Thomas Jefferson University

Andrea Eckhart

TitleVolunteer Faculty
InstitutionThomas Jefferson University
DepartmentFaculty Records and Publicatio - Thomas Jefferson University
Address1025 Walnut Street
Philadelphia PA 19107
Phone215-955-9992
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Miller MJ, Kennedy AD, Eckhart AD, Burrage LC, Wulff JE, Miller LAD, Milburn MV, Ryals JA, Beaudet AL, Sun Q, Sutton VR, Elsea SH. Erratum to: Untargeted metabolomic analysis for the clinical screening of inborn errors of metabolism. J Inherit Metab Dis. 2016 09; 39(5):757. PMID: 27225280.
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    2. Cobb J, Eckhart A, Motsinger-Reif A, Carr B, Groop L, Ferrannini E. a-Hydroxybutyric Acid Is a Selective Metabolite Biomarker of Impaired Glucose Tolerance. Diabetes Care. 2016 Jun; 39(6):988-95. PMID: 27208342.
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    3. Zhang X, Ai X, Nakayama H, Chen B, Harris DM, Tang M, Xie Y, Szeto C, Li Y, Li Y, Zhang H, Eckhart AD, Koch WJ, Molkentin JD, Chen X. Persistent increases in Ca(2+) influx through Cav1.2 shortens action potential and causes Ca(2+) overload-induced afterdepolarizations and arrhythmias. Basic Res Cardiol. 2016 Jan; 111(1):4. PMID: 26611208.
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    4. Miller MJ, Kennedy AD, Eckhart AD, Burrage LC, Wulff JE, Miller LA, Milburn MV, Ryals JA, Beaudet AL, Sun Q, Sutton VR, Elsea SH. Untargeted metabolomic analysis for the clinical screening of inborn errors of metabolism. J Inherit Metab Dis. 2015 Nov; 38(6):1029-39. PMID: 25875217.
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    5. Cobb J, Eckhart A, Perichon R, Wulff J, Mitchell M, Adam KP, Wolfert R, Button E, Lawton K, Elverson R, Carr B, Sinnott M, Ferrannini E. A novel test for IGT utilizing metabolite markers of glucose tolerance. J Diabetes Sci Technol. 2015 Jan; 9(1):69-76. PMID: 25261439.
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    6. Beebe K, Sampey B, Watkins SM, Milburn M, Eckhart AD. Understanding the apothecaries within: the necessity of a systematic approach for defining the chemical output of the human microbiome. Clin Transl Sci. 2014 Feb; 7(1):74-81. PMID: 24422665.
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    7. Deshpande DA, Yan H, Kong KC, Tiegs BC, Morgan SJ, Pera T, Panettieri RA, Eckhart AD, Penn RB. Exploiting functional domains of GRK2/3 to alter the competitive balance of pro- and anticontractile signaling in airway smooth muscle. FASEB J. 2014 Feb; 28(2):956-65. PMID: 24132623.
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    8. Eckhart AD, Beebe K, Milburn M. Metabolomics as a key integrator for "omic" advancement of personalized medicine and future therapies. Clin Transl Sci. 2012 Jun; 5(3):285-8. PMID: 22686208.
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    9. Brinks H, Rohde D, Voelkers M, Qiu G, Pleger ST, Herzog N, Rabinowitz J, Ruhparwar A, Silvestry S, Lerchenm?ller C, Mather PJ, Eckhart AD, Katus HA, Carrel T, Koch WJ, Most P. S100A1 genetically targeted therapy reverses dysfunction of human failing cardiomyocytes. J Am Coll Cardiol. 2011 Aug 23; 58(9):966-73. PMID: 21851887.
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    10. Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou RH, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G. Impaired neoangiogenesis in ?2-adrenoceptor gene-deficient mice: restoration by intravascular human ?2-adrenoceptor gene transfer and role of NF?B and CREB transcription factors. Br J Pharmacol. 2011 Feb; 162(3):712-21. PMID: 20958287.
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    11. Chen X, Nakayama H, Zhang X, Ai X, Harris DM, Tang M, Zhang H, Szeto C, Stockbower K, Berretta RM, Eckhart AD, Koch WJ, Molkentin JD, Houser SR. Calcium influx through Cav1.2 is a proximal signal for pathological cardiomyocyte hypertrophy. J Mol Cell Cardiol. 2011 Mar; 50(3):460-70. PMID: 21111744.
