar S, Jiao X, Addya S, Ertel A, Covarrubias Y, Rose V, Casimiro MC, Zhou J, Lisanti MP, Nasim T, Fortina P, Pestell RG. Mammary gland selective excision of c-jun identifies its role in mRNA splicing. Cancer Res. 2012 Feb 15; 72(4):1023-34. PMID: 22174367.
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    71. Yasuhara R, Ohta Y, Yuasa T, Kondo N, Hoang T, Addya S, Fortina P, Pacifici M, Iwamoto M, Enomoto-Iwamoto M. Roles of ß-catenin signaling in phenotypic expression and proliferation of articular cartilage superficial zone cells. Lab Invest. 2011 Dec; 91(12):1739-52. PMID: 21968810.
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    72. Londin ER, Keller MA, D'Andrea MR, Delgrosso K, Ertel A, Surrey S, Fortina P. Whole-exome sequencing of DNA from peripheral blood mononuclear cells (PBMC) and EBV-transformed lymphocytes from the same donor. BMC Genomics. 2011; 12:464. PMID: 21943378.
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    73. Kricka LJ, Fortina P, Mai Y, Patrinos GP. Direct-access genetic testing: the view from Europe. Nat Rev Genet. 2011 Oct; 12(10):670. PMID: 21915107.
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    74. Witkiewicz AK, Rivadeneira DB, Ertel A, Kline J, Hyslop T, Schwartz GF, Fortina P, Knudsen ES. Association of RB/p16-pathway perturbations with DCIS recurrence: dependence on tumor versus tissue microenvironment. Am J Pathol. 2011 Sep; 179(3):1171-8. PMID: 21756866.
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    75. McClendon AK, Dean JL, Ertel A, Fu Z, Rivadeneira DB, Reed CA, Bourgo RJ, Witkiewicz A, Addya S, Mayhew CN, Grimes HL, Fortina P, Knudsen ES. RB and p53 cooperate to prevent liver tumorigenesis in response to tissue damage. Gastroenterology. 2011 Oct; 141(4):1439-50. PMID: 21704587.
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    76. Villa N, Bentivegna A, Ertel A, Redaelli S, Colombo C, Nacinovich R, Broggi F, Lissoni S, Bungaro S, Addya S, Fortina P, Dalprà L. A de novo supernumerary genomic discontinuous ring chromosome 21 in a child with mild intellectual disability. Am J Med Genet A. 2011 Jun; 155A(6):1425-31. PMID: 21574245.
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    77. Bryant KG, Camacho J, Jasmin JF, Wang C, Addya S, Casimiro MC, Fortina P, Balasubramaniam S, Knudsen KE, Schwarting R, Lisanti MP, Mercier I. Caveolin-1 overexpression enhances androgen-dependent growth and proliferation in the mouse prostate. Int J Biochem Cell Biol. 2011 Sep; 43(9):1318-29. PMID: 21601007.
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    78. Patrinos GP, Innocenti F, Cox N, Fortina P. Genetic Analysis in Translational Medicine: The 2010 GOLDEN HELIX Symposium. Hum Mutat. 2011 Jun; 32(6):698-703. PMID: 21438074.
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    79. Imai K, Kricka LJ, Fortina P. Concordance study of 3 direct-to-consumer genetic-testing services. Clin Chem. 2011 Mar; 57(3):518-21. PMID: 21159896.
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    80. Martinez Cantarin MP, Ertel A, Deloach S, Fortina P, Scott K, Burns TL, Falkner B. Variants in genes involved in functional pathways associated with hypertension in African Americans. Clin Transl Sci. 2010 Dec; 3(6):279-86. PMID: 21167003.
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    81. Del Galdo F, Wermuth PJ, Addya S, Fortina P, Jimenez SA. NF?B activation and stimulation of chemokine production in normal human macrophages by the gadolinium-based magnetic resonance contrast agent Omniscan: possible role in the pathogenesis of nephrogenic systemic fibrosis. Ann Rheum Dis. 2010 Nov; 69(11):2024-33. PMID: 20959327.
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    82. Kricka LJ, Imai K, Fortina P. Analytical ancestry: evolution of the array in analysis. Clin Chem. 2010 Dec; 56(12):1797-803. PMID: 20943847.
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    83. Fortina P, Kricka LJ. Nanotechnology: improving clinical testing? Clin Chem. 2010 Sep; 56(9):1384-9. PMID: 20802097.
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    84. Pavlides S, Tsirigos A, Vera I, Flomenberg N, Frank PG, Casimiro MC, Wang C, Fortina P, Addya S, Pestell RG, Martinez-Outschoorn UE, Sotgia F, Lisanti MP. Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the "reverse Warburg effect": a transcriptional informatics analysis with validation. Cell Cycle. 2010 Jun 1; 9(11):2201-19. PMID: 20519932.
