Andres Klein-Szanto

Title	Volunteer Faculty
Institution	Thomas Jefferson University
Department	Faculty Records and Publicatio - Thomas Jefferson University
Address	833 Chestnut Street Philadelphia PA 19023
vCard	Download vCard

Research

research activities and funding

R01CA035552 (KLEIN-SZANTO, ANDRES J)Jul 1, 1983 - Dec 31, 1986 NIH CARCINOGENESIS OF XENOTRANSPLANTED HUMAN EPITHELIA Role: Principal Investigator

R01CA038863 (KLEIN-SZANTO, ANDRES J)Jan 1, 1985 - Dec 31, 1987 NIH MARKERS OF SKIN TUMOR PROGRESSION Role: Principal Investigator

R01CA044980 (KLEIN-SZANTO, ANDRES J)Apr 1, 1986 - Jan 31, 1994 NIH MARKERS OF SKIN TUMOR PROGRESSION Role: Principal Investigator

R01CA044981 (KLEIN-SZANTO, ANDRES J)Apr 1, 1986 - Mar 31, 1994 NIH CARCINOGENESIS OF XENOTRANSPLANTED HUMAN EPITHELIA Role: Principal Investigator

R01CA053713 (KLEIN-SZANTO, ANDRES J)Jan 1, 1991 - Dec 31, 1996 NIH TUMOR SUPPRESSOR GENES IN CHEMICALLY INDUCED SKIN TUMORS Role: Principal Investigator

R01CA071539 (KLEIN-SZANTO, ANDRES J)May 15, 1997 - Feb 28, 2003 NIH MOLECULAR CHANGES IN ORAL LESIONS OF CHEMICAL ETIOLOGY Role: Principal Investigator

R01CA075028 (KLEIN-SZANTO, ANDRES J)Jan 13, 1999 - Dec 31, 2007 NIH Progression of Chemical Induced Skin Tumors Role: Principal Investigator

R01CA107257 (KLEIN-SZANTO, ANDRES J)Aug 1, 2005 - Jul 31, 2009 NIH The Role of VILIP-1 in Development of Skin Tumors Role: Principal Investigator

S10RR024527 (KLEIN-SZANTO, ANDRES J)Apr 1, 2008 - Mar 31, 2009 NIH Tissue Arraying, Immunostaining, and Imaging System Role: Principal Investigator

R01CA133001 (KLEIN-SZANTO, ANDRES J)Apr 1, 2009 - Feb 28, 2014 NIH Furin and the Etiopathogenesis of UV-Induced Skin Cancer Role: Principal Investigator

Bibliographic

selected publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Strandberg J, Louie A, Lee S, Hahn M, Srinivasan P, George A, De La Cruz A, Zhang L, Hernandez Borrero L, Huntington KE, De La Cruz P, Seyhan AA, Koffer PP, Wazer DE, DiPetrillo TA, Graff SL, Azzoli CG, Rounds SI, Klein-Szanto AJ, Tavora F, Yakirevich E, Abbas AE, Zhou L, El-Deiry WS. TRAIL agonists rescue mice from radiation-induced lung, skin, or esophageal injury. J Clin Invest. 2025 Jan 14; 135(5). PMID: 39808500.

Citations:
Shin AE, Sugiura K, Kariuki SW, Cohen DA, Flashner SP, Klein-Szanto AJ, Nishiwaki N, De D, Vasan N, Gabre JT, Lengner CJ, Sims PA, Rustgi AK. LIN28B-mediated PI3K/AKT pathway activation promotes metastasis in colorectal cancer models. J Clin Invest. 2025 Apr 15; 135(8). PMID: 39808497.

Citations:
Su SH, Mitani Y, Li T, Sachdeva U, Flashner S, Klein-Szanto A, Dunbar KJ, Abrams J, Nakagawa H, Gabre J. Lactate Suppresses Growth of Esophageal Adenocarcinoma Patient-Derived Organoids through Alterations in Tumor NADH/NAD+ Redox State. Biomolecules. 2024 Sep 22; 14(9). PMID: 39334961.

Citations:
Shimonosono M, Morimoto M, Hirose W, Tomita Y, Matsuura N, Flashner S, Ebadi MS, Okayasu EH, Lee CY, Britton WR, Martin C, Wuertz BR, Parikh AS, Sachdeva UM, Ondrey FG, Atigadda VR, Elmets CA, Abrams JA, Muir AB, Klein-Szanto AJ, Weinberg KI, Momen-Heravi F, Nakagawa H. Modeling Epithelial Homeostasis and Perturbation in Three-Dimensional Human Esophageal Organoids. Biomolecules. 2024 Sep 05; 14(9). PMID: 39334892.

Citations:
Grando K, Bessho S, Harrell K, Kyrylchuk K, Pantoja AM, Olubajo S, Albicoro FJ, Klein-Szanto A, T?kel ?. Bacterial amyloid curli activates the host unfolded protein response via IRE1a in the presence of HLA-B27. Gut Microbes. 2024 Jan-Dec; 16(1):2392877. PMID: 39189642.

Citations:
Shimonosono M, Morimoto M, Hirose W, Tomita Y, Matsuura N, Flashner S, Ebadi MS, Okayasu EH, Lee CY, Britton WR, Martin C, Wuertz BR, Parikh AS, Sachdeva UM, Ondrey FG, Atigadda VR, Elmets CA, Abrams JA, Muir AB, Klein-Szanto AJ, Weinberg KI, Momen-Heravi F, Nakagawa H. Modeling epithelial homeostasis and perturbation in three-dimensional human esophageal organoids. bioRxiv. 2024 May 22. PMID: 38826379.

Citations:
Vendramini-Costa DB, Francescone R, Franco-Barraza J, Luong T, Graves M, de Aquino AM, Steele N, Gardiner JC, Dos Santos SAA, Ogier C, Malloy E, Borghaei L, Martinez E, Zhigarev DI, Tan Y, Lee H, Zhou Y, Cai KQ, Klein-Szanto AJ, Wang H, Andrake M, Dunbrack RL, Campbell K, Cukierman E. Netrin G1 Ligand is a new stromal immunomodulator that promotes pancreatic cancer. bioRxiv. 2024 May 18. PMID: 38798370.

Citations:
Kadariya Y, Sementino E, Ruan M, Cheung M, Hadikhani P, Osmanbeyoglu HU, Klein-Szanto AJ, Cai K, Testa JR. Low Exposures to Amphibole or Serpentine Asbestos in Germline Bap1-mutant Mice Induce Mesothelioma Characterized by an Immunosuppressive Tumor Microenvironment. Cancer Res Commun. 2024 04 08; 4(4):1004-1015. PMID: 38592450.

Citations:
Klochkova A, Karami AL, Fuller AD, Parham LR, Panchani SR, Natarajan S, Jackson JL, Mu A, Tan Y, Cai KQ, Klein-Szanto AJ, Muir AB, T?treault MP, Gra?a X, Hamilton KE, Whelan KA. Autophagy Contributes to Homeostasis in Esophageal Epithelium Where High Autophagic Vesicle Level Marks Basal Cells With Limited Proliferation and Enhanced Self-Renewal Potential. Cell Mol Gastroenterol Hepatol. 2024; 18(1):15-40. PMID: 38452871.

Citations:
Flashner S, Shimonosono M, Tomita Y, Matsuura N, Ohashi S, Muto M, Klein-Szanto AJ, Alan Diehl J, Chen CH, Mochly-Rosen D, Weinberg KI, Nakagawa H. ALDH2 dysfunction and alcohol cooperate in cancer stem cell enrichment. Carcinogenesis. 2024 02 12; 45(1-2):95-106. PMID: 37978873.

Citations:
Masuda MY, Pyon GC, Luo H, LeSuer WE, Putikova A, Dao A, Ortiz DR, Schulze AR, Fritz N, Kobayashi T, Iijima K, Klein-Szanto AJ, Shimonosono M, Flashner S, Morimoto M, Pai RK, Rank MA, Nakagawa H, Kita H, Wright BL, Doyle AD. Epithelial overexpression of IL-33 induces eosinophilic esophagitis dependent on IL-13. J Allergy Clin Immunol. 2024 May; 153(5):1355-1368. PMID: 38310974.

Citations:
Efe G, Dunbar KJ, Sugiura K, Cunningham K, Carcamo S, Karaiskos S, Tang Q, Cruz-Acu?a R, Resnick-Silverman L, Peura J, Lu C, Hasson D, Klein-Szanto AJ, Taylor AM, Manfredi JJ, Prives C, Rustgi AK. p53 Gain-of-Function Mutation Induces Metastasis via BRD4-Dependent CSF-1 Expression. Cancer Discov. 2023 12 12; 13(12):2632-2651. PMID: 37676642.

Citations:
Klochkova A, Karami AL, Fuller AD, Parham LR, Panchani SR, Natarajan S, Jackson JL, Mu A, Tan Y, Cai KQ, Klein-Szanto AJ, Muir AB, T?treault MP, Hamilton KE, Whelan KA. Autophagy contributes to homeostasis in esophageal epithelium where high autophagic vesicle content marks basal cells with limited proliferation and enhanced self-renewal potential. bioRxiv. 2023 Sep 22. PMID: 37781581.

Citations:
Dunbar KJ, Karakasheva TA, Tang Q, Efe G, Lin EW, Harris M, Sahu V, Sachdeva UM, Hu J, Klein-Szanto AJ, Henick B, Diehl JA, Nakagawa H, Rustgi AK. Tumor-Derived CCL5 Recruits Cancer-Associated Fibroblasts and Promotes Tumor Cell Proliferation in Esophageal Squamous Cell Carcinoma. Mol Cancer Res. 2023 07 05; 21(7):741-752. PMID: 37027010.

Citations:
Kabir MF, Jackson JL, Fuller AD, Gathuka L, Karami AL, Conde DG, Klochkova A, Mu A, Cai KQ, Klein-Szanto AJ, Muir AB, Whelan KA. Diclofenac exhibits cytotoxic activity associated with metabolic alterations and p53 induction in ESCC cell lines and decreases ESCC tumor burden in vivo. Carcinogenesis. 2023 05 26; 44(2):182-195. PMID: 37014121.

Citations:
Fuller AD, Karami AL, Kabir MF, Klochkova A, Jackson JL, Mu A, Tan Y, Klein-Szanto AJ, Whelan KA. Eosinophilic esophagitis-associated epithelial remodeling may limit esophageal carcinogenesis. Front Allergy. 2023; 4:1086032. PMID: 37064719.

Citations:
Bessho S, Grando KCM, Kyrylchuk K, Miller A, Klein-Szanto AJ, Zhu W, Gallucci S, Tam V, T?kel ?. Systemic exposure to bacterial amyloid curli alters the gut mucosal immune response and the microbiome, exacerbating Salmonella-induced arthritis. Gut Microbes. 2023 Jan-Dec; 15(1):2221813. PMID: 37317012.

Citations:
Fedele M, Battista S, Kenyon L, Baldassarre G, Fidanza V, Klein-Szanto AJP, Parlow AF, Visone R, Pierantoni GM, Outwater E, Santoro M, Croce CM, Fusco A. Correction to: Overexpression of the HMGA2 gene in transgenic mice leads to the onset of pituitary adenomas. Oncogene. 2023 Jan; 42(5):406. PMID: 36544045.

Citations:
Flashner S, Martin C, Matsuura N, Shimonosono M, Tomita Y, Morimoto M, Okolo O, Yu VX, Parikh AS, Klein-Szanto AJP, Yan K, Gabre JT, Lu C, Momen-Heravi F, Rustgi AK, Nakagawa H. Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids. J Vis Exp. 2022 12 23; (190). PMID: 36622034.

Citations:
Klochkova A, Fuller AD, Miller R, Karami AL, Panchani SR, Natarajan S, Mu A, Jackson JL, Klein-Szanto AJ, Muir AB, Whelan KA. A role for age-associated alterations in esophageal epithelium in eosinophilic esophagitis-associated fibrosis. Front Allergy. 2022; 3:983412. PMID: 36591561.

Citations:
Mucha B, Qie S, Bajpai S, Tarallo V, Diehl JN, Tedeschi F, Zhou G, Gao Z, Flashner S, Klein-Szanto AJ, Hibshoosh H, Masataka S, Chajewski OS, Majsterek I, Pytel D, Hatzoglou M, Der CJ, Nakagawa H, Bass AJ, Wong KK, Fuchs SY, Rustgi AK, Jankowsky E, Diehl JA. Tumor suppressor mediated ubiquitylation of hnRNPK is a barrier to oncogenic translation. Nat Commun. 2022 11 03; 13(1):6614. PMID: 36329064.

Citations:
Kumar S, Nandi A, Singh S, Regulapati R, Li N, Tobias JW, Siebel CW, Blanco MA, Klein-Szanto AJ, Lengner C, Welm AL, Kang Y, Chakrabarti R. Author Correction: Dll1+ quiescent tumor stem cells drive chemoresistance in breast cancer through NF-?B survival pathway. Nat Commun. 2022 Jul 07; 13(1):3927. PMID: 35798701.

Citations:
Shimonosono M, Tanaka K, Flashner S, Takada S, Matsuura N, Tomita Y, Sachdeva UM, Noguchi E, Sangwan V, Ferri L, Momen-Heravi F, Yoon AJ, Klein-Szanto AJ, Diehl JA, Nakagawa H. Alcohol Metabolism Enriches Squamous Cell Carcinoma Cancer Stem Cells That Survive Oxidative Stress via Autophagy. Biomolecules. 2021 10 07; 11(10). PMID: 34680112.

Citations:
Suzuki K, Masuike Y, Mizuno R, Sachdeva UM, Chatterji P, Andres SF, Sun W, Klein-Szanto AJ, Besharati S, Remotti HE, Verzi MP, Rustgi AK. LIN28B induces a differentiation program through CDX2 in colon cancer. JCI Insight. 2021 05 10; 6(9). PMID: 33755595.

Citations:
Tang Q, Efe G, Chiarella AM, Leung J, Chen M, Yamazoe T, Su Z, Pitarresi JR, Li J, Islam M, Karakasheva T, Klein-Szanto AJ, Pan S, Hu J, Natsugoe S, Gu W, Stanger BZ, Wong KK, Diehl JA, Bass AJ, Nakagawa H, Murphy ME, Rustgi AK. Mutant p53 regulates Survivin to foster lung metastasis. Genes Dev. 2021 04 01; 35(7-8):528-541. PMID: 33737385.

Citations:
Kumar S, Nandi A, Singh S, Regulapati R, Li N, Tobias JW, Siebel CW, Blanco MA, Klein-Szanto AJ, Lengner C, Welm AL, Kang Y, Chakrabarti R. Dll1+ quiescent tumor stem cells drive chemoresistance in breast cancer through NF-?B survival pathway. Nat Commun. 2021 01 18; 12(1):432. PMID: 33462238.

Citations:
Tang Q, Lento A, Suzuki K, Efe G, Karakasheva T, Long A, Giroux V, Islam M, Wileyto EP, Klein-Szanto AJ, Nakagawa H, Bass A, Rustgi AK. Rab11-FIP1 mediates epithelial-mesenchymal transition and invasion in esophageal cancer. EMBO Rep. 2021 02 03; 22(2):e48351. PMID: 33403789.

Citations:
Francescone R, Barbosa Vendramini-Costa D, Franco-Barraza J, Wagner J, Muir A, Lau AN, Gabitova L, Pazina T, Gupta S, Luong T, Rollins D, Malik R, Thapa RJ, Restifo D, Zhou Y, Cai KQ, Hensley HH, Tan Y, Kruger WD, Devarajan K, Balachandran S, Klein-Szanto AJ, Wang H, El-Deiry WS, Vander Heiden MG, Peri S, Campbell KS, Astsaturov I, Cukierman E. Netrin G1 Promotes Pancreatic Tumorigenesis through Cancer-Associated Fibroblast-Driven Nutritional Support and Immunosuppression. Cancer Discov. 2021 02; 11(2):446-479. PMID: 33127842.

Citations:
Chandramouleeswaran PM, Guha M, Shimonosono M, Whelan KA, Maekawa H, Sachdeva UM, Ruthel G, Mukherjee S, Engel N, Gonzalez MV, Garifallou J, Ohashi S, Klein-Szanto AJ, Mesaros CA, Blair IA, Pellegrino da Silva R, Hakonarson H, Noguchi E, Baur JA, Nakagawa H. Autophagy mitigates ethanol-induced mitochondrial dysfunction and oxidative stress in esophageal keratinocytes. PLoS One. 2020; 15(9):e0239625. PMID: 32966340.

Citations:
Karakasheva TA, Kijima T, Shimonosono M, Maekawa H, Sahu V, Gabre JT, Cruz-Acu?a R, Giroux V, Sangwan V, Whelan KA, Natsugoe S, Yoon AJ, Philipone E, Klein-Szanto AJ, Ginsberg GG, Falk GW, Abrams JA, Que J, Basu D, Ferri L, Diehl JA, Bass AJ, Wang TC, Rustgi AK, Nakagawa H. Generation and Characterization of Patient-Derived Head and Neck, Oral, and Esophageal Cancer Organoids. Curr Protoc Stem Cell Biol. 2020 06; 53(1):e109. PMID: 32294323.

Citations:
Weishaupt C, Mastrofrancesco A, Metze D, Kemper B, Stegemann A, Picardo M, Klein-Szanto AJP, B?hm M. Paired Basic Amino Acid-cleaving Enzyme 4 (PCSK6): An Emerging New Target Molecule in Human Melanoma. Acta Derm Venereol. 2020 May 28; 100(10):adv00157. PMID: 32449780.

Citations:
Guha M, Srinivasan S, Sheehan MM, Kijima T, Ruthel G, Whelan K, Tanaka K, Klein-Szanto A, Chandramouleeswaran PM, Nakagawa H, Avadhani NG. Esophageal 3D organoids of MPV17-/- mouse model of mitochondrial DNA depletion show epithelial cell plasticity and telomere attrition. Oncotarget. 2019 Oct 22; 10(58):6245-6259. PMID: 31692873.

