Thomas Jefferson University

Patrick Most

TitleVolunteer Faculty
InstitutionThomas Jefferson University
DepartmentFaculty Records and Publicatio - Thomas Jefferson University
Address1025 Walnut Street
Philadelphia PA 19107
Phone215-955-8990
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ritterhoff J, McMillen T, Foundas H, Palkovacs R, Poschet G, Caudal A, Liu Y, Most P, Walker M, Tian R. 13C stable isotope tracing reveals distinct fatty acid oxidation pathways in proliferative versus oxidative cells. Am J Physiol Cell Physiol. 2025 01 01; 328(1):C168-C178. PMID: 39611618.
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    2. Van Linthout S, Stellos K, Giacca M, Bertero E, Cannata A, Carrier L, Garcia-Pavia P, Ghigo A, Gonz?lez A, Haugaa KH, Imazio M, Lopes LR, Most P, Pollesello P, Schunkert H, Streckfuss-B?meke K, Thum T, Tocchetti CG, Tsch?pe C, van der Meer P, van Rooij E, Metra M, Rosano GMC, Heymans S. State of the art and perspectives of gene therapy in heart failure. A scientific statement of the Heart Failure Association of the ESC, the ESC Council on Cardiovascular Genomics and the ESC Working Group on Myocardial & Pericardial Diseases. Eur J Heart Fail. 2025 01; 27(1):5-25. PMID: 39576264.
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    3. Kehr D, Ritterhoff J, Glaser M, Jarosch L, Salazar RE, Spaich K, Varadi K, Birkenstock J, Egger M, Gao E, Koch WJ, Sauter M, Freichel M, Katus HA, Frey N, Jungmann A, Busch C, Mather PJ, Ruhparwar A, Busch M, V?lkers M, Wade RC, Most P. S100A1ct: A Synthetic Peptide Derived From S100A1 Protein Improves Cardiac Performance and Survival in Preclinical Heart Failure Models. Circulation. 2025 Feb 25; 151(8):548-565. PMID: 39569500.
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    4. Lerchenm?ller C, Hastings MH, Rabolli CP, Betge F, Roshan M, Liu LX, Liu X, He? C, Roh JD, Platt C, Bezzerides V, Busch M, Katus HA, Frey N, Most P, Rosenzweig A. CITED4 gene therapy protects against maladaptive cardiac remodeling after ischemia/reperfusion injury in mice. Mol Ther. 2024 10 02; 32(10):3683-3694. PMID: 39066479.
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    5. Schweiggert F, Habeck G, Most P, Busch M, Schweiggert J. ShuffleAnalyzer: A Comprehensive Tool to Visualize DNA Shuffling. ACS Synth Biol. 2024 08 16; 13(8):2625-2628. PMID: 38991172.
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    6. Seitz A, Busch M, Kroemer J, Schneider A, Simon S, Jungmann A, Katus HA, Most P, Ritterhoff J. S100A1's single cysteine is an indispensable redox switch for the protection against diastolic calcium waves in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2024 07 01; 327(1):H000. PMID: 38819384.
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    7. Wingert J, Meinhardt E, Sasipong N, Pott M, Lederer C, de la Torre C, Sticht C, Most P, Katus HA, Frey N, Raake PWJ, Schlegel P. Cardiomyocyte-specific RXFP1 overexpression protects against pressure overload-induced cardiac dysfunction independently of relaxin. Biochem Pharmacol. 2024 07; 225:116305. PMID: 38768763.
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    8. Noll D, Kehr D, Most P, Ritterhoff J. S100A1: a promising therapeutic target for heart failure. Expert Opin Ther Targets. 2024 Apr; 28(4):233-236. PMID: 38641766.
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    9. Liu X, Li H, Hastings MH, Xiao C, Damilano F, Platt C, Lerchenm?ller C, Zhu H, Wei XP, Yeri A, Most P, Rosenzweig A. miR-222 inhibits pathological cardiac hypertrophy and heart failure. Cardiovasc Res. 2024 03 14; 120(3):262-272. PMID: 38084908.
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    10. Mertin V, Most P, Busch M, Trojan S, Tapking C, Haug V, Kneser U, Hundeshagen G. Current understanding of thermo(dys)regulation in severe burn injury and the pathophysiological influence of hypermetabolism, adrenergic stress and hypothalamic regulation-a systematic review. Burns Trauma. 2022; 10:tkac031. PMID: 36168403.
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    11. Haug VF, Tapking C, Panayi AC, Thiele P, Wang AT, Obed D, Hirche C, Most P, Kneser U, Hundeshagen G. Long-term sequelae of critical illness in sepsis, trauma and burns: A systematic review and meta-analysis. J Trauma Acute Care Surg. 2021 10 01; 91(4):736-747. PMID: 34252062.
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    12. Rahm AK, Wieder T, Gramlich D, M?ller ME, Wunsch MN, El Tahry FA, Heimberger T, Sandke S, Weis T, Most P, Katus HA, Thomas D, Lugenbiel P. Differential regulation of KCa 2.1 (KCNN1) K+ channel expression by histone deacetylases in atrial fibrillation with concomitant heart failure. Physiol Rep. 2021 06; 9(11):e14835. PMID: 34111326.