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    85. Gu L, Vogiatzi P, Puhr M, Dagvadorj A, Lutz J, Ryder A, Addya S, Fortina P, Cooper C, Leiby B, Dasgupta A, Hyslop T, Bubendorf L, Alanen K, Mirtti T, Nevalainen MT. Stat5 promotes metastatic behavior of human prostate cancer cells in vitro and in vivo. Endocr Relat Cancer. 2010 Jun; 17(2):481-93. PMID: 20233708.
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    86. Martinoli E, Zuccotti GV, Pogliani L, Volontè M, Venturin M, Fortina P, Ertel A, Redaelli S, Riva P, Dalprà L. A tandem duplication of chromosome 21 in a newborn showing a phenotype inconsistent with Down syndrome. Am J Med Genet A. 2010 Apr; 152A(4):1043-5. PMID: 20358625.
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    87. Saraiya M, Nasser R, Zeng Y, Addya S, Ponnappan RK, Fortina P, Anderson DG, Albert TJ, Shapiro IM, Risbud MV. Reversine enhances generation of progenitor-like cells by dedifferentiation of annulus fibrosus cells. Tissue Eng Part A. 2010 Apr; 16(4):1443-55. PMID: 19947906.
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    88. Gu L, Dagvadorj A, Lutz J, Leiby B, Bonuccelli G, Lisanti MP, Addya S, Fortina P, Dasgupta A, Hyslop T, Bubendorf L, Nevalainen MT. Transcription factor Stat3 stimulates metastatic behavior of human prostate cancer cells in vivo, whereas Stat5b has a preferential role in the promotion of prostate cancer cell viability and tumor growth. Am J Pathol. 2010 Apr; 176(4):1959-72. PMID: 20167868.
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    89. Pavlides S, Whitaker-Menezes D, Castello-Cros R, Flomenberg N, Witkiewicz AK, Frank PG, Casimiro MC, Wang C, Fortina P, Addya S, Pestell RG, Martinez-Outschoorn UE, Sotgia F, Lisanti MP. The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma. Cell Cycle. 2009 Dec; 8(23):3984-4001. PMID: 19923890.
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    90. Liu M, Casimiro MC, Wang C, Shirley LA, Jiao X, Katiyar S, Ju X, Li Z, Yu Z, Zhou J, Johnson M, Fortina P, Hyslop T, Windle JJ, Pestell RG. p21CIP1 attenuates Ras- and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo. Proc Natl Acad Sci U S A. 2009 Nov 10; 106(45):19035-9. PMID: 19858489.
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    91. Bernardini L, Alesi V, Loddo S, Novelli A, Bottillo I, Battaglia A, Digilio MC, Zampino G, Ertel A, Fortina P, Surrey S, Dallapiccola B. High-resolution SNP arrays in mental retardation diagnostics: how much do we gain? Eur J Hum Genet. 2010 Feb; 18(2):178-85. PMID: 19809473.
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    92. Feldman G, Dalsey C, Fertala K, Azimi D, Fortina P, Devoto M, Pacifici M, Parvizi J. The Otto Aufranc Award: Identification of a 4 Mb region on chromosome 17q21 linked to developmental dysplasia of the hip in one 18-member, multigeneration family. Clin Orthop Relat Res. 2010 Feb; 468(2):337-44. PMID: 19756907.
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    93. Levi L, Pekarski I, Gutman E, Fortina P, Hyslop T, Biran J, Levavi-Sivan B, Lubzens E. Revealing genes associated with vitellogenesis in the liver of the zebrafish (Danio rerio) by transcriptome profiling. BMC Genomics. 2009; 10:141. PMID: 19335895.
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    94. Kricka LJ, Fortina P. Analytical ancestry: "firsts" in fluorescent labeling of nucleosides, nucleotides, and nucleic acids. Clin Chem. 2009 Apr; 55(4):670-83. PMID: 19233914.
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    95. Specchia C, Scott K, Fortina P, Devoto M, Falkner B. Association of a polymorphic variant of the adiponectin gene with insulin resistance in african americans. Clin Transl Sci. 2008 Dec; 1(3):194-9. PMID: 20443850.
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    96. Augustus AS, Buchanan J, Gutman E, Rengo G, Pestell RG, Fortina P, Koch WJ, Bensadoun A, Abel ED, Lisanti MP. Hearts lacking caveolin-1 develop hypertrophy with normal cardiac substrate metabolism. Cell Cycle. 2008 Aug 15; 7(16):2509-18. PMID: 18719368.
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    97. Battistella S, Damin F, Chiari M, Delgrosso K, Surrey S, Fortina P, Ferrari M, Cremonesi L. Genotyping beta-globin gene mutations on copolymer-coated glass slides with the ligation detection reaction. Clin Chem. 2008 Oct; 54(10):1657-63. PMID: 18703765.