Citations:
Whelan KA, Godwin BC, Wilkins B, Elci OU, Benitez A, DeMarshall M, Sharma M, Gross J, Klein-Szanto AJ, Liacouras CA, Dellon ES, Spergel JM, Falk GW, Muir AB, Nakagawa H. Persistent Basal Cell Hyperplasia Is Associated With Clinical and Endoscopic Findings in Patients With Histologically Inactive Eosinophilic Esophagitis. Clin Gastroenterol Hepatol. 2020 06; 18(7):1475-1482.e1. PMID: 31499251.

Citations:
Andres SF, Williams KN, Plesset JB, Headd JJ, Mizuno R, Chatterji P, Lento AA, Klein-Szanto AJ, Mick R, Hamilton KE, Rustgi AK. IMP1 3' UTR shortening enhances metastatic burden in colorectal cancer. Carcinogenesis. 2019 06 10; 40(4):569-579. PMID: 30407516.

Citations:
Kukuyan AM, Sementino E, Kadariya Y, Menges CW, Cheung M, Tan Y, Cai KQ, Slifker MJ, Peri S, Klein-Szanto AJ, Rauscher FJ, Testa JR. Inactivation of Bap1 Cooperates with Losses of Nf2 and Cdkn2a to Drive the Development of Pleural Malignant Mesothelioma in Conditional Mouse Models. Cancer Res. 2019 08 15; 79(16):4113-4123. PMID: 31151962.

Citations:
Guha M, Srinivasan S, Guja K, Mejia E, Garcia-Diaz M, Johnson FB, Ruthel G, Kaufman BA, Rappaport EF, Glineburg MR, Fang JK, Klein-Szanto AJ, Nakagawa H, Basha J, Kundu T, Avadhani NG. Correction to: HnRNPA2 is a novel histone acetyltransferase that mediates mitochondrial stress-induced nuclear gene expression. Cell Discov. 2019; 5:28. PMID: 31098295.

Citations:
Mercapide J, De Cicco RL, Bassi DE, Castresana JS, Thomas G, Klein-Szanto AJP. Correction: Inhibition of Furin-mediated Processing Results in Suppression of Astrocytoma Cell Growth and Invasiveness. Clin Cancer Res. 2019 Apr 15; 25(8):2674. PMID: 30988098.

Citations:
Klein-Szanto AJP, Bassi DE. Keep recycling going: New approaches to reduce LDL-C. Biochem Pharmacol. 2019 06; 164:336-341. PMID: 30953636.

Citations:
Kasagi Y, Dods K, Wang JX, Chandramouleeswaran PM, Benitez AJ, Gambanga F, Kluger J, Ashorobi T, Gross J, Tobias JW, Klein-Szanto AJ, Spergel JM, Cianferoni A, Falk GW, Whelan KA, Nakagawa H, Muir AB. Fibrostenotic eosinophilic esophagitis might reflect epithelial lysyl oxidase induction by fibroblast-derived TNF-a. J Allergy Clin Immunol. 2019 07; 144(1):171-182. PMID: 30578874.

Citations:
Fedele M, Fidanza V, Battista S, Pentimalli F, Klein-Szanto AJP, Visone R, De Martino I, Curcio A, Morisco C, Del Vecchio L, Baldassarre G, Arra C, Viglietto G, Indolfi C, Croce CM, Fusco A. Retraction: Haploinsufficiency of the Hmga1 Gene Causes Cardiac Hypertrophy and Myelo-Lymphoproliferative Disorders in Mice. Cancer Res. 2018 Dec 15; 78(24):6908. PMID: 30552126.

Citations:
Kijima T, Nakagawa H, Shimonosono M, Chandramouleeswaran PM, Hara T, Sahu V, Kasagi Y, Kikuchi O, Tanaka K, Giroux V, Muir AB, Whelan KA, Ohashi S, Naganuma S, Klein-Szanto AJ, Shinden Y, Sasaki K, Omoto I, Kita Y, Muto M, Bass AJ, Diehl JA, Ginsberg GG, Doki Y, Mori M, Uchikado Y, Arigami T, Avadhani NG, Basu D, Rustgi AK, Natsugoe S. Three-Dimensional Organoids Reveal Therapy Resistance of Esophageal and Oropharyngeal Squamous Cell Carcinoma Cells. Cell Mol Gastroenterol Hepatol. 2019; 7(1):73-91. PMID: 30510992.

Citations:
Chatterji P, Hamilton KE, Liang S, Andres SF, Wijeratne HRS, Mizuno R, Simon LA, Hicks PD, Foley SW, Pitarresi JR, Klein-Szanto AJ, Mah AT, Van Landeghem L, Gregory BD, Lengner CJ, Madison BB, Shah P, Rustgi AK. The LIN28B-IMP1 post-transcriptional regulon has opposing effects on oncogenic signaling in the intestine. Genes Dev. 2018 08 01; 32(15-16):1020-1034. PMID: 30068703.

Citations:
Karakasheva TA, Lin EW, Tang Q, Qiao E, Waldron TJ, Soni M, Klein-Szanto AJ, Sahu V, Basu D, Ohashi S, Baba K, Giaccone ZT, Walker SR, Frank DA, Wileyto EP, Long Q, Dunagin MC, Raj A, Diehl JA, Wong KK, Bass AJ, Rustgi AK. IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment. Cancer Res. 2018 09 01; 78(17):4957-4970. PMID: 29976575.

Citations:
Reichert M, Bakir B, Moreira L, Pitarresi JR, Feldmann K, Simon L, Suzuki K, Maddipati R, Rhim AD, Schlitter AM, Kriegsmann M, Weichert W, Wirth M, Schuck K, Schneider G, Saur D, Reynolds AB, Klein-Szanto AJ, Pehlivanoglu B, Memis B, Adsay NV, Rustgi AK. Regulation of Epithelial Plasticity Determines Metastatic Organotropism in Pancreatic Cancer. Dev Cell. 2018 06 18; 45(6):696-711.e8. PMID: 29920275.

Citations:
Sementino E, Menges CW, Kadariya Y, Peri S, Xu J, Liu Z, Wilkes RG, Cai KQ, Rauscher FJ, Klein-Szanto AJ, Testa JR. Inactivation of Tp53 and Pten drives rapid development of pleural and peritoneal malignant mesotheliomas. J Cell Physiol. 2018 11; 233(11):8952-8961. PMID: 29904909.

Citations:
Lewis-Wambi JS, Kim HR, Wambi C, Patel R, Pyle JR, Klein-Szanto AJ, Craig Jordan V. Correction to: Buthionine sulfoximine sensitizes antihormone-resistant human breast cancer cells to estrogen-induced apoptosis. Breast Cancer Res. 2018 06 14; 20(1):57. PMID: 29903038.

Citations:
Giroux V, Stephan J, Chatterji P, Rhoades B, Wileyto EP, Klein-Szanto AJ, Lengner CJ, Hamilton KE, Rustgi AK. Mouse Intestinal Krt15+ Crypt Cells Are Radio-Resistant and Tumor Initiating. Stem Cell Reports. 2018 06 05; 10(6):1947-1958. PMID: 29805107.

Citations:
Kasagi Y, Chandramouleeswaran PM, Whelan KA, Tanaka K, Giroux V, Sharma M, Wang J, Benitez AJ, DeMarshall M, Tobias JW, Hamilton KE, Falk GW, Spergel JM, Klein-Szanto AJ, Rustgi AK, Muir AB, Nakagawa H. The Esophageal Organoid System Reveals Functional Interplay Between Notch and Cytokines in Reactive Epithelial?Changes. Cell Mol Gastroenterol Hepatol. 2018 Mar; 5(3):333-352. PMID: 29552622.

Citations:
Natsuizaka M, Whelan KA, Kagawa S, Tanaka K, Giroux V, Chandramouleeswaran PM, Long A, Sahu V, Darling DS, Que J, Yang Y, Katz JP, Wileyto EP, Basu D, Kita Y, Natsugoe S, Naganuma S, Klein-Szanto AJ, Diehl JA, Bass AJ, Wong KK, Rustgi AK, Nakagawa H. Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma. Nat Commun. 2017 11 24; 8(1):1758. PMID: 29170450.

Citations:
Giroux V, Lento AA, Islam M, Pitarresi JR, Kharbanda A, Hamilton KE, Whelan KA, Long A, Rhoades B, Tang Q, Nakagawa H, Lengner CJ, Bass AJ, Wileyto EP, Klein-Szanto AJ, Wang TC, Rustgi AK. Long-lived keratin 15+ esophageal progenitor cells contribute to homeostasis and regeneration. J Clin Invest. 2017 Jun 01; 127(6):2378-2391. PMID: 28481227.

Citations:
Klein-Szanto AJ, Bassi DE. Proprotein convertase inhibition: Paralyzing the cell's master switches. Biochem Pharmacol. 2017 09 15; 140:8-15. PMID: 28456517.

Citations:
Whelan KA, Chandramouleeswaran PM, Tanaka K, Natsuizaka M, Guha M, Srinivasan S, Darling DS, Kita Y, Natsugoe S, Winkler JD, Klein-Szanto AJ, Amaravadi RK, Avadhani NG, Rustgi AK, Nakagawa H. Autophagy supports generation of cells with high CD44 expression via modulation of oxidative stress and Parkin-mediated mitochondrial clearance. Oncogene. 2017 08 24; 36(34):4843-4858. PMID: 28414310.

Citations:
Pero R, Palmieri D, Angrisano T, Valentino T, Federico A, Franco R, Lembo F, Klein-Szanto AJ, Del Vecchio L, Montanaro D, Keller S, Arra C, Papadopoulou V, Wagner SD, Croce CM, Fusco A, Chiariotti L, Fedele M. POZ-, AT-hook-, and zinc finger-containing protein (PATZ) interacts with the human oncogene B cell lymphoma 6 (BCL6) and is required for its negative autoregulation. J Biol Chem. 2017 03 31; 292(13):5609. PMID: 28363935.

Citations:
Tan Y, Sementino E, Xu J, Pei J, Liu Z, Ito TK, Cai KQ, Peri S, Klein-Szanto AJ, Wiest DL, Testa JR. The homeoprotein Dlx5 drives murine T-cell lymphomagenesis by directly transactivating Notch and upregulating Akt signaling. Oncotarget. 2017 Feb 28; 8(9):14941-14956. PMID: 28122332.

Citations:
Guha M, Srinivasan S, Guja K, Mejia E, Garcia-Diaz M, Johnson FB, Ruthel G, Kaufman BA, Rappaport EF, Glineburg MR, Fang JK, Klein-Szanto AJ, Klein Szanto A, Nakagawa H, Basha J, Kundu T, Avadhani NG. HnRNPA2 is a novel histone acetyltransferase that mediates mitochondrial stress-induced nuclear gene expression. Cell Discov. 2016; 2:16045. PMID: 27990297.

Citations:
Bassi DE, Zhang J, Renner C, Klein-Szanto AJ. Targeting proprotein convertases in furin-rich lung cancer cells results in decreased in vitro and in vivo growth. Mol Carcinog. 2017 03; 56(3):1182-1188. PMID: 27584082.

Citations:
Wang Y, Cai KQ, Smith ER, Yeasky TM, Moore R, Ganjei-Azar P, Klein-Szanto AJ, Godwin AK, Hamilton TC, Xu XX. Follicle Depletion Provides a Permissive Environment for Ovarian Carcinogenesis. Mol Cell Biol. 2016 09 15; 36(18):2418-30. PMID: 27354067.

Citations:
Tanaka K, Whelan KA, Chandramouleeswaran PM, Kagawa S, Rustgi SL, Noguchi C, Guha M, Srinivasan S, Amanuma Y, Ohashi S, Muto M, Klein-Szanto AJ, Noguchi E, Avadhani NG, Nakagawa H. ALDH2 modulates autophagy flux to regulate acetaldehyde-mediated toxicity thresholds. Am J Cancer Res. 2016; 6(4):781-96. PMID: 27186430.

Citations:
Kadariya Y, Menges CW, Talarchek J, Cai KQ, Klein-Szanto AJ, Pietrofesa RA, Christofidou-Solomidou M, Cheung M, Mossman BT, Shukla A, Testa JR. Inflammation-Related IL1?/IL1R Signaling Promotes the Development of Asbestos-Induced Malignant Mesothelioma. Cancer Prev Res (Phila). 2016 05; 9(5):406-414. PMID: 26935421.

Citations:
Kadariya Y, Cheung M, Xu J, Pei J, Sementino E, Menges CW, Cai KQ, Rauscher FJ, Klein-Szanto AJ, Testa JR. Bap1 Is a Bona Fide Tumor Suppressor: Genetic Evidence from Mouse Models Carrying Heterozygous Germline Bap1 Mutations. Cancer Res. 2016 05 01; 76(9):2836-44. PMID: 26896281.

Citations:
T?treault MP, Weinblatt D, Ciolino JD, Klein-Szanto AJ, Sackey BK, Twyman-Saint Victor C, Karakasheva T, Teal V, Katz JP. Esophageal Expression of Active I?B Kinase-? in Mice?Up-Regulates Tumor Necrosis Factor and Granulocyte-Macrophage Colony-Stimulating Factor, Promoting?Inflammation and Angiogenesis. Gastroenterology. 2016 06; 150(7):1609-1619.e11. PMID: 26896735.

Citations:
Whelan KA, Merves JF, Giroux V, Tanaka K, Guo A, Chandramouleeswaran PM, Benitez AJ, Dods K, Que J, Masterson JC, Fernando SD, Godwin BC, Klein-Szanto AJ, Chikwava K, Ruchelli ED, Hamilton KE, Muir AB, Wang ML, Furuta GT, Falk GW, Spergel JM, Nakagawa H. Autophagy mediates epithelial cytoprotection in eosinophilic oesophagitis. Gut. 2017 07; 66(7):1197-1207. PMID: 26884425.

Citations:
Tricarico R, Cortellino S, Riccio A, Jagmohan-Changur S, Van der Klift H, Wijnen J, Turner D, Ventura A, Rovella V, Percesepe A, Lucci-Cordisco E, Radice P, Bertario L, Pedroni M, Ponz de Leon M, Mancuso P, Devarajan K, Cai KQ, Klein-Szanto AJ, Neri G, M?ller P, Viel A, Genuardi M, Fodde R, Bellacosa A. Involvement of MBD4 inactivation in mismatch repair-deficient tumorigenesis. Oncotarget. 2015 Dec 15; 6(40):42892-904. PMID: 26503472.

Citations:
Oppong GO, Rapsinski GJ, Tursi SA, Biesecker SG, Klein-Szanto AJ, Goulian M, McCauley C, Healy C, Wilson RP, T?kel C. Biofilm-associated bacterial amyloids dampen inflammation in the gut: oral treatment with curli fibres reduces the severity of hapten-induced colitis in mice. NPJ Biofilms Microbiomes. 2015; 1. PMID: 26855788.

Citations:
Gabitova L, Restifo D, Gorin A, Manocha K, Handorf E, Yang DH, Cai KQ, Klein-Szanto AJ, Cunningham D, Kratz LE, Herman GE, Golemis EA, Astsaturov I. Endogenous Sterol Metabolites Regulate Growth of EGFR/KRAS-Dependent Tumors via LXR. Cell Rep. 2015 Sep 22; 12(11):1927-38. PMID: 26344763.

Citations:
Long A, Giroux V, Whelan KA, Hamilton KE, T?treault MP, Tanaka K, Lee JS, Klein-Szanto AJ, Nakagawa H, Rustgi AK. WNT10A promotes an invasive and self-renewing phenotype in esophageal squamous cell carcinoma. Carcinogenesis. 2015 May; 36(5):598-606. PMID: 25795715.

Citations:
Albury TM, Pandey V, Gitto SB, Dominguez L, Spinel LP, Talarchek J, Klein-Szanto AJ, Testa JR, Altomare DA. Constitutively active Akt1 cooperates with KRas(G12D) to accelerate in vivo pancreatic tumor onset and progression. Neoplasia. 2015 Feb; 17(2):175-82. PMID: 25748236.

Citations:
Li Y, Chitnis N, Nakagawa H, Kita Y, Natsugoe S, Yang Y, Li Z, Wasik M, Klein-Szanto AJ, Rustgi AK, Diehl JA. PRMT5 is required for lymphomagenesis triggered by multiple oncogenic drivers. Cancer Discov. 2015 Mar; 5(3):288-303. PMID: 25582697.

Citations:
Lian Z, Lee EK, Bass AJ, Wong KK, Klein-Szanto AJ, Rustgi AK, Diehl JA. FBXO4 loss facilitates carcinogen induced papilloma development in mice. Cancer Biol Ther. 2015; 16(5):750-5. PMID: 25801820.

Citations:
Nikonova AS, Plotnikova OV, Serzhanova V, Efimov A, Bogush I, Cai KQ, Hensley HH, Egleston BL, Klein-Szanto A, Seeger-Nukpezah T, Golemis EA. Nedd9 restrains renal cystogenesis in Pkd1-/- mice. Proc Natl Acad Sci U S A. 2014 Sep 02; 111(35):12859-64. PMID: 25139996.

Citations:
Kagawa S, Natsuizaka M, Whelan KA, Facompre N, Naganuma S, Ohashi S, Kinugasa H, Egloff AM, Basu D, Gimotty PA, Klein-Szanto AJ, Bass AJ, Wong KK, Diehl JA, Rustgi AK, Nakagawa H. Cellular senescence checkpoint function determines differential Notch1-dependent oncogenic and tumor-suppressor activities. Oncogene. 2015 Apr 30; 34(18):2347-59. PMID: 24931169.