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    12. V?lkers M, Weidenhammer C, Herzog N, Qiu G, Spaich K, Wegner FV, Peppel K, M?ller OJ, Schinkel S, Rabinowitz JE, Hippe HJ, Brinks H, Katus HA, Koch WJ, Eckhart AD, Friedrich O, Most P. The inotropic peptide ?ARKct improves ?AR responsiveness in normal and failing cardiomyocytes through G(??)-mediated L-type calcium current disinhibition. Circ Res. 2011 Jan 07; 108(1):27-39. PMID: 21106943.
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    13. Brinks H, Boucher M, Gao E, Chuprun JK, Pesant S, Raake PW, Huang ZM, Wang X, Qiu G, Gumpert A, Harris DM, Eckhart AD, Most P, Koch WJ. Level of G protein-coupled receptor kinase-2 determines myocardial ischemia/reperfusion injury via pro- and anti-apoptotic mechanisms. Circ Res. 2010 Oct 29; 107(9):1140-9. PMID: 20814022.
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    14. Eckhart AD. Mineralocorticoid receptors, corticosteroids and the heart: where do we stand? J Hypertens. 2010 May; 28(5):889-91. PMID: 20395749.
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    15. Brinks HL, Eckhart AD. Regulation of GPCR signaling in hypertension. Biochim Biophys Acta. 2010 Dec; 1802(12):1268-75. PMID: 20060896.
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    16. Cohn HI, Xi Y, Pesant S, Harris DM, Hyslop T, Falkner B, Eckhart AD. G protein-coupled receptor kinase 2 expression and activity are associated with blood pressure in black Americans. Hypertension. 2009 Jul; 54(1):71-6. PMID: 19487588.
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    17. Zhou RH, Pesant S, Cohn HI, Soltys S, Koch WJ, Eckhart AD. Negative regulation of VEGF signaling in human coronary artery endothelial cells by G protein-coupled receptor kinase 5. Clin Transl Sci. 2009 Feb; 2(1):57-61. PMID: 20443868.
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    18. Ma YB, Li BY, Gao HQ, Yao M, Koch WJ, Eckhart AD, Zhou RH. [Activation of sterol regulatory element binding protein and its involvement in endothelial cell migration]. Zhonghua Bing Li Xue Za Zhi. 2009 Jan; 38(1):50-4. PMID: 19489226.
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    19. Harris DM, Chen X, Pesant S, Cohn HI, MacDonnell SM, Boucher M, Vinge LE, Raake P, Moraca SR, Li D, Most P, Houser SR, Koch WJ, Eckhart AD. Inhibition of angiotensin II Gq signaling augments beta-adrenergic receptor mediated effects in a renal artery stenosis model of high blood pressure. J Mol Cell Cardiol. 2009 Jan; 46(1):100-7. PMID: 18930063.
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    20. Cohn HI, Harris DM, Pesant S, Pfeiffer M, Zhou RH, Koch WJ, Dorn GW, Eckhart AD. Inhibition of vascular smooth muscle G protein-coupled receptor kinase 2 enhances alpha1D-adrenergic receptor constriction. Am J Physiol Heart Circ Physiol. 2008 Oct; 295(4):H1695-704. PMID: 18723764.
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    21. Martini JS, Raake P, Vinge LE, DeGeorge BR, DeGeorge B, Chuprun JK, Harris DM, Gao E, Eckhart AD, Pitcher JA, Koch WJ. Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes. Proc Natl Acad Sci U S A. 2008 Aug 26; 105(34):12457-62. PMID: 18711143.
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    22. Harris DM, Cohn HI, Pesant S, Eckhart AD. GPCR signalling in hypertension: role of GRKs. Clin Sci (Lond). 2008 Aug; 115(3):79-89. PMID: 18593382.
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    23. Raake PW, Vinge LE, Gao E, Boucher M, Rengo G, Chen X, DeGeorge BR, Matkovich S, Houser SR, Most P, Eckhart AD, Dorn GW, Koch WJ. G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure. Circ Res. 2008 Aug 15; 103(4):413-22. PMID: 18635825.
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    24. Boucher M, Pesant S, Lei YH, Nanton N, Most P, Eckhart AD, Koch WJ, Gao E. Simultaneous administration of insulin-like growth factor-1 and darbepoetin alfa protects the rat myocardium against myocardial infarction and enhances angiogenesis. Clin Transl Sci. 2008 May; 1(1):13-20. PMID: 20443814.