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    13. Rahm AK, Gramlich D, Wieder T, M?ller ME, Schoeffel A, El Tahry FA, Most P, Heimberger T, Sandke S, Weis T, Ullrich ND, Korff T, Lugenbiel P, Katus HA, Thomas D. Trigger-Specific Remodeling of KCa2 Potassium Channels in Models of Atrial Fibrillation. Pharmgenomics Pers Med. 2021; 14:579-590. PMID: 34045886.
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    14. Sasipong N, Schlegel P, Wingert J, Lederer C, Meinhardt E, Ziefer A, Schmidt C, Rapti K, Th?ni C, Frey N, Most P, Katus HA, Raake PWJ. Ligand-activated RXFP1 gene therapy ameliorates pressure overload-induced cardiac dysfunction. Mol Ther. 2021 08 04; 29(8):2499-2513. PMID: 33839322.
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    15. Ramirez Flores RO, Lanzer JD, Holland CH, Leuschner F, Most P, Schultz JH, Levinson RT, Saez-Rodriguez J. Consensus Transcriptional Landscape of Human End-Stage Heart Failure. J Am Heart Assoc. 2021 04 06; 10(7):e019667. PMID: 33787284.
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    16. Lugenbiel P, Govorov K, Syren P, Rahm AK, Wieder T, Wunsch M, Weiberg N, Manolova E, Gramlich D, Rivinius R, Finke D, Lehmann LH, Schweizer PA, Frank D, El Tahry FA, Bruehl C, Heimberger T, Sandke S, Weis T, Most P, Schmack B, Ruhparwar A, Karck M, Frey N, Katus HA, Thomas D. Epigenetic regulation of cardiac electrophysiology in atrial fibrillation: HDAC2 determines action potential duration and suppresses NRSF in cardiomyocytes. Basic Res Cardiol. 2021 02 25; 116(1):13. PMID: 33630168.
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    17. Medert R, Jungmann A, Hildebrand S, Busch M, Grimm D, Flockerzi V, M?ller OJ, Most P, Schumacher D, Freichel M. Development of an AAV9-RNAi-mediated silencing strategy to abrogate TRPM4 expression in the adult heart. Pflugers Arch. 2021 03; 473(3):533-546. PMID: 33580817.
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    18. Rahm AK, Wieder T, Gramlich D, M?ller ME, Wunsch MN, El Tahry FA, Heimberger T, Weis T, Most P, Katus HA, Thomas D, Lugenbiel P. HDAC2-dependent remodeling of KCa2.2 (KCNN2) and KCa2.3 (KCNN3) K+ channels in atrial fibrillation with concomitant heart failure. Life Sci. 2021 Feb 01; 266:118892. PMID: 33310041.
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    19. Landmesser U, Poller W, Tsimikas S, Most P, Paneni F, L?scher TF. From traditional pharmacological towards nucleic acid-based therapies for cardiovascular diseases. Eur Heart J. 2020 10 21; 41(40):3884-3899. PMID: 32350510.
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    20. M?ller T, Boileau E, Talyan S, Kehr D, Varadi K, Busch M, Most P, Krijgsveld J, Dieterich C. Updated and enhanced pig cardiac transcriptome based on long-read RNA sequencing and proteomics. J Mol Cell Cardiol. 2021 01; 150:23-31. PMID: 33049256.
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    21. Jakobi T, Siede D, Eschenbach J, Heum?ller AW, Busch M, Nietsch R, Meder B, Most P, Dimmeler S, Backs J, Katus HA, Dieterich C. Deep Characterization of Circular RNAs from Human Cardiovascular Cell Models and Cardiac Tissue. Cells. 2020 07 04; 9(7). PMID: 32635460.
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    22. Tapking C, Popp D, Herndon DN, Branski LK, Hundeshagen G, Armenta AM, Busch M, Most P, Kinsky MP. Cardiac Dysfunction in Severely Burned Patients: Current Understanding of Etiology, Pathophysiology, and Treatment. Shock. 2020 06; 53(6):669-678. PMID: 31626036.
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    23. Jebessa ZH, Shanmukha KD, Dewenter M, Lehmann LH, Xu C, Schreiter F, Siede D, Gong XM, Worst BC, Federico G, Sauer SW, Fischer T, Wechselberger L, M?ller OJ, Sossalla S, Dieterich C, Most P, Gr?ne HJ, Moro C, Oberer M, Haemmerle G, Katus HA, Tyedmers J, Backs J. The lipid droplet-associated protein ABHD5 protects the heart through proteolysis of HDAC4. Nat Metab. 2019 11; 1(11):1157-1167. PMID: 31742248.
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    24. Raake PWJ, Barthelmes J, Krautz B, Buss S, Huditz R, Schlegel P, Weber C, Stangassinger M, Haberkorn U, Katus HA, Most P, Pleger ST. Comprehensive cardiac phenotyping in large animals: comparison of pressure-volume analysis and cardiac magnetic resonance imaging in pig post-myocardial infarction systolic heart failure. Int J Cardiovasc Imaging. 2019 Sep; 35(9):1691-1699. PMID: 31056718.
