Raymond Regan

TitleProfessor
InstitutionThomas Jefferson University
DepartmentEmergency Medicine
Address1020 Sansom St.
Philadelphia PA 19107
Phone215-955-6844
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    R01NS042273     (REGAN, RAYMOND F)Jul 1, 2001 - May 31, 2012
    NIH
    Effect of Inducible Antioxidants on Hemoglobin Toxicity
    Role: Principal Investigator

    R01NS050662     (REGAN, RAYMOND F)Jan 1, 2006 - Dec 31, 2010
    NIH
    Optimizing Heme Oxygenase Activity after CNS Hemorrhage
    Role: Principal Investigator

    R21NS074289     (REGAN, RAYMOND F)Jul 1, 2011 - Dec 30, 2013
    NIH
    A fluorescent method to quantify neuronal injury after intracerebral hemorrhage
    Role: Principal Investigator

    R01NS079500     (REGAN, RAYMOND F)Jul 1, 2012 - May 31, 2017
    NIH
    Protective Effect of Hemin Preconditioning after Intracerebral Hemorrhage
    Role: Principal Investigator

    R21NS088986     (REGAN, RAYMOND F)Jul 15, 2015 - Jun 30, 2018
    NIH
    Effect of Hemopexin Therapy after Intracerebral Hemorrhage
    Role: Principal Investigator

    R01NS095205     (REGAN, RAYMOND F)May 1, 2016 - Apr 30, 2021
    NIH
    Protective effect of astrocyte heme oxygenase-1 after intracerebral hemorrhage
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chen-Roetling J, Li Y, Cao Y, Yan Z, Lu X, Regan RF. Effect of hemopexin treatment on outcome after intracerebral hemorrhage in mice. Brain Res. 2021 Apr 28; 1765:147507. PMID: 33930375.
      Citations:    
    2. Shaik NF, Regan RF, Naik UP. Platelets as drivers of ischemia/reperfusion injury after stroke. Blood Adv. 2021 Mar 09; 5(5):1576-1584. PMID: 33687431.
      Citations:    
    3. Verheijen N, Suttorp CM, van Rheden REM, Regan RF, Helmich MPAC, Kuijpers-Jagtman AM, Wagener FADTG. CXCL12-CXCR4 Interplay Facilitates Palatal Osteogenesis in Mice. Front Cell Dev Biol. 2020; 8:771. PMID: 32974338.
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    4. Peng D, Chen CA, Ruhela D, Li Y, Regan RF. Deferoxamine deconditioning increases neuronal vulnerability to hemoglobin. Exp Cell Res. 2020 May 01; 390(1):111926. PMID: 32112801.
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    5. Nath KA, Grande JP, Belcher JD, Garovic VD, Croatt AJ, Hillestad ML, Barry MA, Nath MC, Regan RF, Vercellotti GM. Antithrombotic Effects of Heme-Degrading and Heme-Binding Proteins. Am J Physiol Heart Circ Physiol. 2020 Jan 31. PMID: 32004074.
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    6. Chen-Roetling J, Cao Y, Peng D, Regan RF. Rapid Loss of Perihematomal Cell Viability in the Collagenase Intracerebral Hemorrhage Model. Brain Res. 2019 Jan 10. PMID: 30639124.
      Citations:    
    7. Chen-Roetling J, Regan KA, Regan RF. Protective effect of vitreous against hemoglobin neurotoxicity. Biochem Biophys Res Commun. 2018 Jun 06. PMID: 29859185.
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    8. Chen-Roetling J, Ma SK, Cao Y, Shah A, Regan RF. Hemopexin Increases the Neurotoxicity of Hemoglobin When Haptoglobin is Absent. J Neurochem. 2018 Mar 03. PMID: 29500821.
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    9. Suttorp CM, Cremers NA, van Rheden R, Regan RF, Helmich P, van Kempen S, Kuijpers-Jagtman AM, Wagener FADTG. Chemokine Signaling during Midline Epithelial Seam Disintegration Facilitates Palatal Fusion. Front Cell Dev Biol. 2017; 5:94. PMID: 29164113.
      Citations:    
    10. Chen-Roetling J, Kamalapathy P, Cao Y, Song W, Schipper HM, Regan RF. Astrocyte heme oxygenase-1 reduces mortality and improves outcome after collagenase-induced intracerebral hemorrhage. Neurobiol Dis. 2017 Jun; 102:140-146. PMID: 28323022.
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    11. Chen-Roetling J, Regan RF. Targeting the Nrf2-Heme Oxygenase-1 Axis after Intracerebral Hemorrhage. Curr Pharm Des. 2016 Oct 27. PMID: 27799046.
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    12. Chen-Roetling J, Regan RF. Haptoglobin increases the vulnerability of CD163-expressing neurons to hemoglobin. J Neurochem. 2016 Nov; 139(4):586-595. PMID: 27364920.
