Qiaoli Li

TitleProfessor
InstitutionThomas Jefferson University
DepartmentBiochem & Molecular Biology
Address233 S. 10th Street
Philadelphia PA 19107
Phone215-503-5825
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ross CL, Li Q, Uitto J, Keller MS, Ross NA. Iatrogenic Hypertriglyceridemia when Treating Pityriasis Rubra Pilaris: An algorithm for Monitoring and Treatment during Retinoid Therapy. Skinmed. 2024; 22(5):402-403. PMID: 39433533.
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    2. Jacobs IJ, Obiri-Yeboah D, Stabach PR, Braddock DT, Li Q. Novel treatment for PXE: Recombinant ENPP1 enzyme therapy. Mol Ther. 2024 Sep 27. PMID: 39342427.
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    3. Li Q, Troutman C, Peckiconis M, Wurst T, Terry SF. Inorganic pyrophosphate plasma levels in patients with GGCX-associated PXE-like phenotypes. Front Genet. 2024; 15:1429320. PMID: 39399214.
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    4. Sehgal A, Milman T, Li Q, Pulido JS. Histological Findings in the Eyes of Abcc6 Knockout Rat Model of Pseudoxanthoma Elasticum. Transl Vis Sci Technol. 2024 Apr 02; 13(4):29. PMID: 38656313.
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    5. Li Q, Krieger NS, Yang L, Asplin J, Bushinsky DA. Magnesium Decreases Urine Supersaturation but Not Calcium Oxalate Stone Formation in Genetic Hypercalciuric Stone-Forming Rats. Nephron. 2024; 148(7):480-486. PMID: 38262368.
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    6. Jacobs IJ, Li Q. Novel Treatments for PXE: Targeting the Systemic and Local Drivers of Ectopic Calcification. Int J Mol Sci. 2023 Oct 10; 24(20). PMID: 37894722.
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    7. Ralph D, Levine M, Mill?n JL, Uitto J, Li Q. Weighing the evidence for the roles of plasma versus local pyrophosphate in ectopic calcification disorders. J Bone Miner Res. 2023 Feb 20. PMID: 36807615.
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    8. Szeri F, Miko A, Navasiolava N, Kaposi A, Verschuere S, Molnar B, Li Q, Terry SF, Boraldi F, Uitto J, van de Wetering K, Martin L, Quaglino D, Vanakker OM, Tory K, Aranyi T. The pathogenic c.1171A>G (p.Arg391Gly) and c.2359G>A (p.Val787Ile) ABCC6 variants display incomplete penetrance causing pseudoxanthoma elasticum in a subset of individuals. Hum Mutat. 2022 12; 43(12):1872-1881. PMID: 36317459.
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    9. Jacobs IJ, Cheng Z, Ralph D, O'Brien K, Flaman L, Howe J, Thompson D, Uitto J, Li Q, Sabbagh Y. INZ-701, a recombinant ENPP1 enzyme, prevents ectopic calcification in an Abcc6-/- mouse model of pseudoxanthoma elasticum. Exp Dermatol. 2022 May 05. PMID: 35511611.
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    10. Ralph D, Nitschke Y, Levine MA, Caffet M, Wurst T, Saeidian AH, Youssefian L, Vahidnezhad H, Terry SF, Rutsch F, Uitto J, Li Q. ENPP1 variants in patients with GACI and PXE expand the clinical and genetic heterogeneity of heritable disorders of ectopic calcification. PLoS Genet. 2022 04; 18(4):e1010192. PMID: 35482848.
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    11. Ralph D, Levine MA, Richard G, Morrow MM, Flynn EK, Uitto J, Li Q. Mutation update: Variants of the ENPP1 gene in pathologic calcification, hypophosphatemic rickets, and cutaneous hypopigmentation with punctate keratoderma. Hum Mutat. 2022 Apr 27. PMID: 35475527.
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    12. Li Q, Terry SF, Uitto J. Comment on "Clinical practice guidelines for pseudoxanthoma elasticum (2017)": The importance of mutation analysis. J Dermatol. 2022 Mar 22. PMID: 35318717.
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    13. Ralph D, van de Wetering K, Uitto J, Li Q. Inorganic Pyrophosphate Deficiency Syndromes and Potential Treatments for Pathologic Tissue Calcification. Am J Pathol. 2022 Feb 16. PMID: 35182493.