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    25. Ohtsu H, Higuchi S, Shirai H, Eguchi K, Suzuki H, Hinoki A, Brailoiu E, Eckhart AD, Frank GD, Eguchi S. Central role of Gq in the hypertrophic signal transduction of angiotensin II in vascular smooth muscle cells. Endocrinology. 2008 Jul; 149(7):3569-75. PMID: 18356277.
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    26. DeGeorge BR, Gao E, Boucher M, Vinge LE, Martini JS, Raake PW, Chuprun JK, Harris DM, Kim GW, Soltys S, Eckhart AD, Koch WJ. Targeted inhibition of cardiomyocyte Gi signaling enhances susceptibility to apoptotic cell death in response to ischemic stress. Circulation. 2008 Mar 18; 117(11):1378-87. PMID: 18316484.
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    27. Pleger ST, Harris DM, Shan C, Vinge LE, Chuprun JK, Berzins B, Pleger W, Druckman C, V?lkers M, Heierhorst J, ?ie E, Remppis A, Katus HA, Scalia R, Eckhart AD, Koch WJ, Most P. Endothelial S100A1 modulates vascular function via nitric oxide. Circ Res. 2008 Apr 11; 102(7):786-94. PMID: 18292599.
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    28. Mahadev K, Wu X, Donnelly S, Ouedraogo R, Eckhart AD, Goldstein BJ. Adiponectin inhibits vascular endothelial growth factor-induced migration of human coronary artery endothelial cells. Cardiovasc Res. 2008 May 01; 78(2):376-84. PMID: 18267956.
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    29. Zhou RH, Pesant S, Cohn HI, Eckhart AD. Enhanced sterol response element-binding protein in postintervention restenotic blood vessels plays an important role in vascular smooth muscle proliferation. Life Sci. 2008 Jan 16; 82(3-4):174-81. PMID: 18068195.
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    30. Harris DM, Cohn HI, Pesant S, Zhou RH, Eckhart AD. Vascular smooth muscle G(q) signaling is involved in high blood pressure in both induced renal and genetic vascular smooth muscle-derived models of hypertension. Am J Physiol Heart Circ Physiol. 2007 Nov; 293(5):H3072-9. PMID: 17873012.
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    31. MacDonnell SM, Kubo H, Harris DM, Chen X, Berretta R, Barbe MF, Kolwicz S, Reger PO, Eckhart A, Renna BF, Koch WJ, Houser SR, Libonati JR. Calcineurin inhibition normalizes beta-adrenergic responsiveness in the spontaneously hypertensive rat. Am J Physiol Heart Circ Physiol. 2007 Nov; 293(5):H3122-9. PMID: 17827263.
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    32. Giangrande PH, Zhang J, Tanner A, Eckhart AD, Rempel RE, Andrechek ER, Layzer JM, Keys JR, Hagen PO, Nevins JR, Koch WJ, Sullenger BA. Distinct roles of E2F proteins in vascular smooth muscle cell proliferation and intimal hyperplasia. Proc Natl Acad Sci U S A. 2007 Aug 07; 104(32):12988-93. PMID: 17652516.
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    33. Pleger ST, Most P, Boucher M, Soltys S, Chuprun JK, Pleger W, Gao E, Dasgupta A, Rengo G, Remppis A, Katus HA, Eckhart AD, Rabinowitz JE, Koch WJ. Stable myocardial-specific AAV6-S100A1 gene therapy results in chronic functional heart failure rescue. Circulation. 2007 May 15; 115(19):2506-15. PMID: 17470693.
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    34. Gao E, Boucher M, Chuprun JK, Zhou RH, Eckhart AD, Koch WJ. Darbepoetin alfa, a long-acting erythropoietin analog, offers novel and delayed cardioprotection for the ischemic heart. Am J Physiol Heart Circ Physiol. 2007 Jul; 293(1):H60-8. PMID: 17384131.
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    35. Lymperopoulos A, Rengo G, Funakoshi H, Eckhart AD, Koch WJ. Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure. Nat Med. 2007 Mar; 13(3):315-23. PMID: 17322894.
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    36. Most P, Seifert H, Gao E, Funakoshi H, V?lkers M, Heierhorst J, Remppis A, Pleger ST, DeGeorge BR, Eckhart AD, Feldman AM, Koch WJ. Cardiac S100A1 protein levels determine contractile performance and propensity toward heart failure after myocardial infarction. Circulation. 2006 Sep 19; 114(12):1258-68. PMID: 16952982.
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    37. Harris DM, Eckhart AD, Koch WJ. Galphaq and its Aktions. J Mol Cell Cardiol. 2006 May; 40(5):589-92. PMID: 16630627.