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    25. Tscheschner H, Meinhardt E, Schlegel P, Jungmann A, Lehmann LH, M?ller OJ, Most P, Katus HA, Raake PW. CaMKII activation participates in doxorubicin cardiotoxicity and is attenuated by moderate GRP78 overexpression. PLoS One. 2019; 14(4):e0215992. PMID: 31034488.
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    26. Kmietczyk V, Riechert E, Kalinski L, Boileau E, Malovrh E, Malone B, Gorska A, Hofmann C, Varma E, J?rgensen L, Kamuf-Schenk V, Altm?ller J, Tappu R, Busch M, Most P, Katus HA, Dieterich C, V?lkers M. m6A-mRNA methylation regulates cardiac gene expression and cellular growth. Life Sci Alliance. 2019 04; 2(2). PMID: 30967445.
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    27. Klett H, J?rgensen L, Most P, Busch M, G?nther F, Dobreva G, Leuschner F, Hassel D, Busch H, Boerries M. Delineating the Dynamic Transcriptome Response of mRNA and microRNA during Zebrafish Heart Regeneration. Biomolecules. 2018 12 28; 9(1). PMID: 30597924.
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    28. Bauer R, Enns H, Jungmann A, Leuchs B, Volz C, Schinkel S, Koch WJ, Raake PW, Most P, Katus HA, M?ller OJ. Various effects of AAV9-mediated ?ARKct gene therapy on the heart in dystrophin-deficient (mdx) mice and d-sarcoglycan-deficient (Sgcd-/-) mice. Neuromuscul Disord. 2019 03; 29(3):231-241. PMID: 30782477.
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    29. Korkmaz-Ic?z S, Li S, Loganathan S, Radovits T, Ruppert M, Brlecic P, Sayour AA, Veres G, Fleming T, Brune M, Most P, Karck M, Szab? G. Impairment of the Akt pathway in transplanted Type 1 diabetic hearts is associated with post-transplant graft injury. Interact Cardiovasc Thorac Surg. 2018 12 01; 27(6):884-894. PMID: 29912386.
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    30. El-Battrawy I, Zhao Z, Lan H, Li X, Y?cel G, Lang S, Sattler K, Sch?nemann JD, Zimmermann WH, Cyganek L, Utikal J, Wieland T, Bieback K, Bauer R, Ratte A, Pribe-Wolferts R, Rapti K, Nowak D, Wittig J, Thomas D, Most P, Katus HA, Ravens U, Schmidt C, Borggrefe M, Zhou XB, M?ller OJ, Akin I. Ion Channel Dysfunctions in Dilated Cardiomyopathy in Limb-Girdle Muscular Dystrophy. Circ Genom Precis Med. 2018 03; 11(3):e001893. PMID: 29545480.
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    31. Jungi S, Fu X, Segiser A, Busch M, Most P, Fiedler M, Carrel T, Tevaearai Stahel H, Longnus SL, Most H. Enhanced Cardiac S100A1 Expression Improves Recovery from Global Ischemia-Reperfusion Injury. J Cardiovasc Transl Res. 2018 06; 11(3):236-245. PMID: 29392537.
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    32. Lehmann LH, Jebessa ZH, Kreusser MM, Horsch A, He T, Kronlage M, Dewenter M, Sramek V, Oehl U, Krebs-Haupenthal J, von der Lieth AH, Schmidt A, Sun Q, Ritterhoff J, Finke D, V?lkers M, Jungmann A, Sauer SW, Thiel C, Nickel A, Kohlhaas M, Sch?fer M, Sticht C, Maack C, Gretz N, Wagner M, El-Armouche A, Maier LS, Londo?o JEC, Meder B, Freichel M, Gr?ne HJ, Most P, M?ller OJ, Herzig S, Furlong EEM, Katus HA, Backs J. A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway. Nat Med. 2018 01; 24(1):62-72. PMID: 29227474.
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    33. M?ller I, Vogl T, Pappritz K, Miteva K, Savvatis K, Rohde D, Most P, Lassner D, Pieske B, K?hl U, Van Linthout S, Tsch?pe C. Pathogenic Role of the Damage-Associated Molecular Patterns S100A8 and S100A9 in Coxsackievirus B3-Induced Myocarditis. Circ Heart Fail. 2017 Nov; 10(11). PMID: 29158436.
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    34. Schlegel P, Reinkober J, Meinhardt E, Tscheschner H, Gao E, Schumacher SM, Yuan A, Backs J, Most P, Wieland T, Koch WJ, Katus HA, Raake PW. G protein-coupled receptor kinase 2 promotes cardiac hypertrophy. PLoS One. 2017; 12(7):e0182110. PMID: 28759639.
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    35. Kossack M, Hein S, Juergensen L, Siragusa M, Benz A, Katus HA, Most P, Hassel D. Induction of cardiac dysfunction in developing and adult zebrafish by chronic isoproterenol stimulation. J Mol Cell Cardiol. 2017 07; 108:95-105. PMID: 28554511.
