Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade.
Galbiati F, Volonte D, Engelman JA, Watanabe G, Burk R, Pestell RG, Lisanti MP. Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade. EMBO J. 1998 Nov 16; 17(22):6633-48.
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3T3 Cells
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Animals
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Base Sequence
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Calcium-Calmodulin-Dependent Protein Kinases
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Caveolin 1
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Caveolin 2
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Caveolins
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Cell Transformation, Neoplastic
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Chromosomes, Human, Pair 7
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Culture Media, Serum-Free
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DNA, Antisense
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Down-Regulation
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Enzyme Activation
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Humans
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Membrane Proteins
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Mice
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Mice, Inbred BALB C
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Mice, Nude
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Microscopy, Electron, Scanning
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Neoplasms, Experimental
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Oligonucleotide Probes
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RNA, Messenger