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    38. Kim J, Keys JR, Eckhart AD. Vascular smooth muscle migration and proliferation in response to lysophosphatidic acid (LPA) is mediated by LPA receptors coupling to Gq. Cell Signal. 2006 Oct; 18(10):1695-701. PMID: 16504475.
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    39. Pleger ST, Remppis A, Heidt B, V?lkers M, Chuprun JK, Kuhn M, Zhou RH, Gao E, Szabo G, Weichenhan D, M?ller OJ, Eckhart AD, Katus HA, Koch WJ, Most P. S100A1 gene therapy preserves in vivo cardiac function after myocardial infarction. Mol Ther. 2005 Dec; 12(6):1120-9. PMID: 16168714.
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    40. Tevaearai HT, Walton GB, Keys JR, Koch WJ, Eckhart AD. Acute ischemic cardiac dysfunction is attenuated via gene transfer of a peptide inhibitor of the beta-adrenergic receptor kinase (betaARK1). J Gene Med. 2005 Sep; 7(9):1172-7. PMID: 15880449.
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    41. Keys JR, Zhou RH, Harris DM, Druckman CA, Eckhart AD. Vascular smooth muscle overexpression of G protein-coupled receptor kinase 5 elevates blood pressure, which segregates with sex and is dependent on Gi-mediated signaling. Circulation. 2005 Aug 23; 112(8):1145-53. PMID: 16103237.
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    42. Mifune M, Ohtsu H, Suzuki H, Nakashima H, Brailoiu E, Dun NJ, Frank GD, Inagami T, Higashiyama S, Thomas WG, Eckhart AD, Dempsey PJ, Eguchi S. G protein coupling and second messenger generation are indispensable for metalloprotease-dependent, heparin-binding epidermal growth factor shedding through angiotensin II type-1 receptor. J Biol Chem. 2005 Jul 15; 280(28):26592-9. PMID: 15905175.
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    43. Most P, Pleger ST, V?lkers M, Heidt B, Boerries M, Weichenhan D, L?ffler E, Janssen PM, Eckhart AD, Martini J, Williams ML, Katus HA, Remppis A, Koch WJ. Cardiac adenoviral S100A1 gene delivery rescues failing myocardium. J Clin Invest. 2004 Dec; 114(11):1550-63. PMID: 15578088.
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    44. Tevaearai HT, Walton GB, Eckhart AD, Keys JR, Koch WJ. Heterotopic transplantation as a model to study functional recovery of unloaded failing hearts. J Thorac Cardiovasc Surg. 2002 Dec; 124(6):1149-56. PMID: 12447181.
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    45. Keys JR, Greene EA, Koch WJ, Eckhart AD. Gq-coupled receptor agonists mediate cardiac hypertrophy via the vasculature. Hypertension. 2002 Nov; 40(5):660-6. PMID: 12411459.
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    46. Tevaearai HT, Walton GB, Eckhart AD, Keys JR, Koch WJ. Donor heart contractile dysfunction following prolonged ex vivo preservation can be prevented by gene-mediated beta-adrenergic signaling modulation. Eur J Cardiothorac Surg. 2002 Nov; 22(5):733-7. PMID: 12414039.
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    47. Tevaearai HT, Eckhart AD, Walton GB, Keys JR, Wilson K, Koch WJ. Myocardial gene transfer and overexpression of beta2-adrenergic receptors potentiates the functional recovery of unloaded failing hearts. Circulation. 2002 Jul 02; 106(1):124-9. PMID: 12093781.
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    48. Kim J, Eckhart AD, Eguchi S, Koch WJ. Beta-adrenergic receptor-mediated DNA synthesis in cardiac fibroblasts is dependent on transactivation of the epidermal growth factor receptor and subsequent activation of extracellular signal-regulated kinases. J Biol Chem. 2002 Aug 30; 277(35):32116-23. PMID: 12048215.
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    49. Eckhart AD, Fentzke RC, Lepore J, Lang R, Lin H, Lefkowitz RJ, Koch WJ, Leiden JM. Inhibition of betaARK1 restores impaired biochemical beta-adrenergic receptor responsiveness but does not rescue CREB(A133) induced cardiomyopathy. J Mol Cell Cardiol. 2002 Jun; 34(6):669-77. PMID: 12054854.
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    50. Eckhart AD, Ozaki T, Tevaearai H, Rockman HA, Koch WJ. Vascular-targeted overexpression of G protein-coupled receptor kinase-2 in transgenic mice attenuates beta-adrenergic receptor signaling and increases resting blood pressure. Mol Pharmacol. 2002 Apr; 61(4):749-58. PMID: 11901213.