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    36. Lerchenm?ller C, Hei?enberg J, Damilano F, Bezzeridis VJ, Kr?mer I, Bochaton-Piallat ML, Hirschberg K, Busch M, Katus HA, Peppel K, Rosenzweig A, Busch H, Boerries M, Most P. S100A6 Regulates Endothelial Cell Cycle Progression by Attenuating Antiproliferative Signal Transducers and Activators of Transcription 1 Signaling. Arterioscler Thromb Vasc Biol. 2016 09; 36(9):1854-67. PMID: 27386938.
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    37. Eden M, Meder B, V?lkers M, Poomvanicha M, Domes K, Branchereau M, Marck P, Will R, Bernt A, Rangrez A, Busch M, Hrabe de Angelis M, Heymes C, Rottbauer W, Most P, Hofmann F, Frey N. Erratum: Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression. Nat Commun. 2016 05 26; 7:11835. PMID: 27225593.
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    38. Rebbeck RT, Nitu FR, Rohde D, Most P, Bers DM, Thomas DD, Cornea RL. S100A1 Protein Does Not Compete with Calmodulin for Ryanodine Receptor Binding but Structurally Alters the Ryanodine Receptor?Calmodulin Complex. J Biol Chem. 2016 07 22; 291(30):15896-907. PMID: 27226555.
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    39. Korkmaz-Ic?z S, Al Said S, Radovits T, Li S, Brune M, Hegedus P, Atmanli A, Ruppert M, Brlecic P, Lehmann LH, Lahrmann B, Grabe N, Yoshikawa Y, Yasui H, Most P, Karck M, Szab? G. Oral treatment with a zinc complex of acetylsalicylic acid prevents diabetic cardiomyopathy in a rat model of type-2 diabetes: activation of the Akt pathway. Cardiovasc Diabetol. 2016 May 06; 15:75. PMID: 27153943.
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    40. Eden M, Meder B, V?lkers M, Poomvanicha M, Domes K, Branchereau M, Marck P, Will R, Bernt A, Rangrez A, Busch M, Hrabe de Angelis M, Heymes C, Rottbauer W, Most P, Hofmann F, Frey N. Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression. Nat Commun. 2016 04 28; 7:11317. PMID: 27122098.
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    41. Schlegel P, Huditz R, Meinhardt E, Rapti K, Geis N, Most P, Katus HA, M?ller OJ, Bekeredjian R, Raake PW. Locally Targeted Cardiac Gene Delivery by AAV Microbubble Destruction in a Large Animal Model. Hum Gene Ther Methods. 2016 Apr; 27(2):71-8. PMID: 26971929.
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    42. Ritterhoff J, V?lkers M, Seitz A, Spaich K, Gao E, Peppel K, Pleger ST, Zimmermann WH, Friedrich O, Fink RHA, Koch WJ, Katus HA, Most P. S100A1 DNA-based Inotropic Therapy Protects Against Proarrhythmogenic Ryanodine Receptor 2 Dysfunction. Mol Ther. 2015 Aug; 23(8):1320-1330. PMID: 26005840.
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    43. Rohde D, Busch M, Volkert A, Ritterhoff J, Katus HA, Peppel K, Most P. Cardiomyocytes, endothelial cells and cardiac fibroblasts: S100A1's triple action in cardiovascular pathophysiology. Future Cardiol. 2015 May; 11(3):309-21. PMID: 26021637.
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    44. Buss SJ, Krautz B, Hofmann N, Sander Y, Rust L, Giusca S, Galuschky C, Seitz S, Giannitsis E, Pleger S, Raake P, Most P, Katus HA, Korosoglou G. Prediction of functional recovery by cardiac magnetic resonance feature tracking imaging in first time ST-elevation myocardial infarction. Comparison to infarct size and transmurality by late gadolinium enhancement. Int J Cardiol. 2015 Mar 15; 183:162-70. PMID: 25675901.
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    45. Friedrich O, Yi B, Edwards JN, Reischl B, Wirth-H?cking A, Buttgereit A, Lang R, Weber C, Polyak F, Liu I, von Wegner F, Cully TR, Lee A, Most P, V?lkers M. IL-1a reversibly inhibits skeletal muscle ryanodine receptor. a novel mechanism for critical illness myopathy? Am J Respir Cell Mol Biol. 2014 Jun; 50(6):1096-106. PMID: 24400695.
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    46. Rohde D, Sch?n C, Boerries M, Didrihsone I, Ritterhoff J, Kubatzky KF, V?lkers M, Herzog N, M?hler M, Tsoporis JN, Parker TG, Linke B, Giannitsis E, Gao E, Peppel K, Katus HA, Most P. S100A1 is released from ischemic cardiomyocytes and signals myocardial damage via Toll-like receptor 4. EMBO Mol Med. 2014 Jun; 6(6):778-94. PMID: 24833748.
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    47. Sen A, Most P, Peppel K. Induction of microRNA-138 by pro-inflammatory cytokines causes endothelial cell dysfunction. FEBS Lett. 2014 Mar 18; 588(6):906-14. PMID: 24486907.
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    48. Pleger ST, Raake P, Katus HA, Most P. Cardiac calcium handling on trial: targeting the failing cardiomyocyte signalosome. Circ Res. 2014 Jan 03; 114(1):12-4. PMID: 24385502.