Citations:
Bassi DE, Cenna J, Zhang J, Cukierman E, Klein-Szanto AJ. Enhanced aggressiveness of benzopyrene-induced squamous carcinomas in transgenic mice overexpressing the proprotein convertase PACE4 (PCSK6). Mol Carcinog. 2015 Oct; 54(10):1122-31. PMID: 24845697.

Citations:
Fu J, Zhang J, Gong Y, Testa CL, Klein-Szanto AJ. Regulation of HIF-1 alpha by the proprotein convertases furin and PC7 in human squamous carcinoma cells. Mol Carcinog. 2015 Sep; 54(9):698-706. PMID: 24436242.

Citations:
Natsuizaka M, Kinugasa H, Kagawa S, Whelan KA, Naganuma S, Subramanian H, Chang S, Nakagawa KJ, Rustgi NL, Kita Y, Natsugoe S, Basu D, Gimotty PA, Klein-Szanto AJ, Diehl JA, Nakagawa H. IGFBP3 promotes esophageal cancer growth by suppressing oxidative stress in hypoxic tumor microenvironment. Am J Cancer Res. 2014; 4(1):29-41. PMID: 24482736.

Citations:
Vega ME, Giroux V, Natsuizaka M, Liu M, Klein-Szanto AJ, Stairs DB, Nakagawa H, Wang KK, Wang TC, Lynch JP, Rustgi AK. Inhibition of Notch signaling enhances transdifferentiation of the esophageal squamous epithelium towards a Barrett's-like metaplasia via KLF4. Cell Cycle. 2014; 13(24):3857-66. PMID: 25558829.

Citations:
Menges CW, Kadariya Y, Altomare D, Talarchek J, Neumann-Domer E, Wu Y, Xiao GH, Shapiro IM, Kolev VN, Pachter JA, Klein-Szanto AJ, Testa JR. Tumor suppressor alterations cooperate to drive aggressive mesotheliomas with enriched cancer stem cells via a p53-miR-34a-c-Met axis. Cancer Res. 2014 Feb 15; 74(4):1261-1271. PMID: 24371224.

Citations:
Fang CY, Egleston BL, Ridge JA, Lango MN, Bovbjerg DH, Studts JL, Burtness BA, Einarson MB, Klein-Szanto AJ. Psychosocial functioning and vascular endothelial growth factor in patients with head and neck cancer. Head Neck. 2014 Aug; 36(8):1113-9. PMID: 23804308.

Citations:
Rasanen K, Sriswasdi S, Valiga A, Tang HY, Zhang G, Perego M, Somasundaram R, Li L, Speicher K, Klein-Szanto AJ, Basu D, Rustgi AK, Speicher DW, Herlyn M. Comparative secretome analysis of epithelial and mesenchymal subpopulations of head and neck squamous cell carcinoma identifies S100A4 as a potential therapeutic target. Mol Cell Proteomics. 2013 Dec; 12(12):3778-92. PMID: 24037664.

Citations:
Wong GS, Lee JS, Park YY, Klein-Szanto AJ, Waldron TJ, Cukierman E, Herlyn M, Gimotty P, Nakagawa H, Rustgi AK. Periostin cooperates with mutant p53 to mediate invasion through the induction of STAT1 signaling in the esophageal tumor microenvironment. Oncogenesis. 2013 Aug 05; 2:e59. PMID: 23917221.

Citations:
Fernandez SV, Robertson FM, Pei J, Aburto-Chumpitaz L, Mu Z, Chu K, Alpaugh RK, Huang Y, Cao Y, Ye Z, Cai KQ, Boley KM, Klein-Szanto AJ, Devarajan K, Addya S, Cristofanilli M. Inflammatory breast cancer (IBC): clues for targeted therapies. Breast Cancer Res Treat. 2013 Jul; 140(1):23-33. PMID: 23784380.

Citations:
Hamilton KE, Noubissi FK, Katti PS, Hahn CM, Davey SR, Lundsmith ET, Klein-Szanto AJ, Rhim AD, Spiegelman VS, Rustgi AK. IMP1 promotes tumor growth, dissemination and a tumor-initiating cell phenotype in colorectal cancer cell xenografts. Carcinogenesis. 2013 Nov; 34(11):2647-54. PMID: 23764754.

Citations:
Fu J, Bassi DE, Zhang J, Li T, Cai KQ, Testa CL, Nicolas E, Klein-Szanto AJ. Enhanced UV-induced skin carcinogenesis in transgenic mice overexpressing proprotein convertases. Neoplasia. 2013 Feb; 15(2):169-79. PMID: 23441131.

Citations:
Do TV, Xiao F, Bickel LE, Klein-Szanto AJ, Pathak HB, Hua X, Howe C, O'Brien SW, Maglaty M, Ecsedy JA, Litwin S, Golemis EA, Schilder RJ, Godwin AK, Connolly DC. Aurora kinase A mediates epithelial ovarian cancer cell migration and adhesion. Oncogene. 2014 Jan 30; 33(5):539-49. PMID: 23334327.

Citations:
Little JL, Serzhanova V, Izumchenko E, Egleston BL, Parise E, Klein-Szanto AJ, Loudon G, Shubina M, Seo S, Kurokawa M, Ochs MF, Golemis EA. A requirement for Nedd9 in luminal progenitor cells prior to mammary tumorigenesis in MMTV-HER2/ErbB2 mice. Oncogene. 2014 Jan 23; 33(4):411-20. PMID: 23318423.

Citations:
Rizzolio F, Caligiuri I, Lucchetti C, Fratamico R, Tomei V, Gallo G, Agelan A, Ferrari G, Toffoli G, Klein-Szanto AJ, Giordano A. Dissecting Pin1 and phospho-pRb regulation. J Cell Physiol. 2013 Jan; 228(1):73-7. PMID: 22553088.

Citations:
Shatalova EG, Klein-Szanto AJ, Devarajan K, Cukierman E, Clapper ML. Estrogen and cytochrome P450 1B1 contribute to both early- and late-stage head and neck carcinogenesis. Cancer Prev Res (Phila). 2011 Jan; 4(1):107-15. PMID: 21205741.

Citations:
Sukhanova A, Gorin A, Serebriiskii IG, Gabitova L, Zheng H, Restifo D, Egleston BL, Cunningham D, Bagnyukova T, Liu H, Nikonova A, Adams GP, Zhou Y, Yang DH, Mehra R, Burtness B, Cai KQ, Klein-Szanto A, Kratz LE, Kelley RI, Weiner LM, Herman GE, Golemis EA, Astsaturov I. Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation. Cancer Discov. 2013 Jan; 3(1):96-111. PMID: 23125191.

Citations:
Morris JF, Sul JY, Kim MS, Klein-Szanto AJ, Schochet T, Rustgi A, Eberwine JH. Elk-1 phosphorylated at threonine-417 is present in diverse cancers and correlates with differentiation grade of colonic adenocarcinoma. Hum Pathol. 2013 May; 44(5):766-76. PMID: 23114923.

Citations:
Wong GS, Habibollahi P, Heidari P, Lee JS, Klein-Szanto AJ, Waldron TJ, Gimotty P, Nakagawa H, Taylor PR, Wang TC, Mahmood U, Rustgi AK. Optical imaging of periostin enables early endoscopic detection and characterization of esophageal cancer in mice. Gastroenterology. 2013 Feb; 144(2):294-297. PMID: 23085486.

Citations:
Chow HY, Jubb AM, Koch JN, Jaffer ZM, Stepanova D, Campbell DA, Duron SG, O'Farrell M, Cai KQ, Klein-Szanto AJ, Gutkind JS, Hoeflich KP, Chernoff J. p21-Activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model. Cancer Res. 2012 Nov 15; 72(22):5966-75. PMID: 22983922.

Citations:
Naganuma S, Whelan KA, Natsuizaka M, Kagawa S, Kinugasa H, Chang S, Subramanian H, Rhoades B, Ohashi S, Itoh H, Herlyn M, Diehl JA, Gimotty PA, Klein-Szanto AJ, Nakagawa H. Notch receptor inhibition reveals the importance of cyclin D1 and Wnt signaling in invasive esophageal squamous cell carcinoma. Am J Cancer Res. 2012; 2(4):459-75. PMID: 22860235.

Citations:
Pero R, Palmieri D, Angrisano T, Valentino T, Federico A, Franco R, Lembo F, Klein-Szanto AJ, Del Vecchio L, Montanaro D, Keller S, Arra C, Papadopoulou V, Wagner SD, Croce CM, Fusco A, Chiariotti L, Fedele M. POZ-, AT-hook-, and zinc finger-containing protein (PATZ) interacts with human oncogene B cell lymphoma 6 (BCL6) and is required for its negative autoregulation. J Biol Chem. 2012 May 25; 287(22):18308-17. PMID: 22493480.

Citations:
Fu J, Bassi DE, Zhang J, Li T, Nicolas E, Klein-Szanto AJ. Transgenic overexpression of the proprotein convertase furin enhances skin tumor growth. Neoplasia. 2012 Apr; 14(4):271-82. PMID: 22577343.

Citations:
Sch?nrath K, Klein-Szanto AJ, Braunewell KH. The putative tumor suppressor VILIP-1 counteracts epidermal growth factor-induced epidermal-mesenchymal transition in squamous carcinoma cells. PLoS One. 2012; 7(3):e33116. PMID: 22479362.

Citations:
Natsuizaka M, Naganuma S, Kagawa S, Ohashi S, Ahmadi A, Subramanian H, Chang S, Nakagawa KJ, Ji X, Liebhaber SA, Klein-Szanto AJ, Nakagawa H. Hypoxia induces IGFBP3 in esophageal squamous cancer cells through HIF-1a-mediated mRNA transcription and continuous protein synthesis. FASEB J. 2012 Jun; 26(6):2620-30. PMID: 22415309.

Citations:
Rizzolio F, Lucchetti C, Caligiuri I, Marchesi I, Caputo M, Klein-Szanto AJ, Bagella L, Castronovo M, Giordano A. Retinoblastoma tumor-suppressor protein phosphorylation and inactivation depend on direct interaction with Pin1. Cell Death Differ. 2012 Jul; 19(7):1152-61. PMID: 22322860.

Citations:
Watts JA, Zhang C, Klein-Szanto AJ, Kormish JD, Fu J, Zhang MQ, Zaret KS. Study of FoxA pioneer factor at silent genes reveals Rfx-repressed enhancer at Cdx2 and a potential indicator of esophageal adenocarcinoma development. PLoS Genet. 2011 Sep; 7(9):e1002277. PMID: 21935353.

Citations:
Vaites LP, Lee EK, Lian Z, Barbash O, Roy D, Wasik M, Klein-Szanto AJ, Rustgi AK, Diehl JA. The Fbx4 tumor suppressor regulates cyclin D1 accumulation and prevents neoplastic transformation. Mol Cell Biol. 2011 Nov; 31(22):4513-23. PMID: 21911473.

Citations:
Ohashi S, Natsuizaka M, Naganuma S, Kagawa S, Kimura S, Itoh H, Kalman RA, Nakagawa M, Darling DS, Basu D, Gimotty PA, Klein-Szanto AJ, Diehl JA, Herlyn M, Nakagawa H. A NOTCH3-mediated squamous cell differentiation program limits expansion of EMT-competent cells that express the ZEB transcription factors. Cancer Res. 2011 Nov 01; 71(21):6836-47. PMID: 21890822.

Citations:
Goetz JG, Minguet S, Navarro-L?rida I, Lazcano JJ, Samaniego R, Calvo E, Tello M, Osteso-Ib??ez T, Pellinen T, Echarri A, Cerezo A, Klein-Szanto AJ, Garcia R, Keely PJ, S?nchez-Mateos P, Cukierman E, Del Pozo MA. Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis. Cell. 2011 Jul 08; 146(1):148-63. PMID: 21729786.

Citations:
Cortellino S, Xu J, Sannai M, Moore R, Caretti E, Cigliano A, Le Coz M, Devarajan K, Wessels A, Soprano D, Abramowitz LK, Bartolomei MS, Rambow F, Bassi MR, Bruno T, Fanciulli M, Renner C, Klein-Szanto AJ, Matsumoto Y, Kobi D, Davidson I, Alberti C, Larue L, Bellacosa A. Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair. Cell. 2011 Jul 08; 146(1):67-79. PMID: 21722948.

Citations:
Hopper-Borge EA, Churchill T, Paulose C, Nicolas E, Jacobs JD, Ngo O, Kuang Y, Grinberg A, Westphal H, Chen ZS, Klein-Szanto AJ, Belinsky MG, Kruh GD. Contribution of Abcc10 (Mrp7) to in vivo paclitaxel resistance as assessed in Abcc10(-/-) mice. Cancer Res. 2011 May 15; 71(10):3649-57. PMID: 21576088.

Citations:
Altomare DA, Menges CW, Xu J, Pei J, Zhang L, Tadevosyan A, Neumann-Domer E, Liu Z, Carbone M, Chudoba I, Klein-Szanto AJ, Testa JR. Losses of both products of the Cdkn2a/Arf locus contribute to asbestos-induced mesothelioma development and cooperate to accelerate tumorigenesis. PLoS One. 2011 Apr 19; 6(4):e18828. PMID: 21526190.

Citations:
Stairs DB, Bayne LJ, Rhoades B, Vega ME, Waldron TJ, Kalabis J, Klein-Szanto A, Lee JS, Katz JP, Diehl JA, Reynolds AB, Vonderheide RH, Rustgi AK. Deletion of p120-catenin results in a tumor microenvironment with inflammation and cancer that establishes it as a tumor suppressor gene. Cancer Cell. 2011 Apr 12; 19(4):470-83. PMID: 21481789.

Citations:
Rudnick SI, Lou J, Shaller CC, Tang Y, Klein-Szanto AJ, Weiner LM, Marks JD, Adams GP. Influence of affinity and antigen internalization on the uptake and penetration of Anti-HER2 antibodies in solid tumors. Cancer Res. 2011 Mar 15; 71(6):2250-9. PMID: 21406401.

Citations:
Frank AK, Leu JI, Zhou Y, Devarajan K, Nedelko T, Klein-Szanto A, Hollstein M, Murphy ME. The codon 72 polymorphism of p53 regulates interaction with NF-{kappa}B and transactivation of genes involved in immunity and inflammation. Mol Cell Biol. 2011 Mar; 31(6):1201-13. PMID: 21245379.

Citations:
Sosa MS, Lopez-Haber C, Yang C, Wang H, Lemmon MA, Busillo JM, Luo J, Benovic JL, Klein-Szanto A, Yagi H, Gutkind JS, Parsons RE, Kazanietz MG. Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer. Mol Cell. 2010 Dec 22; 40(6):877-92. PMID: 21172654.

Citations:
Sch?nrath K, Pan W, Klein-Szanto AJ, Braunewell KH. Involvement of VILIP-1 (visinin-like protein) and opposite roles of cyclic AMP and GMP signaling in in vitro cell migration of murine skin squamous cell carcinoma. Mol Carcinog. 2011 May; 50(5):319-33. PMID: 21480386.

Citations:
Tetreault MP, Wang ML, Yang Y, Travis J, Yu QC, Klein-Szanto AJ, Katz JP. Klf4 overexpression activates epithelial cytokines and inflammation-mediated esophageal squamous cell cancer in mice. Gastroenterology. 2010 Dec; 139(6):2124-2134.e9. PMID: 20816834.

Citations:
Makhlin I, Zhang J, Long CJ, Devarajan K, Zhou Y, Klein-Szanto AJ, Huang M, Chernoff J, Boorjian SA. The mTOR pathway affects proliferation and chemosensitivity of urothelial carcinoma cells and is upregulated in a subset of human bladder cancers. BJU Int. 2011 Jul; 108(2 Pt 2):E84-90. PMID: 21050361.

Citations:
Fedele M, Visone R, De Martino I, Palmieri D, Valentino T, Esposito F, Klein-Szanto A, Arra C, Ciarmiello A, Croce CM, Fusco A. Expression of a truncated Hmga1b gene induces gigantism, lipomatosis and B-cell lymphomas in mice. Eur J Cancer. 2011 Feb; 47(3):470-8. PMID: 21044834.

Citations:
Quinn BA, Xiao F, Bickel L, Martin L, Hua X, Klein-Szanto A, Connolly DC. Development of a syngeneic mouse model of epithelial ovarian cancer. J Ovarian Res. 2010 Oct 19; 3:24. PMID: 20958993.

Citations:
Singh MK, Izumchenko E, Klein-Szanto AJ, Egleston BL, Wolfson M, Golemis EA. Enhanced genetic instability and dasatinib sensitivity in mammary tumor cells lacking NEDD9. Cancer Res. 2010 Nov 01; 70(21):8907-16. PMID: 20940402.

Citations:
Ohashi S, Natsuizaka M, Yashiro-Ohtani Y, Kalman RA, Nakagawa M, Wu L, Klein-Szanto AJ, Herlyn M, Diehl JA, Katz JP, Pear WS, Seykora JT, Nakagawa H. NOTCH1 and NOTCH3 coordinate esophageal squamous differentiation through a CSL-dependent transcriptional network. Gastroenterology. 2010 Dec; 139(6):2113-23. PMID: 20801121.

Citations:
Balaburski GM, Dardes RC, Johnson M, Haddad B, Zhu F, Ross EA, Sengupta S, Klein-Szanto A, Liu H, Lee ES, Kim H, Jordan VC. Raloxifene-stimulated experimental breast cancer with the paradoxical actions of estrogen to promote or prevent tumor growth: a unifying concept in anti-hormone resistance. Int J Oncol. 2010 Aug; 37(2):387-98. PMID: 20596666.

Citations:
Mabuchi S, Kawase C, Altomare DA, Morishige K, Hayashi M, Sawada K, Ito K, Terai Y, Nishio Y, Klein-Szanto AJ, Burger RA, Ohmichi M, Testa JR, Kimura T. Vascular endothelial growth factor is a promising therapeutic target for the treatment of clear cell carcinoma of the ovary. Mol Cancer Ther. 2010 Aug; 9(8):2411-22. PMID: 20663925.

