Thomas Jefferson University

Raymond Penn

TitleProfessor
InstitutionThomas Jefferson University
DepartmentCenter for Translational Medic
Address1020 Locust St.
Philadelphia PA 19107
Phone215-955-9982
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    Collapse Biography 
    Collapse awards and honors
    1985 - 1986Russell Conwell Fellowship, Temple University
    1988Phi Delta Gamma Award, Temple School of Medicine
    1993Clinical Research Trainee Award, Thomas Jefferson University
    1993 - 1995NRSA Fellowship Award, Thomas Jefferson University
    2002 - 2005ALA Career Investigator Award, American Lung Association
    2207Special Friend of Internal Medicine Residency Program , Wake Forest School of Medicine
    2007Star Reviewer American Physiological Society, American Physiological Society
    2012Rehfuss Lecturer, Thomas Jefferson University

    Collapse Research 
    Collapse research activities and funding
    F32HL008831     (PENN, RAYMOND B.)Sep 6, 1993
    NIH
    EPITHELIAL BETA-ADRENOCEPTOR ADENYLYL CYCLASE REGULATION
    Role: Principal Investigator
    R29HL058506     (PENN, RAYMOND B.)Aug 1, 1997 - Jul 31, 2002
    NIH
    BETA ADRENERGIC RECEPTOR REGULATION IN HUMAN AIRWAY MUSC
    Role: Principal Investigator
    R01HL058506     (PENN, RAYMOND B.)Aug 1, 1997 - Jul 31, 2028
    NIH
    G Protein-Coupled Receptor Regulation in Airway Myocytes
    Role: Principal Investigator
    R01HL065338     (PENN, RAYMOND B.)Jun 10, 2001 - May 31, 2006
    NIH
    Human Airway Smooth Muscle Growth Regulation
    Role: Principal Investigator
    R01AI059755     (PENN, RAYMOND B.)Mar 15, 2004 - Feb 28, 2010
    NIH
    Regulation of cysteinyl leukotriene type i receptor
    Role: Principal Investigator
    R01HL093103     (PENN, RAYMOND B.)Jul 1, 2010 - Oct 30, 2014
    NIH
    Arrestin Selectivity for GPCRs in Airway Smooth Muscle
    Role: Principal Investigator
    R21HL108071     (PENN, RAYMOND B.)Jun 1, 2011 - Mar 31, 2013
    NIH
    OGR1 is a proton-sensing GPCR in airway smooth muscle
    Role: Principal Investigator
    R01AI110007     (WALKER, JULIA K L)Jun 18, 2014 - Nov 30, 2020
    NIH
    Optimizing Beta-Adrenoceptor Signaling Bias in Asthma
    Role: Co-Principal Investigator
    R01HL136209     (PENN, RAYMOND B.)Feb 1, 2017 - Jan 31, 2021
    NIH
    Optimizing EP receptor subtype targeting for asthma therapy
    Role: Principal Investigator
    R01HL145392     (KRISHNAN, RAMASWAMY ;PENN, RAYMOND B. ;TANG, DALE D.)Aug 1, 2019 - Jun 30, 2024
    NIH
    Cooperative targeting of pharmacomechanical coupling and the actin cytoskeleton to regulate ASM contraction
    Role: Principal Investigator
    R01AI161296     (WALKER, JULIA K L)Mar 15, 2021 - Feb 28, 2026
    NIH
    Novel Biased Beta2-AR Ligands as Asthma Therapeutics
    Role: Co-Principal Investigator
    R01HL169522     (RICH, THOMAS C)Jul 1, 2023 - Jun 30, 2027
    NIH
    Compartmentalized signaling and crosstalk in airway myocytes
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Jannu AK, Penn RB. Channeling Relaxation through Multiple Means: TMEM16A Antagonism for Asthma. Am J Respir Cell Mol Biol. 2024 Nov 26. PMID: 39589219.
      Citations:    
    2. Javed E, Nayak AP, Jannu AK, Cohen AH, Dewes I, Wang R, Tang DD, Deshpande DA, Penn RB. A-Kinase-Anchoring-Protein Subtypes Differentially Regulate GPCR Signaling and Function in Human Airway Smooth Muscle. Am J Respir Cell Mol Biol. 2024 Aug 14. PMID: 39141573.
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    3. Conaway S, Huang W, Hernandez-Lara MA, Kane MA, Penn RB, Deshpande DA. Molecular mechanism of bitter taste receptor agonist-mediated relaxation of airway smooth muscle. FASEB J. 2024 Jul 31; 38(14):e23842. PMID: 39037554.
