Thomas Jefferson University

Richard Hardy

TitleVolunteer Faculty
InstitutionThomas Jefferson University
DepartmentFaculty Records and Publicatio - Thomas Jefferson University
Address833 Chestnut Street
Philadelphia PA 19023
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    R01AI026782     (HARDY, RICHARD R)Dec 1, 1989 - Jan 31, 2013
    NIH
    LY-1 B Cells: Developmental Origins and V Gene Biases
    Role: Principal Investigator
    R56AI026782     (HARDY, RICHARD R)Dec 1, 1989 - May 31, 2014
    NIH
    Ly-1 B Cells: Developmental Origins and V Gene Biases
    Role: Principal Investigator
    S10RR010420     (HARDY, RICHARD R)Jun 1, 1995 - May 31, 1996
    NIH
    AUTOMATED DNA SEQUENCER
    Role: Principal Investigator
    R01AI040946     (HARDY, RICHARD R)Apr 1, 1997 - Mar 31, 2009
    NIH
    Immunoglobulin V Genes and B Cell Development
    Role: Principal Investigator
    S10RR016953     (HARDY, RICHARD R)May 1, 2002 - Apr 30, 2003
    NIH
    BD Biosciences LSR Flow Cytometer
    Role: Principal Investigator
    RC1CA145445     (HARDY, RICHARD R)Sep 30, 2009 - Sep 29, 2011
    NIH
    Pre-BCR Function Selecting Novel B Cell Receptors in Chronic Lymphocytic Leukemia
    Role: Principal Investigator
    R21AI117429     (HAYAKAWA, KYOKO)Jan 5, 2015 - Dec 31, 2017
    NIH
    Generation and characterization of human B1 B cells induced by Lin28b reprogramming of adult hematopoietic progenitors
    Role: Co-Principal Investigator
    R01AI113320     (HAYAKAWA, KYOKO)Jul 15, 2015 - Dec 31, 2020
    NIH
    Mechanisms regulating the B lymphopoiesis fetal/adult switch
    Role: Co-Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hayakawa K, Li YS, Shinton SA, Bandi SR, Formica AM, Brill-Dashoff J, Hardy RR. Crucial Role of Increased Arid3a at the Pre-B and Immature B Cell Stages for B1a Cell Generation. Front Immunol. 2019; 10:457. PMID: 30930899.
      Citations:    
    2. Hayakawa K, Formica AM, Nakao Y, Ichikawa D, Shinton SA, Brill-Dashoff J, Smith MR, Morse HC, Hardy RR. Early Generated B-1-Derived B Cells Have the Capacity To Progress To Become Mantle Cell Lymphoma-like Neoplasia in Aged Mice. J Immunol. 2018 07 15; 201(2):804-813. PMID: 29898964.
      Citations:    
    3. Hayakawa K, Formica AM, Zhou Y, Ichikawa D, Asano M, Li YS, Shinton SA, Brill-Dashoff J, N??ez G, Hardy RR. NLR Nod1 signaling promotes survival of BCR-engaged mature B cells through up-regulated Nod1 as a positive outcome. J Exp Med. 2017 Oct 02; 214(10):3067-3083. PMID: 28878001.
      Citations:    
    4. Liu X, Li YS, Shinton SA, Rhodes J, Tang L, Feng H, Jette CA, Look AT, Hayakawa K, Hardy RR. Zebrafish B Cell Development without a Pre-B Cell Stage, Revealed by CD79 Fluorescence Reporter Transgenes. J Immunol. 2017 09 01; 199(5):1706-1715. PMID: 28739882.
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    5. Hayakawa K, Formica AM, Brill-Dashoff J, Shinton SA, Ichikawa D, Zhou Y, Morse HC, Hardy RR. Early generated B1 B cells with restricted BCRs become chronic lymphocytic leukemia with continued c-Myc and low Bmf expression. J Exp Med. 2016 12 12; 213(13):3007-3024. PMID: 27899442.
      Citations:    
    6. Hardy RR, Hayakawa K. Selection of natural autoreactive B cells. Clin Exp Rheumatol. 2015 Jul-Aug; 33(4 Suppl 92):S80-6. PMID: 26457505.