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    49. Weber C, Neacsu I, Krautz B, Schlegel P, Sauer S, Raake P, Ritterhoff J, Jungmann A, Remppis AB, Stangassinger M, Koch WJ, Katus HA, M?ller OJ, Most P, Pleger ST. Therapeutic safety of high myocardial expression levels of the molecular inotrope S100A1 in a preclinical heart failure model. Gene Ther. 2014 Feb; 21(2):131-8. PMID: 24305416.
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    50. Sen A, Ren S, Lerchenm?ller C, Sun J, Weiss N, Most P, Peppel K. MicroRNA-138 regulates hypoxia-induced endothelial cell dysfunction by targeting S100A1. PLoS One. 2013; 8(11):e78684. PMID: 24244340.
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    51. Brinks H, Giraud MN, Segiser A, Ferri? C, Longnus S, Ullrich ND, Koch WJ, Most P, Carrel TP, Tevaearai HT. Dynamic patterns of ventricular remodeling and apoptosis in hearts unloaded by heterotopic transplantation. J Heart Lung Transplant. 2014 Feb; 33(2):203-10. PMID: 24315785.
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    52. Pleger ST, Brinks H, Ritterhoff J, Raake P, Koch WJ, Katus HA, Most P. Heart failure gene therapy: the path to clinical practice. Circ Res. 2013 Aug 30; 113(6):792-809. PMID: 23989720.
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    53. Most P, Raake P, Weber C, Katus HA, Pleger ST. S100A1 gene therapy in small and large animals. Methods Mol Biol. 2013; 963:407-20. PMID: 23296625.
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    54. Most P, Lerchenm?ller C, Rengo G, Mahlmann A, Ritterhoff J, Rohde D, Goodman C, Busch CJ, Laube F, Heissenberg J, Pleger ST, Weiss N, Katus HA, Koch WJ, Peppel K. S100A1 deficiency impairs postischemic angiogenesis via compromised proangiogenic endothelial cell function and nitric oxide synthase regulation. Circ Res. 2013 Jan 04; 112(1):66-78. PMID: 23048072.
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    55. Raake PW, Zhang X, Vinge LE, Brinks H, Gao E, Jaleel N, Li Y, Tang M, Most P, Dorn GW, Houser SR, Katus HA, Chen X, Koch WJ. Cardiac G-protein-coupled receptor kinase 2 ablation induces a novel Ca2+ handling phenotype resistant to adverse alterations and remodeling after myocardial infarction. Circulation. 2012 May 01; 125(17):2108-18. PMID: 22496128.
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    56. Reinkober J, Tscheschner H, Pleger ST, Most P, Katus HA, Koch WJ, Raake PW. Targeting GRK2 by gene therapy for heart failure: benefits above ?-blockade. Gene Ther. 2012 Jun; 19(6):686-93. PMID: 22336718.
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    57. Ritterhoff J, Most P. Targeting S100A1 in heart failure. Gene Ther. 2012 Jun; 19(6):613-21. PMID: 22336719.
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    58. Raake PW, Schlegel P, Ksienzyk J, Reinkober J, Barthelmes J, Schinkel S, Pleger S, Mier W, Haberkorn U, Koch WJ, Katus HA, Most P, M?ller OJ. AAV6.?ARKct cardiac gene therapy ameliorates cardiac function and normalizes the catecholaminergic axis in a clinically relevant large animal heart failure model. Eur Heart J. 2013 May; 34(19):1437-47. PMID: 22261894.
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    59. V?lkers M, Dolatabadi N, Gude N, Most P, Sussman MA, Hassel D. Orai1 deficiency leads to heart failure and skeletal myopathy in zebrafish. J Cell Sci. 2012 Jan 15; 125(Pt 2):287-94. PMID: 22302996.
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    60. Raake PW, Tscheschner H, Reinkober J, Ritterhoff J, Katus HA, Koch WJ, Most P. Gene therapy targets in heart failure: the path to translation. Clin Pharmacol Ther. 2011 Oct; 90(4):542-53. PMID: 21866097.
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    61. Brinks H, Rohde D, Voelkers M, Qiu G, Pleger ST, Herzog N, Rabinowitz J, Ruhparwar A, Silvestry S, Lerchenm?ller C, Mather PJ, Eckhart AD, Katus HA, Carrel T, Koch WJ, Most P. S100A1 genetically targeted therapy reverses dysfunction of human failing cardiomyocytes. J Am Coll Cardiol. 2011 Aug 23; 58(9):966-73. PMID: 21851887.
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    62. Pleger ST, Shan C, Ksienzyk J, Bekeredjian R, Boekstegers P, Hinkel R, Schinkel S, Leuchs B, Ludwig J, Qiu G, Weber C, Raake P, Koch WJ, Katus HA, M?ller OJ, Most P. Cardiac AAV9-S100A1 gene therapy rescues post-ischemic heart failure in a preclinical large animal model. Sci Transl Med. 2011 Jul 20; 3(92):92ra64. PMID: 21775667.
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    63. Raake PW, Koch WJ, Most P. Polymorphisms present in G-protein-coupled receptor kinases and their effect on ?-blocker treatment. Pharmacogenomics. 2011 Mar; 12(3):295-7. PMID: 21449665.