      Citations:    
    4. Liao G, Wang R, Wu Y, Maheshwari NK, Penn RB, Tang DD. Nestin drives allergen-induced airway smooth muscle hyperplasia and airway remodeling. Allergy. 2023 Oct 27. PMID: 37897062.
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    5. Deshpande DA, Penn RB. ROS Behaving Badly: Oxidized Phosphatidylcholines Corrupt Ca2+ Signaling in Airway Smooth Muscle. Am J Respir Cell Mol Biol. 2023 Sep 06. PMID: 37672671.
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    6. Tompkins E, Mimic B, Penn RB, Pera T. The biased M3 mAChR ligand PD 102807 mediates qualitatively distinct signaling to regulate airway smooth muscle phenotype. J Biol Chem. 2023 Sep 01; 105209. PMID: 37660916.
      Citations:    
    7. Nayak AP, Javed E, Villalba DR, Wang Y, Morelli HP, Shah SD, Kim N, Ostrom RS, Panettieri RA, An SS, Tang DD, Penn RB. Pro-Relaxant EP Receptors Functionally Partition to Different Pro-Contractile Receptors in Airway Smooth Muscle. Am J Respir Cell Mol Biol. 2023 Jul 31. PMID: 37523713.
      Citations:    
    8. Ippolito M, De Pascali F, Hopfinger N, Komolov KE, Laurinavichyute D, Reddy PAN, Sakkal LA, Rajkowski KZ, Nayak AP, Lee J, Lee J, Cao G, Donover PS, Reichman M, An SS, Salvino JM, Penn RB, Armen RS, Scott CP, Benovic JL. Identification of a ?-arrestin-biased negative allosteric modulator for the ?2-adrenergic receptor. Proc Natl Acad Sci U S A. 2023 08; 120(31):e2302668120. PMID: 37490535.
      Citations:    
    9. Hernandez-Lara MA, Yadav SK, Conaway S, Shah SD, Penn RB, Deshpande DA. Crosstalk between diacylglycerol kinase and protein kinase A in the regulation of airway smooth muscle cell proliferation. Respir Res. 2023 Jun 10; 24(1):155. PMID: 37301818.
      Citations:    
    10. Parker M, Annamdevula NS, Pleshinger D, Ijaz Z, Jalkh J, Penn R, Deshpande D, Rich TC, Leavesley SJ. Comparing Performance of Spectral Image Analysis Approaches for Detection of Cellular Signals in Time-Lapse Hyperspectral Imaging Fluorescence Excitation-Scanning Microscopy. Bioengineering (Basel). 2023 May 25; 10(6). PMID: 37370573.
      Citations:    
    11. Ahn K, Penn RB, Rattan S, Panettieri RA, Voight BF, An SS. Mendelian Randomization Analysis Reveals a Complex Genetic Interplay among Atopic Dermatitis, Asthma, and Gastroesophageal Reflux Disease. Am J Respir Crit Care Med. 2023 01 15; 207(2):130-137. PMID: 36214830.
      Citations:    
    12. Shah SD, Lind C, De Pascali F, Penn RB, MacKerell AD, Deshpande DA. In silico identification of a ?2-adrenoceptor allosteric site that selectively augments canonical ?2AR-Gs signaling and function. Proc Natl Acad Sci U S A. 2022 12 06; 119(49):e2214024119. PMID: 36449547.
      Citations:    
    13. Tompkins E, Mimic B, Cuevas-Mora K, Schorsch H, Shah SD, Deshpande DA, Benovic JL, Penn RB, Pera T. PD 102807 Induces M3 mAChR-Dependent GRK-/Arrestin-Biased Signaling in Airway Smooth Muscle Cells. Am J Respir Cell Mol Biol. 2022 11; 67(5):550-561. PMID: 35944139.
      Citations:    
    14. Hernandez-Lara MA, Yadav SK, Shah SD, Okumura M, Yokoyama Y, Penn RB, Kambayashi T, Deshpande DA. Regulation of Airway Smooth Muscle Cell Proliferation by Diacylglycerol Kinase: Relevance to Airway Remodeling in Asthma. Int J Mol Sci. 2022 Oct 06; 23(19). PMID: 36233170.
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    15. Deshpande DA, Penn RB. A cryptic mode of GPCR regulation revealed. Trends Mol Med. 2022 Nov; 28(11):900-901. PMID: 36109317.