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    14. Huang J, Ralph D, Boraldi F, Quaglino D, Uitto J, Li Q. Inhibition of the DNA Damage Response Attenuates Ectopic Calcification in Pseudoxanthoma Elasticum. J Invest Dermatol. 2022 Feb 07. PMID: 35143822.
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    15. Saeidian AH, Youssefian L, Huang J, Touati A, Vahidnezhad H, Kowal L, Caffet M, Wurst T, Singh J, Snook AE, Ryu E, Fortina P, Terry SF, Schoenecker JG, Uitto J, Li Q. Genetic heterogeneity of heritable ectopic mineralization disorders in a large international cohort. Genet Med. 2022 Jan; 24(1):75-86. PMID: 34906475.
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    16. Kowal L, Huang J, Luo H, Singh J, Snook AE, Uitto J, Li Q. Functional Assessment of Missense Variants in the ABCC6 gene Implicated in Pseudoxanthoma Elasticum, a Heritable Ectopic Mineralization Disorder. J Invest Dermatol. 2021 Sep 28. PMID: 34597610.
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    17. Jacobs IJ, Li D, Ivarsson ME, Uitto J, Li Q. A phytic acid analogue INS-3001 prevents ectopic calcification in an Abcc6-/- mouse model of pseudoxanthoma elasticum. Exp Dermatol. 2021 Feb 01. PMID: 33523493.
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    18. Luo H, Li Q, Cao Y, Uitto J. Therapeutics Development for Pseudoxanthoma Elasticum and Related Ectopic Mineralization Disorders: Update 2020. J Clin Med. 2020 Dec 31; 10(1). PMID: 33396306.
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    19. Luo H, Faghankhani M, Cao Y, Uitto J, Li Q. Molecular Genetics and Modifier Genes in Pseudoxanthoma Elasticum, a Heritable Multisystem Ectopic Mineralization Disorder. J Invest Dermatol. 2020 Dec 16. PMID: 33341249.
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    20. Ralph D, Allawh R, Terry IF, Terry SF, Uitto J, Li Q. Kidney Stones are Prevalent in Individuals with Pseudoxanthoma Elasticum, a Genetic Ectopic Mineralization Disorder. Int J Dermatol Venereol. 2020 Dec; 3(4):198-204. PMID: 34925949.
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    21. Li Q, Philip VM, Stearns TM, Bubier JA, King BL, Low BE, Wiles MV, Saeidian AH, Sundberg BA, Uitto J, Sundberg JP. Quantitative Trait Locus and Integrative Genomics Revealed Candidate Modifier Genes for Ectopic Mineralization in Mouse Models of Pseudoxanthoma Elasticum. J Invest Dermatol. 2019 Jun 15. PMID: 31207231.
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    22. Li Q, Uitto J. Reply to van Gils and Vanakker. J Invest Dermatol. 2019 Jan 17. PMID: 30660667.
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    23. Huang J, Snook AE, Uitto J, Li Q. Adenovirus-mediated ABCC6 Gene Therapy for Heritable Ectopic Mineralization Disorders. J Invest Dermatol. 2019 Jan 10. PMID: 30639429.
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    24. Li Q, Uitto J. Heritable Ectopic Mineralization Disorders: Pathomechanisms and Potential Treatment. J Investig Dermatol Symp Proc. 2018 Dec; 19(2):S106-S107. PMID: 30471751.
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    25. Li Q, van de Wetering K, Uitto J. Pseudoxanthoma Elasticum as a Paradigm of Heritable Ectopic Mineralization Disorders: Pathomechanisms and Treatment Development. Am J Pathol. 2019 Feb; 189(2):216-225. PMID: 30414410.
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    26. Li Q, Uitto J. Zebrafish Models of Ectopic Mineralization-The Paradigm of Pseudoxanthoma Elasticum. J Invest Dermatol. 2018 Nov; 138(11):2301-2304. PMID: 30348334.
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    27. Li Q, Huang J, Pinkerton AB, Millan JL, van Zelst BD, Levine MA, Sundberg JP, Uitto J. Inhibition of Tissue-Nonspecific Alkaline Phosphatase Attenuates Ectopic Mineralization in the Abcc6-/- Mouse Model of PXE but not in the Enpp1 Mutant Mouse Models of GACI. J Invest Dermatol. 2018 Aug 18. PMID: 30130617.