Citations:
Bassi DE, Zhang J, Cenna J, Litwin S, Cukierman E, Klein-Szanto AJ. Proprotein convertase inhibition results in decreased skin cell proliferation, tumorigenesis, and metastasis. Neoplasia. 2010 Jul; 12(7):516-26. PMID: 20651981.

Citations:
Grugan KD, Miller CG, Yao Y, Michaylira CZ, Ohashi S, Klein-Szanto AJ, Diehl JA, Herlyn M, Han M, Nakagawa H, Rustgi AK. Fibroblast-secreted hepatocyte growth factor plays a functional role in esophageal squamous cell carcinoma invasion. Proc Natl Acad Sci U S A. 2010 Jun 15; 107(24):11026-31. PMID: 20534479.

Citations:
Michaylira CZ, Wong GS, Miller CG, Gutierrez CM, Nakagawa H, Hammond R, Klein-Szanto AJ, Lee JS, Kim SB, Herlyn M, Diehl JA, Gimotty P, Rustgi AK. Periostin, a cell adhesion molecule, facilitates invasion in the tumor microenvironment and annotates a novel tumor-invasive signature in esophageal cancer. Cancer Res. 2010 Jul 01; 70(13):5281-92. PMID: 20516120.

Citations:
Natsuizaka M, Ohashi S, Wong GS, Ahmadi A, Kalman RA, Budo D, Klein-Szanto AJ, Herlyn M, Diehl JA, Nakagawa H. Insulin-like growth factor-binding protein-3 promotes transforming growth factor-{beta}1-mediated epithelial-to-mesenchymal transition and motility in transformed human esophageal cells. Carcinogenesis. 2010 Aug; 31(8):1344-53. PMID: 20513670.

Citations:
Ohashi S, Natsuizaka M, Wong GS, Michaylira CZ, Grugan KD, Stairs DB, Kalabis J, Vega ME, Kalman RA, Nakagawa M, Klein-Szanto AJ, Herlyn M, Diehl JA, Rustgi AK, Nakagawa H. Epidermal growth factor receptor and mutant p53 expand an esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcription factors. Cancer Res. 2010 May 15; 70(10):4174-84. PMID: 20424117.

Citations:
Fu J, Jin F, Zhang J, Fong K, Bassi DE, Lopez De Cicco R, Ramaraju D, Braunewell KH, Conti C, Benavides F, Klein-Szanto AJ. VILIP-1 expression in vivo results in decreased mouse skin keratinocyte proliferation and tumor development. PLoS One. 2010 Apr 15; 5(4):e10196. PMID: 20419170.

Citations:
Sauter ER, Klein-Szanto A, Macgibbon B, Ehya H. Nipple aspirate fluid and ductoscopy to detect breast cancer. Diagn Cytopathol. 2010 Apr; 38(4):244-51. PMID: 19795490.

Citations:
Tetreault MP, Yang Y, Travis J, Yu QC, Klein-Szanto A, Tobias JW, Katz JP. Esophageal squamous cell dysplasia and delayed differentiation with deletion of kr?ppel-like factor 4 in murine esophagus. Gastroenterology. 2010 Jul; 139(1):171-81.e9. PMID: 20347813.

Citations:
Haenssen KK, Caldwell SA, Shahriari KS, Jackson SR, Whelan KA, Klein-Szanto AJ, Reginato MJ. ErbB2 requires integrin alpha5 for anoikis resistance via Src regulation of receptor activity in human mammary epithelial cells. J Cell Sci. 2010 Apr 15; 123(Pt 8):1373-82. PMID: 20332114.

Citations:
Patel RR, Sengupta S, Kim HR, Klein-Szanto AJ, Pyle JR, Zhu F, Li T, Ross EA, Oseni S, Fargnoli J, Jordan VC. Experimental treatment of oestrogen receptor (ER) positive breast cancer with tamoxifen and brivanib alaninate, a VEGFR-2/FGFR-1 kinase inhibitor: a potential clinical application of angiogenesis inhibitors. Eur J Cancer. 2010 Jun; 46(9):1537-53. PMID: 20303261.

Citations:
von Holzen U, Chen T, Boquoi A, Richter JE, Falk GW, Klein-Szanto AJ, Cooper H, Litwin S, Weinberg DS, Enders GH. Evidence for DNA damage checkpoint activation in barrett esophagus. Transl Oncol. 2010 Feb; 3(1):33-42. PMID: 20165693.

Citations:
Altomare DA, Zhang L, Deng J, Di Cristofano A, Klein-Szanto AJ, Kumar R, Testa JR. GSK690693 delays tumor onset and progression in genetically defined mouse models expressing activated Akt. Clin Cancer Res. 2010 Jan 15; 16(2):486-96. PMID: 20075391.

Citations:
Lee JJ, Natsuizaka M, Ohashi S, Wong GS, Takaoka M, Michaylira CZ, Budo D, Tobias JW, Kanai M, Shirakawa Y, Naomoto Y, Klein-Szanto AJ, Haase VH, Nakagawa H. Hypoxia activates the cyclooxygenase-2-prostaglandin E synthase axis. Carcinogenesis. 2010 Mar; 31(3):427-34. PMID: 20042640.

Citations:
Gumireddy K, Li A, Gimotty PA, Klein-Szanto AJ, Showe LC, Katsaros D, Coukos G, Zhang L, Huang Q. KLF17 is a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Nat Cell Biol. 2009 Nov; 11(11):1297-304. PMID: 19801974.

Citations:
Izumchenko E, Singh MK, Plotnikova OV, Tikhmyanova N, Little JL, Serebriiskii IG, Seo S, Kurokawa M, Egleston BL, Klein-Szanto A, Pugacheva EN, Hardy RR, Wolfson M, Connolly DC, Golemis EA. NEDD9 promotes oncogenic signaling in mammary tumor development. Cancer Res. 2009 Sep 15; 69(18):7198-206. PMID: 19738060.

Citations:
Mabuchi S, Kawase C, Altomare DA, Morishige K, Sawada K, Hayashi M, Tsujimoto M, Yamoto M, Klein-Szanto AJ, Schilder RJ, Ohmichi M, Testa JR, Kimura T. mTOR is a promising therapeutic target both in cisplatin-sensitive and cisplatin-resistant clear cell carcinoma of the ovary. Clin Cancer Res. 2009 Sep 01; 15(17):5404-13. PMID: 19690197.

Citations:
Fu J, Zhang J, Jin F, Patchefsky J, Braunewell KH, Klein-Szanto AJ. Promoter regulation of the visinin-like subfamily of neuronal calcium sensor proteins by nuclear respiratory factor-1. J Biol Chem. 2009 Oct 02; 284(40):27577-86. PMID: 19674972.

Citations:
Cai KQ, Caslini C, Capo-chichi CD, Slater C, Smith ER, Wu H, Klein-Szanto AJ, Godwin AK, Xu XX. Loss of GATA4 and GATA6 expression specifies ovarian cancer histological subtypes and precedes neoplastic transformation of ovarian surface epithelia. PLoS One. 2009 Jul 31; 4(7):e6454. PMID: 19649254.

Citations:
Kadariya Y, Yin B, Tang B, Shinton SA, Quinlivan EP, Hua X, Klein-Szanto A, Al-Saleem TI, Bassing CH, Hardy RR, Kruger WD. Mice heterozygous for germ-line mutations in methylthioadenosine phosphorylase (MTAP) die prematurely of T-cell lymphoma. Cancer Res. 2009 Jul 15; 69(14):5961-9. PMID: 19567676.

Citations:
Cai KQ, Wu H, Klein-Szanto AJ, Xu XX. Acquisition of a second mutation of the Tp53 alleles immediately precedes epithelial morphological transformation in ovarian tumorigenicity. Gynecol Oncol. 2009 Jul; 114(1):18-25. PMID: 19375154.

Citations:
Seiwert TY, Jagadeeswaran R, Faoro L, Janamanchi V, Nallasura V, El Dinali M, Yala S, Kanteti R, Cohen EE, Lingen MW, Martin L, Krishnaswamy S, Klein-Szanto A, Christensen JG, Vokes EE, Salgia R. The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma. Cancer Res. 2009 Apr 01; 69(7):3021-31. PMID: 19318576.

Citations:
Hartman TR, Nicolas E, Klein-Szanto A, Al-Saleem T, Cash TP, Simon MC, Henske EP. The role of the Birt-Hogg-Dub? protein in mTOR activation and renal tumorigenesis. Oncogene. 2009 Apr 02; 28(13):1594-604. PMID: 19234517.

Citations:
Lewis-Wambi JS, Kim HR, Wambi C, Patel R, Pyle JR, Klein-Szanto AJ, Jordan VC. Buthionine sulfoximine sensitizes antihormone-resistant human breast cancer cells to estrogen-induced apoptosis. Breast Cancer Res. 2008; 10(6):R104. PMID: 19061505.

Citations:
Braunewell KH, Klein-Szanto AJ, Szanto AJ. Visinin-like proteins (VSNLs): interaction partners and emerging functions in signal transduction of a subfamily of neuronal Ca2+ -sensor proteins. Cell Tissue Res. 2009 Feb; 335(2):301-16. PMID: 18989702.

Citations:
Gupta S, K?hnisch J, Mustafa A, Lhotak S, Schlachterman A, Slifker MJ, Klein-Szanto A, High KA, Austin RC, Kruger WD. Mouse models of cystathionine beta-synthase deficiency reveal significant threshold effects of hyperhomocysteinemia. FASEB J. 2009 Mar; 23(3):883-93. PMID: 18987302.

Citations:
Stairs DB, Nakagawa H, Klein-Szanto A, Mitchell SD, Silberg DG, Tobias JW, Lynch JP, Rustgi AK. Cdx1 and c-Myc foster the initiation of transdifferentiation of the normal esophageal squamous epithelium toward Barrett's esophagus. PLoS One. 2008; 3(10):e3534. PMID: 18953412.

Citations:
Lioni M, Noma K, Snyder A, Klein-Szanto A, Diehl JA, Rustgi AK, Herlyn M, Smalley KS. Bortezomib induces apoptosis in esophageal squamous cell carcinoma cells through activation of the p38 mitogen-activated protein kinase pathway. Mol Cancer Ther. 2008 Sep; 7(9):2866-75. PMID: 18790767.

Citations:
Schilder RJ, Sill MW, Lee RB, Shaw TJ, Senterman MK, Klein-Szanto AJ, Miner Z, Vanderhyden BC. Phase II evaluation of imatinib mesylate in the treatment of recurrent or persistent epithelial ovarian or primary peritoneal carcinoma: a Gynecologic Oncology Group Study. J Clin Oncol. 2008 Jul 10; 26(20):3418-25. PMID: 18612157.

Citations:
Fu J, Fong K, Bellacosa A, Ross E, Apostolou S, Bassi DE, Jin F, Zhang J, Cairns P, Iba?ez de Caceres I, Braunewell KH, Klein-Szanto AJ. VILIP-1 downregulation in non-small cell lung carcinomas: mechanisms and prediction of survival. PLoS One. 2008 Feb 27; 3(2):e1698. PMID: 18301774.

Citations:
Huang Q, Gumireddy K, Schrier M, le Sage C, Nagel R, Nair S, Egan DA, Li A, Huang G, Klein-Szanto AJ, Gimotty PA, Katsaros D, Coukos G, Zhang L, Pur? E, Agami R. The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis. Nat Cell Biol. 2008 Feb; 10(2):202-10. PMID: 18193036.

Citations:
Finnberg N, Klein-Szanto AJ, El-Deiry WS. TRAIL-R deficiency in mice promotes susceptibility to chronic inflammation and tumorigenesis. J Clin Invest. 2008 Jan; 118(1):111-23. PMID: 18079962.

Citations:
Aggarwal P, Lessie MD, Lin DI, Pontano L, Gladden AB, Nuskey B, Goradia A, Wasik MA, Klein-Szanto AJ, Rustgi AK, Bassing CH, Diehl JA. Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication. Genes Dev. 2007 Nov 15; 21(22):2908-22. PMID: 18006686.

Citations:
Okawa T, Michaylira CZ, Kalabis J, Stairs DB, Nakagawa H, Andl CD, Johnstone CN, Klein-Szanto AJ, El-Deiry WS, Cukierman E, Herlyn M, Rustgi AK. The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation. Genes Dev. 2007 Nov 01; 21(21):2788-803. PMID: 17974918.

Citations:
Macias E, Kim Y, Miliani de Marval PL, Klein-Szanto A, Rodriguez-Puebla ML. Cdk2 deficiency decreases ras/CDK4-dependent malignant progression, but not myc-induced tumorigenesis. Cancer Res. 2007 Oct 15; 67(20):9713-20. PMID: 17942901.

Citations:
Xu RH, Fang M, Klein-Szanto A, Sigal LJ. Memory CD8+ T cells are gatekeepers of the lymph node draining the site of viral infection. Proc Natl Acad Sci U S A. 2007 Jun 26; 104(26):10992-7. PMID: 17578922.

Citations:
Garland LL, Rankin C, Gandara DR, Rivkin SE, Scott KM, Nagle RB, Klein-Szanto AJ, Testa JR, Altomare DA, Borden EC. Phase II study of erlotinib in patients with malignant pleural mesothelioma: a Southwest Oncology Group Study. J Clin Oncol. 2007 Jun 10; 25(17):2406-13. PMID: 17557954.

Citations:
Bassi DE, Klein-Szanto AJ. Carcinogen-induced animal models of head and neck squamous cell carcinoma. Curr Protoc Pharmacol. 2007 Jun; Chapter 14:Unit 14.2. PMID: 21948161.

Citations:
Gumireddy K, Sun F, Klein-Szanto AJ, Gibbins JM, Gimotty PA, Saunders AJ, Schultz PG, Huang Q. In vivo selection for metastasis promoting genes in the mouse. Proc Natl Acad Sci U S A. 2007 Apr 17; 104(16):6696-701. PMID: 17420453.

Citations:
Takaoka M, Kim SH, Okawa T, Michaylira CZ, Stairs DB, Johnstone CN, Andl CD, Rhoades B, Lee JJ, Klein-Szanto AJ, El-Deiry WS, Nakagawa H. IGFBP-3 regulates esophageal tumor growth through IGF-dependent and independent mechanisms. Cancer Biol Ther. 2007 Apr; 6(4):534-40. PMID: 17457048.

Citations:
Yang WL, Cai KQ, Smedberg JL, Smith ER, Klein-Szanto A, Hamilton TC, Xu XX. A reduction of cyclooxygenase 2 gene dosage counters the ovarian morphological aging and tumor phenotype in Wv mice. Am J Pathol. 2007 Apr; 170(4):1325-36. PMID: 17392171.

Citations:
Wang Y, Ylera F, Boston M, Kang SG, Kutok JL, Klein-Szanto AJ, Junghans RP. Focused antibody response in plasma cell-infiltrated non-medullary (NOS) breast cancers. Breast Cancer Res Treat. 2007 Aug; 104(2):129-44. PMID: 17393302.

Citations:
Henry LR, Lee HO, Lee JS, Klein-Szanto A, Watts P, Ross EA, Chen WT, Cheng JD. Clinical implications of fibroblast activation protein in patients with colon cancer. Clin Cancer Res. 2007 Mar 15; 13(6):1736-41. PMID: 17363526.

Citations:
Mabuchi S, Altomare DA, Connolly DC, Klein-Szanto A, Litwin S, Hoelzle MK, Hensley HH, Hamilton TC, Testa JR. RAD001 (Everolimus) delays tumor onset and progression in a transgenic mouse model of ovarian cancer. Cancer Res. 2007 Mar 15; 67(6):2408-13. PMID: 17363557.

Citations:
Sauter ER, Wagner-Mann C, Ehya H, Klein-Szanto A. Biologic markers of breast cancer in nipple aspirate fluid and nipple discharge are associated with clinical findings. Cancer Detect Prev. 2007; 31(1):50-8. PMID: 17317033.

Citations:
Yeager N, Klein-Szanto A, Kimura S, Di Cristofano A. Pten loss in the mouse thyroid causes goiter and follicular adenomas: insights into thyroid function and Cowden disease pathogenesis. Cancer Res. 2007 Feb 01; 67(3):959-66. PMID: 17283127.

Citations:
Belinsky MG, Guo P, Lee K, Zhou F, Kotova E, Grinberg A, Westphal H, Shchaveleva I, Klein-Szanto A, Gallo JM, Kruh GD. Multidrug resistance protein 4 protects bone marrow, thymus, spleen, and intestine from nucleotide analogue-induced damage. Cancer Res. 2007 Jan 01; 67(1):262-8. PMID: 17210706.

Citations:
Robb VA, Karbowniczek M, Klein-Szanto AJ, Henske EP. Activation of the mTOR signaling pathway in renal clear cell carcinoma. J Urol. 2007 Jan; 177(1):346-52. PMID: 17162089.

Citations:
Klein WM, Wu BP, Zhao S, Wu H, Klein-Szanto AJ, Tahan SR. Increased expression of stem cell markers in malignant melanoma. Mod Pathol. 2007 Jan; 20(1):102-7. PMID: 17143262.

Citations:
Yu Y, Fan J, Hui Y, Rouzer CA, Marnett LJ, Klein-Szanto AJ, FitzGerald GA, Funk CD. Targeted cyclooxygenase gene (ptgs) exchange reveals discriminant isoform functionality. J Biol Chem. 2007 Jan 12; 282(2):1498-506. PMID: 17110378.

Citations:
Lin DI, Barbash O, Kumar KG, Weber JD, Harper JW, Klein-Szanto AJ, Rustgi A, Fuchs SY, Diehl JA. Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex. Mol Cell. 2006 Nov 03; 24(3):355-66. PMID: 17081987.