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    13. Elphinstone RE, Riley F, Lin T, Higgins S, Dhabangi A, Musoke C, Cserti-Gazdewich C, Regan RF, Warren HS, Kain KC. Dysregulation of the haem-haemopexin axis is associated with severe malaria in a case-control study of Ugandan children. Malar J. 2015; 14(1):511. PMID: 26691827.
      Citations:    
    14. Chen-Roetling J, Song W, Schipper HM, Regan CS, Regan RF. Astrocyte overexpression of heme oxygenase-1 improves outcome after intracerebral hemorrhage. Stroke. 2015 Apr; 46(4):1093-8. PMID: 25690543.
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    15. Rassu G, Soddu E, Cossu M, Brundu A, Cerri G, Marchetti N, Ferraro L, Regan RF, Giunchedi P, Gavini E, Dalpiaz A. Solid microparticles based on chitosan or methyl-ß-cyclodextrin: A first formulative approach to increase the nose-to-brain transport of deferoxamine mesylate. J Control Release. 2015 Mar 10; 201:68-77. PMID: 25620068.
      Citations:    
    16. Chen-Roetling J, Lu X, Regan RF. Targeting heme oxygenase after intracerebral hemorrhage. Ther Targets Neurol Dis. 2015 Jan 03; 2(1). PMID: 25642455.
      Citations:    
    17. Cremers NA, Lundvig DM, van Dalen SC, Schelbergen RF, van Lent PL, Szarek WA, Regan RF, Carels CE, Wagener FA. Curcumin-Induced Heme Oxygenase-1 Expression Prevents H2O2-Induced Cell Death in Wild Type and Heme Oxygenase-2 Knockout Adipose-Derived Mesenchymal Stem Cells. Int J Mol Sci. 2014; 15(10):17974-99. PMID: 25299695.
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    18. Lundvig DM, Scharstuhl A, Cremers NA, Pennings SW, Te Paske J, van Rheden R, van Run-van Breda C, Regan RF, Russel FG, Carels CE, Maltha JC, Wagener FA. Delayed cutaneous wound closure in HO-2 deficient mice despite normal HO-1 expression. J Cell Mol Med. 2014 Dec; 18(12):2488-98. PMID: 25224969.
      Citations:    
    19. Chen-Roetling J, Cai Y, Regan RF. Neuroprotective effect of heme oxygenase-2 knockout in the blood injection model of intracerebral hemorrhage. BMC Res Notes. 2014; 7(1):561. PMID: 25149897.
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    20. Lu X, Chen-Roetling J, Regan RF. Systemic hemin therapy attenuates blood-brain barrier disruption after intracerebral hemorrhage. Neurobiol Dis. 2014 Oct; 70:245-51. PMID: 24952361.
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    21. Chen-Roetling J, Lu X, Regan KA, Regan RF. A rapid fluorescent method to quantify neuronal loss after experimental intracerebral hemorrhage. J Neurosci Methods. 2013 Jun 15; 216(2):128-36. PMID: 23583700.
      Citations:    
    22. Chen-Roetling J, Sinanan J, Regan RF. Effect of iron chelators on methemoglobin and thrombin preconditioning. Transl Stroke Res. 2012 Dec; 3(4):452-9. PMID: 23585819.
      Citations:    
    23. Chen-Roetling J, Liu W, Regan RF. Hemopexin decreases hemin accumulation and catabolism by neural cells. Neurochem Int. 2012 Apr; 60(5):488-94. PMID: 22342655.
      Citations:    
    24. Chen-Roetling J, Liu W, Regan RF. Iron accumulation and neurotoxicity in cortical cultures treated with holotransferrin. Free Radic Biol Med. 2011 Dec 1; 51(11):1966-74. PMID: 21939754.
      Citations:    
    25. Chen L, Zhang X, Chen-Roetling J, Regan RF. Increased striatal injury and behavioral deficits after intracerebral hemorrhage in hemopexin knockout mice. J Neurosurg. 2011 Apr; 114(4):1159-67. PMID: 21128737.
      Citations:    
    26. Chen-Roetling J, Chen L, Regan RF. Apotransferrin protects cortical neurons from hemoglobin toxicity. Neuropharmacology. 2011 Feb-Mar; 60(2-3):423-31. PMID: 21034753.
      Citations:    
    27. Jaremko KM, Chen-Roetling J, Chen L, Regan RF. Accelerated hemolysis and neurotoxicity in neuron-glia-blood clot co-cultures. J Neurochem. 2010 Aug; 114(4):1063-73. PMID: 20497302.