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    28. Li Q, Kingman J, Sundberg JP, Levine MA, Uitto J. Etidronate prevents, but does not reverse, ectopic mineralization in a mouse model of pseudoxanthoma elasticum (Abcc6-/- ). Oncotarget. 2018 Jul 20; 9(56):30721-30730. PMID: 30112102.
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    29. Uitto J, Li Q. Vascular Mineralization in Pseudoxanthoma Elasticum: Etidronate to the Rescue? J Am Coll Cardiol. 2018 Mar 13; 71(10):1127-1129. PMID: 29519354.
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    30. Zhao J, Kingman J, Sundberg JP, Uitto J, Li Q. Plasma PPi Deficiency is the Major, But Not the Exclusive, Cause of Ectopic Mineralization in an Abcc6-/- Mouse Model of PXE. J Invest Dermatol. 2017 Jun 23. PMID: 28652107.
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    31. Kingman J, Uitto J, Li Q. Elevated dietary magnesium during pregnancy and postnatal life prevents ectopic mineralization in Enpp1asj mice, a model for generalized arterial calcification of infancy. Oncotarget. 2017 Jun 13; 8(24):38152-38160. PMID: 28402956.
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    32. Uitto J, Li Q, van de Wetering K, Váradi A, Terry SF. Insights into Pathomechanisms and Treatment Development in Heritable Ectopic Mineralization Disorders: Summary of the PXE International Biennial Research Symposium-2016. J Invest Dermatol. 2017 Apr; 137(4):790-795. PMID: 28340679.
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    33. Li Q, Kingman J, van de Wetering K, Tannouri S, Sundberg JP, Uitto J. Abcc6 Knockout Rat Model Highlights the Role of Liver in PPi Homeostasis in Pseudoxanthoma Elasticum. J Invest Dermatol. 2017 May; 137(5):1025-1032. PMID: 28111129.
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    34. Siu SY, Dyment NA, Rowe DW, Sundberg JP, Uitto J, Li Q. Variable patterns of ectopic mineralization in Enpp1asj-2J mice, a model for generalized arterial calcification of infancy. Oncotarget. 2016 Nov 14. PMID: 27863377.
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    35. Ross NA, Chung HJ, Li Q, Andrews JP, Keller MS, Uitto J. Epidemiologic, Clinicopathologic, Diagnostic, and Management Challenges of Pityriasis Rubra Pilaris: A Case Series of 100 Patients. JAMA Dermatol. 2016 Jun 1; 152(6):670-5. PMID: 26963004.
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    36. Li Q, Berndt A, Sundberg BA, Silva KA, Kennedy VE, Cario CL, Richardson MA, Chase TH, Schofield PN, Uitto J, Sundberg JP. Mouse genome-wide association study identifies polymorphisms on chromosomes 4, 11, and 15 for age-related cardiac fibrosis. Mamm Genome. 2016 Jun; 27(5-6):179-90. PMID: 27126641.
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    37. Zhang J, Dyment NA, Rowe DW, Siu SY, Sundberg JP, Uitto J, Li Q. Ectopic mineralization of cartilage and collagen-rich tendons and ligaments in Enpp1asj-2J mice. Oncotarget. 2016 Mar 15; 7(11):12000-9. PMID: 26910915.
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    38. Li Q, Arányi T, Váradi A, Terry SF, Uitto J. Research Progress in Pseudoxanthoma Elasticum and Related Ectopic Mineralization Disorders. J Invest Dermatol. 2016 Mar; 136(3):550-6. PMID: 26902123.
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    39. Li Q, Kingman J, Sundberg JP, Levine MA, Uitto J. Dual Effects of Bisphosphonates on Ectopic Skin and Vascular Soft Tissue Mineralization versus Bone Microarchitecture in a Mouse Model of Generalized Arterial Calcification of Infancy. J Invest Dermatol. 2016 Jan; 136(1):275-83. PMID: 26763447.