Citations:
Kim SH, Nakagawa H, Navaraj A, Naomoto Y, Klein-Szanto AJ, Rustgi AK, El-Deiry WS. Tumorigenic conversion of primary human esophageal epithelial cells using oncogene combinations in the absence of exogenous Ras. Cancer Res. 2006 Nov 01; 66(21):10415-24. PMID: 17079462.

Citations:
Andl CD, Fargnoli BB, Okawa T, Bowser M, Takaoka M, Nakagawa H, Klein-Szanto A, Hua X, Herlyn M, Rustgi AK. Coordinated functions of E-cadherin and transforming growth factor beta receptor II in vitro and in vivo. Cancer Res. 2006 Oct 15; 66(20):9878-85. PMID: 17047049.

Citations:
Oyama K, Okawa T, Nakagawa H, Takaoka M, Andl CD, Kim SH, Klein-Szanto A, Diehl JA, Herlyn M, El-Deiry W, Rustgi AK. AKT induces senescence in primary esophageal epithelial cells but is permissive for differentiation as revealed in organotypic culture. Oncogene. 2007 Apr 05; 26(16):2353-64. PMID: 17043653.

Citations:
Wickborn C, Klein-Szanto AJ, Schlag PM, Braunewell KH. Correlation of visinin-like-protein-1 expression with clinicopathological features in squamous cell carcinoma of the esophagus. Mol Carcinog. 2006 Aug; 45(8):572-81. PMID: 16683251.

Citations:
Jones-Bolin S, Zhao H, Hunter K, Klein-Szanto A, Ruggeri B. The effects of the oral, pan-VEGF-R kinase inhibitor CEP-7055 and chemotherapy in orthotopic models of glioblastoma and colon carcinoma in mice. Mol Cancer Ther. 2006 Jul; 5(7):1744-53. PMID: 16891460.

Citations:
Yang DH, Fazili Z, Smith ER, Cai KQ, Klein-Szanto A, Cohen C, Horowitz IR, Xu XX. Disabled-2 heterozygous mice are predisposed to endometrial and ovarian tumorigenesis and exhibit sex-biased embryonic lethality in a p53-null background. Am J Pathol. 2006 Jul; 169(1):258-67. PMID: 16816378.

Citations:
Yu Y, Fan J, Chen XS, Wang D, Klein-Szanto AJ, Campbell RL, FitzGerald GA, Funk CD. Genetic model of selective COX2 inhibition reveals novel heterodimer signaling. Nat Med. 2006 Jun; 12(6):699-704. PMID: 16732282.

Citations:
Cai KQ, Klein-Szanto A, Karthik D, Edelson M, Daly MB, Ozols RF, Lynch HT, Godwin AK, Xu XX. Age-dependent morphological alterations of human ovaries from populations with and without BRCA mutations. Gynecol Oncol. 2006 Nov; 103(2):719-28. PMID: 16698071.

Citations:
Chen Y, Weeks RS, Burns MR, Boorman DW, Klein-Szanto A, O'Brien TG. Combination therapy with 2-difluoromethylornithine and a polyamine transport inhibitor against murine squamous cell carcinoma. Int J Cancer. 2006 May 01; 118(9):2344-9. PMID: 16331620.

Citations:
Vilgelm A, Lian Z, Wang H, Beauparlant SL, Klein-Szanto A, Ellenson LH, Di Cristofano A. Akt-mediated phosphorylation and activation of estrogen receptor alpha is required for endometrial neoplastic transformation in Pten+/- mice. Cancer Res. 2006 Apr 01; 66(7):3375-80. PMID: 16585156.

Citations:
Fedele M, Fidanza V, Battista S, Pentimalli F, Klein-Szanto AJ, Visone R, De Martino I, Curcio A, Morisco C, Del Vecchio L, Baldassarre G, Arra C, Viglietto G, Indolfi C, Croce CM, Fusco A. Haploinsufficiency of the Hmga1 gene causes cardiac hypertrophy and myelo-lymphoproliferative disorders in mice. Cancer Res. 2006 Mar 01; 66(5):2536-43. PMID: 16510570.

Citations:
Bassi DE, Fu J, Lopez de Cicco R, Klein-Szanto AJ. Proprotein convertases: "master switches" in the regulation of tumor growth and progression. Mol Carcinog. 2005 Nov; 44(3):151-61. PMID: 16167351.

Citations:
Khatib AM, Bassi D, Siegfried G, Klein-Szanto AJ, Ouafik L. Endo/exo-proteolysis in neoplastic progression and metastasis. J Mol Med (Berl). 2005 Nov; 83(11):856-64. PMID: 16133424.

Citations:
Bassi DE, Lopez De Cicco R, Cenna J, Litwin S, Cukierman E, Klein-Szanto AJ. PACE4 expression in mouse basal keratinocytes results in basement membrane disruption and acceleration of tumor progression. Cancer Res. 2005 Aug 15; 65(16):7310-9. PMID: 16103082.

Citations:
Johnson JE, Varkonyi RJ, Schwalm J, Cragle R, Klein-Szanto A, Patchefsky A, Cukierman E, von Mehren M, Broccoli D. Multiple mechanisms of telomere maintenance exist in liposarcomas. Clin Cancer Res. 2005 Aug 01; 11(15):5347-55. PMID: 16061847.

Citations:
Nunez MI, Rosen DG, Ludes-Meyers JH, Abba MC, Kil H, Page R, Klein-Szanto AJ, Godwin AK, Liu J, Mills GB, Aldaz CM. WWOX protein expression varies among ovarian carcinoma histotypes and correlates with less favorable outcome. BMC Cancer. 2005 Jun 27; 5:64. PMID: 15982416.

Citations:
Wang L, Chen X, Tang B, Hua X, Klein-Szanto A, Kruger WD. Expression of mutant human cystathionine beta-synthase rescues neonatal lethality but not homocystinuria in a mouse model. Hum Mol Genet. 2005 Aug 01; 14(15):2201-8. PMID: 15972722.

Citations:
Fedele M, Pentimalli F, Baldassarre G, Battista S, Klein-Szanto AJ, Kenyon L, Visone R, De Martino I, Ciarmiello A, Arra C, Viglietto G, Croce CM, Fusco A. Transgenic mice overexpressing the wild-type form of the HMGA1 gene develop mixed growth hormone/prolactin cell pituitary adenomas and natural killer cell lymphomas. Oncogene. 2005 May 12; 24(21):3427-35. PMID: 15735694.

Citations:
Guo S, Hakimi MA, Baillat D, Chen X, Farber MJ, Klein-Szanto AJ, Cooch NS, Godwin AK, Shiekhattar R. Linking transcriptional elongation and messenger RNA export to metastatic breast cancers. Cancer Res. 2005 Apr 15; 65(8):3011-6. PMID: 15833825.

Citations:
Belinsky MG, Dawson PA, Shchaveleva I, Bain LJ, Wang R, Ling V, Chen ZS, Grinberg A, Westphal H, Klein-Szanto A, Lerro A, Kruh GD. Analysis of the in vivo functions of Mrp3. Mol Pharmacol. 2005 Jul; 68(1):160-8. PMID: 15814571.

Citations:
Gonzalez Guerrico AM, Jaffer ZM, Page RE, Braunewell KH, Chernoff J, Klein-Szanto AJ. Visinin-like protein-1 is a potent inhibitor of cell adhesion and migration in squamous carcinoma cells. Oncogene. 2005 Mar 31; 24(14):2307-16. PMID: 15735716.

Citations:
Yu Y, Cheng Y, Fan J, Chen XS, Klein-Szanto A, Fitzgerald GA, Funk CD. Differential impact of prostaglandin H synthase 1 knockdown on platelets and parturition. J Clin Invest. 2005 Apr; 115(4):986-95. PMID: 15776109.

Citations:
Sauter ER, Ehya H, Klein-Szanto AJ, Wagner-Mann C, MacGibbon B. Fiberoptic ductoscopy findings in women with and without spontaneous nipple discharge. Cancer. 2005 Mar 01; 103(5):914-21. PMID: 15666326.

Citations:
Wu H, Barusevicius A, Babb J, Klein-Szanto A, Godwin A, Elenitsas R, Gelfand JM, Lessin S, Seykora JT. Pleiotrophin expression correlates with melanocytic tumor progression and metastatic potential. J Cutan Pathol. 2005 Feb; 32(2):125-30. PMID: 15606670.

Citations:
Stewart SL, Querec TD, Ochman AR, Gruver BN, Bao R, Babb JS, Wong TS, Koutroukides T, Pinnola AD, Klein-Szanto A, Hamilton TC, Patriotis C. Characterization of a carcinogenesis rat model of ovarian preneoplasia and neoplasia. Cancer Res. 2004 Nov 15; 64(22):8177-83. PMID: 15548682.

Citations:
Purev E, Cai D, Miller E, Swoboda R, Mayer T, Klein-Szanto A, Marincola FM, Mick R, Otvos L, Wunner W, Birebent B, Somasundaram R, Wikstrand CJ, Bigner D, DeMichele A, Acs G, Berlin JA, Herlyn D. Immune responses of breast cancer patients to mutated epidermal growth factor receptor (EGF-RvIII, Delta EGF-R, and de2-7 EGF-R). J Immunol. 2004 Nov 15; 173(10):6472-80. PMID: 15528389.

Citations:
Takaoka M, Harada H, Andl CD, Oyama K, Naomoto Y, Dempsey KL, Klein-Szanto AJ, El-Deiry WS, Grimberg A, Nakagawa H. Epidermal growth factor receptor regulates aberrant expression of insulin-like growth factor-binding protein 3. Cancer Res. 2004 Nov 01; 64(21):7711-23. PMID: 15520175.

Citations:
Sauter ER, Klein-Szanto A, Ehya H, MacGibbon B. Ductoscopic cytology and image analysis to detect breast carcinoma. Cancer. 2004 Sep 15; 101(6):1283-92. PMID: 15316899.

Citations:
Adams GP, Shaller CC, Dadachova E, Simmons HH, Horak EM, Tesfaye A, Klein-Szanto AJ, Marks JD, Brechbiel MW, Weiner LM. A single treatment of yttrium-90-labeled CHX-A"-C6.5 diabody inhibits the growth of established human tumor xenografts in immunodeficient mice. Cancer Res. 2004 Sep 01; 64(17):6200-6. PMID: 15342405.

Citations:
Altomare DA, Wang HQ, Skele KL, De Rienzo A, Klein-Szanto AJ, Godwin AK, Testa JR. AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth. Oncogene. 2004 Jul 29; 23(34):5853-7. PMID: 15208673.

Citations:
Balsara BR, Pei J, Mitsuuchi Y, Page R, Klein-Szanto A, Wang H, Unger M, Testa JR. Frequent activation of AKT in non-small cell lung carcinomas and preneoplastic bronchial lesions. Carcinogenesis. 2004 Nov; 25(11):2053-9. PMID: 15240509.

Citations:
Chen Y, Hu J, Boorman D, Klein-Szanto A, O'Brien TG. Therapy of murine squamous cell carcinomas with 2-difluoromethylornithine. J Carcinog. 2004 Jun 02; 3(1):10. PMID: 15175104.

Citations:
Krassenstein R, Sauter E, Dulaimi E, Battagli C, Ehya H, Klein-Szanto A, Cairns P. Detection of breast cancer in nipple aspirate fluid by CpG island hypermethylation. Clin Cancer Res. 2004 Jan 01; 10(1 Pt 1):28-32. PMID: 14734448.

Citations:
Mercapide J, Lopez De Cicco R, Castresana JS, Klein-Szanto AJ. Stromelysin-1/matrix metalloproteinase-3 (MMP-3) expression accounts for invasive properties of human astrocytoma cell lines. Int J Cancer. 2003 Sep 20; 106(5):676-82. PMID: 12866026.

Citations:
Ruggeri B, Singh J, Gingrich D, Angeles T, Albom M, Yang S, Chang H, Robinson C, Hunter K, Dobrzanski P, Jones-Bolin S, Pritchard S, Aimone L, Klein-Szanto A, Herbert JM, Bono F, Schaeffer P, Casellas P, Bourie B, Pili R, Isaacs J, Ator M, Hudkins R, Vaught J, Mallamo J, Dionne C. CEP-7055: a novel, orally active pan inhibitor of vascular endothelial growth factor receptor tyrosine kinases with potent antiangiogenic activity and antitumor efficacy in preclinical models. Cancer Res. 2003 Sep 15; 63(18):5978-91. PMID: 14522925.

Citations:
Mahloogi H, Gonz?lez-Guerrico AM, Lopez De Cicco R, Bassi DE, Goodrow T, Braunewell KH, Klein-Szanto AJ. Overexpression of the calcium sensor visinin-like protein-1 leads to a cAMP-mediated decrease of in vivo and in vitro growth and invasiveness of squamous cell carcinoma cells. Cancer Res. 2003 Aug 15; 63(16):4997-5004. PMID: 12941826.

Citations:
Grille SJ, Bellacosa A, Upson J, Klein-Szanto AJ, van Roy F, Lee-Kwon W, Donowitz M, Tsichlis PN, Larue L. The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines. Cancer Res. 2003 May 01; 63(9):2172-8. PMID: 12727836.

Citations:
Whitehead CM, Earle KA, Fetter J, Xu S, Hartman T, Chan DC, Zhao TL, Piazza G, Klein-Szanto AJ, Pamukcu R, Alila H, Bunn PA, Thompson WJ. Exisulind-induced apoptosis in a non-small cell lung cancer orthotopic lung tumor model augments docetaxel treatment and contributes to increased survival. Mol Cancer Ther. 2003 May; 2(5):479-88. PMID: 12748310.

Citations:
Miknyoczki SJ, Jones-Bolin S, Pritchard S, Hunter K, Zhao H, Wan W, Ator M, Bihovsky R, Hudkins R, Chatterjee S, Klein-Szanto A, Dionne C, Ruggeri B. Chemopotentiation of temozolomide, irinotecan, and cisplatin activity by CEP-6800, a poly(ADP-ribose) polymerase inhibitor. Mol Cancer Ther. 2003 Apr; 2(4):371-82. PMID: 12700281.

Citations:
Bassi DE, Mahloogi H, Lopez De Cicco R, Klein-Szanto A. Increased furin activity enhances the malignant phenotype of human head and neck cancer cells. Am J Pathol. 2003 Feb; 162(2):439-47. PMID: 12547702.

Citations:
Ozols RF, Daly MB, Klein-Szanto A, Hamilton TC, Bast RC, Brewer MA. Specific keynote: chemoprevention of ovarian cancer: the journey begins. Gynecol Oncol. 2003 Jan; 88(1 Pt 2):S59-66; discussion S67-70. PMID: 12586088.

Citations:
Liu SC, Bassi DE, Zhang SY, Holoran D, Conti CJ, Klein-Szanto AJ. Overexpression of cyclin D2 is associated with increased in vivo invasiveness of human squamous carcinoma cells. Mol Carcinog. 2002 Jul; 34(3):131-9. PMID: 12112307.

Citations:
Mercapide J, Lopez De Cicco R, Bassi DE, Castresana JS, Thomas G, Klein-Szanto AJP. Inhibition of furin-mediated processing results in suppression of astrocytoma cell growth and invasiveness. Clin Cancer Res. 2002 06; 8(6):1740-6. PMID: 12060611.

Citations:
Fedele M, Battista S, Kenyon L, Baldassarre G, Fidanza V, Klein-Szanto AJ, Parlow AF, Visone R, Pierantoni GM, Outwater E, Santoro M, Croce CM, Fusco A. Overexpression of the HMGA2 gene in transgenic mice leads to the onset of pituitary adenomas. Oncogene. 2002 May 09; 21(20):3190-8. PMID: 12082634.

Citations:
Klein WM, Hruban RH, Klein-Szanto AJ, Wilentz RE. Direct correlation between proliferative activity and dysplasia in pancreatic intraepithelial neoplasia (PanIN): additional evidence for a recently proposed model of progression. Mod Pathol. 2002 Apr; 15(4):441-7. PMID: 11950919.

Citations:
Mahloogi H, Bassi DE, Klein-Szanto AJ. Malignant conversion of non-tumorigenic murine skin keratinocytes overexpressing PACE4. Carcinogenesis. 2002 Apr; 23(4):565-72. PMID: 11960907.

Citations:
Altomare DA, Tanno S, De Rienzo A, Klein-Szanto AJ, Tanno S, Skele KL, Hoffman JP, Testa JR. Frequent activation of AKT2 kinase in human pancreatic carcinomas. J Cell Biochem. 2002; 87(4):470-6. PMID: 14735903.

Citations:
L?pez de Cicco R, Bassi DE, Page R, Klein-Szanto AJ. Furin expression in squamous cell carcinomas of the oral cavity and other sites evaluated by tissue microarray technology. Acta Odontol Latinoam. 2002; 15(1-2):29-37. PMID: 15208940.

Citations:
Bassi DE, Lopez De Cicco R, Mahloogi H, Zucker S, Thomas G, Klein-Szanto AJ. Furin inhibition results in absent or decreased invasiveness and tumorigenicity of human cancer cells. Proc Natl Acad Sci U S A. 2001 Aug 28; 98(18):10326-31. PMID: 11517338.

Citations:
Bassi DE, Mahloogi H, Al-Saleem L, Lopez De Cicco R, Ridge JA, Klein-Szanto AJ. Elevated furin expression in aggressive human head and neck tumors and tumor cell lines. Mol Carcinog. 2001 Aug; 31(4):224-32. PMID: 11536372.

Citations:
Baldassarre G, Fedele M, Battista S, Vecchione A, Klein-Szanto AJ, Santoro M, Waldmann TA, Azimi N, Croce CM, Fusco A. Onset of natural killer cell lymphomas in transgenic mice carrying a truncated HMGI-C gene by the chronic stimulation of the IL-2 and IL-15 pathway. Proc Natl Acad Sci U S A. 2001 Jul 03; 98(14):7970-5. PMID: 11427729.

