"Adenylosuccinate Lyase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that, in the course of purine ribonucleotide biosynthesis, catalyzes the conversion of 5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole to 5'-phosphoribosyl-4-carboxamide-5-aminoimidazole and the conversion of adenylosuccinic acid to AMP. EC 4.3.2.2.
| Descriptor ID |
D000264
|
| MeSH Number(s) |
D08.811.520.232.300.200
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Adenylosuccinate Lyase".
Below are MeSH descriptors whose meaning is more specific than "Adenylosuccinate Lyase".
This graph shows the total number of publications written about "Adenylosuccinate Lyase" by people in this website by year, and whether "Adenylosuccinate Lyase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 1 | 0 | 1 |
| 2003 | 2 | 0 | 2 |
| 2004 | 2 | 0 | 2 |
| 2006 | 1 | 0 | 1 |
| 2007 | 3 | 0 | 3 |
| 2008 | 2 | 0 | 2 |
| 2009 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
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Below are the most recent publications written about "Adenylosuccinate Lyase" by people in Profiles.
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De Zoysa Ariyananda L, Antonopoulos C, Currier J, Colman RF. In vitro hybridization and separation of hybrids of human adenylosuccinate lyase from wild-type and disease-associated mutant enzymes. Biochemistry. 2011 Mar 1; 50(8):1336-46.
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Ariyananda Lde Z, Lee P, Antonopoulos C, Colman RF. Biochemical and biophysical analysis of five disease-associated human adenylosuccinate lyase mutants. Biochemistry. 2009 Jun 16; 48(23):5291-302.
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Sivendran S, Colman RF. Effect of a new non-cleavable substrate analog on wild-type and serine mutants in the signature sequence of adenylosuccinate lyase of Bacillus subtilis and Homo sapiens. Protein Sci. 2008 Jul; 17(7):1162-74.
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De Zoysa Ariyananda L, Colman RF. Evaluation of types of interactions in subunit association in Bacillus subtilis adenylosuccinate lyase. Biochemistry. 2008 Mar 4; 47(9):2923-34.
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Sivendran S, Segall ML, Rancy PC, Colman RF. Effect of Asp69 and Arg310 on the pK of His68, a key catalytic residue of adenylosuccinate lyase. Protein Sci. 2007 Aug; 16(8):1700-7.
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Tsai M, Koo J, Yip P, Colman RF, Segall ML, Howell PL. Substrate and product complexes of Escherichia coli adenylosuccinate lyase provide new insights into the enzymatic mechanism. J Mol Biol. 2007 Jul 13; 370(3):541-54.
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Segall ML, Cashman MA, Colman RF. Important roles of hydroxylic amino acid residues in the function of Bacillus subtilis adenylosuccinate lyase. Protein Sci. 2007 Mar; 16(3):441-8.
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Lee P, Colman RF. Expression, purification, and characterization of stable, recombinant human adenylosuccinate lyase. Protein Expr Purif. 2007 Feb; 51(2):227-34.
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Sivendran S, Patterson D, Spiegel E, McGown I, Cowley D, Colman RF. Two novel mutant human adenylosuccinate lyases (ASLs) associated with autism and characterization of the equivalent mutant Bacillus subtilis ASL. J Biol Chem. 2004 Dec 17; 279(51):53789-97.
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Segall ML, Colman RF. Gln212, Asn270, and Arg301 are critical for catalysis by adenylosuccinate lyase from Bacillus subtilis. Biochemistry. 2004 Jun 15; 43(23):7391-402.