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    64. V?lkers M, Weidenhammer C, Herzog N, Qiu G, Spaich K, Wegner FV, Peppel K, M?ller OJ, Schinkel S, Rabinowitz JE, Hippe HJ, Brinks H, Katus HA, Koch WJ, Eckhart AD, Friedrich O, Most P. The inotropic peptide ?ARKct improves ?AR responsiveness in normal and failing cardiomyocytes through G(??)-mediated L-type calcium current disinhibition. Circ Res. 2011 Jan 07; 108(1):27-39. PMID: 21106943.
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    65. Brinks H, Boucher M, Gao E, Chuprun JK, Pesant S, Raake PW, Huang ZM, Wang X, Qiu G, Gumpert A, Harris DM, Eckhart AD, Most P, Koch WJ. Level of G protein-coupled receptor kinase-2 determines myocardial ischemia/reperfusion injury via pro- and anti-apoptotic mechanisms. Circ Res. 2010 Oct 29; 107(9):1140-9. PMID: 20814022.
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    66. Rohde D, Brinks H, Ritterhoff J, Qui G, Ren S, Most P. S100A1 gene therapy for heart failure: a novel strategy on the verge of clinical trials. J Mol Cell Cardiol. 2011 May; 50(5):777-84. PMID: 20732326.
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    67. Rohde D, Ritterhoff J, Voelkers M, Katus HA, Parker TG, Most P. S100A1: a multifaceted therapeutic target in cardiovascular disease. J Cardiovasc Transl Res. 2010 Oct; 3(5):525-37. PMID: 20645037.
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    68. V?lkers M, Rohde D, Goodman C, Most P. S100A1: a regulator of striated muscle sarcoplasmic reticulum Ca2+ handling, sarcomeric, and mitochondrial function. J Biomed Biotechnol. 2010; 2010:178614. PMID: 20368797.
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    69. Askoxylakis V, Thieke C, Pleger ST, Most P, Tanner J, Lindel K, Katus HA, Debus J, Bischof M. Long-term survival of cancer patients compared to heart failure and stroke: a systematic review. BMC Cancer. 2010 Mar 22; 10:105. PMID: 20307299.
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    70. Voelkers M, Salz M, Herzog N, Frank D, Dolatabadi N, Frey N, Gude N, Friedrich O, Koch WJ, Katus HA, Sussman MA, Most P. Orai1 and Stim1 regulate normal and hypertrophic growth in cardiomyocytes. J Mol Cell Cardiol. 2010 Jun; 48(6):1329-34. PMID: 20138887.
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    71. Kraus C, Rohde D, Weidenhammer C, Qiu G, Pleger ST, Voelkers M, Boerries M, Remppis A, Katus HA, Most P. S100A1 in cardiovascular health and disease: closing the gap between basic science and clinical therapy. J Mol Cell Cardiol. 2009 Oct; 47(4):445-55. PMID: 19538970.
      Citations:    
    72. Luedde M, Fl?gel U, Knorr M, Grundt C, Hippe HJ, Brors B, Frank D, Haselmann U, Antony C, Voelkers M, Schrader J, Most P, Lemmer B, Katus HA, Frey N. Decreased contractility due to energy deprivation in a transgenic rat model of hypertrophic cardiomyopathy. J Mol Med (Berl). 2009 Apr; 87(4):411-22. PMID: 19189074.
      Citations:    
    73. Harris DM, Chen X, Pesant S, Cohn HI, MacDonnell SM, Boucher M, Vinge LE, Raake P, Moraca SR, Li D, Most P, Houser SR, Koch WJ, Eckhart AD. Inhibition of angiotensin II Gq signaling augments beta-adrenergic receptor mediated effects in a renal artery stenosis model of high blood pressure. J Mol Cell Cardiol. 2009 Jan; 46(1):100-7. PMID: 18930063.
      Citations:    
    74. Degeorge BR, Rosenberg M, Eckstein V, Gao E, Herzog N, Katus HA, Koch WJ, Frey N, Most P. BMP-2 and FGF-2 synergistically facilitate adoption of a cardiac phenotype in somatic bone marrow c-kit+/Sca-1+ stem cells. Clin Transl Sci. 2008 Sep; 1(2):116-25. PMID: 20443832.
      Citations:    
    75. Raake PW, Vinge LE, Gao E, Boucher M, Rengo G, Chen X, DeGeorge BR, Matkovich S, Houser SR, Most P, Eckhart AD, Dorn GW, Koch WJ. G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure. Circ Res. 2008 Aug 15; 103(4):413-22. PMID: 18635825.
      Citations:    
    76. Boucher M, Pesant S, Lei YH, Nanton N, Most P, Eckhart AD, Koch WJ, Gao E. Simultaneous administration of insulin-like growth factor-1 and darbepoetin alfa protects the rat myocardium against myocardial infarction and enhances angiogenesis. Clin Transl Sci. 2008 May; 1(1):13-20. PMID: 20443814.