Citations:
Piazza GA, Thompson WJ, Pamukcu R, Alila HW, Whitehead CM, Liu L, Fetter JR, Gresh WE, Klein-Szanto AJ, Farnell DR, Eto I, Grubbs CJ. Exisulind, a novel proapoptotic drug, inhibits rat urinary bladder tumorigenesis. Cancer Res. 2001 May 15; 61(10):3961-8. PMID: 11358813.

Citations:
Liu SC, Zhang SY, Babb JS, Ridge JA, Klein-Szanto AJ. Image cytometry of cyclin D1: a prognostic marker for head and neck squamous cell carcinomas. Cancer Epidemiol Biomarkers Prev. 2001 May; 10(5):455-9. PMID: 11352854.

Citations:
Amuthan G, Biswas G, Zhang SY, Klein-Szanto A, Vijayasarathy C, Avadhani NG. Mitochondria-to-nucleus stress signaling induces phenotypic changes, tumor progression and cell invasion. EMBO J. 2001 Apr 17; 20(8):1910-20. PMID: 11296224.

Citations:
Virmani J, Johnson EN, Klein-Szanto AJ, Funk CD. Role of 'platelet-type' 12-lipoxygenase in skin carcinogenesis. Cancer Lett. 2001 Jan 26; 162(2):161-5. PMID: 11146221.

Citations:
Lee K, Klein-Szanto AJ, Kruh GD. Analysis of the MRP4 drug resistance profile in transfected NIH3T3 cells. J Natl Cancer Inst. 2000 Dec 06; 92(23):1934-40. PMID: 11106685.

Citations:
Zhang SY, Liu SC, Johnson DG, Klein-Szanto AJ. E2F-1 gene transfer enhances invasiveness of human head and neck carcinoma cell lines. Cancer Res. 2000 Nov 01; 60(21):5972-6. PMID: 11085515.

Citations:
Joseph P, Long DJ, Klein-Szanto AJ, Jaiswal AK. Role of NAD(P)H:quinone oxidoreductase 1 (DT diaphorase) in protection against quinone toxicity. Biochem Pharmacol. 2000 Jul 15; 60(2):207-14. PMID: 10825465.

Citations:
Young NA, Ehya H, Klein-Szanto A, Litwin S, Smith MR, al-Saleem T. Differentiating large cell lymphoma from indolent small B-cell lymphoma in fine needle aspirates using p53, PCNA and transformed lymphocyte count. Acta Cytol. 2000 Jul-Aug; 44(4):592-603. PMID: 10934953.

Citations:
Bassi DE, Mahloogi H, Klein-Szanto AJ. The proprotein convertases furin and PACE4 play a significant role in tumor progression. Mol Carcinog. 2000 Jun; 28(2):63-9. PMID: 10900462.

Citations:
Bruening W, Giasson BI, Klein-Szanto AJ, Lee VM, Trojanowski JQ, Godwin AK. Synucleins are expressed in the majority of breast and ovarian carcinomas and in preneoplastic lesions of the ovary. Cancer. 2000 May 01; 88(9):2154-63. PMID: 10813729.

Citations:
Zhang SY, Liu SC, Al-Saleem LF, Holloran D, Babb J, Guo X, Klein-Szanto AJ. E2F-1: a proliferative marker of breast neoplasia. Cancer Epidemiol Biomarkers Prev. 2000 Apr; 9(4):395-401. PMID: 10794484.

Citations:
Liu SC, Klein-Szanto AJ. Markers of proliferation in normal and leukoplakic oral epithelia. Oral Oncol. 2000 Mar; 36(2):145-51. PMID: 10745166.

Citations:
Sauter ER, Ehya H, Babb J, Diamandis E, Daly M, Klein-Szanto A, Sigurdson E, Hoffman J, Malick J, Engstrom PF. Biological markers of risk in nipple aspirate fluid are associated with residual cancer and tumour size. Br J Cancer. 1999 Dec; 81(7):1222-7. PMID: 10584885.

Citations:
Riccio A, Aaltonen LA, Godwin AK, Loukola A, Percesepe A, Salovaara R, Masciullo V, Genuardi M, Paravatou-Petsotas M, Bassi DE, Ruggeri BA, Klein-Szanto AJ, Testa JR, Neri G, Bellacosa A. The DNA repair gene MBD4 (MED1) is mutated in human carcinomas with microsatellite instability. Nat Genet. 1999 Nov; 23(3):266-8. PMID: 10545939.

Citations:
Battista S, Fidanza V, Fedele M, Klein-Szanto AJ, Outwater E, Brunner H, Santoro M, Croce CM, Fusco A. The expression of a truncated HMGI-C gene induces gigantism associated with lipomatosis. Cancer Res. 1999 Oct 01; 59(19):4793-7. PMID: 10519386.

Citations:
Sauter ER, Nesbit M, Litwin S, Klein-Szanto AJ, Cheffetz S, Herlyn M. Antisense cyclin D1 induces apoptosis and tumor shrinkage in human squamous carcinomas. Cancer Res. 1999 Oct 01; 59(19):4876-81. PMID: 10519399.

Citations:
Miknyoczki SJ, Chang H, Klein-Szanto A, Dionne CA, Ruggeri BA. The Trk tyrosine kinase inhibitor CEP-701 (KT-5555) exhibits significant antitumor efficacy in preclinical xenograft models of human pancreatic ductal adenocarcinoma. Clin Cancer Res. 1999 Aug; 5(8):2205-12. PMID: 10473107.

Citations:
Miknyoczki SJ, Dionne CA, Klein-Szanto AJ, Ruggeri BA. The novel Trk receptor tyrosine kinase inhibitor CEP-701 (KT-5555) exhibits antitumor efficacy against human pancreatic carcinoma (Panc1) xenograft growth and in vivo invasiveness. Ann N Y Acad Sci. 1999 Jun 30; 880:252-62. PMID: 10415871.

Citations:
Miknyoczki SJ, Lang D, Huang L, Klein-Szanto AJ, Dionne CA, Ruggeri BA. Neurotrophins and Trk receptors in human pancreatic ductal adenocarcinoma: expression patterns and effects on in vitro invasive behavior. Int J Cancer. 1999 May 05; 81(3):417-27. PMID: 10209957.

Citations:
Plank TL, Logginidou H, Klein-Szanto A, Henske EP. The expression of hamartin, the product of the TSC1 gene, in normal human tissues and in TSC1- and TSC2-linked angiomyolipomas. Mod Pathol. 1999 May; 12(5):539-45. PMID: 10349994.

Citations:
Sauter ER, Nesbit M, Watson JC, Klein-Szanto A, Litwin S, Herlyn M. Vascular endothelial growth factor is a marker of tumor invasion and metastasis in squamous cell carcinomas of the head and neck. Clin Cancer Res. 1999 Apr; 5(4):775-82. PMID: 10213212.

Citations:
Liu SC, Hu Y, Sauter ER, Clapper ML, Chen SY, Lanfranchi HE, Engstrom PF, Klein-Szanto AJ. Image analysis of p53 and cyclin D1 expression in premalignant lesions of the oral mucosa. Anal Quant Cytol Histol. 1999 Apr; 21(2):166-73. PMID: 10560487.

Citations:
Gude RP, Binda MM, Presas HL, Klein-Szanto AJ, Bonfil RD. Studies on the mechanisms responsible for inhibition of experimental metastasis of B16-F10 murine melanoma by pentoxifylline. J Biomed Sci. 1999 Mar-Apr; 6(2):133-41. PMID: 10087444.

Citations:
Sauter ER, Klein-Szanto AJ, Atillasoy E, Montone KT, Goodrow T, Binder RL, Seykora JT, Herlyn M. Ultraviolet B-induced squamous epithelial and melanocytic cell changes in a xenograft model of cancer development in human skin. Mol Carcinog. 1998 Nov; 23(3):168-74. PMID: 9833777.

Citations:
Lifsted T, Le Voyer T, Williams M, Muller W, Klein-Szanto A, Buetow KH, Hunter KW. Identification of inbred mouse strains harboring genetic modifiers of mammary tumor age of onset and metastatic progression. Int J Cancer. 1998 Aug 12; 77(4):640-4. PMID: 9679770.

Citations:
Joseph P, Klein-Szanto AJ, Jaiswal AK. Hydroquinones cause specific mutations and lead to cellular transformation and in vivo tumorigenesis. Br J Cancer. 1998 Aug; 78(3):312-20. PMID: 9703276.

Citations:
Ma J, Fei ZL, Klein-Szanto A, Gallo JM. Modulation of angiogenesis by human glioma xenograft models that differentially express vascular endothelial growth factor. Clin Exp Metastasis. 1998 Aug; 16(6):559-68. PMID: 9872603.

Citations:
Zhang S, Klein-Szanto A. [p53 gene mutations in mouse skin tumors induced by DMBA-TPA-MNNG]. Zhonghua Bing Li Xue Za Zhi. 1998 Aug; 27(4):298-300. PMID: 11245002.

Citations:
Tanno S, Obara T, Fujii T, Mizukami Y, Shudo R, Nishino N, Ura H, Klein-Szanto AJ, Kohgo Y. Proliferative potential and K-ras mutation in epithelial hyperplasia of the gallbladder in patients with anomalous pancreaticobiliary ductal union. Cancer. 1998 Jul 15; 83(2):267-75. PMID: 9669809.

Citations:
Kisielewski AE, Xiao GH, Liu SC, Klein-Szanto AJ, Novara M, Sina J, Bleicher K, Yeung RS, Goodrow TL. Analysis of the FHIT gene and its product in squamous cell carcinomas of the head and neck. Oncogene. 1998 Jul 09; 17(1):83-91. PMID: 9671317.

Citations:
Liu SC, Sauter ER, Clapper ML, Feldman RS, Levin L, Chen SY, Yen TJ, Ross E, Engstrom PF, Klein-Szanto AJ. Markers of cell proliferation in normal epithelia and dysplastic leukoplakias of the oral cavity. Cancer Epidemiol Biomarkers Prev. 1998 Jul; 7(7):597-603. PMID: 9681528.

Citations:
Law SF, Zhang YZ, Klein-Szanto AJ, Golemis EA. Cell cycle-regulated processing of HEF1 to multiple protein forms differentially targeted to multiple subcellular compartments. Mol Cell Biol. 1998 Jun; 18(6):3540-51. PMID: 9584194.

Citations:
Radjendirane V, Joseph P, Lee YH, Kimura S, Klein-Szanto AJ, Gonzalez FJ, Jaiswal AK. Disruption of the DT diaphorase (NQO1) gene in mice leads to increased menadione toxicity. J Biol Chem. 1998 Mar 27; 273(13):7382-9. PMID: 9516435.

Citations:
Hubbard FC, Goodrow TL, Liu SC, Brilliant MH, Basset P, Mains RE, Klein-Szanto AJ. Expression of PACE4 in chemically induced carcinomas is associated with spindle cell tumor conversion and increased invasive ability. Cancer Res. 1997 Dec 01; 57(23):5226-31. PMID: 9393739.

Citations:
Henske EP, Wessner LL, Golden J, Scheithauer BW, Vortmeyer AO, Zhuang Z, Klein-Szanto AJ, Kwiatkowski DJ, Yeung RS. Loss of tuberin in both subependymal giant cell astrocytomas and angiomyolipomas supports a two-hit model for the pathogenesis of tuberous sclerosis tumors. Am J Pathol. 1997 Dec; 151(6):1639-47. PMID: 9403714.

Citations:
Xiao GH, Jin F, Klein-Szanto AJ, Goodrow TL, Linehan MW, Yeung RS. The FHIT gene product is highly expressed in the cytoplasm of renal tubular epithelium and is down-regulated in kidney cancers. Am J Pathol. 1997 Dec; 151(6):1541-7. PMID: 9403704.

Citations:
Yeung RS, Katsetos CD, Klein-Szanto A. Subependymal astrocytic hamartomas in the Eker rat model of tuberous sclerosis. Am J Pathol. 1997 Nov; 151(5):1477-86. PMID: 9358774.

Citations:
Smith MK, Goral MA, Wright JH, Matrisian LM, Morris RJ, Klein-Szanto AJ, Gilmour SK. Ornithine decarboxylase overexpression leads to increased epithelial tumor invasiveness. Cancer Res. 1997 Jun 01; 57(11):2104-8. PMID: 9187103.

Citations:
Zhang SY, Liu SC, Goodrow T, Morris R, Klein-Szanto AJ. Increased expression of G1 cyclins and cyclin-dependent kinases during tumor progression of chemically induced mouse skin neoplasms. Mol Carcinog. 1997 Mar; 18(3):142-52. PMID: 9115584.

Citations:
Ruggeri BA, Huang L, Berger D, Chang H, Klein-Szanto AJ, Goodrow T, Wood M, Obara T, Heath CW, Lynch H. Molecular pathology of primary and metastatic ductal pancreatic lesions: analyses of mutations and expression of the p53, mdm-2, and p21/WAF-1 genes in sporadic and familial lesions. Cancer. 1997 Feb 15; 79(4):700-16. PMID: 9024708.

Citations:
Sauter ER, Ross E, Daly M, Klein-Szanto A, Engstrom PF, Sorling A, Malick J, Ehya H. Nipple aspirate fluid: a promising non-invasive method to identify cellular markers of breast cancer risk. Br J Cancer. 1997; 76(4):494-501. PMID: 9275027.

Citations:
Mitsunaga S, Clapper M, Litwin S, Watts P, Bauer B, Klein-Szanto AJ. Chemopreventive effect of difluoromethylornithine (DFMO) on mouse skin squamous cell carcinomas induced by benzo(a)pyrene. J Cell Biochem Suppl. 1997; 28-29:81-9. PMID: 9589352.

Citations:
Medcalf AS, Klein-Szanto AJ, Cristofalo VJ. Expression of p21 is not required for senescence of human fibroblasts. Cancer Res. 1996 Oct 15; 56(20):4582-5. PMID: 8840965.

Citations:
Taguchi T, Zhou JY, Feder M, Litwin S, Klein-Szanto AJ, Testa JR. Detection of aneuploidy in interphase nuclei from non-small cell lung carcinomas by fluorescence in situ hybridization using chromosome-specific repetitive DNA probes. Cancer Genet Cytogenet. 1996 Jul 15; 89(2):120-5. PMID: 8697416.

Citations:
Devineni D, Klein-Szanto A, Gallo JM. Uptake of temozolomide in a rat glioma model in the presence and absence of the angiogenesis inhibitor TNP-470. Cancer Res. 1996 May 01; 56(9):1983-7. PMID: 8616836.

Citations:
Huang L, Goodrow TL, Zhang SY, Klein-Szanto AJ, Chang H, Ruggeri BA. Deletion and mutation analyses of the P16/MTS-1 tumor suppressor gene in human ductal pancreatic cancer reveals a higher frequency of abnormalities in tumor-derived cell lines than in primary ductal adenocarcinomas. Cancer Res. 1996 Mar 01; 56(5):1137-41. PMID: 8640773.

Citations:
Huang L, Lang D, Geradts J, Obara T, Klein-Szanto AJ, Lynch HT, Ruggeri BA. Molecular and immunochemical analyses of RB1 and cyclin D1 in human ductal pancreatic carcinomas and cell lines. Mol Carcinog. 1996 Feb; 15(2):85-95. PMID: 8599583.

Citations:
Miknyoczki SJ, Klein-Szanto AJ, Ruggeri BA. Neurotrophin-Trk receptor interactions in neoplasia: a possible role in interstitial and perineural invasion in ductal pancreatic cancer. Crit Rev Oncog. 1996; 7(1-2):89-100. PMID: 9109499.

Citations:
Devineni D, Klein-Szanto A, Gallo JM. In vivo microdialysis to characterize drug transport in brain tumors: analysis of methotrexate uptake in rat glioma-2 (RG-2)-bearing rats. Cancer Chemother Pharmacol. 1996; 38(6):499-507. PMID: 8823490.

Citations:
Peralta Soler A, Knudsen KA, Jaurand MC, Johnson KR, Wheelock MJ, Klein-Szanto AJ, Salazar H. The differential expression of N-cadherin and E-cadherin distinguishes pleural mesotheliomas from lung adenocarcinomas. Hum Pathol. 1995 Dec; 26(12):1363-9. PMID: 8522310.

Citations:
Bianchi AB, Mitsunaga SI, Cheng JQ, Klein WM, Jhanwar SC, Seizinger B, Kley N, Klein-Szanto AJ, Testa JR. High frequency of inactivating mutations in the neurofibromatosis type 2 gene (NF2) in primary malignant mesotheliomas. Proc Natl Acad Sci U S A. 1995 Nov 21; 92(24):10854-8. PMID: 7479897.

Citations:
Sirotkin AM, Edelmann W, Cheng G, Klein-Szanto A, Kucherlapati R, Skoultchi AI. Mice develop normally without the H1(0) linker histone. Proc Natl Acad Sci U S A. 1995 Jul 03; 92(14):6434-8. PMID: 7604008.

Citations:
Mitsunaga SI, Zhang SY, Ruggeri BA, Gimenez-Conti I, Robles AI, Conti CJ, Klein-Szanto AJ. Positive immunohistochemical staining of p53 and cyclin D in advanced mouse skin tumors, but not in precancerous lesions produced by benzo[a]pyrene. Carcinogenesis. 1995 Jul; 16(7):1629-35. PMID: 7542177.

Citations:
Sauter ER, Ridge JA, Trock B, Cleveland D, Whitley KV, Mohr RM, Klein-Szanto A. Overexpression of the p53 gene in primary and metastatic head and neck carcinomas. Laryngoscope. 1995 Jun; 105(6):653-6. PMID: 7769953.

Citations:
Zenklusen JC, Thompson JC, Klein-Szanto AJ, Conti CJ. Frequent loss of heterozygosity in human primary squamous cell and colon carcinomas at 7q31.1: evidence for a broad range tumor suppressor gene. Cancer Res. 1995 Mar 15; 55(6):1347-50. PMID: 7882334.