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    7. Seiler C, Gebhart N, Zhang Y, Shinton SA, Li YS, Ross NL, Liu X, Li Q, Bilbee AN, Varshney GK, LaFave MC, Burgess SM, Balciuniene J, Balciunas D, Hardy RR, Kappes DJ, Wiest DL, Rhodes J. Mutagenesis Screen Identifies agtpbp1 and eps15L1 as Essential for T lymphocyte Development in Zebrafish. PLoS One. 2015; 10(7):e0131908. PMID: 26161877.
      Citations:    
    8. Li YS, Zhou Y, Tang L, Shinton SA, Hayakawa K, Hardy RR. A developmental switch between fetal and adult B lymphopoiesis. Ann N Y Acad Sci. 2015 Dec; 1362:8-15. PMID: 25931205.
      Citations:    
    9. Hayakawa K, Formica AM, Colombo MJ, Ichikawa D, Shinton SA, Brill-Dashoff J, Hardy RR. B cells generated by B-1 development can progress to chronic lymphocytic leukemia. Ann N Y Acad Sci. 2015 Dec; 1362:250-5. PMID: 25907284.
      Citations:    
    10. Zhou Y, Li YS, Bandi SR, Tang L, Shinton SA, Hayakawa K, Hardy RR. Lin28b promotes fetal B lymphopoiesis through the transcription factor Arid3a. J Exp Med. 2015 Apr 06; 212(4):569-80. PMID: 25753579.
      Citations:    
    11. Ichikawa D, Asano M, Shinton SA, Brill-Dashoff J, Formica AM, Velcich A, Hardy RR, Hayakawa K. Natural anti-intestinal goblet cell autoantibody production from marginal zone B cells. J Immunol. 2015 Jan 15; 194(2):606-14. PMID: 25480561.
      Citations:    
    12. Shukla V, Ma S, Hardy RR, Joshi SS, Lu R. A role for IRF4 in the development of CLL. Blood. 2013 Oct 17; 122(16):2848-55. PMID: 23926303.
      Citations:    
    13. Mingueneau M, Kreslavsky T, Gray D, Heng T, Cruse R, Ericson J, Bendall S, Spitzer MH, Nolan GP, Kobayashi K, von Boehmer H, Mathis D, Benoist C, Best AJ, Knell J, Goldrath A, Joic V, Koller D, Shay T, Regev A, Cohen N, Brennan P, Brenner M, Kim F, Nageswara Rao T, Wagers A, Heng T, Ericson J, Rothamel K, Ortiz-Lopez A, Mathis D, Benoist C, Bezman NA, Sun JC, Min-Oo G, Kim CC, Lanier LL, Miller J, Brown B, Merad M, Gautier EL, Jakubzick C, Randolph GJ, Monach P, Blair DA, Dustin ML, Shinton SA, Hardy RR, Laidlaw D, Collins J, Gazit R, Rossi DJ, Malhotra N, Sylvia K, Kang J, Kreslavsky T, Fletcher A, Elpek K, Bellemare-Pelletier A, Malhotra D, Turley S. The transcriptional landscape of a? T cell differentiation. Nat Immunol. 2013 Jun; 14(6):619-32. PMID: 23644507.
      Citations:    
    14. Jojic V, Shay T, Sylvia K, Zuk O, Sun X, Kang J, Regev A, Koller D, Best AJ, Knell J, Goldrath A, Joic V, Koller D, Shay T, Regev A, Cohen N, Brennan P, Brenner M, Kim F, Rao TN, Wagers A, Heng T, Ericson J, Rothamel K, Ortiz-Lopez A, Mathis D, Benoist C, Bezman NA, Sun JC, Min-Oo G, Kim CC, Lanier LL, Miller J, Brown B, Merad M, Gautier EL, Jakubzick C, Randolph GJ, Monach P, Blair DA, Dustin ML, Shinton SA, Hardy RR, Laidlaw D, Collins J, Gazit R, Rossi DJ, Malhotra N, Sylvia K, Kang J, Kreslavsky T, Fletcher A, Elpek K, Bellemarte-Pelletier A, Malhotra D, Turley S. Identification of transcriptional regulators in the mouse immune system. Nat Immunol. 2013 Jun; 14(6):633-43. PMID: 23624555.