      Citations:    
    77. Pleger ST, Harris DM, Shan C, Vinge LE, Chuprun JK, Berzins B, Pleger W, Druckman C, V?lkers M, Heierhorst J, ?ie E, Remppis A, Katus HA, Scalia R, Eckhart AD, Koch WJ, Most P. Endothelial S100A1 modulates vascular function via nitric oxide. Circ Res. 2008 Apr 11; 102(7):786-94. PMID: 18292599.
      Citations:    
    78. Pleger ST, Most P, Koch WJ. Recent findings into the potential of gene therapy to reverse heart failure. Expert Opin Biol Ther. 2007 Dec; 7(12):1781-4. PMID: 18034643.
      Citations:    
    79. Pleger ST, Boucher M, Most P, Koch WJ. Targeting myocardial beta-adrenergic receptor signaling and calcium cycling for heart failure gene therapy. J Card Fail. 2007 Jun; 13(5):401-14. PMID: 17602988.
      Citations:    
    80. Pleger ST, Most P, Katus HA. S100 proteins: a missing piece in the puzzle of heart failure? Cardiovasc Res. 2007 Jul 01; 75(1):1-2. PMID: 17531210.
      Citations:    
    81. Pleger ST, Most P, Boucher M, Soltys S, Chuprun JK, Pleger W, Gao E, Dasgupta A, Rengo G, Remppis A, Katus HA, Eckhart AD, Rabinowitz JE, Koch WJ. Stable myocardial-specific AAV6-S100A1 gene therapy results in chronic functional heart failure rescue. Circulation. 2007 May 15; 115(19):2506-15. PMID: 17470693.
      Citations:    
    82. Most P, Remppis A, Pleger ST, Katus HA, Koch WJ. S100A1: a novel inotropic regulator of cardiac performance. Transition from molecular physiology to pathophysiological relevance. Am J Physiol Regul Integr Comp Physiol. 2007 Aug; 293(2):R568-77. PMID: 17459908.
      Citations:    
    83. Boerries M, Most P, Gledhill JR, Walker JE, Katus HA, Koch WJ, Aebi U, Schoenenberger CA. Ca2+ -dependent interaction of S100A1 with F1-ATPase leads to an increased ATP content in cardiomyocytes. Mol Cell Biol. 2007 Jun; 27(12):4365-73. PMID: 17438143.
      Citations:    
    84. Most P, Koch WJ. S100A1: a calcium-modulating inotropic prototype for future clinical heart failure therapy. Future Cardiol. 2007 Jan; 3(1):5-11. PMID: 19804200.
      Citations:    
    85. Pleger ST, Most P, Heidt B, Voelkers M, Hata JA, Katus HA, Remppis A, Koch WJ. S100A1 gene transfer in myocardium. Eur J Med Res. 2006 Oct 27; 11(10):418-22. PMID: 17107875.
      Citations:    
    86. Most P, Seifert H, Gao E, Funakoshi H, V?lkers M, Heierhorst J, Remppis A, Pleger ST, DeGeorge BR, Eckhart AD, Feldman AM, Koch WJ. Cardiac S100A1 protein levels determine contractile performance and propensity toward heart failure after myocardial infarction. Circulation. 2006 Sep 19; 114(12):1258-68. PMID: 16952982.
      Citations:    
    87. V?lkers M, Loughrey CM, Macquaide N, Remppis A, DeGeorge BR, Wegner FV, Friedrich O, Fink RH, Koch WJ, Smith GL, Most P. S100A1 decreases calcium spark frequency and alters their spatial characteristics in permeabilized adult ventricular cardiomyocytes. Cell Calcium. 2007 Feb; 41(2):135-43. PMID: 16919727.
      Citations:    
    88. Ehlermann P, Eggers K, Bierhaus A, Most P, Weichenhan D, Greten J, Nawroth PP, Katus HA, Remppis A. Increased proinflammatory endothelial response to S100A8/A9 after preactivation through advanced glycation end products. Cardiovasc Diabetol. 2006 Mar 30; 5:6. PMID: 16573830.
      Citations:    
    89. Kettlewell S, Most P, Currie S, Koch WJ, Smith GL. S100A1 increases the gain of excitation-contraction coupling in isolated rabbit ventricular cardiomyocytes. J Mol Cell Cardiol. 2005 Dec; 39(6):900-10. PMID: 16236309.
      Citations:    
    90. Pleger ST, Remppis A, Heidt B, V?lkers M, Chuprun JK, Kuhn M, Zhou RH, Gao E, Szabo G, Weichenhan D, M?ller OJ, Eckhart AD, Katus HA, Koch WJ, Most P. S100A1 gene therapy preserves in vivo cardiac function after myocardial infarction. Mol Ther. 2005 Dec; 12(6):1120-9. PMID: 16168714.
      Citations:    
    91. Rottbauer W, Just S, Wessels G, Trano N, Most P, Katus HA, Fishman MC. VEGF-PLCgamma1 pathway controls cardiac contractility in the embryonic heart. Genes Dev. 2005 Jul 01; 19(13):1624-34. PMID: 15998812.