Citations:
Zhang SY, Bauer B, Mitsunaga S, Goodrow TL, Klein-Szanto AJ. Lack of concordant p53 mutations in some paired primary and metastatic mouse squamous cell carcinomas induced by chemical carcinogenesis. Mol Carcinog. 1995 Feb; 12(2):77-81. PMID: 7662119.

Citations:
Devineni D, Klein-Szanto A, Gallo JM. Tissue distribution of methotrexate following administration as a solution and as a magnetic microsphere conjugate in rats bearing brain tumors. J Neurooncol. 1995; 24(2):143-52. PMID: 7562001.

Citations:
Zhang SY, Caamano J, Cooper F, Guo X, Klein-Szanto AJ. Immunohistochemistry of cyclin D1 in human breast cancer. Am J Clin Pathol. 1994 Nov; 102(5):695-8. PMID: 7942638.

Citations:
Sauter ER, Cleveland D, Trock B, Ridge JA, Klein-Szanto AJ. p53 is overexpressed in fifty percent of pre-invasive lesions of head and neck epithelium. Carcinogenesis. 1994 Oct; 15(10):2269-74. PMID: 7955065.

Citations:
Zhang SY, Klein-Szanto AJ, Sauter ER, Shafarenko M, Mitsunaga S, Nobori T, Carson DA, Ridge JA, Goodrow TL. Higher frequency of alterations in the p16/CDKN2 gene in squamous cell carcinoma cell lines than in primary tumors of the head and neck. Cancer Res. 1994 Oct 01; 54(19):5050-3. PMID: 7923115.

Citations:
Gwin JL, Klein-Szanto AJ, Zhang SY, Agarwal P, Rogatko A, Keller SM. Loss of blood group antigen A in non-small cell lung cancer. Ann Surg Oncol. 1994 Sep; 1(5):423-7. PMID: 7850544.

Citations:
Klein-Szanto AJ, Silvers WK, Mintz B. Ultraviolet radiation-induced malignant skin melanoma in melanoma-susceptible transgenic mice. Cancer Res. 1994 Sep 01; 54(17):4569-72. PMID: 8062242.

Citations:
Ruggeri BA, Bauer B, Zhang SY, Klein-Szanto AJ. Murine squamous cell carcinoma cell lines produced by a complete carcinogenesis protocol with benzo[a]pyrene exhibit characteristic p53 mutations and the absence of H-ras and cyl 1/cyclin D1 abnormalities. Carcinogenesis. 1994 Aug; 15(8):1613-9. PMID: 8055640.

Citations:
Patamalai B, Burow DL, Gimenez-Conti I, Zenklusen JC, Conti CJ, Klein-Szanto AJ, Fischer SM. Altered expression of transforming growth factor-beta 1 mRNA and protein in mouse skin carcinogenesis. Mol Carcinog. 1994 Apr; 9(4):220-9. PMID: 8148055.

Citations:
Zhang SY, Ruggeri B, Agarwal P, Sorling AF, Obara T, Ura H, Namiki M, Klein-Szanto AJ. Immunohistochemical analysis of p53 expression in human pancreatic carcinomas. Arch Pathol Lab Med. 1994 Feb; 118(2):150-4. PMID: 8311654.

Citations:
Bianchi AB, Hara T, Ramesh V, Gao J, Klein-Szanto AJ, Morin F, Menon AG, Trofatter JA, Gusella JF, Seizinger BR, et al. Mutations in transcript isoforms of the neurofibromatosis 2 gene in multiple human tumour types. Nat Genet. 1994 Feb; 6(2):185-92. PMID: 8162073.

Citations:
Mintz B, Silvers WK, Klein-Szanto AJ. Histopathogenesis of malignant skin melanoma induced in genetically susceptible transgenic mice. Proc Natl Acad Sci U S A. 1993 Oct 01; 90(19):8822-6. PMID: 8415614.

Citations:
Garcia de Palazzo I, Klein-Szanto A, Weiner LM. Immunohistochemical detection of c-erbB-2 expression by neoplastic human tissue using monospecific and bispecific monoclonal antibodies. Int J Biol Markers. 1993 Oct-Dec; 8(4):233-9. PMID: 7908024.

Citations:
Iizasa T, Momiki S, Bauer B, Caamano J, Metcalf R, Lechner J, Harris CC, Klein-Szanto AJ. Invasive tumors derived from xenotransplanted, immortalized human cells after in vivo exposure to chemical carcinogens. Carcinogenesis. 1993 Sep; 14(9):1789-94. PMID: 8403201.

Citations:
Caamano J, Zhang SY, Rosvold EA, Bauer B, Klein-Szanto AJ. p53 alterations in human squamous cell carcinomas and carcinoma cell lines. Am J Pathol. 1993 Apr; 142(4):1131-9. PMID: 7682763.

Citations:
Ruggeri B, DiRado M, Zhang SY, Bauer B, Goodrow T, Klein-Szanto AJ. Benzo[a]pyrene-induced murine skin tumors exhibit frequent and characteristic G to T mutations in the p53 gene. Proc Natl Acad Sci U S A. 1993 Feb 01; 90(3):1013-7. PMID: 8430068.

Citations:
Klein-Szanto AJ, Ruggeri B, Bianchi A, Conti CJ. Cellular and molecular changes during mouse skin tumor progression. Recent Results Cancer Res. 1993; 128:193-204. PMID: 8356319.

Citations:
Itoiz ME, Larcher F, Lanfranchi HE, Diaz J, Klein-Szanto AJ, Conti CJ. Simultaneous PAGE, immunoblotting, and immunohistochemical analysis of differentiation associated keratins in lesions of the oral mucosa. Acta Odontol Latinoam. 1993; 7(2):13-22. PMID: 11885243.

Citations:
Hino O, Klein-Szanto AJ, Freed JJ, Testa JR, Brown DQ, Vilensky M, Yeung RS, Tartof KD, Knudson AG. Spontaneous and radiation-induced renal tumors in the Eker rat model of dominantly inherited cancer. Proc Natl Acad Sci U S A. 1993 Jan 01; 90(1):327-31. PMID: 8419937.

Citations:
Mintz B, Klein-Szanto AJ. Malignancy of eye melanomas originating in the retinal pigment epithelium of transgenic mice after genetic ablation of choroidal melanocytes. Proc Natl Acad Sci U S A. 1992 Dec 01; 89(23):11421-5. PMID: 1454829.

Citations:
Zucker S, Lysik RM, Malik M, Bauer BA, Caamano J, Klein-Szanto AJ. Secretion of gelatinases and tissue inhibitors of metalloproteinases by human lung cancer cell lines and revertant cell lines: not an invariant correlation with metastasis. Int J Cancer. 1992 Sep 30; 52(3):366-71. PMID: 1399111.

Citations:
Eisenberg BL, Lanciano RM, Nussbaum ML, Klein-Szanto A, Taylor DD. Intraoperative liver radiation after partial hepatectomy in a rat model. J Surg Res. 1992 Sep; 53(3):287-92. PMID: 1382153.

Citations:
Klein-Szanto AJ, Iizasa T, Momiki S, Garcia-Palazzo I, Caamano J, Metcalf R, Welsh J, Harris CC. A tobacco-specific N-nitrosamine or cigarette smoke condensate causes neoplastic transformation of xenotransplanted human bronchial epithelial cells. Proc Natl Acad Sci U S A. 1992 Aug 01; 89(15):6693-7. PMID: 1323115.

Citations:
Ruggeri B, Zhang SY, Caamano J, DiRado M, Flynn SD, Klein-Szanto AJ. Human pancreatic carcinomas and cell lines reveal frequent and multiple alterations in the p53 and Rb-1 tumor-suppressor genes. Oncogene. 1992 Aug; 7(8):1503-11. PMID: 1630814.

Citations:
Klein-Szanto AJ, Ura H, Momiki S, Bonfil D, Litwin S. Effects of formaldehyde on xenotransplanted human respiratory epithelium. Res Rep Health Eff Inst. 1992 Jul; (51):1-17; discussion 19-27. PMID: 1524735.

Citations:
Ruggeri B, Caamano J, Slaga TJ, Conti CJ, Nelson WJ, Klein-Szanto AJ. Alterations in the expression of uvomorulin and Na+,K(+)-adenosine triphosphatase during mouse skin tumor progression. Am J Pathol. 1992 May; 140(5):1179-85. PMID: 1316085.

Citations:
Conti CJ, Bianchi AB, Navone NM, Ruggieri BA, Caamano J, Goodrow T, Klein-Szanto AJ. Tumor suppressor genes in squamous cell carcinoma. Prog Clin Biol Res. 1992; 376:85-101. PMID: 1528931.

Citations:
Klein-Szanto AJ. Carcinogenic effects of chemotherapeutic compounds. Prog Clin Biol Res. 1992; 374:167-74. PMID: 1620702.

Citations:
Ruggeri B, Zhang SY, Klein-Szanto AJ. Molecular and cytogenetic alterations in human pancreatic cancer: the role of tumor suppressor genes. Prog Clin Biol Res. 1992; 376:245-60. PMID: 1528921.

Citations:
Caamano J, Ruggeri BA, Klein-Szanto AJ. A catalog of p53 alterations in selected human and laboratory animal neoplasms. Prog Clin Biol Res. 1992; 376:331-55. PMID: 1528927.

Citations:
Caamano J, DiRado M, Iizasa T, Momiki S, Fernandes E, Ashendel C, Noda M, Klein-Szanto AJ. Partial suppression of tumorigenicity in a human lung cancer cell line transfected with Krev-1. Mol Carcinog. 1992; 6(4):252-9. PMID: 1485916.

Citations:
Ruggeri B, Caamano J, Goodrow T, DiRado M, Bianchi A, Trono D, Conti CJ, Klein-Szanto AJ. Alterations of the p53 tumor suppressor gene during mouse skin tumor progression. Cancer Res. 1991 Dec 15; 51(24):6615-21. PMID: 1742735.

Citations:
Caamano J, Ruggeri B, Momiki S, Sickler A, Zhang SY, Klein-Szanto AJ. Detection of p53 in primary lung tumors and nonsmall cell lung carcinoma cell lines. Am J Pathol. 1991 Oct; 139(4):839-45. PMID: 1656762.

Citations:
Buchmann A, Ruggeri B, Klein-Szanto AJ, Balmain A. Progression of squamous carcinoma cells to spindle carcinomas of mouse skin is associated with an imbalance of H-ras alleles on chromosome 7. Cancer Res. 1991 Aug 01; 51(15):4097-101. PMID: 1855225.

Citations:
Pfeifer AM, Jones RT, Bowden PE, Mann D, Spillare E, Klein-Szanto AJ, Trump BF, Harris CC. Human bronchial epithelial cells transformed by the c-raf-1 and c-myc protooncogenes induce multidifferentiated carcinomas in nude mice: a model for lung carcinogenesis. Cancer Res. 1991 Jul 15; 51(14):3793-801. PMID: 1712250.

Citations:
Chiba M, Aldaz CM, Conti CJ, Klein-Szanto AJ. Metastatic potential of mouse skin carcinomas produced by different protocols of chemical carcinogenesis. Invasion Metastasis. 1991; 11(5):288-96. PMID: 1686875.

Citations:
Basolo F, Elliott J, Tait L, Chen XQ, Maloney T, Russo IH, Pauley R, Momiki S, Caamano J, Klein-Szanto AJ, et al. Transformation of human breast epithelial cells by c-Ha-ras oncogene. Mol Carcinog. 1991; 4(1):25-35. PMID: 2009132.

Citations:
Klein-Szanto A, Bradl M, Porter S, Mintz B. Melanosis and associated tumors in transgenic mice. Proc Natl Acad Sci U S A. 1991 Jan 01; 88(1):169-73. PMID: 1846037.

Citations:
Bradl M, Klein-Szanto A, Porter S, Mintz B. Malignant melanoma in transgenic mice. Proc Natl Acad Sci U S A. 1991 Jan 01; 88(1):164-8. PMID: 1846036.

Citations:
Momiki S, Baba M, Caamano J, Iizasa T, Nakajima M, Yamaguchi Y, Klein-Szanto A. In vivo and in vitro invasiveness of human lung carcinoma cell lines. Invasion Metastasis. 1991; 11(2):66-75. PMID: 1655672.

Citations:
Morris RJ, Fischer SM, Klein-Szanto AJ, Slaga TJ. Subpopulations of primary adult murine epidermal basal cells sedimented on density gradients. Cell Tissue Kinet. 1990 Nov; 23(6):587-602. PMID: 2177380.

Citations:
Lazo PA, Klein-Szanto AJ, Tsichlis PN. T-cell lymphoma lines derived from rat thymomas induced by Moloney murine leukemia virus: phenotypic diversity and its implications. J Virol. 1990 Aug; 64(8):3948-59. PMID: 2196385.

Citations:
Bonfil RD, Momiki S, Fridman R, Reich R, Reddel R, Harris CC, Klein-Szanto A. Enhancement of the invasive ability of a transformed human bronchial epithelial cell line by 12-O-tetradecanoyl-phorbol-13-acetate and diacylglycerol. Carcinogenesis. 1989 Dec; 10(12):2335-8. PMID: 2556220.

Citations:
Klein-Szanto AJ, Larcher F, Bonfil RD, Conti CJ. Multistage chemical carcinogenesis protocols produce spindle cell carcinomas of the mouse skin. Carcinogenesis. 1989 Nov; 10(11):2169-72. PMID: 2478310.

Citations:
Ura H, Bonfil RD, Reich R, Reddel R, Pfeifer A, Harris CC, Klein-Szanto AJ. Expression of type IV collagenase and procollagen genes and its correlation with the tumorigenic, invasive, and metastatic abilities of oncogene-transformed human bronchial epithelial cells. Cancer Res. 1989 Aug 15; 49(16):4615-21. PMID: 2545347.

Citations:
Bonfil RD, Momiki S, Conti CJ, Klein-Szanto AJ. Benzoyl peroxide enhances the invasive ability of a mouse epidermal carcinoma cell line. Int J Cancer. 1989 Jul 15; 44(1):165-9. PMID: 2744887.

Citations:
Bonfil RD, Reddel RR, Ura H, Reich R, Fridman R, Harris CC, Klein-Szanto AJP. Invasive and metastatic potential of a v-Ha-ras-transformed human bronchial epithelial cell line. J Natl Cancer Inst. 1989 04 19; 81(8):587-94. PMID: 2539488.

Citations:
Klein-Szanto AJ. Morphological evaluation of the effects of carcinogens and promoters. Prog Clin Biol Res. 1989; 298:45-62. PMID: 2664814.

Citations:
Klein-Szanto AJ, Ura H, Resau J. Formaldehyde-induced lesions of xenotransplanted human nasal respiratory epithelium. Toxicol Pathol. 1989; 17(1 Pt 1):33-7. PMID: 2749134.

Citations:
Ura H, Nowak P, Litwin S, Watts P, Bonfil RD, Klein-Szanto AJ. Effects of formaldehyde on normal xenotransplanted human tracheobronchial epithelium. Am J Pathol. 1989 Jan; 134(1):99-106. PMID: 2913828.

Citations:
Klein-Szanto AJ. Pathology of human and experimental skin tumors. Carcinog Compr Surv. 1989; 11:19-53. PMID: 2646016.

Citations:
Baba M, Obara T, Bonfil RD, Yamaguchi Y, Trump BF, Resau J, Klein-Szanto AJ. Resistance to serum-induced terminal differentiation in normal human tracheobronchial epithelial cells after in vivo exposure to 7,12-dimethylbenz[a]anthracene. Jpn J Cancer Res. 1988 Jun; 79(6):734-41. PMID: 3137200.

Citations:
Obara T, Baba M, Yamaguchi Y, Fuchs E, Resau JH, Trump BF, Klein-Szanto AJ. Localization of keratin mRNA in human tracheobronchial epithelium and bronchogenic carcinomas by in situ hybridization. Am J Pathol. 1988 Jun; 131(3):519-29. PMID: 2454581.

Citations:
Klein-Szanto AJ, Boysen M, Reith A. Keratin and involucrin in preneoplastic and neoplastic lesions. Distribution in the nasal mucosa of nickel workers. Arch Pathol Lab Med. 1987 Nov; 111(11):1057-61. PMID: 2444190.

Citations:
Aldaz CM, Conti CJ, Klein-Szanto AJ, Slaga TJ. Progressive dysplasia and aneuploidy are hallmarks of mouse skin papillomas: relevance to malignancy. Proc Natl Acad Sci U S A. 1987 Apr; 84(7):2029-32. PMID: 3104907.

Citations:
Patskan GJ, Klein-Szanto AJ, Phillips JL, Slaga TJ. Metastasis from squamous cell carcinomas of SENCAR mouse skin produced by complete carcinogenesis. Cancer Lett. 1987 Feb; 34(2):121-7. PMID: 3815325.

Citations:
Baba M, Klein-Szanto AJ, Trono D, Obara T, Yoakum GH, Masui T, Harris CC. Preneoplastic and neoplastic growth of xenotransplanted lung-derived human cell lines using deepithelialized rat tracheas. Cancer Res. 1987 Jan 15; 47(2):573-8. PMID: 3791242.

Citations:
Fern?ndez Alonso GI, Obara T, Klein-Szanto AJ, Conti CJ. Antibodies reacting against cytoskeletal proteins in Waldenstrom's disease. Allergol Immunopathol (Madr). 1986 Nov-Dec; 14(6):467-72. PMID: 2435137.

Citations:
Conti CJ, Aldaz CM, O'Connell J, Klein-Szanto AJ, Slaga TJ. Aneuploidy, an early event in mouse skin tumor development. Carcinogenesis. 1986 Nov; 7(11):1845-8. PMID: 3769132.