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    40. Li Q, Kingman J, Uitto J. Mineral content of the maternal diet influences ectopic mineralization in offspring of Abcc6(-/-) mice. Cell Cycle. 2015 Oct 2; 14(19):3184-9. PMID: 26199043.
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    41. Li Q, Sundberg JP, Levine MA, Terry SF, Uitto J. The effects of bisphosphonates on ectopic soft tissue mineralization caused by mutations in the ABCC6 gene. Cell Cycle. 2015 Apr 3; 14(7):1082-9. PMID: 25607347.
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    42. South AP, Li Q, Uitto J. Next-generation sequencing for mutation detection in heritable skin diseases: the paradigm of pseudoxanthoma elasticum. J Invest Dermatol. 2015 Apr; 135(4):937-40. PMID: 25785945.
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    43. Li Q, Jin Chung H, Ross N, Keller M, Andrews J, Kingman J, Sarig O, Fuchs-Telem D, Sprecher E, Uitto J. Analysis of CARD14 Polymorphisms in Pityriasis Rubra Pilaris: Activation of NF-?B. J Invest Dermatol. 2015 Jul; 135(7):1905-8. PMID: 25734815.
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    44. Youssefian L, Vahidnezhad H, Daneshpazhooh M, Abdollahzadeh S, Talari H, Khoshnevisan A, Chams-Davatchi C, Mobasher R, Li Q, Uitto J, Akhondzadeh S, Tabrizi M. Lipoid proteinosis: phenotypic heterogeneity in Iranian families with c.507delT mutation in ECM1. Exp Dermatol. 2015 Mar; 24(3):220-2. PMID: 25529926.
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    45. Youssefian L, Vahidnezhad H, Baghdadi T, Ghaznavi A, Li Q, Tabrizi M, Uitto J. Fibroadipose Hyperplasia versus Proteus Syndrome: Segmental Overgrowth with a Mosaic Mutation in the PIK3CA Gene. J Invest Dermatol. 2015 May; 135(5):1450-3. PMID: 25602158.
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    46. Youssefian L, Vahidnezhad H, Barzegar M, Li Q, Sotoudeh S, Yazdanfar A, Ehsani AH, Kajbafzadeh AM, Mozafari N, Ebrahimi Daryani N, Agha-Hosseini F, Zeinali S, Uitto J. The Kindler Syndrome: A Spectrum of FERMT1 Mutations in Iranian Families. J Invest Dermatol. 2015 May; 135(5):1447-50. PMID: 25599393.
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    47. Li Q, Pratt CH, Dionne LA, Fairfield H, Karst SY, Sundberg JP, Uitto J. Spontaneous asj-2J Mutant Mouse as a Model for Generalized Arterial Calcification of Infancy: A Large Deletion/Insertion Mutation in the Enpp1 Gene. PLoS One. 2014; 9(12):e113542. PMID: 25479107.
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    48. Li Q, Price TP, Sundberg JP, Uitto J. Juxta-articular joint-capsule mineralization in CD73 deficient mice: Similarities to patients with NT5E mutations. Cell Cycle. 2014 Aug 15; 13(16):2609-15. PMID: 25486201.
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    49. Li Q, Uitto J. Zebrafish as a model system to study skin biology and pathology. J Invest Dermatol. 2014 Jun; 134(6):e21. PMID: 24825064.
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    50. Li Q, Chou DW, Price TP, Sundberg JP, Uitto J. Genetic modulation of nephrocalcinosis in mouse models of ectopic mineralization: the Abcc6(tm1Jfk) and Enpp1(asj) mutant mice. Lab Invest. 2014 Jun; 94(6):623-32. PMID: 24732453.
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    51. Li Q, Guo H, Chou DW, Berndt A, Sundberg JP, Uitto J. Mouse models for pseudoxanthoma elasticum: genetic and dietary modulation of the ectopic mineralization phenotypes. PLoS One. 2014; 9(2):e89268. PMID: 24586646.
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    52. Li Q, Brodsky JL, Conlin LK, Pawel B, Glatz AC, Gafni RI, Schurgers L, Uitto J, Hakonarson H, Deardorff MA, Levine MA. Mutations in the ABCC6 Gene as a Cause of Generalized Arterial Calcification of Infancy: Genotypic Overlap with Pseudoxanthoma Elasticum. J Invest Dermatol. 2014 Mar; 134(3):658-65. PMID: 24008425.