      Citations:    
    28. Chen M, Awe OO, Chen-Roetling J, Regan RF. Iron regulatory protein-2 knockout increases perihematomal ferritin expression and cell viability after intracerebral hemorrhage. Brain Res. 2010 Jun 14; 1337:95-103. PMID: 20399759.
      Citations:    
    29. Bellner L, Martinelli L, Halilovic A, Patil K, Puri N, Dunn MW, Regan RF, Schwartzman ML. Heme oxygenase-2 deletion causes endothelial cell activation marked by oxidative stress, inflammation, and angiogenesis. J Pharmacol Exp Ther. 2009 Dec; 331(3):925-32. PMID: 19773531.
      Citations:    
    30. Chen-Roetling J, Chen L, Regan RF. Minocycline attenuates iron neurotoxicity in cortical cell cultures. Biochem Biophys Res Commun. 2009 Aug 21; 386(2):322-6. PMID: 19523448.
      Citations:    
    31. Li Z, Chen-Roetling J, Regan RF. Increasing expression of H- or L-ferritin protects cortical astrocytes from hemin toxicity. Free Radic Res. 2009 Jun; 43(6):613-21. PMID: 19513908.
      Citations:    
    32. Chen-Roetling J, Li Z, Chen M, Awe OO, Regan RF. Heme oxygenase activity and hemoglobin neurotoxicity are attenuated by inhibitors of the MEK/ERK pathway. Neuropharmacology. 2009 Apr; 56(5):922-8. PMID: 19371583.
      Citations:    
    33. Chen-Roetling J, Li Z, Regan RF. Hemoglobin neurotoxicity is attenuated by inhibitors of the protein kinase CK2 independent of heme oxygenase activity. Curr Neurovasc Res. 2008 Aug; 5(3):193-8. PMID: 18691077.
      Citations:    
    34. Regan RF, Li Z, Chen M, Zhang X, Chen-Roetling J. Iron regulatory proteins increase neuronal vulnerability to hydrogen peroxide. Biochem Biophys Res Commun. 2008 Oct 10; 375(1):6-10. PMID: 18655771.
      Citations:    
    35. Bellner L, Vitto M, Patil KA, Dunn MW, Regan R, Laniado-Schwartzman M. Exacerbated corneal inflammation and neovascularization in the HO-2 null mice is ameliorated by biliverdin. Exp Eye Res. 2008 Sep; 87(3):268-78. PMID: 18602389.
      Citations:    
    36. Regan RF, Chen M, Li Z, Zhang X, Benvenisti-Zarom L, Chen-Roetling J. Neurons lacking iron regulatory protein-2 are highly resistant to the toxicity of hemoglobin. Neurobiol Dis. 2008 Aug; 31(2):242-9. PMID: 18571425.
      Citations:    
    37. Chen M, Regan RF. Time course of increased heme oxygenase activity and expression after experimental intracerebral hemorrhage: correlation with oxidative injury. J Neurochem. 2007 Dec; 103(5):2015-21. PMID: 17760860.
      Citations:    
    38. Zabalgoitia M, Colston JT, Reddy SV, Holt JW, Regan RF, Stec DE, Rimoldi JM, Valente AJ, Chandrasekar B. Carbon monoxide donors or heme oxygenase-1 (HO-1) overexpression blocks interleukin-18-mediated NF-kappaB-PTEN-dependent human cardiac endothelial cell death. Free Radic Biol Med. 2008 Feb 1; 44(3):284-98. PMID: 18215737.
      Citations:    
    39. Benvenisti-Zarom L, Regan RF. Astrocyte-specific heme oxygenase-1 hyperexpression attenuates heme-mediated oxidative injury. Neurobiol Dis. 2007 Jun; 26(3):688-95. PMID: 17467999.
      Citations:    
    40. Qu Y, Chen-Roetling J, Benvenisti-Zarom L, Regan RF. Attenuation of oxidative injury after induction of experimental intracerebral hemorrhage in heme oxygenase-2 knockout mice. J Neurosurg. 2007 Mar; 106(3):428-35. PMID: 17367065.
      Citations:    
    41. de Godoy MA, Patel CA, Waldman SA, Katsuki M, Regan RF, Rattan S. H-ras inhibits RhoA/ROCK leading to a decrease in the basal tone in the internal anal sphincter. Gastroenterology. 2007 Apr; 132(4):1401-9. PMID: 17408635.
      Citations:    
    42. Seta F, Bellner L, Rezzani R, Regan RF, Dunn MW, Abraham NG, Gronert K, Laniado-Schwartzman M. Heme oxygenase-2 is a critical determinant for execution of an acute inflammatory and reparative response. Am J Pathol. 2006 Nov; 169(5):1612-23. PMID: 17071585.
      Citations:    
    43. Chen-Roetling J, Regan RF. Effect of heme oxygenase-1 on the vulnerability of astrocytes and neurons to hemoglobin. Biochem Biophys Res Commun. 2006 Nov 10; 350(1):233-7. PMID: 16999934.