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    16. Howard M, Annamdevula N, Pleshinger DJ, Johnson S, Beech L, Penn RB, Francis CM, Rich TC, Leavesley SJ. Novel Hyperspectral imaging approaches allow 3D measurement of cAMP signals in localized subcellular domains of human airway smooth muscle cells. Proc SPIE Int Soc Opt Eng. 2022 Jan-Feb; 11964. PMID: 35755607.
      Citations:    
    17. Wang R, Wang Y, Liao G, Chen B, Panettieri RA, Penn RB, Tang DD. Abi1 mediates airway smooth muscle cell proliferation and airway remodeling via Jak2/STAT3 signaling. iScience. 2022 Feb 18; 25(2):103833. PMID: 35198891.
      Citations:    
    18. Nayak AP, Deshpande DA, Shah SD, Villalba DR, Yi R, Wang N, Penn RB. OGR1-dependent regulation of the allergen-induced asthma phenotype. Am J Physiol Lung Cell Mol Physiol. 2021 Oct 20. PMID: 34668419.
      Citations:    
    19. Sharma P, Yadav SK, Shah SD, Javed E, Lim JM, Pan S, Nayak AP, Panettieri RA, Penn RB, Kambayashi T, Deshpande DA. Diacylglycerol Kinase Inhibition Reduces Airway Contraction by Negative Feedback Regulation of Gq-signaling. Am J Respir Cell Mol Biol. 2021 Jul 22. PMID: 34293268.
      Citations:    
    20. Yadav SK, Sharma P, Shah SD, Panettieri RA, Kambayashi T, Penn RB, Deshpande DA. Autocrine regulation of airway smooth muscle contraction by diacylglycerol kinase. J Cell Physiol. 2021 Jul 18. PMID: 34278583.
      Citations:    
    21. Nayak AP, Lim JM, Arbel E, Wang R, Villalba DR, Nguyen TL, Schaible N, Krishnan R, Tang DD, Penn RB. Cooperativity between ß-agonists and c-Abl inhibitors in regulating airway smooth muscle relaxation. FASEB J. 2021 07; 35(7):e21674. PMID: 34115899.
      Citations:    
    22. Penn RB. Honing in on the effectors of oxidative stress in the asthmatic lung: oxidised phosphatidylcholines. Eur Respir J. 2021 Feb; 57(2). PMID: 33602878.
      Citations:    
    23. Sharma P, Penn RB. Can GPCRs Be Targeted to Control Inflammation in Asthma? Adv Exp Med Biol. 2021; 1304:1-20. PMID: 34019260.
      Citations:    
    24. Krymskaya VP, Penn RB. Enlightening Ways to Relax Airway Smooth Muscle: Opsins. Am J Respir Cell Mol Biol. 2021 Jan; 64(1):4-6. PMID: 33166477.
      Citations:    
    25. Huang J, Lam H, Koziol-White C, Limjunyawong N, Kim D, Kim N, Karmacharya N, Rajkumar P, Firer D, Dalesio NM, Jude J, Kurten RC, Pluznick JL, Deshpande DA, Penn RB, Liggett SB, Panettieri RA, Dong X, An SS. The odorant receptor OR2W3 on airway smooth muscle evokes bronchodilation via a cooperative chemosensory tradeoff between TMEM16A and CFTR. Proc Natl Acad Sci U S A. 2020 11 10; 117(45):28485-28495. PMID: 33097666.
      Citations:    
    26. Penn RB. Mast cells in asthma: Here I am, stuck in the middle with you. Eur Respir J. 2020 Jul; 56(1). PMID: 32616549.
      Citations:    
    27. Nayak AP, Penn RB. The proton-sensing receptor ovarian cancer G-protein coupled receptor 1 (OGR1) in airway physiology and disease. Curr Opin Pharmacol. 2020 Apr 29; 51:1-10. PMID: 32361614.
      Citations:    
    28. Chan TO, Armen RS, Yadav S, Shah S, Zhang J, Tiegs BC, Keny N, Blumhof B, Deshpande DA, Rodeck U, Penn RB. A tripartite cooperative mechanism confers resistance of the protein kinase A catalytic subunit to dephosphorylation. J Biol Chem. 2020 Jan 21. PMID: 31964716.
      Citations:    
    29. Nunez FJ, Schulte NA, Fogel DM, Michalski J, Rennard SI, Penn RB, Toews ML, Ostrom RS. Agonist-specific desensitization of PGE2-stimulated cAMP signaling due to upregulated phosphodiesterase expression in human lung fibroblasts. Naunyn Schmiedebergs Arch Pharmacol. 2019 Dec 28. PMID: 31884570.