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    53. Li Q, Jiang Q, Uitto J. Ectopic mineralization disorders of the extracellular matrix of connective tissue: molecular genetics and pathomechanisms of aberrant calcification. Matrix Biol. 2014 Jan; 33:23-8. PMID: 23891698.
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    54. Guo H, Li Q, Chou DW, Uitto J. Atorvastatin counteracts aberrant soft tissue mineralization in a mouse model of pseudoxanthoma elasticum (Abcc6?/?). J Mol Med (Berl). 2013 Oct; 91(10):1177-84. PMID: 23807484.
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    55. Li Q, Guo H, Chou DW, Berndt A, Sundberg JP, Uitto J. Mutant Enpp1asj mice as a model for generalized arterial calcification of infancy. Dis Model Mech. 2013 Sep-Oct; 6(5):1227-35. PMID: 23798568.
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    56. Li Q, Uitto J. Mineralization/Anti-mineralization networks in the skin and vascular connective tissues. Am J Pathol. 2013 Jul; 183(1):10-8. PMID: 23665350.
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    57. Li Q, Guo H, Chou DW, Harrington DJ, Schurgers LJ, Terry SF, Uitto J. Warfarin accelerates ectopic mineralization in abcc6(-/-) mice: clinical relevance to pseudoxanthoma elasticum. Am J Pathol. 2013 Apr; 182(4):1139-50. PMID: 23415960.
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    58. Li Q, Uitto J. Zebrafish as a model system to study heritable skin diseases. Methods Mol Biol. 2013; 961:411-24. PMID: 23325661.
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    59. Li Q, Uitto J. Heritable ectopic mineralization disorders: the paradigm of pseudoxanthoma elasticum. J Invest Dermatol. 2012; 132(E1):E15-9. PMID: 23154625.
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    60. Li Q, Uitto J. Heritable Ectopic Mineralization Disorders: The Paradigm of Pseudoxanthoma Elasticum. J Invest Dermatol. 2012 Nov; 132 Suppl 3:E15-9. PMID: 26875435.
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    61. Uitto J, Li Q, Urban Z. The complexity of elastic fibre biogenesis in the skin - a perspective to the clinical heterogeneity of cutis laxa. Exp Dermatol. 2013 Feb; 22(2):88-92. PMID: 23088642.
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    62. Li Q, Berndt A, Guo H, Sundberg JP, Uitto J. A novel animal model for pseudoxanthoma elasticum: the KK/HlJ mouse. Am J Pathol. 2012 Oct; 181(4):1190-6. PMID: 22846719.
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    63. Kupetsky-Rincon EA, Li Q, Uitto J. Magnesium reduces carotid intima-media thickness in a mouse model of pseudoxanthoma elasticum: a novel treatment biomarker. Clin Transl Sci. 2012 Jun; 5(3):259-64. PMID: 22686203.
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    64. Li Q, Frank M, Akiyama M, Shimizu H, Ho SY, Thisse C, Thisse B, Sprecher E, Uitto J. Abca12-mediated lipid transport and Snap29-dependent trafficking of lamellar granules are crucial for epidermal morphogenesis in a zebrafish model of ichthyosis. Dis Model Mech. 2011 Nov; 4(6):777-85. PMID: 21816950.
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    65. Jiang Q, Quaynor B, Sun A, Li Q, Matsui H, Honda H, Inaba T, Sprecher E, Uitto J. The Samd9L gene: transcriptional regulation and tissue-specific expression in mouse development. J Invest Dermatol. 2011 Jul; 131(7):1428-34. PMID: 21412262.
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    66. LaRusso J, Li Q, Uitto J. Pseudoxanthoma elasticum, the paradigm of heritable ectopic mineralization disorders - can diet help? J Dtsch Dermatol Ges. 2011 Aug; 9(8):586-93. PMID: 21435181.
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    67. Jiang Q, Li Q, Grand-Pierre AE, Schurgers LJ, Uitto J. Administration of vitamin K does not counteract the ectopic mineralization of connective tissues in Abcc6 (-/-) mice, a model for pseudoxanthoma elasticum. Cell Cycle. 2011 Feb 15; 10(4):701-7. PMID: 21304270.