      Citations:    
    44. Basuroy S, Bhattacharya S, Tcheranova D, Qu Y, Regan RF, Leffler CW, Parfenova H. HO-2 provides endogenous protection against oxidative stress and apoptosis caused by TNF-alpha in cerebral vascular endothelial cells. Am J Physiol Cell Physiol. 2006 Nov; 291(5):C897-908. PMID: 16822952.
      Citations:    
    45. Goodman AI, Chander PN, Rezzani R, Schwartzman ML, Regan RF, Rodella L, Turkseven S, Lianos EA, Dennery PA, Abraham NG. Heme oxygenase-2 deficiency contributes to diabetes-mediated increase in superoxide anion and renal dysfunction. J Am Soc Nephrol. 2006 Apr; 17(4):1073-81. PMID: 16524951.
      Citations:    
    46. Benvenisti-Zarom L, Chen-Roetling J, Regan RF. Inhibition of the ERK/MAP kinase pathway attenuates heme oxygenase-1 expression and heme-mediated neuronal injury. Neurosci Lett. 2006 May 8; 398(3):230-4. PMID: 16443326.
      Citations:    
    47. Parfenova H, Basuroy S, Bhattacharya S, Tcheranova D, Qu Y, Regan RF, Leffler CW. Glutamate induces oxidative stress and apoptosis in cerebral vascular endothelial cells: contributions of HO-1 and HO-2 to cytoprotection. Am J Physiol Cell Physiol. 2006 May; 290(5):C1399-410. PMID: 16371440.
      Citations:    
    48. Chen-Roetling J, Benvenisti-Zarom L, Regan RF. Cultured astrocytes from heme oxygenase-1 knockout mice are more vulnerable to heme-mediated oxidative injury. J Neurosci Res. 2005 Dec 15; 82(6):802-10. PMID: 16273550.
      Citations:    
    49. Rattan S, Regan RF, Patel CA, De Godoy MA. Nitric oxide not carbon monoxide mediates nonadrenergic noncholinergic relaxation in the murine internal anal sphincter. Gastroenterology. 2005 Dec; 129(6):1954-66. PMID: 16344064.
      Citations:    
    50. Qu Y, Chen J, Benvenisti-Zarom L, Ma X, Regan RF. Effect of targeted deletion of the heme oxygenase-2 gene on hemoglobin toxicity in the striatum. J Cereb Blood Flow Metab. 2005 Nov; 25(11):1466-75. PMID: 15902196.
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    51. Benvenisti-Zarom L, Chen J, Regan RF. The oxidative neurotoxicity of clioquinol. Neuropharmacology. 2005 Oct; 49(5):687-94. PMID: 15992834.
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    52. Chen J, Regan RF. Increasing expression of heme oxygenase-1 by proteasome inhibition protects astrocytes from heme-mediated oxidative injury. Curr Neurovasc Res. 2005 Jul; 2(3):189-96. PMID: 16181113.
      Citations:    
    53. Teng ZP, Chen J, Chau LY, Galunic N, Regan RF. Adenoviral transfer of the heme oxygenase-1 gene protects striatal astrocytes from heme-mediated oxidative injury. Neurobiol Dis. 2004 Nov; 17(2):179-87. PMID: 15474356.
      Citations:    
    54. Regan RF, Chen J, Benvenisti-Zarom L. Heme oxygenase-2 gene deletion attenuates oxidative stress in neurons exposed to extracellular hemin. BMC Neurosci. 2004 Sep 17; 5:34. PMID: 15377391.
      Citations:    
    55. Chen J, Regan RF. Heme oxygenase-2 gene deletion increases astrocyte vulnerability to hemin. Biochem Biophys Res Commun. 2004 May 21; 318(1):88-94. PMID: 15110757.
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    56. Vanderveldt GM, Regan RF. The neurotoxic effect of sickle cell hemoglobin. Free Radic Res. 2004 May; 38(5):431-7. PMID: 15293550.
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    57. Rogers B, Yakopson V, Teng ZP, Guo Y, Regan RF. Heme oxygenase-2 knockout neurons are less vulnerable to hemoglobin toxicity. Free Radic Biol Med. 2003 Oct 15; 35(8):872-81. PMID: 14556851.
      Citations:    
    58. Goldstein L, Teng ZP, Zeserson E, Patel M, Regan RF. Hemin induces an iron-dependent, oxidative injury to human neuron-like cells. J Neurosci Res. 2003 Jul 1; 73(1):113-21. PMID: 12815715.
      Citations:    
    59. Regan RF, Rogers B. Delayed treatment of hemoglobin neurotoxicity. J Neurotrauma. 2003 Jan; 20(1):111-20. PMID: 12614593.
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