      Citations:    
    30. Javed E, Thangavel C, Frara N, Singh J, Mohanty I, Hypolite J, Birbe R, Braverman AS, Den RB, Rattan S, Zderic SA, Deshpande DA, Penn RB, Ruggieri MR, Chacko S, Boopathi E. Increased expression of desmin and vimentin reduces bladder smooth muscle contractility via JNK2. FASEB J. 2019 Dec 16. PMID: 31909533.
      Citations:    
    31. Foster SR, Hauser AS, Vedel L, Strachan RT, Huang XP, Gavin AC, Shah SD, Nayak AP, Haugaard-Kedström LM, Penn RB, Roth BL, Bräuner-Osborne H, Gloriam DE. Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors. Cell. 2019 Oct 31; 179(4):895-908.e21. PMID: 31675498.
      Citations:    
    32. Pera T, Tompkins E, Katz M, Wang B, Deshpande DA, Weinman EJ, Penn RB. Specificity of NHERF1 regulation of GPCR signaling and function in human airway smooth muscle. FASEB J. 2019 May 01; fj201900323R. PMID: 31042404.
      Citations:    
    33. Nayak AP, Pera T, Deshpande DA, Michael JV, Liberato JR, Pan S, Tompkins E, Morelli HP, Yi R, Wang N, Penn RB. Regulation of Ovarian cancer G protein-coupled receptor (OGR1) expression and signaling. Am J Physiol Lung Cell Mol Physiol. 2019 Feb 06. PMID: 30724097.
      Citations:    
    34. Thangavel C, Gomes CM, Zderic SA, Javed E, Addya S, Singh J, Das S, Birbe R, Den RB, Rattan S, Deshpande DA, Penn RB, Chacko S, Boopathi E. NF-?B and GATA-6 Repress Transcription of Caveolins in Bladder Smooth Muscle Hypertrophy. Am J Pathol. 2019 Jan 29. PMID: 30707892.
      Citations:    
    35. Michael JV, Gavrila A, Nayak AP, Pera T, Liberato JR, Polischak SR, Shah SD, Deshpande DA, Penn RB. Cooperativity of E-prostanoid receptor subtypes in regulating signaling and growth inhibition in human airway smooth muscle. FASEB J. 2019 Jan 02; fj201801959R. PMID: 30601680.
      Citations:    
    36. Pera T, Penn RB. Methods to Investigate ß-Arrestin-Mediated Regulation of GPCR Function in Human Airway Smooth Muscle. Methods Mol Biol. 2019; 1957:69-82. PMID: 30919347.
      Citations:    
    37. Yadav SK, Shah SD, Penn RB. Give Me a Fork: Can Autophagy Research Solve the Riddle of Airway Remodeling in Asthma? Am J Respir Cell Mol Biol. 2018 Nov 13. PMID: 30423254.
      Citations:    
    38. Nayak AP, Deshpande DA, Penn RB. New targets for resolution of airway remodeling in obstructive lung diseases. F1000Res. 2018; 7. PMID: 29904584.
      Citations:    
    39. Panettieri RA, Pera T, Liggett SB, Benovic JL, Penn RB. Pepducins as a potential treatment strategy for asthma and COPD. Curr Opin Pharmacol. 2018 Jun; 40:120-125. PMID: 29729548.
      Citations:    
    40. Pera T, Deshpande DA, Ippolito M, Wang B, Gavrila A, Michael JV, Nayak AP, Tompkins E, Farrell E, Kroeze WK, Roth BL, Panettieri RA, Benovic JL, An SS, Dulin NO, Penn RB. Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines. FASEB J. 2018 Feb; 32(2):862-874. PMID: 29042451.
      Citations:    
    41. Yoo EJ, Cao G, Koziol-White CJ, Ojiaku CA, Sunder K, Jude JA, Michael JV, Lam H, Pushkarsky I, Damoiseaux R, Di Carlo D, Ahn K, An SS, Penn RB, Panettieri RA. Ga12 facilitates shortening in human airway smooth muscle by modulating phosphoinositide 3-kinase-mediated activation in a RhoA-dependent manner. Br J Pharmacol. 2017 Dec; 174(23):4383-4395. PMID: 28921504.
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    42. Singh J, Mohanty I, Addya S, Phillips B, Mee Yong H, An SS, Penn RB, Rattan S. Role of differentially expressed microRNA-139-5p in the regulation of phenotypic internal anal sphincter smooth muscle tone. Sci Rep. 2017 May 03; 7(1):1477. PMID: 28469189.