      Citations:    
    15. Hardy RR, Carmack CE, Shinton SA, Kemp JD, Hayakawa K. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. 1991. J Immunol. 2012 Oct 01; 189(7):3271-83. PMID: 22997230.
      Citations:    
    16. Cooper CL, Hardy RR, Reth M, Desiderio S. Non-cell-autonomous hedgehog signaling promotes murine B lymphopoiesis from hematopoietic progenitors. Blood. 2012 Jun 07; 119(23):5438-48. PMID: 22517907.
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    17. Hardy RR, Hayakawa K. Positive and negative selection of natural autoreactive B cells. Adv Exp Med Biol. 2012; 750:227-38. PMID: 22903678.
      Citations:    
    18. Painter MW, Davis S, Hardy RR, Mathis D, Benoist C. Transcriptomes of the B and T lineages compared by multiplatform microarray profiling. J Immunol. 2011 Mar 01; 186(5):3047-57. PMID: 21307297.
      Citations:    
    19. Izumchenko E, Singh MK, Plotnikova OV, Tikhmyanova N, Little JL, Serebriiskii IG, Seo S, Kurokawa M, Egleston BL, Klein-Szanto A, Pugacheva EN, Hardy RR, Wolfson M, Connolly DC, Golemis EA. NEDD9 promotes oncogenic signaling in mammary tumor development. Cancer Res. 2009 Sep 15; 69(18):7198-206. PMID: 19738060.
      Citations:    
    20. Kadariya Y, Yin B, Tang B, Shinton SA, Quinlivan EP, Hua X, Klein-Szanto A, Al-Saleem TI, Bassing CH, Hardy RR, Kruger WD. Mice heterozygous for germ-line mutations in methylthioadenosine phosphorylase (MTAP) die prematurely of T-cell lymphoma. Cancer Res. 2009 Jul 15; 69(14):5961-9. PMID: 19567676.
      Citations:    
    21. Zhang H, Rosenberg S, Coffey FJ, He YW, Manser T, Hardy RR, Zhang J. A role for cFLIP in B cell proliferation and stress MAPK regulation. J Immunol. 2009 Jan 01; 182(1):207-15. PMID: 19109151.
      Citations:    
    22. Amin RH, Cado D, Nolla H, Huang D, Shinton SA, Zhou Y, Hardy RR, Schlissel MS. Biallelic, ubiquitous transcription from the distal germline Ig{kappa} locus promoter during B cell development. Proc Natl Acad Sci U S A. 2009 Jan 13; 106(2):522-7. PMID: 19116268.
      Citations:    
    23. Schram BR, Tze LE, Ramsey LB, Liu J, Najera L, Vegoe AL, Hardy RR, Hippen KL, Farrar MA, Behrens TW. B cell receptor basal signaling regulates antigen-induced Ig light chain rearrangements. J Immunol. 2008 Apr 01; 180(7):4728-41. PMID: 18354197.
      Citations:    
    24. Rowley B, Tang L, Shinton S, Hayakawa K, Hardy RR. Autoreactive B-1 B cells: constraints on natural autoantibody B cell antigen receptors. J Autoimmun. 2007 Dec; 29(4):236-45. PMID: 17889506.
      Citations:    
    25. Anderson SJ, Lauritsen JP, Hartman MG, Foushee AM, Lefebvre JM, Shinton SA, Gerhardt B, Hardy RR, Oravecz T, Wiest DL. Ablation of ribosomal protein L22 selectively impairs alphabeta T cell development by activation of a p53-dependent checkpoint. Immunity. 2007 Jun; 26(6):759-72. PMID: 17555992.
      Citations:    
    26. Hardy RR, Kincade PW, Dorshkind K. The protean nature of cells in the B lymphocyte lineage. Immunity. 2007 Jun; 26(6):703-14. PMID: 17582343.