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    68. Li Q, Frank M, Thisse CI, Thisse BV, Uitto J. Zebrafish: a model system to study heritable skin diseases. J Invest Dermatol. 2011 Mar; 131(3):565-71. PMID: 21191402.
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    69. Li Q, Sadowski S, Frank M, Chai C, Váradi A, Ho SY, Lou H, Dean M, Thisse C, Thisse B, Uitto J. The abcc6a gene expression is required for normal zebrafish development. J Invest Dermatol. 2010 Nov; 130(11):2561-8. PMID: 20596085.
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    70. Uitto J, Li Q, Jiang Q. Pseudoxanthoma elasticum: molecular genetics and putative pathomechanisms. J Invest Dermatol. 2010 Mar; 130(3):661-70. PMID: 20032990.
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    71. Li Q, Larusso J, Grand-Pierre AE, Uitto J. Magnesium carbonate-containing phosphate binder prevents connective tissue mineralization in Abcc6(-/-) mice-potential for treatment of pseudoxanthoma elasticum. Clin Transl Sci. 2009 Dec; 2(6):398-404. PMID: 20443931.
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    72. Li Q, Uitto J. The mineralization phenotype in Abcc6 ( -/- ) mice is affected by Ggcx gene deficiency and genetic background--a model for pseudoxanthoma elasticum. J Mol Med (Berl). 2010 Feb; 88(2):173-81. PMID: 19784827.
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    73. LaRusso J, Li Q, Jiang Q, Uitto J. Elevated dietary magnesium prevents connective tissue mineralization in a mouse model of pseudoxanthoma elasticum (Abcc6(-/-)). J Invest Dermatol. 2009 Jun; 129(6):1388-94. PMID: 19122649.
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    74. Li Q, Schurgers LJ, Smith AC, Tsokos M, Uitto J, Cowen EW. Co-existent pseudoxanthoma elasticum and vitamin K-dependent coagulation factor deficiency: compound heterozygosity for mutations in the GGCX gene. Am J Pathol. 2009 Feb; 174(2):534-40. PMID: 19116367.
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    75. Li Q, Jiang Q, Pfendner E, Váradi A, Uitto J. Pseudoxanthoma elasticum: clinical phenotypes, molecular genetics and putative pathomechanisms. Exp Dermatol. 2009 Jan; 18(1):1-11. PMID: 19054062.
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    76. Li Q, Grange DK, Armstrong NL, Whelan AJ, Hurley MY, Rishavy MA, Hallgren KW, Berkner KL, Schurgers LJ, Jiang Q, Uitto J. Mutations in the GGCX and ABCC6 genes in a family with pseudoxanthoma elasticum-like phenotypes. J Invest Dermatol. 2009 Mar; 129(3):553-63. PMID: 18800149.
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    77. Li Q, Jiang Q, Uitto J. Pseudoxanthoma elasticum: oxidative stress and antioxidant diet in a mouse model (Abcc6-/-). J Invest Dermatol. 2008 May; 128(5):1160-4. PMID: 18049453.
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    78. LaRusso J, Jiang Q, Li Q, Uitto J. Ectopic mineralization of connective tissue in Abcc6-/- mice: effects of dietary modifications and a phosphate binder--a preliminary study. Exp Dermatol. 2008 Mar; 17(3):203-7. PMID: 17979973.
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    79. Li Q, Jiang Q, Schurgers LJ, Uitto J. Pseudoxanthoma elasticum: reduced gamma-glutamyl carboxylation of matrix gla protein in a mouse model (Abcc6-/-). Biochem Biophys Res Commun. 2007 Dec 14; 364(2):208-13. PMID: 17942075.
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    80. Li Q, Jiang Q, Larusso J, Klement JF, Sartorelli AC, Belinsky MG, Kruh GD, Uitto J. Targeted ablation of Abcc1 or Abcc3 in Abcc6(-/-) mice does not modify the ectopic mineralization process. Exp Dermatol. 2007 Oct; 16(10):853-9. PMID: 17845218.
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    81. Jiang Q, Li Q, Uitto J. Aberrant mineralization of connective tissues in a mouse model of pseudoxanthoma elasticum: systemic and local regulatory factors. J Invest Dermatol. 2007 Jun; 127(6):1392-402. PMID: 17273159.
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