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    51. Eckhart AD, Koch WJ. Expression of a beta-adrenergic receptor kinase inhibitor reverses dysfunction in failing cardiomyocytes. Mol Ther. 2002 Jan; 5(1):74-9. PMID: 11786048.
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    52. Tevaearai HT, Eckhart AD, Koch WJ. Gene-mediated inhibition of the b-adrenergic receptor kinase: a new therapeutic strategy for heart failure. Minerva Cardioangiol. 2001 Dec; 49(6):389-94. PMID: 11733734.
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    53. Tevaearai HT, Eckhart AD, Shotwell KF, Wilson K, Koch WJ. Ventricular dysfunction after cardioplegic arrest is improved after myocardial gene transfer of a beta-adrenergic receptor kinase inhibitor. Circulation. 2001 Oct 23; 104(17):2069-74. PMID: 11673348.
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    54. Eckhart AD, Koch WJ. Transgenic studies of cardiac adrenergic receptor regulation. J Pharmacol Exp Ther. 2001 Oct; 299(1):1-5. PMID: 11561056.
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    55. Gaballa MA, Eckhart A, Koch WJ, Goldman S. Vascular beta-adrenergic receptor system is dysfunctional after myocardial infarction. Am J Physiol Heart Circ Physiol. 2001 Mar; 280(3):H1129-35. PMID: 11179056.
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    56. Gaballa MA, Eckhart AD, Koch WJ, Goldman S. Vascular beta-adrenergic receptor adenylyl cyclase system in maturation and aging. J Mol Cell Cardiol. 2000 Sep; 32(9):1745-55. PMID: 10966835.
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    57. Eckhart AD, Duncan SJ, Penn RB, Benovic JL, Lefkowitz RJ, Koch WJ. Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart. Circ Res. 2000 Jan 7-21; 86(1):43-50. PMID: 10625304.
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    58. Eckhart AD, Koch WJ. Beta-Adrenergic gene therapy for cardiovascular disease. Curr Control Trials Cardiovasc Med. 2000; 1(3):131-134. PMID: 11714426.
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    59. Akhter SA, Eckhart AD, Rockman HA, Shotwell K, Lefkowitz RJ, Koch WJ. In vivo inhibition of elevated myocardial beta-adrenergic receptor kinase activity in hybrid transgenic mice restores normal beta-adrenergic signaling and function. Circulation. 1999 Aug 10; 100(6):648-53. PMID: 10441103.
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    60. Anderson KM, Eckhart AD, Willette RN, Koch WJ. The myocardial beta-adrenergic system in spontaneously hypertensive heart failure (SHHF) rats. Hypertension. 1999 Jan; 33(1 Pt 2):402-7. PMID: 9931137.
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    61. Eckhart AD, Yang N, Xin X, Faber JE. Characterization of the alpha1B-adrenergic receptor gene promoter region and hypoxia regulatory elements in vascular smooth muscle. Proc Natl Acad Sci U S A. 1997 Aug 19; 94(17):9487-92. PMID: 9256509.
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    62. Yang N, Eckhart AD, Xin X, Faber JE. CRE-like response element regulates expression of rat alpha 2D-adrenergic receptor gene in vascular smooth muscle. Am J Physiol. 1997 Jul; 273(1 Pt 2):H85-95. PMID: 9249478.
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    63. Xin X, Yang N, Eckhart AD, Faber JE. Alpha1D-adrenergic receptors and mitogen-activated protein kinase mediate increased protein synthesis by arterial smooth muscle. Mol Pharmacol. 1997 May; 51(5):764-75. PMID: 9145914.
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    64. Bac?kov? L, Wilhelm J, Herget J, Novotn? J, Eckhart A. Oxidized collagen stimulates proliferation of vascular smooth muscle cells. Exp Mol Pathol. 1997; 64(3):185-94. PMID: 9439483.
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    65. Eckhart AD, Zhu Z, Arendshorst WJ, Faber JE. Oxygen modulates alpha 1B-adrenergic receptor gene expression by arterial but not venous vascular smooth muscle. Am J Physiol. 1996 Oct; 271(4 Pt 2):H1599-608. PMID: 8897957.
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    66. Chen L, Xin X, Eckhart AD, Yang N, Faber JE. Regulation of vascular smooth muscle growth by alpha 1-adrenoreceptor subtypes in vitro and in situ. J Biol Chem. 1995 Dec 29; 270(52):30980-8. PMID: 8537355.
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