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    27. Kitaura Y, Jang IK, Wang Y, Han YC, Inazu T, Cadera EJ, Schlissel M, Hardy RR, Gu H. Control of the B cell-intrinsic tolerance programs by ubiquitin ligases Cbl and Cbl-b. Immunity. 2007 May; 26(5):567-78. PMID: 17493844.
      Citations:    
    28. Hardy RR. B-1 B cell development. J Immunol. 2006 Sep 01; 177(5):2749-54. PMID: 16920907.
      Citations:    
    29. Hardy RR. B-1 B cells: development, selection, natural autoantibody and leukemia. Curr Opin Immunol. 2006 Oct; 18(5):547-55. PMID: 16879952.
      Citations:    
    30. Rumfelt LL, Zhou Y, Rowley BM, Shinton SA, Hardy RR. Lineage specification and plasticity in CD19- early B cell precursors. J Exp Med. 2006 Mar 20; 203(3):675-87. PMID: 16505143.
      Citations:    
    31. Wen L, Brill-Dashoff J, Shinton SA, Asano M, Hardy RR, Hayakawa K. Evidence of marginal-zone B cell-positive selection in spleen. Immunity. 2005 Sep; 23(3):297-308. PMID: 16169502.
      Citations:    
    32. Butcher EC, Rouse RV, Coffman RL, Nottenburg CN, Hardy RR, Weissman IL. Surface phenotype of Peyer's patch germinal center cells: implications for the role of germinal centers in B cell differentiation. 1982. J Immunol. 2005 Aug 01; 175(3):1363-72. PMID: 16034071.
      Citations:    
    33. Wen L, Shinton SA, Hardy RR, Hayakawa K. Association of B-1 B cells with follicular dendritic cells in spleen. J Immunol. 2005 Jun 01; 174(11):6918-26. PMID: 15905534.
      Citations:    
    34. Tze LE, Schram BR, Lam KP, Hogquist KA, Hippen KL, Liu J, Shinton SA, Otipoby KL, Rodine PR, Vegoe AL, Kraus M, Hardy RR, Schlissel MS, Rajewsky K, Behrens TW. Basal immunoglobulin signaling actively maintains developmental stage in immature B cells. PLoS Biol. 2005 Mar; 3(3):e82. PMID: 15752064.
      Citations:    
    35. Maier H, Ostraat R, Gao H, Fields S, Shinton SA, Medina KL, Ikawa T, Murre C, Singh H, Hardy RR, Hagman J. Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription. Nat Immunol. 2004 Oct; 5(10):1069-77. PMID: 15361869.
      Citations:    
    36. Hardy RR, Wei CJ, Hayakawa K. Selection during development of VH11+ B cells: a model for natural autoantibody-producing CD5+ B cells. Immunol Rev. 2004 Feb; 197:60-74. PMID: 14962187.
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    37. Hardy RR, Shinton SA. Characterization of B lymphopoiesis in mouse bone marrow and spleen. Methods Mol Biol. 2004; 271:1-24. PMID: 15146109.
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    38. Hardy RR. B-cell commitment: deciding on the players. Curr Opin Immunol. 2003 Apr; 15(2):158-65. PMID: 12633665.
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    39. Hayakawa K, Asano M, Shinton SA, Gui M, Wen LJ, Dashoff J, Hardy RR. Positive selection of anti-thy-1 autoreactive B-1 cells and natural serum autoantibody production independent from bone marrow B cell development. J Exp Med. 2003 Jan 06; 197(1):87-99. PMID: 12515816.
      Citations:    
    40. Hardy RR. Development of VH11+ B cells: a model for selection of B cells producing natural autoantibodies. Curr Dir Autoimmun. 2003; 6:196-211. PMID: 12408053.
      Citations:    
    41. Bichi R, Shinton SA, Martin ES, Koval A, Calin GA, Cesari R, Russo G, Hardy RR, Croce CM. Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression. Proc Natl Acad Sci U S A. 2002 May 14; 99(10):6955-60. PMID: 12011454.
      Citations:    
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