Citations:
Klein-Szanto AJ, Conti CJ, Aldaz CM, Clapp N, Nesnow S, Slaga TJ. Effects of chronic topical application of 12-O-tetradecanoylphorbol-13-acetate on the skin and internal organs of SENCAR mice. Environ Health Perspect. 1986 Sep; 68:75-80. PMID: 3780635.

Citations:
Conti CJ, Fries JW, Aldaz CM, Klein-Szanto AJ, Slaga TJ. Allogeneic transplantation of normal epidermal cells and squamous cell carcinomas in SENCAR mice. Environ Health Perspect. 1986 Sep; 68:125-9. PMID: 3536472.

Citations:
Aldaz CM, Conti CJ, O'Connell J, Yuspa SH, Klein-Szanto AJ, Slaga TJ. Cytogenetic evidence for gene amplification in mouse skin carcinogenesis. Cancer Res. 1986 Jul; 46(7):3565-8. PMID: 3708588.

Citations:
O'Connell JF, Klein-Szanto AJ, DiGiovanni DM, Fries JW, Slaga TJ. Enhanced malignant progression of mouse skin tumors by the free-radical generator benzoyl peroxide. Cancer Res. 1986 Jun; 46(6):2863-5. PMID: 3084079.

Citations:
Klein-Szanto AJ, Baba M, Trono D, Obara T, Resau J, Trump BF. Epidermoid metaplasias of xenotransplanted human tracheobronchial epithelium. Carcinogenesis. 1986 Jun; 7(6):987-94. PMID: 2423266.

Citations:
Itoiz ME, Conti CJ, Gimenez IB, Lanfranchi HE, Fernandez-Alonso GI, Klein-Szanto AJ. Immunodetection of involucrin in lesions of the oral mucosa. J Oral Pathol. 1986 Apr; 15(4):205-8. PMID: 3088235.

Citations:
O'Connell JF, Klein-Szanto AJ, Digiovanni DM, Fries JW, Slaga TJ. Malignant progression of mouse skin papillomas treated with ethylnitrosourea, N-methyl-N'-nitro-N-nitrosoguanidine, or 12-O-tetradecanoylphorbol-13-acetate. Cancer Lett. 1986 Mar; 30(3):269-74. PMID: 2870794.

Citations:
Obara T, Conti CJ, Baba M, Resau JH, Trifillis AL, Trump BF, Klein-Szanto AJ. Rapid detection of xenotransplanted human tissues using in situ hybridization. Am J Pathol. 1986 Mar; 122(3):386-91. PMID: 3513599.

Citations:
Aldaz CM, Conti CJ, Klein-Szanto AJ, Slaga TJ. A direct cytogenetic technique for mouse skin carcinomas and papillomas. Cancer Genet Cytogenet. 1986 Feb 15; 20(3-4):223-9. PMID: 3943063.

Citations:
Chiba M, Maley MA, Klein-Szanto AJ. Sequential study of gamma-glutamyltransferase during complete and two-stage mouse skin carcinogenesis. Cancer Res. 1986 Jan; 46(1):259-63. PMID: 2866031.

Citations:
Conti CJ, Clapp N, Klein-Szanto AJ, Nesnow S, Slaga TJ. Survival curves and incidence of neoplastic and non-neoplastic disease in SENCAR mice. Carcinogenesis. 1985 Nov; 6(11):1649-52. PMID: 4053283.

Citations:
Kehrer JP, Klein-Szanto AJ. Enhanced acute lung damage in mice following administration of 1,3-bis(2-chloroethyl)-1-nitrosourea. Cancer Res. 1985 Nov; 45(11 Pt 2):5707-13. PMID: 4053044.

Citations:
Aldaz CM, Conti CJ, Gimenez IB, Slaga TJ, Klein-Szanto AJ. Cutaneous changes during prolonged application of 12-O-tetradecanoylphorbol-13-acetate on mouse skin and residual effects after cessation of treatment. Cancer Res. 1985 Jun; 45(6):2753-9. PMID: 3986807.

Citations:
Itoiz ME, Conti CJ, Lanfranchi HE, Mamrack M, Klein-Szanto AJ. Immunohistochemical detection of filaggrin in preneoplastic and neoplastic lesions of the human oral mucosa. Am J Pathol. 1985 Jun; 119(3):456-61. PMID: 4014435.

Citations:
Fischer SM, Klein-Szanto AJ, Adams LM, Slaga TJ. The first stage and complete promoting activity of retinoic acid but not the analog RO-10-9359. Carcinogenesis. 1985 Apr; 6(4):575-8. PMID: 2580648.

Citations:
Klein-Szanto AJ. Distribution of keratins and involucrin in human fetal oral epithelia. Acta Odontol Latinoam. 1985; 2(2):35-41. PMID: 16245629.

Citations:
Klein-Szanto AJ, Marchok AC, Terzaghi M. In vivo studies on enhancement and promotion of respiratory tract carcinogenesis: studies with heterotopic tracheal transplants. Carcinog Compr Surv. 1985; 8:119-30. PMID: 3921250.

Citations:
Klein-Szanto AJ, Barr RJ, Reiners JJ, Mamrack MD. Filaggrin distribution in keratoacanthomas and squamous cell carcinoma. Arch Pathol Lab Med. 1984 Nov; 108(11):888-90. PMID: 6385922.

Citations:
Klein-Szanto AJ, Chiba M, Lee SU, Conti CJ, Thetford D. Keratinocyte damage produced by 12-O-tetradecanoylphorbol-13-acetate in rodent epidermis. Carcinogenesis. 1984 Nov; 5(11):1459-65. PMID: 6488471.

Citations:
Mamrack MD, Klein-Szanto AJ, Reiners JJ, Slaga TJ. Alteration in the distribution of the epidermal protein filaggrin during two-stage chemical carcinogenesis in the SENCAR mouse skin. Cancer Res. 1984 Jun; 44(6):2634-41. PMID: 6426783.

Citations:
Klein-Szanto AJ, Pal BC, Terzaghi M, Marchok AC. Heterotopic tracheal transplants: techniques and applications. Environ Health Perspect. 1984 Jun; 56:75-86. PMID: 6383803.

Citations:
Chiba M, Slaga TJ, Klein-Szanto AJ. A morphometric study of dedifferentiated and involutional dark keratinocytes in 12-O-tetradecanoylphorbol-13-acetate-treated mouse epidermis. Cancer Res. 1984 Jun; 44(6):2711-7. PMID: 6202399.

Citations:
Shiba M, Ohiwa T, Klein-Szanto AJ. Lectin-binding sites in preneoplastic and neoplastic lesions of human and rodent respiratory tracts. J Natl Cancer Inst. 1984 Jan; 72(1):43-51. PMID: 6198550.

Citations:
Terzaghi M, Klein-Szanto A, Nettesheim P. Effect of the promoter 12-O-tetradecanoylphorbol-13-acetate on the evolution of carcinogen-altered cell populations in tracheas initiated with 7,12-dimethylbenz(a)anthracene. Cancer Res. 1983 Apr; 43(4):1461-6. PMID: 6403223.

Citations:
Klein-Szanto AJ, Nelson KG, Shah Y, Slaga TJ. Simultaneous appearance of keratin modifications and gamma-glutamyltransferase activity as indicators of tumor progression in mouse skin papillomas. J Natl Cancer Inst. 1983 Jan; 70(1):161-8. PMID: 6185712.

Citations:
Shiba M, Klein-Szanto AJ. Variation of gamma glutamyl transpeptidase activity and lectin binding in the course of carcinogenesis of the respiratory tract epithelium. Carcinogenesis. 1983; 4(6):687-91. PMID: 6134592.

Citations:
Slaga TJ, Klein-Szanto AJ. Initiation-promotion versus complete skin carcinogenesis in mice: importance of dark basal keratinocytes (stem cells). Cancer Invest. 1983; 1(5):425-36. PMID: 6365275.

Citations:
Haschek WM, Reiser KM, Klein-Szanto AJ, Kehrer JP, Smith LH, Last JA, Witschi HP. Potentiation of butylated hydroxytoluene-induced acute lung damage by oxygen. Cell kinetics and collagen metabolism. Am Rev Respir Dis. 1983 Jan; 127(1):28-34. PMID: 6849545.

Citations:
Shiba M, Klein-Szanto AJ, Marchok AC, Pal BC, Nettesheim P. Effect of carcinogen release rate on the incidence of preneoplastic and neoplastic lesions of the respiratory tract epithelium in rats. J Natl Cancer Inst. 1982 Nov; 69(5):1155-61. PMID: 6813552.

Citations:
Klein-Szanto AJ, Terzaghi M, Mirkin LD, Martin D, Shiba M. Propagation of normal human epithelial cell populations using an in vivo culture system. Description and applications. Am J Pathol. 1982 Aug; 108(2):231-9. PMID: 6821529.

Citations:
Klein-Szanto AJ, Nettesheim P, Saccomanno G. Dark epithelial cells in preneoplastic lesions of the human respiratory tract. Cancer. 1982 Jul 01; 50(1):107-13. PMID: 7083115.

Citations:
Bourin MC, Delescluse C, F?rstenberger G, Marks F, Schweizer J, Klein-Szanto AJ, Prunieras M. Effect of phorbol esters on guniea pig skin in vivo. Carcinogenesis. 1982; 3(6):671-6. PMID: 7116561.

Citations:
Slaga TJ, Fischer SM, Weeks CE, Klein-Szanto AJ, Reiners J. Studies on the mechanisms involved in multistage carcinogenesis in mouse skin. J Cell Biochem. 1982; 18(1):99-119. PMID: 7040428.

Citations:
Klein-Szanto AJ, Major SK, Slaga TJ. Quantitative evaluation of dark keratinocytes induced by several promoting and hyperplasiogenic agents: their use as an early morphological indicator of tumor-promoting action. Carcinog Compr Surv. 1982; 7:305-9. PMID: 6175412.

Citations:
Slaga TJ, Fischer SM, Weeks CE, Nelson K, Mamrack M, Klein-Szanto AJ. Specificity and mechanism(s) of promoter inhibitors in multistage promotion. Carcinog Compr Surv. 1982; 7:19-34. PMID: 7039828.

Citations:
Klein-Szanto AJ, Martin D, Sega M. Hyperkeratinization and hyperplasia of the forestomach epithelium in vitamin A deficient rats. Virchows Arch B Cell Pathol Incl Mol Pathol. 1982; 40(3):387-94. PMID: 6184878.

Citations:
Haschek WM, Brody AR, Klein-Szanto AJ, Witschi H. Animal model of human disease. Diffuse interstitial pulmonary fibrosis. Pulmonary fibrosis in mice induced by treatment with butylated hydroxytoluene and oxygen. Am J Pathol. 1981 Dec; 105(3):333-5. PMID: 7315951.

Citations:
Klein-Szanto AJ, Slaga TJ. Numerical variation of dark cells in normal and chemically induced hyperplastic epidermis with age of animal and efficiency of tumor promoter. Cancer Res. 1981 Nov; 41(11 Pt 1):4437-40. PMID: 6796260.

Citations:
Slaga TJ, Klein-Szanto AJ, Triplett LL, Yotti LP, Trosko KE. Skin tumor-promoting activity of benzoyl peroxide, a widely used free radical-generating compound. Science. 1981 Aug 28; 213(4511):1023-5. PMID: 6791284.

Citations:
Marchok AC, Clark JN, Klein-Szanto A. Modulation of growth, differentiation, and mucous glycoprotein synthesis by retinyl acetate in cloned carcinoma cell lines. J Natl Cancer Inst. 1981 Jun; 66(6):1165-74. PMID: 6941046.

Citations:
Klein-Szanto AJ, Nettesheim P, Pine A, Martin D. Distribution and ultrastructural characteristics of dark cells in squamous metaplasias of the respiratory tract epithelium. Am J Pathol. 1981 May; 103(2):263-70. PMID: 6786102.

Citations:
Marchok AC, Clark JN, Klein-Szanto A. Modulation of differentiation and mucous glycoprotein synthesis in cloned tracheal epithelial tumor cells exposed to retinyl acetate in vitro. Ann N Y Acad Sci. 1981 Feb 27; 359:410-1. PMID: 6942691.

Citations:
Nettesheim P, Klein-Szanto AJ, Marchok AC, Steele VE, Terzaghi M, Topping DC. Studies of neoplastic development in respiratory tract epithelium. Arch Pathol Lab Med. 1981 Jan; 105(1):1-10. PMID: 6779777.

Citations:
Witschi HR, Haschek WM, Klein-Szanto AJ, Hakkinen PJ. Potentiation of diffuse lung damage by oxygen: determining variables. Am Rev Respir Dis. 1981 Jan; 123(1):98-103. PMID: 7458090.

Citations:
Terzaghi M, Klein-Szanto AJ. Differentiation of normal and cultured preneoplastic tracheal epithelial cells in rats: importance of epithelial mesenchymal interactions. J Natl Cancer Inst. 1980 Nov; 65(5):1039-48. PMID: 6776326.

Citations:
Klein-Szanto AJ, Major SK, Slaga TJ. Induction of dark keratinocytes by 12-O-tetradecanoylphorbol-13-acetate and mezerein as an indicator of tumor-promoting efficiency. Carcinogenesis. 1980 May; 1(5):399-406. PMID: 6168406.

Citations:
Slaga TJ, Klein-Szanto AJ, Fischer SM, Weeks CE, Nelson K, Major S. Studies on mechanism of action of anti-tumor-promoting agents: their specificity in two-stage promotion. Proc Natl Acad Sci U S A. 1980 Apr; 77(4):2251-4. PMID: 6769125.

Citations:
Slaga TJ, Fischer SM, Weeks CE, Klein-Szanto AJ. Multistage chemical carcinogenesis in mouse skin. Curr Probl Dermatol. 1980; 10:193-218. PMID: 6786833.

Citations:
Klein-Szanto AJ, Topping DC, Heckman CA, Nettesheim P. Ultrastructural characteristics of carcinogen-induced nondysplastic changes in tracheal epithelium. Am J Pathol. 1980 Jan; 98(1):61-82. PMID: 6766047.

Citations:
Klein-Szanto AJ, Clark JN, Martin DH. Sexual differences in the distribution of epithelial alterations in vitamin A-deficient rats. Int J Vitam Nutr Res. 1980; 50(1):61-9. PMID: 7390717.

Citations:
Klein-Szanto AJ, Nettesheim P, Topping DC, Olson AC. Quantitative analysis of disturbed cell maturation in dysplastic lesions of the respiratory tract epithelium. Carcinogenesis. 1980; 1(12):1007-16. PMID: 11272105.

Citations:
Klein-Szanto AJ, Topping DC, Heckman CA, Nettesheim P. Ultrastructural characteristics of carcinogen-induced dysplastic changes in tracheal epithelium. Am J Pathol. 1980 Jan; 98(1):83-100. PMID: 6766048.

Citations:
Klein-Szanto AJ, Schroeder HE. Architecture and density of the connective tissue papillae of the human oral mucosa. J Anat. 1977 Feb; 123(Pt 1):93-109. PMID: 838625.

Citations:
Klein-Szanto AJ, Andersen L, Schroeder HE. Epithelial differentiation patterns in buccal mucosa affected by lichen planus. Virchows Arch B Cell Pathol. 1976 Nov 24; 22(3):245-61. PMID: 827105.

Citations:
Klein-Szanto AJ, B?n?czy J, Schroeder HE. Metaplastic conversion of the differentiation pattern in oral epithelia affected by leukoplakia simplex. A stereologic study. Pathol Eur. 1976; 11(3):189-210. PMID: 980544.

Citations:
Klein-Szanto AJ, de Rey BL, Conti CJ, Cabrini RL. Ultrastructure of irradiated nuclei. Strahlentherapie. 1974 Mar; 147(3):263-70. PMID: 4844433.

Citations:
Klein-Szanto AJ, Conti CJ, Cartagenova RE. Ultrastructure of a vaginal myxoma of a rat. Vet Pathol. 1974; 11(4):289-96. PMID: 4376634.

Citations:
Conti CJ, Klein-Szanto AJ, Moreira JL. Effects of radiation on cultured BHK cells and their latent "R" particles. An electron microscope study. Arch Geschwulstforsch. 1974; 43(3):254-67. PMID: 4851773.

Citations:
Klein-Szanto AJ, Conti CJ, Mayo J. Ultramorphological features of an experimental hamster sarcoma. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1973 Dec 28; 80(4):277-84. PMID: 4273886.

Citations:
Mayo J, Lombardo L, Klein-Szanto AJ, Conti CJ, Moreira JL. An oncogenic virus carried by hamster kidney cells. Cancer Res. 1973 Oct; 33(10):2273-7. PMID: 4741929.

Citations:
Conti CJ, Klein-Szanto AJ. Nuclear multivesicular bodies in cultured hamster cells. Experientia. 1973; 29(7):850-1. PMID: 4724723.

Citations:

Year	Publications
1996	7
1997	9
1998	10
1999	11
2000	8
2001	7
2002	7
2003	8
2004	9
2005	13
2006	14
2007	16
2008	9
2009	10
2010	22
2011	10
2012	11
2013	10
2014	6
2015	7
2016	8
2017	6
2018	10
2019	7
2020	4
2021	5
2022	4
2023	7
2024	9
2025	2

Klein-Szanto's Networks

Click the

Explore

buttons for more information and interactive visualizations!

Concepts (1333)

Explore

Co-Authors (17)

Explore

Similar People (59)

Explore

Same Department

Explore

The Thomas Jefferson University web site, its contents and programs, is provided for informational and educational purposes only and is not intended as medical advice nor is it intended to create any physician-patient relationship. Please remember that this information should not substitute for a visit or a consultation with a health care provider. The views or opinions expressed in the resources provided do not necessarily reflect those of Thomas Jefferson University, Thomas Jefferson University Hospital, or the Jefferson Health System or staff.
Please read our Privacy Statement