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    43. Prakash YS, Halayko AJ, Gosens R, Panettieri RA, Camoretti-Mercado B, Penn RB. An Official American Thoracic Society Research Statement: Current Challenges Facing Research and Therapeutic Advances in Airway Remodeling. Am J Respir Crit Care Med. 2017 Jan 15; 195(2):e4-e19. PMID: 28084822.
      Citations:    
    44. Billington CK, Penn RB, Hall IP. ß2 Agonists. Handb Exp Pharmacol. 2016 Nov 23. PMID: 27878470.
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    45. Singh J, Boopathi E, Addya S, Phillips B, Rigoutsos I, Penn RB, Rattan S. Aging-associated changes in microRNA expression profile of internal anal sphincter smooth muscle: Role of microRNA-133a. Am J Physiol Gastrointest Liver Physiol. 2016 Nov 01; 311(5):G964-G973. PMID: 27634012.
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    46. Forkuo GS, Kim H, Thanawala VJ, Al-Sawalha N, Valdez D, Joshi R, Parra S, Pera T, Gonnella PA, Knoll BJ, Walker JK, Penn RB, Bond RA. Phosphodiesterase 4 Inhibitors Attenuate the Asthma Phenotype Produced by ß2-Adrenoceptor Agonists in Phenylethanolamine N-Methyltransferase-Knockout Mice. Am J Respir Cell Mol Biol. 2016 Aug; 55(2):234-42. PMID: 26909542.
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    47. Pera T, Penn RB. Bronchoprotection and bronchorelaxation in asthma: New targets, and new ways to target the old ones. Pharmacol Ther. 2016 Aug; 164:82-96. PMID: 27113408.
      Citations:    
    48. Huang XP, Karpiak J, Kroeze WK, Zhu H, Chen X, Moy SS, Saddoris KA, Nikolova VD, Farrell MS, Wang S, Mangano TJ, Deshpande DA, Jiang A, Penn RB, Jin J, Koller BH, Kenakin T, Shoichet BK, Roth BL. Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65. Nature. 2015 Nov 26; 527(7579):477-83. PMID: 26550826.
      Citations:    
    49. Chan TO, Zhang J, Tiegs BC, Blumhof B, Yan L, Keny N, Penny M, Li X, Pascal JM, Armen RS, Rodeck U, Penn RB. Akt kinase C-terminal modifications control activation loop dephosphorylation and enhance insulin response. Biochem J. 2015 Oct 1; 471(1):37-51. PMID: 26201515.
      Citations:    
    50. Romero F, Shah D, Duong M, Penn RB, Fessler MB, Madenspacher J, Stafstrom W, Kavuru M, Lu B, Kallen CB, Walsh K, Summer R. A Pneumocyte-Macrophage Paracrine Lipid Axis Drives the Lung toward Fibrosis. Am J Respir Cell Mol Biol. 2015 Jul; 53(1):74-86. PMID: 25409201.
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    51. Pera T, Hegde A, Deshpande DA, Morgan SJ, Tiegs BC, Theriot BS, Choi YH, Walker JK, Penn RB. Specificity of arrestin subtypes in regulating airway smooth muscle G protein-coupled receptor signaling and function. FASEB J. 2015 Oct; 29(10):4227-35. PMID: 26103985.
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    52. Penn RB. Physiology. Calcilytics for asthma relief. Science. 2015 Apr 24; 348(6233):398-9. PMID: 25908810.
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    53. Morgan SJ, Deshpande DA, Tiegs BC, Misior AM, Yan H, Hershfeld AV, Rich TC, Panettieri RA, An SS, Penn RB. ß-Agonist-mediated Relaxation of Airway Smooth Muscle Is Protein Kinase A-dependent. J Biol Chem. 2014 Aug 15; 289(33):23065-74. PMID: 24973219.
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    54. Pera T, Penn RB. Crosstalk between beta-2-adrenoceptor and muscarinic acetylcholine receptors in the airway. Curr Opin Pharmacol. 2014 Jun; 16:72-81. PMID: 24747364.
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    55. Penn RB. Far from "disappointing". Am J Respir Crit Care Med. 2014 Feb 1; 189(3):360. PMID: 24484334.
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    56. Penn RB, Bond RA, Walker JK. GPCRs and Arrestins in Airways: Implications for Asthma. Handb Exp Pharmacol. 2014; 219:387-403. PMID: 24292841.