      Citations:    
    92. Most P, Boerries M, Eicher C, Schweda C, V?lkers M, Wedel T, S?llner S, Katus HA, Remppis A, Aebi U, Koch WJ, Schoenenberger CA. Distinct subcellular location of the Ca2+-binding protein S100A1 differentially modulates Ca2+-cycling in ventricular rat cardiomyocytes. J Cell Sci. 2005 Jan 15; 118(Pt 2):421-31. PMID: 15654019.
      Citations:    
    93. Liu HR, Gao E, Hu A, Tao L, Qu Y, Most P, Koch WJ, Christopher TA, Lopez BL, Alnemri ES, Zervos AS, Ma XL. Role of Omi/HtrA2 in apoptotic cell death after myocardial ischemia and reperfusion. Circulation. 2005 Jan 04; 111(1):90-6. PMID: 15611365.
      Citations:    
    94. Most P, Pleger ST, V?lkers M, Heidt B, Boerries M, Weichenhan D, L?ffler E, Janssen PM, Eckhart AD, Martini J, Williams ML, Katus HA, Remppis A, Koch WJ. Cardiac adenoviral S100A1 gene delivery rescues failing myocardium. J Clin Invest. 2004 Dec; 114(11):1550-63. PMID: 15578088.
      Citations:    
    95. Most P, Eicher C, V?lkers M, Pleger ST, Katus HA. Hope for a broken heart? Trends Biotechnol. 2004 Oct; 22(10):487-9. PMID: 15450736.
      Citations:    
    96. Remppis A, Pleger ST, Most P, Lindenkamp J, Ehlermann P, Schweda C, L?ffler E, Weichenhan D, Zimmermann W, Eschenhagen T, Koch WJ, Katus HA. S100A1 gene transfer: a strategy to strengthen engineered cardiac grafts. J Gene Med. 2004 Apr; 6(4):387-94. PMID: 15079813.
      Citations:    
    97. Most P, Boerries M, Eicher C, Schweda C, Ehlermann P, Pleger ST, Loeffler E, Koch WJ, Katus HA, Schoenenberger CA, Remppis A. Extracellular S100A1 protein inhibits apoptosis in ventricular cardiomyocytes via activation of the extracellular signal-regulated protein kinase 1/2 (ERK1/2). J Biol Chem. 2003 Nov 28; 278(48):48404-12. PMID: 12960148.
      Citations:    
    98. Most P, Koch WJ. Sealing the leak, healing the heart. Nat Med. 2003 Aug; 9(8):993-4. PMID: 12894157.
      Citations:    
    99. Most P, Remppis A, Pleger ST, L?ffler E, Ehlermann P, Bernotat J, Kleuss C, Heierhorst J, Ruiz P, Witt H, Karczewski P, Mao L, Rockman HA, Duncan SJ, Katus HA, Koch WJ. Transgenic overexpression of the Ca2+-binding protein S100A1 in the heart leads to increased in vivo myocardial contractile performance. J Biol Chem. 2003 Sep 05; 278(36):33809-17. PMID: 12777394.
      Citations:    
    100. Most P, Remppis A, Weber C, Bernotat J, Ehlermann P, Pleger ST, Kirsch W, Weber M, Uttenweiler D, Smith GL, Katus HA, Fink RH. The C terminus (amino acids 75-94) and the linker region (amino acids 42-54) of the Ca2+-binding protein S100A1 differentially enhance sarcoplasmic Ca2+ release in murine skinned skeletal muscle fibers. J Biol Chem. 2003 Jul 18; 278(29):26356-64. PMID: 12721284.
      Citations:    
    101. Most P, Remppis A, Katus HA. Conditional AC type VI expression in the heart: relevant insights into function of inducible target gene expression. Cardiovasc Res. 2002 Nov; 56(2):181-3. PMID: 12393087.
      Citations:    
    102. Remppis A, Most P, L?ffler E, Ehlermann P, Bernotat J, Pleger S, B?rries M, Reppel M, Fischer J, Koch WJ, Smith G, Katus HA. The small EF-hand Ca2+ binding protein S100A1 increases contractility and Ca2+ cycling in rat cardiac myocytes. Basic Res Cardiol. 2002; 97 Suppl 1:I56-62. PMID: 12479236.
      Citations:    
    103. Most P, Bernotat J, Ehlermann P, Pleger ST, Reppel M, B?rries M, Niroomand F, Pieske B, Janssen PM, Eschenhagen T, Karczewski P, Smith GL, Koch WJ, Katus HA, Remppis A. S100A1: a regulator of myocardial contractility. Proc Natl Acad Sci U S A. 2001 Nov 20; 98(24):13889-94. PMID: 11717446.
      Citations:    
    104. Ehlerman P, Remppis A, Most P, Bernotat J, Heizmann CW, Katus HA. Purification of the Ca2+-binding protein S100A1 from myocardium and recombinant Escherichia coli. J Chromatogr B Biomed Sci Appl. 2000 Jan 14; 737(1-2):39-45. PMID: 10681039.
      Citations:    
    105. Remppis A, Ehlermann P, Giannitsis E, Greten T, Most P, M?ller-Bardorff M, Katus HA. Cardiac troponin T levels at 96 hours reflect myocardial infarct size: a pathoanatomical study. Cardiology. 2000; 93(4):249-53. PMID: 11025351.
      Citations:    
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