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    98. Augustus AS, Buchanan J, Addya S, Rengo G, Pestell RG, Fortina P, Koch WJ, Bensadoun A, Abel ED, Lisanti MP. Substrate uptake and metabolism are preserved in hypertrophic caveolin-3 knockout hearts. Am J Physiol Heart Circ Physiol. 2008 Aug; 295(2):H657-66. PMID: 18552160.
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    99. Barbarotto E, Secchiero P, Dasgupta A, Fortina P, Calin GA, Hyslop T. MicroRNAs as new players in the genomic galaxy and disease puzzles. Clin Transl Sci. 2008 May; 1(1):50-6. PMID: 20443818.
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    100. Fortina P, Surrey S. Digital mRNA profiling. Nat Biotechnol. 2008 Mar; 26(3):293-4. PMID: 18327237.
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    101. George RE, Attiyeh EF, Li S, Moreau LA, Neuberg D, Li C, Fox EA, Meyerson M, Diller L, Fortina P, Look AT, Maris JM. Genome-wide analysis of neuroblastomas using high-density single nucleotide polymorphism arrays. PLoS One. 2007; 2(2):e255. PMID: 17327916.
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    102. Fortina P, Kricka LJ, Graves DJ, Park J, Hyslop T, Tam F, Halas N, Surrey S, Waldman SA. Applications of nanoparticles to diagnostics and therapeutics in colorectal cancer. Trends Biotechnol. 2007 Apr; 25(4):145-52. PMID: 17316852.
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    103. Patel P, Shiao YH, Fortina P. Multiplex pyrosequencing for DNA variation analysis. Methods Mol Biol. 2007; 373:75-88. PMID: 17185759.
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    104. Waldman SA, Fortina P, Surrey S, Hyslop T, Kricka LJ, Graves DJ. Opportunities for near-infrared thermal ablation of colorectal metastases by guanylyl cyclase C-targeted gold nanoshells. Future Oncol. 2006 Dec; 2(6):705-16. PMID: 17155897.
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    105. Stewart J, Ware J, Fortina P, Breaux J, Gulati S, Kennedy A. L-selenomethionine modulates high LET radiation-induced alterations of gene expression in cultured human thyroid cells. Oncol Rep. 2006 Sep; 16(3):569-74. PMID: 16865257.
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    106. Schirinzi A, Drmanac S, Dallapiccola B, Huang S, Scott K, De Luca A, Swanson D, Drmanac R, Surrey S, Fortina P. Combinatorial sequencing-by-hybridization: analysis of the NF1 gene. Genet Test. 2006; 10(1):8-17. PMID: 16544997.
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    107. Maris JM, Hii G, Gelfand CA, Varde S, White PS, Rappaport E, Surrey S, Fortina P. Region-specific detection of neuroblastoma loss of heterozygosity at multiple loci simultaneously using a SNP-based tag-array platform. Genome Res. 2005 Aug; 15(8):1168-76. PMID: 16077016.
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    108. Ferraris A, Knafelz D, Torres B, Fortina P, Castro M, Dallapiccola B. Analysis of CARD15 gene variants in Italian pediatric patients with inflammatory bowel diseases. J Pediatr. 2005 Aug; 147(2):272-3. PMID: 16126067.
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    109. Kricka LJ, Park JY, Li SF, Fortina P. Miniaturized detection technology in molecular diagnostics. Expert Rev Mol Diagn. 2005 Jul; 5(4):549-59. PMID: 16013973.
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    110. Fortina P, Kricka LJ, Surrey S, Grodzinski P. Nanobiotechnology: the promise and reality of new approaches to molecular recognition. Trends Biotechnol. 2005 Apr; 23(4):168-73. PMID: 15780707.
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    111. Chen W, Tang Z, Fortina P, Patel P, Addya S, Surrey S, Acheampong EA, Mukhtar M, Pomerantz RJ. Ethanol potentiates HIV-1 gp120-induced apoptosis in human neurons via both the death receptor and NMDA receptor pathways. Virology. 2005 Mar 30; 334(1):59-73. PMID: 15749123.
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    112. Panaro NJ, Lou XJ, Fortina P, Kricka LJ, Wilding P. Micropillar array chip for integrated white blood cell isolation and PCR. Biomol Eng. 2005 Feb; 21(6):157-62. PMID: 15748689.
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    113. Lou XJ, Panaro NJ, Wilding P, Fortina P, Kricka LJ. Mutation detection using ligase chain reaction in passivated silicon-glass microchips and microchip capillary electrophoresis. Biotechniques. 2004 Sep; 37(3):392, 394, 396-8. PMID: 15470893.