      Citations:    
    57. Deshpande DA, Yan H, Kong KC, Tiegs BC, Morgan SJ, Pera T, Panettieri RA, Eckhart AD, Penn RB. Exploiting functional domains of GRK2/3 to alter the competitive balance of pro- and anticontractile signaling in airway smooth muscle. FASEB J. 2014 Feb; 28(2):956-65. PMID: 24132623.
      Citations:    
    58. Horvat SJ, Deshpande DA, Yan H, Panettieri RA, Codina J, DuBose TD, Xin W, Rich TC, Penn RB. A-kinase anchoring proteins regulate compartmentalized cAMP signaling in airway smooth muscle. FASEB J. 2012 Sep; 26(9):3670-9. PMID: 22649031.
      Citations:    
    59. Billington CK, Ojo OO, Penn RB, Ito S. cAMP regulation of airway smooth muscle function. Pulm Pharmacol Ther. 2013 Feb; 26(1):112-20. PMID: 22634112.
      Citations:    
    60. Goncharova EA, Goncharov DA, Zhao H, Penn RB, Krymskaya VP, Panettieri RA. ß2-adrenergic receptor agonists modulate human airway smooth muscle cell migration via vasodilator-stimulated phosphoprotein. Am J Respir Cell Mol Biol. 2012 Jan; 46(1):48-54. PMID: 22210825.
      Citations:    
    61. Codina J, Opyd TS, Powell ZB, Furdui CM, Petrovic S, Penn RB, DuBose TD. pH-dependent regulation of the a-subunit of H+-K+-ATPase (HKa2). Am J Physiol Renal Physiol. 2011 Sep; 301(3):F536-43. PMID: 21653633.
      Citations:    
    62. Yan H, Deshpande DA, Misior AM, Miles MC, Saxena H, Riemer EC, Pascual RM, Panettieri RA, Penn RB. Anti-mitogenic effects of ß-agonists and PGE2 on airway smooth muscle are PKA dependent. FASEB J. 2011 Jan; 25(1):389-97. PMID: 20805374.
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    63. Sun X, Yang LV, Tiegs BC, Arend LJ, McGraw DW, Penn RB, Petrovic S. Deletion of the pH sensor GPR4 decreases renal acid excretion. J Am Soc Nephrol. 2010 Oct; 21(10):1745-55. PMID: 20798260.
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    64. Loza MJ, Foster S, Bleecker ER, Peters SP, Penn RB. Asthma and gender impact accumulation of T cell subtypes. Respir Res. 2010; 11:103. PMID: 20667106.
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    65. Loza MJ, Penn RB. Regulation of T cells in airway disease by beta-agonist. Front Biosci (Schol Ed). 2010; 2:969-79. PMID: 20515836.
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    66. Penn RB. Agonizing over agonism: should asthmatics turn their beta-receptors on or off? Proc Natl Acad Sci U S A. 2009 Feb 17; 106(7):2095-6. PMID: 19211783.
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    67. Misior AM, Deshpande DA, Loza MJ, Pascual RM, Hipp JD, Penn RB. Glucocorticoid- and protein kinase A-dependent transcriptome regulation in airway smooth muscle. Am J Respir Cell Mol Biol. 2009 Jul; 41(1):24-39. PMID: 19059887.
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    68. Kong KC, Gandhi U, Martin TJ, Anz CB, Yan H, Misior AM, Pascual RM, Deshpande DA, Penn RB. Endogenous Gs-coupled receptors in smooth muscle exhibit differential susceptibility to GRK2/3-mediated desensitization. Biochemistry. 2008 Sep 2; 47(35):9279-88. PMID: 18690720.
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    69. Hua X, Chason KD, Fredholm BB, Deshpande DA, Penn RB, Tilley SL. Adenosine induces airway hyperresponsiveness through activation of A3 receptors on mast cells. J Allergy Clin Immunol. 2008 Jul; 122(1):107-13, 113.e1-7. PMID: 18472152.
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    70. Deshpande DA, Theriot BS, Penn RB, Walker JK. Beta-arrestins specifically constrain beta2-adrenergic receptor signaling and function in airway smooth muscle. FASEB J. 2008 Jul; 22(7):2134-41. PMID: 18337459.
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    71. Penn RB. Embracing emerging paradigms of G protein-coupled receptor agonism and signaling to address airway smooth muscle pathobiology in asthma. Naunyn Schmiedebergs Arch Pharmacol. 2008 Aug; 378(2):149-69. PMID: 18278482.
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    72. Penn RB, Benovic JL. Regulation of heterotrimeric G protein signaling in airway smooth muscle. Proc Am Thorac Soc. 2008 Jan 1; 5(1):47-57. PMID: 18094084.
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    73. Loza MJ, Foster S, Peters SP, Penn RB. Interactive effects of steroids and beta-agonists on accumulation of type 2 T cells. J Allergy Clin Immunol. 2008 Mar; 121(3):750.e1-5.e3. PMID: 18155275.
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    74. Misior AM, Yan H, Pascual RM, Deshpande DA, Panettieri RA, Penn RB. Mitogenic effects of cytokines on smooth muscle are critically dependent on protein kinase A and are unmasked by steroids and cyclooxygenase inhibitors. Mol Pharmacol. 2008 Feb; 73(2):566-74. PMID: 17993511.
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    75. Komalavilas P, Penn RB, Flynn CR, Thresher J, Lopes LB, Furnish EJ, Guo M, Pallero MA, Murphy-Ullrich JE, Brophy CM. The small heat shock-related protein, HSP20, is a cAMP-dependent protein kinase substrate that is involved in airway smooth muscle relaxation. Am J Physiol Lung Cell Mol Physiol. 2008 Jan; 294(1):L69-78. PMID: 17993590.
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    76. Hua X, Erikson CJ, Chason KD, Rosebrock CN, Deshpande DA, Penn RB, Tilley SL. Involvement of A1 adenosine receptors and neural pathways in adenosine-induced bronchoconstriction in mice. Am J Physiol Lung Cell Mol Physiol. 2007 Jul; 293(1):L25-32. PMID: 17468137.
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    77. Deshpande DA, Pascual RM, Wang SW, Eckman DM, Riemer EC, Funk CD, Penn RB. PKC-dependent regulation of the receptor locus dominates functional consequences of cysteinyl leukotriene type 1 receptor activation. FASEB J. 2007 Aug; 21(10):2335-42. PMID: 17392478.
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    78. Sastry KS, Karpova Y, Prokopovich S, Smith AJ, Essau B, Gersappe A, Carson JP, Weber MJ, Register TC, Chen YQ, Penn RB, Kulik G. Epinephrine protects cancer cells from apoptosis via activation of cAMP-dependent protein kinase and BAD phosphorylation. J Biol Chem. 2007 May 11; 282(19):14094-100. PMID: 17353197.
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    79. Penn RB, Ortega VE, Bleecker ER. A Roadmap to functional genomics. Physiol Genomics. 2007 Jun 19; 30(1):82-8. PMID: 17327496.
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    80. Loza MJ, Peters SP, Foster S, Khan IU, Penn RB. beta-Agonist enhances type 2 T-cell survival and accumulation. J Allergy Clin Immunol. 2007 Jan; 119(1):235-44. PMID: 17208607.
      Citations:    
    81. Deshpande DA, Penn RB. Targeting G protein-coupled receptor signaling in asthma. Cell Signal. 2006 Dec; 18(12):2105-20. PMID: 16828259.
      Citations:    
    82. Codina J, Liu J, Bleyer AJ, Penn RB, DuBose TD. Phosphorylation of S955 at the protein kinase A consensus promotes maturation of the alpha subunit of the colonic H+,K+ -ATPase. J Am Soc Nephrol. 2006 Jul; 17(7):1833-40. PMID: 16738016.
      Citations:    
    83. Kong KC, Billington CK, Gandhi U, Panettieri RA, Penn RB. Cooperative mitogenic signaling by G protein-coupled receptors and growth factors is dependent on G(q/11). FASEB J. 2006 Jul; 20(9):1558-60. PMID: 16723377.
      Citations:    
    84. Pascual RM, Carr EM, Seeds MC, Guo M, Panettieri RA, Peters SP, Penn RB. Regulatory features of interleukin-1beta-mediated prostaglandin E2 synthesis in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2006 Mar; 290(3):L501-8. PMID: 16299051.
      Citations:    
    85. Huang CD, Ammit AJ, Tliba O, Kuo HP, Penn RB, Panettieri RA, Amrani Y. G-protein-coupled receptor agonists differentially regulate basal or tumor necrosis factor-alpha-stimulated activation of interleukin-6 and RANTES in human airway smooth muscle cells. J Biomed Sci. 2005 Oct; 12(5):763-76. PMID: 16228299.