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    114. Cowie S, Drmanac S, Swanson D, Delgrosso K, Huang S, du Sart D, Drmanac R, Surrey S, Fortina P. Identification of APC gene mutations in colorectal cancer using universal microarray-based combinatorial sequencing-by-hybridization. Hum Mutat. 2004 Sep; 24(3):261-71. PMID: 15300853.
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    115. Tang Z, McGowan BS, Huber SA, McTiernan CF, Addya S, Surrey S, Kubota T, Fortina P, Higuchi Y, Diamond MA, Wyre DS, Feldman AM. Gene expression profiling during the transition to failure in TNF-alpha over-expressing mice demonstrates the development of autoimmune myocarditis. J Mol Cell Cardiol. 2004 Apr; 36(4):515-30. PMID: 15081311.
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    116. Panaro NJ, Lou XJ, Fortina P, Kricka LJ, Wilding P. Surface effects on PCR reactions in multichip microfluidic platforms. Biomed Microdevices. 2004 Mar; 6(1):75-80. PMID: 15307448.
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    117. Lou XJ, Panaro NJ, Wilding P, Fortina P, Kricka LJ. Increased amplification efficiency of microchip-based PCR by dynamic surface passivation. Biotechniques. 2004 Feb; 36(2):248-52. PMID: 14989089.
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    118. Foglieni B, Cremonesi L, Travi M, Ravani A, Giambona A, Rosatelli MC, Perra C, Fortina P, Ferrari M. Beta-thalassemia microelectronic chip: a fast and accurate method for mutation detection. Clin Chem. 2004 Jan; 50(1):73-9. PMID: 14709638.
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    119. Kricka LJ, Joos T, Fortina P. Protein microarrays: a literature survey. Clin Chem. 2003 Dec; 49(12):2109. PMID: 14633898.
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    120. Palmieri O, Toth S, Ferraris A, Andriulli A, Latiano A, Annese V, Dallapiccola B, Vecchi M, Devoto M, Surrey S, Fortina P. CARD15 genotyping in inflammatory bowel disease patients by multiplex pyrosequencing. Clin Chem. 2003 Oct; 49(10):1675-9. PMID: 14500598.
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    121. Kajiyama T, Miyahara Y, Kricka LJ, Wilding P, Graves DJ, Surrey S, Fortina P. Genotyping on a thermal gradient DNA chip. Genome Res. 2003 Mar; 13(3):467-75. PMID: 12618377.
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    122. Santacroce R, Ratti A, Caroli F, Foglieni B, Ferraris A, Cremonesi L, Margaglione M, Seri M, Ravazzolo R, Restagno G, Dallapiccola B, Rappaport E, Pollak ES, Surrey S, Ferrari M, Fortina P. Analysis of clinically relevant single-nucleotide polymorphisms by use of microelectronic array technology. Clin Chem. 2002 Dec; 48(12):2124-30. PMID: 12446467.
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    123. Kudaravalli R, Tidd T, Pinotti M, Ratti A, Santacroce R, Margaglione M, Dallapiccola B, Bernardi F, Fortina P, Devoto M, Pollak ES. Polymorphic changes in the 5' flanking region of factor VII have a combined effect on promoter strength. Thromb Haemost. 2002 Nov; 88(5):763-7. PMID: 12428091.
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    124. Ferraris A, Rappaport E, Santacroce R, Pollak E, Krantz I, Toth S, Lysholm F, Margaglione M, Restagno G, Dallapiccola B, Surrey S, Fortina P. Pyrosequencing for detection of mutations in the connexin 26 (GJB2) and mitochondrial 12S RNA (MTRNR1) genes associated with hereditary hearing loss. Hum Mutat. 2002 Oct; 20(4):312-20. PMID: 12325027.
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    125. Kricka LJ, Fortina P. Microchips: an all-language literature survey including books and patents. Clin Chem. 2002 Sep; 48(9):1620-2. PMID: 12194954.
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    126. Fortina P, Surrey S, Kricka LJ. Molecular diagnostics: hurdles for clinical implementation. Trends Mol Med. 2002 Jun; 8(6):264-6. PMID: 12067610.
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    127. Su HJ, Surrey S, McKenzie SE, Fortina P, Graves DJ. Kinetics of heterogeneous hybridization on indium tin oxide surfaces with and without an applied potential. Electrophoresis. 2002 May; 23(10):1551-7. PMID: 12116168.
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    128. Kricka LJ, Fortina P, Panaro NJ, Wilding P, Alonso-Amigo G, Becker H. Fabrication of plastic microchips by hot embossing. Lab Chip. 2002 Feb; 2(1):1-4. PMID: 15100847.
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    129. Kricka LJ, Fortina P. Nanotechnology and applications: an all-language literature survey including books and patents. Clin Chem. 2002; 48(4):662-5. PMID: 11901071.
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