      Citations:    
    86. Billington CK, Kong KC, Bhattacharyya R, Wedegaertner PB, Panettieri RA, Chan TO, Penn RB. Cooperative regulation of p70S6 kinase by receptor tyrosine kinases and G protein-coupled receptors augments airway smooth muscle growth. Biochemistry. 2005 Nov 8; 44(44):14595-605. PMID: 16262259.
      Citations:    
    87. Loza MJ, Foster S, Peters SP, Penn RB. Beta-agonists modulate T-cell functions via direct actions on type 1 and type 2 cells. Blood. 2006 Mar 1; 107(5):2052-60. PMID: 16278302.
      Citations:    
    88. Guo M, Pascual RM, Wang S, Fontana MF, Valancius CA, Panettieri RA, Tilley SL, Penn RB. Cytokines regulate beta-2-adrenergic receptor responsiveness in airway smooth muscle via multiple PKA- and EP2 receptor-dependent mechanisms. Biochemistry. 2005 Oct 25; 44(42):13771-82. PMID: 16229467.
      Citations:    
    89. Allen IC, Hartney JM, Coffman TM, Penn RB, Wess J, Koller BH. Thromboxane A2 induces airway constriction through an M3 muscarinic acetylcholine receptor-dependent mechanism. Am J Physiol Lung Cell Mol Physiol. 2006 Mar; 290(3):L526-33. PMID: 16243899.
      Citations:    
    90. Naik S, Billington CK, Pascual RM, Deshpande DA, Stefano FP, Kohout TA, Eckman DM, Benovic JL, Penn RB. Regulation of cysteinyl leukotriene type 1 receptor internalization and signaling. J Biol Chem. 2005 Mar 11; 280(10):8722-32. PMID: 15590629.
      Citations:    
    91. Iwata K, Luo J, Penn RB, Benovic JL. Bimodal regulation of the human H1 histamine receptor by G protein-coupled receptor kinase 2. J Biol Chem. 2005 Jan 21; 280(3):2197-204. PMID: 15542600.
      Citations:    
    92. Freyer AM, Billington CK, Penn RB, Hall IP. Extracellular matrix modulates beta2-adrenergic receptor signaling in human airway smooth muscle cells. Am J Respir Cell Mol Biol. 2004 Oct; 31(4):440-5. PMID: 15205178.
      Citations:    
    93. Billington CK, Penn RB. Signaling and regulation of G protein-coupled receptors in airway smooth muscle. Respir Res. 2003; 4:2. PMID: 12648290.
      Citations:    
    94. Pascual RM, Awsare BK, Farber SA, Panettieri RA, Peters SP, Penn RB. Regulation of phospholipase A2 by interleulin-1 in human airway smooth muscle. Chest. 2003 Mar; 123(3 Suppl):433S-4S. PMID: 12629024.
      Citations:    
    95. Goncharova EA, Billington CK, Irani C, Vorotnikov AV, Tkachuk VA, Penn RB, Krymskaya VP, Panettieri RA. Cyclic AMP-mobilizing agents and glucocorticoids modulate human smooth muscle cell migration. Am J Respir Cell Mol Biol. 2003 Jul; 29(1):19-27. PMID: 12600820.
      Citations:    
    96. Tilley SL, Hartney JM, Erikson CJ, Jania C, Nguyen M, Stock J, McNeisch J, Valancius C, Panettieri RA, Penn RB, Koller BH. Receptors and pathways mediating the effects of prostaglandin E2 on airway tone. Am J Physiol Lung Cell Mol Physiol. 2003 Apr; 284(4):L599-606. PMID: 12618422.
      Citations:    
    97. Ammit AJ, Lazaar AL, Irani C, O'Neill GM, Gordon ND, Amrani Y, Penn RB, Panettieri RA. Tumor necrosis factor-alpha-induced secretion of RANTES and interleukin-6 from human airway smooth muscle cells: modulation by glucocorticoids and beta-agonists. Am J Respir Cell Mol Biol. 2002 Apr; 26(4):465-74. PMID: 11919083.
      Citations:    
    98. Billington CK, Penn RB. m3 muscarinic acetylcholine receptor regulation in the airway. Am J Respir Cell Mol Biol. 2002 Mar; 26(3):269-72. PMID: 11867333.
      Citations:    
    99. Handley DA, Senanayake CH, Dutczak W, Benovic JL, Walle T, Penn RB, Wilkinson HS, Tanoury GJ, Andersson RG, Johansson F, Morley J. Biological actions of formoterol isomers. Pulm Pharmacol Ther. 2002; 15(2):135-45. PMID: 12090787.
      Citations:    
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